EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29953780	Defective expression of polarity protein Par3 promotes cervical tumorigenesis and metastasis.	Eur J Gynaecol Oncol	2017	Zheng JH	-
21549621	Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers.	Urol Oncol	2013 Jul	Namdarian B	doi: 10.1016/j.urolonc.2011.03.012
28526815	Partition-Defective 3 (PARD3) Regulates Proliferation, Apoptosis, Migration, and Invasion in Esophageal Squamous Cell Carcinoma Cells.	Med Sci Monit	2017 May 20	Wang L	-
23153534	Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.	Cancer Cell	2012 Nov 13	McCaffrey LM	doi: 10.1016/j.ccr.2012.10.003.
19737411	Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells.	BMC Cancer	2009 Sep 8	Kunnev D	doi: 10.1186/1471-2407-9-318.
26050620	Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition.	Oncogene	2016 Mar 10	Zhang K	doi: 10.1038/onc.2015.184
24856572	Cytoplasmic PAR-3 protein expression is associated with adverse prognostic factors in clear cell renal cell carcinoma and independently impacts survival.	Hum Pathol	2014 Aug	Dagher J	doi: 10.1016/j.humpath.2014.03.018
27855669	Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer.	BMC Cancer	2016 Nov 17	Nakamura H	-
28652146	Downregulation of PKC??/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.	Cell Signal	2017 Oct	Zhou Q	doi: 10.1016/j.cellsig.2017.06.016

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	34111255	Missense_Mutation	rs565005004	R1329W	0.93
BLCA	chr10	34696392	Missense_Mutation	NA	R50G	0.13
BLCA	chr10	34517033	Nonsense_Mutation	NA	Q117*	0.26
BLCA	chr10	34360214	Missense_Mutation	novel	E585K	0.15
BLCA	chr10	34337302	Nonsense_Mutation	novel	R848*	0.33
BLCA	chr10	34269742	Nonsense_Mutation	novel	Q1115*	0.32
BLCA	chr10	34378016	Missense_Mutation	novel	G497V	0.06
BLCA	chr10	34341748	Frame_Shift_Del	novel	*E762Afs9**	0.36
BLCA	chr10	34359255	Missense_Mutation	NA	K653N	0.35
BLCA	chr10	34331159	Missense_Mutation	novel	D934N	0.37
BLCA	chr10	34359194	Nonsense_Mutation	novel	G674*	0.47
BLCA	chr10	34399394	Nonsense_Mutation	novel	E276*	0.46
BLCA	chr10	34382764	Missense_Mutation	NA	R392K	0.11
BLCA	chr10	34269772	Missense_Mutation	novel	E1105K	0.34
BLCA	chr10	34312381	Intron	novel		0.03
BLCA	chr10	34131575	Nonsense_Mutation	NA	S1146*	0.13
BLCA	chr10	34382641	Missense_Mutation	novel	S433Y	0.44
BLCA	chr10	34131471	Missense_Mutation	NA	Q1181E	0.21
BLCA	chr10	34517033	Nonsense_Mutation	NA	Q117*	0.36
BLCA	chr10	34696392	Missense_Mutation	novel	R50C	0.5
BLCA	chr10	34382689	Missense_Mutation	rs115076370	S417C	0.18
BLCA	chr10	34269742	Nonsense_Mutation	novel	Q1115*	0.26
BLCA	chr10	34347978	Silent	novel	L735L	0.15
BLCA	chr10	34348058	Missense_Mutation	novel	D709N	0.13
BLCA	chr10	34470246	Nonsense_Mutation	novel	R141*	0.31
BRCA	chr10	34696374	Missense_Mutation	novel	G56R	0.04
BRCA	chr10	34111526	Missense_Mutation	NA	D1238E	0.13
BRCA	chr10	34111208	Silent	novel	R1344R	0.11
BRCA	chr10	34360226	Missense_Mutation	NA	D581N	0.31
BRCA	chr10	34111020	3'UTR	novel		0.49
BRCA	chr10	34331231	Missense_Mutation	rs566752362	R910C	0.18
BRCA	chr10	34111487	Silent	NA	Q1251Q	0.2
BRCA	chr10	34360104	Silent	NA	V621V	0.24
BRCA	chr10	34470170	Nonsense_Mutation	NA	S166*	0.24
BRCA	chr10	34331133	Missense_Mutation	NA	D942E	0.46
BRCA	chr10	34119648	Silent	novel	S1214S	0.33
BRCA	chr10	34450334	Silent	NA	L233L	0.19
CESC	chr10	34399398	Silent	NA	L274L	0.07
CESC	chr10	34111487	Missense_Mutation	novel	Q1251H	0.3
CESC	chr10	34337385	Missense_Mutation	rs753049516	R820Q	0.43
CESC	chr10	34331231	Missense_Mutation	rs566752362	R910C	0.24
CESC	chr10	34119677	Missense_Mutation	rs768549956	R1205W	0.26
CESC	chr10	34312290	Intron	novel		0.42
CESC	chr10	34317296	Missense_Mutation	novel	S962Y	0.38
CESC	chr10	34517033	Nonsense_Mutation	NA	Q117*	0.26
CESC	chr10	34360075	Missense_Mutation	rs779872179	S631C	0.66
CESC	chr10	34284145	Missense_Mutation	novel	E1059Q	0.4
CESC	chr10	34317324	Missense_Mutation	novel	E953K	0.34
CESC	chr10	34269832	Missense_Mutation	NA	D1085H	0.41
CHOL	chr10	34382690	Missense_Mutation	novel	S417A	0.15
COAD	chr10	34119656	Missense_Mutation	novel	E1212K	0.25
COAD	chr10	34131547	Silent	NA	Q1155Q	0.18
COAD	chr10	34111439	Silent	rs762535928	N1267N	0.35
COAD	chr10	34399382	Missense_Mutation	rs760519297	D280N	0.21
COAD	chr10	34331148	Silent	rs758182131	A937A	0.16
COAD	chr10	34337382	Missense_Mutation	novel	E821V	0.29
COAD	chr10	34111328	Silent	rs375380948	S1304S	0.29
COAD	chr10	34312290	Intron	novel		0.35
COAD	chr10	34382573	Frame_Shift_Del	NA	I456*	0.04
COAD	chr10	34378019	Missense_Mutation	rs12570964	R496Q	0.17
COAD	chr10	34348066	Missense_Mutation	rs768317108	A706V	0.36
COAD	chr10	34341737	Silent	novel	L769L	0.35
COAD	chr10	34269668	Silent	novel	S1139S	0.38
COAD	chr10	34384203	Silent	novel	H314H	0.46
COAD	chr10	34111237	Frame_Shift_Ins	rs750858319	*S1335Lfs15**	0.17
COAD	chr10	34382570	Missense_Mutation	novel	G457C	0.13
COAD	chr10	34696417	Splice_Region	novel	D41D	0.38
COAD	chr10	34312291	Intron	NA		0.58
COAD	chr10	34382550	Missense_Mutation	NA	Q463H	0.16
COAD	chr10	34360250	Missense_Mutation	novel	D573Y	0.42
COAD	chr10	34111411	Missense_Mutation	rs202148989	A1277T	0.12
COAD	chr10	34382802	Silent	novel	S379S	0.37
COAD	chr10	34317184	Missense_Mutation	NA	K999N	0.31
COAD	chr10	34384147	Missense_Mutation	rs752993561	R333Q	0.27
COAD	chr10	34382588	Missense_Mutation	NA	Y451H	0.09
DLBC	chr10	34359214	Missense_Mutation	rs142553947	S667C	0.24
DLBC	chr10	34337278	Missense_Mutation	novel	G856S	0.16
DLBC	chr10	34269859	Nonsense_Mutation	novel	R1076*	0.42
ESCA	chr10	34119697	Missense_Mutation	novel	S1198F	0.16
ESCA	chr10	34337295	Nonsense_Mutation	novel	S850*	0.38
ESCA	chr10	34696402	Frame_Shift_Ins	novel	*Q47Tfs16**	0.14
ESCA	chr10	34359233	Nonsense_Mutation	novel	E660_T661insLLFSVVSLCMST*	0.15
ESCA	chr10	34111220	Silent	rs533880946	A1340A	0.13
ESCA	chr10	34360260	Splice_Site	novel	X570_splice	0.15
ESCA	chr10	34378024	Silent	NA	L494L	0.31
ESCA	chr10	34269820	Missense_Mutation	novel	T1089S	0.12
GBM	chr10	34378034	Missense_Mutation	novel	K491R	0.08
GBM	chr10	34131495	Missense_Mutation	rs149035058	R1173C	0.22
GBM	chr10	34814986	Missense_Mutation	novel	T4P	0.56
GBM	chr10	34341659	Nonsense_Mutation	novel	W795*	0.24
GBM	chr10	34382563	Missense_Mutation	novel	R459T	0.04
HNSC	chr10	34382898	Silent	novel	A347A	0.24
HNSC	chr10	34401902	Missense_Mutation	novel	E244K	0.32
HNSC	chr10	34814964	Frame_Shift_Ins	novel	*R11Pfs52**	0.33
HNSC	chr10	34382636	Missense_Mutation	novel	P435A	0.08
HNSC	chr10	34111222	Missense_Mutation	rs756860827	A1340T	0.27
HNSC	chr10	34378037	Missense_Mutation	novel	V490E	0.25
HNSC	chr10	34269717	Missense_Mutation	rs774758431	M1123T	0.26
HNSC	chr10	34382885	Missense_Mutation	novel	I352V	0.58
HNSC	chr10	34331208	Missense_Mutation	novel	R917S	0.22
HNSC	chr10	34382548	Missense_Mutation	novel	L464R	0.24
HNSC	chr10	34360138	Nonsense_Mutation	NA	S610*	0.25
HNSC	chr10	34382871	Frame_Shift_Del	novel	*I353Mfs39**	0.34
KIRC	chr10	34336214	Missense_Mutation	novel	D867N	0.44
KIRC	chr10	34337412	Missense_Mutation	NA	D811A	0.23
KIRP	chr10	34359148	Missense_Mutation	NA	E689G	0.28
LGG	chr10	34269763	Missense_Mutation	rs754788137	M1108V	0.23
LGG	chr10	34377988	Missense_Mutation	novel	K506N	0.45
LGG	chr10	34399362	Silent	novel	I286I	0.08
LIHC	chr10	34401830	Missense_Mutation	NA	L268V	0.1
LIHC	chr10	34312291	Intron	novel		0.31
LIHC	chr10	34814997	5'UTR	novel		0.44
LIHC	chr10	34269658	Missense_Mutation	NA	S1143G	0.37
LIHC	chr10	34470230	Missense_Mutation	NA	P146L	0.27
LIHC	chr10	34382587	Missense_Mutation	rs780725925	Y451C	0.31
LIHC	chr10	34382886	Silent	NA	P351P	0.07
LIHC	chr10	34401845	Missense_Mutation	novel	I263V	0.05
LUAD	chr10	34269843	Missense_Mutation	novel	A1081V	0.21
LUAD	chr10	34382782	Missense_Mutation	novel	S386I	0.16
LUAD	chr10	34401870	Silent	novel	G254G	0.19
LUAD	chr10	34284173	Silent	novel	S1049S	0.49
LUAD	chr10	34517041	Missense_Mutation	novel	S114L	0.28
LUAD	chr10	34382687	Missense_Mutation	novel	H418Y	0.17
LUAD	chr10	34131472	Missense_Mutation	novel	E1180D	0.26
LUAD	chr10	34119717	Missense_Mutation	novel	Q1191H	0.25
LUAD	chr10	34111351	Missense_Mutation	novel	Q1297E	0.23
LUAD	chr10	34470123	Missense_Mutation	NA	Q182E	0.22
LUAD	chr10	34111468	Missense_Mutation	NA	R1258W	0.67
LUAD	chr10	34111516	Nonsense_Mutation	NA	Q1242*	0.27
LUAD	chr10	34111428	Missense_Mutation	NA	G1271V	0.21
LUAD	chr10	34399403	Nonsense_Mutation	NA	K273*	0.7
LUAD	chr10	34374995	Missense_Mutation	NA	G516V	0.26
LUAD	chr10	34374956	Missense_Mutation	NA	S529L	0.34
LUAD	chr10	34269867	Missense_Mutation	novel	R1073L	0.22
LUSC	chr10	34336233	Silent	NA	E860E	0.59
LUSC	chr10	34131554	Missense_Mutation	novel	R1153L	0.13
LUSC	chr10	34470082	Splice_Region	novel		0.49
LUSC	chr10	34317279	Frame_Shift_Del	novel	*D968Ifs11**	0.16
LUSC	chr10	34111524	Missense_Mutation	novel	S1239Y	0.11
LUSC	chr10	34378013	Frame_Shift_Ins	rs781028175	*A498Gfs9**	0.77
LUSC	chr10	34119684	Missense_Mutation	NA	Q1202H	0.5
LUSC	chr10	34312302	Intron	novel		0.28
LUSC	chr10	34284166	Missense_Mutation	NA	E1052K	0.09
LUSC	chr10	34312324	Intron	novel		0.1
LUSC	chr10	34284183	Missense_Mutation	NA	S1046F	0.1
LUSC	chr10	34111377	Missense_Mutation	novel	R1288P	0.17
LUSC	chr10	34470185	Missense_Mutation	NA	S161F	0.3
LUSC	chr10	34284192	Frame_Shift_Ins	novel	*I1043Nfs29**	0.15
LUSC	chr10	34284204	Frame_Shift_Del	novel	*G1039Vfs3**	0.38
LUSC	chr10	34336219	Missense_Mutation	novel	T865R	0.35
LUSC	chr10	34331253	Missense_Mutation	NA	L902F	0.17
LUSC	chr10	34470146	Nonsense_Mutation	NA	S174*	0.18
OV	chr10	34331294	Missense_Mutation	novel	S889T	0.04
OV	chr10	34359154	Missense_Mutation	novel	C687F	0.04
OV	chr10	34374960	Frame_Shift_Del	novel	*G521Ffs4**	0.1
OV	chr10	34331309	In_Frame_Del	NA	P880_G883del	0.36
OV	chr10	34382832	Silent	NA	L369L	0.15
OV	chr10	34269868	Missense_Mutation	novel	R1073G	0.11
PAAD	chr10	34111221	Missense_Mutation	rs144433754	A1340V	0.19
PAAD	chr10	34696362	Missense_Mutation	NA	D60N	0.15
PAAD	chr10	34374895	Silent	rs767494732	D549D	0.15
PCPG	chr10	34119703	Missense_Mutation	novel	S1196L	0.29
PRAD	chr10	34317295	Silent	novel	S962S	0.08
PRAD	chr10	34450338	Missense_Mutation	novel	K231N	0.11
PRAD	chr10	34382894	Missense_Mutation	rs201536019	R349C	0.45
READ	chr10	34337312	Silent	rs771996927	F844F	0.24
READ	chr10	34470093	Missense_Mutation	rs762091421	D192N	0.27
READ	chr10	34312284	Intron	novel		0.42
READ	chr10	34331231	Missense_Mutation	rs566752362	R910C	0.42
READ	chr10	34384190	Missense_Mutation	rs746189923	R319C	0.33
READ	chr10	34384141	Missense_Mutation	NA	R335K	0.29
SARC	chr10	34382667	Silent	rs749199780	S424S	0.07
SKCM	chr10	34470184	Silent	novel	S161S	0.38
SKCM	chr10	34317225	Missense_Mutation	NA	D986N	0.23
SKCM	chr10	34111325	Missense_Mutation	NA	E1305D	0.25
SKCM	chr10	34470264	Splice_Site	NA	X135_splice	0.27
SKCM	chr10	34331317	Missense_Mutation	novel	S881F	0.8
SKCM	chr10	34470157	Silent	NA	P170P	0.38
SKCM	chr10	34359267	Silent	NA	S649S	0.26
SKCM	chr10	34399362	Silent	novel	I286I	0.25
SKCM	chr10	34131528	Nonsense_Mutation	novel	Q1162*	0.31
SKCM	chr10	34337298	Missense_Mutation	novel	K849T	0.54
SKCM	chr10	34360166	Missense_Mutation	novel	L601F	0.34
SKCM	chr10	34111285	Missense_Mutation	rs573679528	P1319S	0.17
SKCM	chr10	34470185	Missense_Mutation	NA	S161F	0.49
SKCM	chr10	34470159	Missense_Mutation	NA	P170S	0.2
SKCM	chr10	34269883	Nonsense_Mutation	NA	R1068*	0.34
SKCM	chr10	34284183	Missense_Mutation	NA	S1046F	0.69
SKCM	chr10	34337312	Silent	rs771996927	F844F	0.12
SKCM	chr10	34111204	Missense_Mutation	NA	Q1346K	0.07
SKCM	chr10	34374879	Missense_Mutation	NA	E555K	0.35
SKCM	chr10	34378010	Missense_Mutation	NA	A499V	0.7
SKCM	chr10	34111403	Silent	NA	V1279V	0.36
SKCM	chr10	34269883	Nonsense_Mutation	NA	R1068*	0.32
SKCM	chr10	34348048	Missense_Mutation	rs771607063	R712Q	0.48
SKCM	chr10	34384190	Missense_Mutation	rs746189923	R319C	0.44
SKCM	chr10	34337312	Silent	rs771996927	F844F	0.46
SKCM	chr10	34111011	3'UTR	novel		0.64
SKCM	chr10	34317195	Missense_Mutation	NA	G996R	0.24
SKCM	chr10	34348022	Missense_Mutation	novel	G721R	0.26
SKCM	chr10	34360184	Missense_Mutation	NA	D595N	0.24
SKCM	chr10	34399366	Missense_Mutation	NA	G285E	0.3
SKCM	chr10	34317304	Silent	rs377290036	G959G	0.41
SKCM	chr10	34382666	Missense_Mutation	rs547955907	A425T	0.11
SKCM	chr10	34111274	Silent	novel	A1322A	0.35
SKCM	chr10	34119694	Missense_Mutation	novel	V1199A	0.24
SKCM	chr10	34131495	Missense_Mutation	rs149035058	R1173C	0.14
SKCM	chr10	34111183	Missense_Mutation	NA	P1353S	0.24
SKCM	chr10	34111239	Missense_Mutation	novel	P1334L	0.48
SKCM	chr10	34111240	Missense_Mutation	rs372887395	P1334S	0.48
SKCM	chr10	34284232	Nonsense_Mutation	rs201444228	R1030*	0.13
SKCM	chr10	34384182	Silent	NA	N321N	0.36
SKCM	chr10	34111533	Missense_Mutation	rs772939644	S1236F	0.39
SKCM	chr10	34374880	Silent	NA	R554R	0.31
SKCM	chr10	34360131	Silent	novel	E612E	0.23
STAD	chr10	34337380	Nonsense_Mutation	NA	G822*	0.35
STAD	chr10	34119657	Silent	NA	R1211R	0.33
STAD	chr10	34269685	Missense_Mutation	rs138980029	R1134W	0.08
STAD	chr10	34341645	Missense_Mutation	novel	I800N	0.15
STAD	chr10	34378107	Splice_Site	novel	X467_splice	0.35
STAD	chr10	34312291	Intron	NA		0.36
STAD	chr10	34470186	Frame_Shift_Del	novel	*S161Pfs62**	0.07
STAD	chr10	34337428	Splice_Site	novel	X806_splice	0.19
STAD	chr10	34284207	Missense_Mutation	rs374258573	T1038M	0.17
STAD	chr10	34111199	Frame_Shift_Del	novel	*Q1346Lfs114**	0.06
STAD	chr10	34312297	Intron	novel		0.39
STAD	chr10	34384147	Missense_Mutation	rs752993561	R333Q	0.39
STAD	chr10	34111427	Silent	rs760990072	G1271G	0.17
STAD	chr10	34374956	Missense_Mutation	NA	S529L	0.2
STAD	chr10	34341771	Missense_Mutation	novel	T758I	0.27
STAD	chr10	34360124	Missense_Mutation	rs774764458	A615T	0.17
STAD	chr10	34382573	Frame_Shift_Del	NA	I456*	0.31
STAD	chr10	34269776	Silent	NA	S1103S	0.34
STAD	chr10	34119634	Missense_Mutation	rs752058745	R1219H	0.13
STAD	chr10	34341737	Silent	novel	L769L	0.2
STAD	chr10	34111362	Missense_Mutation	rs754665239	R1293Q	0.08
STAD	chr10	34331273	Missense_Mutation	rs762819451	A896T	0.22
STAD	chr10	34312291	Intron	NA		0.26
STAD	chr10	34331151	Silent	rs763973634	P936P	0.34
STAD	chr10	34470083	Splice_Site	NA	X194_splice	0.09
STAD	chr10	34382656	Missense_Mutation	rs141769427	S428L	0.27
STAD	chr10	34399383	Silent	rs764181890	N279N	0.27
STAD	chr10	34331137	Missense_Mutation	NA	D941G	0.19
STAD	chr10	34450435	Missense_Mutation	rs192803216	Y199C	0.29
STAD	chr10	34337349	Missense_Mutation	rs562286256	R832H	0.25
STAD	chr10	34119714	Silent	rs745473559	S1192S	0.47
THCA	chr10	34696388	Missense_Mutation	NA	L51W	0.14
UCEC	chr10	34269684	Missense_Mutation	rs755202994	R1134Q	0.24
UCEC	chr10	34450329	Missense_Mutation	novel	E234D	0.06
UCEC	chr10	34269795	Missense_Mutation	rs147152702	M1097T	0.32
UCEC	chr10	34331265	Silent	rs116709084	A898A	0.2
UCEC	chr10	34119724	Missense_Mutation	novel	A1189V	0.13
UCEC	chr10	34284222	Missense_Mutation	novel	D1033G	0.09
UCEC	chr10	34312314	Intron	novel		0.26
UCEC	chr10	34317296	Missense_Mutation	novel	S962Y	0.28
UCEC	chr10	34374926	Missense_Mutation	novel	T539N	0.16
UCEC	chr10	34382554	Missense_Mutation	novel	I462S	0.37
UCEC	chr10	34517076	Silent	novel	E102E	0.27
UCEC	chr10	34284232	Nonsense_Mutation	rs201444228	R1030*	0.36
UCEC	chr10	34348048	Missense_Mutation	rs771607063	R712Q	0.31
UCEC	chr10	34450449	Splice_Site	NA	X195_splice	0.49
UCEC	chr10	34331304	Missense_Mutation	novel	K885N	0.4
UCEC	chr10	34347985	Missense_Mutation	novel	A733D	0.41
UCEC	chr10	34517113	Missense_Mutation	novel	G90D	0.42
UCEC	chr10	34359169	Missense_Mutation	novel	R682M	0.17
UCEC	chr10	34131495	Missense_Mutation	rs149035058	R1173C	0.38
UCEC	chr10	34470106	Silent	NA	S187S	0.43
UCEC	chr10	34131561	Missense_Mutation	novel	H1151N	0.42
UCEC	chr10	34341701	Silent	novel	S781S	0.4
UCEC	chr10	34360115	Missense_Mutation	novel	G618R	0.35
UCEC	chr10	34384154	Missense_Mutation	novel	D331N	0.35
UCEC	chr10	34269757	Missense_Mutation	novel	L1110I	0.25
UCEC	chr10	34401886	Missense_Mutation	rs766760918	R249H	0.48
UCEC	chr10	34337312	Silent	rs771996927	F844F	0.51
UCEC	chr10	34111179	Missense_Mutation	NA	F1354S	0.14
UCEC	chr10	34131518	Frame_Shift_Ins	novel	*K1165Rfs9**	0.03
UCEC	chr10	34331171	Missense_Mutation	rs748266747	D930N	0.18
UCEC	chr10	34111327	Missense_Mutation	rs764602683	E1305K	0.24
UCEC	chr10	34119707	Missense_Mutation	novel	H1195Y	0.43
UCEC	chr10	34348060	Missense_Mutation	NA	D708G	0.53
UCEC	chr10	34337371	Missense_Mutation	rs767949642	R825C	0.53
UCEC	chr10	34348049	Nonsense_Mutation	rs775291320	R712*	0.25
UCEC	chr10	34384155	Silent	rs151122883	G330G	0.38
UCEC	chr10	34516991	Missense_Mutation	novel	V131I	0.35
UCEC	chr10	34269854	Silent	novel	E1077E	0.33
UCEC	chr10	34337373	Missense_Mutation	novel	G824E	0.22
UCEC	chr10	34382893	Missense_Mutation	rs199923448	R349H	0.29
UCEC	chr10	34111238	Frame_Shift_Del	NA	*S1335Pfs8**	0.44
UCEC	chr10	34696397	Missense_Mutation	NA	V48A	0.28
UCEC	chr10	34312278	Intron	novel		0.44
UCEC	chr10	34360158	Silent	novel	V603V	0.3
UCEC	chr10	34131554	Missense_Mutation	rs776935606	R1153Q	0.24
UCEC	chr10	34111274	Silent	novel	A1322A	0.36
UCEC	chr10	34331265	Silent	rs116709084	A898A	0.25
UCEC	chr10	34317232	Silent	novel	E983E	0.49
UCEC	chr10	34341676	Missense_Mutation	novel	A790T	0.38
UCEC	chr10	34378019	Missense_Mutation	rs12570964	R496Q	0.41
UCEC	chr10	34382573	Frame_Shift_Del	NA	I456*	0.36
UCEC	chr10	34269780	Missense_Mutation	novel	S1102Y	0.57
UCEC	chr10	34131555	Missense_Mutation	rs762411737	R1153W	0.3
UCEC	chr10	34360099	Missense_Mutation	novel	S623F	0.42
UCEC	chr10	34131477	Missense_Mutation	novel	F1179L	0.28
UCEC	chr10	34384147	Missense_Mutation	rs752993561	R333Q	0.17
UCEC	chr10	34337408	Silent	novel	V812V	0.3
UCEC	chr10	34382720	Nonsense_Mutation	NA	R407*	0.4
UCEC	chr10	34382921	Missense_Mutation	NA	A340T	0.39
UCEC	chr10	34382573	Frame_Shift_Del	NA	I456*	0.28
UCEC	chr10	34374981	Nonsense_Mutation	novel	*V520_G521insHSETLRKNSF**	0.07
UCEC	chr10	34360260	Splice_Site	novel	X570_splice	0.23
UCEC	chr10	34384147	Missense_Mutation	rs752993561	R333Q	0.31
UCEC	chr10	34111439	Silent	rs762535928	N1267N	0.1
UCEC	chr10	34470246	Nonsense_Mutation	novel	R141*	0.33
UCEC	chr10	34336243	Frame_Shift_Ins	novel	*I857Tfs4**	0.12
UCEC	chr10	34336244	Splice_Site	novel	X857_splice	0.09
UCEC	chr10	34284226	Missense_Mutation	novel	D1032Y	0.33
UCEC	chr10	34312327	Intron	novel		0.38
UCEC	chr10	34337371	Missense_Mutation	rs767949642	R825C	0.42
UCEC	chr10	34516984	Missense_Mutation	rs372548458	R133P	0.27
UCEC	chr10	34111506	Missense_Mutation	rs371401357	S1245F	0.43
UCEC	chr10	34337371	Missense_Mutation	rs767949642	R825C	0.35
UCEC	chr10	34359245	Missense_Mutation	rs11540925	D657Y	0.44
UCEC	chr10	34382619	Missense_Mutation	novel	Q440H	0.07
UCEC	chr10	34382893	Missense_Mutation	rs199923448	R349H	0.25
UCEC	chr10	34401832	Missense_Mutation	NA	S267Y	0.24
UCEC	chr10	34111459	Missense_Mutation	NA	S1261G	0.32
UCEC	chr10	34131555	Missense_Mutation	rs762411737	R1153W	0.21
UCEC	chr10	34348065	Silent	rs746450270	A706A	0.1
UCEC	chr10	34382573	Frame_Shift_Del	NA	I456*	0.32
UCEC	chr10	34341632	Silent	rs781058544	A804A	0.45
UCEC	chr10	34131489	Missense_Mutation	rs780865181	R1175W	0.03
UCEC	chr10	34470153	Missense_Mutation	rs757021288	R172C	0.25
UCEC	chr10	34382834	Missense_Mutation	NA	L369V	0.39
UCEC	chr10	34269873	Missense_Mutation	novel	R1071M	0.35
UCEC	chr10	34111545	Missense_Mutation	novel	A1232V	0.38
UCEC	chr10	34359270	Missense_Mutation	NA	E648D	0.27
UCEC	chr10	34341746	Missense_Mutation	novel	L766F	0.1
UCEC	chr10	34269868	Nonsense_Mutation	novel	R1073*	0.49
UCEC	chr10	34284183	Missense_Mutation	NA	S1046F	0.36
UCEC	chr10	34341813	Missense_Mutation	novel	K744T	0.42
UCEC	chr10	34348045	Missense_Mutation	novel	R713K	0.16
UCEC	chr10	34378101	Missense_Mutation	novel	E469K	0.24
UCEC	chr10	34337289	Frame_Shift_Ins	novel	*S852Kfs8**	0.39
UCEC	chr10	34119741	Splice_Site	rs762847537	X1184_splice	0.47
UCEC	chr10	34341670	Missense_Mutation	novel	A792T	0.05
UCEC	chr10	34384250	Missense_Mutation	NA	L299M	0.31
UCEC	chr10	34317132	Silent	novel	L1017L	0.3
UCEC	chr10	34341768	Missense_Mutation	novel	V759A	0.5
UCEC	chr10	34348048	Missense_Mutation	rs771607063	R712Q	0.32
UCEC	chr10	34341632	Silent	rs781058544	A804A	0.41
UCS	chr10	34111528	Missense_Mutation	novel	D1238H	0.42
UVM	chr10	34359197	Nonsense_Mutation	novel	R673*	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
BLCA	DEL	0.1618	0.16614
ESCA	DEL	0.2283	9.2419e-07
HNSC	AMP	0.0766	5.7791e-06
HNSC	DEL	0.2471	5.4299e-15
LAML	DEL	0.0052	0.14746
READ	AMP	0.0545	1.9519e-21

Survival Analysis

Cancer	P-value	Q-value
STAD	0.028	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
ACC	0.00016	Kaplan-Meier Survival Analysis
LUSC	0.031	Kaplan-Meier Survival Analysis
PAAD	0.0059	Kaplan-Meier Survival Analysis
BLCA	0.0033	Kaplan-Meier Survival Analysis
LAML	0.0034	Kaplan-Meier Survival Analysis
UCEC	0.017	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.024	Kaplan-Meier Survival Analysis
UVM	0.0065	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000148498 (Gene tree)
Gene ID: 56288
Gene Symbol: PARD3
Alias: PAR3|PARD3A|Bazooka|Baz|ASIP|PPP1R118
Full Name: par-3 family cell polarity regulator
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 705,766 bases
Position: chr10:34,109,560-34,815,325
Accession: 16051
RBP type: non-canonical RBP
Summary: This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24425787	PIP induces the recycling of receptor tyrosine kinases.	Sci Signal	2014 Jan 14	Laketa V	doi: 10.1126/scisignal.2004532.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000374773	PARD3-205	3420	-	ENSP00000363905	1001 (aa)	-	Q5VWU8
ENST00000374776	PARD3-206	3389	-	ENSP00000363908	988 (aa)	-	Q8TEW0
ENST00000374788	PARD3-207	5996	-	ENSP00000363920	1353 (aa)	-	Q8TEW0
ENST00000374789	PARD3-208	6005	-	ENSP00000363921	1356 (aa)	-	Q8TEW0
ENST00000374768	PARD3-204	799	-	ENSP00000363900	179 (aa)	-	B1AP52
ENST00000466092	PARD3-211	806	-	-	- (aa)	-	-
ENST00000350537	PARD3-203	5867	-	ENSP00000311986	1310 (aa)	-	Q8TEW0
ENST00000545693	PARD3-214	5962	-	ENSP00000443147	1340 (aa)	-	Q8TEW0
ENST00000374790	PARD3-209	5825	-	ENSP00000363922	1296 (aa)	-	Q5VWV2
ENST00000544292	PARD3-212	2475	-	ENSP00000444429	747 (aa)	-	F5GZI3
ENST00000374794	PARD3-210	5669	-	ENSP00000363926	1244 (aa)	-	Q8TEW0
ENST00000545260	PARD3-213	5740	-	ENSP00000440857	1266 (aa)	-	Q8TEW0
ENST00000340077	PARD3-201	3518	-	ENSP00000341844	1031 (aa)	-	Q8TEW0
ENST00000346874	PARD3-202	5894	-	ENSP00000340591	1319 (aa)	-	Q8TEW0

Gene Model

Click here to download ENSG00000148498's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04080	Neuroactive ligand-receptor interaction	KEGG
hsa04144	Endocytosis	KEGG
hsa04360	Axon guidance	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04520	Adherens junction	KEGG
hsa04530	Tight junction	KEGG
hsa05165	Human papillomavirus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000148498	Hip	1.04812188133394E-5	17903296
ENSG00000148498	Hip	1.74693336596476E-5	17903296
ENSG00000148498	Intelligence Tests	1.7766400E-005	-
ENSG00000148498	Child Development Disorders, Pervasive	1.6277500E-005	-
ENSG00000148498	Precursor Cell Lymphoblastic Leukemia-Lymphoma	9E-6	19684603

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000148498	rs563507	10	34529060	A	Acute lymphoblastic leukemia (childhood)	19684603	[1.40-2.70]	2	EFO_0000220
ENSG00000148498	rs2197012	10	34294707	A	Educational attainment (MTAG)	30038396	[0.0069-0.0119] unit increase	0.0094	EFO_0004784
ENSG00000148498	rs1765174	10	34279104	C	Highest math class taken	30038396	[0.0097-0.0187] unit increase	0.0142	EFO_0004875
ENSG00000148498	rs641162	10	34277992	A	Self-reported math ability (MTAG)	30038396	[0.008-0.015] unit decrease	0.0115	EFO_0004875
ENSG00000148498	rs641162	10	34277992	A	Highest math class taken (MTAG)	30038396	[0.0094-0.016] unit decrease	0.0127	EFO_0004875
ENSG00000148498	rs142712198	10	34449119	?	General cognitive ability	29844566	z-score increase	4.533	EFO_0004337
ENSG00000148498	rs73267375	10	34600928	?	General cognitive ability	29844566	z-score decrease	4.47	EFO_0004337
ENSG00000148498	rs2007655	10	34297761	T	Educational attainment (years of education)	30038396	[0.0059-0.0113] unit increase	0.0086	EFO_0004784
ENSG00000148498	rs647758	10	34201926	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000148498	rs3004929	10	34125937	?	Body mass index	30595370			EFO_0004340
ENSG00000148498	rs1274475	10	34191654	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000148498	rs1274475	10	34191654	A	Lung function (FEV1/FVC)	30804560	[0.012-0.022] unit increase	0.0168	EFO_0004713
ENSG00000148498	rs138016380	10	34160538	C	Corneal astigmatism	30306274	[0.026-0.062] dioptres decrease	0.044	EFO_1002040
ENSG00000148498	rs11009904	10	34735416	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000148498's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0005515	protein binding	10934474.11257119.14676191.15161933.15254234.17057644.17979178.18838552.19893486.22579248.22653443.25241761.26496610.26766442.	IPI	Function
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	-	ISS	Function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	-	ISS	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005911	cell-cell junction	20332120.	IDA	Component
GO:0005911	cell-cell junction	-	ISS	Component
GO:0005912	adherens junction	21873635.	IBA	Component
GO:0005913	cell-cell adherens junction	21873635.	IBA	Component
GO:0005923	bicellular tight junction	14676191.22006950.	IDA	Component
GO:0005923	bicellular tight junction	-	ISS	Component
GO:0005938	cell cortex	21873635.	IBA	Component
GO:0006612	protein targeting to membrane	-	ISS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007155	cell adhesion	21873635.	IBA	Process
GO:0007163	establishment or maintenance of cell polarity	14676191.	TAS	Process
GO:0007179	transforming growth factor beta receptor signaling pathway	-	TAS	Process
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	11260256.	TAS	Process
GO:0007409	axonogenesis	14676191.	TAS	Process
GO:0008104	protein localization	21873635.	IBA	Process
GO:0008356	asymmetric cell division	10934474.	TAS	Process
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	-	ISS	Process
GO:0012505	endomembrane system	-	IEA	Component
GO:0016324	apical plasma membrane	21873635.	IBA	Component
GO:0019903	protein phosphatase binding	-	IEA	Function
GO:0022011	myelination in peripheral nervous system	-	ISS	Process
GO:0030010	establishment of cell polarity	21873635.	IBA	Process
GO:0030054	cell junction	-	IDA	Component
GO:0030054	cell junction	-	TAS	Component
GO:0031643	positive regulation of myelination	-	ISS	Process
GO:0032266	phosphatidylinositol-3-phosphate binding	-	ISS	Function
GO:0032991	protein-containing complex	-	IEA	Component
GO:0033269	internode region of axon	-	ISS	Component
GO:0035091	phosphatidylinositol binding	21873635.	IBA	Function
GO:0042802	identical protein binding	-	IEA	Function
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043296	apical junction complex	21873635.	IBA	Component
GO:0044295	axonal growth cone	-	IEA	Component
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	21873635.	IBA	Process
GO:0051660	establishment of centrosome localization	21873635.	IBA	Process
GO:0060341	regulation of cellular localization	-	IEA	Process
GO:0065003	protein-containing complex assembly	10934474.	TAS	Process
GO:0070830	bicellular tight junction assembly	-	ISS	Process
GO:0070830	bicellular tight junction assembly	-	TAS	Process
GO:0090162	establishment of epithelial cell polarity	-	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.