EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20655307Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells.Exp Cell Res2010 Oct 15Pan Hdoi: 10.1016/j.yexcr.2010.07.012
23974830Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment.Breast Cancer Res Treat2013 AugHeikkinen Tdoi: 10.1007/s10549-013-2671-2
17010208Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer.BMC Cancer2006 Sep 30Zhou S-
22397984Translation initiation factor eIF4E is a target for tumor cell radiosensitization.Cancer Res2012 May 1Hayman TJdoi: 10.1158/0008-5472.CAN-12-0329
21941146Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray.J Pediatr Hematol Oncol2011 OctOsborne TSdoi: 10.1097/MPH.0b013e318223d0c1.
25025927The ERK/eIF4F/Bcl-XL pathway mediates SGP-2 induced osteosarcoma cells apoptosis in vitro and in vivo.Cancer Lett2014 Oct 1Zhang Zdoi: 10.1016/j.canlet.2014.06.015
26945967eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation.Cancer Lett2016 May 28Yu Ydoi: 10.1016/j.canlet.2016.02.052
23588929Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth.Oncol Rep2013 JunLiang Sdoi: 10.3892/or.2013.2397
17601486Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.Arch Biochem Biophys2007 Sep 1Peffley DM-
25263391eIF4E-mediated translational control of cancer incidence.Biochim Biophys Acta2015 JulBitterman PBdoi: 10.1016/j.bbagrm.2014.09.007
28350134MicroRNA-455-3p functions as a tumor suppressor by targeting eIF4E in prostate cancer.Oncol Rep2017 AprZhao Ydoi: 10.3892/or.2017.5502
26829052Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.Oncogene2016 Sep 8Musa Jdoi: 10.1038/onc.2015.515
28745319The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer.Oncogene2017 Nov 16D'Abronzo LSdoi: 10.1038/onc.2017.233
27900644Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas.J Neurooncol2017 FebFan Wdoi: 10.1007/s11060-016-2327-2
26944016Antibiotic drug rifabutin is effective against lung cancer cells by targeting the eIF4E-β-catenin axis.Biochem Biophys Res Commun2016 Apr 1Li Jdoi: 10.1016/j.bbrc.2016.02.120
24345331Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α.Biochem Pharmacol2014 May 1Cao Jdoi: 10.1016/j.bcp.2013.12.002
17638893Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.Cancer Res2007 Jul 15Larsson O-
25884680Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer.BMC Cancer2015 Apr 9Matsumoto Mdoi: 10.1186/s12885-015-1202-4.
24491247Overexpression of eukaryotic initiation factor 4E is correlated with increased risk for systemic dissemination in node-positive breast cancer patients.J Am Coll Surg2014 AprYin Xdoi: 10.1016/j.jamcollsurg.2013.12.020
21750861The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model.Int J Oncol2011 NovPons Bdoi: 10.3892/ijo.2011.1118
12186496Expression of eukaryotic translation initiation factors 4E and 2alpha correlates with the progression of thyroid carcinoma.Thyroid2001 DecWang S-
15355912Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway.Clin Cancer Res2004 Sep 1Nathan CO-
26498997Knockdown of eIF4E suppresses cell proliferation, invasion and enhances cisplatin cytotoxicity in human ovarian cancer cells.Int J Oncol2015 DecWan Jdoi: 10.3892/ijo.2015.3201
19020722Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis.Oncol Rep2008 DecNoske A-
24845562The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E.Biochem Biophys Res Commun2014 Jun 27Li Wdoi: 10.1016/j.bbrc.2014.05.011
23883783Resistance to EGFR-TKI can be mediated through multiple signaling pathways converging upon cap-dependent translation in EGFR-wild type NSCLC.J Thorac Oncol2013 SepPatel MRdoi: 10.1097/JTO.0b013e31829ce963.
25342548Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.Mol Cancer2014 Oct 24Pang Wdoi: 10.1186/1476-4598-13-240.
25982998Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy.Tumour Biol2015 AugEnyu Ldoi: 10.1007/s13277-015-3348-8
18719964A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-negative breast cancer.Ann Surg Oncol2008 NovHolm Ndoi: 10.1245/s10434-008-0086-9
26572974The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.Adv Protein Chem Struct Biol2015Karaki Sdoi: 10.1016/bs.apcsb.2015.09.001
11771728Ectopic expression of eIF-4E in human colon cancer cells promotes the stimulation of adhesion molecules by transforming growth factorbeta.Cell Commun Adhes2001Rajagopal S-
24239466Dual inhibition by S6K1 and Elf4E is essential for controlling cellular growth and invasion in bladder cancer.Urol Oncol2014 JanKyou Kwon Jdoi: 10.1016/j.urolonc.2013.08.005
25524901eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.Cancer Res2015 Feb 15Avdulov Sdoi: 10.1158/0008-5472.CAN-14-2571
19367274Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.Br J Cancer2009 May 5Coleman LJdoi: 10.1038/sj.bjc.6605044
19289374Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer.Clin Lung Cancer2009 JanKhoury Tdoi: 10.3816/CLC.2009.n.009.
17245113Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E.Cell Cycle2007 Jan 1Culjkovic B-
19383915eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.Cancer Res2009 May 1Graff JRdoi: 10.1158/0008-5472.CAN-08-3472
25755728Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis.Int J Clin Exp Pathol2015 Jan 1Diab-Assaf M-
21159249[Expression and its clinical significance of eIF4E in non-small cell lung cancer].Zhongguo Fei Ai Za Zhi2010 DecZHANG Bdoi: 10.3779/j.issn.1009-3419.2010.12.10.
22456335MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.Cell Cycle2012 Apr 15Labisso WLdoi: 10.4161/cc.20008
19483468Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues.Cancer Biol Ther2009 AugFan S-
23667251Hypoxia-inducible factor-1α (HIF-1α) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions.J Biol Chem2013 Jun 28Yi Tdoi: 10.1074/jbc.M113.471466
23410891HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer.FEBS Lett2013 Mar 18Wang Sdoi: 10.1016/j.febslet.2013.01.042
14732354TLK1B is elevated with eIF4E overexpression in breast cancer.J Surg Res2004 JanNorton KS-
27840955miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer.Oncol Rep2017 JanWang Ddoi: 10.3892/or.2016.5214
27501049Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI.Lab Invest2016 SepAttar-Schneider Odoi: 10.1038/labinvest.2016.77
27618366Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion.FEBS J2016 NovKwegyir-Afful AKdoi: 10.1111/febs.13895
27527252Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK-eIF4E Axis.Trends Biochem Sci2016 OctBramham CRdoi: 10.1016/j.tibs.2016.07.008
28987382Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5.Toxicol Appl Pharmacol2017 Dec 1Zhang Bdoi: 10.1016/j.taap.2017.10.002
29374693Association of eIF4E and SPARC Expression with Lymphangiogenesis and Lymph Node Metastasis in Hypopharyngeal Cancer.Anticancer Res2018 FebErnst BP-
27986751A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer.Clin Cancer Res2017 May 15Humphries MPdoi: 10.1158/1078-0432.CCR-16-1952
29254314Expression profile of eukaryotic translation initiation factor and matrix metalloproteinase 9 in endometrial cancer tissue.J Biol Regul Homeost Agents2017 Oct-DecShi ZM-
28661037AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression.J Cell Mol Med2017 DecWu Sdoi: 10.1111/jcmm.13258
27162083The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.Angew Chem Int Ed Engl2016 Jun 13Salvi Ndoi: 10.1002/anie.201603254
29342273Hypermethylation of EIF4E promoter is associated with early onset of gastric cancer.Carcinogenesis2018 Jan 12Ge Ydoi: 10.1093/carcin/bgx110.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr4989291195'UTRnovel0.41
BLCAchr498884943Missense_MutationnovelR173T0.13
BLCAchr498881111Missense_MutationNAP191A0.16
BRCAchr4989291575'UTRnovel0.09
BRCAchr4989292655'UTRnovel0.11
BRCAchr4988808513'UTRnovel0.33
CESCchr4988800523'UTRnovel0.43
CESCchr498887095Missense_Mutationrs776434815R128H0.14IF4E
CESCchr498891276Missense_MutationnovelR61Q0.17IF4E
CESCchr4988746603'UTRnovel0.64
COADchr4989291495'UTRrs7714652800.67
COADchr498901936Missense_Mutationrs772918368T22M0.37
COADchr4989291615'UTRNA0.22
COADchr498901950SilentNAT17T0.32
COADchr4988809553'UTRnovel0.08
COADchr498885008Silentrs185066219G151G0.09
COADchr4988809433'UTRnovel0.14
COADchr498901980Missense_MutationnovelE7D0.06
ESCAchr498884943Missense_MutationnovelR173K0.4
GBMchr498886988Intronnovel0.56
GBMchr498887132Missense_MutationnovelT116A0.46IF4E
HNSCchr498887905Missense_MutationnovelD90G0.3IF4E
KIRCchr498901962Missense_MutationNAN13K0.32
KIRPchr498887013Intronnovel0.29
KIRPchr4989291505'UTRnovel0.07
LGGchr498887002Intronnovel0.23
LGGchr498891255Missense_MutationnovelT68N0.42IF4E
LGGchr498891317Missense_MutationnovelF47L0.48IF4E
LIHCchr498928993Intronnovel0.11
LIHCchr498929101Silentrs764172724V4V0.26
LIHCchr498901917SilentnovelV28V0.83
LUADchr498891286Missense_MutationnovelA58P0.1IF4E
LUADchr4988809943'UTRnovel0.14
LUADchr498881114Missense_MutationNAP190S0.31
LUADchr498891315Missense_MutationnovelF48S0.1IF4E
LUADchr498887929Missense_MutationnovelS82C0.17IF4E
LUSCchr498901977SilentNAT8T0.19
LUSCchr498881104Missense_MutationnovelI193T0.19
OVchr498887029Intronnovel0.13
PRADchr498901940Missense_MutationnovelK21Q0.37
READchr498887020Intronnovel0.35
READchr498887099Missense_Mutationrs17850950D127N0.1IF4E
SKCMchr498887096Missense_MutationNAR128C0.42IF4E
SKCMchr498885035SilentNAF142F0.46
SKCMchr498886998Intronnovel0.26
SKCMchr498929071Intronnovel0.36
SKCMchr498887177Missense_MutationNAM101L0.32IF4E
STADchr498901930Missense_MutationNAS24C0.26
STADchr498887100SilentNAL126L0.38
STADchr498901950SilentNAT17T0.16
STADchr498891236Splice_SiteNAX74_splice0.31
TGCTchr498891278SilentnovelL60L0.19
UCECchr4988800113'UTRnovel0.43
UCECchr498928894Intronnovel0.33
UCECchr4988808783'UTRnovel0.32
UCECchr498887074Splice_Regionnovel0.08
UCECchr498891254SilentnovelT68T0.28
UCECchr4988745363'UTRnovel0.57
UCECchr4988746373'UTRnovel0.3
UCECchr498886964Intronnovel0.46
UCECchr498881058SilentNAG208G0.22
UCECchr4988801953'UTRnovel0.44
UCECchr4988800353'UTRnovel0.29
UCECchr4988808073'UTRnovel0.38
UCECchr498901907Nonsense_MutationnovelE32*0.33
UCECchr498901935Silentrs771705281T22T0.26
UCECchr498901907Nonsense_MutationnovelE32*0.19
UCECchr498881034SilentnovelV216V0.49
UCECchr498901881SilentnovelQ40Q0.34
UCECchr4988800983'UTRnovel0.4
UCECchr4988809733'UTRnovel0.21
UCECchr498885007Missense_MutationnovelA152T0.1
UCECchr498885015Missense_MutationnovelV149A0.39
UCECchr4989292775'UTRnovel0.36
UCECchr498887095Missense_Mutationrs776434815R128H0.15IF4E
UCECchr498886910Intronnovel0.5
UCECchr4988808793'UTRrs5317272140.42
UCECchr4988809283'UTRnovel0.35
UCECchr4988810063'UTRnovel0.33
UCSchr498901935Silentrs771705281T22T0.34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LIHCDEL0.43247.0927e-07
LUADDEL0.20160.050802
MESODEL0.40230.075661

Survival Analysis
CancerP-value Q-value
KIRC0.0009

Kaplan-Meier Survival Analysis

HNSC0.003

Kaplan-Meier Survival Analysis

SKCM0.01

Kaplan-Meier Survival Analysis

BRCA0.01

Kaplan-Meier Survival Analysis

COAD0.0072

Kaplan-Meier Survival Analysis

LAML0.0068

Kaplan-Meier Survival Analysis

UCEC0.0049

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

DLBC0.025

Kaplan-Meier Survival Analysis

LGG0.012

Kaplan-Meier Survival Analysis

LUAD0.0053

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000151247 (Gene tree)
Gene ID
1977
Gene Symbol
EIF4E
Alias
EIF4E1|EIF4EL1|EIF4F
Full Name
eukaryotic translation initiation factor 4E
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
58,954 bases
Position
chr4:98,871,684-98,930,637
Accession
3287
RBP type
canonical RBP
Summary
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000389624IF4EPF01652.181e-5511
ENSP00000280892IF4EPF01652.181.3e-5511
ENSP00000423977IF4EPF01652.181.3e-5511
ENSP00000425561IF4EPF01652.181.3e-4911
ENSP00000421287IF4EPF01652.189.3e-3311
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18631138Translational control in early development: CPEB, P-bodies and germinal granules.Biochem Soc Trans2008 AugStandart Ndoi: 10.1042/BST0360671.
22586079Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation.Proc Natl Acad Sci U S A2012 May 29Ma Jdoi: 10.1073/pnas.1120045109
18509338Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.Nature2008 Jul 3Wang Xdoi: 10.1038/nature06992
17942399CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.J Biol Chem2007 Dec 28Minshall N-
25463438Distinct features of cap binding by eIF4E1b proteins.J Mol Biol2015 Jan 30Kubacka Ddoi: 10.1016/j.jmb.2014.11.009
19114555Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.Mol Cell Biol2009 MarYanagiya Adoi: 10.1128/MCB.01187-08
21262214The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo.Dev Biol2011 Apr 1Singh Ndoi: 10.1016/j.ydbio.2011.01.017
11214172Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.RNA2001 JanDe Gregorio E-
10747998The phosphorylation state of poly(A)-binding protein specifies its binding to poly(A) RNA and its interaction with eukaryotic initiation factor (eIF) 4F, eIFiso4F, and eIF4B.J Biol Chem2000 Jun 9Le H-
15353001RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells.Mol Cancer2004 Sep 7Penalva LO-
21139564Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1PABP mRNPs in vivo.EMBO J2011 Jan 19Park EHdoi: 10.1038/emboj.2010.312
19414591Intrinsic RNA binding by the eukaryotic initiation factor 4F depends on a minimal RNA length but not on the m7G cap.J Biol Chem2009 Jun 26Kaye NMdoi: 10.1074/jbc.M109.009001
11416181Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome.Proc Natl Acad Sci U S A2001 Jun 19Keene JD-
22917528Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation.Behav Brain Res2012 Dec 1Gronli Jdoi: 10.1016/j.bbr.2012.08.008
22678294An oxygen-regulated switch in the protein synthesis machinery.Nature2012 May 6Uniacke Jdoi: 10.1038/nature11055.
22467875Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs.J Biol Chem2012 Jun 8Rajagopal Vdoi: 10.1074/jbc.M112.347278
25197831The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation.PLoS One2014 Sep 8Hu Gdoi: 10.1371/journal.pone.0107016
25110031eIF4E-binding proteins: new factors, new locations, new roles.Biochem Soc Trans2014 AugKamenska Adoi: 10.1042/BST20140063.
24895251Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).Int J Cancer2015 Oct 15Li-Weber Mdoi: 10.1002/ijc.29013
28251928Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.Proc Natl Acad Sci U S A2017 Mar 14Abbas YMdoi: 10.1073/pnas.1612444114
30591552Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression.Cancer Res2019 Feb 15Lucchesi CAdoi: 10.1158/0008-5472.CAN-18-2209
1611042Signal transduction and regulation of translation initiation.Semin Cell Biol1992 AprFrederickson RM-
9478191X-ray studies of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.Nucleic Acids Symp Ser1997Marcotrigiano J-
9200613Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.Cell1997 Jun 13Marcotrigiano J-
15860463Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice.J Gerontol A Biol Sci Med Sci2005 MarSharp ZD-
19835415How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model.Biochemistry2009 Nov 17Spirin ASdoi: 10.1021/bi901379a.
18692164Effects of poly(A)-binding protein on the interactions of translation initiation factor eIF4F and eIF4F.4B with internal ribosome entry site (IRES) of tobacco etch virus RNA.Biochim Biophys Acta2008 OctKhan MAdoi: 10.1016/j.bbagrm.2008.07.004
18643965Plant stress granules and mRNA processing bodies are distinct from heat stress granules.Plant J2008 NovWeber Cdoi: 10.1111/j.1365-313X.2008.03623.x
18005740Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions.Cell Host Microbe2007 Oct 11Katsafanas GC-
20659017Inhibition of translation initiation following glucose depletion in yeast facilitates a rationalization of mRNA content.Biochem Soc Trans2010 AugLui Jdoi: 10.1042/BST0381131.
24909168Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.Oncogene2015 Apr 16Robichaud Ndoi: 10.1038/onc.2014.146
28287067Translational control of mRNAs by 3'-Untranslated region binding proteins.BMB Rep2017 AprYamashita A-
9548260Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.Nature1998 Apr 2Craig AW-
24728987Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions.Nucleic Acids Res2014 JunKhan MAdoi: 10.1093/nar/gku248
17095505Picornavirus internal ribosome entry site elements can stimulate translation of upstream genes.J Biol Chem2007 Jan 5Junemann C-
25100834The 3' untranslated region of Pea Enation Mosaic Virus contains two T-shaped, ribosome-binding, cap-independent translation enhancers.J Virol2014 OctGao Fdoi: 10.1128/JVI.01433-14
23604114STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.Oncogene2014 Mar 27Pawlus MRdoi: 10.1038/onc.2013.115
18977752Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc.J Biol Chem2008 Dec 26Cheng Sdoi: 10.1074/jbc.M807716200
18369981Efficient 5' cap-dependent RNA purification : use in identifying and studying subsets of RNA.Methods Mol Biol2008Bajak EZdoi: 10.1007/978-1-59745-033-1_10.
17226766Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.J Cell Biochem2007 Aug 1Shin S-
21645857The cap-binding translation initiation factor, eIF4E, binds a pseudoknot in a viral cap-independent translation element.Structure2011 Jun 8Wang Zdoi: 10.1016/j.str.2011.03.013.
11723111Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.J Biol Chem2002 Feb 1Scheper GC-
21402597Cellular cap-binding proteins associate with influenza virus mRNAs.J Gen Virol2011 JulBier Kdoi: 10.1099/vir.0.029231-0
9372919Binding of eukaryotic translation initiation factor 4E (eIF4E) to eIF4G represses translation of uncapped mRNA.Mol Cell Biol1997 DecTarun SZ Jr-
12709531Gene regulation at the RNA layer: RNA binding proteins in intercellular signaling networks.Sci STKE2003 Apr 22Lasko P-
15694484Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues.Mol Biochem Parasitol2005 MarDhalia R-
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Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000418385EIF4E-202574--- (aa)--
ENST00000504432EIF4E-2041132-ENSP00000423977245 (aa)-D6RBW1
ENST00000450253EIF4E-20311523-ENSP00000389624217 (aa)-P06730
ENST00000505194EIF4E-206563--- (aa)--
ENST00000504472EIF4E-205588--- (aa)--
ENST00000511644EIF4E-210686-ENSP00000421287155 (aa)-H0Y8J7
ENST00000280892EIF4E-2011097-ENSP00000280892237 (aa)-P06730
ENST00000505992EIF4E-208898-ENSP00000425561248 (aa)-P06730
ENST00000505829EIF4E-207429--- (aa)--
ENST00000507665EIF4E-2091143--- (aa)--
ENST00000515638EIF4E-211738-ENSP0000042660242 (aa)-D6RFJ3
Gene Model
Click here to download ENSG00000151247's gene model file
Pathways
Pathway IDPathway NameSource
hsa01521EGFR tyrosine kinase inhibitor resistanceKEGG
hsa03013RNA transportKEGG
hsa04066HIF-1 signaling pathwayKEGG
hsa04150mTOR signaling pathwayKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04211Longevity regulating pathwayKEGG
hsa04910Insulin signaling pathwayKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000151247rs199646819498927473AMenopause (age at onset)29773799[0.091-0.209] year increase0.15EFO_0004704
ENSG00000151247rs7665590498875633GPrimary biliary cholangitis23000144[1.21-1.52]1.35EFO_0004267
ENSG00000151247rs62323189498874312TSelf-reported math ability30038396[0.0077-0.0163] unit increase0.012EFO_0004875
ENSG00000151247rs199646819498927473AMenopause (age at onset)29773799EFO_0004704
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000151247's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000151247EIF4E6531.068ENSG00000163412EIF4E39031.818
ENSG00000151247EIF4E9232.857ENSG00000135930EIF4E27834.503
ENSG00000151247EIF4E8374.033ENSG00000175766EIF4E1B7574.033
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000151247EIF4E10083.028ENSAPOG00000006396EIF4E7487.692Acanthochromis_polyacanthus
ENSG00000151247EIF4E10082.569ENSAPOG00000019698eif4ea8989.062Acanthochromis_polyacanthus
ENSG00000151247EIF4E9998.140ENSAMEG00000013873EIF4E10098.140Ailuropoda_melanoleuca
ENSG00000151247EIF4E9277.612ENSACIG00000021637eif4ea9787.611Amphilophus_citrinellus
ENSG00000151247EIF4E10083.871ENSACIG00000011004eif4eb9087.179Amphilophus_citrinellus
ENSG00000151247EIF4E10082.110ENSAOCG00000020871eif4ea8988.021Amphiprion_ocellaris
ENSG00000151247EIF4E9584.541ENSAOCG00000006816eif4eb8287.692Amphiprion_ocellaris
ENSG00000151247EIF4E10082.110ENSAPEG00000001758eif4ea9790.857Amphiprion_percula
ENSG00000151247EIF4E10083.410ENSAPEG00000016986eif4eb8387.692Amphiprion_percula
ENSG00000151247EIF4E10081.106ENSATEG00000003645eif4ea8988.021Anabas_testudineus
ENSG00000151247EIF4E10083.410ENSATEG00000008860eif4eb9087.179Anabas_testudineus
ENSG00000151247EIF4E9893.023ENSAPLG00000015915EIF4E9195.477Anas_platyrhynchos
ENSG00000151247EIF4E10094.064ENSACAG00000014186EIF4E10092.166Anolis_carolinensis
ENSG00000151247EIF4E10099.078ENSANAG00000021761-10099.078Aotus_nancymaae
ENSG00000151247EIF4E10093.548ENSANAG00000035121-9793.548Aotus_nancymaae
ENSG00000151247EIF4E10092.857ENSANAG00000026335-9183.410Aotus_nancymaae
ENSG00000151247EIF4E9084.211ENSANAG00000018148-8662.755Aotus_nancymaae
ENSG00000151247EIF4E9485.366ENSACLG00000009996eif4ea7989.005Astatotilapia_calliptera
ENSG00000151247EIF4E10083.410ENSACLG00000022252eif4eb9087.179Astatotilapia_calliptera
ENSG00000151247EIF4E10082.110ENSAMXG00000041156eif4eb8686.667Astyanax_mexicanus
ENSG00000151247EIF4E9383.333ENSAMXG00000038623eif4ea8886.458Astyanax_mexicanus
ENSG00000151247EIF4E10099.539ENSBTAG00000009522EIF4E10099.539Bos_taurus
ENSG00000151247EIF4E10095.238ENSCJAG00000042502-10081.106Callithrix_jacchus
ENSG00000151247EIF4E10099.078ENSCJAG00000007151-10099.078Callithrix_jacchus
ENSG00000151247EIF4E9899.057ENSCAFG00000010307EIF4E9899.057Canis_familiaris
ENSG00000151247EIF4E61100.000ENSCAFG00020003381-100100.000Canis_lupus_dingo
ENSG00000151247EIF4E10073.733ENSCAFG00020005788-8873.096Canis_lupus_dingo
ENSG00000151247EIF4E10099.539ENSCHIG00000009550-10099.539Capra_hircus
ENSG00000151247EIF4E10069.048ENSCHIG00000015439-8962.626Capra_hircus
ENSG00000151247EIF4E10099.078ENSTSYG00000010862EIF4E10099.078Carlito_syrichta
ENSG00000151247EIF4E9798.578ENSCAPG00000007055EIF4E10098.578Cavia_aperea
ENSG00000151247EIF4E10098.618ENSCPOG00000032402EIF4E10098.618Cavia_porcellus
ENSG00000151247EIF4E6173.485ENSCCAG00000030617-10073.485Cebus_capucinus
ENSG00000151247EIF4E10099.078ENSCCAG00000028844-10099.078Cebus_capucinus
ENSG00000151247EIF4E10099.539ENSCATG00000037138EIF4E10099.539Cercocebus_atys
ENSG00000151247EIF4E9798.578ENSCLAG00000004478EIF4E10099.242Chinchilla_lanigera
ENSG00000151247EIF4E100100.000ENSCSAG00000004122EIF4E100100.000Chlorocebus_sabaeus
ENSG00000151247EIF4E8183.429ENSCHOG00000009450EIF4E10083.429Choloepus_hoffmanni
ENSG00000151247EIF4E10093.607ENSCPBG00000016145EIF4E10091.705Chrysemys_picta_bellii
ENSG00000151247EIF4E9956.054ENSCSAVG00000011078-8461.224Ciona_savignyi
ENSG00000151247EIF4E100100.000ENSCANG00000037561-100100.000Colobus_angolensis_palliatus
ENSG00000151247EIF4E6172.727ENSCANG00000029719-10072.727Colobus_angolensis_palliatus
ENSG00000151247EIF4E10065.438ENSCGRG00001010956-9068.063Cricetulus_griseus_chok1gshd
ENSG00000151247EIF4E10085.714ENSCGRG00001024329-10081.106Cricetulus_griseus_chok1gshd
ENSG00000151247EIF4E10085.714ENSCGRG00001012785-10081.567Cricetulus_griseus_chok1gshd
ENSG00000151247EIF4E8199.429ENSCGRG00001012870-10099.429Cricetulus_griseus_chok1gshd
ENSG00000151247EIF4E10085.714ENSCGRG00001023344-9078.846Cricetulus_griseus_chok1gshd
ENSG00000151247EIF4E10085.714ENSCGRG00000001975-9078.846Cricetulus_griseus_crigri
ENSG00000151247EIF4E9997.222ENSCGRG00000000305-10098.104Cricetulus_griseus_crigri
ENSG00000151247EIF4E10085.714ENSCGRG00000011293-10081.567Cricetulus_griseus_crigri
ENSG00000151247EIF4E10065.899ENSCGRG00000003497-9068.586Cricetulus_griseus_crigri
ENSG00000151247EIF4E10085.714ENSCGRG00000014054-10081.567Cricetulus_griseus_crigri
ENSG00000151247EIF4E10081.567ENSCSEG00000000097eif4eb8486.667Cynoglossus_semilaevis
ENSG00000151247EIF4E10082.028ENSCSEG00000003535eif4ea9087.113Cynoglossus_semilaevis
ENSG00000151247EIF4E9783.886ENSCVAG00000017533eif4eb8788.718Cyprinodon_variegatus
ENSG00000151247EIF4E9981.308ENSCVAG00000002085eif4ea9286.667Cyprinodon_variegatus
ENSG00000151247EIF4E10082.488ENSDARG00000077012eif4ea9186.667Danio_rerio
ENSG00000151247EIF4E10084.862ENSDARG00000013274eif4eb9089.744Danio_rerio
ENSG00000151247EIF4E9799.526ENSDNOG00000013712EIF4E9899.057Dasypus_novemcinctus
ENSG00000151247EIF4E10099.539ENSDORG00000002901Eif4e10099.539Dipodomys_ordii
ENSG00000151247EIF4E9892.683ENSETEG00000007347EIF4E10081.567Echinops_telfairi
ENSG00000151247EIF4E8170.857ENSEBUG00000002799-8570.857Eptatretus_burgeri
ENSG00000151247EIF4E10099.078ENSEASG00005010796EIF4E10099.078Equus_asinus_asinus
ENSG00000151247EIF4E10099.078ENSECAG00000006472EIF4E10099.078Equus_caballus
ENSG00000151247EIF4E10081.193ENSELUG00000021129eif4ea9085.052Esox_lucius
ENSG00000151247EIF4E10080.734ENSELUG00000013924eif4eb8985.052Esox_lucius
ENSG00000151247EIF4E6288.462ENSFCAG00000034315-5181.538Felis_catus
ENSG00000151247EIF4E10099.078ENSFCAG00000009949-10099.078Felis_catus
ENSG00000151247EIF4E9993.056ENSFALG00000006190EIF4E9195.980Ficedula_albicollis
ENSG00000151247EIF4E10095.238ENSFDAG00000007715-10073.733Fukomys_damarensis
ENSG00000151247EIF4E9798.578ENSFDAG00000006384EIF4E9998.113Fukomys_damarensis
ENSG00000151247EIF4E10079.724ENSFHEG00000008111eif4ea9086.458Fundulus_heteroclitus
ENSG00000151247EIF4E10082.949ENSFHEG00000004270eif4eb9086.667Fundulus_heteroclitus
ENSG00000151247EIF4E9477.404ENSGMOG00000012412eif4ea8982.723Gadus_morhua
ENSG00000151247EIF4E10093.607ENSGALG00000042112EIF4E10092.166Gallus_gallus
ENSG00000151247EIF4E9574.396ENSGAFG00000012679eif4eb6687.975Gambusia_affinis
ENSG00000151247EIF4E9484.390ENSGAFG00000016825eif4ea8988.021Gambusia_affinis
ENSG00000151247EIF4E10081.567ENSGACG00000005536eif4eb9085.128Gasterosteus_aculeatus
ENSG00000151247EIF4E9581.731ENSGACG00000016472eif4ea8985.938Gasterosteus_aculeatus
ENSG00000151247EIF4E10093.607ENSGAGG00000020894-10091.705Gopherus_agassizii
ENSG00000151247EIF4E100100.000ENSGGOG00000004718EIF4E100100.000Gorilla_gorilla
ENSG00000151247EIF4E10088.095ENSGGOG00000022832-10070.968Gorilla_gorilla
ENSG00000151247EIF4E9986.047ENSGGOG00000036744-9087.374Gorilla_gorilla
ENSG00000151247EIF4E10097.619ENSGGOG00000037188-10095.392Gorilla_gorilla
ENSG00000151247EIF4E10083.410ENSHBUG00000004455eif4eb9087.179Haplochromis_burtoni
ENSG00000151247EIF4E9485.366ENSHBUG00000023862eif4ea7989.005Haplochromis_burtoni
ENSG00000151247EIF4E10098.618ENSHGLG00000005432-10098.618Heterocephalus_glaber_female
ENSG00000151247EIF4E9882.927ENSHGLG00000012940-10067.742Heterocephalus_glaber_female
ENSG00000151247EIF4E10091.705ENSHGLG00000020417-10091.705Heterocephalus_glaber_female
ENSG00000151247EIF4E10080.952ENSHGLG00000001482-10079.724Heterocephalus_glaber_female
ENSG00000151247EIF4E10076.498ENSHGLG00000009694-8492.763Heterocephalus_glaber_female
ENSG00000151247EIF4E10088.095ENSHGLG00000002642-8990.667Heterocephalus_glaber_female
ENSG00000151247EIF4E10088.940ENSHGLG00100002928-10088.940Heterocephalus_glaber_male
ENSG00000151247EIF4E10080.952ENSHGLG00100005548-10062.212Heterocephalus_glaber_male
ENSG00000151247EIF4E10088.095ENSHGLG00100000636-8990.667Heterocephalus_glaber_male
ENSG00000151247EIF4E6196.212ENSHGLG00100019753-10096.212Heterocephalus_glaber_male
ENSG00000151247EIF4E9572.500ENSHGLG00100001119-10063.594Heterocephalus_glaber_male
ENSG00000151247EIF4E10098.618ENSHGLG00100000337-10099.242Heterocephalus_glaber_male
ENSG00000151247EIF4E10090.476ENSHGLG00100018835-10075.576Heterocephalus_glaber_male
ENSG00000151247EIF4E9283.417ENSHCOG00000013033EIF4E9685.938Hippocampus_comes
ENSG00000151247EIF4E10081.567ENSHCOG00000008501eif4ea9585.714Hippocampus_comes
ENSG00000151247EIF4E10081.567ENSIPUG00000007404eif4eb6686.154Ictalurus_punctatus
ENSG00000151247EIF4E10079.817ENSIPUG00000003156eif4ea8982.990Ictalurus_punctatus
ENSG00000151247EIF4E10099.539ENSSTOG00000002230EIF4E10099.539Ictidomys_tridecemlineatus
ENSG00000151247EIF4E10077.419ENSJJAG00000023428-10077.419Jaculus_jaculus
ENSG00000151247EIF4E10097.619ENSJJAG00000024105-10098.883Jaculus_jaculus
ENSG00000151247EIF4E10097.619ENSJJAG00000020659-10076.037Jaculus_jaculus
ENSG00000151247EIF4E7979.532ENSJJAG00000016761-8379.532Jaculus_jaculus
ENSG00000151247EIF4E10080.734ENSKMAG00000010510eif4ea8986.979Kryptolebias_marmoratus
ENSG00000151247EIF4E10076.695ENSKMAG00000006541eif4eb9378.414Kryptolebias_marmoratus
ENSG00000151247EIF4E10079.724ENSLBEG00000015557eif4ea8986.979Labrus_bergylta
ENSG00000151247EIF4E8885.938ENSLBEG00000020676eif4eb9985.938Labrus_bergylta
ENSG00000151247EIF4E9591.827ENSLACG00000008977EIF4E9193.939Latimeria_chalumnae
ENSG00000151247EIF4E10087.615ENSLOCG00000012198-9289.899Lepisosteus_oculatus
ENSG00000151247EIF4E10098.618ENSLAFG00000002450EIF4E10098.618Loxodonta_africana
ENSG00000151247EIF4E10078.571ENSMFAG00000044259-9969.444Macaca_fascicularis
ENSG00000151247EIF4E100100.000ENSMFAG00000041112EIF4E100100.000Macaca_fascicularis
ENSG00000151247EIF4E10078.571ENSMMUG00000044965-9969.444Macaca_mulatta
ENSG00000151247EIF4E100100.000ENSMMUG00000011066EIF4E100100.000Macaca_mulatta
ENSG00000151247EIF4E100100.000ENSMNEG00000013566-100100.000Macaca_nemestrina
ENSG00000151247EIF4E6068.702ENSMNEG00000041253-9868.702Macaca_nemestrina
ENSG00000151247EIF4E10078.571ENSMLEG00000019103-9968.981Mandrillus_leucophaeus
ENSG00000151247EIF4E10099.156ENSMLEG00000021575EIF4E10099.156Mandrillus_leucophaeus
ENSG00000151247EIF4E10083.871ENSMAMG00000012438eif4eb8989.714Mastacembelus_armatus
ENSG00000151247EIF4E9584.541ENSMAMG00000017620eif4ea8186.802Mastacembelus_armatus
ENSG00000151247EIF4E9485.366ENSMZEG00005001254eif4ea8988.542Maylandia_zebra
ENSG00000151247EIF4E10083.410ENSMZEG00005007328eif4eb9087.179Maylandia_zebra
ENSG00000151247EIF4E9594.258ENSMGAG00000011171EIF4E9295.477Meleagris_gallopavo
ENSG00000151247EIF4E10088.095ENSMAUG00000014784-9282.759Mesocricetus_auratus
ENSG00000151247EIF4E8169.714ENSMAUG00000007913Eif4e10072.956Mesocricetus_auratus
ENSG00000151247EIF4E10099.539ENSMICG00000001482EIF4E10099.539Microcebus_murinus
ENSG00000151247EIF4E9192.893ENSMICG00000029015-9992.627Microcebus_murinus
ENSG00000151247EIF4E10097.696ENSMOCG00000016783Eif4e10097.696Microtus_ochrogaster
ENSG00000151247EIF4E10078.440ENSMMOG00000004159eif4ea8886.387Mola_mola
ENSG00000151247EIF4E8586.957ENSMMOG00000002503eif4eb9386.957Mola_mola
ENSG00000151247EIF4E5961.417ENSMMOG00000004160eif4ea7361.417Mola_mola
ENSG00000151247EIF4E9896.714ENSMODG00000020716EIF4E9196.714Monodelphis_domestica
ENSG00000151247EIF4E10082.028ENSMALG00000009588eif4eb9086.154Monopterus_albus
ENSG00000151247EIF4E9980.930ENSMALG00000009112eif4ea9087.113Monopterus_albus
ENSG00000151247EIF4E10097.696MGP_CAROLIEiJ_G0025684Eif4e10097.696Mus_caroli
ENSG00000151247EIF4E10098.157ENSMUSG00000028156Eif4e10099.242Mus_musculus
ENSG00000151247EIF4E10098.810MGP_PahariEiJ_G0027133-10098.936Mus_pahari
ENSG00000151247EIF4E9998.131MGP_SPRETEiJ_G0026639Eif4e9498.131Mus_spretus
ENSG00000151247EIF4E10099.078ENSMPUG00000019106-10099.078Mustela_putorius_furo
ENSG00000151247EIF4E9197.990ENSMPUG00000002041-9897.196Mustela_putorius_furo
ENSG00000151247EIF4E9192.386ENSMLUG00000029353-9192.386Myotis_lucifugus
ENSG00000151247EIF4E9197.970ENSMLUG00000005035EIF4E9797.156Myotis_lucifugus
ENSG00000151247EIF4E10097.696ENSNGAG00000018806-10097.696Nannospalax_galili
ENSG00000151247EIF4E6073.282ENSNGAG00000010965-7294.286Nannospalax_galili
ENSG00000151247EIF4E5172.321ENSNBRG00000023589-9472.321Neolamprologus_brichardi
ENSG00000151247EIF4E10057.143ENSNBRG00000009453eif4eb7184.615Neolamprologus_brichardi
ENSG00000151247EIF4E9484.878ENSNBRG00000014676eif4ea9187.435Neolamprologus_brichardi
ENSG00000151247EIF4E5487.179ENSNBRG00000009441eif4eb10087.179Neolamprologus_brichardi
ENSG00000151247EIF4E10085.714ENSNLEG00000032897-10059.821Nomascus_leucogenys
ENSG00000151247EIF4E10095.238ENSNLEG00000008242-10082.028Nomascus_leucogenys
ENSG00000151247EIF4E10083.966ENSNLEG00000014006-9799.515Nomascus_leucogenys
ENSG00000151247EIF4E8198.857ENSMEUG00000011104-10098.857Notamacropus_eugenii
ENSG00000151247EIF4E10083.410ENSOPRG00000002289EIF4E10083.410Ochotona_princeps
ENSG00000151247EIF4E10097.696ENSODEG00000001981-10097.696Octodon_degus
ENSG00000151247EIF4E10090.476ENSODEG00000003254-10088.940Octodon_degus
ENSG00000151247EIF4E9969.907ENSODEG00000003786-8470.558Octodon_degus
ENSG00000151247EIF4E6181.955ENSODEG00000017723-10081.955Octodon_degus
ENSG00000151247EIF4E9486.341ENSONIG00000001077eif4ea7989.583Oreochromis_niloticus
ENSG00000151247EIF4E10083.410ENSONIG00000019485eif4eb9087.179Oreochromis_niloticus
ENSG00000151247EIF4E8393.023ENSOANG00000009633EIF4E8896.875Ornithorhynchus_anatinus
ENSG00000151247EIF4E9970.046ENSOANG00000013092-8378.571Ornithorhynchus_anatinus
ENSG00000151247EIF4E9997.685ENSOCUG00000001456EIF4E8597.685Oryctolagus_cuniculus
ENSG00000151247EIF4E9979.630ENSORLG00000020641eif4ea7385.492Oryzias_latipes
ENSG00000151247EIF4E10080.645ENSORLG00000017636eif4eb9086.667Oryzias_latipes
ENSG00000151247EIF4E10079.263ENSORLG00020007626eif4ea9185.052Oryzias_latipes_hni
ENSG00000151247EIF4E9088.205ENSORLG00020017089eif4eb9088.205Oryzias_latipes_hni
ENSG00000151247EIF4E9087.692ENSORLG00015013662eif4eb9087.692Oryzias_latipes_hsok
ENSG00000151247EIF4E9979.630ENSORLG00015016545eif4ea7385.492Oryzias_latipes_hsok
ENSG00000151247EIF4E10083.871ENSOMEG00000012006eif4eb7688.718Oryzias_melastigma
ENSG00000151247EIF4E10078.802ENSOMEG00000011486eif4ea9576.786Oryzias_melastigma
ENSG00000151247EIF4E10098.157ENSOGAG00000028084-10098.157Otolemur_garnettii
ENSG00000151247EIF4E9189.394ENSOGAG00000001131-9189.394Otolemur_garnettii
ENSG00000151247EIF4E10099.539ENSOARG00000015905EIF4E10099.539Ovis_aries
ENSG00000151247EIF4E10099.593ENSPPAG00000043652-100100.000Pan_paniscus
ENSG00000151247EIF4E9982.326ENSPPAG00000036513-9079.695Pan_paniscus
ENSG00000151247EIF4E10099.078ENSPPRG00000019904-10099.078Panthera_pardus
ENSG00000151247EIF4E10083.721ENSPPRG00000010794-5987.037Panthera_pardus
ENSG00000151247EIF4E10085.714ENSPPRG00000005033-8389.041Panthera_pardus
ENSG00000151247EIF4E10099.078ENSPTIG00000012109EIF4E10099.078Panthera_tigris_altaica
ENSG00000151247EIF4E10085.714ENSPTIG00000008243-8389.041Panthera_tigris_altaica
ENSG00000151247EIF4E100100.000ENSPTRG00000016301EIF4E100100.000Pan_troglodytes
ENSG00000151247EIF4E10090.476ENSPTRG00000047631-10070.046Pan_troglodytes
ENSG00000151247EIF4E9983.256ENSPTRG00000050078-8584.343Pan_troglodytes
ENSG00000151247EIF4E6067.939ENSPANG00000032953-9867.939Papio_anubis
ENSG00000151247EIF4E10098.734ENSPANG00000029352-10098.734Papio_anubis
ENSG00000151247EIF4E5482.051ENSPKIG00000018294-10082.051Paramormyrops_kingsleyae
ENSG00000151247EIF4E9781.991ENSPKIG00000000226eif4ea8987.113Paramormyrops_kingsleyae
ENSG00000151247EIF4E10093.607ENSPSIG00000018060EIF4E10091.705Pelodiscus_sinensis
ENSG00000151247EIF4E9088.205ENSPMGG00000022663eif4eb9988.205Periophthalmus_magnuspinnatus
ENSG00000151247EIF4E10081.106ENSPMGG00000021723eif4ea9087.435Periophthalmus_magnuspinnatus
ENSG00000151247EIF4E10098.157ENSPEMG00000023956-10099.242Peromyscus_maniculatus_bairdii
ENSG00000151247EIF4E10077.880ENSPEMG00000021846-10077.880Peromyscus_maniculatus_bairdii
ENSG00000151247EIF4E7977.236ENSPMAG00000001359-7682.895Petromyzon_marinus
ENSG00000151247EIF4E10097.235ENSPCIG00000020928EIF4E10097.235Phascolarctos_cinereus
ENSG00000151247EIF4E10083.410ENSPFOG00000000233eif4eb8387.692Poecilia_formosa
ENSG00000151247EIF4E9484.390ENSPFOG00000019121eif4ea8988.021Poecilia_formosa
ENSG00000151247EIF4E9585.507ENSPLAG00000020574eif4eb9087.692Poecilia_latipinna
ENSG00000151247EIF4E9982.028ENSPLAG00000014990eif4ea9088.021Poecilia_latipinna
ENSG00000151247EIF4E9484.390ENSPMEG00000009268eif4ea8988.021Poecilia_mexicana
ENSG00000151247EIF4E9570.048ENSPMEG00000016989eif4eb9171.282Poecilia_mexicana
ENSG00000151247EIF4E10083.871ENSPREG00000002433eif4eb9988.827Poecilia_reticulata
ENSG00000151247EIF4E9484.390ENSPREG00000010442eif4ea8988.021Poecilia_reticulata
ENSG00000151247EIF4E81100.000ENSPPYG00000014944-97100.000Pongo_abelii
ENSG00000151247EIF4E9289.000ENSPCAG00000002392EIF4E9388.832Procavia_capensis
ENSG00000151247EIF4E7385.088ENSPCOG00000010012-9884.348Propithecus_coquereli
ENSG00000151247EIF4E10076.190ENSPCOG00000025451-8968.342Propithecus_coquereli
ENSG00000151247EIF4E9182.828ENSPVAG00000011253EIF4E9383.249Pteropus_vampyrus
ENSG00000151247EIF4E9683.654ENSPNYG00000003896eif4eb8887.179Pundamilia_nyererei
ENSG00000151247EIF4E9485.366ENSPNYG00000020891eif4ea8988.542Pundamilia_nyererei
ENSG00000151247EIF4E7288.393ENSPNAG00000003597-8288.393Pygocentrus_nattereri
ENSG00000151247EIF4E8382.222ENSPNAG00000015574eif4eb8978.689Pygocentrus_nattereri
ENSG00000151247EIF4E10098.157ENSRNOG00000052343Eif4e10098.157Rattus_norvegicus
ENSG00000151247EIF4E10078.571ENSRBIG00000029493-10061.751Rhinopithecus_bieti
ENSG00000151247EIF4E100100.000ENSRBIG00000039027-100100.000Rhinopithecus_bieti
ENSG00000151247EIF4E100100.000ENSRROG00000034046-100100.000Rhinopithecus_roxellana
ENSG00000151247EIF4E10078.571ENSRROG00000038555-10061.751Rhinopithecus_roxellana
ENSG00000151247EIF4E10099.078ENSSBOG00000029564EIF4E10099.078Saimiri_boliviensis_boliviensis
ENSG00000151247EIF4E9995.833ENSSHAG00000008442EIF4E10095.833Sarcophilus_harrisii
ENSG00000151247EIF4E10084.862ENSSFOG00015002887eif4ea9089.175Scleropages_formosus
ENSG00000151247EIF4E10079.724ENSSMAG00000010015eif4ea8986.458Scophthalmus_maximus
ENSG00000151247EIF4E10080.734ENSSMAG00000010796eif4eb9286.667Scophthalmus_maximus
ENSG00000151247EIF4E10081.651ENSSDUG00000002220eif4ea8987.500Seriola_dumerili
ENSG00000151247EIF4E10084.332ENSSDUG00000013967eif4eb9486.885Seriola_dumerili
ENSG00000151247EIF4E10083.871ENSSLDG00000005749eif4eb7487.692Seriola_lalandi_dorsalis
ENSG00000151247EIF4E10081.651ENSSLDG00000023001eif4ea8987.500Seriola_lalandi_dorsalis
ENSG00000151247EIF4E8299.213ENSSARG00000007821EIF4E78100.000Sorex_araneus
ENSG00000151247EIF4E10093.607ENSSPUG00000014306EIF4E10091.705Sphenodon_punctatus
ENSG00000151247EIF4E10083.410ENSSPAG00000008899eif4eb8187.179Stegastes_partitus
ENSG00000151247EIF4E9585.096ENSSPAG00000005937eif4ea8988.542Stegastes_partitus
ENSG00000151247EIF4E10099.078ENSSSCG00000028420EIF4E10099.078Sus_scrofa
ENSG00000151247EIF4E9993.981ENSTGUG00000003296EIF4E9295.980Taeniopygia_guttata
ENSG00000151247EIF4E10082.488ENSTRUG00000000960eif4eb8987.692Takifugu_rubripes
ENSG00000151247EIF4E9582.212ENSTRUG00000024250eif4ea8385.567Takifugu_rubripes
ENSG00000151247EIF4E10081.567ENSTNIG00000005642eif4eb9086.667Tetraodon_nigroviridis
ENSG00000151247EIF4E9971.429ENSTNIG00000013021eif4ea9075.773Tetraodon_nigroviridis
ENSG00000151247EIF4E9180.711ENSTBEG00000015375EIF4E82100.000Tupaia_belangeri
ENSG00000151247EIF4E9799.052ENSTTRG00000004206EIF4E10099.052Tursiops_truncatus
ENSG00000151247EIF4E10097.619ENSUAMG00000013297EIF4E100100.000Ursus_americanus
ENSG00000151247EIF4E10099.539ENSUMAG00000004901EIF4E10099.539Ursus_maritimus
ENSG00000151247EIF4E9798.578ENSVPAG00000006072EIF4E10098.113Vicugna_pacos
ENSG00000151247EIF4E9897.561ENSVVUG00000007754-6184.332Vulpes_vulpes
ENSG00000151247EIF4E10092.857ENSVVUG00000023056-9087.097Vulpes_vulpes
ENSG00000151247EIF4E10089.401ENSXETG00000009316eif4e9291.878Xenopus_tropicalis
ENSG00000151247EIF4E9260.697ENSXETG00000019631eif4e1b9260.396Xenopus_tropicalis
ENSG00000151247EIF4E8988.144ENSXCOG00000013737eif4eb10088.144Xiphophorus_couchianus
ENSG00000151247EIF4E9484.390ENSXCOG00000014847eif4ea8788.021Xiphophorus_couchianus
ENSG00000151247EIF4E10081.193ENSXMAG00000002337eif4ea8988.482Xiphophorus_maculatus
ENSG00000151247EIF4E8988.144ENSXMAG00000015293eif4eb10088.144Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000082G1/S transition of mitotic cell cycle14673156.IMPProcess
GO:0000339RNA cap binding3469651.TASFunction
GO:0000340RNA 7-methylguanosine cap binding21873635.IBAFunction
GO:0000340RNA 7-methylguanosine cap binding19750007.IDAFunction
GO:0000932P-body20616046.IDAComponent
GO:0001662behavioral fear response-IEAProcess
GO:0003723RNA binding22681889.HDAFunction
GO:0003743translation initiation factor activity21873635.IBAFunction
GO:0003743translation initiation factor activity22578813.IDAFunction
GO:0003743translation initiation factor activity-ISSFunction
GO:0005515protein binding7651417.10772338.10856257.15153109.15247416.15361857.16189514.16271312.16467844.16504179.16699599.16739988.18955708.19060904.19262567.19834456.20212144.20224576.20430826.20616046.20880835.20927323.21191102.22678294.23665581.23788676.24207126.24211447.25416956.27065194.29358667.IPIFunction
GO:0005737cytoplasm19393246.23814182.IDAComponent
GO:0005829cytosol19750007.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005845mRNA cap binding complex16271312.IDAComponent
GO:0006405RNA export from nucleus-TASProcess
GO:0006406mRNA export from nucleus-TASProcess
GO:0006413translational initiation-TASProcess
GO:0006417regulation of translation22578813.IDAProcess
GO:0010494cytoplasmic stress granule21883093.IDAComponent
GO:0010507negative regulation of autophagy18426977.IMPProcess
GO:0016032viral process-IEAProcess
GO:0016281eukaryotic translation initiation factor 4F complex21873635.IBAComponent
GO:0016281eukaryotic translation initiation factor 4F complex22578813.IDAComponent
GO:0016442RISC complex20616046.IDAComponent
GO:0017148negative regulation of translation-IEAProcess
GO:0019827stem cell population maintenance-IEAProcess
GO:0019899enzyme binding23814182.IDAFunction
GO:0030324lung development-IEAProcess
GO:0031370eukaryotic initiation factor 4G binding18337562.23814182.IDAFunction
GO:0033391chromatoid body-IEAComponent
GO:0036464cytoplasmic ribonucleoprotein granule-IDAComponent
GO:0045665negative regulation of neuron differentiation-IEAProcess
GO:0045931positive regulation of mitotic cell cycle14673156.IMPProcess
GO:0048471perinuclear region of cytoplasm23814182.IDAComponent
GO:0070062extracellular exosome20458337.HDAComponent
GO:0070491repressing transcription factor binding23814182.IDAFunction
GO:0071549cellular response to dexamethasone stimulus-IEAProcess
GO:0098978glutamatergic synapse-IEAComponent
GO:0099524postsynaptic cytosol-IEAComponent
GO:0099578regulation of translation at postsynapse, modulating synaptic transmission-IEAProcess
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