EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23224145	MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion.	Breast Cancer Res Treat	2013 Jan	Bockhorn J	doi: 10.1007/s10549-012-2346-4

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	43796991	Missense_Mutation	novel	M289I	0.7
BLCA	chr12	43802340	Silent	novel	Q76Q	0.16
BLCA	chr12	43800521	Missense_Mutation	novel	K98E	0.11
BLCA	chr12	43802366	Missense_Mutation	novel	Y68H	0.13
BLCA	chr12	43796980	Missense_Mutation	novel	R293I	0.48
BLCA	chr12	43795511	3'UTR	novel		0.36
BRCA	chr12	43802438	Missense_Mutation	novel	Q44E	0.26
BRCA	chr12	43797784	Missense_Mutation	NA	V178A	0.21
BRCA	chr12	43795525	3'UTR	novel		0.14
BRCA	chr12	43797800	Missense_Mutation	NA	Q173E	0.23
CESC	chr12	43805996	Intron	novel		0.36
CESC	chr12	43793885	3'UTR	novel		0.21
CESC	chr12	43804506	Missense_Mutation	novel	S31C	0.16
CESC	chr12	43793872	3'UTR	novel		0.22
COAD	chr12	43797381	Missense_Mutation	NA	K227N	0.26
COAD	chr12	43800513	Silent	NA	L100L	0.26
COAD	chr12	43797436	Frame_Shift_Del	NA	*N209Mfs4**	0.19
COAD	chr12	43797013	Missense_Mutation	NA	I282S	0.28
COAD	chr12	43799450	Missense_Mutation	novel	P144H	0.14
COAD	chr12	43800512	Missense_Mutation	NA	Y101H	0.31
ESCA	chr12	43794306	3'UTR	novel		0.14
HNSC	chr12	43797348	Silent	novel	F238F	0.3
KIRP	chr12	43804524	Missense_Mutation	rs753601193	Y25C	0.23
LIHC	chr12	43806209	Intron	novel		0.5
LUAD	chr12	43804564	Missense_Mutation	novel	D12N	0.11
LUAD	chr12	43802307	Silent	novel	A87A	0.66
LUAD	chr12	43802420	Missense_Mutation	NA	D50Y	0.42
LUAD	chr12	43799395	Splice_Region	novel		0.24
LUSC	chr12	43795720	Silent	novel	D306D	0.06
LUSC	chr12	43805892	Intron	novel		0.1
LUSC	chr12	43802311	Missense_Mutation	NA	I86T	0.26
MESO	chr12	43805909	Intron	novel		0.37
OV	chr12	43795578	3'UTR	novel		0.47
PAAD	chr12	43797453	Splice_Site	novel	X204_splice	0.13
PRAD	chr12	43795729	Missense_Mutation	NA	L303F	0.41
PRAD	chr12	43797000	Missense_Mutation	novel	Q286H	0.46
READ	chr12	43800435	Splice_Region	NA	K126K	0.24
READ	chr12	43795654	Silent	rs755933337	G328G	0.37
READ	chr12	43796991	Missense_Mutation	novel	M289I	0.4
READ	chr12	43799476	Missense_Mutation	NA	K135N	0.4
READ	chr12	43802323	Missense_Mutation	NA	E82A	0.19
SKCM	chr12	43795576	3'UTR	rs768039861		0.41
SKCM	chr12	43795493	3'UTR	novel		0.13
SKCM	chr12	43797329	Missense_Mutation	novel	H245Y	0.09
SKCM	chr12	43805924	Intron	novel		0.1
SKCM	chr12	43799424	Missense_Mutation	NA	E153K	0.25
SKCM	chr12	43805907	Intron	novel		0.24
STAD	chr12	43797740	Missense_Mutation	NA	L193M	0.27
STAD	chr12	43797711	Silent	NA	Q202Q	0.09
STAD	chr12	43799473	Frame_Shift_Del	novel	*K136Nfs12**	0.38
THCA	chr12	43797412	In_Frame_Ins	novel	T217delinsRADTP	0.06
UCEC	chr12	43799499	Missense_Mutation	NA	D128Y	0.3
UCEC	chr12	43805941	Intron	novel		0.26
UCEC	chr12	43795359	3'UTR	novel		0.12
UCEC	chr12	43797048	Missense_Mutation	rs756874040	M270I	0.17
UCEC	chr12	43793971	3'UTR	novel		0.33
UCEC	chr12	43794055	3'UTR	novel		0.49
UCEC	chr12	43796976	Missense_Mutation	novel	K294N	0.39
UCEC	chr12	43804499	Missense_Mutation	novel	E33D	0.33
UCEC	chr12	43797067	Missense_Mutation	novel	C264F	0.43
UCEC	chr12	43795549	3'UTR	novel		0.37
UCEC	chr12	43802344	Missense_Mutation	novel	S75Y	0.28
UCEC	chr12	43797343	Missense_Mutation	NA	L240P	0.43
UCEC	chr12	43797381	Missense_Mutation	NA	K227N	0.25
UCEC	chr12	43799417	Missense_Mutation	rs370535868	R155Q	0.13
UCEC	chr12	43800483	Missense_Mutation	NA	K110N	0.26
UCEC	chr12	43802284	Splice_Site	NA	X94_splice	0.2
UCEC	chr12	43797323	Nonsense_Mutation	novel	G247*	0.17
UCEC	chr12	43802323	Missense_Mutation	novel	E82V	0.21
UCEC	chr12	43794788	3'UTR	novel		0.22
UCEC	chr12	43799421	Missense_Mutation	NA	L154V	0.29
UCEC	chr12	43793810	3'UTR	novel		0.42
UCEC	chr12	43794340	3'UTR	novel		0.2
UCEC	chr12	43795312	3'UTR	novel		0.35
UCEC	chr12	43797740	Frame_Shift_Ins	novel	*L193Ifs3**	0.2
UCEC	chr12	43797401	Missense_Mutation	novel	E221K	0.27
UCEC	chr12	43797436	Frame_Shift_Del	NA	*N209Mfs4**	0.32
UCEC	chr12	43797358	Missense_Mutation	rs201989375	R235H	0.37
UCEC	chr12	43795743	Missense_Mutation	novel	N299D	0.38
UCEC	chr12	43804553	Missense_Mutation	novel	E15D	0.42
UCEC	chr12	43793738	3'UTR	novel		0.53
UCEC	chr12	43794538	3'UTR	novel		0.36
UCEC	chr12	43797047	Missense_Mutation	NA	L271M	0.31
UCEC	chr12	43797358	Missense_Mutation	rs201989375	R235H	0.28
UCEC	chr12	43793728	3'UTR	novel		0.35
UCEC	chr12	43795525	3'UTR	novel		0.45
UCEC	chr12	43795255	3'UTR	novel		0.4
UCEC	chr12	43797348	Missense_Mutation	NA	F238L	0.23
UCEC	chr12	43795311	3'UTR	novel		0.46
UCEC	chr12	43795484	3'UTR	novel		0.2
UCEC	chr12	43797446	Missense_Mutation	novel	D206Y	0.33
UCEC	chr12	43802297	Missense_Mutation	rs754175239	D91Y	0.26
UCEC	chr12	43794518	3'UTR	novel		0.3
UCEC	chr12	43793737	3'UTR	novel		0.1
UCEC	chr12	43795525	3'UTR	novel		0.12
UCEC	chr12	43805860	Intron	novel		0.18
UCEC	chr12	43793804	3'UTR	novel		0.36
UCEC	chr12	43794401	3'UTR	novel		0.26
UCEC	chr12	43794401	3'UTR	novel		0.36
UCEC	chr12	43797430	Missense_Mutation	NA	I211S	0.37
UCEC	chr12	43797348	Missense_Mutation	NA	F238L	0.28
UCEC	chr12	43799476	Missense_Mutation	NA	K135N	0.33
UCEC	chr12	43797379	Missense_Mutation	novel	R228M	0.19
UCEC	chr12	43793740	3'UTR	novel		0.65
UCEC	chr12	43794099	3'UTR	novel		0.42
UCEC	chr12	43794198	3'UTR	novel		0.42
UCEC	chr12	43797053	Missense_Mutation	rs770428704	R269W	0.16
UCEC	chr12	43795628	Missense_Mutation	rs758446308	R337K	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.1213	4.329e-05
LGG	DEL	0.1053	0.00097114
READ	DEL	0.0909	0.064633
STAD	DEL	0.102	0.22179

Survival Analysis

Cancer	P-value	Q-value
THYM	0.028	Kaplan-Meier Survival Analysis
STAD	0.0027	Kaplan-Meier Survival Analysis
MESO	0.0054	Kaplan-Meier Survival Analysis
LUSC	0.015	Kaplan-Meier Survival Analysis
ESCA	0.0035	Kaplan-Meier Survival Analysis
KIRP	0.0079	Kaplan-Meier Survival Analysis
COAD	0.0081	Kaplan-Meier Survival Analysis
PAAD	0.017	Kaplan-Meier Survival Analysis
PCPG	0.013	Kaplan-Meier Survival Analysis
UCEC	0.0064	Kaplan-Meier Survival Analysis
GBM	0.022	Kaplan-Meier Survival Analysis
LIHC	0.0032	Kaplan-Meier Survival Analysis
LGG	0.00041	Kaplan-Meier Survival Analysis
LUAD	0.0004	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000151239 (Gene tree)
Gene ID: 5756
Gene Symbol: TWF1
Alias: A6|PTK9
Full Name: twinfilin actin binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 12,653 bases
Position: chr12:43,793,723-43,806,375
Accession: 9620
RBP type: non-canonical RBP
Summary: This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000551789	TWF1-210	617	-	-	- (aa)	-	-
ENST00000550371	TWF1-209	612	-	ENSP00000448682	59 (aa)	-	F8VRG3
ENST00000547564	TWF1-205	558	-	-	- (aa)	-	-
ENST00000552521	TWF1-211	3012	-	ENSP00000448750	252 (aa)	-	Q12792
ENST00000546662	TWF1-203	925	-	ENSP00000448221	291 (aa)	-	F8VS81
ENST00000548315	TWF1-207	1170	-	ENSP00000449428	357 (aa)	-	Q12792
ENST00000547459	TWF1-204	3320	-	ENSP00000446665	119 (aa)	-	F8W1D0
ENST00000395510	TWF1-201	3045	-	ENSP00000378886	350 (aa)	-	Q12792
ENST00000548403	TWF1-208	396	-	ENSP00000446696	113 (aa)	-	F8W1Q9
ENST00000547961	TWF1-206	455	-	-	- (aa)	-	-
ENST00000546506	TWF1-202	582	-	ENSP00000448230	15 (aa)	-	F8W645

Gene Model

Click here to download ENSG00000151239's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000151239	Inflammatory Bowel Diseases	6E-6	27569725

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000151239's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000151239	TWF1	99	65.217	ENSG00000247596	TWF2	99	65.217	Homo_sapiens
ENSG00000151239	TWF1	100	95.238	ENSMUSG00000022451	Twf1	100	94.857	Mus_musculus
ENSG00000151239	TWF1	98	67.611	ENSMUSG00000023277	Twf2	99	66.377	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	28493397.	IDA	Function
GO:0003785	actin monomer binding	21873635.	IBA	Function
GO:0003785	actin monomer binding	12807912.18837697.	ISS	Function
GO:0004713	protein tyrosine kinase activity	10406962.	IDA	Function
GO:0005515	protein binding	28493397.	IPI	Function
GO:0005524	ATP binding	10406962.	IDA	Function
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	12807912.	ISS	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005884	actin filament	21873635.	IBA	Component
GO:0005911	cell-cell junction	12807912.	ISS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0010591	regulation of lamellipodium assembly	21873635.	IBA	Process
GO:0010613	positive regulation of cardiac muscle hypertrophy	-	IEA	Process
GO:0010976	positive regulation of neuron projection development	21873635.	IBA	Process
GO:0015629	actin cytoskeleton	-	ISS	Component
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	Process
GO:0030016	myofibril	21873635.	IBA	Component
GO:0030016	myofibril	18837697.	ISS	Component
GO:0030042	actin filament depolymerization	21873635.	IBA	Process
GO:0030175	filopodium	12807912.	ISS	Component
GO:0030837	negative regulation of actin filament polymerization	12807912.	ISS	Process
GO:0032587	ruffle membrane	12807912.	ISS	Component
GO:0042989	sequestering of actin monomers	21873635.	IBA	Process
GO:0042989	sequestering of actin monomers	18837697.	ISS	Process
GO:0043538	regulation of actin phosphorylation	10406962.	IDA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048471	perinuclear region of cytoplasm	12807912.	ISS	Component
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051016	barbed-end actin filament capping	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.