EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28478797Effect of matrix rigidity on organ-specific capture of tumor cells by flow.Cell Mol Biol (Noisy-le-grand)2017 Apr 29Ma Pdoi: 10.14715/cmb/2017.63.4.2.
15757908Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells.J Biol Chem2005 May 13Kuwada SK-
21400218Expression of Toll-like receptor 4 and beta 1 integrin in breast cancer.Med Oncol2012 JunPetricevic Bdoi: 10.1007/s12032-011-9885-0
15500293Metastatic properties of prostate cancer cells are controlled by VEGF.Cell Commun Adhes2004 Jan-FebChen J-
23936390miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin β1 and matrix metalloproteinase2 (MMP2).PLoS One2013 Aug 6Wang Hdoi: 10.1371/journal.pone.0070192
17638891Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells.Cancer Res2007 Jul 15Patrawala L-
27832972CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling.Cancer Lett2017 Jan 28Wang Zdoi: 10.1016/j.canlet.2016.10.043
28377405The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.Sci Signal2017 Apr 4Becchetti Adoi: 10.1126/scisignal.aaf3236.
24448647The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases.Sci Signal2014 Jan 21Odagiri Hdoi: 10.1126/scisignal.2004612.
16762342Integrin alpha2beta1 mediates the anti-angiogenic and anti-tumor activities of angiocidin, a novel tumor-associated protein.Exp Cell Res2006 Aug 1Sabherwal Y-
18787945Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells.Breast Cancer Res Treat2009 NovPan Hdoi: 10.1007/s10549-008-0179-y
19190332An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors.Cancer Res2009 Feb 15Ferreira Mdoi: 10.1158/0008-5472.CAN-08-3051
26239765Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin.J Cell Biochem2016 FebSroka ICdoi: 10.1002/jcb.25300.
27353038Angiopoietin-2 promotes ER+ breast cancer cell survival in bone marrow niche.Endocr Relat Cancer2016 AugHan HHdoi: 10.1530/ERC-16-0086
18048360Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface.J Biol Chem2008 Feb 1Radjabi AR-
25263164Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer.DNA Repair (Amst)2014 NovSantidrian AFdoi: 10.1016/j.dnarep.2014.08.006
25212537A first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors.Cancer Chemother Pharmacol2014 NovMateo Jdoi: 10.1007/s00280-014-2576-8
20432448The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion.J Cell Physiol2010 AugSroka ICdoi: 10.1002/jcp.22149.
26377974CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.Oncotarget2015 Oct 6Zhou Pdoi: 10.18632/oncotarget.4896.
17498594Ameloblastoma and adenomatoid odontogenic tumor: the role of alpha2beta1, alpha3beta1, and alpha5beta1 integrins in local invasiveness and architectural characteristics.Ann Diagn Pathol2007 JunSouza Andrade ES-
15024036Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis.J Cell Biol2004 Mar 15Wang H-
20388801Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis.Cancer Res2010 Apr 15Garmy-Susini Bdoi: 10.1158/0008-5472.CAN-09-3761
14525968Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils.J Leukoc Biol2004 JanSullivan GW-
20007695Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4.J Biol Chem2010 Mar 5Saito Ydoi: 10.1074/jbc.M109.027581
21119363Expression and correlation of Lewis y antigen and integrins α5 and β1 in ovarian serous and mucinous carcinoma.Int J Gynecol Cancer2010 DecLi Qdoi: 10.1111/IGC.0b013e3181ea7ecb.
15509657Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.Mol Biol Cell2005 JanLynch L-
16547007A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth.J Biol Chem2006 May 26Chaurasia P-
19714342Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas.Int J Colorectal Dis2010 JanFan LFdoi: 10.1007/s00384-009-0791-2
17380111Lubrol-RAFTs in melanoma cells: a molecular platform for tumor-promoting ephrin-B2-integrin-beta1 interaction.J Invest Dermatol2007 JulMeyer S-
26418968CD151 promotes α3β1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion.Cancer Biol Ther2015Zevian SCdoi: 10.1080/15384047.2015.1095396
24036548Autophagy modulates cell migration and β1 integrin membrane recycling.Cell Cycle2013 Oct 15Tuloup-Minguez Vdoi: 10.4161/cc.26298
25356755CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling.Oncotarget2014 Dec 15Baldwin LA-
24388360SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma.Mol Oncol2014 MarJing Ydoi: 10.1016/j.molonc.2013.12.003
18794852Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation.Lab Invest2008 NovFiorilli Pdoi: 10.1038/labinvest.2008.89
25237190Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with α5β1 integrin.J Biol Chem2014 Nov 7Lee HSdoi: 10.1074/jbc.M114.572594
19775453The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells.BMC Cancer2009 Sep 23Dai JYdoi: 10.1186/1471-2407-9-337.
14532964Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells.Int J Oncol2003 NovSuzuki K-
27066976Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway.Biochim Biophys Acta2016 JulKundu Mdoi: 10.1016/j.bbamcr.2016.04.004
20522645Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial {alpha}5{beta}1 integrin.Am J Pathol2010 JulSun WYdoi: 10.2353/ajpath.2010.091016
19323811Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins.BMC Cancer2009 Mar 26Castell??-Cros Rdoi: 10.1186/1471-2407-9-94.
19469865Overexpression of malignancy-associated laminins and laminin receptors by angiotropic human melanoma cells in a chick chorioallantoic membrane model.J Cutan Pathol2009 DecLugassy Cdoi: 10.1111/j.1600-0560.2009.01273.x.
21135504The αβ integrin is a metastasis suppressor in mouse models and human cancer.J Clin Invest2011 JanRamirez NEdoi: 10.1172/JCI42328
26334393Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism.Oncotarget2015 Oct 6Zhang HFdoi: 10.18632/oncotarget.5027.
18378436Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin.Matrix Biol2008 JunGama-de-Souza LNdoi: 10.1016/j.matbio.2008.02.007
28537888High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1.Oncotarget2017 Jul 18Liang Zdoi: 10.18632/oncotarget.17650.
29750423NRP1 knockdown promotes the migration and invasion of human neuroblastoma-derived SKNAS cells via the activation of β1integrin expression.Int J Oncol2018 JulIshizuka Ydoi: 10.3892/ijo.2018.4397
29259017Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin α9β1-Mediated YAP Inhibition.Cancer Res2018 Feb 15Sun Zdoi: 10.1158/0008-5472.CAN-17-1597
30194450VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop.Oncogene2019 FebBoudria Adoi: 10.1038/s41388-018-0486-7
30065025EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors.EMBO Mol Med2018 SepDudvarski Stankovi Ndoi: 10.15252/emmm.201708420.
21341269Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.J Pathol2011 AprAllen MDdoi: 10.1002/path.2833
21170718Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor α5β1 in the process.Eur J Nutr2011 SepSen Tdoi: 10.1007/s00394-010-0158-z
16504015Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression.BMC Cell Biol2006 Feb 20Sawai H-
27499367miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1.Oncol Rep2016 OctGong Cdoi: 10.3892/or.2016.4985
22898815Matrix metalloproteinase-2 cleavage of the β1 integrin ectodomain facilitates colon cancer cell motility.J Biol Chem2012 Oct 19Kryczka Jdoi: 10.1074/jbc.M112.384909
22232555Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.J Biol Chem2012 Feb 24Shields MAdoi: 10.1074/jbc.M111.308940
26414794CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer.Int J Cancer2016 Mar 1Izumi Ddoi: 10.1002/ijc.29864
28714035Immunocytochemical stem cell markers can predict clinical stage of breast cancer.Oncol Rep2017 SepGuti??rrez Diez PJdoi: 10.3892/or.2017.5820
29393491β3GnT8 regulates oxaliplatin resistance by altering integrinβ1 glycosylation in colon cancer cells.Oncol Rep2018 AprShen Ldoi: 10.3892/or.2018.6243
29402961ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer.Sci Rep2018 Feb 5Pellinen Tdoi: 10.1038/s41598-018-20161-2.
29371698Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.Exp Mol Med2018 Jan 26Jeong BYdoi: 10.1038/emm.2017.248.
17726369Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasion.Cancer Biol Ther2007 AugFukasawa M-
17312461Determination of the ligand-binding specificities of the alpha2beta1 and alpha1beta1 integrins in a novel 3-dimensional in vitro model of pancreatic cancer.Pancreas2007 MarGrzesiak JJ-
21613543Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.Mol Biol Cell2011 Jul 15Wendt MKdoi: 10.1091/mbc.E11-04-0306
25426561New mechanistic insights of integrin β1 in breast cancer bone colonization.Oncotarget2015 Jan 1Thibaudeau L-
22740085Cancer stem-like cells enriched with CD29 and CD44 markers exhibit molecular characteristics with epithelial-mesenchymal transition in squamous cell carcinoma.Arch Dermatol Res2013 JanGeng Sdoi: 10.1007/s00403-012-1260-2
23857544Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin β1 and β3.J Surg Oncol2013 AugShen Zdoi: 10.1002/jso.23353.
22386417Engagement of integrinβ1 induces resistance of bladder cancer cells to mitomycin-C.Urology2012 MarZhang CJdoi: 10.1016/j.urology.2011.12.012.
19005162Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789.Am J Physiol Cell Physiol2009 JanCraig DHdoi: 10.1152/ajpcell.00355.2008
24982892Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration.Biomed Res Int2014Klahan Sdoi: 10.1155/2014/536591
12931024Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer.Oncology2003Sawai H-
23436775GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.EMBO Mol Med2013 AprGoel HLdoi: 10.1002/emmm.201202078
24939894The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin β.Sci Signal2014 Jun 17Xu Ydoi: 10.1126/scisignal.2005170.
23951036Lung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasiveness.PLoS One2013 Aug 8Li Xdoi: 10.1371/journal.pone.0070905
23883667β1-Integrin via NF-??B signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer.Breast Cancer Res2013Nam JM-
25041835Association of CD98, integrin β1, integrin β3 and Fak with the progression and liver metastases of colorectal cancer.Pathol Res Pract2014 OctSun Cdoi: 10.1016/j.prp.2014.06.016
19130304Integrin expression levels correlate with invasion, metastasis and prognosis of oral squamous cell carcinoma.Pathol Oncol Res2009 SepOhara Tdoi: 10.1007/s12253-008-9142-9.
25111005RAD9 enhances radioresistance of human prostate cancer cells through regulation of ITGB1 protein levels.Prostate2014 OctBroustas CGdoi: 10.1002/pros.22842
21618249Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer.J Surg Oncol2011 OctZhao ZSdoi: 10.1002/jso.21984
19780039Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells.J Cell Physiol2010 JanLindberg Kdoi: 10.1002/jcp.21932.
21119598Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis.Oncogene2011 Mar 31Mitra AKdoi: 10.1038/onc.2010.532
26675717Gene expression profiling combined with functional analysis identify integrin beta1 (ITGB1) as a potential prognosis biomarker in triple negative breast cancer.Pharmacol Res2016 FebKlahan Sdoi: 10.1016/j.phrs.2015.12.004
26256210Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.Dev Cell2015 Aug 24Wang Ydoi: 10.1016/j.devcel.2015.06.015
20565758Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer.Mol Cancer2010 Jun 17Dingemans AMdoi: 10.1186/1476-4598-9-152.
21478906β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells.Oncogene2011 Sep 29Morello Vdoi: 10.1038/onc.2011.107
23536555Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.Cancer Res2013 May 15Trerotola Mdoi: 10.1158/0008-5472.CAN-12-3266
26386190HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling.Toxicol Appl Pharmacol2015 Dec 1Chen IHdoi: 10.1016/j.taap.2015.09.011
20826546Prolactin receptor-integrin cross-talk mediated by SIRPα in breast cancer cells.Mol Cancer Res2010 OctGalbaugh Tdoi: 10.1158/1541-7786.MCR-10-0130
23359252β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1.J Cell Physiol2013 JulGoel HLdoi: 10.1002/jcp.24323.
21567400Stromal cell-derived factor-1/CXC receptor 4 and β1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells.J Cell Physiol2012 MarHuang WSdoi: 10.1002/jcp.22831.
16547500Cholecystokinin-2 receptor modulates cell adhesion through beta 1-integrin in human pancreatic cancer cells.Oncogene2006 Jul 27Cayrol C-
24793790Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis.Oncogene2015 Apr 2Jin JKdoi: 10.1038/onc.2014.116
23148235Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.J Cell Biol2012 Nov 12Reymond Ndoi: 10.1083/jcb.201205169.
24248895Increased expression of α5β1-integrin is a prognostic marker for patients with gastric cancer.Clin Transl Oncol2014 JulRen Jdoi: 10.1007/s12094-013-1133-y
23532895Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrin β1.Prostate2013 AugShin Mdoi: 10.1002/pros.22664
19123990Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells.Mol Imaging2008 Sep-OctSameni M-
20333644Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.J Cell Physiol2010 JulGoel HLdoi: 10.1002/jcp.22116.
26693891Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network.Int J Biochem Cell Biol2016 FebYang Jdoi: 10.1016/j.biocel.2015.12.004
23441154Integrative analyses identify osteopontin, LAMB3 and ITGB1 as critical pro-metastatic genes for lung cancer.PLoS One2013Wang XMdoi: 10.1371/journal.pone.0055714
23468528mda-7/IL-24 expression inhibits breast cancer through upregulation of growth arrest-specific gene 3 (gas3) and disruption of β1 integrin function.Mol Cancer Res2013 JunLi YJdoi: 10.1158/1541-7786.MCR-12-0496
19724904AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression.Int J Oncol2009 OctVan Slambrouck S-
24777809SNPs in microRNA-binding sites in the ITGB1 and ITGB3 3'-UTR increase colorectal cancer risk.Cell Biochem Biophys2014 SepYe Pdoi: 10.1007/s12013-014-9962-z.
22370635Integrin α9β1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition.Oncogene2013 Jan 10Gupta SKdoi: 10.1038/onc.2012.41
12372334Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagement.Exp Cell Res2002 Oct 15Festuccia C-
19074826Influence of exogenous tissue factor on estrogen receptor alpha expression in breast cancer cells: involvement of beta1-integrin, PAR2, and mitogen-activated protein kinase activation.Mol Cancer Res2008 DecCollier MEdoi: 10.1158/1541-7786.MCR-08-0109.
24842107Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage.Int J Biochem Cell Biol2014 AugMandal Cdoi: 10.1016/j.biocel.2014.05.015
22894137Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study.Diagn Pathol2012 Aug 16dos Santos PBdoi: 10.1186/1746-1596-7-104.
27004522Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression.Oncol Rep2016 MayXu Ydoi: 10.3892/or.2016.4693
22382453The efficacy evaluation of cryosurgery in pancreatic cancer patients with the expression of CD44v6, integrin-β1, CA199, and CEA.Mol Biotechnol2012 SepZhou Gdoi: 10.1007/s12033-011-9474-7.
12020426Ionizing radiation induces up-regulation of functional beta1-integrin in human lung tumour cell lines in vitro.Int J Radiat Biol2002 MayCordes N-
21071450Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site.J Biol Chem2011 Jan 14Oommen Sdoi: 10.1074/jbc.M110.175158
21558392Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.Cancer Res2011 May 15Mantoni TSdoi: 10.1158/0008-5472.CAN-10-1633
24434582Integrin α3β1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells.J Cell Sci2014 Mar 15Subbaram Sdoi: 10.1242/jcs.131227
12517798Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.Cancer Res2003 Jan 1Arboleda MJ-
24403309β-1,4-Galactosyltransferase III suppresses β1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.Carcinogenesis2014 JunChen CHdoi: 10.1093/carcin/bgu007
24004467Expression of CD44v6 and integrin-β1 for the prognosis evaluation of pancreatic cancer patients after cryosurgery.Diagn Pathol2013 Sep 2Zhou Gdoi: 10.1186/1746-1596-8-146.
24593306Calreticulin activates β1 integrin via fucosylation by fucosyltransferase 1 in J82 human bladder cancer cells.Biochem J2014 May 15Lu YCdoi: 10.1042/BJ20131424.
24807392β1 integrin modulates tumor growth and apoptosis of human colorectal cancer.Oncol Rep2014 JulSong Jdoi: 10.3892/or.2014.3168
25839165Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis.Oncotarget2015 May 10Huang CR-
20127017Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation.Oncol Rep2010 MarLee M-
16103120) controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9.J Biol Chem2005 Oct 21Mitsuzuka K-
21691075Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and β1 integrin activation.Cell Physiol Biochem2011Lee HAdoi: 10.1159/000329979
19930715PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling.Mol Cancer2009 Nov 24Peng Ldoi: 10.1186/1476-4598-8-110.
23007402Epidermal growth factor (EGF) regulates α5β1 integrin activation state in human cancer cell lines through the p90RSK-dependent phosphorylation of filamin A.J Biol Chem2012 Nov 23Vial Ddoi: 10.1074/jbc.M112.389577
18512729Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins.Prostate2008 Sep 1Lai THdoi: 10.1002/pros.20799.
24427350Prognostic value of β1 integrin expression in colorectal liver metastases.Int J Clin Exp Pathol2013 Dec 15Vassos N-
22388103Integrin β1 mediates epithelial growth factor-induced invasion in human ovarian cancer cells.Cancer Lett2012 Jul 28Lau MTdoi: 10.1016/j.canlet.2012.02.028
11996105Expression of beta1-integrins and N-cadherin in bladder cancer and melanoma cell lines.Acta Biochim Pol2000Laidler P-
18676743Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulation.Clin Cancer Res2008 Aug 1Lee MYdoi: 10.1158/1078-0432.CCR-08-0234.
27094578miR-199a-5p regulates β1 integrin through Ets-1 to suppress invasion in breast cancer.Cancer Sci2016 JulLi Wdoi: 10.1111/cas.12952
26903137hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a.Sci Rep2016 Feb 23He Bdoi: 10.1038/srep21955.
24498407MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin β1 [corrected].PLoS One2014 Feb 3Zhao Ydoi: 10.1371/journal.pone.0087938
16773720Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance.World J Gastroenterol2006 Jun 14Ke JJ-
21359179Androgen-induced cell migration: role of androgen receptor/filamin A association.PLoS One2011 Feb 16Castoria Gdoi: 10.1371/journal.pone.0017218.
14633626beta 1C Integrin expression in human endometrial proliferative diseases.Am J Pathol2003 DecLovecchio M-
18940913Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.J Cell Sci2008 Nov 15Tang CHdoi: 10.1242/jcs.029769
15276495Integrin-dependent protein tyrosine phosphorylation is a key regulatory event in collagen-IV-mediated adhesion and proliferation of human lung tumor cell line, Calu-1.Ann Thorac Surg2004 AugMukhopadhyay NK-
27121503The NF-??B subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells.Int J Oncol2016 JulWang Jdoi: 10.3892/ijo.2016.3500
26509557MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.Mol Carcinog2016 NovYao Ydoi: 10.1002/mc.22421
28075475miR-134 suppresses the migration and invasion of nonsmall cell lung cancer by targeting ITGB1.Oncol Rep2017 FebQin Qdoi: 10.3892/or.2017.5350
27589736β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer.Int J Mol Sci2016 Aug 31Yin HLdoi: 10.3390/ijms17091432.
27612856Mesothelial cells interact with tumor cells for the formation of ovarian cancer multicellular spheroids in peritoneal effusions.Clin Exp Metastasis2016 DecMatte I-
27524413RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin.Oncogene2017 Feb 23Hwang MHdoi: 10.1038/onc.2016.277
28145580sp2 -Iminosugar α-glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways.J Cell Physiol2017 DecGueder Ndoi: 10.1002/jcp.25832
27773610The Sal-like 4 - integrin α6β1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells.Biochim Biophys Acta Mol Cell Res2017 JanItou Jdoi: 10.1016/j.bbamcr.2016.10.012
28418095The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.Mol Carcinog2017 SepHedrick Edoi: 10.1002/mc.22662
28988530Hyperexpression of Integrin α5β1 Promotes Resistance of MCF-7 Human Breast Carcinoma Cells to Doxorubicin via ERK Protein Kinase Down-regulation.Biochemistry (Mosc)2017 SepMorozevich GEdoi: 10.1134/S0006297917090048.
28916657Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.Cancer Res2017 Nov 1San Martin Rdoi: 10.1158/0008-5472.CAN-17-0064
28361350FOXM1 transcriptionally regulates expression of integrin β1 in triple-negative breast cancer.Breast Cancer Res Treat2017 JunHamurcu Zdoi: 10.1007/s10549-017-4207-7
27563827Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer.Oncotarget2016 Sep 27Choi Cdoi: 10.18632/oncotarget.11525.
28160423Polymeric Delivery of siRNA against Integrin-β1 (CD29) to Reduce Attachment and Migration of Breast Cancer Cells.Macromol Biosci2017 JunMeenakshi Sundaram DNdoi: 10.1002/mabi.201600430
27715399Proteolytic fragments of fibronectin function as matrikines driving the chemotactic affinity of prostate cancer cells to human bone marrow mesenchymal stromal cells via the α5β1 integrin.Cell Adh Migr2017 Jul 4Joshi Rdoi: 10.1080/19336918.2016.1212139
28560430Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1.Int J Oncol2017 JulJiang Pdoi: 10.3892/ijo.2017.4018
28829502Expression of long non-coding RNA linc-ITGB1 in breast cancer and its influence on prognosis and survival.Eur Rev Med Pharmacol Sci2017 AugLi WX-
29777904Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway.Biochim Biophys Acta Mol Basis Dis2018 AugJahan Rdoi: 10.1016/j.bbadis.2018.05.008
30293085MicroRNA-183-5p Inhibits Aggressiveness of Cervical Cancer Cells by Targeting Integrin Subunit Beta 1 (ITGB1).Med Sci Monit2018 Oct 7Zhang Wdoi: 10.12659/MSM.910295.
29511352Regulation of inside-out β1-integrin activation by CDCP1.Oncogene2018 MayPollan SGdoi: 10.1038/s41388-018-0142-2
27460703Basement membrane protein ladinin-1 and the MIF-CD44-β1 integrin signaling axis are implicated in laryngeal cancer metastasis.Biochim Biophys Acta2016 OctKlobuar Mdoi: 10.1016/j.bbadis.2016.07.014

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1032910284SilentnovelF701F0.25
BLCAchr1032929824Missense_MutationnovelS125L0.29
BLCAchr1032911998SilentNAV532V0.25
BLCAchr1032935526SilentNAL11L0.15
BLCAchr1032929861Missense_MutationNAQ113E0.3
BLCAchr1032925906Missense_MutationnovelG251S0.32
BLCAchr1032912081Missense_MutationNAD505H0.21
BRCAchr1032923701Missense_MutationNAF276L0.32
BRCAchr1032928257SilentNAP128P0.28
BRCAchr10329015413'UTRnovel0.21
BRCAchr1032929913SilentNAV95V0.35
BRCAchr1032926110Splice_SitenovelX183_splice0.15
BRCAchr1032928196Missense_MutationNAM149L0.28
BRCAchr1032910337Missense_MutationNAQ684E0.34
CESCchr1032908483Missense_MutationnovelG739A0.23
CESCchr1032911512Missense_MutationnovelP623A0.22
CESCchr1032929861Missense_MutationNAQ113E0.17
CESCchr10329006323'UTRnovel1
CESCchr10329003933'UTRnovel0.35
CESCchr1032912114Missense_MutationnovelG494R0.26
COADchr1032910381Missense_MutationNAN669I0.06
COADchr1032901588Silentrs201353781P793P0.39
COADchr1032908389Missense_MutationNAK770N0.35
COADchr1032920065Missense_MutationNAI430T0.15
COADchr1032929922SilentnovelN92N0.1
COADchr1032922288Missense_MutationNAN366S0.22
COADchr1032911953Missense_MutationNAI547M0.07
COADchr1032928153Missense_MutationNAK163T0.26
COADchr1032932533Silentrs200000349C45C0.33
COADchr1032928192Missense_MutationnovelD150G0.12
COADchr1032911649Missense_Mutationrs201856355R577H0.23
COADchr1032935542Missense_MutationNAI6S0.38
COADchr1032910255Missense_MutationNAN711S0.06
COADchr1032911603SilentNAC592C0.13
COADchr1032922723Missense_Mutationrs201869797I319V0.23
COADchr1032928169Missense_MutationNAD158N0.29
COADchr1032929886SilentnovelE104E0.22
COADchr1032920354Missense_MutationNAG387D0.24
COADchr1032929928Missense_MutationNAK90N0.16
COADchr1032908440In_Frame_InsnovelL753_L754insERT0.07
ESCAchr1032907116Intronnovel0.73
ESCAchr10329013773'UTRnovel0.26
ESCAchr1032925901Silentrs12261912F252F0.2
GBMchr1032911976Missense_MutationnovelK540E0.07
GBMchr1032907067Intronnovel0.16
GBMchr1032920045Missense_MutationnovelK437E0.06
GBMchr1032925901Silentrs12261912F252F0.19
GBMchr1032911597Missense_MutationnovelL594F0.08
GBMchr10329015663'UTRnovel0.21
GBMchr1032925927Missense_MutationnovelN244D0.04
HNSCchr1032928169Missense_MutationNAD158N0.33
HNSCchr1032920041Frame_Shift_DelNAK438Rfs*170.25
HNSCchr1032928169Missense_MutationNAD158N0.23
HNSCchr1032910253Missense_Mutationrs373574635E712K0.12
HNSCchr1032911581Missense_MutationnovelE600K0.16
HNSCchr1032907105Intronnovel0.29
HNSCchr1032919892Missense_Mutationrs749899655A488T0.11
HNSCchr1032910281Nonsense_MutationnovelY702*0.65
HNSCchr1032922272Missense_MutationnovelI371M0.19
HNSCchr1032922275Missense_MutationnovelL370F0.35
HNSCchr1032911503Nonsense_MutationNAQ626*0.17
HNSCchr1032911938SilentnovelF552F0.05
HNSCchr1032920039Missense_MutationnovelD439N0.36
HNSCchr1032928156Missense_MutationnovelV162G0.23
KICHchr1032929902Missense_MutationnovelS99N0.79
KIRCchr1032910387Missense_MutationNAY667C0.35
KIRCchr1032929854In_Frame_DelnovelD110_Q115del0.17
KIRCchr1032910325In_Frame_DelnovelD686_P687del0.22
KIRPchr1032912085Frame_Shift_DelnovelS503Rfs*640.45
KIRPchr1032910398SilentnovelQ663Q0.4
LGGchr1032910376Missense_MutationnovelT671A0.48
LGGchr1032911539Missense_Mutationrs140200196E614K0.31
LGGchr1032929843Silentrs764354170L119L0.13
LIHCchr1032928097Missense_MutationNAI182L0.08
LUADchr10329015603'UTRnovel0.31
LUADchr1032901585Missense_MutationnovelK794N0.13
LUADchr1032920356Silentrs199940049N386N0.25
LUADchr1032925912Missense_MutationnovelE249K0.06
LUADchr1032932566SilentnovelS34S0.08
LUADchr1032911490Missense_MutationNAC630Y0.15
LUADchr1032928188SilentNAL151L0.13
LUADchr1032923668Missense_MutationnovelD287N0.21
LUADchr1032925950Missense_MutationnovelV236A0.13
LUSCchr1032910295Missense_Mutationrs200536241D698N0.31
LUSCchr1032922328Missense_MutationnovelP353S0.26
LUSCchr1032907105Intronnovel0.05
LUSCchr1032908395Missense_MutationnovelK768N0.33
LUSCchr1032908369Missense_MutationNAT777M0.27
LUSCchr1032935544Silentrs780637452P5P0.09
LUSCchr1032910429Missense_MutationNAN653S0.32
LUSCchr1032928196Missense_MutationNAM149V0.16
LUSCchr1032920264Missense_Mutationrs372397463N417S0.4
LUSCchr1032919990Missense_MutationnovelE455V0.36
LUSCchr1032907134Intronnovel0.07
OVchr1032925969Missense_MutationnovelE230K0.13
OVchr1032907108Intronnovel0.14
OVchr1032907109Intronnovel0.14
OVchr1032920305Silentrs750454994N403N0.28
READchr1032920041Frame_Shift_DelNAK438Rfs*170.39
SKCMchr1032928194Missense_MutationNAM149I0.66
SKCMchr1032919979Nonsense_MutationnovelQ459*0.37
SKCMchr1032901626Missense_MutationNAP781S0.5
SKCMchr1032910422SilentnovelG655G0.66
SKCMchr1032929871SilentNAE109E0.28
SKCMchr1032912098Missense_MutationNAH499L0.78
SKCMchr1032901589Missense_MutationNAP793L0.11
SKCMchr1032907098Intronnovel0.13
SKCMchr1032919986In_Frame_DelnovelV454_V456del0.07
SKCMchr1032907086Intronrs1997441040.17
SKCMchr1032907087Intronnovel0.17
SKCMchr1032907109Intronnovel0.43
STADchr1032925869Splice_SiteNAX262_splice0.37
STADchr1032911657SilentNAC574C0.3
STADchr1032929906Missense_MutationNAR98C0.26
STADchr1032907132IntronNA0.3
STADchr1032920002Missense_Mutationrs201228879T451M0.16
STADchr1032908406Missense_MutationNAK765E0.26
STADchr1032920382Missense_MutationNAL378I0.19
STADchr1032912000Missense_Mutationrs202115007V532I0.27
STADchr1032920382Missense_MutationNAL378I0.18
STADchr1032920382Missense_MutationNAL378I0.32
STADchr1032920382Missense_MutationNAL378I0.09
STADchr1032925938Missense_Mutationrs371485643R240H0.14
STADchr1032920382Missense_MutationNAL378I0.39
THCAchr1032926076Missense_MutationNAP194R0.06
THCAchr1032911958Missense_MutationNAE546K0.16
UCECchr1032920040Missense_MutationNAK438N0.23
UCECchr10329008683'UTRnovel0.3
UCECchr1032910347SilentnovelP680P0.36
UCECchr1032920347SilentnovelL389L0.17
UCECchr10329012943'UTRnovel0.39
UCECchr1032928138Missense_MutationnovelD168G0.34
UCECchr1032908468Missense_MutationNAG744D0.46
UCECchr10329014533'UTRrs1996304930.47
UCECchr1032911539Missense_Mutationrs140200196E614K0.38
UCECchr10329008933'UTRnovel0.06
UCECchr1032907133Intronrs2006217850.27
UCECchr1032908370Missense_MutationnovelT777A0.36
UCECchr1032919906Missense_MutationnovelT483I0.57
UCECchr10329008733'UTRnovel0.15
UCECchr1032923598Missense_MutationNAM310T0.39
UCECchr1032911901Missense_MutationnovelG565C0.13
UCECchr1032925938Missense_Mutationrs371485643R240H0.19
UCECchr1032930010Frame_Shift_DelnovelR63Hfs*50.06
UCECchr1032925939Missense_Mutationrs144269881R240C0.15
UCECchr1032912001Silentrs149055349C531C0.38
UCECchr1032935493Splice_RegionnovelT22T0.14
UCECchr10329008683'UTRnovel0.24
UCECchr1032901588Silentrs201353781P793P0.41
UCECchr1032908442Missense_MutationnovelL753I0.41
UCECchr1032925933Missense_MutationNAS242T0.04
UCECchr1032919921Missense_MutationNAH478R0.48
UCECchr1032910296Missense_MutationnovelD697E0.13
UCECchr1032920020Missense_MutationNAI445N0.09
UCECchr1032907132IntronNA0.33
UCECchr1032908430Missense_MutationnovelI757L0.38
UCECchr1032929886Missense_MutationnovelE104D0.32
UCECchr10329013853'UTRnovel0.29
UCECchr1032911553Missense_MutationnovelG609D0.04
UCECchr10329005573'UTRnovel0.3
UCECchr1032929834Nonsense_MutationNAR122*0.27
UCECchr1032911539Missense_Mutationrs140200196E614K0.16
UCECchr1032925928SilentnovelG243G0.48
UCECchr1032928117Missense_MutationnovelR175K0.4
UCECchr10329008933'UTRnovel0.33
UCECchr1032907132IntronNA0.53
UCECchr1032912088SilentNAC502C0.34
UCECchr1032929928Missense_MutationNAK90N0.25
UCECchr1032910416Frame_Shift_InsnovelK658Efs*120.37
UCECchr10329004643'UTRnovel0.2
UCECchr10329009673'UTRnovel0.34
UCSchr1032911501Missense_MutationnovelQ626H0.17

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
BLCADEL0.13970.16614
STADAMP0.220.021867

Survival Analysis
CancerP-value Q-value
KIRC0.00089

Kaplan-Meier Survival Analysis

STAD0.018

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.0064

Kaplan-Meier Survival Analysis

SKCM0.046

Kaplan-Meier Survival Analysis

LUSC0.0013

Kaplan-Meier Survival Analysis

KIRP0.0087

Kaplan-Meier Survival Analysis

PAAD0.0035

Kaplan-Meier Survival Analysis

CESC0.0002

Kaplan-Meier Survival Analysis

LAML0.0059

Kaplan-Meier Survival Analysis

KICH0.031

Kaplan-Meier Survival Analysis

GBM0.028

Kaplan-Meier Survival Analysis

LIHC0.023

Kaplan-Meier Survival Analysis

LGG0.00013

Kaplan-Meier Survival Analysis

LUAD0.0007

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000150093 (Gene tree)
Gene ID
3688
Gene Symbol
ITGB1
Alias
CD29|GPIIA|FNRB|MSK12|MDF2
Full Name
integrin subunit beta 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
105,475 bases
Position
chr10:32,900,318-33,005,792
Accession
6153
RBP type
non-canonical RBP
Summary
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16917503Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.EMBO J2006 Sep 6Jung KK-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000472147ITGB1-209668-ENSP0000042041614 (aa)-C9JNE0
ENST00000439974ITGB1-207580--- (aa)--
ENST00000488427ITGB1-214861-ENSP0000041750870 (aa)-H7C4K3
ENST00000494395ITGB1-217562-ENSP00000417799108 (aa)-H7C4N8
ENST00000488494ITGB1-215540-ENSP00000418725152 (aa)-E7EUI6
ENST00000414670ITGB1-203500-ENSP0000040054449 (aa)-Q5T3E4
ENST00000528877ITGB1-218546-ENSP00000436214104 (aa)-E9PQJ2
ENST00000475184ITGB1-211552-ENSP00000417243124 (aa)-E7ERX5
ENST00000484088ITGB1-213580--- (aa)--
ENST00000437302ITGB1-206445-ENSP00000398029136 (aa)-Q5T3E6
ENST00000480226ITGB1-212585-ENSP00000417537163 (aa)-E7EQW5
ENST00000493758ITGB1-216366-ENSP0000042079231 (aa)-C9JJP8
ENST00000417122ITGB1-204569-ENSP0000040454689 (aa)-Q5T3E5
ENST00000474568ITGB1-210788-ENSP0000042028298 (aa)-C9JPK5
ENST00000534049ITGB1-219562-ENSP00000431326143 (aa)-E9PLR6
ENST00000396033ITGB1-2023784-ENSP00000379350798 (aa)-P05556
ENST00000423113ITGB1-2053729-ENSP00000388694801 (aa)-P05556
ENST00000464001ITGB1-208316--- (aa)--
ENST00000302278ITGB1-2013640-ENSP00000303351798 (aa)-P05556
Gene Model
Click here to download ENSG00000150093's gene model file
Pathways
Pathway IDPathway NameSource
hsa04015Rap1 signaling pathwayKEGG
hsa04145PhagosomeKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04360Axon guidanceKEGG
hsa04510Focal adhesionKEGG
hsa04512ECM-receptor interactionKEGG
hsa04514Cell adhesion molecules (CAMs)KEGG
hsa04530Tight junctionKEGG
hsa04611Platelet activationKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05100Bacterial invasion of epithelial cellsKEGG
hsa05130Pathogenic Escherichia coli infectionKEGG
hsa05131ShigellosisKEGG
hsa05133PertussisKEGG
hsa05140LeishmaniasisKEGG
hsa05145ToxoplasmosisKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05205Proteoglycans in cancerKEGG
hsa05222Small cell lung cancerKEGG
hsa05410Hypertrophic cardiomyopathy (HCM)KEGG
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGG
hsa05414Dilated cardiomyopathy (DCM)KEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000150093Cholesterol, LDL5.92e-00519060910
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000150093's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000150093ITGB199100.000ENSMUSG00000025809Itgb19995.495Mus_musculus
ENSG00000150093ITGB19747.664ENSMUSG00000000290Itgb29945.500Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000082G1/S transition of mitotic cell cycle-IEAProcess
GO:0001618virus receptor activity-IEAFunction
GO:0001701in utero embryonic development-IEAProcess
GO:0001708cell fate specification-IEAProcess
GO:0001726ruffle11919189.TASComponent
GO:0001968fibronectin binding21873635.IBAFunction
GO:0001968fibronectin binding11792823.IPIFunction
GO:0002020protease binding10455171.IPIFunction
GO:0002042cell migration involved in sprouting angiogenesis-IEAProcess
GO:0003779actin binding16803572.IDAFunction
GO:0005178integrin binding21873635.IBAFunction
GO:0005515protein binding1542691.9281591.9360996.9722563.10397731.10676904.11279249.11807099.12473654.12592401.12695522.12724312.12796480.12807887.14681217.14970227.15703214.16076904.16099422.16754661.16754960.16803572.17158881.17690686.17704059.17925226.18177638.19168626.19268462.20159608.20183869.20802515.20802519.21134644.21397862.21806020.21947080.22178926.22940691.24789099.25661773.30021884.IPIFunction
GO:0005737cytoplasm16803572.IDAComponent
GO:0005886plasma membrane12869515.16803572.21310825.IDAComponent
GO:0005886plasma membrane10455171.NASComponent
GO:0005886plasma membrane-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion21873635.IBAComponent
GO:0005925focal adhesion12417594.17158881.23023225.29162887.IDAComponent
GO:0005925focal adhesion14970227.IDAComponent
GO:0006909phagocytosis-ISSProcess
GO:0006968cellular defense response10201960.TASProcess
GO:0007155cell adhesion19703720.IDAProcess
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules10201960.TASProcess
GO:0007159leukocyte cell-cell adhesion1715889.IDAProcess
GO:0007160cell-matrix adhesion21873635.IBAProcess
GO:0007160cell-matrix adhesion18156211.18308860.24823363.IMPProcess
GO:0007161calcium-independent cell-matrix adhesion19651211.IGIProcess
GO:0007179transforming growth factor beta receptor signaling pathway24036928.IMPProcess
GO:0007229integrin-mediated signaling pathway21873635.IBAProcess
GO:0007229integrin-mediated signaling pathway24823363.IMPProcess
GO:0008284positive regulation of cell proliferation-IEAProcess
GO:0008305integrin complex21873635.IBAComponent
GO:0008305integrin complex9552005.NASComponent
GO:0008354germ cell migration-IEAProcess
GO:0008542visual learning-IEAProcess
GO:0009897external side of plasma membrane-IEAComponent
GO:0009986cell surface19581412.23382103.23658023.23981064.HDAComponent
GO:0009986cell surface21873635.IBAComponent
GO:0009986cell surface1715889.17158881.19234460.19933311.20563599.21310825.23023225.23154389.23620790.24036928.25063885.IDAComponent
GO:0010710regulation of collagen catabolic process10455171.IDAProcess
GO:0014704intercalated disc-IEAComponent
GO:0015026coreceptor activity23125415.TASFunction
GO:0016020membrane19946888.HDAComponent
GO:0016477cell migration21873635.IBAProcess
GO:0016477cell migration11919189.TASProcess
GO:0019221cytokine-mediated signaling pathway-TASProcess
GO:0019960C-X3-C chemokine binding21873635.IBAFunction
GO:0019960C-X3-C chemokine binding23125415.IDAFunction
GO:0021943formation of radial glial scaffolds-IEAProcess
GO:0030027lamellipodium-IEAComponent
GO:0030030cell projection organization-ISSProcess
GO:0030032lamellipodium assembly-ISSProcess
GO:0030175filopodium16803572.IDAComponent
GO:0030183B cell differentiation1715889.ICProcess
GO:0030198extracellular matrix organization-TASProcess
GO:0031589cell-substrate adhesion19933311.IMPProcess
GO:0031594neuromuscular junction9415431.IDAComponent
GO:0031623receptor internalization-ISSProcess
GO:0032154cleavage furrow-IEAComponent
GO:0032587ruffle membrane14970227.IDAComponent
GO:0032587ruffle membrane10455171.NASComponent
GO:0033627cell adhesion mediated by integrin21873635.IBAProcess
GO:0033627cell adhesion mediated by integrin12807887.17158881.IDAProcess
GO:0033627cell adhesion mediated by integrin-ISSProcess
GO:0033631cell-cell adhesion mediated by integrin17704059.IEPProcess
GO:0034113heterotypic cell-cell adhesion20563599.IMPProcess
GO:0034665integrin alpha1-beta1 complex24823363.IDAComponent
GO:0034666integrin alpha2-beta1 complex24823363.IDAComponent
GO:0034667integrin alpha3-beta1 complex24220332.25063885.IDAComponent
GO:0034677integrin alpha7-beta1 complex-IEAComponent
GO:0034678integrin alpha8-beta1 complex21335239.TASComponent
GO:0034680integrin alpha10-beta1 complex24823363.IDAComponent
GO:0034681integrin alpha11-beta1 complex24823363.IDAComponent
GO:0035024negative regulation of Rho protein signal transduction-IEAProcess
GO:0035748myelin sheath abaxonal region-IEAComponent
GO:0042383sarcolemma9415431.IDAComponent
GO:0042470melanosome-IEAComponent
GO:0043065positive regulation of apoptotic process19364818.IGIProcess
GO:0043149stress fiber assembly24036928.IMPProcess
GO:0043197dendritic spine-IEAComponent
GO:0043235receptor complex23382219.IDAComponent
GO:0043236laminin binding21873635.IBAFunction
GO:0043547positive regulation of GTPase activity25911094.IMPProcess
GO:0044877protein-containing complex binding25336636.IPIFunction
GO:0045121membrane raft14559243.IDAComponent
GO:0045214sarcomere organization-IEAProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0045596negative regulation of cell differentiation-IEAProcess
GO:0045766positive regulation of angiogenesis24044949.IMPProcess
GO:0046718viral entry into host cell-IEAProcess
GO:0046872metal ion binding-IEAFunction
GO:0046982protein heterodimerization activity10455171.IDAFunction
GO:0046982protein heterodimerization activity9552005.NASFunction
GO:0048333mesodermal cell differentiation23154389.IEPProcess
GO:0048471perinuclear region of cytoplasm20183869.IDAComponent
GO:0048675axon extension-IEAProcess
GO:0048813dendrite morphogenesis-IEAProcess
GO:0050776regulation of immune response-TASProcess
GO:0050804modulation of chemical synaptic transmission-IEAProcess
GO:0050839cell adhesion molecule binding12869515.IPIFunction
GO:0050900leukocyte migration-TASProcess
GO:0050901leukocyte tethering or rolling18308860.IMPProcess
GO:0051726regulation of cell cycle-IEAProcess
GO:0051897positive regulation of protein kinase B signaling24044949.IDAProcess
GO:0055007cardiac muscle cell differentiation-IEAProcess
GO:0055037recycling endosome-IEAComponent
GO:0070062extracellular exosome19056867.23533145.HDAComponent
GO:0071404cellular response to low-density lipoprotein particle stimulus-ISSProcess
GO:0071438invadopodium membrane10455171.IDAComponent
GO:0071711basement membrane organization-IEAProcess
GO:0097386glial cell projection-ISSComponent
GO:0098639collagen binding involved in cell-matrix adhesion21873635.IBAFunction
GO:0098639collagen binding involved in cell-matrix adhesion24823363.IMPFunction
GO:0098685Schaffer collateral - CA1 synapse-IEAComponent
GO:0098978glutamatergic synapse-IEAComponent
GO:0099699integral component of synaptic membrane-IEAComponent
GO:1903078positive regulation of protein localization to plasma membrane10455171.IDAProcess
GO:2000273positive regulation of signaling receptor activity24044949.IDAProcess
GO:2000811negative regulation of anoikis15006356.IMPProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us