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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26940738miR-1271 inhibits migration, invasion and epithelial-mesenchymal transition by targeting ZEB1 and TWIST1 in pancreatic cancer cells.Biochem Biophys Res Commun2016 Apr 1Liu Hdoi: 10.1016/j.bbrc.2016.02.096
23844063MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer.PLoS One2013 Jul 2Majid Sdoi: 10.1371/journal.pone.0067686
26882471ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer.PLoS One2016 Feb 16Liu Ldoi: 10.1371/journal.pone.0148774
26511091KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer.Acta Biochim Biophys Sin (Shanghai)2015 DecLi Sdoi: 10.1093/abbs/gmv107
26498682MiR-652 inhibits acidic microenvironment-induced epithelial-mesenchymal transition of pancreatic cancer cells by targeting ZEB1.Oncotarget2015 Nov 24Deng Sdoi: 10.18632/oncotarget.5350.
25090005MicroRNA-150 predicts a favorable prognosis in patients with epithelial ovarian cancer, and inhibits cell invasion and metastasis by suppressing transcriptional repressor ZEB1.PLoS One2014 Aug 4Jin Mdoi: 10.1371/journal.pone.0103965
27878247Oridonin inhibition and miR200b3p/ZEB1 axis in human pancreatic cancer.Int J Oncol2017 JanGui Zdoi: 10.3892/ijo.2016.3772
28086235A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer.Oncotarget2017 Feb 14Preca BTdoi: 10.18632/oncotarget.14563.
27694892ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis.Oncogene2017 Apr 6Peng DHdoi: 10.1038/onc.2016.358
29126969SNHG16/miR-216-5p/ZEB1 signal pathway contributes to the tumorigenesis of cervical cancer cells.Arch Biochem Biophys2018 Jan 1Zhu Hdoi: 10.1016/j.abb.2017.11.003
28261684Evaluation of zinc finger E-box binding homeobox 1 and transforming growth factor-beta2 expression in bladder cancer tissue in comparison with healthy adjacent tissue.Investig Clin Urol2017 MarMahdavinezhad Adoi: 10.4111/icu.2017.58.2.140
29115509microRNA211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1.Mol Med Rep2018 JanChen Gdoi: 10.3892/mmr.2017.8006
29038174Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.EMBO J2017 Nov 15Cortes Mdoi: 10.15252/embj.201797345
26728244The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL.Sci Rep2016 Jan 5Ungewiss Cdoi: 10.1038/srep18652.
28849077MicroRNA643 regulates the expression of ZEB1 and inhibits tumorigenesis in osteosarcoma.Mol Med Rep2017 OctWang Hdoi: 10.3892/mmr.2017.7273
25880398An Rb1-dependent amplification loop between Ets1 and Zeb1 is evident in thymocyte differentiation and invasive lung adenocarcinoma.BMC Mol Biol2015 Mar 19Dean KCdoi: 10.1186/s12867-015-0038-4.
22080605β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.Proc Natl Acad Sci U S A2011 Nov 29Sanchez-Tillo Edoi: 10.1073/pnas.1108977108
20970163Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort?Hum Pathol2011 JanMontserrat Ndoi: 10.1016/j.humpath.2010.05.019
23381389Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma.Oncol Rep2013 AprCong Ndoi: 10.3892/or.2013.2267
26387539ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.Oncogene2015 Nov 12Sanchez-Tillo Edoi: 10.1038/onc.2015.352
18199550The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.Cancer Res2008 Jan 15Spaderna Sdoi: 10.1158/0008-5472.CAN-07-5682.
26547370Nuclear, cytoplasmic, and stromal expression of ZEB1 in squamous and small cell carcinoma of the esophagus.APMIS2015 DecGoscinski MAdoi: 10.1111/apm.12473.
22850877ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.J Clin Invest2012 SepAhn YHdoi: 10.1172/JCI63608
22262832Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.J Biol Chem2012 Mar 9Arima Ydoi: 10.1074/jbc.M111.313759
25521330ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres.Brain Pathol2015 NovKahlert UDdoi: 10.1111/bpa.12240
25142232Overexpression of zinc finger E-box binding homeobox factor 1 promotes tumor invasiveness and confers unfavorable prognosis in esophageal squamous cell carcinoma.Tumour Biol2014 DecYang Xdoi: 10.1007/s13277-014-2494-8
25868853Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b.Oncotarget2015Zhang P-
22847613Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.Oncogene2013 Jul 4Dong Pdoi: 10.1038/onc.2012.334
2601154253BP1 suppresses epithelial-mesenchymal transition by downregulating ZEB1 through microRNA-200b/429 in breast cancer.Cancer Sci2015 AugKong Xdoi: 10.1111/cas.12699
25275602TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion.Cell Death Dis2014 Oct 2Joseph JVdoi: 10.1038/cddis.2014.395.
27315529Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition.Int J Oncol2016 SepMuto Ydoi: 10.3892/ijo.2016.3583
27702662Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma.Cancer Lett2016 Dec 28Chang Ldoi: 10.1016/j.canlet.2016.09.034
27683118Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells.Oncotarget2016 Oct 25Li Sdoi: 10.18632/oncotarget.12217.
28714003MicroRNA130a inhibits growth and metastasis of osteosarcoma cells by directly targeting ZEB1.Mol Med Rep2017 SepYi Ldoi: 10.3892/mmr.2017.6968
28849018MicroRNA-199b targets the regulation of ZEB1 expression to inhibit cell proliferation, migration and invasion in nonsmall cell lung cancer.Mol Med Rep2017 OctWang Jdoi: 10.3892/mmr.2017.7195
29345288Downregulation of miR205 is associated with glioblastoma cell migration, invasion, and the epithelial-mesenchymal transition, by targeting ZEB1 via the Akt/mTOR signaling pathway.Int J Oncol2018 FebChen Wdoi: 10.3892/ijo.2017.4217
30168064Correlation between Expression of KLF5 and ZEB1 Transcription Factor Genes in Pancreatic Cancer.Dokl Biochem Biophys2018 JulZinovyeva MVdoi: 10.1134/S1607672918040129
29608014Expression of EMT inducers integrin-linked kinase (ILK) and ZEB1 in phyllodes breast tumors is associated with aggressive phenotype.Histol Histopathol2018 SepAkrida Idoi: 10.14670/HH-11-987
29903919Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion.EMBO J2018 Aug 1Rosmaninho Pdoi: 10.15252/embj.201797115
26191328MicroRNA-144 regulates proliferation, invasion, and apoptosis of cells in malignant solitary pulmonary nodule via zinc finger E-box-binding homeobox 1.Int J Clin Exp Pathol2015 May 1Zhang G-
26546081Down-regulation of FBP1 by ZEB1-mediated repression confers to growth and invasion in lung cancer cells.Mol Cell Biochem2016 JanZhang Jdoi: 10.1007/s11010-015-2595-8
25921099miR-128 modulates chemosensitivity and invasion of prostate cancer cells through targeting ZEB1.Jpn J Clin Oncol2015 MaySun Xdoi: 10.1093/jjco/hyv027
27965283ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1.Gut2017 Aprde Barrios Odoi: 10.1136/gutjnl-2015-310838
28337746Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells.J Pathol2017 JunSiddiqui Adoi: 10.1002/path.4897.
29325758MiR-186-5p upregulation inhibits proliferation, metastasis and epithelial-to-mesenchymal transition of colorectal cancer cell by targeting ZEB1.Arch Biochem Biophys2018 Feb 15Li Jdoi: 10.1016/j.abb.2018.01.002
28857253A TP73-AS1/miR-200a/ZEB1 regulating loop promotes breast cancer cell invasion and migration.J Cell Biochem2018 FebZou Qdoi: 10.1002/jcb.26380
21525039CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer.J Cell Sci2011 May 15Lorenzatti Gdoi: 10.1242/jcs.084194
20729552ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells.J Biol Chem2010 Oct 29Drake JMdoi: 10.1074/jbc.M110.136044
24577090Knockdown of BAG3 induces epithelial-mesenchymal transition in thyroid cancer cells through ZEB1 activation.Cell Death Dis2014 Feb 27Meng Xdoi: 10.1038/cddis.2014.32.
21791114ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor.Mol Cancer2011 Jul 27Lacher MDdoi: 10.1186/1476-4598-10-91.
23013135MiR-150 is associated with poor prognosis in esophageal squamous cell carcinoma via targeting the EMT inducer ZEB1.Cancer Sci2013 JanYokobori Tdoi: 10.1111/cas.12030
25455932The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer.Cancer Biol Ther2015Huang Qdoi: 10.4161/15384047.2014.987078.
16203744E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations.Hum Mol Genet2005 Nov 15Pena C-
24067373Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation.Cell Cycle2013 Jul 15Pieraccioli Mdoi: 10.4161/cc.25405.
18483486A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells.EMBO Rep2008 JunBurk Udoi: 10.1038/embor.2008.74
25315069δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.Cancer Med2015 JanFukagawa Adoi: 10.1002/cam4.347
26823172The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.FEBS Lett2016 JanHoshi Ydoi: 10.1002/1873-3468.12042
26783187miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.Int J Oncol2016 MarNishijima Ndoi: 10.3892/ijo.2016.3331
24257549Effect of down-regulated transcriptional repressor ZEB1 on the epithelial-mesenchymal transition of ovarian cancer cells.Int J Gynecol Cancer2013 OctChen Ddoi: 10.1097/IGC.0b013e3182a5e760.
19208835Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis.Cancer Res2009 Feb 15Inuzuka Tdoi: 10.1158/0008-5472.CAN-08-3620
22481253Lentivirus-delivered ZEB-1 small interfering RNA inhibits lung adenocarcinoma cell growth in vitro and in vivo.J Cancer Res Clin Oncol2012 AugLiu Ydoi: 10.1007/s00432-012-1206-2
25119590Molecular regulation of ovarian cancer cell invasion.Tumour Biol2014 NovSun Ndoi: 10.1007/s13277-014-2434-7
19935649The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.Nat Cell Biol2009 DecWellner Udoi: 10.1038/ncb1998
26717907SET8 induces epithelialmesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1.Mol Med Rep2016 FebHou Ldoi: 10.3892/mmr.2015.4733
22286765SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation.Oncogene2012 Nov 22Ono Hdoi: 10.1038/onc.2011.646
19225155ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells.Mol Biol Cell2009 AprDrake JMdoi: 10.1091/mbc.E08-10-1076
25155634Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition.Int J Cancer2015 Mar 15Koh Mdoi: 10.1002/ijc.29154
26540342An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer.Oncotarget2016 Jan 5Qin Ydoi: 10.18632/oncotarget.5968.
23667256Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development.J Biol Chem2013 Jun 28Vannier Cdoi: 10.1074/jbc.M113.467787
19116147Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer.FEBS Lett2009 Jan 22Adachi Ydoi: 10.1016/j.febslet.2008.12.042
26824417IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer.Oncotarget2016 Feb 9Bak Ydoi: 10.18632/oncotarget.7007.
25422078Pien Tze Huang inhibits metastasis of human colorectal carcinoma cells via modulation of TGF-β1/ZEB/miR-200 signaling network.Int J Oncol2015 FebShen Adoi: 10.3892/ijo.2014.2772
26334100The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5.Oncotarget2015 Sep 29Sundararajan Vdoi: 10.18632/oncotarget.4807.
25890268ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH.Mol Cancer2015 Apr 15Zheng Gdoi: 10.1186/s12943-015-0357-6.
17486063The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.Oncogene2007 Oct 25Aigner K-
26898939LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway.Cancer Lett2016 May 1Zhan HXdoi: 10.1016/j.canlet.2016.02.018
27133071The effects of Micro-429 on inhibition of cervical cancer cells through targeting ZEB1 and CRKL.Biomed Pharmacother2016 MayWang Ydoi: 10.1016/j.biopha.2016.03.035
24929761Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer.Surgery2014 JulBronsert Pdoi: 10.1016/j.surg.2014.02.018
26514226HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma.J Exp Clin Cancer Res2015 Oct 29Lv Xdoi: 10.1186/s13046-015-0245-3.
25270213[Aberrant expressions of β-catenin and ZEB1 in bladder cancer and their significance].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2014 OctNing Z-
26801503MicroRNA-455 suppresses non-small cell lung cancer through targeting ZEB1.Cell Biol Int2016 JunLi YJdoi: 10.1002/cbin.10584
20980099ZEB1-responsive genes in non-small cell lung cancer.Cancer Lett2011 Jan 1Gemmill RMdoi: 10.1016/j.canlet.2010.09.007
22205702Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.J Biol Chem2012 Feb 17Xiong Hdoi: 10.1074/jbc.M111.295964
24283570Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells.Breast Cancer Res2013 Nov 27Hugo HJdoi: 10.1186/bcr3580.
22213144Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer.J Surg Oncol2012 Jun 1Kurahara Hdoi: 10.1002/jso.23020
24968735Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2.Endocrine2015 MarGuan Hdoi: 10.1007/s12020-014-0326-7
20452118Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells.Cancer Lett2010 Oct 28Takeyama Ydoi: 10.1016/j.canlet.2010.04.008
28281973ABCB5-ZEB1 Axis Promotes Invasion and Metastasis in Breast Cancer Cells.Oncol Res2017 Mar 13Yao Jdoi: 10.3727/096504016X14734149559061.
24615544MiR-200c suppresses TGF-β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer.Int J Cancer2014 Sep 15Bai WDdoi: 10.1002/ijc.28782
26275944MiR-205 promotes motility of ovarian cancer cells via targeting ZEB1.Gene2015 Dec 15Niu Kdoi: 10.1016/j.gene.2015.08.017
25986864A Long Non-coding RNA Activated by Transforming Growth Factor-β is an Independent Prognostic Marker of Gastric Cancer.Ann Surg Oncol2015 DecSaito Tdoi: 10.1245/s10434-015-4554-8
25963537ZEB1 promotes epithelial-mesenchymal transition in cervical cancer metastasis.Fertil Steril2015 JunRan Jdoi: 10.1016/j.fertnstert.2015.03.016
26057751HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer.PLoS One2015 Jun 9Zhang Wdoi: 10.1371/journal.pone.0129603
19153669E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer.Cancer Metastasis Rev2009 JunSchmalhofer Odoi: 10.1007/s10555-008-9179-y.
24573236miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma.Oncol Rep2014 AprWang Ydoi: 10.3892/or.2014.3046
19921427Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells.Breast Cancer Res Treat2010 AugGraham TRdoi: 10.1007/s10549-009-0623-7
21224848The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.EMBO J2011 Feb 16Brabletz Sdoi: 10.1038/emboj.2010.349
19177200ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells.Neoplasia2009 FebClarhaut J-
26876920ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types.Nat Commun2016 Feb 15Lehmann Wdoi: 10.1038/ncomms10498.
21717425Zinc finger E-box binding factor 1 plays a central role in regulating Epstein-Barr virus (EBV) latent-lytic switch and acts as a therapeutic target in EBV-associated gastric cancer.Cancer2012 Feb 15Zhao Jdoi: 10.1002/cncr.26184
18321996Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.Am J Pathol2008 AprHuang Wdoi: 10.2353/ajpath.2008.070899
23827675Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity.Cell2013 Jul 3Chaffer CLdoi: 10.1016/j.cell.2013.06.005.
23791009The nuclear protein expression levels of SNAI1 and ZEB1 are involved in the progression and lymph node metastasis of cervical cancer via the epithelial-mesenchymal transition pathway.Hum Pathol2013 OctChen Zdoi: 10.1016/j.humpath.2013.04.001
24305877CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.Cancer Res2014 Jan 15Wang Ydoi: 10.1158/0008-5472.CAN-13-2182
18411277The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.J Biol Chem2008 May 30Korpal Mdoi: 10.1074/jbc.C800074200
24756066Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1.Cancer Biol Ther2014 JulQuan Ydoi: 10.4161/cbt.28877
27923654ZEB1 is neither sufficient nor required for epithelial-mesenchymal transition in LS174T colorectal cancer cells.Biochem Biophys Res Commun2017 Jan 22Jagle Sdoi: 10.1016/j.bbrc.2016.12.017
27717206Epigenetic silencing of miR-200c in breast cancer is associated with aggressiveness and is modulated by ZEB1.Genes Chromosomes Cancer2017 FebDamiano Vdoi: 10.1002/gcc.22422
27364559MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.Cancer Res2016 Sep 1Su Ldoi: 10.1158/0008-5472.CAN-16-0246
27079864MicroRNA-409-3p regulates cell invasion and metastasis by targeting ZEB1 in breast cancer.IUBMB Life2016 MayMa Zdoi: 10.1002/iub.1494
28383782The miR-200b-ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma.Mol Carcinog2017 SepTsai SCdoi: 10.1002/mc.22657
27500490ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.J Clin Invest2016 Sep 1Larsen JEdoi: 10.1172/JCI76725
28133913The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer.Mol Oncol2017 MarHanrahan Kdoi: 10.1002/1878-0261.12030
27150059Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer.Oncotarget2016 May 24Kan JYdoi: 10.18632/oncotarget.9140.
28266048The GRHL2/ZEB Feedback Loop-A Key Axis in the Regulation of EMT in Breast Cancer.J Cell Biochem2017 SepMooney SMdoi: 10.1002/jcb.25974
27036021miR-340 and ZEB1 negative feedback loop regulates TGF-β- mediated breast cancer progression.Oncotarget2016 May 3Hou LKdoi: 10.18632/oncotarget.8421.
28871949[Knock-down of ZEB1 inhibits the proliferation, invasion and migration of gastric cancer cells].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2017 AugChen D-
29288666ZEB1 stimulates breast cancer growth by up-regulating hTERT expression.Biochem Biophys Res Commun2018 Jan 22Yu Pdoi: 10.1016/j.bbrc.2017.12.139
28412735Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT.Oncotarget2017 Apr 18Kanska Jdoi: 10.18632/oncotarget.15429.
28583190ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1.J Exp Clin Cancer Res2017 Jun 5Song Wdoi: 10.1186/s13046-017-0545-x.
28416756Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis.Oncotarget2017 May 9Chen Hdoi: 10.18632/oncotarget.15634.
27533463IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells.Oncotarget2016 Sep 20Cao Hdoi: 10.18632/oncotarget.11282.
28830551Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer.Mol Cancer2017 Aug 23Su Wdoi: 10.1186/s12943-017-0711-y.
28618162ZEB1-regulated inflammatory phenotype in breast cancer cells.Mol Oncol2017 SepKatsura Adoi: 10.1002/1878-0261.12098
29039488MicroRNA-454 inhibits tumor cell proliferation, migration and invasion by downregulating zinc finger Eboxbinding homeobox 1 in gastric cancer.Mol Med Rep2017 DecSong Zdoi: 10.3892/mmr.2017.7758
29028100ZEB1 promotes prostate cancer proliferation and invasion through ERK1/2 signaling pathway.Eur Rev Med Pharmacol Sci2017 SepSong XF-
29719293PIK3R3 Promotes Metastasis of Pancreatic Cancer via ZEB1 Induced Epithelial-Mesenchymal Transition.Cell Physiol Biochem2018Peng YPdoi: 10.1159/000489382
29052277Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT.Cell Biol Int2018 MarZhao Ldoi: 10.1002/cbin.10894
27754741Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells.Small GTPases2018 Sep 3Handa Hdoi: 10.1080/21541248.2016.1249043
29187406PTBP3-Mediated Regulation of ZEB1 mRNA Stability Promotes Epithelial-Mesenchymal Transition in Breast Cancer.Cancer Res2018 Jan 15Hou Pdoi: 10.1158/0008-5472.CAN-17-0883
30015861LAMA4 expression is activated by zinc finger Eboxbinding homeobox1 and independently predicts poor overall survival in gastric cancer.Oncol Rep2018 SepWang Xdoi: 10.3892/or.2018.6564
29254997Pleiotropic Roles for ZEB1 in Cancer.Cancer Res2018 Jan 1Caramel Jdoi: 10.1158/0008-5472.CAN-17-2476
29295724Long Noncoding RNA CAT104 Promotes Cell Viability, Migration, and Invasion in Gastric Carcinoma Cells Through Activation of MicroRNA-381-Inhibiting Zinc Finger E-box-Binding Homeobox 1 (ZEB1) Expression.Oncol Res2018 Aug 23Yuan Gdoi: 10.3727/096504017X15144748428127
30257380Radiation exposure triggers the progression of triple negative breast cancer via stabilizing ZEB1.Biomed Pharmacother2018 NovLin Ydoi: 10.1016/j.biopha.2018.08.026
30487699Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.World J Gastroenterol2018 Nov 21Xu WYdoi: 10.3748/wjg.v24.i43.4893.
30455125MiR-873-5p inhibits cell migration, invasion and epithelial-mesenchymal transition in colorectal cancer via targeting ZEB1.Pathol Res Pract2019 JanLi Gdoi: 10.1016/j.prp.2018.10.008
29302045miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer.Cancer Gene Ther2018 MayZhou Xdoi: 10.1038/s41417-017-0005-y
29970904Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription.Oncogene2018 NovDeng SJdoi: 10.1038/s41388-018-0382-1
29084210ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.Oncogene2018 Feb 22Langer EMdoi: 10.1038/onc.2017.356
30448056LncRNA ZEB1-AS1/miR-409-3p/ZEB1 feedback loop is involved in the progression of non-small cell lung cancer.Biochem Biophys Res Commun2018 Dec 9Qu Rdoi: 10.1016/j.bbrc.2018.11.059
30917930MicroRNA-574-3p regulates epithelial mesenchymal transition and cisplatin resistance via targeting ZEB1 in human gastric carcinoma cells.Gene2019 Jun 5Wang Mdoi: 10.1016/j.gene.2019.03.043

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1031521310Missense_MutationnovelN659H0.31
ACCchr1031461186Missense_MutationnovelG70W0.38
BLCAchr1031520332Missense_MutationnovelE333Q0.33
BLCAchr1031461072Missense_MutationnovelD32N0.11
BLCAchr1031524070SilentNAF913F0.34
BLCAchr1031520863Missense_MutationnovelE510K0.06
BLCAchr1031520332Missense_MutationnovelE333Q0.16
BLCAchr1031520902Missense_MutationnovelE523Q0.13
BLCAchr1031521476Missense_MutationnovelR714K0.51
BLCAchr1031520228Missense_MutationnovelV298A0.13
BLCAchr1031510750Missense_MutationnovelE187Q0.22
BLCAchr1031520328Missense_MutationnovelK331N0.3
BLCAchr1031526770Missense_MutationnovelQ961E0.3
BLCAchr1031521170Missense_MutationnovelS612L0.36
BLCAchr1031321528Intronnovel0.08
BLCAchr10313192255'UTRnovel0.33
BLCAchr1031510771Missense_MutationnovelE194K0.16
BLCAchr1031527136Missense_MutationnovelE1083K0.22
BLCAchr1031502359Missense_MutationnovelE111K0.24
BRCAchr10315277323'UTRnovel0.29
BRCAchr1031527059Missense_MutationNAE1057G0.37
BRCAchr1031520669Missense_Mutationrs771873166N445S0.5
BRCAchr1031521840SilentNAT835T0.14
BRCAchr10313189555'Flanknovel0.34
BRCAchr1031526891Missense_MutationNAA1001V0.34
BRCAchr1031521862Missense_MutationnovelY843H0.4
BRCAchr1031526818Nonsense_MutationnovelQ977*0.08
BRCAchr1031510721Missense_MutationNAR177T0.37
BRCAchr1031526744Missense_MutationNAR952Q0.34
BRCAchr1031521356Missense_MutationNAT674K0.27
BRCAchr1031521410Missense_MutationnovelG692E0.06
BRCAchr1031527071Missense_MutationNAG1061E0.41
CESCchr1031521272Missense_MutationNAS646Y0.43
CESCchr1031510766Missense_Mutationrs753521729R192H0.14
CESCchr1031510856Frame_Shift_InsnovelH222Qfs*20.25zf-C2H2
CESCchr1031527046Missense_MutationnovelE1053Q0.42
CESCchr1031520904Frame_Shift_Insrs766305306V526Gfs*30.52
CESCchr10315276673'UTRnovel0.39
CESCchr1031527205Missense_MutationnovelG1106R0.13
COADchr1031520533Frame_Shift_DelNAG400Vfs*60.42
COADchr10313191725'UTRnovel0.53
COADchr1031520770Missense_MutationnovelL479I0.27
COADchr1031521652Missense_Mutationrs754135071A773T0.13
COADchr1031521514Missense_MutationNAQ727K0.36
COADchr1031521855Missense_MutationNAQ840H0.26
COADchr1031520328Missense_MutationnovelK331N0.31
COADchr1031527096Silentrs765424726E1069E0.25
COADchr1031321450Intronnovel0.41
COADchr1031521878Missense_Mutationrs759615272T848M0.3
COADchr10313191725'UTRnovel0.3
COADchr1031521469Missense_MutationnovelS712T0.34
COADchr1031526743Nonsense_MutationNAR952*0.42
COADchr1031521652Missense_MutationNAA773S0.52
COADchr1031321399Intronnovel0.25
COADchr1031527059Frame_Shift_DelNAK1058Nfs*200.36
COADchr1031520328Missense_MutationnovelK331N0.34
COADchr1031526774Missense_MutationnovelC962S0.35
COADchr1031520350Missense_MutationNAE339Q0.11
COADchr1031521636SilentnovelP767P0.21
COADchr1031321231Intronnovel0.31
COADchr1031502509Nonsense_MutationnovelG161*0.22
COADchr1031321350Intronnovel0.06
COADchr1031521326Missense_Mutationrs141110915S664Y0.12
COADchr1031520320Missense_Mutationrs754576407R329W0.24
COADchr1031521630Frame_Shift_InsnovelE766Rfs*570.06
COADchr1031521818Missense_MutationNAA828V0.11
DLBCchr1031526841SilentnovelS984S0.3
ESCAchr1031521360SilentnovelV675V0.5
ESCAchr1031521172Missense_MutationnovelK613Q0.5
ESCAchr1031373051Intronnovel0.17
ESCAchr1031521042SilentnovelP569P0.14
ESCAchr1031520205Missense_MutationnovelK290N0.08
ESCAchr1031520613Missense_MutationnovelR426S0.25
ESCAchr1031321474Intronnovel0.42
GBMchr1031524072Missense_MutationnovelQ914P0.1
GBMchr1031520905Missense_MutationnovelG524W0.15
GBMchr1031521742Missense_Mutationrs148358382A803T0.46
GBMchr1031521141SilentnovelL602L0.04
GBMchr1031524031Missense_MutationnovelE900D0.12
HNSCchr1031514625Missense_MutationnovelC236F0.11
HNSCchr1031521688Missense_MutationNAD785N0.27
HNSCchr1031527238Missense_MutationnovelS1117P0.31
HNSCchr1031521501SilentnovelT722T0.14
HNSCchr1031526955SilentnovelS1022S0.14
HNSCchr1031527099Silentrs577934227E1070E0.13
HNSCchr1031526671Splice_SitenovelX928_splice0.25
HNSCchr1031521606Missense_MutationnovelQ757H0.39
HNSCchr1031520334SilentnovelE333E0.25
HNSCchr1031527193Missense_MutationnovelA1102S0.36
HNSCchr1031524020SilentnovelR897R0.45
KIRCchr1031521688Missense_MutationNAD785N0.35
KIRPchr1031524021Missense_MutationNAR897L0.39
LGGchr1031502364Silentrs779622931C112C0.32
LGGchr1031521777Silentrs200125768I814I0.43
LIHCchr1031527192Missense_MutationnovelQ1101H0.25
LIHCchr10313191725'UTRnovel0.41
LIHCchr1031510759Nonsense_MutationnovelK190*0.36
LIHCchr1031520768Missense_MutationNAS478N0.55
LUADchr1031520369Missense_MutationnovelQ345L0.24
LUADchr1031524076SilentnovelK915K0.1
LUADchr1031521783SilentNAA816A0.46
LUADchr1031510800SilentNAS203S0.22
LUADchr1031461071SilentNAS31S0.34
LUADchr1031526780Missense_Mutationrs765964382K964R0.09
LUADchr1031523963Missense_MutationnovelV878L0.1
LUADchr1031521083Frame_Shift_DelnovelS583Ffs*70.3
LUADchr1031521899Missense_MutationNAE855A0.34
LUADchr1031520679SilentnovelP448P0.34
LUADchr1031526956Missense_MutationnovelD1023H0.47
LUADchr1031520878Missense_MutationNAK515Q0.23
LUADchr1031319271Missense_MutationnovelA13S0.75
LUADchr1031521863Missense_MutationNAY843C0.52
LUADchr1031524045Missense_Mutationrs78449005A905G0.38
LUADchr1031520384Missense_MutationnovelP350L0.29
LUADchr1031319290Missense_MutationNAN19S0.2
LUADchr1031521819SilentNAA828A0.27
LUADchr10313191425'UTRnovel0.25
LUADchr1031521163Missense_MutationnovelE610K0.1
LUADchr1031524003Missense_Mutationrs369330183P891L0.18
LUADchr1031521394Missense_MutationnovelP687T0.11
LUADchr1031520505Missense_MutationNAM390I0.07
LUADchr1031521923Missense_Mutationrs202145455P863R0.24
LUADchr1031520509Missense_MutationNAQ392K0.19
LUADchr1031521715Missense_MutationNAP794S0.23
LUADchr1031520170Missense_MutationNAH279Y0.34
LUADchr1031461132Missense_MutationnovelD52H0.15
LUADchr1031520722Missense_MutationnovelP463T0.61
LUADchr1031510691Nonsense_MutationNAS167*0.48
LUADchr1031526917Missense_MutationNAH1010N0.26
LUADchr1031510744Missense_MutationNAL185M0.12
LUADchr1031520135Missense_MutationNAP267Q0.25
LUADchr1031526826Missense_MutationnovelM979I0.28
LUADchr1031521769Missense_MutationnovelP812T0.45
LUADchr1031521715Missense_MutationnovelP794A0.09
LUADchr1031526876Missense_MutationnovelT996I0.1
LUADchr1031526758Nonsense_MutationnovelE957*0.11
LUADchr1031520390Missense_MutationnovelD352V0.25
LUADchr1031521694Missense_MutationNAE787Q0.1
LUADchr1031321411Intronnovel0.43
LUADchr1031527172Missense_MutationnovelD1095H0.23
LUADchr1031527070Missense_MutationNAG1061W0.67
LUADchr1031523955Nonsense_MutationNAS875*0.09
LUADchr1031521664Missense_MutationNAP777A0.17
LUADchr1031520813Missense_MutationnovelK493R0.16
LUADchr1031461158Silentrs142039874D60D0.31
LUADchr1031526779Nonsense_MutationNAK964*0.17
LUSCchr1031521154Missense_MutationnovelS607G0.42
LUSCchr1031319272Missense_MutationnovelA13E0.13
LUSCchr1031461164SilentnovelP62P0.14
LUSCchr1031521729SilentnovelN798N0.16
LUSCchr1031520387Missense_MutationnovelV351E0.42
LUSCchr1031521882SilentnovelV849V0.34
LUSCchr1031521538Missense_MutationNAL735F0.27
LUSCchr1031521484Missense_MutationNAQ717K0.27
LUSCchr1031502366Missense_MutationNAE113V0.14
LUSCchr1031520182Missense_MutationNAY283H0.11
LUSCchr1031510837Missense_MutationnovelE216K0.32zf-C2H2
LUSCchr1031461156Missense_MutationnovelD60Y0.48
LUSCchr1031520653Missense_MutationNAE440K0.52
LUSCchr1031520432Missense_Mutationrs754854286C366S0.5
LUSCchr1031521494Nonsense_MutationnovelL720*0.29
LUSCchr1031521135Nonsense_MutationnovelY600*0.34
LUSCchr1031461045Missense_MutationNAY23N0.8
LUSCchr1031520436SilentnovelS367S0.11
LUSCchr1031514653SilentNAC245C0.41
LUSCchr1031461094Missense_MutationnovelL39Q0.11
LUSCchr1031520895Missense_MutationNAK520N0.12
LUSCchr1031526707Missense_MutationnovelA940P0.3
LUSCchr1031520145SilentNAC270C0.25
LUSCchr1031520534Missense_MutationnovelG400V0.21
LUSCchr1031521087SilentnovelP584P0.11
LUSCchr1031526842Missense_MutationnovelY985N0.31
LUSCchr1031526954Nonsense_MutationNAS1022*0.26
LUSCchr1031520789Missense_MutationNAL485H0.19
LUSCchr1031520285Nonsense_MutationnovelS317*0.17
LUSCchr1031524044Missense_MutationNAA905P0.18
LUSCchr1031521650Missense_MutationnovelC772F0.63
LUSCchr1031520624Missense_MutationNAE430V0.38
LUSCchr1031521004Missense_MutationnovelQ557K0.35
LUSCchr1031521555SilentnovelP740P0.15
LUSCchr1031524048Missense_MutationnovelC906S0.23
LUSCchr1031521441SilentNAT702T0.63
LUSCchr1031527181Missense_MutationnovelA1098S0.13
LUSCchr1031502447Missense_MutationnovelP140L0.18
LUSCchr1031526688Missense_MutationnovelE933D0.35
OVchr1031521651Nonsense_MutationnovelC772*0.42
OVchr1031520832SilentNAA499A0.25
OVchr1031527096Silentrs765424726E1069E0.36
OVchr1031520258Missense_MutationNAT308I0.12
OVchr1031521372Frame_Shift_DelnovelP680Ffs*50.05
OVchr1031521651Silentrs143340752C772C0.16
PAADchr10315272983'UTRnovel0.25
PAADchr1031510697Missense_MutationnovelL169S0.19
PAADchr1031521369Missense_Mutationrs146821579Q678H0.2
PAADchr1031526838SilentnovelY983Y0.21
PAADchr1031521886Missense_MutationnovelP851S0.19
PCPGchr1031502430SilentnovelD134D0.13
PCPGchr1031524013Missense_MutationnovelK894N0.09
PRADchr1031521112Missense_MutationNAL593M0.09
PRADchr1031520550Missense_MutationNAI405M0.24
PRADchr1031526684Missense_MutationnovelH932R0.29
PRADchr1031521818Missense_MutationNAA828V0.47
PRADchr1031526743Nonsense_MutationNAR952*0.45
PRADchr1031520308Nonsense_MutationNAR325*0.1
READchr10315273093'UTRnovel0.23
READchr1031520830Missense_Mutationrs139511659A499T0.64
READchr1031524021Missense_Mutationrs35653460R897Q0.39
READchr1031461152Silentrs760520181E58E0.06
READchr1031321448Intronnovel0.44
READchr1031321417Intronnovel0.11
READchr1031321438Intronnovel0.12
SARCchr1031523933Missense_MutationnovelD868N0.17
SARCchr1031521647Missense_MutationnovelS771F0.41
SARCchr1031362868Intronnovel0.3
SARCchr1031527086In_Frame_InsnovelE1066_E1067insG0.07
SKCMchr1031520441Missense_MutationNAP369L0.11
SKCMchr1031495806Missense_MutationNAP96L0.59
SKCMchr1031520303Missense_MutationNAP323L0.4
SKCMchr1031521661Missense_MutationnovelE776K0.24
SKCMchr1031526770Nonsense_MutationNAQ961*0.44
SKCMchr1031520858Missense_MutationnovelL508S0.14
SKCMchr1031521639SilentNAL768L0.12
SKCMchr1031521918Silentrs267602470I861I0.25
SKCMchr1031521018SilentNAL561L0.32
SKCMchr1031520275Missense_MutationNAP314S0.54
SKCMchr1031461084Missense_MutationnovelE36K0.21
SKCMchr1031502416SilentnovelL130L0.21
SKCMchr1031520890Missense_MutationnovelD519N0.33
SKCMchr1031526869Missense_MutationnovelD994N0.31
SKCMchr1031527058Missense_MutationNAE1057K0.41
SKCMchr1031321407Intronnovel0.22
SKCMchr1031461209SilentNAG77G0.25
SKCMchr1031521566Missense_MutationNAG744E0.19
SKCMchr1031521915SilentNAV860V0.3
SKCMchr1031527043Missense_MutationNAE1052K0.21
SKCMchr1031461187Missense_Mutationrs758828036G70E0.21
SKCMchr1031526751Missense_MutationNAH954Q0.12
SKCMchr1031521620Missense_MutationnovelS762F0.35
SKCMchr1031521741Silentrs749059172I802I0.18
SKCMchr1031521673Missense_MutationNAD780H0.33
SKCMchr1031524070SilentNAF913F0.19
SKCMchr1031520309Missense_MutationNAR325Q0.33
SKCMchr1031521106Missense_MutationNAN591Y0.15
SKCMchr1031521248Missense_MutationNAS638L0.42
SKCMchr1031526755Missense_MutationNAG956R0.33
SKCMchr1031521884Missense_MutationNAS850N0.5
SKCMchr1031527184Missense_MutationnovelE1099K0.33
SKCMchr1031520632Nonsense_MutationnovelQ433*0.35
SKCMchr1031521373Missense_MutationNAP680S0.11
SKCMchr1031520347Nonsense_MutationNAQ338*0.35
SKCMchr1031520440Missense_MutationNAP369S0.32
SKCMchr1031521272Missense_MutationNAS646F0.48
SKCMchr1031521591SilentNAI752I0.41
SKCMchr1031520294Missense_MutationNAP320R0.41
SKCMchr1031520180Missense_MutationnovelS282F0.76
SKCMchr1031521010Missense_MutationNAP559S0.22
SKCMchr10315273093'UTRnovel0.7
SKCMchr1031461202Missense_MutationnovelR75K0.27
SKCMchr1031521741Silentrs749059172I802I0.27
SKCMchr1031526744Missense_MutationNAR952Q0.38
SKCMchr1031521505Missense_MutationNAE724K0.07
SKCMchr1031502446Missense_MutationNAP140S0.37
SKCMchr1031495823Missense_MutationNAE102K0.5
SKCMchr1031521566Missense_MutationNAG744E0.53
SKCMchr1031510771Missense_MutationNAE194Q0.32
SKCMchr1031514657Nonsense_MutationNAK247*0.25
SKCMchr10315272663'UTRnovel0.75
SKCMchr1031495829Missense_MutationnovelG104R0.51
SKCMchr1031521859Missense_Mutationrs776885703A842T0.51
SKCMchr1031521364Silentrs267602469L677L0.49
SKCMchr1031520328SilentNAK331K0.1
SKCMchr1031521274Missense_Mutationrs780092874P647S0.44
SKCMchr1031526910Silentrs747486342S1007S0.14
SKCMchr1031520679SilentnovelP448P0.36
SKCMchr1031520679SilentnovelP448P0.46
SKCMchr1031502500Missense_MutationnovelD158N0.47
SKCMchr1031521672SilentnovelK779K0.23
SKCMchr1031523936Missense_MutationNAE869K0.55
SKCMchr1031521392Missense_Mutationrs775271989S686F0.25
SKCMchr1031510865Missense_MutationNAG225E0.34
SKCMchr1031520907SilentnovelG524G0.34
SKCMchr1031526762Missense_MutationnovelK958M0.33
STADchr1031321470Intronrs3685932910.41
STADchr1031520838SilentNAN501N0.37
STADchr1031526994SilentNAD1035D0.36
STADchr1031520885Missense_MutationNAE517A0.14
STADchr1031526880SilentnovelE997E0.27
STADchr1031520833Missense_MutationNAT500A0.3
STADchr1031521583Missense_MutationnovelS750P0.33
STADchr1031520848Missense_MutationNAS505G0.06
STADchr1031321507Intronnovel0.22
STADchr1031321418Intronnovel0.19
STADchr1031520759Missense_MutationnovelI475N0.51
STADchr1031321436Intronrs7759949310.19
STADchr1031520130Silentrs746581968E265E0.29
STADchr1031523983Missense_MutationNAQ884H0.05
STADchr1031527039SilentnovelL1050L0.75
STADchr1031526743Nonsense_MutationNAR952*0.17
STADchr1031527094Missense_MutationNAE1069K0.43
STADchr1031520891Missense_MutationNAD519G0.32
STADchr1031510869Missense_MutationNAR226S0.26
STADchr1031521897Missense_MutationNAQ854H0.11
STADchr1031521713Missense_MutationNAI793N0.32
STADchr1031526959Missense_MutationNAE1024K0.5
STADchr1031521897Silentrs755654045Q854Q0.1
STADchr1031502393Missense_Mutationrs749371907H122R0.09
STADchr1031527133Missense_MutationNAN1082D0.2
STADchr1031319289Missense_MutationNAN19D0.25
UCECchr1031520144Missense_MutationNAC270Y0.3
UCECchr1031520282Missense_MutationNAL316R0.35
UCECchr1031521553Missense_MutationNAP740S0.31
UCECchr1031521917Missense_MutationnovelI861T0.17
UCECchr1031520757SilentNAI474I0.31
UCECchr1031521116Missense_MutationNAS594Y0.29
UCECchr1031524045Missense_MutationNAA905D0.41
UCECchr1031526998Nonsense_MutationNAE1037*0.34
UCECchr1031461209SilentNAG77G0.39
UCECchr10313188345'Flanknovel0.31
UCECchr1031520353Nonsense_MutationNAQ340*0.4
UCECchr1031521498Nonsense_MutationNAY721*0.35
UCECchr1031526954Missense_MutationNAS1022L0.47
UCECchr1031526959Missense_MutationNAE1024K0.41
UCECchr1031520807Missense_MutationnovelN491I0.32
UCECchr1031521431Missense_MutationNAR699I0.3
UCECchr1031521502Missense_MutationnovelA723T0.43
UCECchr1031526743Nonsense_MutationNAR952*0.35
UCECchr1031461193Missense_MutationnovelS72I0.22
UCECchr1031521329Missense_MutationnovelA665V0.36
UCECchr1031521447SilentnovelS704S0.29
UCECchr1031527069SilentnovelQ1060Q0.55
UCECchr1031520417Missense_MutationNAA361D0.17
UCECchr1031527205Nonsense_MutationnovelG1106*0.18
UCECchr1031521926Missense_MutationnovelN864S0.13
UCECchr1031461204Nonsense_MutationnovelE76*0.52
UCECchr1031521439Missense_MutationNAT702A0.37
UCECchr1031527155Missense_MutationnovelT1089N0.09
UCECchr1031521718Frame_Shift_InsnovelP795Lfs*80.08
UCECchr1031521719Missense_MutationnovelP795Q0.03
UCECchr1031520344Missense_MutationnovelL337I0.52
UCECchr1031521209Frame_Shift_InsnovelW628Vfs*30.39
UCECchr1031321436Intronrs7759949310.34
UCECchr1031521381Missense_MutationnovelK682N0.23
UCECchr1031521495Missense_MutationnovelL720F0.41
UCECchr1031514638Missense_MutationnovelF240L0.29
UCECchr10315276823'UTRnovel0.27
UCECchr10315277373'UTRnovel0.31
UCECchr1031520276Missense_Mutationrs764263722P314L0.38
UCECchr10315276093'UTRnovel0.34
UCECchr1031521028Nonsense_MutationnovelE565*0.44
UCECchr1031520932Missense_MutationnovelL533M0.5
UCECchr1031514614Silentrs149166539T232T0.35
UCECchr1031520568SilentnovelD411D0.55
UCECchr10315275673'UTRnovel0.4
UCECchr1031521210Frame_Shift_DelnovelK627Sfs*260.37
UCECchr1031510788Missense_MutationnovelN199K0.3
UCECchr1031526954Missense_MutationNAS1022L0.41
UCECchr1031520640Missense_MutationnovelN435K0.11
UCECchr1031520603Missense_MutationNAN423S0.38
UCECchr1031520430Missense_MutationNAN365K0.28
UCECchr1031526919Missense_MutationNAH1010Q0.14
UCECchr1031520905Frame_Shift_DelnovelV526*0.47
UCECchr1031526841SilentnovelS984S0.37
UCECchr1031321413Intronnovel0.36
UCECchr1031502456Missense_MutationnovelP143H0.27
UCECchr1031520248Nonsense_MutationnovelG305*0.18
UCECchr10315275493'UTRnovel0.2
UCECchr1031526965Missense_MutationnovelE1026K0.48
UCECchr1031387238Intronnovel0.15
UCECchr1031495829Nonsense_MutationNAG104*0.35
UCECchr1031527001Missense_MutationnovelK1038Q0.16
UCECchr1031510687Missense_MutationnovelF166V0.32
UCECchr1031521653Frame_Shift_InsNAE776Gfs*440.14
UCECchr1031321396Intronnovel0.38
UCECchr1031520581Missense_MutationnovelL416I0.45
UCECchr1031521760Missense_MutationnovelA809T0.24
UCECchr1031520308Nonsense_MutationNAR325*0.29
UCECchr1031520929Missense_MutationNAL532I0.2
UCECchr10315276443'UTRnovel0.09
UCECchr1031520277Silentrs373826858P314P0.14
UCECchr1031527231Silentrs753017859E1114E0.34
UCECchr1031520327Missense_MutationnovelK331R0.15
UCECchr1031521040Missense_MutationnovelP569A0.13
UCECchr1031521280Missense_MutationnovelP649S0.15
UCECchr1031521867SilentnovelT844T0.39
UCECchr10315276893'UTRnovel0.16
UCECchr10315272933'UTRnovel0.08
UCECchr10315272943'UTRnovel0.08
UCECchr1031520625Missense_MutationNAE430D0.29
UCECchr1031521669Missense_MutationnovelQ778H0.25
UCECchr10315279483'UTRnovel0.67
UCECchr1031321428Intronnovel0.27
UCECchr1031523960Nonsense_MutationnovelG877*0.19
UCECchr1031526933Missense_Mutationrs767228225A1015V0.37
UCECchr1031461162Missense_MutationnovelP62S0.29
UCECchr1031510797SilentnovelC202C0.47
UCECchr1031520841Missense_MutationnovelS502R0.36
UCECchr1031526743Nonsense_MutationNAR952*0.27
UCECchr10315276293'UTRnovel0.49
UCECchr10315276753'UTRnovel0.39
UCECchr1031524004Silentrs751487849P891P0.31
UCECchr1031526777Missense_MutationNAD963G0.27
UCECchr1031510785SilentnovelD198D0.27
UCECchr1031520845Missense_MutationnovelK504Q0.46
UCECchr1031520960Missense_MutationnovelN542S0.39
UCECchr1031521713Missense_MutationnovelI793T0.33
UCECchr10315275013'UTRnovel0.19
UCECchr1031521718Frame_Shift_InsnovelP795Lfs*90.12
UCECchr10315276943'UTRnovel0.4
UCSchr1031526806Missense_MutationnovelG973R1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
BLCADEL0.14460.16614
STADDEL0.0930.13903

Survival Analysis
CancerP-value Q-value
THYM0.0068

Kaplan-Meier Survival Analysis

KIRC0.00011

Kaplan-Meier Survival Analysis

STAD0.0053

Kaplan-Meier Survival Analysis

MESO0.036

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

KIRP0.0026

Kaplan-Meier Survival Analysis

BLCA0.011

Kaplan-Meier Survival Analysis

GBM0.023

Kaplan-Meier Survival Analysis

LIHC0.015

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

THCA0.019

Kaplan-Meier Survival Analysis

UVM0.0014

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000148516 (Gene tree)
Gene ID
6935
Gene Symbol
ZEB1
Alias
BZP|ZEB|AREB6|NIL-2-A|Zfhep|Zfhx1a|FECD6|TCF8|PPCD3
Full Name
zinc finger E-box binding homeobox 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
211,320 bases
Position
chr10:31,318,495-31,529,814
Accession
11642
RBP type
canonical RBP
Summary
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000444891zf-C2H2PF00096.262e-2416
ENSP00000444891zf-C2H2PF00096.262e-2426
ENSP00000444891zf-C2H2PF00096.262e-2436
ENSP00000444891zf-C2H2PF00096.262e-2446
ENSP00000444891zf-C2H2PF00096.262e-2456
ENSP00000444891zf-C2H2PF00096.262e-2466
ENSP00000452787zf-C2H2PF00096.262.8e-2416
ENSP00000452787zf-C2H2PF00096.262.8e-2426
ENSP00000452787zf-C2H2PF00096.262.8e-2436
ENSP00000452787zf-C2H2PF00096.262.8e-2446
ENSP00000452787zf-C2H2PF00096.262.8e-2456
ENSP00000452787zf-C2H2PF00096.262.8e-2466
ENSP00000391612zf-C2H2PF00096.262.9e-2416
ENSP00000391612zf-C2H2PF00096.262.9e-2426
ENSP00000391612zf-C2H2PF00096.262.9e-2436
ENSP00000391612zf-C2H2PF00096.262.9e-2446
ENSP00000391612zf-C2H2PF00096.262.9e-2456
ENSP00000391612zf-C2H2PF00096.262.9e-2466
ENSP00000319248zf-C2H2PF00096.263.2e-2416
ENSP00000319248zf-C2H2PF00096.263.2e-2426
ENSP00000319248zf-C2H2PF00096.263.2e-2436
ENSP00000319248zf-C2H2PF00096.263.2e-2446
ENSP00000319248zf-C2H2PF00096.263.2e-2456
ENSP00000319248zf-C2H2PF00096.263.2e-2466
ENSP00000354487zf-C2H2PF00096.263.2e-2416
ENSP00000354487zf-C2H2PF00096.263.2e-2426
ENSP00000354487zf-C2H2PF00096.263.2e-2436
ENSP00000354487zf-C2H2PF00096.263.2e-2446
ENSP00000354487zf-C2H2PF00096.263.2e-2456
ENSP00000354487zf-C2H2PF00096.263.2e-2466
ENSP00000453674zf-C2H2PF00096.266.4e-1714
ENSP00000453674zf-C2H2PF00096.266.4e-1724
ENSP00000453674zf-C2H2PF00096.266.4e-1734
ENSP00000453674zf-C2H2PF00096.266.4e-1744
ENSP00000453970zf-C2H2PF00096.267.2e-1714
ENSP00000453970zf-C2H2PF00096.267.2e-1724
ENSP00000453970zf-C2H2PF00096.267.2e-1734
ENSP00000453970zf-C2H2PF00096.267.2e-1744
ENSP00000415961zf-C2H2PF00096.261.4e-1614
ENSP00000415961zf-C2H2PF00096.261.4e-1624
ENSP00000415961zf-C2H2PF00096.261.4e-1634
ENSP00000415961zf-C2H2PF00096.261.4e-1644
ENSP00000453559zf-C2H2PF00096.261.5e-0812
ENSP00000453559zf-C2H2PF00096.261.5e-0822
ENSP00000444891zf-metPF12874.72e-0812
ENSP00000444891zf-metPF12874.72e-0822
ENSP00000452787zf-metPF12874.72.7e-0812
ENSP00000452787zf-metPF12874.72.7e-0822
ENSP00000391612zf-metPF12874.72.8e-0812
ENSP00000391612zf-metPF12874.72.8e-0822
ENSP00000319248zf-metPF12874.73.1e-0812
ENSP00000319248zf-metPF12874.73.1e-0822
ENSP00000354487zf-metPF12874.73.1e-0812
ENSP00000354487zf-metPF12874.73.1e-0822
ENSP00000453674zf-metPF12874.73.7e-0512
ENSP00000453674zf-metPF12874.73.7e-0522
ENSP00000453970zf-metPF12874.74.1e-0512
ENSP00000453970zf-metPF12874.74.1e-0522
ENSP00000415961zf-metPF12874.70.0008911

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
25261470MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor ZEB1 and the protein kinase AKT.J Biol Chem2014 Nov 7Al-Khalaf HHdoi: 10.1074/jbc.M114.593004
27682981Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.J Cell Physiol2017 JunMatos MLdoi: 10.1002/jcp.25622
30824187LBX2-AS1 is activated by ZEB1 and promotes the development of esophageal squamous cell carcinoma by interacting with HNRNPC toenhance the stability of ZEB1 and ZEB2 mRNAs.Biochem Biophys Res Commun2019 Apr 9Zhang Ydoi: 10.1016/j.bbrc.2019.02.079
29559603[Expression of H19 long non-coding RNA and ZEB1 in the trophoblast of women with spontaneous abortion].Zhong Nan Da Xue Xue Bao Yi Xue Ban2018 Feb 28Hu Ldoi: 10.11817/j.issn.1672-7347.2018.02.013.
30794031KCNQ1OT1/miR-217/ZEB1 feedback loop facilitates cell migration and epithelial-mesenchymal transition in colorectal cancer.Cancer Biol Ther2019Bian Ydoi: 10.1080/15384047.2019.1579959
28415044Long non-coding RNA SNHG1 regulates zinc finger E-box binding homeobox 1 expression by interacting with TAp63 and promotes cell metastasis and invasion in Lung squamous cell carcinoma.Biomed Pharmacother2017 JunZhang HYdoi: 10.1016/j.biopha.2017.03.104
28683446LncRNA SNHG6 is Associated with Poor Prognosis of Gastric Cancer and Promotes Cell Proliferation and EMT through Epigenetically Silencing p27 and Sponging miR-101-3p.Cell Physiol Biochem2017Yan Kdoi: 10.1159/000478682
28843520The long non-coding RNA MIAT regulates zinc finger E-box binding homeobox 1 expression by sponging miR-150 and promoteing cell invasion in non-small-cell lung cancer.Gene2017 Oct 30Zhang HYdoi: 10.1016/j.gene.2017.08.009
29295724Long Noncoding RNA CAT104 Promotes Cell Viability, Migration, and Invasion in Gastric Carcinoma Cells Through Activation of MicroRNA-381-Inhibiting Zinc Finger E-box-Binding Homeobox 1 (ZEB1) Expression.Oncol Res2018 Aug 23Yuan Gdoi: 10.3727/096504017X15144748428127
29771411Long non-coding RNA ZEB1-AS1 is associated with poor prognosis in gastric cancer and promotes cancer cell metastasis.Eur Rev Med Pharmacol Sci2018 MayLiu XJdoi: 10.26355/eurrev_201805_14956.
30026848The significant prognostic value of ZEB1-AS1 up-regulation in patients with cancer.J Cancer2018 Jun 15Ni Ydoi: 10.7150/jca.25264
30651872Long non-coding RNA ZEB1-AS1 indicates poor prognosis and promotes melanoma progression through targeting miR-1224-5p.Exp Ther Med2019 JanWang Qdoi: 10.3892/etm.2018.7005
30662595Long noncoding RNA ZEB1-AS1 promotes the tumorigenesis of glioma cancer cells by modulating the miR-200c/141-ZEB1 axis.Am J Transl Res2018 Nov 15Meng L-
31027073Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients: A Meta-analysis.Medicine (Baltimore)2019 AprZhou Xdoi: 10.1097/MD.0000000000015251.
20175752ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus.Biochem J2010 Apr 14Papadopoulou Vdoi: 10.1042/BJ20091578.
22249256SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.Oncogene2012 Oct 25Byles Vdoi: 10.1038/onc.2011.612
23239884The p63 protein isoform deltaNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205.J Biol Chem2013 Feb 1Tran MNdoi: 10.1074/jbc.M112.408104
27862275Long non-coding ribonucleic acid zinc finger antisense 1 promotes the progression of colonic cancer by modulating ZEB1 expression.J Gastroenterol Hepatol2017 JunFang Cdoi: 10.1111/jgh.13646.
28445936Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer.Oncotarget2017 Apr 11Lin Jdoi: 10.18632/oncotarget.15527.
28781686MicroRNA-150 functions as an antioncogenic regulator in osteosarcoma.Oncol Lett2017 AugXu Jdoi: 10.3892/ol.2017.6393
28837147Doxorubicin upregulates CXCR4 via miR-200c/ZEB1-dependent mechanism in human cardiac mesenchymal progenitor cells.Cell Death Dis2017 Aug 24Beji Sdoi: 10.1038/cddis.2017.409.
29667486LncRNA ADPGK-AS1 promotes pancreatic cancer progression through activating ZEB1-mediated epithelial-mesenchymal transition.Cancer Biol Ther2018 Jul 3Song Sdoi: 10.1080/15384047.2018.1423912
29885843LRP4 promotes proliferation, migration, and invasion in papillary thyroid cancer.Biochem Biophys Res Commun2018 Sep 3Zhou Xdoi: 10.1016/j.bbrc.2018.06.012
30121551lncRNA ZEB1-AS1 Was Suppressed by p53 for Renal Fibrosis in Diabetic Nephropathy.Mol Ther Nucleic Acids2018 Sep 7Wang Jdoi: 10.1016/j.omtn.2018.07.012
30448056LncRNA ZEB1-AS1/miR-409-3p/ZEB1 feedback loop is involved in the progression of non-small cell lung cancer.Biochem Biophys Res Commun2018 Dec 9Qu Rdoi: 10.1016/j.bbrc.2018.11.059
30755599lncRNA ZEB1-AS1 promotes pulmonary fibrosis through ZEB1-mediated epithelial-mesenchymal transition by competitively binding miR-141-3p.Cell Death Dis2019 Feb 12Qian Wdoi: 10.1038/s41419-019-1339-1.
30827272The mechanism of miR-192 in regulating high glucose-induced MCP-1 expression in rat glomerular mesangial cells.Endocr Metab Immune Disord Drug Targets2019 Mar 1Chen Fdoi: 10.2174/1871530319666190301154640
30867319ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.Sci Transl Med2019 Mar 13Peng DHdoi: 10.1126/scitranslmed.aaq1238.
Expression