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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29665672Regulatory Network of ARF in Cancer Development.Mol Cells2018 May 31Ko Adoi: 10.14348/molcells.2018.0100
14749371Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.Mol Cell Biol2004 FebScott LA-
26318587Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress.Oncotarget2015 Sep 29Dom??nguez Ddoi: 10.18632/oncotarget.4958.
22490850[Expression of multiple tumor suppressor gene p16 and its relationship with prognosis of gastric cancer patients].Zhonghua Zhong Liu Za Zhi2012 JanMa JM-
23804521Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients.Head Neck2014 AugPierini Sdoi: 10.1002/hed.23413
18807517[Correlation of p16/INK4a gene damages and protein expression in the tumor tissue of sporadic breast cancer].Arkh Patol2008 Jul-AugNemtsova MV-
15450420Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas.Mutat Res2004 Oct 4Garcia V-
26999279Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis.PLoS One2016 Mar 21Zhou Zdoi: 10.1371/journal.pone.0152050
17672936[Expression and significance of P16INK4A and PTEN in high-risk human papillomavirus-related cervical cancer].Ai Zheng2007 MayZhao XL-
18245468TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.Cancer Res2008 Feb 1Yarosh Wdoi: 10.1158/0008-5472.CAN-07-5012.
18413741Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification.Cancer Res2008 Apr 15Majid Sdoi: 10.1158/0008-5472.CAN-07-2290.
22960768Ink4-Arf locus in cancer and aging.Wiley Interdiscip Rev Dev Biol2012 Sep-OctSherr CJ-
22565003Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer.J Clin Oncol2012 Jun 10Gillison MLdoi: 10.1200/JCO.2011.38.4099
12632492Studies on microsatellite instability in p16 gene and expression of hMSH2 mRNA in human gastric cancer tissues.World J Gastroenterol2003 MarZhang QX-
25891176Effects of emodin on the demethylation of tumor-suppressor genes in pancreatic cancer PANC-1 cells.Oncol Rep2015 JunZhang Hdoi: 10.3892/or.2015.3914
15985168Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.BMC Gastroenterol2005 Jun 28Attri J-
15809712Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues.Int J Oncol2005 MayKim BN-
22049925Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.Cancer Sci2012 FebRabien Adoi: 10.1111/j.1349-7006.2011.02140.x
23645774P14ARF is down-regulated during tumour progression and predicts the clinical outcome in human breast cancer.Anticancer Res2013 MayWazir U-
20682398Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer.Cancer Genet Cytogenet2010 SepPehlivan Sdoi: 10.1016/j.cancergencyto.2010.05.019.
27429046Up-regulation of p16 by miR-877-3p inhibits proliferation of bladder cancer.Oncotarget2016 Aug 9Li Sdoi: 10.18632/oncotarget.10575.
28617556Correlation between methylation of the p16 promoter and cervical cancer incidence.Eur Rev Med Pharmacol Sci2017 MayWang FL-
29571246Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression.Biomed Pharmacother2018 FebWang Fdoi: 10.1016/j.biopha.2018.01.015
30136875CDKN2A Depletion Causes Aneuploidy and Enhances Cell Proliferation in Non-Immortalized Normal Human Cells.Cancer Invest2018H??lias-Rodzewicz Zdoi: 10.1080/07357907.2018.1491588
23894465p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells.PLoS One2013 Jul 24Chen YWdoi: 10.1371/journal.pone.0069389
17967182Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.Mol Cancer2007 Oct 29Tsou JA-
15197677[Investigations to the influence of tumor supressor gene p16 inactivation on the prognosis of head and neck squamous cell carcinoma].Laryngorhinootologie2004 JunKoscielny S-
17970082P16 methylation in serum as a potential marker for the malignancy of colorectal carcinoma.Anticancer Res2007 Sep-OctNakayama G-
12362979Expression of p16 in sporadic primary uveal melanoma.Acta Biochim Pol2002Lamperska K-
27323397GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF.Oncotarget2017 Mar 7Lee Sdoi: 10.18632/oncotarget.9957.
22751126p16(INK4A) represses the paracrine tumor-promoting effects of breast stromal fibroblasts.Oncogene2013 May 2Al-Ansari MMdoi: 10.1038/onc.2012.270
21820152Fluorescence in situ hybridization mapping of esophagectomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma.Hum Pathol2012 FebBrankley SMdoi: 10.1016/j.humpath.2011.04.018
19801173Genome integrity: linking pluripotency and tumorgenicity.Trends Genet2009 OctDeng Wdoi: 10.1016/j.tig.2009.09.004
18676825COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells.Cancer Res2008 Aug 1Mroz EAdoi: 10.1158/0008-5472.CAN-08-1279.
25611240The Loss of p16 Expression Worsens the Prognosis of OSCC.Appl Immunohistochem Mol Morphol2015 Nov-DecP??rez-Say??ns Mdoi: 10.1097/PAI.0000000000000133.
24525025ARF tumor suppression in the nucleolus.Biochim Biophys Acta2014 JunMaggi LB Jrdoi: 10.1016/j.bbadis.2014.01.016
12149228ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma.Blood2002 Aug 15Grnbaek K-
20307196p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells.Cancer Invest2010 JulZhang Jdoi: 10.3109/07357900903286941.
12359767Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.Cancer Res2002 Oct 1Uhrbom L-
27494112Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma.Acta Biochim Pol2016Strzelczyk JKdoi: 10.18388/abp.2015_1204
15796965Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16.Cancer Genet Cytogenet2005 Apr 15Kuroda H-
17923752Hypermethylation of p16INK4a in Korean non-small cell lung cancer patients.J Korean Med Sci2007 SepHong YS-
22534780Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers.J Natl Cancer Inst2012 Jun 20Mukherjee Bdoi: 10.1093/jnci/djs221
21488187Overexpressions of Cyclin B1, cdc2, p16 and p53 in human breast cancer: the clinicopathologic correlations and prognostic implications.Yonsei Med J2011 MayChae SWdoi: 10.3349/ymj.2011.52.3.445.
17881001Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.J Mol Biol2007 Nov 2Mahajan A-
22120712Abnormal MDMX degradation in tumor cells due to ARF deficiency.Oncogene2012 Aug 9Li Xdoi: 10.1038/onc.2011.534
18951899p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.Gastroenterology2009 JanWassermann Sdoi: 10.1053/j.gastro.2008.09.019
12532425Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A gene.Int J Cancer2003 Mar 10Sakano S-
25765380The Fidelity of p16 Staining as a Surrogate Marker of Human Papillomavirus Status in Fine-Needle Aspirates and Core Biopsies of Neck Node Metastases: Implications for HPV Testing Protocols.Acta Cytol2015Holmes BJdoi: 10.1159/000375148
26059208No benefit for regional control and survival by planned neck dissection in primary irradiated oropharyngeal cancer irrespective of p16 expression.Eur Arch Otorhinolaryngol2016 JulMaquieira Rdoi: 10.1007/s00405-015-3675-9
18760195p16 gene expression in basal cell carcinoma.Arch Med Res2008 OctEshkoor SAdoi: 10.1016/j.arcmed.2008.06.003.
27444279p16 upregulation is linked to poor prognosis in ERG negative prostate cancer.Tumour Biol2016 SepBurdelski C-
17658461Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.Biochem Biophys Res Commun2007 Sep 21Huang X-
12152785Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms.J Neuropathol Exp Neurol2002 AugPerry A-
15355988p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.J Biol Chem2004 Nov 26Woods YL-
22521293ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells.Life Sci2012 Oct 15von Brandenstein Mdoi: 10.1016/j.lfs.2012.04.014
18817867Bmi1 promotes prostate tumorigenesis via inhibiting p16(INK4A) and p14(ARF) expression.Biochim Biophys Acta2008 NovFan Cdoi: 10.1016/j.bbadis.2008.08.009
17201148Homozygous deletions of the INK4a/ARF locus in renal cell cancer.Anticancer Res2006 Nov-DecKasahara T-
26687648PTEN and p16 genes as epigenetic biomarkers in oral squamous cell carcinoma (OSCC): a study on south Indian population.Tumour Biol2016 JunSushma PSdoi: 10.1007/s13277-015-4648-8
16211008Distinct E2F-mediated transcriptional program regulates p14ARF gene expression.EMBO J2005 Nov 2Komori H-
20957490MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.Virchows Arch2010 DecNeves Filho EHdoi: 10.1007/s00428-010-0996-3
24104554Potentially functional variants of p14ARF are associated with HPV-positive oropharyngeal cancer patients and survival after definitive chemoradiotherapy.Carcinogenesis2014 JanSong Xdoi: 10.1093/carcin/bgt336
20405295Expression of p16 protein and epidermal growth factor receptor in patients with adenocarcinoma of the uterine cervix: an immunohistochemical analysis.Arch Gynecol Obstet2011 MarBodner Kdoi: 10.1007/s00404-010-1464-7
21108607Correlation of cell cycle regulatory proteins (p53 and p16(ink)(a)) and bcl-2 oncoprotein with mitotic index and thickness of primary cutaneous malignant melanoma.Bosn J Basic Med Sci2010 NovKostov M-
11908877Phenotypic changes associated with exogenous expression of p16INK4a in human glioma cells.Brain Tumor Pathol2001Noguchi A-
19212341Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.J Invest Dermatol2009 AugHaferkamp Sdoi: 10.1038/jid.2009.5
19258476CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.Cancer Epidemiol Biomarkers Prev2009 MarVasilatos SNdoi: 10.1158/1055-9965.EPI-08-0875
15485902ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway.Mol Cell Biol2004 NovBrady SN-
24440092Hypermethylation of the CDKN2A gene promoter is a frequent epigenetic change in periocular sebaceous carcinoma and is associated with younger patient age.Hum Pathol2014 MarLiau JYdoi: 10.1016/j.humpath.2013.10.019
21849808Inactivation of COX-2, HMLH1 and CDKN2A gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and Helicobacter pylori genotype.Pathobiology2011Alves MKdoi: 10.1159/000329475
26338965miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts.Oncotarget2015 Oct 6Al-Ansari MMdoi: 10.18632/oncotarget.4933.
25224768Expressions of p16 and p27 in urothelial carcinoma and their prognostic value.Kaohsiung J Med Sci2014 SepYang CHdoi: 10.1016/j.kjms.2014.05.003
12009890Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis.Biochemistry2002 May 21Zhang B-
18219279p14ARF hypermethylation is common but INK4a-ARF locus or p53 mutations are rare in Merkel cell carcinoma.J Invest Dermatol2008 JulLassacher Adoi: 10.1038/sj.jid.5701256
23887305The pathogenesis of atypical proliferative Brenner tumor: an immunohistochemical and molecular genetic analysis.Mod Pathol2014 FebKuhn Edoi: 10.1038/modpathol.2013.142
22883455[Expression and clinical values of HPV L1 and p16INK4a protein in uterine cervical lesions].Zhonghua Zhong Liu Za Zhi2012 MaySong Ydoi: 10
16699861Promoter methylation profile in gallbladder cancer.J Gastroenterol2006 MarRoa JC-
23449974Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress.J Biol Chem2013 Apr 26Kan CYdoi: 10.1074/jbc.M112.447821
12875969Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture.Am J Pathol2003 AugNatarajan E-
21797124P16 and retinoblastoma protein expression in endometrial carcinoma and clinical significance.Eur J Gynaecol Oncol2011Koh VM-
18199527p53-Dependent and p53-independent activation of autophagy by ARF.Cancer Res2008 Jan 15Abida WMdoi: 10.1158/0008-5472.CAN-07-2069.
17369842p16INK4A-silencing augments DNA damage-induced apoptosis in cervical cancer cells.Oncogene2007 Sep 6Lau WM-
15223748 cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas.Biotech Histochem2004 FebEvangelou K-
23803020Cyclin D1, retinoblastoma and p16 protein expression in carcinoma of the gallbladder.Asian Pac J Cancer Prev2013Srivastava V-
24577117Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial.Ann Oncol2014 AprVermorken JBdoi: 10.1093/annonc/mdt574
16760301Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.Ann Oncol2006 JunBazan V-
19514363[Role of the tumor suppressor ARF in oncogenesis].Arkh Patol2009 Jan-FebPimkina IuS-
24588771Inhibiting enhancer of zeste homolog 2 promotes cellular senescence in gastric cancer cells SGC-7901 by activation of p21 and p16.DNA Cell Biol2014 JunBai Jdoi: 10.1089/dna.2014.2340
26330556Post-translational Down-regulation of Melanoma Antigen-A11 (MAGE-A11) by Human p14-ARF Tumor Suppressor.J Biol Chem2015 Oct 9Minges JTdoi: 10.1074/jbc.M115.663641
15547691Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas.Int J Oncol2004 DecBachmann IM-
26191206A neurogenic tumor containing a low-grade malignant peripheral nerve sheath tumor (MPNST) component with loss of p16 expression and homozygous deletion of CDKN2A/p16: a case report showing progression from a neurofibroma to a high-grade MPNST.Int J Clin Exp Pathol2015 May 1Tajima S-
20568901Promoter methylation and expression changes of CDH1 and P16 genes in invasive breast cancer and adjacent normal breast tissue.Neoplasma2010Celebiler Cavusoglu A-
12060387Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma.J Invest Dermatol2002 JunChild FJ-
17850505Potent p53-independent tumor suppressor activity of ARF in melanoma-genesis.Pigment Cell Res2007 OctWidlund HR-
20683001Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer.Anticancer Res2010 JulGoto T-
22998186Emerging roles of mitochondrial p53 and ARF.Curr Drug Targets2012 DecItahana Y-
15582998p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity.J Biol Chem2005 Feb 25Normand G-
17659731Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.World J Gastroenterol2007 Jul 21Salek C-
18202755Expression of p16INK4a and MIB-1 in relation to histopathology and HPV types in cervical adenocarcinoma.Int J Oncol2008 FebMuller S-
19667129Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.J Cell Biol2009 Aug 10Yamakoshi Kdoi: 10.1083/jcb.200904105.
14585357Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes.Cancer Cell2003 OctDrayton S-
24503757p16 FISH deletion in surface epithelial mesothelial proliferations is predictive of underlying invasive mesothelioma.Am J Surg Pathol2014 MayHwang Hdoi: 10.1097/PAS.0000000000000176.
28068628Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53.Biomed Pharmacother2017 MarSubash-Babu Pdoi: 10.1016/j.biopha.2016.12.091
14519636p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors.Clin Cancer Res2003 Sep 15Perrone F-
26575287The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration.Elife2015 Nov 17Hesse RGdoi: 10.7554/eLife.07702.
11740049Inactivation of the p16 gene in human pituitary nonfunctioning tumors by hypermethylation is more common in null cell adenomas.Endocr Pathol2001 FallRuebel KH-
19131428Increased gamma-tubulin expression and P16INK4A promoter methylation occur together in preinvasive lesions and carcinomas of the breast.Ann Oncol2009 MarLiu Tdoi: 10.1093/annonc/mdn651
16447252TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.J Cell Physiol2006 JunAugello C-
23727582Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.Biochem Biophys Res Commun2013 Jun 28Poi MJdoi: 10.1016/j.bbrc.2013.05.078
20861610Immunohistochemical expression of retinoblastoma protein and p16 in renal cell carcinoma.Urol Int2011Maruschke Mdoi: 10.1159/000320510
18779733p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.Appl Immunohistochem Mol Morphol2009 JanHe Mdoi: 10.1097/PAI.0b013e3181719223.
20015385Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma.BMC Genomics2009 Dec 16Chang SJdoi: 10.1186/1471-2164-10-613.
21847682[Expression of the tumormarker p16INK4a in cytology specimens of the urinary bladder. A new means for early recognition and surveillance of urothelial cancer].Urologe A2011 SepTauber Sdoi: 10.1007/s00120-011-2693-5.
19140325[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas].Mol Biol (Mosk)2008 Nov-DecNemtsova MN-
11830494p14(ARF) nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways.Blood2002 Feb 15S??nchez-Aguilera A-
26283007Clinicopathological Significance and Potential Drug Target of CDKN2A/p16 in Endometrial Carcinoma.Sci Rep2015 Aug 18Su Ldoi: 10.1038/srep13238.
21942715Proteomic dissection of the von Hippel-Lindau (VHL) interactome.J Proteome Res2011 Nov 4Lai Ydoi: 10.1021/pr200642c
11861400Human tumor suppressor ARF impedes S-phase progression independent of p53.Cancer Res2002 Feb 15Yarbrough WG-
12924440Hypermethylation of the CDKN2/p16INK4A promotor in thyroid carcinogenesis.Pathol Res Pract2003Boltze C-
27333655Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa).Fukuoka Igaku Zasshi2016 JanTsujita J-
17936562Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.Cancer Cell2007 OctMallakin A-
24046371Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.Proc Natl Acad Sci U S A2013 Oct 1McLaughlin-Drubin MEdoi: 10.1073/pnas.1310432110
23308265Mimicking p14ARF phosphorylation influences its ability to restrain cell proliferation.PLoS One2013Vivo Mdoi: 10.1371/journal.pone.0053631
18703154Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer.Cell Biol Int2008 OctHe Ldoi: 10.1016/j.cellbi.2008.07.018
24937448Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16(INK4a) gene in human colorectal carcinoma (Caco-2) cells.Biochem Biophys Res Commun2014 Jul 18Naselli Fdoi: 10.1016/j.bbrc.2014.06.029
12582152Oligomerization of the human ARF tumor suppressor and its response to oxidative stress.J Biol Chem2003 May 23Men??ndez S-
20872974Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.World J Gastroenterol2010 Oct 7Zhang Y-
20501856ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA.Cancer Res2010 Jun 1Kawagishi Hdoi: 10.1158/0008-5472.CAN-10-0368
21880712Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.J Biol Chem2011 Oct 21Copp?? JPdoi: 10.1074/jbc.M111.257071
24983247Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.PLoS One2014 Jul 1Choy Edoi: 10.1371/journal.pone.0101283
19331161Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer.Anticancer Res2009 JanGoto T-
15897876CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.Oncogene2005 Aug 25Bernard D-
26043844Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas.J Ovarian Res2015 Jun 5Ferguson DCdoi: 10.1186/s13048-015-0163-1.
24161991CDK6 and p16INK4A in lymphoid malignancies.Oncotarget2013 NovKollmann K-
22667340Transforming growth factor beta 1 genotype and p16 as prognostic factors in head and neck squamous cell carcinoma.Acta Otolaryngol2012 SepLundberg Mdoi: 10.3109/00016489.2012.678944
25465729Influence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer.Radiother Oncol2014 DecKoerber SAdoi: 10.1016/j.radonc.2014.11.013
22925370Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing.J Transl Med2012 Aug 27Bihl MPdoi: 10.1186/1479-5876-10-173.
19618401Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids.Int J Cancer2010 Jan 15Zhu Wdoi: 10.1002/ijc.24728.
25138050Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis.Oncotarget2014 Aug 30Ortiz B-
21325273VentX trans-activates p53 and p16ink4a to regulate cellular senescence.J Biol Chem2011 Apr 8Wu Xdoi: 10.1074/jbc.M110.206078
21493295Loss of heterozygosity of tumor suppressor genes (p16, Rb, E-cadherin, p53) in hypopharynx squamous cell carcinoma.Otolaryngol Head Neck Surg2011 JulSang-Hyuk Lee SHdoi: 10.1177/0194599811401327.
25752701p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis.J Cell Physiol2016 FebVeneziano Ldoi: 10.1002/jcp.24976.
18394558Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.Cancer Cell2008 AprWiedemeyer Rdoi: 10.1016/j.ccr.2008.02.010.
26248224Effect of Iodine Intake on p14ARF and p16INK4a Expression in Thyroid Papillary Carcinoma in Rats.Med Sci Monit2015 Aug 6Sun Rdoi: 10.12659/MSM.893486.
24382891Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene.J Biol Chem2014 Feb 14Yoon JHdoi: 10.1074/jbc.M113.526855
12199782Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival.Br J Haematol2002 SepMateos MV-
12091906The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.Nat Med2002 JulLinggi B-
24136988The molecular balancing act of p16(INK4a) in cancer and aging.Mol Cancer Res2014 FebLaPak KMdoi: 10.1158/1541-7786.MCR-13-0350
12046062Tumor suppressor gene p16 and Rb expression in gastric cardia precancerous lesions from subjects at a high incidence area in northern China.World J Gastroenterol2002 JunZhou Y-
19450526Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.Mol Cell2009 May 15Witcher Mdoi: 10.1016/j.molcel.2009.04.001.
15014024Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China.Clin Cancer Res2004 Mar 1Ueki T-
25879218Molecular subtypes in stage II-III colon cancer defined by genomic instability: early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A.PLoS One2015 Apr 16Berg Mdoi: 10.1371/journal.pone.0122391
19130399Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor).Histol Histopathol2009 MarStalinska Ldoi: 10.14670/HH-24.299.
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Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr921974724Frame_Shift_DelnovelA30Gfs*180.58
BLCAchr921974685Missense_MutationNAP48L0.47
BLCAchr921971092Frame_Shift_InsnovelF90Lfs*300.68
BLCAchr921971209Splice_Siters730881677X51_splice0.73
BLCAchr921974737Missense_MutationnovelL31V0.41
BLCAchr921971112Missense_Mutationrs121913385H83Y0.45
BLCAchr921971200Missense_MutationnovelM53I0.35
BLCAchr921974698Frame_Shift_DelnovelN42Rfs*750.33
BLCAchr921971121Nonsense_Mutationrs121913388R80*0.71
BLCAchr921971004Missense_MutationNAE119K0.41
BLCAchr921971037Missense_MutationNAD108N0.38
BLCAchr921971121Nonsense_Mutationrs121913388R80*0.87
BLCAchr921974793Nonsense_Mutationrs141798398S12*0.37
BLCAchr921971112Missense_Mutationrs121913385H83Y0.5
BLCAchr921974793Missense_MutationnovelS12L0.18
BLCAchr921971019Missense_MutationNAP114T0.35
BLCAchr921971056Frame_Shift_InsnovelA102Rfs*190.39
BLCAchr921971093Frame_Shift_DelnovelG89Lfs*301
BLCAchr921974742Missense_MutationnovelR29P0.32
BLCAchr921974758Missense_Mutationrs761014328R24G0.56
BLCAchr921971049Frame_Shift_DelnovelA102Rfs*140.5
BLCAchr921971195Frame_Shift_DelnovelM54Tfs*910.17
BLCAchr921971037Missense_MutationNAD108N0.5
BLCAchr921971037Missense_Mutationrs121913381D108Y0.85
BLCAchr921971121Nonsense_Mutationrs121913388R80*0.58
BLCAchr921971210Splice_SiteNAX51_splice0.54
BLCAchr921974696Nonsense_Mutationrs730881673Y44*0.55
BLCAchr921971200Missense_MutationnovelM53I0.57
BLCAchr921971178Missense_MutationnovelE61K0.32
BLCAchr921971155Frame_Shift_InsnovelE69Tfs*800.5
CESCchr921968243Splice_SiteNAX153_splice0.75
CESCchr921974670Splice_RegionNA0.39
CESCchr921974736Missense_MutationNAL31R0.4
CESCchr921968235SilentnovelP155P0.48
CESCchr921970964Missense_MutationNAA132V0.44
CESCchr921974805Missense_MutationnovelS8I0.61
CESCchr921974806Missense_MutationnovelS8R0.61
CESCchr921971097Missense_MutationNAE88K0.88
CESCchr9219675643'Flanknovel0.3
CESCchr921970922Missense_MutationnovelD146G0.35
CHOLchr921971109Missense_Mutationrs11552822D84Y0.58
CHOLchr921971004Missense_MutationNAE119Q0.41
COADchr921970976Missense_MutationNAR128Q0.33
COADchr921974678Splice_RegionNAQ50Q0.35
COADchr9219681323'UTRnovel0.26
COADchr921974609IntronNA0.38
COADchr9219679323'UTRnovel0.21
COADchr9219675323'Flanknovel0.43
COADchr9219675743'Flanknovel0.06
COADchr921970903Splice_RegionNAS152S0.26
COADchr9219676533'Flanknovel0.13
COADchr9219681263'UTRnovel0.2
COADchr9219681483'UTRnovel0.31
COADchr921971059SilentNAA100A0.38
COADchr9219675523'Flanknovel0.38
COADchr9219681053'UTRnovel0.33
COADchr9219673653'Flanknovel0.11
COADchr9219748685'UTRnovel0.38
COADchr9219680253'UTRnovel0.63
COADchr9219673183'Flankrs7689596940.29
ESCAchr921974677Splice_SitenovelX50_splice0.74
ESCAchr921971024Missense_Mutationrs587782797R112H0.15
ESCAchr921971112Missense_Mutationrs121913385H83Y0.33
ESCAchr921971112Missense_Mutationrs121913385H83Y0.9
ESCAchr921970895Splice_SitenovelX153_splice0.72
ESCAchr921970900Splice_SiteNAX153_splice0.21
ESCAchr921971026Frame_Shift_DelnovelG111Afs*80.52
ESCAchr921974786Frame_Shift_DelnovelP11Lfs*290.9
ESCAchr921968243Splice_SiteNAX153_splice0.59
ESCAchr921974718Frame_Shift_InsnovelL37Rfs*70.38
ESCAchr921971176Frame_Shift_DelnovelE61Dfs*851
ESCAchr921970902Missense_Mutationrs45476696D153N0.35
ESCAchr921974725Missense_Mutationrs757066045G35R0.15
GBMchr921971030Nonsense_MutationNAW110*0.52
GBMchr921971027Missense_MutationNAG111D0.15
GBMchr921974705Silentrs754366579P41P0.21
GBMchr921971029Nonsense_Mutationrs121913389W110*0.19
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.38
HNSCchr921971112Missense_Mutationrs121913385H83Y0.79
HNSCchr921974764Frame_Shift_DelnovelR22Gfs*40.52
HNSCchr921971097Nonsense_Mutationrs121913384E88*0.58
HNSCchr921971208Frame_Shift_DelnovelV51Sfs*20.32
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.3
HNSCchr921968243Splice_SiteNAX153_splice0.15
HNSCchr921971151In_Frame_DelnovelL62_E69del0.33
HNSCchr921971030Nonsense_MutationNAW110*0.8
HNSCchr921971007Missense_MutationnovelA118T0.37
HNSCchr921971009Frame_Shift_DelNAL117Rfs*290.34
HNSCchr921968235Frame_Shift_DelnovelD156Ifs*370.59
HNSCchr921971107SilentNAD84D0.33
HNSCchr921971109Frame_Shift_InsnovelD84Lfs*50.33
HNSCchr921971037Missense_Mutationrs121913381D108Y0.44
HNSCchr921971029Nonsense_Mutationrs121913389W110*0.28
HNSCchr921971001Nonsense_MutationNAE120*0.31
HNSCchr921971029Nonsense_Mutationrs121913389W110*0.46
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.64
HNSCchr921970920Frame_Shift_DelnovelA147Pfs*460.76
HNSCchr921968244Splice_SiteNAX153_splice0.57
HNSCchr921971030Nonsense_MutationNAW110*0.16
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.75
HNSCchr921970972Nonsense_MutationNAY129*0.64
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.44
HNSCchr921971037Missense_Mutationrs121913381D108Y0.55
HNSCchr921971030Nonsense_MutationNAW110*0.69
HNSCchr921971097Missense_MutationNAE88K0.67
HNSCchr921974765In_Frame_DelnovelT18_A21del0.28
HNSCchr921971099Missense_MutationnovelR87P0.78
HNSCchr921971109Missense_MutationNAD84N0.67
HNSCchr921974704Missense_MutationNAN42H0.58
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.58
HNSCchr921971129Frame_Shift_DelnovelT77Ifs*690.35
HNSCchr921971130Missense_MutationnovelT77S0.36
HNSCchr921974694Frame_Shift_DelNAG45Vfs*80.43
HNSCchr921970901Splice_SiteNAX153_splice0.31
HNSCchr921971209Splice_SiteNAX51_splice0.53
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.72
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.41
HNSCchr921971097Frame_Shift_DelNAE88Rfs*580.63
HNSCchr921971154Nonsense_Mutationrs121913383E69*0.38
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.18
HNSCchr921971154Nonsense_Mutationrs121913383E69*0.33
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.43
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.59
HNSCchr921974756Frame_Shift_DelnovelR24*0.71
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.44
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.15
HNSCchr921971209Splice_SiteNAX51_splice0.25
HNSCchr921971210Splice_SiteNAX51_splice0.56
HNSCchr921971181Frame_Shift_DelNAA60Rfs*860.41
HNSCchr921971200Frame_Shift_InsnovelM53Ifs*20.3
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.35
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.44
HNSCchr921971122SilentNAT79T0.44
HNSCchr921974685Missense_MutationNAP48L0.28
HNSCchr921971001Nonsense_MutationNAE120*0.42
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.5
HNSCchr921974783Frame_Shift_DelnovelE10Afs*280.56
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.32
HNSCchr921974697Missense_MutationnovelY44C0.2
HNSCchr921971097Nonsense_Mutationrs121913384E88*0.33
HNSCchr921968243Splice_SiteNAX153_splice0.42
HNSCchr921971157Frame_Shift_DelnovelA68Rfs*780.33
HNSCchr921971029Nonsense_Mutationrs121913389W110*0.1
HNSCchr921971030Nonsense_MutationNAW110*0.88
HNSCchr921971139Missense_MutationNAD74N0.81
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.59
HNSCchr921968243Splice_SiteNAX153_splice0.48
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.66
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.13
HNSCchr921968243Splice_SiteNAX153_splice0.49
HNSCchr921971036Missense_MutationnovelD108V0.85
HNSCchr921974696Nonsense_MutationnovelY44*0.6
HNSCchr921974721Frame_Shift_Insrs398123152A36Gfs*80.4
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.26
HNSCchr921971111Missense_MutationNAH83R0.35
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.53
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.43
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.29
HNSCchr921968243Splice_SiteNAX153_splice0.25
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.57
HNSCchr921971029Nonsense_Mutationrs121913389W110*0.4
HNSCchr921974679Missense_MutationNAQ50R0.54
HNSCchr921971046In_Frame_DelnovelA100_L104del0.5
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.35
HNSCchr921971064Frame_Shift_DelnovelR99Gfs*470.53
HNSCchr921971187Nonsense_Mutationrs121913387R58*0.86
HNSCchr921971029Nonsense_Mutationrs121913389W110*0.36
HNSCchr921974800Nonsense_MutationnovelE10*0.72
HNSCchr921971108Missense_MutationNAD84G0.24
HNSCchr921971001Nonsense_MutationNAE120*0.44
HNSCchr921968234Frame_Shift_DelnovelD156Ifs*370.79
HNSCchr921968235SilentnovelP155P0.8
HNSCchr921970901Splice_SiteNAX153_splice0.75
HNSCchr921971097Nonsense_Mutationrs121913384E88*0.44
HNSCchr921971018Missense_Mutationrs121913386P114L0.15
HNSCchr921971089Missense_MutationnovelF90L0.47
HNSCchr921970901Splice_SiteNAX153_splice0.17
HNSCchr921970902Missense_Mutationrs45476696D153N0.17
HNSCchr921974766Frame_Shift_DelnovelW15Pfs*220.69
HNSCchr921971024Missense_Mutationrs587782797R112H0.32
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.43
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.19
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.64
HNSCchr921971121Nonsense_Mutationrs121913388R80*0.4
KIRPchr921971121Nonsense_Mutationrs121913388R80*0.81
LGGchr921971039Missense_Mutationrs370823171R107H0.42
LGGchr921974685Missense_Mutationrs763804037P48R0.21
LGGchr921971030Nonsense_MutationNAW110*0.1
LIHCchr921971191Missense_Mutationrs771138120S56R0.47
LIHCchr921974752Frame_Shift_DelnovelG23Rfs*270.41
LIHCchr921971102Missense_MutationnovelA86D0.31
LIHCchr921974777Frame_Shift_InsnovelT18Gfs*270.6
LIHCchr921971036Missense_MutationNAD108G0.34
LIHCchr921971037Missense_Mutationrs121913381D108Y0.4
LIHCchr9219681513'UTRnovel0.44
LIHCchr921971112Missense_MutationNAH83D0.59
LIHCchr921971210Splice_SiteNAX51_splice0.35
LIHCchr921971109Missense_Mutationrs11552822D84Y0.39
LIHCchr921974714Frame_Shift_DelnovelN39Tfs*140.21
LUADchr921971004In_Frame_DelnovelV115_A118del0.12
LUADchr921971210Splice_SiteNAX51_splice0.53
LUADchr921971037Frame_Shift_DelnovelL104Cfs*110.2
LUADchr921971040Frame_Shift_DelnovelG101Rfs*120.23
LUADchr921971146Missense_MutationNAN71K0.4
LUADchr921971108Missense_MutationNAD84V0.33