EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26700459	Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells.	Oncotarget	2016 Jan 19	Zong ZH	doi: 10.18632/oncotarget.6636.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	119048748	Frame_Shift_Ins	novel	*L711Ifs5**	0.04
BLCA	chr11	119048749	Missense_Mutation	novel	D710E	0.04
BLCA	chr11	119052732	Missense_Mutation	NA	D298H	0.24
BLCA	chr11	119047982	Silent	rs200889803	L825L	0.26
BLCA	chr11	119054491	Splice_Region	novel		0.36
BLCA	chr11	119048868	Missense_Mutation	NA	E671K	0.53
BLCA	chr11	119047965	Missense_Mutation	novel	H831R	0.55
BLCA	chr11	119046760	Missense_Mutation	rs147237122	A880T	0.28
BRCA	chr11	119056137	Silent	NA	Q8Q	0.15
BRCA	chr11	119048801	Missense_Mutation	rs372581628	R693Q	0.06
BRCA	chr11	119046649	Missense_Mutation	rs200784367	R917W	0.64
BRCA	chr11	119048801	Missense_Mutation	NA	R693P	0.41
BRCA	chr11	119045608	Silent	novel	K995K	0.11
BRCA	chr11	119055509	Missense_Mutation	NA	D83G	0.29
BRCA	chr11	119055234	Missense_Mutation	NA	E124K	0.15
BRCA	chr11	119055204	Missense_Mutation	NA	V134L	1
BRCA	chr11	119055838	Silent	novel	L33L	0.09
BRCA	chr11	119051528	Missense_Mutation	NA	R479H	0.24
CESC	chr11	119054618	Missense_Mutation	rs781950705	R185H	0.46
CESC	chr11	119052133	Missense_Mutation	NA	R388W	0.12
CESC	chr11	119046630	Missense_Mutation	novel	G923E	0.09
CESC	chr11	119048292	Missense_Mutation	rs782654390	A778T	0.3
CESC	chr11	119052726	Missense_Mutation	rs782034654	R300W	0.3
CESC	chr11	119054171	Silent	NA	V248V	0.43
CESC	chr11	119051518	Missense_Mutation	NA	I482M	0.33
CESC	chr11	119048271	Missense_Mutation	novel	E785K	0.38
COAD	chr11	119045602	Silent	rs573944250	D997D	0.16
COAD	chr11	119055317	Missense_Mutation	NA	T96M	0.19
COAD	chr11	119047805	Missense_Mutation	novel	I842F	0.21
COAD	chr11	119051053	Silent	rs201408509	G549G	0.46
COAD	chr11	119049058	Frame_Shift_Del	novel	*K651Rfs46**	0.13
COAD	chr11	119055008	Missense_Mutation	rs781789542	R158C	0.3
COAD	chr11	119052813	Missense_Mutation	NA	G271W	0.24
COAD	chr11	119048292	Missense_Mutation	rs782654390	A778T	0.35
COAD	chr11	119051911	Missense_Mutation	rs782770261	A416T	0.36
COAD	chr11	119046789	Missense_Mutation	novel	A870G	0.15
COAD	chr11	119047999	Missense_Mutation	rs782759376	E820K	0.2
COAD	chr11	119049789	Missense_Mutation	novel	S572A	0.11
COAD	chr11	119051053	Silent	rs201408509	G549G	0.22
COAD	chr11	119047999	Missense_Mutation	rs782759376	E820K	0.35
COAD	chr11	119055764	Missense_Mutation	NA	E57D	0.25
COAD	chr11	119045555	3'UTR	rs782310949		0.3
COAD	chr11	119052655	Silent	rs376041557	N323N	0.32
COAD	chr11	119049274	Intron	rs782066514		0.44
ESCA	chr11	119051827	Missense_Mutation	rs375666355	P444S	0.39
ESCA	chr11	119048271	Missense_Mutation	novel	E785K	0.09
ESCA	chr11	119048012	Silent	novel	R815R	0.14
GBM	chr11	119048337	Frame_Shift_Del	NA	*S763Pfs30**	0.37
GBM	chr11	119055185	Missense_Mutation	rs781897557	S140L	0.33
GBM	chr11	119051147	Missense_Mutation	novel	T518R	0.05
GBM	chr11	119048533	Missense_Mutation	novel	E732D	0.27
GBM	chr11	119051439	Missense_Mutation	rs377216245	R509W	0.47
GBM	chr11	119052133	Missense_Mutation	NA	R388W	0.22
GBM	chr11	119052306	Missense_Mutation	rs201660855	E371K	0.24
GBM	chr11	119055836	Silent	novel	L33L	0.21
GBM	chr11	119046661	Nonsense_Mutation	novel	K913*	0.23
GBM	chr11	119048274	Missense_Mutation	novel	D784N	0.22
GBM	chr11	119048782	Silent	rs781827314	I699I	0.23
GBM	chr11	119052692	Missense_Mutation	rs781887339	R311L	0.24
GBM	chr11	119046449	Frame_Shift_Ins	novel	*E952Afs10**	0.04
HNSC	chr11	119054669	Missense_Mutation	novel	P168L	0.15
HNSC	chr11	119054622	Missense_Mutation	novel	E184K	0.13
HNSC	chr11	119054665	Silent	rs782767234	I169I	0.26
HNSC	chr11	119051911	Missense_Mutation	rs782770261	A416T	0.51
HNSC	chr11	119051097	Missense_Mutation	rs781956168	E535K	0.08
KIRC	chr11	119049315	Intron	novel		0.36
KIRC	chr11	119046706	Silent	NA	L898L	0.33
KIRC	chr11	119051564	Missense_Mutation	rs782455800	R467Q	0.22
KIRC	chr11	119055189	Missense_Mutation	NA	S139C	0.19
LAML	chr11	119049558	Nonsense_Mutation	novel	Q602*	0.06
LAML	chr11	119048506	Silent	rs782506920	N741N	0.25
LGG	chr11	119048734	Silent	novel	K715K	0.07
LIHC	chr11	119051900	Silent	NA	A419A	0.32
LIHC	chr11	119054238	Splice_Site	NA	X227_splice	0.19
LIHC	chr11	119052305	Missense_Mutation	novel	E371G	0.32
LUAD	chr11	119046635	Missense_Mutation	novel	K921N	0.33
LUAD	chr11	119051525	Missense_Mutation	NA	K480R	0.28
LUAD	chr11	119055541	Silent	NA	V72V	0.23
LUAD	chr11	119055314	Missense_Mutation	novel	L97R	0.18
LUAD	chr11	119055252	Missense_Mutation	NA	A118S	0.13
LUAD	chr11	119047998	Missense_Mutation	novel	E820A	0.23
LUAD	chr11	119055802	Missense_Mutation	rs568395407	M45V	0.27
LUAD	chr11	119045831	Missense_Mutation	NA	G963V	0.12
LUAD	chr11	119054650	Missense_Mutation	NA	I174M	0.09
LUAD	chr11	119048033	Silent	NA	L808L	0.28
LUAD	chr11	119054616	Nonsense_Mutation	NA	R186*	0.11
LUAD	chr11	119055301	Missense_Mutation	novel	Q101H	0.05
LUSC	chr11	119051942	Silent	novel	L405L	0.39
LUSC	chr11	119051943	Missense_Mutation	novel	L405P	0.41
LUSC	chr11	119046642	Missense_Mutation	novel	K919T	0.11
LUSC	chr11	119056103	Missense_Mutation	novel	A20P	0.1
LUSC	chr11	119046610	Frame_Shift_Del	novel	*L930Sfs31**	0.16
LUSC	chr11	119054622	Nonsense_Mutation	novel	E184*	0.12
LUSC	chr11	119045627	Missense_Mutation	novel	G989A	0.17
LUSC	chr11	119046582	Frame_Shift_Ins	novel	*E939Gfs11**	0.49
LUSC	chr11	119051116	Silent	novel	F528F	0.36
LUSC	chr11	119051521	Silent	novel	V481V	0.22
LUSC	chr11	119049178	Missense_Mutation	rs562490154	G611E	0.15
LUSC	chr11	119048484	Missense_Mutation	NA	E749Q	0.12
OV	chr11	119048065	Missense_Mutation	novel	L798V	0.13
OV	chr11	119045404	3'UTR	novel		0.3
OV	chr11	119045626	Frame_Shift_Del	novel	*Q990Rfs5**	0.05
OV	chr11	119048302	Silent	novel	K774K	0.06
PAAD	chr11	119048364	Silent	rs370754185	L754L	0.21
PRAD	chr11	119048851	Silent	rs375091924	G676G	0.31
READ	chr11	119052740	Missense_Mutation	NA	R295I	0.32
READ	chr11	119048859	Missense_Mutation	novel	P674T	0.21
READ	chr11	119045331	3'UTR	rs115695817		0.14
READ	chr11	119048850	Missense_Mutation	rs147081612	V677I	0.97
READ	chr11	119055284	Missense_Mutation	NA	Q107R	0.38
SARC	chr11	119046571	Missense_Mutation	rs201317769	P943S	0.12
SKCM	chr11	119049071	Missense_Mutation	novel	P647S	0.37
SKCM	chr11	119051563	Silent	novel	R467R	0.15
SKCM	chr11	119051564	Missense_Mutation	rs782455800	R467Q	0.15
SKCM	chr11	119045485	3'UTR	novel		0.75
SKCM	chr11	119045789	Missense_Mutation	novel	P977L	0.18
SKCM	chr11	119045790	Missense_Mutation	novel	P977S	0.18
SKCM	chr11	119054518	Silent	NA	R218R	0.4
SKCM	chr11	119049103	Missense_Mutation	NA	P636L	0.4
SKCM	chr11	119051098	Silent	novel	Y534Y	0.36
SKCM	chr11	119051099	Missense_Mutation	novel	Y534C	0.35
STAD	chr11	119055267	Missense_Mutation	novel	V113I	0.04
STAD	chr11	119052726	Missense_Mutation	rs782034654	R300W	0.43
STAD	chr11	119054588	Missense_Mutation	novel	A195V	0.16
STAD	chr11	119049100	Frame_Shift_Del	NA	*P637Hfs60**	0.36
STAD	chr11	119049833	Missense_Mutation	NA	E557A	0.05
STAD	chr11	119048795	Missense_Mutation	NA	M695T	0.1
STAD	chr11	119051579	Missense_Mutation	NA	L462P	0.08
STAD	chr11	119045619	Missense_Mutation	novel	R992W	0.31
STAD	chr11	119052097	Missense_Mutation	rs781881422	V400M	0.36
STAD	chr11	119055248	Missense_Mutation	rs781974767	R119H	0.07
STAD	chr11	119049118	Missense_Mutation	NA	E631A	0.2
STAD	chr11	119047813	Frame_Shift_Ins	NA	*A839Gfs13**	0.35
STAD	chr11	119054550	Missense_Mutation	NA	A208T	0.29
STAD	chr11	119054655	Missense_Mutation	novel	V173M	0.39
STAD	chr11	119047813	Frame_Shift_Ins	NA	*A839Gfs13**	0.27
STAD	chr11	119048812	Silent	rs782680299	P689P	0.24
STAD	chr11	119051053	Silent	rs201408509	G549G	0.19
THYM	chr11	119044310	3'UTR	novel		0.17
THYM	chr11	119046654	Missense_Mutation	novel	R915L	0.28
UCEC	chr11	119044535	3'UTR	novel		0.36
UCEC	chr11	119048047	Silent	novel	L804L	0.44
UCEC	chr11	119051446	Missense_Mutation	novel	E506D	0.33
UCEC	chr11	119054993	Missense_Mutation	novel	D163Y	0.16
UCEC	chr11	119047951	Missense_Mutation	NA	L836F	0.14
UCEC	chr11	119048772	Silent	rs200858668	L703L	0.71
UCEC	chr11	119051857	Missense_Mutation	novel	P434T	0.4
UCEC	chr11	119052710	Missense_Mutation	novel	A305V	0.5
UCEC	chr11	119045601	Missense_Mutation	NA	E998K	0.47
UCEC	chr11	119054551	Silent	rs782645449	T207T	0.5
UCEC	chr11	119055317	Missense_Mutation	NA	T96M	0.31
UCEC	chr11	119045496	3'UTR	rs181046821		0.3
UCEC	chr11	119052345	Missense_Mutation	novel	R358W	0.36
UCEC	chr11	119055289	Silent	novel	G105G	0.1
UCEC	chr11	119051565	Missense_Mutation	rs782712243	R467W	0.41
UCEC	chr11	119052693	Missense_Mutation	novel	R311C	0.34
UCEC	chr11	119055317	Missense_Mutation	NA	T96M	0.41
UCEC	chr11	119048791	Silent	novel	V696V	0.05
UCEC	chr11	119051550	Missense_Mutation	NA	R472W	0.27
UCEC	chr11	119055263	Missense_Mutation	NA	A114D	0.18
UCEC	chr11	119055517	Missense_Mutation	NA	F80L	0.25
UCEC	chr11	119055504	Missense_Mutation	rs142522320	A85T	0.14
UCEC	chr11	119051883	Missense_Mutation	rs149886341	A425V	0.48
UCEC	chr11	119044630	3'UTR	novel		0.24
UCEC	chr11	119045601	Missense_Mutation	NA	E998K	0.19
UCEC	chr11	119052131	Silent	novel	R388R	0.18
UCEC	chr11	119049160	Missense_Mutation	novel	G617V	0.21
UCEC	chr11	119055797	Missense_Mutation	novel	K46N	0.16
UCEC	chr11	119055338	Missense_Mutation	rs781981889	A89V	0.21
UCEC	chr11	119048352	Missense_Mutation	rs782303315	E758K	0.19
UCEC	chr11	119046788	Silent	NA	A870A	0.33
UCEC	chr11	119048311	Silent	novel	I771I	0.45
UCEC	chr11	119049233	Intron	rs200126359		0.5
UCEC	chr11	119044486	3'UTR	rs377511248		0.33
UCEC	chr11	119046745	Missense_Mutation	NA	V885M	0.39
UCEC	chr11	119049596	Missense_Mutation	rs560441682	T589I	0.28
UCEC	chr11	119051507	Missense_Mutation	rs782795154	R486H	0.45
UCEC	chr11	119049156	Silent	NA	E618E	0.08
UCEC	chr11	119051902	Frame_Shift_Del	novel	*A419Qfs14**	0.39
UCEC	chr11	119052786	Nonsense_Mutation	novel	R280*	0.43
UCEC	chr11	119049328	Intron	novel		0.25
UCEC	chr11	119055235	Silent	rs782262662	H123H	0.11
UCEC	chr11	119055039	Missense_Mutation	NA	E147D	0.25
UCEC	chr11	119049575	Missense_Mutation	NA	N596S	0.37
UCEC	chr11	119054502	Missense_Mutation	novel	T224A	0.32
UCEC	chr11	119045812	Silent	novel	T969T	0.1
UCEC	chr11	119044603	3'UTR	novel		0.33
UCEC	chr11	119048292	Missense_Mutation	rs782654390	A778T	0.28
UCEC	chr11	119052311	Missense_Mutation	novel	S369N	0.44
UCEC	chr11	119045654	Splice_Site	novel	X980_splice	0.43
UCEC	chr11	119055551	Missense_Mutation	novel	P69Q	0.25
UCEC	chr11	119052324	Nonsense_Mutation	novel	Q365*	0.29
UCEC	chr11	119045607	Missense_Mutation	NA	N996D	0.34
UCEC	chr11	119046423	Nonsense_Mutation	NA	E961*	0.34
UCEC	chr11	119046463	Missense_Mutation	NA	Q947H	0.06
UCEC	chr11	119048079	Missense_Mutation	NA	M793T	0.39
UCEC	chr11	119048782	Silent	rs781827314	I699I	0.54
UCEC	chr11	119049028	Missense_Mutation	NA	S661F	0.14
UCEC	chr11	119049287	Intron	novel		0.19
UCEC	chr11	119051565	Missense_Mutation	rs782712243	R467W	0.36
UCEC	chr11	119052099	Missense_Mutation	novel	A399V	0.18
UCEC	chr11	119052383	Missense_Mutation	novel	R345H	0.18
UCEC	chr11	119052773	Missense_Mutation	novel	A284V	0.21
UCEC	chr11	119054141	Silent	novel	Q258Q	0.12
UCEC	chr11	119054237	Splice_Site	novel	X227_splice	0.29
UCEC	chr11	119055315	Silent	novel	L97L	0.39
UCEC	chr11	119054641	Silent	NA	P177P	0.17
UCEC	chr11	119049802	Silent	rs202017398	S567S	0.63
UCEC	chr11	119047813	Missense_Mutation	rs372174234	A839G	0.11
UCEC	chr11	119048028	Missense_Mutation	novel	F810C	0.49
UCEC	chr11	119048544	Nonsense_Mutation	rs372068451	R729*	0.49
UCEC	chr11	119051439	Missense_Mutation	rs377216245	R509W	0.09

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2843	0.00015732
CESC	DEL	0.5051	1.0762e-32
CHOL	DEL	0.2778	0.048655
ESCA	AMP	0.0924	0.018342
KIRP	DEL	0.0972	2.839e-05
LGG	AMP	0.1209	6.1002e-05
LIHC	DEL	0.2	0.00030497
LUAD	DEL	0.155	4.2393e-06
PRAD	DEL	0.0711	0.00026046
READ	DEL	0.1879	0.054114
SARC	DEL	0.4397	1.8105e-09
STAD	DEL	0.1519	8.3734e-05
TGCT	DEL	0.7667	0.21504
UCS	DEL	0.3929	0.086462
UVM	DEL	0.075	0.023516

Survival Analysis

Cancer	P-value	Q-value
STAD	0.046	Kaplan-Meier Survival Analysis
SARC	0.0047	Kaplan-Meier Survival Analysis
ACC	0.015	Kaplan-Meier Survival Analysis
HNSC	0.013	Kaplan-Meier Survival Analysis
TGCT	0.048	Kaplan-Meier Survival Analysis
KIRP	0.05	Kaplan-Meier Survival Analysis
COAD	0.035	Kaplan-Meier Survival Analysis
BLCA	0.011	Kaplan-Meier Survival Analysis
CESC	0.00074	Kaplan-Meier Survival Analysis
READ	0.046	Kaplan-Meier Survival Analysis
KICH	0.028	Kaplan-Meier Survival Analysis
UCEC	0.004	Kaplan-Meier Survival Analysis
LIHC	0.003	Kaplan-Meier Survival Analysis
LGG	0.0091	Kaplan-Meier Survival Analysis
THCA	0.037	Kaplan-Meier Survival Analysis
UVM	0.019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149428 (Gene tree)
Gene ID: 10525
Gene Symbol: HYOU1
Alias: ORP150|HSP12A|Grp170
Full Name: hypoxia up-regulated 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,062 bases
Position: chr11:119,044,185-119,057,246
Accession: 16931
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29448096	AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.	Biochem Biophys Res Commun	2018 Mar 4	Liu JQ	doi: 10.1016/j.bbrc.2018.02.095
20719828	Implication of oxygen-regulated protein 150 (ORP150) in apoptosis induced by proteasome inhibitors in human thyroid cancer cells.	J Clin Endocrinol Metab	2010 Nov	Gao YY	doi: 10.1210/jc.2010-1043

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000617285	HYOU1-220	4529	XM_005271392	ENSP00000480150	999 (aa)	XP_005271449	Q9Y4L1
ENST00000531682	HYOU1-208	319	-	-	- (aa)	-	-
ENST00000532519	HYOU1-212	2162	-	ENSP00000467866	678 (aa)	-	K7EQK2
ENST00000529174	HYOU1-205	549	-	-	- (aa)	-	-
ENST00000543287	HYOU1-215	2464	-	ENSP00000442727	38 (aa)	-	J3KSR2
ENST00000527038	HYOU1-203	629	-	ENSP00000463742	149 (aa)	-	J3QQH7
ENST00000526656	HYOU1-202	862	-	ENSP00000463318	211 (aa)	-	J3QL06
ENST00000610597	HYOU1-216	491	-	ENSP00000484622	92 (aa)	-	A0A087X214
ENST00000527738	HYOU1-204	809	-	-	- (aa)	-	-
ENST00000621959	HYOU1-221	3358	-	ENSP00000484186	937 (aa)	-	A0A087X054
ENST00000533381	HYOU1-213	694	-	-	- (aa)	-	-
ENST00000531968	HYOU1-210	550	-	ENSP00000464026	38 (aa)	-	J3KSR2
ENST00000530467	HYOU1-206	552	-	ENSP00000479845	102 (aa)	-	A0A087WW13
ENST00000531694	HYOU1-209	2357	-	-	- (aa)	-	-
ENST00000532421	HYOU1-211	582	-	ENSP00000463515	154 (aa)	-	J3QLE9
ENST00000612687	HYOU1-217	4360	-	ENSP00000483106	937 (aa)	-	A0A087X054
ENST00000534233	HYOU1-214	711	-	ENSP00000462951	224 (aa)	-	J3KTF1
ENST00000614711	HYOU1-219	3057	-	ENSP00000480248	677 (aa)	-	A0A087WWI4
ENST00000614668	HYOU1-218	1569	-	ENSP00000482199	147 (aa)	-	Q9BST8
ENST00000526354	HYOU1-201	568	-	-	- (aa)	-	-
ENST00000622474	HYOU1-222	549	-	-	- (aa)	-	-
ENST00000530473	HYOU1-207	2023	-	ENSP00000431874	656 (aa)	-	E9PJ21

Gene Model

Click here to download ENSG00000149428's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000149428	Bronchodilator Agents	1E-6	26634245
ENSG00000149428	Lung Volume Measurements	1E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000149428	rs147134271	11	119053427	G	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.231	GO_0097366\|EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149428's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149428	HYOU1	100	93.598	ENSMUSG00000032115	Hyou1	100	92.092	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002931	response to ischemia	-	ISS	Process
GO:0005515	protein binding	26496610.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	9020069.10837345.	NAS	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005790	smooth endoplasmic reticulum	-	ISS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006888	ER to Golgi vesicle-mediated transport	10837345.	IDA	Process
GO:0006898	receptor-mediated endocytosis	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0034663	endoplasmic reticulum chaperone complex	21873635.	IBA	Component
GO:0034976	response to endoplasmic reticulum stress	9020069.	IEP	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0051087	chaperone binding	10837345.	ISS	Function
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:0071456	cellular response to hypoxia	21873635.	IBA	Process
GO:0071456	cellular response to hypoxia	10837345.	IDA	Process
GO:0071456	cellular response to hypoxia	9020069.	IEP	Process
GO:0071682	endocytic vesicle lumen	-	TAS	Component
GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	21873635.	IBA	Process
GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	10037731.	IDA	Process
GO:1903382	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.