EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24659669MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog.J BUON2014 Jan-MarLi L-
23824073Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis.Acta Biochim Biophys Sin (Shanghai)2013 SepLiu Sdoi: 10.1093/abbs/gmt075
22267128Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes' stage of colorectal cancer patients.Oncol Rep2012 MayHoriuchi Adoi: 10.3892/or.2012.1648
19682430MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells.Biochem Biophys Res Commun2009 Oct 23Yao Qdoi: 10.1016/j.bbrc.2009.08.044
26864640MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4.Cancer Med2016 AprWei Xdoi: 10.1002/cam4.626
22335905[Overexpression of miR-21 promotes proliferation and reduces apoptosis in non-small cell lung cancer].Zhonghua Zhong Liu Za Zhi2011 OctLan H-
30243936The mechanisms and clinical significance of PDCD4 in colorectal cancer.Gene2019 Jan 5Long Jdoi: 10.1016/j.gene.2018.09.034
30496290A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability.PLoS Genet2018 Nov 29Jadaliha Mdoi: 10.1371/journal.pgen.1007802
24764298Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability.J Biol Chem2014 Jun 20Fay MMdoi: 10.1074/jbc.M113.541300
17828298Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells.Oncogene2008 Mar 6Wang Q-
25573956Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells.Mol Cancer Ther2015 MarZhang Ydoi: 10.1158/1535-7163.MCT-14-0648
17955371The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells.Apoptosis2008 JanLankat-Buttgereit B-
26871813Hypermethylation and Expression Silencing of PDCD4 Gene in Hepatocellular Carcinoma: A Consort Study.Medicine (Baltimore)2016 FebDing Xdoi: 10.1097/MD.0000000000002729.
22761399Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells.Mol Cell Proteomics2012 OctSudhir PR-
18296647Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion.Cancer Res2008 Mar 1Schmid Tdoi: 10.1158/0008-5472.CAN-07-1719
22203471Down-regulation of PDCD4 expression is an independent predictor of poor prognosis in human renal cell carcinoma patients.J Cancer Res Clin Oncol2012 MarLi Xdoi: 10.1007/s00432-011-1121-y
22728051Role of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas.Fertil Steril2012 SepFitzgerald JBdoi: 10.1016/j.fertnstert.2012.05.040
19672202Cholesteatoma growth and proliferation: posttranscriptional regulation by microRNA-21.Otol Neurotol2009 OctFriedland DRdoi: 10.1097/MAO.0b013e3181b4e91f.
21781452LOH at PDCD4, CTNNB1, and CASP4 loci contributes to stage progression of oral cancer.Int J Immunopathol Pharmacol2011 Apr-JunScapoli L-
25979949Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.Blood2015 Aug 20Junker Fdoi: 10.1182/blood-2014-12-618892
18372920MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene.Oncogene2008 Jul 17Lu Zdoi: 10.1038/onc.2008.72
16682950Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma.Oncogene2006 Oct 5Zhang H-
24157866Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma.Cell Death Dis2013 Oct 24Zhen Ydoi: 10.1038/cddis.2013.376.
21983937Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma.Mod Pathol2012 JanNagao Ydoi: 10.1038/modpathol.2011.142
16449643Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.Mol Cell Biol2006 FebYang HS-
25175929miR-21 increases the programmed cell death 4 gene-regulated cell proliferation in head and neck squamous carcinoma cell lines.Oncol Rep2014 NovSun Zdoi: 10.3892/or.2014.3456
27430936Ubiquitin-specific protease 4 inhibits breast cancer cell growth through the upregulation of PDCD4.Int J Mol Med2016 SepLi Ydoi: 10.3892/ijmm.2016.2685
22431522Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.Mol Cell Biol2012 MayLiwak Udoi: 10.1128/MCB.06317-11
27852288The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis.Chin J Cancer2016 Nov 16Li JZ-
26367487miR-21 regulates tumor progression through the miR-21-PDCD4-Stat3 pathway in human salivary adenoid cystic carcinoma.Lab Invest2015 DecJiang LHdoi: 10.1038/labinvest.2015.105
18427550siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression.Oncogene2008 Aug 14Bitomsky Ndoi: 10.1038/onc.2008.115
28853972Programmed cell death 4 mechanism of action: The model to be updated?Cell Cycle2017 Oct 2Vikhreva PNdoi: 10.1080/15384101.2017.1371881
29331036Prognostic significance of miR-21 and PDCD4 in patients with stage II esophageal carcinoma after surgical resection.J Cell Biochem2018 JunZhang Jdoi: 10.1002/jcb.26672
20498644Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion.Oncogene2010 Jul 8Santhanam ANdoi: 10.1038/onc.2010.158
19728867Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer.Mol Cancer2009 Sep 3Wei NAdoi: 10.1186/1476-4598-8-70.
26026468Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer.Breast Cancer Res Treat2015 JulChen Zdoi: 10.1007/s10549-015-3446-8
27647131miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4.Protein Cell2016 OctLiu Y-
28692058Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.Oncogene2017 Nov 9Wang Qdoi: 10.1038/onc.2017.228
28981115miR-23a/b promote tumor growth and suppress apoptosis by targeting PDCD4 in gastric cancer.Cell Death Dis2017 Oct 5Hu Xdoi: 10.1038/cddis.2017.447.
23888942Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21.Curr Pharm Des2014Tu H-
20595005Programmed cell death 4 (PDCD4) mediates the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by down-regulation of FLIP expression.Exp Cell Res2010 Sep 10Wang Wdoi: 10.1016/j.yexcr.2010.05.027
27035745Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer.Int J Oncol2016 JunLiao Jdoi: 10.3892/ijo.2016.3453
24865582Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway.PLoS One2014 May 27Echevarr??a-Vargas IMdoi: 10.1371/journal.pone.0097094
26252635IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate Cancer.PLoS One2015 Aug 7Dong Bdoi: 10.1371/journal.pone.0134366
20372781Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer.Int J Oncol2010 MayMotoyama K-
25012722MicroRNA-182 modulates chemosensitivity of human non-small cell lung cancer to cisplatin by targeting PDCD4.Diagn Pathol2014 Jul 10Ning FLdoi: 10.1186/1746-1596-9-143.
17991735Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.J Biol Chem2008 Jan 11Frankel LB-
25144746Helicobacter pylori promotes epithelial-mesenchymal transition in gastric cancer by downregulating programmed cell death protein 4 (PDCD4).PLoS One2014 Aug 21Yu Hdoi: 10.1371/journal.pone.0105306
23296900MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas.J Cell Biochem2013 JulWang YQdoi: 10.1002/jcb.24488.
22419096Protein kinase GSK3β regulates tumor suppressor Pdcd4 expression in lung cancer cells.Dokl Biochem Biophys2012 Jan-FebVikhreva PNdoi: 10.1134/S1607672912010176
24334141mTOR-dependent transcriptional repression of Pdcd4 tumor suppressor in lung cancer cells.Biochim Biophys Acta2014 JanVikhreva PNdoi: 10.1016/j.bbagrm.2013.12.001
23314309PDCD4 functions as a suppressor for pT2a and pT2b stage gastric cancer.Oncol Rep2013 MarGuo PTdoi: 10.3892/or.2013.2232
27021515miR-93 functions as an oncomiR for the downregulation of PDCD4 in gastric carcinoma.Sci Rep2016 Mar 29Liang Hdoi: 10.1038/srep23772.
18386173Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression.Breast Cancer Res Treat2009 MarNieves-Alicea Rdoi: 10.1007/s10549-008-9993-5
17849461Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer.Cancer2007 Oct 15Mudduluru G-
26961483MicroRNA-183 Functions As an Oncogene by Regulating PDCD4 in Gastric Cancer.Anticancer Agents Med Chem2016Li C-
18457901Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors.Lung Cancer2008 NovKalinichenko SVdoi: 10.1016/j.lungcan.2008.03.022
20560677Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway.Mol Diagn Ther2010 Jun 1Wang WQdoi: 10.2165/11536340-000000000-00000.
19836969Pdcd4, a colon cancer prognostic that is regulated by a microRNA.Crit Rev Oncol Hematol2010 MarAllgayer Hdoi: 10.1016/j.critrevonc.2009.09.001
19493270PDCD4 inhibits the malignant phenotype of ovarian cancer cells.Cancer Sci2009 AugWei ZTdoi: 10.1111/j.1349-7006.2009.01210.x
26802652Reduced PDCD4 Expression Promotes Cell Growth Through PI3K/Akt Signaling in Non-Small Cell Lung Cancer.Oncol Res2016Zhen Ydoi: 10.3727/096504015X14478843952861.
24568503PDCD4 as a predictor of sensitivity to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.Asian Pac J Cancer Prev2014Dou X-
23564788Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol.Anticancer Res2013 AprPaik WH-
25776494miR-183 induces cell proliferation, migration, and invasion by regulating PDCD4 expression in the SW1990 pancreatic cancer cell line.Biomed Pharmacother2015 MarLu YYdoi: 10.1016/j.biopha.2015.01.016
26212010Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis.Oncogene2016 Apr 28Venturutti Ldoi: 10.1038/onc.2015.281
29091952Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study.PLoS One2017 Nov 1Fawzy MSdoi: 10.1371/journal.pone.0187310
27542230PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation.Oncotarget2016 Sep 13Jo SHdoi: 10.18632/oncotarget.11227.
27634902miR-208a-3p suppresses cell apoptosis by targeting PDCD4 in gastric cancer.Oncotarget2016 Oct 11Yin Kdoi: 10.18632/oncotarget.12006.
28842954MiR-155 inhibits proliferation and invasion by directly targeting PDCD4 in non-small cell lung cancer.Thorac Cancer2017 NovLiu Fdoi: 10.1111/1759-7714.12492
29091902MicroRNA-150 promotes cell proliferation, migration, and invasion of cervical cancer through targeting PDCD4.Biomed Pharmacother2018 JanZhang Zdoi: 10.1016/j.biopha.2017.09.143
28477403Micro-RNA-21 Regulates Cancer-Associated Fibroblast-Mediated Drug Resistance in Pancreatic Cancer.Oncol Res2018 Jul 5Zhang Ldoi: 10.3727/096504017X14934840662335
30365117MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation.Int J Mol Med2019 JanWang Ydoi: 10.3892/ijmm.2018.3932

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr10110881531Missense_MutationNAK114N0.18
BLCAchr10110881322Missense_MutationNAI45V0.21
BLCAchr10110885255Missense_MutationnovelE148D0.44
BLCAchr10110881389Missense_MutationnovelS67L0.23
BLCAchr10110881497Missense_MutationNAR103Q0.27
BLCAchr10110887692Missense_MutationnovelE195K0.41MA3
BLCAchr10110890640SilentNAG320G0.43
BLCAchr10110894178Missense_MutationnovelH360N0.16
BLCAchr10110876716Intronrs5502871300.36
BRCAchr10110885310Missense_MutationnovelT167P0.08MA3
BRCAchr10110876035Missense_MutationnovelV3A0.03
BRCAchr10110890603Missense_MutationNAG308A0.17
BRCAchr10110881231Splice_SitenovelX15_splice0.1
BRCAchr10110889540Missense_MutationnovelG262V0.08
BRCAchr10110895969Frame_Shift_DelNAE411Kfs*200.37
BRCAchr10110894516Missense_MutationnovelM401I0.08
CESCchr10110881439Missense_Mutationrs375978756A84T0.41
CESCchr10110883012Missense_MutationNAG119A0.12
CESCchr10110881318SilentnovelN43N0.07
CESCchr10110881439Missense_Mutationrs375978756A84T0.17
CESCchr10110890568Missense_MutationNAD296E0.18
COADchr101108981053'UTRnovel0.4
COADchr10110876754Intronnovel0.22
COADchr10110895947Splice_SitenovelX404_splice0.42
COADchr10110896086Splice_RegionnovelR450R0.36
COADchr10110881526Missense_MutationNAP113S0.24
COADchr10110881497Missense_MutationNAR103Q0.29
COADchr10110885309Missense_MutationNAK166N0.24MA3
COADchr10110881385Frame_Shift_InsnovelN66Rfs*260.07
COADchr10110881387Missense_MutationnovelN66K0.07
COADchr10110885344Missense_MutationNAH178R0.31MA3
DLBCchr10110876671Intronnovel0.13
ESCAchr10110898065Missense_Mutationrs185959051R463C0.2
ESCAchr10110889540Missense_MutationnovelG262V0.36
GBMchr10110881252Frame_Shift_DelnovelL23Ffs*130.66
GBMchr10110895950Splice_RegionNAG404G0.12
HNSCchr10110881438Silentrs538533354D83D0.2
HNSCchr10110887877Missense_MutationnovelR256S0.33
KIRCchr10110876060SilentnovelV11V0.09
KIRCchr101108982093'UTRnovel0.14
KIRPchr10110876692Intronnovel0.86
KIRPchr10110896061SilentNAK441K0.31
KIRPchr10110898039Missense_MutationnovelR454L0.06
LAMLchr10110887818Frame_Shift_InsnovelS239Ifs*30.09
LGGchr10110881266Missense_Mutationrs772371476G26D0.17
LGGchr10110881484Missense_MutationnovelL99M0.36
LGGchr10110885252Splice_SitenovelX148_splice0.35
LGGchr10110887739Missense_MutationnovelE210D0.33MA3
LGGchr101108981283'UTRnovel0.38
LUADchr10110881519Missense_MutationNAR110S0.3
LUADchr10110894194Missense_Mutationrs756635108Y365F0.93
LUADchr101108759895'UTRnovel0.37
LUADchr10110881424Missense_MutationnovelD79Y0.39
LUADchr10110895997Missense_MutationnovelP420L0.21
LUSCchr10110894111Silentrs147334980E337E0.13
LUSCchr10110889532Splice_SitenovelX260_splice0.21
LUSCchr10110896061Frame_Shift_DelnovelQ442Tfs*230.1
LUSCchr10110895969Missense_MutationnovelE411K0.26
OVchr10110881417SilentNAS76S0.38
PAADchr10110889584Missense_MutationnovelT277A0.31
READchr10110881343Missense_Mutationrs754525539E52K0.3
READchr10110898040SilentnovelR454R0.09
READchr10110896071Missense_MutationnovelD445Y0.38
READchr10110894171Silentrs185605824P357P0.15
READchr10110887845Missense_MutationNAD246Y0.46
SARCchr10110894136Nonsense_MutationnovelE346*0.17
SKCMchr10110895975Missense_MutationNAP413S0.38
SKCMchr101108759835'UTRnovel0.33
SKCMchr10110885252Splice_SiteNAX148_splice0.27
SKCMchr10110881340Missense_MutationNAN51D0.12
SKCMchr10110876064Missense_MutationNAP13S0.27
SKCMchr10110883077Missense_MutationNAP141S0.46
SKCMchr10110881251Missense_MutationNAD21G0.25
SKCMchr101108759785'UTRnovel0.31
STADchr10110887833Missense_MutationNAK242E0.14
STADchr10110876055Missense_MutationnovelN10D0.07
STADchr10110881438Silentrs538533354D83D0.38
STADchr10110881361Missense_MutationNAK58E0.07
STADchr10110881358Missense_MutationNAA57T0.09
STADchr10110887713Missense_MutationNAV202M0.16MA3
THCAchr10110889615Missense_MutationNAD287G0.18
UCECchr10110895950Splice_RegionnovelG404G0.06
UCECchr101108985633'UTRnovel0.42
UCECchr10110881395Missense_Mutationrs184353935R69Q0.16
UCECchr10110894109Nonsense_MutationNAE337*0.23
UCECchr10110881300Missense_MutationNAK37N0.26
UCECchr10110883058Missense_MutationnovelE134D0.2
UCECchr10110887805SilentnovelS232S0.24
UCECchr10110890578Missense_Mutationrs367566735V300M0.16
UCECchr10110881357SilentnovelN56N0.22
UCECchr10110875963Splice_Regionnovel0.47
UCECchr10110881383Missense_MutationnovelK65T0.32
UCECchr101108982373'UTRnovel0.47
UCECchr101108984673'UTRnovel0.11
UCECchr10110896032Nonsense_MutationnovelE432*0.42
UCECchr10110895958Missense_MutationNAR407I0.38
UCECchr10110887845Missense_MutationNAD246Y0.45
UCECchr101108985403'UTRnovel0.35
UCECchr10110894109Nonsense_MutationNAE337*0.21
UCECchr10110894199Splice_SitenovelX366_splice0.47
UCECchr101108985633'UTRnovel0.55
UCECchr10110881285SilentNAG32G0.19
UCECchr101108719175'UTRnovel0.27
UCECchr10110885261SilentNAC150C0.4
UCECchr101108760265'UTRnovel0.31
UCECchr10110898051Missense_MutationNAE458G0.33
UCECchr10110889625Missense_MutationNAQ290H0.26
UCECchr101108985633'UTRnovel0.23
UCECchr101108982903'UTRnovel0.29
UCSchr10110890566Missense_MutationnovelD296Y0.13

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
CHOLDEL0.250.048655
COADDEL0.15969.4741e-07
LIHCDEL0.24055.7505e-06
MESODEL0.29890.00015289
OVDEL0.32995.3759e-12
PAADDEL0.11410.169
READDEL0.22420.014135
THYMDEL0.03250.10563
UCSDEL0.32140.1218

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.0016

Kaplan-Meier Survival Analysis

SKCM0.0028

Kaplan-Meier Survival Analysis

BRCA0.00016

Kaplan-Meier Survival Analysis

LAML0.0083

Kaplan-Meier Survival Analysis

UCEC0.016

Kaplan-Meier Survival Analysis

LGG0.00013

Kaplan-Meier Survival Analysis

THCA0.04

Kaplan-Meier Survival Analysis

LUAD0.017

Kaplan-Meier Survival Analysis

UVM0.007

Kaplan-Meier Survival Analysis

OV0.026

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000150593 (Gene tree)
Gene ID
27250
Gene Symbol
PDCD4
Alias
H731
Full Name
programmed cell death 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
28,212 bases
Position
chr10:110,871,795-110,900,006
Accession
8763
RBP type
canonical RBP
Summary
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000376816MA3PF02847.178.2e-4712
ENSP00000376816MA3PF02847.178.2e-4722
ENSP00000280154MA3PF02847.178.9e-4712
ENSP00000280154MA3PF02847.178.9e-4722
ENSP00000394668MA3PF02847.171.1e-1011
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12894233The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA.Oncogene2003 Jul 31Bohm M-
21779451Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions.Genes Cancer2010 MarWedeken Ldoi: 10.1177/1947601910364227.
27454120Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet.PLoS One2016 Jul 25Bai Ydoi: 10.1371/journal.pone.0159568
15661843Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.RNA2005 MarZakowicz H-
21643008Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation.Oncogene2011 Dec 8Singh Pdoi: 10.1038/onc.2011.202
24681950A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation.Oncogene2015 Mar 12Biyanee Adoi: 10.1038/onc.2014.83
18296639PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.Proc Natl Acad Sci U S A2008 Mar 4Suzuki Cdoi: 10.1073/pnas.0712235105
21273303A microRNA expression signature of osteoclastogenesis.Blood2011 Mar 31Sugatani Tdoi: 10.1182/blood-2010-10-311415
25519906Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).J Biol Chem2015 Feb 6Wigington CPdoi: 10.1074/jbc.M114.631937
25190455An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.Nucleic Acids Res2014Fehler Odoi: 10.1093/nar/gku800
26595526ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.Oncotarget2016 Jan 12Liwak-Muir Udoi: 10.18632/oncotarget.6363.
26189797RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4.Oncogene2016 Mar 31Poria DKdoi: 10.1038/onc.2015.235
25820028Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA.Biochim Biophys Acta2015 JulOhnheiser Jdoi: 10.1016/j.bbamcr.2015.03.008
19204291Crystal structure of the eIF4A-PDCD4 complex.Proc Natl Acad Sci U S A2009 Mar 3Chang JHdoi: 10.1073/pnas.0808275106
24041411The unique evolution of the programmed cell death 4 protein in plants.BMC Evol Biol2013 Sep 16Cheng Sdoi: 10.1186/1471-2148-13-199.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000467574PDCD4-205735--- (aa)--
ENST00000489049PDCD4-209547--- (aa)--
ENST00000483595PDCD4-207531--- (aa)--
ENST00000498367PDCD4-211975--- (aa)--
ENST00000481353PDCD4-2061120--- (aa)--
ENST00000462577PDCD4-204789--- (aa)--
ENST00000492932PDCD4-210813--- (aa)--
ENST00000444997PDCD4-203819-ENSP00000394668231 (aa)-Q5VZS7
ENST00000280154PDCD4-2013602-ENSP00000280154469 (aa)-Q53EL6
ENST00000483670PDCD4-208774--- (aa)--
ENST00000393104PDCD4-2023697-ENSP00000376816458 (aa)-Q53EL6
Gene Model
Click here to download ENSG00000150593's gene model file
Pathways
Pathway IDPathway NameSource
hsa05205Proteoglycans in cancerKEGG
hsa05206MicroRNAs in cancerKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000150593's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000150593PDCD49959.081ENSAPOG00000018171pdcd4a9960.497Acanthochromis_polyacanthus
ENSG00000150593PDCD49969.432ENSAPOG00000011195pdcd4b10068.211Acanthochromis_polyacanthus
ENSG00000150593PDCD410097.447ENSAMEG00000015646PDCD410097.447Ailuropoda_melanoleuca
ENSG00000150593PDCD49361.021ENSACIG00000020573pdcd4a9461.021Amphilophus_citrinellus
ENSG00000150593PDCD49969.869ENSACIG00000016432pdcd4b9969.330Amphilophus_citrinellus
ENSG00000150593PDCD49969.651ENSAOCG00000018427pdcd4b10068.421Amphiprion_ocellaris
ENSG00000150593PDCD49958.209ENSAOCG00000005375pdcd4a9859.856Amphiprion_ocellaris
ENSG00000150593PDCD49969.651ENSAPEG00000005735pdcd4b10068.421Amphiprion_percula
ENSG00000150593PDCD49958.862ENSAPEG00000015119pdcd4a9958.209Amphiprion_percula
ENSG00000150593PDCD49966.883ENSATEG00000008734pdcd4b9966.883Anabas_testudineus
ENSG00000150593PDCD49361.253ENSATEG00000016227pdcd4a9161.253Anabas_testudineus
ENSG00000150593PDCD49987.417ENSAPLG00000003137PDCD410085.501Anas_platyrhynchos
ENSG00000150593PDCD49161.005ENSACAG00000000420-9661.005Anolis_carolinensis
ENSG00000150593PDCD49985.430ENSACAG00000015761PDCD410084.222Anolis_carolinensis
ENSG00000150593PDCD410098.507ENSANAG00000031719PDCD410098.507Aotus_nancymaae
ENSG00000150593PDCD49969.869ENSACLG00000025687pdcd4b10068.632Astatotilapia_calliptera
ENSG00000150593PDCD49360.789ENSACLG00000021040pdcd4a9360.789Astatotilapia_calliptera
ENSG00000150593PDCD49362.037ENSAMXG00000030253pdcd4a9460.444Astyanax_mexicanus
ENSG00000150593PDCD410069.703ENSAMXG00000004515pdcd4b10069.703Astyanax_mexicanus
ENSG00000150593PDCD410096.588ENSBTAG00000019434PDCD410096.588Bos_taurus
ENSG00000150593PDCD410098.294ENSCJAG00000018795PDCD410098.294Callithrix_jacchus
ENSG00000150593PDCD410098.089ENSCAFG00000010807PDCD410098.089Canis_familiaris
ENSG00000150593PDCD410098.507ENSCAFG00020011940PDCD410098.507Canis_lupus_dingo
ENSG00000150593PDCD410097.015ENSCHIG00000022248PDCD410097.015Capra_hircus
ENSG00000150593PDCD410098.721ENSTSYG00000014536PDCD410098.721Carlito_syrichta
ENSG00000150593PDCD49985.153ENSCAPG00000014937PDCD49984.881Cavia_aperea
ENSG00000150593PDCD410095.522ENSCPOG00000007956PDCD410095.522Cavia_porcellus
ENSG00000150593PDCD410098.507ENSCCAG00000031181PDCD410098.507Cebus_capucinus
ENSG00000150593PDCD410098.253ENSCATG00000034630PDCD410098.253Cercocebus_atys
ENSG00000150593PDCD410096.375ENSCLAG00000001136PDCD410096.375Chinchilla_lanigera
ENSG00000150593PDCD410098.294ENSCSAG00000005152PDCD410098.294Chlorocebus_sabaeus
ENSG00000150593PDCD410091.429ENSCHOG00000007638PDCD410082.729Choloepus_hoffmanni
ENSG00000150593PDCD410087.846ENSCPBG00000012844PDCD410087.846Chrysemys_picta_bellii
ENSG00000150593PDCD49858.222ENSCPBG00000024450-9458.222Chrysemys_picta_bellii
ENSG00000150593PDCD49441.475ENSCING00000013216-9141.190Ciona_intestinalis
ENSG00000150593PDCD49340.659ENSCSAVG00000005003-9740.393Ciona_savignyi
ENSG00000150593PDCD410098.908ENSCANG00000027874PDCD410098.908Colobus_angolensis_palliatus
ENSG00000150593PDCD410096.802ENSCGRG00001007322Pdcd410096.802Cricetulus_griseus_chok1gshd
ENSG00000150593PDCD410096.802ENSCGRG00000017491Pdcd410096.802Cricetulus_griseus_crigri
ENSG00000150593PDCD49867.991ENSCSEG00000012126pdcd4b9966.951Cynoglossus_semilaevis
ENSG00000150593PDCD49958.952ENSCSEG00000002907pdcd4a9659.170Cynoglossus_semilaevis
ENSG00000150593PDCD49359.861ENSCVAG00000003035pdcd4a9159.861Cyprinodon_variegatus
ENSG00000150593PDCD49868.352ENSCVAG00000021740pdcd4b9967.019Cyprinodon_variegatus
ENSG00000150593PDCD49970.769ENSDARG00000041022pdcd4b10069.492Danio_rerio
ENSG00000150593PDCD49959.914ENSDARG00000021702pdcd4a9859.914Danio_rerio
ENSG00000150593PDCD410097.021ENSDNOG00000009494PDCD410097.021Dasypus_novemcinctus
ENSG00000150593PDCD410097.868ENSDORG00000002615Pdcd410097.868Dipodomys_ordii
ENSG00000150593PDCD47541.379FBgn0030520Pdcd48939.520Drosophila_melanogaster
ENSG00000150593PDCD410089.339ENSETEG00000013056PDCD410089.339Echinops_telfairi
ENSG00000150593PDCD49555.329ENSEBUG00000009505pdcd4a9855.329Eptatretus_burgeri
ENSG00000150593PDCD410097.868ENSEASG00005014903PDCD410097.868Equus_asinus_asinus
ENSG00000150593PDCD410097.868ENSECAG00000020935PDCD410097.868Equus_caballus
ENSG00000150593PDCD46284.507ENSEEUG00000011674-6184.507Erinaceus_europaeus
ENSG00000150593PDCD49971.957ENSELUG00000022960pdcd4b9971.550Esox_lucius
ENSG00000150593PDCD49759.649ENSELUG00000024343pdcd4a9861.036Esox_lucius
ENSG00000150593PDCD410097.655ENSFCAG00000011894PDCD410097.655Felis_catus
ENSG00000150593PDCD49987.638ENSFALG00000002279PDCD410085.714Ficedula_albicollis
ENSG00000150593PDCD410096.162ENSFDAG00000000911PDCD410096.162Fukomys_damarensis
ENSG00000150593PDCD49657.919ENSFHEG00000021625pdcd4a9358.145Fundulus_heteroclitus
ENSG00000150593PDCD49969.063ENSFHEG00000013043pdcd4b9768.000Fundulus_heteroclitus
ENSG00000150593PDCD49759.556ENSGMOG00000017926pdcd4a9759.778Gadus_morhua
ENSG00000150593PDCD49968.980ENSGMOG00000014693pdcd4b10067.925Gadus_morhua
ENSG00000150593PDCD49987.638ENSGALG00000008700PDCD410085.075Gallus_gallus
ENSG00000150593PDCD48255.990ENSGALG00000049949-7058.172Gallus_gallus
ENSG00000150593PDCD49359.629ENSGAFG00000005779pdcd4a9159.629Gambusia_affinis
ENSG00000150593PDCD49869.737ENSGAFG00000016780pdcd4b8868.499Gambusia_affinis
ENSG00000150593PDCD49360.185ENSGACG00000017601pdcd4a9160.185Gasterosteus_aculeatus
ENSG00000150593PDCD49967.249ENSGACG00000018691pdcd4b9866.953Gasterosteus_aculeatus
ENSG00000150593PDCD410087.420ENSGAGG00000011123PDCD410087.420Gopherus_agassizii
ENSG00000150593PDCD410099.360ENSGGOG00000025550PDCD410099.360Gorilla_gorilla
ENSG00000150593PDCD49360.789ENSHBUG00000010532pdcd4a9360.789Haplochromis_burtoni
ENSG00000150593PDCD49969.869ENSHBUG00000016801pdcd4b10068.632Haplochromis_burtoni
ENSG00000150593PDCD410088.980ENSHGLG00000010690-10087.633Heterocephalus_glaber_female
ENSG00000150593PDCD48788.557ENSHGLG00000001144-9979.765Heterocephalus_glaber_female
ENSG00000150593PDCD410095.736ENSHGLG00100016731PDCD410095.736Heterocephalus_glaber_male
ENSG00000150593PDCD49359.629ENSHCOG00000020305pdcd4a9159.629Hippocampus_comes
ENSG00000150593PDCD49970.524ENSHCOG00000001710pdcd4b10069.409Hippocampus_comes
ENSG00000150593PDCD49457.534ENSIPUG00000002299pdcd4a9358.087Ictalurus_punctatus
ENSG00000150593PDCD410067.797ENSIPUG00000010696pdcd4b10067.797Ictalurus_punctatus
ENSG00000150593PDCD410097.655ENSSTOG00000015625PDCD410097.655Ictidomys_tridecemlineatus
ENSG00000150593PDCD410096.588ENSJJAG00000022140Pdcd410096.588Jaculus_jaculus
ENSG00000150593PDCD49760.314ENSKMAG00000001092pdcd4a9360.538Kryptolebias_marmoratus
ENSG00000150593PDCD49969.214ENSKMAG00000020343pdcd4b9768.455Kryptolebias_marmoratus
ENSG00000150593PDCD49958.261ENSLBEG00000020785pdcd4a9858.261Labrus_bergylta
ENSG00000150593PDCD49866.740ENSLBEG00000025123pdcd4b9965.612Labrus_bergylta
ENSG00000150593PDCD48958.654ENSLACG00000001378pdcd4a8857.014Latimeria_chalumnae
ENSG00000150593PDCD49976.159ENSLACG00000013271PDCD410075.053Latimeria_chalumnae
ENSG00000150593PDCD47356.268ENSLOCG00000002395pdcd4a9656.232Lepisosteus_oculatus
ENSG00000150593PDCD49973.789ENSLOCG00000012312pdcd4b9972.553Lepisosteus_oculatus
ENSG00000150593PDCD410090.021ENSLAFG00000014885PDCD410090.021Loxodonta_africana
ENSG00000150593PDCD410098.472ENSMFAG00000001786PDCD410098.472Macaca_fascicularis
ENSG00000150593PDCD410098.472ENSMMUG00000017204PDCD410098.940Macaca_mulatta
ENSG00000150593PDCD410098.472ENSMNEG00000043104PDCD410098.472Macaca_nemestrina
ENSG00000150593PDCD410098.472ENSMLEG00000035966PDCD410098.472Mandrillus_leucophaeus
ENSG00000150593PDCD49968.928ENSMAMG00000014502pdcd4b9970.439Mastacembelus_armatus
ENSG00000150593PDCD49360.599ENSMAMG00000016154pdcd4a9161.485Mastacembelus_armatus
ENSG00000150593PDCD49969.869ENSMZEG00005003005pdcd4b10068.632Maylandia_zebra
ENSG00000150593PDCD49360.789ENSMZEG00005019782pdcd4a9260.789Maylandia_zebra
ENSG00000150593PDCD49986.755ENSMGAG00000010847PDCD410084.648Meleagris_gallopavo
ENSG00000150593PDCD410097.655ENSMAUG00000011866Pdcd410097.655Mesocricetus_auratus
ENSG00000150593PDCD410098.081ENSMICG00000008747PDCD410098.081Microcebus_murinus
ENSG00000150593PDCD410096.802ENSMOCG00000022153Pdcd410096.802Microtus_ochrogaster
ENSG00000150593PDCD48263.660ENSMMOG00000006425pdcd4a9958.036Mola_mola
ENSG00000150593PDCD49470.507ENSMMOG00000021600pdcd4b9970.507Mola_mola
ENSG00000150593PDCD49996.468ENSMODG00000010390PDCD410095.309Monodelphis_domestica
ENSG00000150593PDCD49768.233ENSMALG00000001132pdcd4b10067.171Monopterus_albus
ENSG00000150593PDCD49858.057ENSMALG00000001597pdcd4a9658.057Monopterus_albus
ENSG00000150593PDCD410096.375MGP_CAROLIEiJ_G0023076Pdcd410096.375Mus_caroli
ENSG00000150593PDCD410096.802ENSMUSG00000024975Pdcd410096.802Mus_musculus
ENSG00000150593PDCD410097.228MGP_PahariEiJ_G0014564Pdcd410097.228Mus_pahari
ENSG00000150593PDCD410096.802MGP_SPRETEiJ_G0023997Pdcd410096.802Mus_spretus
ENSG00000150593PDCD410098.294ENSMPUG00000002065PDCD410098.294Mustela_putorius_furo
ENSG00000150593PDCD410096.375ENSMLUG00000013798PDCD410096.375Myotis_lucifugus
ENSG00000150593PDCD410096.802ENSNGAG00000022282Pdcd410096.802Nannospalax_galili
ENSG00000150593PDCD49969.935ENSNBRG00000003325pdcd4b10068.697Neolamprologus_brichardi
ENSG00000150593PDCD49460.460ENSNBRG00000013163pdcd4a9860.460Neolamprologus_brichardi
ENSG00000150593PDCD410098.721ENSNLEG00000015556PDCD410098.721Nomascus_leucogenys
ENSG00000150593PDCD461100.000ENSMEUG00000001531-79100.000Notamacropus_eugenii
ENSG00000150593PDCD410097.015ENSOPRG00000015442PDCD410097.015Ochotona_princeps
ENSG00000150593PDCD410095.522ENSODEG00000009436PDCD410095.522Octodon_degus
ENSG00000150593PDCD49970.087ENSONIG00000016289pdcd4b10068.697Oreochromis_niloticus
ENSG00000150593PDCD49360.789ENSONIG00000017552pdcd4a9260.557Oreochromis_niloticus
ENSG00000150593PDCD410093.177ENSOANG00000001593PDCD410093.177Ornithorhynchus_anatinus
ENSG00000150593PDCD410098.081ENSOCUG00000016822PDCD410098.081Oryctolagus_cuniculus
ENSG00000150593PDCD49467.824ENSORLG00000015298pdcd4b9867.824Oryzias_latipes
ENSG00000150593PDCD49760.491ENSORLG00000006416pdcd4a9760.087Oryzias_latipes
ENSG00000150593PDCD410065.890ENSORLG00020017175pdcd4b9965.890Oryzias_latipes_hni
ENSG00000150593PDCD49760.268ENSORLG00020021241pdcd4a9759.870Oryzias_latipes_hni
ENSG00000150593PDCD410065.890ENSORLG00015017839pdcd4b9965.890Oryzias_latipes_hsok
ENSG00000150593PDCD49760.491ENSORLG00015021438pdcd4a9760.087Oryzias_latipes_hsok
ENSG00000150593PDCD49967.249ENSOMEG00000006923pdcd4b10066.245Oryzias_melastigma
ENSG00000150593PDCD49759.821ENSOMEG00000006883pdcd4a9658.913Oryzias_melastigma
ENSG00000150593PDCD410097.655ENSOGAG00000012583PDCD410097.655Otolemur_garnettii
ENSG00000150593PDCD410097.015ENSOARG00000010432PDCD410097.015Ovis_aries
ENSG00000150593PDCD410099.574ENSPPAG00000041002PDCD410099.574Pan_paniscus
ENSG00000150593PDCD410097.868ENSPPRG00000009147PDCD410097.868Panthera_pardus
ENSG00000150593PDCD410097.868ENSPTIG00000010679PDCD410097.868Panthera_tigris_altaica
ENSG00000150593PDCD410099.574ENSPTRG00000002940PDCD410099.574Pan_troglodytes
ENSG00000150593PDCD410098.472ENSPANG00000020809PDCD410098.472Papio_anubis
ENSG00000150593PDCD49973.289ENSPKIG00000017462pdcd4b10072.281Paramormyrops_kingsleyae
ENSG00000150593PDCD49859.560ENSPKIG00000011507pdcd4a9960.586Paramormyrops_kingsleyae
ENSG00000150593PDCD49362.413ENSPKIG00000017390pdcd4a9562.413Paramormyrops_kingsleyae
ENSG00000150593PDCD410086.354ENSPSIG00000010097PDCD410086.354Pelodiscus_sinensis
ENSG00000150593PDCD49073.206ENSPMGG00000002938pdcd4b9761.996Periophthalmus_magnuspinnatus
ENSG00000150593PDCD49955.652ENSPMGG00000009956pdcd4a9755.870Periophthalmus_magnuspinnatus
ENSG00000150593PDCD410096.588ENSPEMG00000002505Pdcd410096.588Peromyscus_maniculatus_bairdii
ENSG00000150593PDCD49996.468ENSPCIG00000000171PDCD410095.309Phascolarctos_cinereus
ENSG00000150593PDCD49358.933ENSPFOG00000011856pdcd4a9158.933Poecilia_formosa
ENSG00000150593PDCD49968.547ENSPFOG00000005006pdcd4b10067.364Poecilia_formosa
ENSG00000150593PDCD49968.996ENSPLAG00000010423pdcd4b10067.789Poecilia_latipinna
ENSG00000150593PDCD49359.165ENSPLAG00000015991pdcd4a9159.165Poecilia_latipinna
ENSG00000150593PDCD49470.968ENSPMEG00000006444pdcd4b9870.968Poecilia_mexicana
ENSG00000150593PDCD49658.145ENSPMEG00000018352pdcd4a9358.145Poecilia_mexicana
ENSG00000150593PDCD49968.996ENSPREG00000000296pdcd4b10067.789Poecilia_reticulata
ENSG00000150593PDCD49359.165ENSPREG00000005622pdcd4a9859.165Poecilia_reticulata
ENSG00000150593PDCD410098.294ENSPPYG00000002649PDCD410098.294Pongo_abelii
ENSG00000150593PDCD410089.388ENSPCAG00000014164PDCD410084.009Procavia_capensis
ENSG00000150593PDCD49497.696ENSPCOG00000021133PDCD410091.850Propithecus_coquereli
ENSG00000150593PDCD410096.588ENSPVAG00000016247PDCD410096.588Pteropus_vampyrus
ENSG00000150593PDCD49969.869ENSPNYG00000002060pdcd4b10068.632Pundamilia_nyererei
ENSG00000150593PDCD49360.789ENSPNYG00000009383pdcd4a9260.789Pundamilia_nyererei
ENSG00000150593PDCD49759.121ENSPNAG00000011656pdcd4a9658.280Pygocentrus_nattereri
ENSG00000150593PDCD49971.429ENSPNAG00000018427pdcd4b10070.127Pygocentrus_nattereri
ENSG00000150593PDCD410096.802ENSRNOG00000014779Pdcd410096.802Rattus_norvegicus
ENSG00000150593PDCD49996.352ENSRBIG00000036033PDCD410096.352Rhinopithecus_bieti
ENSG00000150593PDCD410098.908ENSRROG00000042371PDCD410098.908Rhinopithecus_roxellana
ENSG00000150593PDCD410098.507ENSSBOG00000026392PDCD410098.507Saimiri_boliviensis_boliviensis
ENSG00000150593PDCD49996.468ENSSHAG00000012060PDCD410095.309Sarcophilus_harrisii
ENSG00000150593PDCD49871.269ENSSFOG00015008116pdcd49970.108Scleropages_formosus
ENSG00000150593PDCD49958.422ENSSFOG00015017220pdcd4a9958.422Scleropages_formosus
ENSG00000150593PDCD49659.910ENSSFOG00015018958pdcd4a9360.000Scleropages_formosus
ENSG00000150593PDCD49967.756ENSSMAG00000001335pdcd4b10066.737Scophthalmus_maximus
ENSG00000150593PDCD49756.494ENSSMAG00000007600pdcd4a9159.397Scophthalmus_maximus
ENSG00000150593PDCD49968.627ENSSDUG00000010112pdcd4b10067.579Seriola_dumerili
ENSG00000150593PDCD49759.041ENSSDUG00000002569pdcd4a9759.041Seriola_dumerili
ENSG00000150593PDCD49968.627ENSSLDG00000012296pdcd4b10067.579Seriola_lalandi_dorsalis
ENSG00000150593PDCD49759.477ENSSLDG00000016547pdcd4a9759.477Seriola_lalandi_dorsalis
ENSG00000150593PDCD410091.020ENSSARG00000008245PDCD410088.486Sorex_araneus
ENSG00000150593PDCD49985.872ENSSPUG00000004443PDCD410084.435Sphenodon_punctatus
ENSG00000150593PDCD49969.651ENSSPAG00000005146pdcd4b10068.421Stegastes_partitus
ENSG00000150593PDCD49360.093ENSSPAG00000000564pdcd4a9460.325Stegastes_partitus
ENSG00000150593PDCD410097.441ENSSSCG00000010627PDCD410097.441Sus_scrofa
ENSG00000150593PDCD49486.636ENSTGUG00000015607-9984.836Taeniopygia_guttata
ENSG00000150593PDCD49987.638ENSTGUG00000010667-10085.714Taeniopygia_guttata
ENSG00000150593PDCD49759.417ENSTRUG00000002085pdcd4a9858.297Takifugu_rubripes
ENSG00000150593PDCD49866.886ENSTRUG00000007652pdcd4b9965.539Takifugu_rubripes
ENSG00000150593PDCD49965.116ENSTNIG00000010581pdcd4b9965.116Tetraodon_nigroviridis
ENSG00000150593PDCD49757.987ENSTNIG00000018044pdcd4a9857.987Tetraodon_nigroviridis
ENSG00000150593PDCD410090.612ENSTBEG00000000362PDCD410090.192Tupaia_belangeri
ENSG00000150593PDCD410091.045ENSTTRG00000006972PDCD410091.045Tursiops_truncatus
ENSG00000150593PDCD49998.242ENSUAMG00000024332PDCD410097.783Ursus_americanus
ENSG00000150593PDCD410098.081ENSUMAG00000023745PDCD410098.081Ursus_maritimus
ENSG00000150593PDCD410096.802ENSVPAG00000001758PDCD410096.802Vicugna_pacos
ENSG00000150593PDCD410098.507ENSVVUG00000007900PDCD410098.507Vulpes_vulpes
ENSG00000150593PDCD45358.678ENSXETG00000002778-9658.678Xenopus_tropicalis
ENSG00000150593PDCD49776.126ENSXETG00000025248pdcd410072.766Xenopus_tropicalis
ENSG00000150593PDCD49570.872ENSXCOG00000014651pdcd4b9970.872Xiphophorus_couchianus
ENSG00000150593PDCD49359.070ENSXCOG00000011222pdcd4a9959.070Xiphophorus_couchianus
ENSG00000150593PDCD49358.933ENSXMAG00000005480pdcd4a9158.933Xiphophorus_maculatus
ENSG00000150593PDCD49969.214ENSXMAG00000006928pdcd4b10068.000Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding-IEAFunction
GO:0005515protein binding12054647.16357133.18296639.19204291.21163940.24413684.25416956.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus16357133.IMPComponent
GO:0005634nucleus-ISSComponent
GO:0005737cytoplasm16357133.IMPComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol12054647.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006915apoptotic process12054647.NASProcess
GO:0007569cell aging12054647.IDAProcess
GO:0030509BMP signaling pathway18548003.IDAProcess
GO:0035722interleukin-12-mediated signaling pathway-TASProcess
GO:0043066negative regulation of apoptotic process-IEAProcess
GO:0043508negative regulation of JUN kinase activity-ISSProcess
GO:0045786negative regulation of cell cycle12054647.NASProcess
GO:0045892negative regulation of transcription, DNA-templated16357133.IDAProcess
GO:0045892negative regulation of transcription, DNA-templated-ISSProcess
GO:0050729positive regulation of inflammatory response-ISSProcess
GO:0060940epithelial to mesenchymal transition involved in cardiac fibroblast development-ISSProcess
GO:0071222cellular response to lipopolysaccharide-ISSProcess
GO:1900016negative regulation of cytokine production involved in inflammatory response-ISSProcess
GO:1901224positive regulation of NIK/NF-kappaB signaling19946272.IMPProcess
GO:1904706negative regulation of vascular smooth muscle cell proliferation28522568.IMPProcess
GO:1904761negative regulation of myofibroblast differentiation20533548.IMPProcess
GO:1905064negative regulation of vascular smooth muscle cell differentiation18548003.IDAProcess
GO:1905461positive regulation of vascular associated smooth muscle cell apoptotic process28522568.IMPProcess
GO:2000353positive regulation of endothelial cell apoptotic process24732886.IMPProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us