EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
COAD	chr10	133394243	Missense_Mutation	novel	L8R	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	0.19593
BRCA	DEL	0.2343	9.4498e-14
CHOL	DEL	0.1944	0.048655
COAD	DEL	0.1663	9.4741e-07
LGG	DEL	0.2651	4.3789e-20
LIHC	DEL	0.2459	5.7505e-06
LUAD	DEL	0.188	0.032471
PAAD	DEL	0.1141	0.169
READ	DEL	0.2	0.014135
SARC	DEL	0.4708	0.00010153
TGCT	DEL	0.44	9.1106e-08
THYM	DEL	0.0325	0.10563
UCS	DEL	0.2679	0.1218

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
ACC	0.00037	Kaplan-Meier Survival Analysis
HNSC	0.017	Kaplan-Meier Survival Analysis
SKCM	0.033	Kaplan-Meier Survival Analysis
PRAD	0.027	Kaplan-Meier Survival Analysis
COAD	0.0038	Kaplan-Meier Survival Analysis
PAAD	0.00025	Kaplan-Meier Survival Analysis
BLCA	0.00011	Kaplan-Meier Survival Analysis
UVM	0.0061	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000148824 (Gene tree)
Gene ID: 92170
Gene Symbol: MTG1
Alias: GTPBP7
Full Name: mitochondrial ribosome associated GTPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 27,214 bases
Position: chr10:133,394,094-133,421,307
Accession: 32159
RBP type: canonical RBP
Summary: (Mitochondrial Ribosome Associated GTPase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ENSG00000254536.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000323047	MMR_HSR1	PF01926.23	3.9e-12	1	1
ENSP00000475596	MMR_HSR1	PF01926.23	7.1e-12	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498790	MTG1-208	693	-	-	- (aa)	-	-
ENST00000317502	MTG1-201	1560	-	ENSP00000323047	334 (aa)	-	Q9BT17
ENST00000477902	MTG1-205	1283	-	ENSP00000475596	293 (aa)	-	U3KQ69
ENST00000460848	MTG1-203	2730	-	-	- (aa)	-	-
ENST00000492266	MTG1-206	413	-	-	- (aa)	-	-
ENST00000432508	MTG1-202	953	-	ENSP00000393480	283 (aa)	-	E7EVK2
ENST00000495014	MTG1-207	871	-	-	- (aa)	-	-
ENST00000473735	MTG1-204	2212	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000148824's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000148824	Bronchodilator Agents	4E-6	26634245
ENSG00000148824	Lung Volume Measurements	4E-6	26634245
ENSG00000148824	Lupus Erythematosus, Systemic	3E-6	24871463

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000148824	rs188724679	10	133411351	C	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.43	GO_0097366\|EFO_0004713
ENSG00000148824	rs10857712	10	133412162	T	Systemic lupus erythematosus	24871463	[1.39-1.64]	1.5129	EFO_0002690

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000148824's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000148824	MTG1	95	63.345	ENSAPOG00000003960	mtg1	99	64.317	Acanthochromis_polyacanthus
ENSG00000148824	MTG1	99	83.448	ENSAMEG00000003193	-	99	79.154	Ailuropoda_melanoleuca
ENSG00000148824	MTG1	77	63.319	ENSACIG00000012614	mtg1	93	63.319	Amphilophus_citrinellus
ENSG00000148824	MTG1	95	64.769	ENSAOCG00000017208	mtg1	96	64.821	Amphiprion_ocellaris
ENSG00000148824	MTG1	95	65.480	ENSAPEG00000017169	mtg1	96	65.472	Amphiprion_percula
ENSG00000148824	MTG1	95	60.993	ENSATEG00000022220	mtg1	96	61.688	Anabas_testudineus
ENSG00000148824	MTG1	87	66.142	ENSAPLG00000014353	-	99	66.142	Anas_platyrhynchos
ENSG00000148824	MTG1	97	67.832	ENSACAG00000011844	-	99	66.565	Anolis_carolinensis
ENSG00000148824	MTG1	100	91.809	ENSANAG00000023128	-	100	92.000	Aotus_nancymaae
ENSG00000148824	MTG1	95	64.769	ENSACLG00000006398	mtg1	90	64.821	Astatotilapia_calliptera
ENSG00000148824	MTG1	95	62.116	ENSAMXG00000021084	mtg1	99	64.261	Astyanax_mexicanus
ENSG00000148824	MTG1	99	84.880	ENSBTAG00000020304	-	100	84.639	Bos_taurus
ENSG00000148824	MTG1	95	35.135	WBGene00022054	Y67D2.4	93	35.913	Caenorhabditis_elegans
ENSG00000148824	MTG1	100	92.833	ENSCJAG00000004921	-	100	92.814	Callithrix_jacchus
ENSG00000148824	MTG1	72	81.991	ENSCAFG00000029027	-	99	81.991	Canis_familiaris
ENSG00000148824	MTG1	99	83.103	ENSCAFG00020020460	-	76	84.308	Canis_lupus_dingo
ENSG00000148824	MTG1	100	83.533	ENSCHIG00000018611	-	100	83.533	Capra_hircus
ENSG00000148824	MTG1	100	91.468	ENSTSYG00000007867	-	100	90.419	Carlito_syrichta
ENSG00000148824	MTG1	97	61.053	ENSCAPG00000000299	-	99	61.053	Cavia_aperea
ENSG00000148824	MTG1	97	84.912	ENSCPOG00000030768	-	98	83.742	Cavia_porcellus
ENSG00000148824	MTG1	99	94.521	ENSCCAG00000010828	-	99	94.294	Cebus_capucinus
ENSG00000148824	MTG1	100	92.491	ENSCATG00000025147	-	100	92.491	Cercocebus_atys
ENSG00000148824	MTG1	98	84.356	ENSCLAG00000003313	-	99	84.356	Chinchilla_lanigera
ENSG00000148824	MTG1	100	92.216	ENSCSAG00000006621	-	100	92.216	Chlorocebus_sabaeus
ENSG00000148824	MTG1	87	67.059	ENSCPBG00000011654	-	91	67.059	Chrysemys_picta_bellii
ENSG00000148824	MTG1	97	46.713	ENSCING00000015202	-	92	47.841	Ciona_intestinalis
ENSG00000148824	MTG1	95	47.887	ENSCSAVG00000004569	-	96	45.706	Ciona_savignyi
ENSG00000148824	MTG1	100	93.174	ENSCANG00000032059	-	100	93.272	Colobus_angolensis_palliatus
ENSG00000148824	MTG1	97	85.866	ENSCGRG00000014611	Mtg1	99	84.568	Cricetulus_griseus_crigri
ENSG00000148824	MTG1	95	57.295	ENSCSEG00000007158	mtg1	97	57.705	Cynoglossus_semilaevis
ENSG00000148824	MTG1	95	66.192	ENSCVAG00000003927	mtg1	96	66.450	Cyprinodon_variegatus
ENSG00000148824	MTG1	81	61.345	ENSDARG00000069386	mtg1	100	62.774	Danio_rerio
ENSG00000148824	MTG1	97	83.860	ENSDNOG00000023844	-	82	80.259	Dasypus_novemcinctus
ENSG00000148824	MTG1	98	85.017	ENSDORG00000009355	Mtg1	92	83.444	Dipodomys_ordii
ENSG00000148824	MTG1	95	46.341	FBgn0039020	CG17141	96	46.006	Drosophila_melanogaster
ENSG00000148824	MTG1	95	54.093	ENSEBUG00000000594	mtg1	99	53.571	Eptatretus_burgeri
ENSG00000148824	MTG1	99	89.273	ENSEASG00005015107	-	96	88.485	Equus_asinus_asinus
ENSG00000148824	MTG1	100	87.043	ENSECAG00000014887	-	100	86.550	Equus_caballus
ENSG00000148824	MTG1	64	83.511	ENSEEUG00000011899	-	98	83.511	Erinaceus_europaeus
ENSG00000148824	MTG1	95	62.633	ENSELUG00000009753	mtg1	97	62.460	Esox_lucius
ENSG00000148824	MTG1	99	86.897	ENSFCAG00000029471	-	99	86.897	Felis_catus
ENSG00000148824	MTG1	95	64.539	ENSFALG00000013031	-	99	64.236	Ficedula_albicollis
ENSG00000148824	MTG1	100	80.546	ENSFDAG00000014305	-	100	79.641	Fukomys_damarensis
ENSG00000148824	MTG1	92	65.314	ENSFHEG00000005082	mtg1	93	65.314	Fundulus_heteroclitus
ENSG00000148824	MTG1	95	65.480	ENSGMOG00000003500	mtg1	97	65.372	Gadus_morhua
ENSG00000148824	MTG1	95	64.516	ENSGALG00000003549	MTG1	93	63.934	Gallus_gallus
ENSG00000148824	MTG1	95	64.413	ENSGAFG00000008635	mtg1	96	64.495	Gambusia_affinis
ENSG00000148824	MTG1	95	64.769	ENSGACG00000006834	mtg1	100	63.665	Gasterosteus_aculeatus
ENSG00000148824	MTG1	95	74.194	ENSGAGG00000009492	-	99	72.843	Gopherus_agassizii
ENSG00000148824	MTG1	100	98.503	ENSGGOG00000004729	-	100	98.503	Gorilla_gorilla
ENSG00000148824	MTG1	95	64.413	ENSHBUG00000022572	mtg1	96	64.495	Haplochromis_burtoni
ENSG00000148824	MTG1	100	82.036	ENSHGLG00000009989	-	100	82.036	Heterocephalus_glaber_female
ENSG00000148824	MTG1	100	82.036	ENSHGLG00100008916	-	100	82.036	Heterocephalus_glaber_male
ENSG00000148824	MTG1	95	66.192	ENSHCOG00000016724	mtg1	99	65.300	Hippocampus_comes
ENSG00000148824	MTG1	95	64.057	ENSIPUG00000017854	mtg1	97	63.344	Ictalurus_punctatus
ENSG00000148824	MTG1	95	81.720	ENSSTOG00000000426	-	98	81.562	Ictidomys_tridecemlineatus
ENSG00000148824	MTG1	99	82.534	ENSJJAG00000020935	Mtg1	98	82.875	Jaculus_jaculus
ENSG00000148824	MTG1	95	65.125	ENSKMAG00000020048	mtg1	96	64.821	Kryptolebias_marmoratus
ENSG00000148824	MTG1	81	61.088	ENSLBEG00000014208	mtg1	100	61.088	Labrus_bergylta
ENSG00000148824	MTG1	62	67.403	ENSLACG00000002736	mtg1	99	67.403	Latimeria_chalumnae
ENSG00000148824	MTG1	81	64.706	ENSLOCG00000004254	mtg1	100	64.706	Lepisosteus_oculatus
ENSG00000148824	MTG1	97	85.915	ENSLAFG00000022156	-	99	85.846	Loxodonta_africana
ENSG00000148824	MTG1	91	92.105	ENSMFAG00000042851	-	85	92.105	Macaca_fascicularis
ENSG00000148824	MTG1	100	92.833	ENSMNEG00000031866	-	100	92.833	Macaca_nemestrina
ENSG00000148824	MTG1	100	92.833	ENSMLEG00000034394	-	100	92.905	Mandrillus_leucophaeus
ENSG00000148824	MTG1	95	64.769	ENSMAMG00000004540	mtg1	99	64.217	Mastacembelus_armatus
ENSG00000148824	MTG1	95	59.028	ENSMZEG00005003943	mtg1	90	59.554	Maylandia_zebra
ENSG00000148824	MTG1	95	64.643	ENSMGAG00000001826	-	99	64.643	Meleagris_gallopavo
ENSG00000148824	MTG1	97	86.219	ENSMAUG00000020820	Mtg1	99	84.877	Mesocricetus_auratus
ENSG00000148824	MTG1	100	90.785	ENSMICG00000043833	-	100	89.521	Microcebus_murinus
ENSG00000148824	MTG1	97	86.219	ENSMOCG00000010027	Mtg1	99	84.568	Microtus_ochrogaster
ENSG00000148824	MTG1	95	59.498	ENSMMOG00000011001	mtg1	96	60.000	Mola_mola
ENSG00000148824	MTG1	97	73.171	ENSMODG00000010450	-	93	71.642	Monodelphis_domestica
ENSG00000148824	MTG1	90	75.472	ENSMODG00000024403	-	93	73.203	Monodelphis_domestica
ENSG00000148824	MTG1	95	64.769	ENSMALG00000015822	mtg1	96	64.495	Monopterus_albus
ENSG00000148824	MTG1	97	83.392	MGP_CAROLIEiJ_G0030633	Mtg1	99	82.407	Mus_caroli
ENSG00000148824	MTG1	97	82.686	ENSMUSG00000039018	Mtg1	99	81.481	Mus_musculus
ENSG00000148824	MTG1	97	83.746	MGP_PahariEiJ_G0013838	Mtg1	99	82.099	Mus_pahari
ENSG00000148824	MTG1	97	82.686	MGP_SPRETEiJ_G0031744	Mtg1	99	81.481	Mus_spretus
ENSG00000148824	MTG1	99	85.672	ENSMLUG00000005374	-	99	85.672	Myotis_lucifugus
ENSG00000148824	MTG1	97	84.806	ENSNGAG00000004763	Mtg1	99	83.642	Nannospalax_galili
ENSG00000148824	MTG1	95	62.238	ENSNBRG00000011077	mtg1	96	62.179	Neolamprologus_brichardi
ENSG00000148824	MTG1	100	96.407	ENSNLEG00000002308	-	100	96.407	Nomascus_leucogenys
ENSG00000148824	MTG1	75	76.400	ENSMEUG00000004898	-	100	76.400	Notamacropus_eugenii
ENSG00000148824	MTG1	84	75.532	ENSOPRG00000001685	-	99	59.639	Ochotona_princeps
ENSG00000148824	MTG1	100	81.570	ENSODEG00000016890	-	100	81.437	Octodon_degus
ENSG00000148824	MTG1	95	65.480	ENSONIG00000009595	mtg1	100	65.972	Oreochromis_niloticus
ENSG00000148824	MTG1	99	80.887	ENSOCUG00000000484	-	99	79.341	Oryctolagus_cuniculus
ENSG00000148824	MTG1	95	65.836	ENSORLG00000009140	mtg1	96	65.798	Oryzias_latipes
ENSG00000148824	MTG1	95	65.836	ENSORLG00020001803	mtg1	96	65.798	Oryzias_latipes_hni
ENSG00000148824	MTG1	95	66.192	ENSORLG00015005779	mtg1	100	64.596	Oryzias_latipes_hsok
ENSG00000148824	MTG1	95	64.057	ENSOMEG00000002293	mtg1	96	64.495	Oryzias_melastigma
ENSG00000148824	MTG1	96	89.408	ENSOGAG00000008833	-	100	89.408	Otolemur_garnettii
ENSG00000148824	MTG1	100	83.582	ENSOARG00000018459	-	100	83.582	Ovis_aries
ENSG00000148824	MTG1	100	98.802	ENSPPAG00000031365	-	100	98.802	Pan_paniscus
ENSG00000148824	MTG1	99	86.897	ENSPPRG00000004650	-	99	86.897	Panthera_pardus
ENSG00000148824	MTG1	99	86.897	ENSPTIG00000011659	-	99	86.897	Panthera_tigris_altaica
ENSG00000148824	MTG1	90	83.056	ENSPTRG00000003096	-	95	83.056	Pan_troglodytes
ENSG00000148824	MTG1	100	88.963	ENSPANG00000020074	-	100	88.529	Papio_anubis
ENSG00000148824	MTG1	95	64.413	ENSPKIG00000017218	mtg1	96	64.821	Paramormyrops_kingsleyae
ENSG00000148824	MTG1	95	63.701	ENSPMGG00000020359	mtg1	99	63.091	Periophthalmus_magnuspinnatus
ENSG00000148824	MTG1	97	84.099	ENSPEMG00000000729	Mtg1	99	82.716	Peromyscus_maniculatus_bairdii
ENSG00000148824	MTG1	95	58.947	ENSPMAG00000004702	mtg1	99	58.544	Petromyzon_marinus
ENSG00000148824	MTG1	97	77.739	ENSPCIG00000017219	-	97	76.852	Phascolarctos_cinereus
ENSG00000148824	MTG1	77	63.158	ENSPFOG00000007100	mtg1	100	63.158	Poecilia_formosa
ENSG00000148824	MTG1	95	61.348	ENSPLAG00000019595	mtg1	99	60.692	Poecilia_latipinna
ENSG00000148824	MTG1	95	55.326	ENSPMEG00000005297	mtg1	100	55.882	Poecilia_mexicana
ENSG00000148824	MTG1	95	61.888	ENSPREG00000021610	mtg1	100	60.084	Poecilia_reticulata
ENSG00000148824	MTG1	72	99.048	ENSPPYG00000002846	-	100	99.065	Pongo_abelii
ENSG00000148824	MTG1	100	90.785	ENSPCOG00000012212	-	100	89.521	Propithecus_coquereli
ENSG00000148824	MTG1	99	86.552	ENSPVAG00000002683	-	99	85.801	Pteropus_vampyrus
ENSG00000148824	MTG1	95	64.769	ENSPNYG00000010344	mtg1	96	64.821	Pundamilia_nyererei
ENSG00000148824	MTG1	95	66.904	ENSPNAG00000000757	mtg1	99	65.823	Pygocentrus_nattereri
ENSG00000148824	MTG1	97	84.452	ENSRNOG00000018860	Mtg1	99	83.642	Rattus_norvegicus
ENSG00000148824	MTG1	100	93.515	ENSRBIG00000044321	-	100	93.114	Rhinopithecus_bieti
ENSG00000148824	MTG1	100	93.515	ENSRROG00000032113	-	100	93.515	Rhinopithecus_roxellana
ENSG00000148824	MTG1	82	30.712	YMR097C	-	71	30.712	Saccharomyces_cerevisiae
ENSG00000148824	MTG1	100	90.785	ENSSBOG00000032013	-	100	90.419	Saimiri_boliviensis_boliviensis
ENSG00000148824	MTG1	95	60.638	ENSSFOG00015017068	mtg1	100	62.605	Scleropages_formosus
ENSG00000148824	MTG1	95	62.278	ENSSMAG00000004779	mtg1	96	62.866	Scophthalmus_maximus
ENSG00000148824	MTG1	95	64.057	ENSSDUG00000023072	mtg1	96	64.495	Seriola_dumerili
ENSG00000148824	MTG1	95	63.701	ENSSLDG00000015858	mtg1	96	64.169	Seriola_lalandi_dorsalis
ENSG00000148824	MTG1	95	69.892	ENSSPUG00000009503	-	99	68.690	Sphenodon_punctatus
ENSG00000148824	MTG1	95	64.413	ENSSPAG00000022106	mtg1	96	64.821	Stegastes_partitus
ENSG00000148824	MTG1	99	83.221	ENSSSCG00000029088	-	99	76.453	Sus_scrofa
ENSG00000148824	MTG1	95	61.071	ENSTGUG00000004841	-	100	61.639	Taeniopygia_guttata
ENSG00000148824	MTG1	95	63.345	ENSTRUG00000013826	mtg1	97	62.783	Takifugu_rubripes
ENSG00000148824	MTG1	95	63.830	ENSTNIG00000001313	mtg1	99	63.158	Tetraodon_nigroviridis
ENSG00000148824	MTG1	99	78.966	ENSTTRG00000015833	-	99	78.248	Tursiops_truncatus
ENSG00000148824	MTG1	99	84.483	ENSUAMG00000016163	-	99	83.988	Ursus_americanus
ENSG00000148824	MTG1	52	86.755	ENSUMAG00000010253	-	50	86.755	Ursus_maritimus
ENSG00000148824	MTG1	99	83.103	ENSVVUG00000000143	-	99	83.103	Vulpes_vulpes
ENSG00000148824	MTG1	95	68.310	ENSXETG00000022149	mtg1	100	65.749	Xenopus_tropicalis
ENSG00000148824	MTG1	87	63.178	ENSXCOG00000012050	mtg1	96	57.655	Xiphophorus_couchianus
ENSG00000148824	MTG1	95	60.269	ENSXMAG00000013734	mtg1	96	60.681	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	23396448.	IDA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	23396448.	IDA	Component
GO:0005759	mitochondrial matrix	23396448.	IDA	Component
GO:0005761	mitochondrial ribosome	23396448.	IDA	Component
GO:0044065	regulation of respiratory system process	23396448.	IMP	Process
GO:0070129	regulation of mitochondrial translation	23396448.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.