EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	10258475	Silent	novel	V271V	0.16
BLCA	chr5	10256072	Missense_Mutation	novel	K150R	0.35
BLCA	chr5	10256122	Missense_Mutation	rs199552031	Q167E	0.63
BLCA	chr5	10254680	Missense_Mutation	NA	D58V	0.23
BLCA	chr5	10254830	Missense_Mutation	NA	G108E	0.52
BLCA	chr5	10254189	Silent	NA	T50T	0.39
BLCA	chr5	10258395	Missense_Mutation	NA	D245N	0.12
BLCA	chr5	10261729	Missense_Mutation	novel	R388T	0.28
BRCA	chr5	10261597	Missense_Mutation	NA	R344M	0.42
BRCA	chr5	10250557	Intron	novel		0.2
BRCA	chr5	10261612	Missense_Mutation	rs762786367	T349I	0.13
CESC	chr5	10261721	Silent	novel	I385I	0.25
CESC	chr5	10260881	Silent	rs768453858	A321A	0.07
CESC	chr5	10261584	Missense_Mutation	NA	R340W	0.39
CESC	chr5	10250633	Intron	novel		0.11
CESC	chr5	10261584	Missense_Mutation	NA	R340W	0.4
CESC	chr5	10264849	3'UTR	novel		0.32
COAD	chr5	10255961	Missense_Mutation	NA	A113D	0.29
COAD	chr5	10250184	5'UTR	novel		0.2
COAD	chr5	10261572	Missense_Mutation	rs768768696	A336T	0.24
COAD	chr5	10261870	Intron	novel		0.36
COAD	chr5	10255982	Missense_Mutation	novel	A120V	0.07
COAD	chr5	10261572	Missense_Mutation	rs768768696	A336T	0.26
COAD	chr5	10250279	5'UTR	rs745378487		0.42
COAD	chr5	10258228	Silent	rs754143874	G216G	0.33
COAD	chr5	10258481	Missense_Mutation	novel	D273E	0.12
COAD	chr5	10265029	3'UTR	novel		0.36
COAD	chr5	10262510	Silent	rs771307325	H403H	0.35
COAD	chr5	10263216	Missense_Mutation	NA	G467D	0.15
COAD	chr5	10264931	3'UTR	novel		0.15
COAD	chr5	10263176	Missense_Mutation	NA	A454T	0.17
COAD	chr5	10264950	3'UTR	novel		0.37
DLBC	chr5	10262588	Silent	novel	C429C	0.08
ESCA	chr5	10256085	Silent	novel	S154S	0.12
ESCA	chr5	10250327	5'UTR	novel		0.11
ESCA	chr5	10250340	5'UTR	novel		0.64
ESCA	chr5	10260852	Missense_Mutation	novel	H312N	0.15
ESCA	chr5	10254745	Missense_Mutation	rs779876496	M80V	0.36
GBM	chr5	10264714	Silent	novel	L519L	0.25
GBM	chr5	10262541	Missense_Mutation	NA	R414S	0.36
GBM	chr5	10261608	Missense_Mutation	novel	L348F	0.2
GBM	chr5	10264710	Missense_Mutation	novel	S518Y	0.46
HNSC	chr5	10258409	Silent	novel	A249A	0.3
HNSC	chr5	10250371	Missense_Mutation	novel	E11K	0.14
HNSC	chr5	10262544	Missense_Mutation	rs11557654	D415N	0.18
HNSC	chr5	10256133	Nonsense_Mutation	novel	*K170_T171insLHFY**	0.23
HNSC	chr5	10263255	Missense_Mutation	novel	R480K	0.35
HNSC	chr5	10256124	Silent	novel	Q167Q	0.47
KIRC	chr5	10264858	3'UTR	novel		0.15
KIRP	chr5	10261639	Missense_Mutation	NA	L358R	0.1
KIRP	chr5	10263307	Silent	rs771882069	G497G	0.46
LGG	chr5	10264810	3'UTR	rs776573338		0.17
LGG	chr5	10265057	3'UTR	novel		0.33
LGG	chr5	10254774	Silent	novel	K89K	0.4
LGG	chr5	10262542	Missense_Mutation	novel	R414H	0.36
LIHC	chr5	10258175	Missense_Mutation	novel	M199V	0.15
LIHC	chr5	10258303	Missense_Mutation	NA	K241N	0.17
LIHC	chr5	10250354	Missense_Mutation	novel	G5V	0.34
LIHC	chr5	10250192	5'UTR	novel		0.23
LUAD	chr5	10258461	Missense_Mutation	NA	D267Y	0.08
LUAD	chr5	10254711	Silent	novel	V68V	0.34
LUAD	chr5	10256073	Missense_Mutation	NA	K150N	0.15
LUAD	chr5	10256074	Missense_Mutation	novel	I151F	0.16
LUAD	chr5	10258509	Nonsense_Mutation	NA	E283*	0.2
LUAD	chr5	10263176	Missense_Mutation	novel	A454P	0.07
LUAD	chr5	10250330	5'UTR	novel		0.34
LUAD	chr5	10261636	Missense_Mutation	NA	G357V	0.08
LUSC	chr5	10254802	Missense_Mutation	NA	D99Y	0.24
LUSC	chr5	10258406	Silent	novel	I248I	0.07
LUSC	chr5	10264788	3'UTR	novel		0.46
LUSC	chr5	10250355	Silent	rs754687206	G5G	0.47
LUSC	chr5	10250250	5'UTR	novel		0.24
LUSC	chr5	10258239	Missense_Mutation	novel	E220G	0.17
LUSC	chr5	10254204	Splice_Region	rs775126012	N55N	0.2
LUSC	chr5	10261708	Missense_Mutation	novel	R381T	0.13
MESO	chr5	10258256	Frame_Shift_Del	novel	*K226Rfs3**	0.39
OV	chr5	10263223	Missense_Mutation	NA	N469K	0.32
OV	chr5	10258226	Missense_Mutation	NA	G216S	0.4
PAAD	chr5	10250376	Silent	rs111848991	Y12Y	0.15
PAAD	chr5	10256079	Silent	NA	S152S	0.11
PAAD	chr5	10258502	Silent	NA	Y280Y	0.15
PAAD	chr5	10261688	Silent	rs773531721	I374I	0.17
READ	chr5	10262540	Silent	novel	I413I	0.37
READ	chr5	10264911	3'UTR	novel		0.39
SARC	chr5	10262554	Frame_Shift_Del	novel	*V418Gfs26**	0.36
SARC	chr5	10258157	Missense_Mutation	novel	V193I	0.37
SARC	chr5	10258262	Missense_Mutation	rs368338119	V228M	0.38
SARC	chr5	10261617	Missense_Mutation	rs140095139	E351K	0.19
SKCM	chr5	10250353	Missense_Mutation	novel	G5R	0.76
SKCM	chr5	10250299	5'UTR	rs753635806		0.37
SKCM	chr5	10261589	Silent	NA	I341I	0.23
SKCM	chr5	10263191	Missense_Mutation	NA	P459S	0.14
SKCM	chr5	10256024	Missense_Mutation	NA	A134V	0.38
SKCM	chr5	10258265	Missense_Mutation	novel	I229V	0.12
SKCM	chr5	10263225	Missense_Mutation	NA	P470L	0.25
STAD	chr5	10254795	Missense_Mutation	rs772697210	K96N	0.07
STAD	chr5	10260853	Missense_Mutation	NA	H312R	0.04
STAD	chr5	10264703	Nonsense_Mutation	NA	Q516*	0.19
STAD	chr5	10262494	Missense_Mutation	rs201810364	A398V	0.33
STAD	chr5	10250367	Silent	rs377019090	F9F	0.35
STAD	chr5	10264790	3'UTR	novel		0.23
STAD	chr5	10261649	Silent	novel	E361E	0.07
STAD	chr5	10258502	Silent	NA	Y280Y	0.08
STAD	chr5	10261584	Missense_Mutation	NA	R340W	0.24
THCA	chr5	10256134	Frame_Shift_Ins	novel	*T171Sfs17**	0.09
THCA	chr5	10264931	3'UTR	novel		0.14
THYM	chr5	10260880	Missense_Mutation	novel	A321V	0.24
UCEC	chr5	10250362	Missense_Mutation	NA	A8T	0.5
UCEC	chr5	10256110	Missense_Mutation	rs552008894	E163K	0.33
UCEC	chr5	10261723	Missense_Mutation	NA	F386C	0.41
UCEC	chr5	10254181	Missense_Mutation	novel	M48L	0.36
UCEC	chr5	10255960	Missense_Mutation	novel	A113T	0.29
UCEC	chr5	10264757	Missense_Mutation	rs375499316	R534C	0.47
UCEC	chr5	10262526	Missense_Mutation	novel	I409V	0.13
UCEC	chr5	10261680	Silent	NA	L372L	0.36
UCEC	chr5	10258261	Silent	rs535459086	G227G	0.46
UCEC	chr5	10264757	Missense_Mutation	rs375499316	R534C	0.1
UCEC	chr5	10250375	Missense_Mutation	novel	Y12C	0.14
UCEC	chr5	10262611	Missense_Mutation	rs149067488	A437V	0.27
UCEC	chr5	10254152	Missense_Mutation	NA	I38T	0.45
UCEC	chr5	10262590	Missense_Mutation	NA	A430V	0.52
UCEC	chr5	10255999	Nonsense_Mutation	novel	R126*	0.31
UCEC	chr5	10258189	Silent	novel	D203D	0.34
UCEC	chr5	10256079	Silent	NA	S152S	0.44
UCEC	chr5	10258228	Silent	rs754143874	G216G	0.27
UCEC	chr5	10261755	Intron	novel		0.16
UCEC	chr5	10258515	In_Frame_Ins	novel	F285delinsSNDV	0.04
UCEC	chr5	10260800	Missense_Mutation	novel	E294D	0.38
UCEC	chr5	10262494	Missense_Mutation	rs201810364	A398V	0.5
UCEC	chr5	10263289	Silent	novel	I491I	0.08
UCEC	chr5	10262590	Missense_Mutation	NA	A430V	0.26
UCEC	chr5	10261584	Missense_Mutation	NA	R340W	0.22
UCEC	chr5	10262511	Missense_Mutation	rs774663416	D404N	0.04
UCEC	chr5	10256109	Silent	rs376585317	T162T	0.2
UCEC	chr5	10258261	Silent	rs535459086	G227G	0.21
UCEC	chr5	10261627	Missense_Mutation	NA	G354D	0.33
UCEC	chr5	10258425	Missense_Mutation	novel	F255I	0.32
UCEC	chr5	10256016	Silent	NA	I131I	0.13
UCEC	chr5	10258502	Silent	NA	Y280Y	0.07
UCEC	chr5	10265084	3'UTR	novel		0.33
UCEC	chr5	10256079	Silent	NA	S152S	0.55
UCS	chr5	10264884	3'UTR	novel		0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.09673
SKCM	DEL	0.1608	0.011094
TGCT	DEL	0.5733	0.098913
THCA	DEL	0.004	0.23456

Survival Analysis

Cancer	P-value	Q-value
THYM	0.024	Kaplan-Meier Survival Analysis
SARC	0.00013	Kaplan-Meier Survival Analysis
MESO	0.00019	Kaplan-Meier Survival Analysis
ACC	0.0074	Kaplan-Meier Survival Analysis
HNSC	0.024	Kaplan-Meier Survival Analysis
BRCA	0.011	Kaplan-Meier Survival Analysis
KIRP	0.0027	Kaplan-Meier Survival Analysis
PAAD	0.01	Kaplan-Meier Survival Analysis
LAML	0.024	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
UCEC	0.023	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LUAD	0.00034	Kaplan-Meier Survival Analysis
UVM	0.00042	Kaplan-Meier Survival Analysis
OV	0.001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000150753 (Gene tree)
Gene ID: 22948
Gene Symbol: CCT5
Alias: KIAA0098
Full Name: chaperonin containing TCP1 subunit 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 16,492 bases
Position: chr5:10,249,921-10,266,412
Accession: 1618
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512975	CCT5-211	578	-	ENSP00000425751	44 (aa)	-	D6RIZ7
ENST00000503454	CCT5-204	762	-	ENSP00000422744	62 (aa)	-	H0Y914
ENST00000510326	CCT5-208	567	-	-	- (aa)	-	-
ENST00000515676	CCT5-214	1997	-	ENSP00000427297	503 (aa)	-	B7ZAR1
ENST00000423695	CCT5-202	1232	-	-	- (aa)	-	-
ENST00000509846	CCT5-207	546	-	-	- (aa)	-	-
ENST00000508451	CCT5-206	555	-	-	- (aa)	-	-
ENST00000511995	CCT5-210	1091	-	-	- (aa)	-	-
ENST00000503026	CCT5-203	1933	-	ENSP00000423318	520 (aa)	-	E9PCA1
ENST00000280326	CCT5-201	3675	-	ENSP00000280326	541 (aa)	-	P48643
ENST00000514674	CCT5-212	568	-	-	- (aa)	-	-
ENST00000515390	CCT5-213	1728	-	ENSP00000426923	486 (aa)	-	E7ENZ3
ENST00000506600	CCT5-205	1939	-	ENSP00000423052	448 (aa)	-	P48643
ENST00000511700	CCT5-209	582	-	ENSP00000423087	88 (aa)	-	H0Y958
ENST00000625723	CCT5-215	135	-	ENSP00000487128	44 (aa)	-	D6RIZ7

Gene Model

Click here to download ENSG00000150753's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000150753's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000150753	CCT5	99	70.482	WBGene00000380	cct-5	98	70.821	Caenorhabditis_elegans
ENSG00000150753	CCT5	99	71.800	FBgn0010621	CCT5	99	71.344	Drosophila_melanogaster
ENSG00000150753	CCT5	100	96.303	ENSMUSG00000022234	Cct5	100	96.303	Mus_musculus
ENSG00000150753	CCT5	99	59.707	YJR064W	CCT5	97	59.707	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003730	mRNA 3'-UTR binding	16213212.	IDA	Function
GO:0005515	protein binding	14532270.16189514.24375412.25467444.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005813	centrosome	20080638.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005832	chaperonin-containing T-complex	21873635.	IBA	Component
GO:0005832	chaperonin-containing T-complex	23011926.	IDA	Component
GO:0005832	chaperonin-containing T-complex	25467444.	TAS	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006457	protein folding	-	TAS	Process
GO:0007339	binding of sperm to zona pellucida	-	IEA	Process
GO:0009615	response to virus	16548883.	IEP	Process
GO:0031681	G-protein beta-subunit binding	19376773.	IPI	Function
GO:0032212	positive regulation of telomere maintenance via telomerase	25467444.	IMP	Process
GO:0044297	cell body	-	IEA	Component
GO:0048027	mRNA 5'-UTR binding	16213212.	IDA	Function
GO:0048487	beta-tubulin binding	24375412.	IPI	Function
GO:0050821	protein stabilization	25467444.	IMP	Process
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component
GO:1901998	toxin transport	-	IEA	Process
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.