EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29269732Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.Nat Commun2017 Dec 21Cifdaloz Mdoi: 10.1038/s41467-017-02353-y.
23324604Overexpression of RNA-binding protein CELF1 prevents apoptosis and destabilizes pro-apoptotic mRNAs in oral cancer cells.RNA Biol2013 FebTalwar Sdoi: 10.4161/rna.23315
28535186FXR-Gankyrin axis is involved in development of pediatric liver cancer.Carcinogenesis2017 Jul 1Valanejad Ldoi: 10.1093/carcin/bgx050.
22646166The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability.Biochem J2012 Aug 15Chang ETdoi: 10.1042/BJ20120112.
24818870Lentivirus-mediated knockdown of CUGBP1 suppresses gastric cancer cell proliferation in vitro.Appl Biochem Biotechnol2014 JulWang Xdoi: 10.1007/s12010-014-0937-8
26498364RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma.Oncotarget2015 Dec 22House RPdoi: 10.18632/oncotarget.6204.
23359188CUG-binding protein 1 (CUGBP1) expression and prognosis of non-small cell lung cancer.Clin Transl Oncol2013 OctJiao Wdoi: 10.1007/s12094-013-1005-5
26234674Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1.Oncogene2016 Apr 21Phatak Pdoi: 10.1038/onc.2015.271

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1147484402Missense_MutationnovelD144E0.26
BLCAchr1147473222Missense_MutationnovelG400E0.09
BLCAchr1147488917Missense_Mutationrs748751583R33Q0.39RRM_1
BLCAchr1147472251SilentNAK480K0.06
BLCAchr1147477427Splice_SitenovelX255_splice0.22
BLCAchr1147488846Nonsense_MutationNAQ57*0.46
BRCAchr1147484483Missense_MutationNAK117N0.3
BRCAchr1147477421SilentNAL256L0.11
BRCAchr1147478934Nonsense_MutationnovelQ236*0.07
BRCAchr1147476858Missense_MutationnovelG331S0.11
BRCAchr1147471974Intronnovel0.36
BRCAchr1147476955Splice_RegionNAG298G0.12
BRCAchr1147473178Nonsense_MutationNAQ415*0.18
CESCchr1147488907SilentNAF36F0.56
CESCchr11474686513'UTRrs5437685950.12
CESCchr1147472300Missense_MutationnovelG464D0.31
CESCchr1147472341SilentnovelD450D0.37
CHOLchr11474686923'UTRnovel0.32
COADchr11474722283'UTRrs7607693050.07
COADchr1147484406Missense_MutationnovelP143H0.36
COADchr1147476875Missense_MutationNAT325M0.08
COADchr11474722283'UTRrs7607693050.43
COADchr1147472232Nonstop_Mutationnovel*487Rext*90.13
COADchr1147483496Missense_MutationNAA161V0.39
COADchr1147473194SilentNAP409P0.42
ESCAchr1147475419Missense_MutationnovelY369C0.43
GBMchr1147472081Intronnovel0.12
GBMchr1147488988SilentnovelD9D0.07
HNSCchr1147473226Missense_MutationnovelE399K0.24
HNSCchr11474890185'Flanknovel0.1
HNSCchr1147482715Missense_MutationnovelL223I0.26
HNSCchr1147488945Missense_MutationnovelP24S0.24RRM_1
KIRPchr1147473185Missense_MutationnovelF412L0.5
KIRPchr1147477397Frame_Shift_InsnovelL264Ffs*90.33
LAMLchr1147488896Missense_MutationnovelG40V0.04RRM_1
LAMLchr1147475347Missense_MutationnovelS393N0.23
LAMLchr1147484512Missense_MutationnovelR108G0.07
LGGchr1147476950Missense_MutationnovelS300L0.43
LIHCchr1147482739Nonsense_MutationNAG215*0.44
LIHCchr1147488970SilentNAA15A0.21
LIHCchr1147484492Missense_MutationnovelM114I0.43
LUADchr1147477387Missense_MutationnovelA268S0.22
LUADchr1147484464Missense_MutationNAI124V0.36
LUADchr1147488907Missense_MutationNAF36L0.08RRM_1
LUADchr1147472237Missense_MutationNAP485L0.15
LUSCchr1147488869Missense_MutationNAR49T0.14RRM_1
LUSCchr1147487234Missense_MutationnovelC62W0.56
LUSCchr1147475446Missense_MutationNAT360S0.18
LUSCchr1147482739Missense_MutationnovelG215R0.15
LUSCchr1147473155Missense_MutationnovelM422I0.3
LUSCchr1147475400SilentnovelP375P0.17
OVchr1147486771Missense_MutationNAA97P0.31
OVchr1147472041Intronnovel0.18
OVchr1147475467Missense_MutationNAG353E0.2
OVchr1147478879Missense_MutationNAG254V0.13
SARCchr11474684213'UTRnovel0.34
SARCchr11474684973'UTRnovel0.44
SKCMchr1147475452Missense_MutationNAA358V0.2
SKCMchr1147475369Nonsense_MutationNAQ386*0.3
SKCMchr1147473152SilentnovelP423P0.49
SKCMchr1147476903Missense_MutationNAG316R0.33
SKCMchr1147483501SilentNAA159A0.65
STADchr1147482755Silentrs749093088S209S0.44
STADchr1147471974Intronnovel0.64
STADchr1147482777Missense_MutationnovelQ202R0.23
STADchr1147477337SilentNAL284L0.23
STADchr1147473192Frame_Shift_InsnovelQ410Pfs*50.24
STADchr1147482723Missense_MutationNAL220R0.08
STADchr1147472301Missense_Mutationrs774921038G464S0.29
STADchr1147486769SilentnovelA97A0.32
STADchr1147488896Frame_Shift_DelnovelY39Lfs*90.36RRM_1
STADchr11474722273'UTRrs3761185780.23
STADchr1147488895SilentnovelG40G0.19
UCECchr1147473140Silentrs570022499V427V0.38
UCECchr1147477341Missense_Mutationrs757577626A283V0.32
UCECchr1147484413Missense_MutationnovelR141W0.23
UCECchr1147484452Missense_Mutationrs768296414F128L0.39
UCECchr11474687663'UTRnovel0.3
UCECchr1147472255Missense_Mutationrs763563976S479L0.44
UCECchr1147478902SilentnovelT246T0.27
UCECchr1147484460Missense_Mutationrs776176922R125Q0.1
UCECchr1147488907SilentNAF36F0.19
UCECchr1147472189Splice_Sitenovel0.36
UCECchr11474686923'UTRnovel0.26
UCECchr11474686113'UTRnovel0.57
UCECchr1147487182Missense_MutationNAH80N0.45
UCECchr1147472269SilentnovelV474V0.33
UCECchr1147489008Missense_MutationnovelG3S0.46
UCECchr1147477320Missense_MutationNAP290L0.31
UCECchr1147488981Missense_MutationnovelD12Y0.44
UCECchr1147488908Missense_MutationnovelF36Y0.6RRM_1
UCECchr11474995525'UTRnovel0.5
UCECchr11474686113'UTRnovel0.38
UCECchr1147477404Missense_MutationnovelQ262R0.43
UCECchr1147484428Nonsense_MutationnovelE136*0.42
UCECchr11474688443'UTRnovel0.29
UCECchr11474686033'UTRnovel0.33
UCECchr1147475356Missense_MutationNAA390V0.21
UCECchr1147473091Missense_MutationnovelF444V0.24
UCECchr1147477318Missense_MutationnovelL291I0.22
UCECchr1147478899SilentnovelL247L0.25
UCECchr11474685113'UTRnovel0.5
UCECchr11474688523'UTRNA0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.15220.018342
PRADDEL0.05890.0050014
TGCTDEL0.61330.21504

Survival Analysis
CancerP-value Q-value
STAD0.044

Kaplan-Meier Survival Analysis

ACC0.00039

Kaplan-Meier Survival Analysis

UCS0.05

Kaplan-Meier Survival Analysis

PRAD0.046

Kaplan-Meier Survival Analysis

COAD0.028

Kaplan-Meier Survival Analysis

PCPG0.018

Kaplan-Meier Survival Analysis

KICH0.025

Kaplan-Meier Survival Analysis

LIHC0.0084

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000149187 (Gene tree)
Gene ID
10658
Gene Symbol
CELF1
Alias
CUG-BP|hNab50|BRUNOL2|NAB50|CUGBP|NAPOR|EDEN-BP|CUGBP1
Full Name
CUGBP Elav-like family member 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
99,637 bases
Position
chr11:47,465,933-47,565,569
Accession
2549
RBP type
canonical RBP
Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000308386RRM_1PF00076.227.7e-5213
ENSP00000308386RRM_1PF00076.227.7e-5223
ENSP00000308386RRM_1PF00076.227.7e-5233
ENSP00000354639RRM_1PF00076.227.7e-5213
ENSP00000354639RRM_1PF00076.227.7e-5223
ENSP00000354639RRM_1PF00076.227.7e-5233
ENSP00000378706RRM_1PF00076.227.7e-5213
ENSP00000378706RRM_1PF00076.227.7e-5223
ENSP00000378706RRM_1PF00076.227.7e-5233
ENSP00000378705RRM_1PF00076.227.9e-5213
ENSP00000378705RRM_1PF00076.227.9e-5223
ENSP00000378705RRM_1PF00076.227.9e-5233
ENSP00000351409RRM_1PF00076.227.9e-5213
ENSP00000351409RRM_1PF00076.227.9e-5223
ENSP00000351409RRM_1PF00076.227.9e-5233
ENSP00000435926RRM_1PF00076.229.9e-5213
ENSP00000435926RRM_1PF00076.229.9e-5223
ENSP00000435926RRM_1PF00076.229.9e-5233
ENSP00000436864RRM_1PF00076.221e-5113
ENSP00000436864RRM_1PF00076.221e-5123
ENSP00000436864RRM_1PF00076.221e-5133
ENSP00000436191RRM_1PF00076.223.2e-1411
ENSP00000433986RRM_1PF00076.223.4e-1411
ENSP00000435320RRM_1PF00076.226.6e-1411
ENSP00000444825RRM_1PF00076.222.8e-1211
ENSP00000438044RRM_1PF00076.221.2e-1111
ENSP00000435423RRM_1PF00076.221.7e-0611
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21233287Characterization of MRP RNA-protein interactions within the perinucleolar compartment.Mol Biol Cell2011 Mar 15Pollock Cdoi: 10.1091/mbc.E10-09-0768
27255754RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice.Diabetologia2016 SepZhai Kdoi: 10.1007/s00125-016-4005-5
29218006Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat.Front Aging Neurosci2017 Nov 23Smidak Rdoi: 10.3389/fnagi.2017.00384
30922080miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.FASEB J2019 JunSaul MJdoi: 10.1096/fj.201802547R
15961673Enhanced CCAAT/enhancer-binding protein beta-liver-enriched inhibitory protein production by Oltipraz, which accompanies CUG repeat-binding protein-1 (CUGBP1) RNA-binding protein activation, leads to inhibition of preadipocyte differentiation.Mol Pharmacol2005 SepBae EJ-
11564876Molecular basis for impaired muscle differentiation in myotonic dystrophy.Mol Cell Biol2001 OctTimchenko NA-
11158314The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.Mol Cell Biol2001 FebLadd AN-
16836486Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding.Biol Cell2006 NovCosson B-
19909263Pathogenic mechanisms of myotonic dystrophy.Biochem Soc Trans2009 DecLee JEdoi: 10.1042/BST0371281.
19590039Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients.Am J Pathol2009 AugSalisbury Edoi: 10.2353/ajpath.2009.090047
17936705Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.Mol Cell2007 Oct 12Kuyumcu-Martinez NM-
21889481RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2.Am J Pathol2011 NovJones Kdoi: 10.1016/j.ajpath.2011.07.013
20947010Repeat recognition.Structure2010 Oct 13Tripsianes Kdoi: 10.1016/j.str.2010.09.006.
28350193Reconstitution of HuR-Inhibited CUGBP1 Expression Protects Cardiomyocytes from Acute Myocardial Infarction-Induced Injury.Antioxid Redox Signal2017 Nov 10Gu Ldoi: 10.1089/ars.2016.6880
25003008GSK3β is a new therapeutic target for myotonic dystrophy type 1.Rare Dis2013 Sep 26Wei Cdoi: 10.4161/rdis.26555
23796888Molecular mechanisms of muscle atrophy in myotonic dystrophies.Int J Biochem Cell Biol2013 OctTimchenko Ldoi: 10.1016/j.biocel.2013.06.010
29203592Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.FASEB J2018 AprWei Cdoi: 10.1096/fj.201700700R
15226369Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events.J Cell Sci2004 Jul 15Ladd AN-
15099703Altered expression of CUG binding protein 1 mRNA in myotonic dystrophy 1: possible RNA-RNA interaction.Neurosci Res2004 MayWatanabe T-
22180311The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.Wiley Interdiscip Rev RNA2012 Jan-FebDasgupta Tdoi: 10.1002/wrna.107
16601207CUG-BP binds to RNA substrates and recruits PARN deadenylase.RNA2006 JunMoraes KC-
12409457An analysis of the sequence requirements of EDEN-BP for specific RNA binding.Nucleic Acids Res2002 Nov 1Bonnet-Corven S-
10866799A trans-acting factor, isolated by the three-hybrid system, that influences alternative splicing of the amyloid precursor protein minigene.Eur J Biochem2000 JulPoleev A-
19692580Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice.Dis Model Mech2009 Sep-OctYu Zdoi: 10.1242/dmm.003301
18559347The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy.J Biol Chem2008 Aug 15Zhang Ldoi: 10.1074/jbc.M802803200
20622515The role of CELF proteins in neurological disorders.RNA Biol2010 Jul-AugGallo JM-
24878509LDB3 splicing abnormalities are specific to skeletal muscles of patients with myotonic dystrophy type 1 and alter its PKC binding affinity.Neurobiol Dis2014 SepYamashita Ydoi: 10.1016/j.nbd.2014.05.026
24837674RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins.Mol Cell2014 Jun 5Lambert Ndoi: 10.1016/j.molcel.2014.04.016
24376746Overexpression of CUGBP1 in skeletal muscle from adult classic myotonic dystrophy type 1 but not from myotonic dystrophy type 2.PLoS One2013 Dec 20Cardani Rdoi: 10.1371/journal.pone.0083777
24001600Evaluating the effects of CELF1 deficiency in a mouse model of RNA toxicity.Hum Mol Genet2014 Jan 15Kim YKdoi: 10.1093/hmg/ddt419
23922231A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1.Hum Mol Genet2013 Dec 20Gauthier Mdoi: 10.1093/hmg/ddt373
23468433Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development.Dev Dyn2013 JunBlech-Hermoni Ydoi: 10.1002/dvdy.23959
25619475Overexpression of CUGBP1 is associated with the progression of non-small cell lung cancer.Tumour Biol2015 JunGao Cdoi: 10.1007/s13277-015-3103-1
26169831Hypogonadism Associated with Cyp19a1 (Aromatase) Posttranscriptional Upregulation in Celf1 Knockout Mice.Mol Cell Biol2015 SepBoulanger Gdoi: 10.1128/MCB.00074-15
29687899Myotonic Dystrophy and Developmental Regulation of RNA Processing.Compr Physiol2018 Mar 25Thomas JDdoi: 10.1002/cphy.c170002.
30997488MBNL1 overexpression is not sufficient to rescue the phenotypes in a mouse model of RNA toxicity.Hum Mol Genet2019 Jul 15Yadava RSdoi: 10.1093/hmg/ddz065.
16938098CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding.Biochem J2006 Dec 1Marquis J-
10854425Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein alpha mRNA.J Biol Chem2000 Sep 1Welm AL-
15082764Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells.Mol Cell Biol2004 MayBaldwin BR-
19933768A strategy to analyze the phenotypic consequences of inhibiting the association of an RNA-binding protein with a specific RNA.RNA2010 JanCibois Mdoi: 10.1261/rna.1742610
18039683Quantitative analysis of CUG-BP1 binding to RNA repeats.J Biochem2008 MarMori D-
22646166The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability.Biochem J2012 Aug 15Chang ETdoi: 10.1042/BJ20120112.
22117072Regulation of CUG-binding protein 1 (CUGBP1) binding to target transcripts upon T cell activation.J Biol Chem2012 Jan 6Beisang Ddoi: 10.1074/jbc.M111.291658
23155001Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function.Mol Biol Cell2013 JanYu TXdoi: 10.1091/mbc.E12-07-0531
23160194GSK3β mediates muscle pathology in myotonic dystrophy.J Clin Invest2012 DecJones Kdoi: 10.1172/JCI64081
20502647HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1.Curr Chem Genomics2010 Mar 19O'Leary DAdoi: 10.2174/1875397301004010009.
24740539Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1.Am J Physiol Cell Physiol2014 Jun 15Chung HKdoi: 10.1152/ajpcell.00093.2014
27512039miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification.Proc Natl Acad Sci U S A2016 Aug 23Shen Xdoi: 10.1073/pnas.1608256113
23564453Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.J Biol Chem2013 May 17Jin Jdoi: 10.1074/jbc.M113.460840
26491048CUGBP1 and HuR regulate E-cadherin translation by altering recruitment of E-cadherin mRNA to processing bodies and modulate epithelial barrier function.Am J Physiol Cell Physiol2016 Jan 1Yu TXdoi: 10.1152/ajpcell.00112.2015
26283512The Expression of CUGBP1 After Spinal Cord Injury in Rats.Neurochem Res2015 SepYang Ldoi: 10.1007/s11064-015-1692-0
25808495Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal.Mol Biol Cell2015 May 15Liu Ldoi: 10.1091/mbc.E14-11-1500
9887331Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy.Hum Mol Genet1999 JanLu X-
9427761EDEN and EDEN-BP, a cis element and an associated factor that mediate sequence-specific mRNA deadenylation in Xenopus embryos.EMBO J1998 Jan 2Paillard L-
10446244Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein.Nucleic Acids Res1999 Sep 1Michalowski S-
8948631Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.Nucleic Acids Res1996 Nov 15Timchenko LT-
16931514Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.J Biol Chem2006 Oct 27Timchenko LT-
12799066A functional deadenylation assay identifies human CUG-BP as a deadenylation factor.Biol Cell2003 Mar-AprPaillard L-
12242300Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins.Mol Cell Biol2002 OctTimchenko LT-
16418324Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells.Blood2006 May 15Guerzoni C-
11433021In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts.Nucleic Acids Res2001 Jul 1Fardaei M-
11032753The CUG-binding protein binds specifically to UG dinucleotide repeats in a yeast three-hybrid system.Biochem Biophys Res Commun2000 Oct 22Takahashi N-
10893231A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.J Biol Chem2000 Sep 15Good PJ-
10781958Vegetal localization of the maternal mRNA encoding an EDEN-BP/Bruno-like protein in zebrafish.Mech Dev2000 MaySuzuki H-
15788409RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2.J Biol Chem2005 May 27Timchenko NA-
15548579EDEN-BP-dependent post-transcriptional regulation of gene expression in Xenopus somitic segmentation.Development2004 DecGautier-Courteille C-
14722159Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats.Hum Mol Genet2004 Mar 1Kino Y-
14726956Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.EMBO J2004 Jan 28Iakova P-
20051426Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.Hum Mol Genet2010 Mar 15Koshelev Mdoi: 10.1093/hmg/ddp570
19854948The neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation.Nucleic Acids Res2010 JanBarron VAdoi: 10.1093/nar/gkp766
19720736MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.Nucleic Acids Res2009 OctKino Ydoi: 10.1093/nar/gkp681
23056285Inactivation of the Celf1 gene that encodes an RNA-binding protein delays the first wave of spermatogenesis in mice.PLoS One2012Cibois Mdoi: 10.1371/journal.pone.0046337
19106619Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.RNA Biol2009 Jan-MarBubenik JL-
18622015HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice.J Biol Chem2008 Sep 19Wang GLdoi: 10.1074/jbc.M803544200
18570922Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1.Exp Cell Res2008 Jul 1Salisbury Edoi: 10.1016/j.yexcr.2008.04.018
18267972Identification of CUG-BP1/EDEN-BP target mRNAs in Xenopus tropicalis.Nucleic Acids Res2008 AprGraindorge Adoi: 10.1093/nar/gkn031
18243108GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover.Mol Cell2008 Feb 1Kim HHdoi: 10.1016/j.molcel.2008.01.005.
18164289Dual localization of the RNA binding protein CUGBP-1 to stress granule and perinucleolar compartment.Exp Cell Res2008 Feb 1Fujimura Kdoi: 10.1016/j.yexcr.2007.10.024
18095176Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units.Chromosome Res2007Morgan GT-
18025168CUGBP1 is required for IFNbeta-mediated induction of dominant-negative CEBPbeta and suppression of SIV replication in macrophages.J Immunol2007 Dec 1Dudaronek JM-
22892678Superresolution imaging of transcription units on newt lampbrush chromosomes.Chromosome Res2012 DecKaufmann Rdoi: 10.1007/s10577-012-9306-z.
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17698010RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.Neuron2007 Aug 16Sofola OA-
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20631008CELF proteins regulate CFTR pre-mRNA splicing: essential role of the divergent domain of ETR-3.Nucleic Acids Res2010 NovDujardin Gdoi: 10.1093/nar/gkq573
20633547BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA.Dev Biol2010 Sep 15Horb LDdoi: 10.1016/j.ydbio.2010.07.005
20574513Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells.PLoS One2010 Jun 21Lee JEdoi: 10.1371/journal.pone.0011201.
20227387Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.Biochem Biophys Res Commun2010 Apr 16Le Tonqueze Odoi: 10.1016/j.bbrc.2010.03.020
24752171Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.Nat Commun2014 Apr 22Giudice Jdoi: 10.1038/ncomms4603.
26498364RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma.Oncotarget2015 Dec 22House RPdoi: 10.18632/oncotarget.6204.
24502807Suppression of CUGBP1 inhibits growth of hepatocellular carcinoma cells.Clin Invest Med2014 Feb 1Liu Y-
28129347The CELF1 RNA-Binding Protein Regulates Decay of Signal Recognition Particle mRNAs and Limits Secretion in Mouse Myoblasts.PLoS One2017 Jan 27Russo Jdoi: 10.1371/journal.pone.0170680
24237593Si-RNA mediated knockdown of CELF1 gene suppressed the proliferation of human lung cancer cells.Cancer Cell Int2013 Nov 15Wu LNdoi: 10.1186/1475-2867-13-115.
24151077Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.J Biol Chem2013 Dec 6Verma SKdoi: 10.1074/jbc.M113.507426
24167718A gene regulation network controlled by Celf1 protein-rbpj mRNA interaction in Xenopus somite segmentation.Biol Open2013 Aug 30Cibois Mdoi: 10.1242/bio.20135629
27657532Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.PLoS One2016 Sep 22Kim YKdoi: 10.1371/journal.pone.0163325
24005864Celf1 is required for formation of endoderm-derived organs in zebrafish.Int J Mol Sci2013 Sep 3Tahara Ndoi: 10.3390/ijms140918009.
23748565Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.Nucleic Acids Res2013 AugEdwards JMdoi: 10.1093/nar/gkt470
23536431Dysfunction of protein homeostasis in myotonic dystrophies.Histol Histopathol2013 SepMeola Gdoi: 10.14670/HH-28.1089
27222809Identification of CELF1 RNA targets by CLIP-seq in human HeLa cells.Genom Data2016 Apr 19Le Tonqueze Odoi: 10.1016/j.gdata.2016.04.009
27144987CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.Dev Dyn2016 AugBlech-Hermoni Ydoi: 10.1002/dvdy.24413
26866591Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle.PLoS One2016 Feb 11Blech-Hermoni Ydoi: 10.1371/journal.pone.0149061
26249002Altered CELF1 binding to target transcripts in malignant T cells.RNA2015 OctBohjanen PRdoi: 10.1261/rna.049940.115
26234674Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1.Oncogene2016 Apr 21Phatak Pdoi: 10.1038/onc.2015.271
25883322Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins.Genome Res2015 JunWang ETdoi: 10.1101/gr.184390.114
25887157Celf1 regulates cell cycle and is partially responsible for defective myoblast differentiation in myotonic dystrophy RNA toxicity.Biochim Biophys Acta2015 JulPeng Xdoi: 10.1016/j.bbadis.2015.04.010
28535186FXR-Gankyrin axis is involved in development of pediatric liver cancer.Carcinogenesis2017 Jul 1Valanejad Ldoi: 10.1093/carcin/bgx050.
28559429RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.Mol Cell Biol2017 Jul 28Lewis Kdoi: 10.1128/MCB.00128-17
28716948Cooperative Repression of Insulin-Like Growth Factor Type 2 Receptor Translation by MicroRNA 195 and RNA-Binding Protein CUGBP1.Mol Cell Biol2017 Sep 12Zhang Ydoi: 10.1128/MCB.00225-17
28874395CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy.Circ Res2017 Oct 27Chang KTdoi: 10.1161/CIRCRESAHA.117.311281
29269732Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.Nat Commun2017 Dec 21Cifdaloz Mdoi: 10.1038/s41467-017-02353-y.
29565969The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development.PLoS Genet2018 Mar 22Siddam ADdoi: 10.1371/journal.pgen.1007278
29610944Imaging the dynamics of transcription loops in living chromosomes.Chromosoma2018 SepMorgan GTdoi: 10.1007/s00412-018-0667-8
29716962Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1.Dis Model Mech2018 May 21Picchio Ldoi: 10.1242/dmm.031849.
30234379Identify Cross Talk Between Circadian Rhythm and Coronary Heart Disease by Multiple Correlation Analysis.J Comput Biol2018 DecYan Xdoi: 10.1089/cmb.2017.0254
30508596A positive feedback regulation of Heme oxygenase 1 by CELF1 in cardiac myoblast cells.Biochim Biophys Acta Gene Regul Mech2019 FebLiu Ydoi: 10.1016/j.bbagrm.2018.11.006
17241108Translational control of maskin mRNA by its 3' untranslated region.Biol Cell2007 MayMeijer HA-
9563950Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy.Science1998 May 1Philips AV-
9371827Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice.Proc Natl Acad Sci U S A1997 Nov 25Roberts R-
8789448Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy.Hum Mol Genet1996 JanTimchenko LT-
12746489Regulation of EDEN-dependent deadenylation of Aurora A/Eg2-derived mRNA via phosphorylation and dephosphorylation in Xenopus laevis egg extracts.J Cell Sci2003 Jul 1Detivaud L-
11124939RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1.J Biol Chem2001 Mar 16Timchenko NA-
14722059Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis.J Biol Chem2004 Mar 26Timchenko NA-
19047369SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing.Mol Cell Biol2009 FebSen Sdoi: 10.1128/MCB.01709-08
18042543The regulatory element in the 3'-untranslated region of human papillomavirus 16 inhibits expression by binding CUG-binding protein 1.J Biol Chem2008 Jan 25Goraczniak R-
20603324CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1.Hum Mol Genet2010 Sep 15Ward AJdoi: 10.1093/hmg/ddq277
25123787Alternative polyadenylation regulates CELF1/CUGBP1 target transcripts following T cell activation.Gene2014 Oct 15Beisang Ddoi: 10.1016/j.gene.2014.08.021
25077823Knockdown of CUG-binding protein 1 induces apoptosis of human laryngeal cancer cells.Cell Biol Int2014 DecZhou Ydoi: 10.1002/cbin.10356
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Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000524648CELF1-207393--- (aa)--
ENST00000525841CELF1-208622-ENSP0000043619187 (aa)-E9PQK4
ENST00000535982CELF1-218549-ENSP00000438044103 (aa)-F5H0D8
ENST00000534614CELF1-217567--- (aa)--
ENST00000539254CELF1-219572--- (aa)--
ENST00000539455CELF1-220800--- (aa)--
ENST00000310513CELF1-2014583XM_017017135ENSP00000308386482 (aa)XP_016872624Q92879
ENST00000528538CELF1-212581-ENSP0000044241514 (aa)-F5H7M7
ENST00000530151CELF1-213583-ENSP0000043398695 (aa)-E9PSH0
ENST00000358597CELF1-2022108XM_011519854ENSP00000351409486 (aa)XP_011518156Q92879
ENST00000422993CELF1-206553--- (aa)--
ENST00000543178CELF1-221576-ENSP0000044482578 (aa)-F5H4Y5
ENST00000395290CELF1-2047666-ENSP00000378705485 (aa)-Q92879
ENST00000361904CELF1-2031580-ENSP00000354639483 (aa)-Q92879
ENST00000395292CELF1-2052191XM_011519859ENSP00000378706483 (aa)XP_011518161Q92879
ENST00000532048CELF1-2153044XM_011519850ENSP00000435926512 (aa)XP_011518152Q92879
ENST00000526419CELF1-210476-ENSP0000043542356 (aa)-E9PKA1
ENST00000526277CELF1-209556-ENSP0000043886237 (aa)-F5H3J7
ENST00000531165CELF1-2143650XM_011519852ENSP00000436864514 (aa)XP_011518154G5EA30
ENST00000532146CELF1-216473--- (aa)--
ENST00000528434CELF1-211543-ENSP00000435320114 (aa)-E9PKU1
Gene Model
Click here to download ENSG00000149187's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000149187Erythrocyte Count3.0930000E-006-
ENSG00000149187Hypertension1.0046244E-006-
ENSG00000149187Hypertension3.6042817E-007-
ENSG00000149187Alzheimer Disease1E-824162737
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000149187rs108387251147536319CAlzheimer's disease (late onset)24162737[1.05-1.11]1.08EFO_0000249
ENSG00000149187rs618951101147535608ATotal body bone mineral density29304378unit increase0.0643EFO_0003923
ENSG00000149187rs110392971147559891?Glomerular filtration rate29403010[0.019-0.037] unit decrease novel0.02801EFO_0005208
ENSG00000149187rs108387251147536319?Alzheimer's disease or family history of Alzheimer's disease29777097[1.02288186365195- 1.05588153898494]1.0392507EFO_0000249|EFO_0009268
ENSG00000149187rs28689961147553818TImmature fraction of reticulocytes27863252[0.015-0.029] unit increase0.02202999EFO_0007986
ENSG00000149187rs71246811147508395ABody mass index in physically active individuals28448500[0.015-0.031] kg/m2 increase0.0227EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index28448500[0.017-0.032] kg/m2 increase0.0245EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index28448500[0.017-0.039] kg/m2 increase0.028EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index28448500[0.019-0.034] kg/m2 increase0.0262EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index28448500[0.014-0.034] kg/m2 increase0.024EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index28448500[0.015-0.035] kg/m2 increase0.025EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index28448500[0.014-0.033] kg/m2 increase0.0235EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index in physically active individuals28448500[0.016-0.033] kg/m2 increase0.0247EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000149187rs71246811147508395ABody mass index26426971unit increase0.024504084EFO_0004340
ENSG00000149187rs122250511147550415THand grip strength29691431[0.0022-0.0038] unit increase0.003EFO_0006941
ENSG00000149187rs110392661147510843THand grip strength29691431[0.0024-0.0036] unit decrease0.003EFO_0006941
ENSG00000149187rs71246811147508395CBody mass index30108127[NR] unit decrease0.023EFO_0004340
ENSG00000149187rs110392661147510843?Menarche (age at onset)30595370EFO_0004703
ENSG00000149187rs71246811147508395?Body mass index30595370EFO_0004340
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149187's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000149187CELF18931.169ENSG00000242389RBMY1E7931.169
ENSG00000149187CELF17635.593ENSG00000213516RBMXL15132.500
ENSG00000149187CELF17633.333ENSG00000147274RBMX8833.333
ENSG00000149187CELF16036.047ENSG00000070756PABPC15635.526
ENSG00000149187CELF18335.385ENSG00000099622CIRBP9031.944
ENSG00000149187CELF15132.787ENSG00000131051RBM397330.000
ENSG00000149187CELF19332.955ENSG00000107105ELAVL29032.692
ENSG00000149187CELF19252.055ENSG00000161082CELF56761.268
ENSG00000149187CELF19744.512ENSG00000159409CELF38955.191
ENSG00000149187CELF110050.495ENSG00000101489CELF410061.194
ENSG00000149187CELF18931.169ENSG00000242875RBMY1B7931.169
ENSG00000149187CELF18837.681ENSG00000132819RBM385537.681
ENSG00000149187CELF110088.462ENSG00000048740CELF210080.041
ENSG00000149187CELF15340.789ENSG00000153250RBMS16040.789
ENSG00000149187CELF19432.584ENSG00000196361ELAVL37342.391
ENSG00000149187CELF18931.169ENSG00000234414RBMY1A17931.169
ENSG00000149187CELF15039.474ENSG00000076067RBMS25939.474
ENSG00000149187CELF16636.232ENSG00000101104PABPC1L6436.232
ENSG00000149187CELF19431.461ENSG00000162374ELAVL47640.741
ENSG00000149187CELF17939.130ENSG00000152430BOLL8032.857
ENSG00000149187CELF16938.889ENSG00000135486HNRNPA19534.862
ENSG00000149187CELF15443.421ENSG00000144642RBMS36743.421
ENSG00000149187CELF17933.333ENSG00000173933RBM47730.952
ENSG00000149187CELF18232.394ENSG00000151962RBM465631.169
ENSG00000149187CELF17933.333ENSG00000173914RBM4B7730.952
ENSG00000149187CELF19131.461ENSG00000066044ELAVL18345.679
ENSG00000149187CELF17138.889ENSG00000090621PABPC46238.889
ENSG00000149187CELF110051.546ENSG00000140488CELF67753.801
ENSG00000149187CELF18334.586ENSG00000254535PABPC4L5034.722
ENSG00000149187CELF18931.169ENSG00000244395RBMY1D7931.169
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000149187CELF110089.189ENSAPOG00000024000celf110085.193Acanthochromis_polyacanthus
ENSG00000149187CELF1100100.000ENSAMEG00000007596CELF110099.222Ailuropoda_melanoleuca
ENSG00000149187CELF110088.421ENSACIG00000023843celf110082.438Amphilophus_citrinellus
ENSG00000149187CELF110089.189ENSAOCG00000001252celf110085.193Amphiprion_ocellaris
ENSG00000149187CELF110088.421ENSAPEG00000002340celf110085.462Amphiprion_percula
ENSG00000149187CELF110087.368ENSATEG00000010871celf110082.816Anabas_testudineus
ENSG00000149187CELF110097.436ENSACAG00000002114CELF110094.932Anolis_carolinensis
ENSG00000149187CELF1100100.000ENSANAG00000031770CELF110099.805Aotus_nancymaae
ENSG00000149187CELF110089.189ENSACLG00000010181-10085.049Astatotilapia_calliptera
ENSG00000149187CELF110089.474ENSAMXG00000020576celf19681.071Astyanax_mexicanus
ENSG00000149187CELF1100100.000ENSBTAG00000002520CELF110098.765Bos_taurus
ENSG00000149187CELF1100100.000ENSCJAG00000020133CELF1100100.000Callithrix_jacchus
ENSG00000149187CELF1100100.000ENSCAFG00000008452CELF110099.416Canis_familiaris
ENSG00000149187CELF1100100.000ENSCAFG00020025487CELF110099.416Canis_lupus_dingo
ENSG00000149187CELF1100100.000ENSCHIG00000024582CELF110098.833Capra_hircus
ENSG00000149187CELF1100100.000ENSTSYG00000003866CELF1100100.000Carlito_syrichta
ENSG00000149187CELF19973.125ENSCAPG00000006787CELF110071.401Cavia_aperea
ENSG00000149187CELF1100100.000ENSCPOG00000036381CELF110099.795Cavia_porcellus
ENSG00000149187CELF1100100.000ENSCCAG00000033487CELF1100100.000Cebus_capucinus
ENSG00000149187CELF1100100.000ENSCATG00000040143CELF1100100.000Cercocebus_atys
ENSG00000149187CELF1100100.000ENSCLAG00000011791CELF110099.611Chinchilla_lanigera
ENSG00000149187CELF1100100.000ENSCSAG00000005786CELF110099.611Chlorocebus_sabaeus
ENSG00000149187CELF1100100.000ENSCHOG00000004196-68100.000Choloepus_hoffmanni
ENSG00000149187CELF110097.436ENSCPBG00000022914CELF110096.728Chrysemys_picta_bellii
ENSG00000149187CELF1100100.000ENSCANG00000032689CELF1100100.000Colobus_angolensis_palliatus
ENSG00000149187CELF1100100.000ENSCGRG00001011274Celf110099.222Cricetulus_griseus_chok1gshd
ENSG00000149187CELF1100100.000ENSCGRG00000015357Celf110099.222Cricetulus_griseus_crigri
ENSG00000149187CELF110088.421ENSCSEG00000008675celf110074.948Cynoglossus_semilaevis
ENSG00000149187CELF110078.571ENSCVAG00000002834-9178.333Cyprinodon_variegatus
ENSG00000149187CELF110089.474ENSDARG00000005315celf110088.757Danio_rerio
ENSG00000149187CELF1100100.000ENSDNOG00000009523CELF1100100.000Dasypus_novemcinctus
ENSG00000149187CELF1100100.000ENSDORG00000013721Celf110088.716Dipodomys_ordii
ENSG00000149187CELF173100.000ENSETEG00000004507CELF183100.000Echinops_telfairi
ENSG00000149187CELF1100100.000ENSEASG00005010831CELF110092.218Equus_asinus_asinus
ENSG00000149187CELF1100100.000ENSECAG00000007741CELF110099.585Equus_caballus
ENSG00000149187CELF1100100.000ENSEEUG00000009782CELF110081.276Erinaceus_europaeus
ENSG00000149187CELF110087.368ENSELUG00000023173celf110084.886Esox_lucius
ENSG00000149187CELF1100100.000ENSFCAG00000002535CELF110099.588Felis_catus
ENSG00000149187CELF110097.436ENSFALG00000006402CELF110095.543Ficedula_albicollis
ENSG00000149187CELF1100100.000ENSFDAG00000008517CELF110099.589Fukomys_damarensis
ENSG00000149187CELF110083.929ENSFHEG00000021226-8067.045Fundulus_heteroclitus
ENSG00000149187CELF110087.368ENSGMOG00000012783celf19884.156Gadus_morhua
ENSG00000149187CELF110097.436ENSGALG00000008097CELF110096.701Gallus_gallus
ENSG00000149187CELF110082.143ENSGAFG00000017082-7672.727Gambusia_affinis
ENSG00000149187CELF110088.421ENSGACG00000014226celf19578.656Gasterosteus_aculeatus
ENSG00000149187CELF110097.436ENSGAGG00000011562CELF110096.694Gopherus_agassizii
ENSG00000149187CELF1100100.000ENSGGOG00000004106CELF1100100.000Gorilla_gorilla
ENSG00000149187CELF110089.189ENSHBUG00000017881celf110085.049Haplochromis_burtoni
ENSG00000149187CELF110098.214ENSHGLG00000019214-10091.925Heterocephalus_glaber_female
ENSG00000149187CELF1100100.000ENSHGLG00000006909-10099.795Heterocephalus_glaber_female
ENSG00000149187CELF1100100.000ENSHGLG00100017423-10095.238Heterocephalus_glaber_male
ENSG00000149187CELF1100100.000ENSHGLG00100013863-10099.795Heterocephalus_glaber_male
ENSG00000149187CELF110088.421ENSHCOG00000000258celf110084.836Hippocampus_comes
ENSG00000149187CELF110089.474ENSIPUG00000023708celf110083.234Ictalurus_punctatus
ENSG00000149187CELF1100100.000ENSSTOG00000000613CELF1100100.000Ictidomys_tridecemlineatus
ENSG00000149187CELF1100100.000ENSJJAG00000020280Celf110099.416Jaculus_jaculus
ENSG00000149187CELF110082.143ENSKMAG00000008670-6683.607Kryptolebias_marmoratus
ENSG00000149187CELF110087.368ENSLBEG00000018296celf19385.425Labrus_bergylta
ENSG00000149187CELF17085.546ENSLBEG00000002047-9883.776Labrus_bergylta
ENSG00000149187CELF110094.595ENSLACG00000018990CELF19281.522Latimeria_chalumnae
ENSG00000149187CELF110093.684ENSLOCG00000005966celf19488.153Lepisosteus_oculatus
ENSG00000149187CELF1100100.000ENSLAFG00000003484CELF110099.027Loxodonta_africana
ENSG00000149187CELF1100100.000ENSMFAG00000003505CELF1100100.000Macaca_fascicularis
ENSG00000149187CELF1100100.000ENSMMUG00000011657CELF1100100.000Macaca_mulatta
ENSG00000149187CELF1100100.000ENSMNEG00000022558CELF1100100.000Macaca_nemestrina
ENSG00000149187CELF1100100.000ENSMLEG00000040834CELF1100100.000Mandrillus_leucophaeus
ENSG00000149187CELF110089.474ENSMAMG00000010052celf110083.058Mastacembelus_armatus
ENSG00000149187CELF110089.189ENSMZEG00005018307celf110085.049Maylandia_zebra
ENSG00000149187CELF110097.436ENSMGAG00000010629CELF19696.502Meleagris_gallopavo
ENSG00000149187CELF1100100.000ENSMAUG00000009468Celf110099.384Mesocricetus_auratus
ENSG00000149187CELF1100100.000ENSMICG00000045113CELF1100100.000Microcebus_murinus
ENSG00000149187CELF1100100.000ENSMOCG00000012633Celf110099.589Microtus_ochrogaster
ENSG00000149187CELF110087.368ENSMMOG00000015460celf19583.471Mola_mola
ENSG00000149187CELF110098.354ENSMODG00000019913CELF110098.354Monodelphis_domestica
ENSG00000149187CELF1100100.000MGP_CAROLIEiJ_G0023949Celf110099.589Mus_caroli
ENSG00000149187CELF1100100.000ENSMUSG00000005506Celf110099.589Mus_musculus
ENSG00000149187CELF1100100.000MGP_PahariEiJ_G0025385Celf110099.589Mus_pahari
ENSG00000149187CELF1100100.000MGP_SPRETEiJ_G0024859Celf110099.384Mus_spretus
ENSG00000149187CELF1100100.000ENSMPUG00000003960CELF19399.416Mustela_putorius_furo
ENSG00000149187CELF1100100.000ENSMLUG00000016631CELF110098.839Myotis_lucifugus
ENSG00000149187CELF1100100.000ENSNGAG00000017390Celf110097.860Nannospalax_galili
ENSG00000149187CELF19955.809ENSNBRG00000023547-8555.602Neolamprologus_brichardi
ENSG00000149187CELF1100100.000ENSNLEG00000014638CELF1100100.000Nomascus_leucogenys
ENSG00000149187CELF110098.718ENSMEUG00000007763CELF110098.148Notamacropus_eugenii
ENSG00000149187CELF1100100.000ENSOPRG00000003239-10099.177Ochotona_princeps
ENSG00000149187CELF1100100.000ENSODEG00000015204CELF110099.611Octodon_degus
ENSG00000149187CELF110089.189ENSONIG00000008300celf110084.302Oreochromis_niloticus
ENSG00000149187CELF110098.947ENSOANG00000007896CELF19997.860Ornithorhynchus_anatinus
ENSG00000149187CELF1100100.000ENSOCUG00000001311CELF110099.222Oryctolagus_cuniculus
ENSG00000149187CELF110085.263ENSOMEG00000002381celf110079.794Oryzias_melastigma
ENSG00000149187CELF1100100.000ENSOGAG00000011600CELF110099.033Otolemur_garnettii
ENSG00000149187CELF1100100.000ENSOARG00000006924CELF110098.971Ovis_aries
ENSG00000149187CELF1100100.000ENSPPAG00000033870CELF1100100.000Pan_paniscus
ENSG00000149187CELF1100100.000ENSPPRG00000002376CELF110099.609Panthera_pardus
ENSG00000149187CELF1100100.000ENSPTIG00000003974CELF110099.609Panthera_tigris_altaica
ENSG00000149187CELF1100100.000ENSPTRG00000052299CELF1100100.000Pan_troglodytes
ENSG00000149187CELF1100100.000ENSPANG00000021676CELF1100100.000Papio_anubis
ENSG00000149187CELF110089.474ENSPKIG00000012324celf110088.430Paramormyrops_kingsleyae
ENSG00000149187CELF110096.154ENSPSIG00000003922CELF110094.380Pelodiscus_sinensis
ENSG00000149187CELF110088.421ENSPMGG00000013192celf19676.735Periophthalmus_magnuspinnatus
ENSG00000149187CELF1100100.000ENSPEMG00000015644Celf110099.589Peromyscus_maniculatus_bairdii
ENSG00000149187CELF110098.718ENSPCIG00000022947CELF110098.012Phascolarctos_cinereus
ENSG00000149187CELF17070.118ENSPFOG00000000961-10068.563Poecilia_formosa
ENSG00000149187CELF110083.929ENSPFOG00000007187-8382.022Poecilia_formosa
ENSG00000149187CELF110083.929ENSPLAG00000002915-7259.375Poecilia_latipinna
ENSG00000149187CELF18870.468ENSPLAG00000019373-8866.760Poecilia_latipinna
ENSG00000149187CELF110083.929ENSPMEG00000005661-7785.000Poecilia_mexicana
ENSG00000149187CELF110084.615ENSPREG00000022185-10072.266Poecilia_reticulata
ENSG00000149187CELF1100100.000ENSPPYG00000003302CELF110098.835Pongo_abelii
ENSG00000149187CELF1100100.000ENSPCAG00000002631CELF110097.942Procavia_capensis
ENSG00000149187CELF1100100.000ENSPCOG00000021865CELF110095.525Propithecus_coquereli
ENSG00000149187CELF19799.531ENSPVAG00000007340CELF110099.531Pteropus_vampyrus
ENSG00000149187CELF110087.500ENSPNYG00000023666-10080.882Pundamilia_nyererei
ENSG00000149187CELF18388.889ENSPNYG00000023719-8871.940Pundamilia_nyererei
ENSG00000149187CELF110088.421ENSPNAG00000013418celf19681.870Pygocentrus_nattereri
ENSG00000149187CELF110099.179ENSRNOG00000010379Celf110099.384Rattus_norvegicus
ENSG00000149187CELF1100100.000ENSRBIG00000042406CELF1100100.000Rhinopithecus_bieti
ENSG00000149187CELF1100100.000ENSRROG00000032588CELF110099.805Rhinopithecus_roxellana
ENSG00000149187CELF1100100.000ENSSBOG00000021912CELF110089.105Saimiri_boliviensis_boliviensis
ENSG00000149187CELF110098.718ENSSHAG00000017438CELF110098.563Sarcophilus_harrisii
ENSG00000149187CELF110089.474ENSSFOG00015019353celf19785.855Scleropages_formosus
ENSG00000149187CELF110091.892ENSSMAG00000013827celf19683.826Scophthalmus_maximus
ENSG00000149187CELF110088.421ENSSDUG00000011558celf19683.629Seriola_dumerili
ENSG00000149187CELF110091.892ENSSLDG00000012863celf110086.214Seriola_lalandi_dorsalis
ENSG00000149187CELF1100100.000ENSSARG00000003207CELF110093.621Sorex_araneus
ENSG00000149187CELF110097.436ENSSPUG00000004228CELF110096.512Sphenodon_punctatus
ENSG00000149187CELF110088.421ENSSPAG00000009569celf110085.193Stegastes_partitus
ENSG00000149187CELF1100100.000ENSSSCG00000013233CELF110099.588Sus_scrofa
ENSG00000149187CELF110097.436ENSTGUG00000010377CELF110095.930Taeniopygia_guttata
ENSG00000149187CELF110085.714ENSTRUG00000025064-7986.667Takifugu_rubripes
ENSG00000149187CELF110088.421ENSTRUG00000000617celf110066.871Takifugu_rubripes
ENSG00000149187CELF1100100.000ENSTBEG00000005140CELF18399.338Tupaia_belangeri
ENSG00000149187CELF1100100.000ENSTTRG00000014157CELF110099.588Tursiops_truncatus
ENSG00000149187CELF1100100.000ENSUAMG00000000223CELF110099.353Ursus_americanus
ENSG00000149187CELF1100100.000ENSUMAG00000009218CELF110099.416Ursus_maritimus
ENSG00000149187CELF1100100.000ENSVPAG00000000336CELF110086.008Vicugna_pacos
ENSG00000149187CELF1100100.000ENSVVUG00000023439CELF110099.588Vulpes_vulpes
ENSG00000149187CELF110092.632ENSXETG00000009044celf110088.641Xenopus_tropicalis
ENSG00000149187CELF18859.763ENSXCOG00000017706-8760.117Xiphophorus_couchianus
ENSG00000149187CELF110083.158ENSXMAG00000029339-10072.016Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000381regulation of alternative mRNA splicing, via spliceosome21873635.IBAProcess
GO:0000900translation repressor activity, mRNA regulatory element binding10893231.NASFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding21873635.IBAFunction
GO:0003723RNA binding16946708.IDAFunction
GO:0003729mRNA binding21873635.IBAFunction
GO:0003729mRNA binding14726956.IDAFunction
GO:0005515protein binding16946708.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus11158314.IDAComponent
GO:0005634nucleus10893231.NASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0006376mRNA splice site selection21873635.IBAProcess
GO:0006376mRNA splice site selection11158314.IDAProcess
GO:0006376mRNA splice site selection-ISSProcess
GO:0006397mRNA processing8948631.TASProcess
GO:0007281germ cell development10893231.NASProcess
GO:0009792embryo development ending in birth or egg hatching10893231.NASProcess
GO:0016020membrane19946888.HDAComponent
GO:0016246RNA interference10893231.NASProcess
GO:0017148negative regulation of translation-IEAProcess
GO:0036002pre-mRNA binding11158314.IDAFunction
GO:0042835BRE binding10893231.IDAFunction
GO:0043484regulation of RNA splicing16946708.IDAProcess
GO:1990904ribonucleoprotein complex21873635.IBAComponent
GO:1990904ribonucleoprotein complex10893231.NASComponent
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