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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26755331SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497.Mol Ther2016 MayDing Qdoi: 10.1038/mt.2016.9
29048646SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway.Oncol Rep2017 NovLiao Jdoi: 10.3892/or.2017.5982
25028470Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-??B, and cell-cycle progression in non-small cell lung cancer.Mol Cancer Ther2014 SepDermawan JKdoi: 10.1158/1535-7163.MCT-14-0013
28423528Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells.Oncotarget2017 Mar 28Fleyshman Ddoi: 10.18632/oncotarget.15656.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1157328366SilentnovelE514E0.28
BLCAchr1157328368Missense_MutationnovelE514K0.28
BLCAchr1157335065Splice_Regionnovel0.36
BLCAchr1157332811Frame_Shift_DelnovelT195Rfs*140.12
BLCAchr1157332388Missense_MutationNAM289I0.17
BLCAchr1157327432Missense_MutationnovelS622Y0.17
BLCAchr1157333037Silentrs774365460N153N0.45
BLCAchr1157332786Missense_Mutationrs368418155R203W0.07
BLCAchr1157331665Splice_Regionrs7771150270.38
BLCAchr1157332761Missense_MutationnovelR211L0.44
BLCAchr1157326818Missense_MutationnovelS648L0.31
BLCAchr1157331750Missense_MutationNAR381C0.13
BRCAchr1157331846Missense_MutationNAS349P0.14
BRCAchr1157333512Missense_MutationnovelK90R0.05
BRCAchr1157334526SilentNAG59G0.17
BRCAchr1157332233Missense_MutationNAS307L0.27
BRCAchr1157332396Missense_MutationnovelL287M0.13
BRCAchr1157334539Missense_MutationnovelR55P0.27
BRCAchr1157332389Missense_MutationnovelM289R0.08
BRCAchr1157326436Missense_MutationNAE701Q0.15
BRCAchr1157332151Splice_SiteNAX334_splice0.26
CESCchr1157333001Missense_MutationNAF165L0.52
CESCchr1157334468Missense_MutationNAE79K0.45
CESCchr1157332388Missense_MutationNAM289I0.48
CESCchr1157330358Missense_MutationnovelM456I0.21
CESCchr1157328371Missense_MutationnovelD513N0.32
CESCchr11573263533'UTRnovel0.21
CHOLchr1157332761Missense_MutationnovelR211L0.43
COADchr1157331769SilentNAI374I0.35
COADchr1157334471Nonsense_MutationNAR78*0.11
COADchr1157332827Missense_MutationNAA189V0.13
COADchr1157332711Missense_MutationNAK228E0.26
COADchr1157332474Missense_MutationNAP261S0.35
COADchr1157334606Missense_MutationNAK33E0.29
COADchr1157330420Missense_MutationNAP436S0.38
COADchr1157332183Missense_Mutationrs748483435R324C0.17
COADchr1157331783Missense_MutationNAR370C0.21
ESCAchr11573352135'UTRnovel0.14
GBMchr1157335107SilentnovelL5L0.07
GBMchr1157327472Nonsense_MutationnovelK609*0.08
GBMchr1157328332Missense_MutationnovelA526T0.36
GBMchr1157326453Missense_MutationnovelS695N0.23
GBMchr1157330343Missense_MutationnovelK461N0.18
GBMchr1157334502Missense_MutationnovelK67N0.05
GBMchr1157332158Missense_MutationnovelF332C0.11
GBMchr1157328335Missense_MutationnovelM525L0.34
HNSCchr1157328363SilentnovelK515K0.23
HNSCchr1157331672Missense_MutationnovelE407Q0.16
HNSCchr1157330393Missense_MutationnovelD445N0.13
HNSCchr1157326746Missense_MutationnovelS672F0.04
KIRCchr1157332435Missense_MutationNAI274L0.33
KIRPchr1157332808SilentNAT195T0.2
KIRPchr1157335079Nonsense_MutationnovelK15*0.46
LAMLchr1157330918SilentNAY411Y0.09
LGGchr1157327486Missense_MutationnovelR604M0.1
LIHCchr1157332758Missense_MutationNAG212D0.5
LUADchr1157328374SilentnovelR512R0.3
LUADchr1157334625Missense_MutationnovelS26R0.33
LUADchr11573263743'UTRnovel0.12
LUADchr1157334638Missense_MutationnovelR22L0.15
LUADchr1157332466Missense_MutationnovelI263M0.08
LUADchr1157335115Missense_MutationnovelE3K0.05
LUSCchr11573263893'UTRnovel0.16
LUSCchr1157331777Missense_MutationNAD372Y0.47
LUSCchr1157332806Frame_Shift_DelnovelG196Efs*130.1
LUSCchr1157334626Missense_MutationnovelS26I0.43
LUSCchr1157326423Nonsense_MutationnovelS705*0.12
LUSCchr1157332648Missense_MutationnovelD249H0.34
LUSCchr1157330431Splice_Regionnovel0.16
LUSCchr1157330125Missense_MutationNAN483K0.31
MESOchr11573351955'UTRnovel0.39
OVchr1157328327Missense_MutationnovelK527N0.08
OVchr1157332764Missense_MutationnovelP210L0.06
OVchr1157328414Silentrs768189674N498N0.45
OVchr1157328361Missense_MutationnovelK516M0.05
OVchr1157332276Missense_MutationnovelE293K0.06
OVchr1157326425Silentrs564469054A704A0.24
OVchr1157332429Missense_MutationnovelL276V0.33
OVchr1157332734Missense_MutationnovelP220R0.13
OVchr1157333462Missense_MutationnovelW107R0.08
OVchr1157334536Missense_MutationnovelV56G0.07
OVchr1157333446Missense_MutationnovelV112A0.1
OVchr1157328305Missense_MutationNAP535S0.55
OVchr1157330125Missense_MutationNAN483K0.29
PAADchr1157330916Missense_MutationnovelG412E0.15
PAADchr1157334649Splice_SitenovelX19_splice0.17
PRADchr1157328355Missense_MutationnovelK518R0.07
PRADchr1157326716Missense_MutationNAR682K0.47
PRADchr1157327490Missense_MutationnovelA603S0.07
PRADchr1157327752Missense_MutationnovelA581V0.42
PRADchr1157331749Missense_MutationNAR381H0.5
READchr1157326811Missense_MutationnovelK650N0.47
SKCMchr1157332690Missense_MutationNAP235S0.19
SKCMchr1157327796Missense_MutationNAK566N0.45
SKCMchr1157332157SilentNAF332F0.57
SKCMchr1157326840Missense_MutationNAS641T0.13
SKCMchr1157333540Missense_MutationnovelE81K0.3
SKCMchr1157330115Missense_MutationNAE487K0.36
SKCMchr1157332224Missense_MutationNAL310P0.3
SKCMchr1157332226Silentrs200954961S309S0.16
SKCMchr1157332227Missense_MutationnovelS309F0.16
SKCMchr1157332691SilentnovelI234I0.25
SKCMchr1157334540Missense_MutationnovelR55G0.57
STADchr1157326449SilentNAT696T0.13
STADchr1157331822Missense_MutationNAR357W0.16
STADchr1157327805Missense_MutationNAE563D0.27
STADchr1157332481SilentNAS258S0.1
STADchr1157332752Missense_MutationNAY214C0.13
STADchr1157331749Missense_MutationNAR381H0.11
STADchr1157333021Missense_MutationNAS159P0.18
UCECchr1157332263Missense_MutationNAR297H0.37
UCECchr1157330412Silentrs139702168Y438Y0.34
UCECchr1157334638Missense_MutationNAR22Q0.47
UCECchr1157326743Missense_MutationnovelS673L0.04
UCECchr1157335097Missense_MutationnovelD9N0.04
UCECchr1157326442Missense_MutationnovelS699G0.19
UCECchr1157327442Missense_MutationnovelG619S0.08
UCECchr1157330908Missense_MutationnovelF415L0.48
UCECchr1157327769Silentrs776731049T575T0.27
UCECchr11573262673'UTRnovel0.39
UCECchr1157326426Missense_MutationnovelA704V0.35
UCECchr1157333136SilentnovelS120S0.42
UCECchr1157332827Missense_MutationNAA189V0.48
UCECchr1157332182Missense_MutationNAR324H0.24
UCECchr1157332459Missense_MutationnovelG266C0.08
UCECchr1157333473Missense_MutationnovelC103Y0.03
UCECchr1157326415Missense_MutationNAD708N0.14
UCECchr1157331691Missense_MutationnovelQ400H0.53
UCECchr1157333524Missense_MutationNAS86C0.42
UCECchr1157333037Silentrs774365460N153N0.23
UCECchr1157334543Missense_MutationNAR54C0.42
UCECchr1157332642Missense_MutationnovelR251C0.17
UCECchr1157332691SilentnovelI234I0.54
UCECchr1157333532Missense_MutationnovelE83D0.32
UCECchr1157330408Nonsense_MutationnovelE440*0.37
UCECchr1157331732Missense_MutationnovelR387C0.38
UCECchr1157332224Missense_MutationnovelL310R0.45
UCECchr1157334617Missense_MutationnovelG29V0.56
UCECchr1157333093Missense_MutationNAN135D0.24
UCECchr1157334638Missense_MutationNAR22Q0.27
UCECchr1157332854Missense_MutationnovelA180V0.33
UCECchr1157333031Silentrs768771466D155D0.4
UCECchr1157333500Missense_Mutationrs377522214R94H0.17
UCECchr1157331732Missense_MutationNAR387G0.2
UCECchr1157331787SilentNAH368H0.31
UCECchr1157326805SilentnovelS652S0.56
UCECchr11573263633'UTRrs2005770920.33
UCECchr1157326871Missense_MutationNAK630N0.32
UCECchr1157327769SilentNAT575T0.37
UCECchr1157330874Missense_MutationNAK426T0.45
UCECchr1157327747Missense_MutationNAE583K0.32
UCECchr1157327768Missense_MutationnovelD576Y0.21
UCECchr1157330892Missense_Mutationrs777555591A420V0.35
UCECchr1157332182Missense_MutationNAR324H0.44
UCECchr1157332970Missense_MutationnovelD176N0.17
UCECchr1157333500Missense_Mutationrs377522214R94H0.11
UCECchr1157334526SilentnovelG59G0.08
UCECchr1157327440Silentrs530277602G619G0.33
UCECchr11573262473'UTRnovel0.35
UCECchr1157328413Missense_MutationnovelA499T0.37
UCECchr1157331750Missense_MutationNAR381C0.48
UCECchr1157332206Missense_MutationnovelR316Q0.54
UCECchr1157330891SilentNAA420A0.37
UCECchr1157332182Missense_MutationNAR324H0.36
UCSchr1157331830Missense_MutationnovelP354L0.15

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.15760.018342
TGCTDEL0.64670.21504

Survival Analysis
CancerP-value Q-value
STAD0.05

Kaplan-Meier Survival Analysis

SARC0.0011

Kaplan-Meier Survival Analysis

MESO0.00055

Kaplan-Meier Survival Analysis

ACC0.00022

Kaplan-Meier Survival Analysis

UCS0.023

Kaplan-Meier Survival Analysis

SKCM0.033

Kaplan-Meier Survival Analysis

KIRP0.00067

Kaplan-Meier Survival Analysis

PAAD0.0001

Kaplan-Meier Survival Analysis

BLCA0.021

Kaplan-Meier Survival Analysis

READ0.0036

Kaplan-Meier Survival Analysis

LAML0.0028

Kaplan-Meier Survival Analysis

KICH0.025

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LUAD0.011

Kaplan-Meier Survival Analysis

OV0.038

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000149136 (Gene tree)
Gene ID
6749
Gene Symbol
SSRP1
Alias
FACT80
Full Name
structure specific recognition protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
9,893 bases
Position
chr11:57,325,985-57,335,877
Accession
11327
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000293880SSRP1-2026296--- (aa)--
ENST00000278412SSRP1-2012819XM_017018180ENSP00000278412709 (aa)XP_016873669Q08945
ENST00000635721SSRP1-205675-ENSP00000489564225 (aa)-A0A0U1RRK2
ENST00000529002SSRP1-204648-ENSP0000043454689 (aa)-E9PPZ7
ENST00000526696SSRP1-203948-ENSP00000431154173 (aa)-E9PMD4
Gene Model
Click here to download ENSG00000149136's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149136's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000149136SSRP1100100.000ENSMUSG00000027067Ssrp110097.753Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0003677DNA binding-IEAFunction
GO:0003682chromatin binding-IEAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding16902406.19214185.19836239.22113938.25852190.30021884.IPIFunction
GO:0005654nucleoplasm-TASComponent
GO:0005694chromosome-IEAComponent
GO:0005730nucleolus-IEAComponent
GO:0006260DNA replication-IEAProcess
GO:0006281DNA repair-IEAProcess
GO:0006357regulation of transcription by RNA polymerase II-IEAProcess
GO:0006366transcription by RNA polymerase II-TASProcess
GO:0006368transcription elongation from RNA polymerase II promoter-TASProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
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