EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21091576	Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility.	Brain Pathol	2011 Jul	Petermann A	doi: 10.1111/j.1750-3639.2010.00464.x
15231692	Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo.	Carcinogenesis	2004 Nov	Trapasso F	-
19836242	An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.	Curr Biol	2009 Nov 17	Tarcic G	doi: 10.1016/j.cub.2009.09.048.
16778204	The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.	Cancer Res	2006 Jun 15	Iervolino A	-
28052032	A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.	Oncotarget	2017 Feb 7	Bilotta A	doi: 10.18632/oncotarget.14350.
21036128	Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer.	Gastroenterology	2010 Dec	Venkatachalam R	doi: 10.1053/j.gastro.2010.08.063
16000320	Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer.	Hum Mol Genet	2005 Aug 15	Lesueur F	-
25412306	Characterization of novel markers of senescence and their prognostic potential in cancer.	Cell Death Dis	2014 Nov 20	Althubiti M	doi: 10.1038/cddis.2014.489.
28316102	Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer.	J Cell Biochem	2017 Oct	Zhang XF	doi: 10.1002/jcb.25995
30661225	Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk.	J Appl Genet	2019 Feb	Laczmanska I	doi: 10.1007/s13353-019-00481-3

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	48139619	Silent	rs751724128	A762A	0.05
BLCA	chr11	48155840	Missense_Mutation	novel	S1090L	0.08
BLCA	chr11	48125033	Missense_Mutation	novel	V314M	0.22
BLCA	chr11	48127841	Silent	novel	I385I	0.28
BLCA	chr11	48137030	Missense_Mutation	NA	V634A	0.24
BLCA	chr11	48155856	Missense_Mutation	rs756360727	I1095M	0.36
BLCA	chr11	48130496	Silent	NA	V465V	0.25
BLCA	chr11	48167307	Missense_Mutation	novel	Y1320F	0.44
BLCA	chr11	48167221	Silent	rs540802430	L1291L	0.25
BLCA	chr11	48112863	Missense_Mutation	NA	Q78E	0.29
BLCA	chr11	48139772	Silent	NA	I813I	0.29
BLCA	chr11	48125009	Missense_Mutation	NA	A306T	0.07
BLCA	chr11	48137071	Missense_Mutation	novel	F648V	0.21
BLCA	chr11	48163547	Silent	rs2229704	I1216I	0.29
BLCA	chr11	48123782	Silent	novel	L262L	0.31
BRCA	chr11	48143007	Silent	rs147493496	H844H	0.04
BRCA	chr11	48153884	Missense_Mutation	novel	P1076L	0.09
BRCA	chr11	48145067	Missense_Mutation	NA	E952K	0.46
BRCA	chr11	48127890	Missense_Mutation	NA	H402Y	0.13
BRCA	chr11	48131631	Intron	novel		0.12
BRCA	chr11	48142928	Missense_Mutation	NA	P818R	0.26
BRCA	chr11	48125052	Missense_Mutation	NA	S320F	0.15
BRCA	chr11	48153866	Missense_Mutation	NA	R1070H	0.16
BRCA	chr11	48121173	Frame_Shift_Del	novel	*G175Efs2**	0.17
BRCA	chr11	48143025	Silent	NA	Y850Y	0.34
CESC	chr11	48130481	Silent	novel	F460F	0.12
CESC	chr11	48136217	Silent	rs369760760	P598P	0.42
CESC	chr11	48139676	Silent	rs768525817	T781T	0.62
CESC	chr11	48164381	Missense_Mutation	novel	A1241T	0.34
CESC	chr11	48164509	Silent	NA	Q1283Q	0.4
CESC	chr11	48136241	Missense_Mutation	NA	I606M	0.29
CESC	chr11	48160028	Missense_Mutation	novel	I1179M	0.26
COAD	chr11	48160025	Silent	NA	T1178T	0.18
COAD	chr11	48128017	Missense_Mutation	rs761076895	T444M	0.19
COAD	chr11	48121245	Missense_Mutation	novel	R199G	0.37
COAD	chr11	48145049	Missense_Mutation	novel	G946R	0.26
COAD	chr11	48125009	Missense_Mutation	NA	A306T	0.18
COAD	chr11	48155865	Silent	NA	N1098N	0.3
COAD	chr11	48136217	Silent	rs369760760	P598P	0.27
COAD	chr11	48112926	Missense_Mutation	novel	P99S	0.16
COAD	chr11	48136111	Missense_Mutation	rs767845396	P563L	0.33
COAD	chr11	48167399	3'UTR	rs752823847		0.08
COAD	chr11	48167245	Silent	novel	V1299V	0.05
COAD	chr11	48121073	Silent	novel	S141S	0.34
COAD	chr11	48146892	Silent	rs752139572	A976A	0.06
COAD	chr11	48167602	3'UTR	novel		0.5
COAD	chr11	48136074	Missense_Mutation	rs769547786	V551I	0.09
COAD	chr11	48139759	Missense_Mutation	NA	C809Y	0.4
COAD	chr11	48123757	Missense_Mutation	rs148218497	R254I	0.23
COAD	chr11	48137124	Silent	NA	G665G	0.29
COAD	chr11	48136073	Silent	rs148782546	Y550Y	0.36
COAD	chr11	48156054	Missense_Mutation	rs536396969	R1125C	0.28
COAD	chr11	48139619	Silent	rs751724128	A762A	0.29
COAD	chr11	48130650	Missense_Mutation	NA	F517L	0.43
ESCA	chr11	48167402	3'UTR	rs764199276		0.48
ESCA	chr11	48110077	Splice_Site	novel	X39_splice	0.43
ESCA	chr11	48139568	Silent	rs755561818	G745G	0.16
GBM	chr11	48137181	Frame_Shift_Del	novel	*T685Lfs3**	0.03
GBM	chr11	48137137	Missense_Mutation	rs200255695	A670T	0.21
GBM	chr11	48144767	Nonsense_Mutation	novel	E890*	0.47
GBM	chr11	48155800	Splice_Site	novel	X1077_splice	0.22
GBM	chr11	48127874	Missense_Mutation	novel	N396K	0.26
GBM	chr11	48145061	Frame_Shift_Del	novel	*A951Lfs38**	0.09
GBM	chr11	48123812	Silent	rs770215254	P272P	0.14
GBM	chr11	48163566	Missense_Mutation	rs746784211	R1223C	0.23
GBM	chr11	48112844	Missense_Mutation	novel	Q71H	0.27
GBM	chr11	48139676	Silent	rs768525817	T781T	0.07
GBM	chr11	48156092	Missense_Mutation	novel	M1137I	0.06
HNSC	chr11	48146944	Missense_Mutation	novel	I994V	0.47
HNSC	chr11	48136106	Missense_Mutation	novel	K561N	0.19
HNSC	chr11	48145095	Nonsense_Mutation	novel	S961*	0.08
HNSC	chr11	48159940	Missense_Mutation	novel	E1150V	0.1
HNSC	chr11	48137027	Missense_Mutation	novel	D633A	0.11
HNSC	chr11	48146873	Splice_Region	novel		0.27
HNSC	chr11	48127832	Silent	rs145270865	L382L	0.26
HNSC	chr11	48123819	Missense_Mutation	novel	L275V	0.29
HNSC	chr11	48144838	Silent	novel	T913T	0.21
HNSC	chr11	48160038	Missense_Mutation	novel	T1183S	0.64
KIRC	chr11	48167351	Missense_Mutation	novel	Y1335N	0.34
KIRC	chr11	48144689	Missense_Mutation	NA	A864T	0.1
KIRC	chr11	48130549	Missense_Mutation	NA	Q483R	0.42
KIRC	chr11	48121225	Missense_Mutation	rs61737868	N192S	0.38
KIRC	chr11	48144716	Missense_Mutation	NA	D873Y	0.28
KIRC	chr11	48131677	Intron	novel		0.3
KIRP	chr11	48160034	Missense_Mutation	NA	D1181E	0.38
KIRP	chr11	48121209	Missense_Mutation	NA	T187A	0.29
KIRP	chr11	48164440	Missense_Mutation	novel	E1260D	0.06
KIRP	chr11	48121176	Missense_Mutation	NA	L176V	0.41
KIRP	chr11	48121000	Splice_Region	novel		0.26
KIRP	chr11	48127951	Missense_Mutation	NA	P422L	0.34
LAML	chr11	48164401	Silent	novel	G1247G	0.04
LAML	chr11	48163589	Silent	novel	P1230P	0.07
LAML	chr11	48137172	Silent	rs140686417	D681D	0.48
LAML	chr11	48121201	Missense_Mutation	novel	F184S	0.11
LAML	chr11	48112789	Frame_Shift_Del	novel	*T53Kfs6**	0.05
LAML	chr11	48112790	Silent	novel	T53T	0.06
LGG	chr11	48127978	Missense_Mutation	rs561061051	N431S	0.45
LGG	chr11	48130638	Missense_Mutation	NA	T513A	0.48
LGG	chr11	48112803	Missense_Mutation	novel	I58V	0.45
LGG	chr11	48159963	Missense_Mutation	novel	A1158T	0.05
LIHC	chr11	48163619	Splice_Site	NA	X1240_splice	0.54
LIHC	chr11	48121027	Missense_Mutation	novel	K126R	0.45
LIHC	chr11	48167283	Missense_Mutation	novel	Q1312R	0.2
LUAD	chr11	48159990	Missense_Mutation	NA	A1167S	0.32
LUAD	chr11	48136259	Silent	rs747722144	H612H	0.06
LUAD	chr11	48164453	Missense_Mutation	NA	V1265L	0.42
LUAD	chr11	48137129	Missense_Mutation	NA	S667F	0.08
LUAD	chr11	48121152	Nonsense_Mutation	novel	Q168*	0.21
LUAD	chr11	48156055	Missense_Mutation	novel	R1125L	0.26
LUAD	chr11	48112979	Frame_Shift_Del	novel	*T117Wfs7**	0.09
LUAD	chr11	48124992	Missense_Mutation	NA	R300L	0.14
LUAD	chr11	48164474	Missense_Mutation	novel	Y1272H	0.14
LUAD	chr11	48163608	Missense_Mutation	novel	V1237L	0.41
LUAD	chr11	48164430	Missense_Mutation	NA	Y1257C	0.22
LUAD	chr11	48125093	Missense_Mutation	NA	G334W	0.19
LUAD	chr11	48156087	Missense_Mutation	novel	I1136V	0.07
LUSC	chr11	48137063	Missense_Mutation	novel	W645L	0.13
LUSC	chr11	48167378	3'UTR	novel		0.32
LUSC	chr11	48137128	Missense_Mutation	NA	S667P	0.36
LUSC	chr11	48123637	Missense_Mutation	NA	R214L	0.74
LUSC	chr11	48142917	Splice_Site	NA	X815_splice	0.35
LUSC	chr11	48136076	Silent	novel	V551V	0.05
LUSC	chr11	48144757	Silent	novel	L886L	0.28
LUSC	chr11	48137079	Silent	rs763072219	D650D	0.2
LUSC	chr11	48136181	Silent	novel	T586T	0.13
LUSC	chr11	48125040	Missense_Mutation	NA	P316L	0.3
LUSC	chr11	48144855	Missense_Mutation	NA	N919S	0.39
LUSC	chr11	48128021	Silent	NA	P445P	0.15
LUSC	chr11	48125048	Missense_Mutation	novel	P319S	0.28
LUSC	chr11	48139631	Missense_Mutation	novel	E766D	0.29
LUSC	chr11	48167389	3'UTR	novel		0.17
LUSC	chr11	48136053	Missense_Mutation	novel	F544L	0.42
LUSC	chr11	48139485	Splice_Site	novel	X718_splice	0.37
LUSC	chr11	48137002	Splice_Site	novel	X625_splice	0.15
LUSC	chr11	48144821	Missense_Mutation	novel	V908F	0.26
LUSC	chr11	48124982	Nonsense_Mutation	novel	E297*	0.15
OV	chr11	48164397	Missense_Mutation	novel	T1246K	0.04
OV	chr11	48167373	3'UTR	novel		0.17
OV	chr11	48125105	Missense_Mutation	NA	G338S	0.25
OV	chr11	48142922	Missense_Mutation	novel	P816L	0.13
OV	chr11	48145088	Missense_Mutation	novel	R959G	0.09
OV	chr11	48137083	Missense_Mutation	novel	S652P	0.06
OV	chr11	48144806	Missense_Mutation	novel	K903Q	0.03
OV	chr11	48167461	3'UTR	novel		0.12
OV	chr11	48136126	Missense_Mutation	novel	E568G	0.07
OV	chr11	48146940	Silent	NA	G992G	0.09
OV	chr11	48136133	Silent	novel	V570V	0.07
PAAD	chr11	48127886	Silent	novel	K400K	0.04
PAAD	chr11	48139615	Missense_Mutation	rs763253994	N761S	0.17
PRAD	chr11	48139586	Silent	rs748999792	E751E	0.08
PRAD	chr11	48123685	Missense_Mutation	novel	G230D	0.38
READ	chr11	48150117	Silent	NA	E1024E	0.27
READ	chr11	48121144	Missense_Mutation	novel	V165A	0.05
READ	chr11	48123837	Missense_Mutation	novel	K281Q	0.18
READ	chr11	48139619	Silent	rs751724128	A762A	0.38
READ	chr11	48150181	Missense_Mutation	rs765457377	E1046K	0.41
READ	chr11	48156032	Silent	NA	P1117P	0.25
SARC	chr11	48155811	Silent	novel	S1080S	0.26
SKCM	chr11	48130474	Missense_Mutation	NA	S458F	0.25
SKCM	chr11	48144857	Missense_Mutation	NA	G920W	0.26
SKCM	chr11	48136136	Silent	NA	Y571Y	0.28
SKCM	chr11	48130481	Silent	novel	F460F	0.17
SKCM	chr11	48139669	Missense_Mutation	NA	E779V	0.24
SKCM	chr11	48164484	Missense_Mutation	NA	R1275Q	0.11
SKCM	chr11	48155996	Silent	NA	S1105S	0.38
SKCM	chr11	48136216	Missense_Mutation	rs377252468	P598L	0.44
SKCM	chr11	48136262	Silent	NA	V613V	0.37
SKCM	chr11	48155982	Splice_Region	novel		0.11
SKCM	chr11	48137074	Missense_Mutation	NA	D649N	0.14
SKCM	chr11	48142921	Missense_Mutation	NA	P816S	0.32
SKCM	chr11	48112865	Silent	novel	Q78Q	0.18
SKCM	chr11	48139502	Silent	novel	A723A	0.11
SKCM	chr11	48123735	Missense_Mutation	NA	E247K	0.41
SKCM	chr11	48136274	Silent	novel	P617P	0.31
SKCM	chr11	48127950	Missense_Mutation	NA	P422S	0.39
SKCM	chr11	48125103	Missense_Mutation	NA	P337L	0.26
SKCM	chr11	48163600	Missense_Mutation	NA	P1234L	0.2
SKCM	chr11	48146939	Missense_Mutation	NA	G992D	0.19
SKCM	chr11	48112832	Silent	novel	S67S	0.41
SKCM	chr11	48112911	Missense_Mutation	rs759543022	D94N	0.55
SKCM	chr11	48142918	Splice_Site	novel	X817_splice	0.41
SKCM	chr11	48124993	Silent	novel	R300R	0.48
SKCM	chr11	48136137	Missense_Mutation	NA	H572Y	0.25
SKCM	chr11	48167323	Silent	novel	P1325P	0.33
SKCM	chr11	48123769	Missense_Mutation	NA	N258S	0.45
SKCM	chr11	48156066	Nonsense_Mutation	NA	E1129*	0.43
STAD	chr11	48155800	Splice_Site	NA	X1077_splice	0.11
STAD	chr11	48112824	Missense_Mutation	NA	A65T	0.09
STAD	chr11	48144716	Missense_Mutation	rs755218393	D873N	0.18
STAD	chr11	48127799	Silent	rs780863107	D371D	0.27
STAD	chr11	48125009	Missense_Mutation	NA	A306T	0.09
STAD	chr11	48125009	Missense_Mutation	NA	A306T	0.3
STAD	chr11	48130496	Silent	NA	V465V	0.23
STAD	chr11	48145109	Missense_Mutation	novel	L966V	0.4
STAD	chr11	48139741	Frame_Shift_Del	novel	*T805Pfs29**	0.22
STAD	chr11	48150113	Missense_Mutation	NA	V1023A	0.06
STAD	chr11	48150095	Splice_Site	NA	X1017_splice	0.44
STAD	chr11	48167319	Missense_Mutation	rs199803858	A1324V	0.24
STAD	chr11	48167413	3'UTR	rs191012650		0.37
STAD	chr11	48155822	Missense_Mutation	novel	L1084R	0.3
STAD	chr11	48110067	Missense_Mutation	NA	A36T	0.25
STAD	chr11	48125013	Missense_Mutation	NA	P307H	0.09
STAD	chr11	48145081	Silent	NA	S956S	0.08
STAD	chr11	48163614	Missense_Mutation	NA	C1239R	0.1
STAD	chr11	48139561	Missense_Mutation	NA	P743H	0.22
STAD	chr11	48127898	Frame_Shift_Del	novel	*E406Rfs33**	0.35
STAD	chr11	48156054	Missense_Mutation	rs536396969	R1125C	0.39
STAD	chr11	48156055	Missense_Mutation	rs374260795	R1125H	0.05
STAD	chr11	48123621	Missense_Mutation	NA	P209T	0.15
STAD	chr11	48136264	Frame_Shift_Del	NA	*D616Tfs19**	0.15
STAD	chr11	48136182	Missense_Mutation	NA	Y587H	0.27
STAD	chr11	48167350	Silent	NA	G1334G	0.34
STAD	chr11	48144820	Silent	rs532049445	D907D	0.25
STAD	chr11	48137128	Missense_Mutation	NA	S667P	0.36
STAD	chr11	48137030	Missense_Mutation	NA	V634A	0.12
STAD	chr11	48125009	Missense_Mutation	NA	A306T	0.1
STAD	chr11	48127865	Silent	rs748897376	S393S	0.3
STAD	chr11	48123625	Missense_Mutation	NA	V210A	0.21
STAD	chr11	48123696	Missense_Mutation	NA	A234T	0.33
STAD	chr11	48130504	Missense_Mutation	rs140690947	T468M	0.14
STAD	chr11	48123730	Missense_Mutation	rs753741250	S245N	0.35
THCA	chr11	48125156	Missense_Mutation	NA	G355R	0.14
UCEC	chr11	48156032	Silent	NA	P1117P	0.28
UCEC	chr11	48123617	Silent	rs137863628	P207P	0.27
UCEC	chr11	48139515	Missense_Mutation	rs181029182	E728K	0.28
UCEC	chr11	48163601	Silent	rs753492303	P1234P	0.35
UCEC	chr11	48112811	Missense_Mutation	novel	Q60H	0.27
UCEC	chr11	48136172	Silent	novel	H583H	0.12
UCEC	chr11	48137261	Missense_Mutation	novel	G711D	0.24
UCEC	chr11	48144716	Missense_Mutation	rs755218393	D873N	0.56
UCEC	chr11	48145089	Missense_Mutation	rs183923997	R959H	0.29
UCEC	chr11	48156018	Missense_Mutation	novel	Q1113E	0.19
UCEC	chr11	48167357	Missense_Mutation	rs200505007	A1337T	0.41
UCEC	chr11	48150140	Missense_Mutation	novel	K1032T	0.49
UCEC	chr11	48142940	Missense_Mutation	novel	S822F	0.36
UCEC	chr11	48139605	Missense_Mutation	NA	A758T	0.46
UCEC	chr11	48124974	Missense_Mutation	novel	S294I	0.4
UCEC	chr11	48139667	Silent	rs771594321	T778T	0.39
UCEC	chr11	48153866	Missense_Mutation	NA	R1070H	0.22
UCEC	chr11	48160004	Missense_Mutation	novel	E1171D	0.35
UCEC	chr11	48139697	Silent	rs774412163	S788S	0.43
UCEC	chr11	48160044	Missense_Mutation	NA	K1185E	0.47
UCEC	chr11	48121083	Missense_Mutation	rs766468331	A145T	0.12
UCEC	chr11	48130585	Missense_Mutation	NA	R495Q	0.33
UCEC	chr11	48163527	Missense_Mutation	rs777452594	D1210N	0.21
UCEC	chr11	48167402	3'UTR	rs764199276		0.19
UCEC	chr11	48164484	Missense_Mutation	NA	R1275Q	0.39
UCEC	chr11	48167428	3'UTR	rs73452004		0.58
UCEC	chr11	48125101	Missense_Mutation	NA	E336D	0.43
UCEC	chr11	48137173	Missense_Mutation	rs373520236	A682T	0.42
UCEC	chr11	48160030	Missense_Mutation	NA	R1180I	0.37
UCEC	chr11	48131514	Intron	novel		0.4
UCEC	chr11	48153862	Missense_Mutation	novel	N1069H	0.33
UCEC	chr11	48137173	Missense_Mutation	rs373520236	A682T	0.13
UCEC	chr11	48124986	Missense_Mutation	novel	R298K	0.25
UCEC	chr11	48136289	Silent	novel	Q622Q	0.29
UCEC	chr11	48145117	Missense_Mutation	novel	Q968H	0.42
UCEC	chr11	48167434	3'UTR	novel		0.22
UCEC	chr11	48123696	Missense_Mutation	NA	A234T	0.4
UCEC	chr11	48127865	Silent	rs748897376	S393S	0.49
UCEC	chr11	48137080	Missense_Mutation	rs184451413	A651T	0.32
UCEC	chr11	48139668	Missense_Mutation	novel	E779K	0.4
UCEC	chr11	48145097	Missense_Mutation	novel	D962Y	0.52
UCEC	chr11	48160002	Nonsense_Mutation	novel	E1171*	0.42
UCEC	chr11	48127859	Silent	rs147639990	N391N	0.37
UCEC	chr11	48139515	Missense_Mutation	rs181029182	E728K	0.38
UCEC	chr11	48121065	Missense_Mutation	novel	W139R	0.1
UCEC	chr11	48136288	Missense_Mutation	novel	Q622R	0.2
UCEC	chr11	48144762	Missense_Mutation	novel	R888K	0.44
UCEC	chr11	48139514	Silent	rs559753032	C727C	0.45
UCEC	chr11	48150130	In_Frame_Ins	novel	K1032_Q1033insSVFIGRRVEHDKEANFKK	0.02
UCEC	chr11	48163593	Missense_Mutation	rs549361841	E1232K	0.12
UCEC	chr11	48153864	Silent	novel	N1069N	0.27
UCEC	chr11	48164484	Missense_Mutation	NA	R1275Q	0.29
UCEC	chr11	48125153	Nonsense_Mutation	NA	E354*	0.48
UCEC	chr11	48139509	Missense_Mutation	rs374727162	D726N	0.42
UCEC	chr11	48123705	Missense_Mutation	rs374139660	R237W	0.33
UCEC	chr11	48127904	Missense_Mutation	novel	E406D	0.38
UCEC	chr11	48137217	Missense_Mutation	novel	E696D	0.44
UCEC	chr11	48131512	Intron	novel		0.08
UCEC	chr11	48163567	Missense_Mutation	rs144070412	R1223H	0.33
UCEC	chr11	48139676	Silent	rs768525817	T781T	0.33
UCEC	chr11	48163476	Missense_Mutation	novel	H1193Y	0.04
UCEC	chr11	48121015	Missense_Mutation	novel	V122A	0.27
UCEC	chr11	48167319	Missense_Mutation	rs199803858	A1324V	0.33
UCEC	chr11	48167423	3'UTR	novel		0.6
UCEC	chr11	48131579	Intron	novel		0.31
UCEC	chr11	48156055	Missense_Mutation	rs374260795	R1125H	0.14
UCEC	chr11	48164484	Missense_Mutation	NA	R1275Q	0.22
UCEC	chr11	48163566	Missense_Mutation	rs746784211	R1223C	0.29
UCEC	chr11	48159994	Missense_Mutation	NA	M1168T	0.54
UCEC	chr11	48121118	Missense_Mutation	NA	K156N	0.28
UCEC	chr11	48167309	Nonsense_Mutation	novel	E1321*	0.25
UCEC	chr11	48144748	Silent	novel	V883V	0.42
UCEC	chr11	48136076	Silent	NA	V551V	0.34
UCEC	chr11	48139736	Frame_Shift_Ins	novel	*A802Efs26**	0.1
UCEC	chr11	48139738	Missense_Mutation	novel	A802V	0.08
UCEC	chr11	48125009	Missense_Mutation	NA	A306T	0.51
UCEC	chr11	48125161	Missense_Mutation	novel	Q356H	0.25
UCEC	chr11	48136186	Missense_Mutation	novel	D588A	0.18
UCEC	chr11	48137080	Missense_Mutation	rs184451413	A651T	0.45
UCEC	chr11	48139671	Missense_Mutation	novel	V780F	0.23
UCEC	chr11	48156029	Silent	novel	L1116L	0.17
UCEC	chr11	48144705	Missense_Mutation	novel	Y869S	0.17
UCEC	chr11	48153866	Missense_Mutation	NA	R1070H	0.54
UCEC	chr11	48125169	Missense_Mutation	NA	A359V	0.23
UCEC	chr11	48127779	Splice_Site	NA	X365_splice	0.26
UCEC	chr11	48112808	Silent	rs146294071	T59T	0.39
UCEC	chr11	48124986	Missense_Mutation	novel	R298I	0.48
UCEC	chr11	48130550	Silent	novel	Q483Q	0.65
UCEC	chr11	48136206	Missense_Mutation	novel	G595S	0.5
UCEC	chr11	48130621	Missense_Mutation	rs374658783	G507D	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1522	0.018342
PRAD	DEL	0.0569	0.0050014
TGCT	DEL	0.6133	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0021	Kaplan-Meier Survival Analysis
KIRC	0.025	Kaplan-Meier Survival Analysis
STAD	0.0085	Kaplan-Meier Survival Analysis
HNSC	0.048	Kaplan-Meier Survival Analysis
PCPG	0.025	Kaplan-Meier Survival Analysis
GBM	0.05	Kaplan-Meier Survival Analysis
CHOL	0.012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000149177 (Gene tree)
Gene ID: 5795
Gene Symbol: PTPRJ
Alias: DEP1|HPTPeta|CD148
Full Name: protein tyrosine phosphatase receptor type J
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 190,285 bases
Position: chr11:47,980,558-48,170,842
Accession: 9673
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000527952	PTPRJ-205	626	-	ENSP00000435618	146 (aa)	-	E9PJ83
ENST00000527026	PTPRJ-204	555	-	-	- (aa)	-	-
ENST00000526550	PTPRJ-203	571	-	-	- (aa)	-	-
ENST00000418331	PTPRJ-201	5122	XM_017018083	ENSP00000400010	1337 (aa)	XP_016873572	Q12913
ENST00000615445	PTPRJ-208	4773	-	ENSP00000479342	1342 (aa)	-	A0A087WVC6
ENST00000613246	PTPRJ-207	7851	-	ENSP00000477933	1338 (aa)	-	A0A087WTK0
ENST00000534219	PTPRJ-206	546	-	ENSP00000432686	120 (aa)	-	E9PPH3
ENST00000440289	PTPRJ-202	3158	-	ENSP00000409733	539 (aa)	-	Q12913

Gene Model

Click here to download ENSG00000149177's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04520	Adherens junction	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000149177	Cholesterol, HDL	9.17e-005	19060910
ENSG00000149177	Cholesterol, HDL	1.347e-006	19060910
ENSG00000149177	Platelet Function Tests	5.2800000E-006	-
ENSG00000149177	Autistic Disorder	5.0689000E-005	-
ENSG00000149177	Autistic Disorder	5.0689000E-005	-
ENSG00000149177	Autistic Disorder	4.0662000E-005	-
ENSG00000149177	Autistic Disorder	1.6021000E-005	-
ENSG00000149177	Autistic Disorder	6.4663000E-006	-
ENSG00000149177	Autistic Disorder	1.0107000E-005	-
ENSG00000149177	Autistic Disorder	7.9038000E-006	-
ENSG00000149177	Autistic Disorder	2.4829000E-005	-
ENSG00000149177	3-hydroxy-1-methylpropylmercapturic acid	3E-6	26053186
ENSG00000149177	Smoking	3E-6	26053186
ENSG00000149177	Precursor Cell Lymphoblastic Leukemia-Lymphoma	1E-6	22076464
ENSG00000149177	Body Height	7E-12	23563607
ENSG00000149177	Body Height	4E-12	20881960
ENSG00000149177	Precursor Cell Lymphoblastic Leukemia-Lymphoma	5E-7	22076464
ENSG00000149177	Thrombin	6E-11	24357727

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000149177	rs4752805	11	47996803	A	Intraocular pressure	29617998	[0.12-0.18] unit decrease	0.152	EFO_0004695
ENSG00000149177	rs10838801	11	48076728	A	Height	20881960	[NR] unit decrease	0.027	EFO_0004339
ENSG00000149177	rs3942852	11	48093537	C	Acute lymphoblastic leukemia (childhood)	22076464			EFO_0000220
ENSG00000149177	rs3942852	11	48093537	T	Acute lymphoblastic leukemia (childhood)	22076464	[1.12-1.47]	1.2987013	EFO_0000220
ENSG00000149177	rs10838809	11	48152460	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit increase	0.3947	EFO_0004318\|EFO_0007015
ENSG00000149177	rs10838798	11	48069751	T	Height	23563607	[NR]	1.16	EFO_0004339
ENSG00000149177	rs138315285	11	48042642	A	Thrombin generation potential phenotypes	24357727	[25.11-46.51] nM increase	35.81	EFO_0005538
ENSG00000149177	rs7123436	11	47991932	?	Intraocular pressure	30054594	[0.13-0.19] unit increase	0.1574	EFO_0004695
ENSG00000149177	rs72899741	11	48057294	?	General cognitive ability	29844566	z-score decrease	4.661	EFO_0004337
ENSG00000149177	rs12574500	11	48126898	A	Blood protein levels	30072576	[0.12-0.28] unit decrease	0.199	EFO_0007937
ENSG00000149177	rs7123436	11	47991932	G	Intraocular pressure	29785010	[0.14-0.2] unit decrease	0.172	EFO_0004695
ENSG00000149177	rs7117516	11	48076944	?	Heel bone mineral density	30048462	[0.016-0.027] unit decrease	0.0215687	EFO_0009270
ENSG00000149177	rs7117516	11	48076944	T	Heel bone mineral density	30598549	[0.013-0.024] unit decrease	0.0185212	EFO_0009270
ENSG00000149177	rs185393137	11	48071804	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000149177	rs7117516	11	48076944	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000149177	rs11602180	11	48140901	C	Sleep duration	30846698	unit increase	0.918	EFO_0005271

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149177's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001772	immunological synapse	12913111.	IDA	Component
GO:0004725	protein tyrosine phosphatase activity	9531590.10821867.12913111.18348712.18936167.19332538.	IDA	Function
GO:0004725	protein tyrosine phosphatase activity	9780142.12475979.	IMP	Function
GO:0004725	protein tyrosine phosphatase activity	-	TAS	Function
GO:0005161	platelet-derived growth factor receptor binding	10821867.	IPI	Function
GO:0005515	protein binding	10821867.12370829.12475979.12771128.16893970.18936167.19167335.19494114.23650535.	IPI	Function
GO:0005886	plasma membrane	9531590.18348712.19836242.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005887	integral component of plasma membrane	7937872.	TAS	Component
GO:0005911	cell-cell junction	12370829.19332538.	IDA	Component
GO:0008013	beta-catenin binding	12370829.	IPI	Function
GO:0008285	negative regulation of cell proliferation	14709717.16682945.	IDA	Process
GO:0009986	cell surface	12913111.	IDA	Component
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	14709717.	IDA	Process
GO:0016791	phosphatase activity	12062403.12370829.19494114.	IDA	Function
GO:0016791	phosphatase activity	11259588.19836242.	IMP	Function
GO:0019901	protein kinase binding	19332538.	IPI	Function
GO:0030155	regulation of cell adhesion	12370829.	IMP	Process
GO:0030183	B cell differentiation	-	ISS	Process
GO:0030308	negative regulation of cell growth	14709717.	IDA	Process
GO:0030336	negative regulation of cell migration	16682945.	IDA	Process
GO:0032587	ruffle membrane	-	IEA	Component
GO:0032760	positive regulation of tumor necrosis factor production	-	ISS	Process
GO:0035335	peptidyl-tyrosine dephosphorylation	9531590.10821867.12913111.18348712.18936167.19332538.	IDA	Process
GO:0035335	peptidyl-tyrosine dephosphorylation	9780142.12475979.	IMP	Process
GO:0035579	specific granule membrane	-	TAS	Component
GO:0035584	calcium-mediated signaling using intracellular calcium source	-	ISS	Process
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	19836242.	IMP	Process
GO:0043116	negative regulation of vascular permeability	19332538.	IDA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043407	negative regulation of MAP kinase activity	19494114.	IDA	Process
GO:0043410	positive regulation of MAPK cascade	-	ISS	Process
GO:0045295	gamma-catenin binding	12370829.	IPI	Function
GO:0045785	positive regulation of cell adhesion	21091576.	IMP	Process
GO:0048008	platelet-derived growth factor receptor signaling pathway	21091576.	IMP	Process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	ISS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0050860	negative regulation of T cell receptor signaling pathway	12913111.	IDA	Process
GO:0050860	negative regulation of T cell receptor signaling pathway	9780142.11259588.	IMP	Process
GO:0050918	positive chemotaxis	14709717.	IDA	Process
GO:0051019	mitogen-activated protein kinase binding	19494114.	IPI	Function
GO:0051894	positive regulation of focal adhesion assembly	21091576.	IMP	Process
GO:0051897	positive regulation of protein kinase B signaling	18936167.	IMP	Process
GO:0051898	negative regulation of protein kinase B signaling	19922411.	IMP	Process
GO:0060242	contact inhibition	7937872.	NAS	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0070097	delta-catenin binding	12370829.19332538.	IPI	Function
GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	-	ISS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.