EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20358297	ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer.	Mol Biol Rep	2011 Jan	Akisik E	doi: 10.1007/s11033-010-0113-3
18375053	ARLTS1 - a novel tumor suppressor gene.	Cancer Lett	2008 Jun 8	Yendamuri S	doi: 10.1016/j.canlet.2008.02.021
16570116	Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene.	Breast Cancer Res Treat	2006 Sep	Masojc B	-
15843669	Familial cancer associated with a polymorphism in ARLTS1.	N Engl J Med	2005 Apr 21	Calin GA	-
18337727	ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer.	Eur J Hum Genet	2008 Aug	Siltanen S	doi: 10.1038/ejhg.2008.43
22028916	Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells.	PLoS One	2011	Siltanen S	doi: 10.1371/journal.pone.0026595
20067102	[Polymorphism of ARLTS1 gene in early-onset ovarian cancer].	Sichuan Da Xue Xue Bao Yi Xue Ban	2009 Nov	Yang XY	-
17449901	Association of the ARLTS1 Cys148Arg variant with sporadic and familial colorectal cancer.	Carcinogenesis	2007 Aug	Castellvi-Bel S	-
17699778	Tumor suppressor functions of ARLTS1 in lung cancers.	Cancer Res	2007 Aug 15	Yendamuri S	-
19509554	Association of the ARLTS1 variants with familial ovarian cancer risk in China.	Int J Gynecol Cancer	2009 May	Yang XY	doi: 10.1111/IGC.0b013e3181a39d03.
23940804	ARLTS1 and prostate cancer risk--analysis of expression and regulation.	PLoS One	2013 Aug 5	Siltanen S	doi: 10.1371/journal.pone.0072040

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr13	49631721	3'UTR	novel		0.37
ACC	chr13	49630934	Missense_Mutation	novel	P163A	0.4
ACC	chr13	49630588	Silent	rs751269133	N47N	0.85
BLCA	chr13	49630756	Silent	novel	L103L	0.16
BLCA	chr13	49630487	Nonsense_Mutation	novel	Q14*	0.22	MMR_HSR1
BRCA	chr13	49630786	Silent	novel	A113A	0.14
BRCA	chr13	49630515	Missense_Mutation	rs769707452	A23V	0.98	MMR_HSR1
BRCA	chr13	49630673	Missense_Mutation	NA	D76N	0.59	MMR_HSR1
CESC	chr13	49630531	Silent	NA	L28L	0.23
CESC	chr13	49631869	3'UTR	novel		0.43
CESC	chr13	49632397	3'UTR	novel		0.78
CESC	chr13	49632133	3'UTR	novel		0.34
CESC	chr13	49632519	3'UTR	novel		0.13
CESC	chr13	49630459	Silent	novel	V4V	0.19
CESC	chr13	49631508	3'UTR	novel		0.48
CESC	chr13	49631610	3'UTR	novel		0.44
COAD	chr13	49632609	3'UTR	novel		0.15
COAD	chr13	49631510	3'UTR	novel		0.34
COAD	chr13	49632688	3'UTR	novel		0.33
COAD	chr13	49630639	Frame_Shift_Ins	NA	*Q67Afs27**	0.38	MMR_HSR1
COAD	chr13	49632148	3'UTR	novel		0.35
COAD	chr13	49631244	3'UTR	novel		0.39
COAD	chr13	49632758	3'UTR	novel		0.25
COAD	chr13	49631485	3'UTR	novel		0.34
COAD	chr13	49632500	3'UTR	novel		0.27
COAD	chr13	49632239	3'UTR	rs540838776		0.31
COAD	chr13	49630637	Missense_Mutation	rs143660006	V64I	0.25	MMR_HSR1
COAD	chr13	49630790	Missense_Mutation	NA	V115I	0.27	MMR_HSR1
COAD	chr13	49630527	Missense_Mutation	NA	T27M	0.34	MMR_HSR1
COAD	chr13	49630700	Missense_Mutation	rs374531869	V85M	0.1	MMR_HSR1
COAD	chr13	49631423	3'UTR	rs537844515		0.35
COAD	chr13	49630640	Frame_Shift_Del	NA	*Q67Rfs41**	0.24	MMR_HSR1
COAD	chr13	49631426	3'UTR	rs776460007		0.2
COAD	chr13	49630645	Silent	NA	G66G	0.43
COAD	chr13	49633258	3'UTR	novel		0.3
COAD	chr13	49632484	3'UTR	novel		0.1
COAD	chr13	49632147	3'UTR	novel		0.27
COAD	chr13	49632267	3'UTR	novel		0.11
COAD	chr13	49630648	Missense_Mutation	NA	Q67H	0.15	MMR_HSR1
COAD	chr13	49631423	3'UTR	rs537844515		0.23
COAD	chr13	49632996	3'UTR	novel		0.61
COAD	chr13	49630663	Silent	NA	A72A	0.47
COAD	chr13	49632284	3'UTR	novel		0.18
COAD	chr13	49633373	3'UTR	novel		0.19
COAD	chr13	49633536	3'UTR	novel		0.1
COAD	chr13	49631423	3'UTR	rs537844515		0.17
COAD	chr13	49631426	3'UTR	rs776460007		0.15
COAD	chr13	49632032	3'UTR	novel		0.4
COAD	chr13	49630527	Missense_Mutation	NA	T27M	0.49	MMR_HSR1
COAD	chr13	49632284	3'UTR	novel		0.05
COAD	chr13	49632466	3'UTR	rs564833100		0.17
COAD	chr13	49632073	3'UTR	novel		0.2
ESCA	chr13	49632141	3'UTR	novel		0.28
ESCA	chr13	49632239	3'UTR	rs540838776		0.37
ESCA	chr13	49633395	3'UTR	novel		0.38
GBM	chr13	49630813	Missense_Mutation	novel	N122K	0.32	MMR_HSR1
GBM	chr13	49630689	Missense_Mutation	novel	T81K	0.08	MMR_HSR1
GBM	chr13	49630639	Frame_Shift_Ins	NA	*Q67Afs27**	0.08	MMR_HSR1
GBM	chr13	49630816	Silent	NA	K123K	0.38
HNSC	chr13	49630466	Missense_Mutation	novel	R7G	0.11
KIRC	chr13	49630705	Silent	rs377295532	Y86Y	0.25
LAML	chr13	49630772	Missense_Mutation	rs753334860	D109N	0.12	MMR_HSR1
LGG	chr13	49630615	Silent	rs369494120	H56H	0.32
LIHC	chr13	49633543	3'UTR	novel		0.44
LIHC	chr13	49632926	3'UTR	novel		0.21
LUAD	chr13	49630699	Silent	NA	L84L	0.35
LUAD	chr13	49630487	Missense_Mutation	NA	Q14K	0.47	MMR_HSR1
LUAD	chr13	49630624	Silent	NA	L59L	0.18
LUSC	chr13	49631058	3'UTR	novel		0.3
OV	chr13	49630493	Missense_Mutation	NA	V16L	0.19	MMR_HSR1
OV	chr13	49633562	3'UTR	novel		0.29
OV	chr13	49630639	Frame_Shift_Ins	NA	*Q67Afs27**	0.08	MMR_HSR1
OV	chr13	49630639	Frame_Shift_Ins	NA	*Q67Afs27**	0.13	MMR_HSR1
OV	chr13	49630535	Missense_Mutation	novel	Y30H	0.04	MMR_HSR1
PRAD	chr13	49630528	Silent	rs557546186	T27T	0.49
READ	chr13	49632669	3'UTR	novel		0.29
READ	chr13	49630479	Missense_Mutation	rs566163670	A11V	0.52
READ	chr13	49633484	3'UTR	novel		0.14
READ	chr13	49632825	3'UTR	novel		0.12
READ	chr13	49631058	3'UTR	novel		0.11
READ	chr13	49631441	3'UTR	novel		0.39
SARC	chr13	49633478	3'UTR	novel		0.08
SKCM	chr13	49630547	Missense_Mutation	rs776703350	G34S	0.37	MMR_HSR1
SKCM	chr13	49630429	Splice_Site	NA		0.17
SKCM	chr13	49630737	Missense_Mutation	NA	P97L	0.2	MMR_HSR1
SKCM	chr13	49630634	Missense_Mutation	NA	D63N	0.13	MMR_HSR1
SKCM	chr13	49630546	Silent	novel	K33K	0.06
SKCM	chr13	49630772	Missense_Mutation	rs753334860	D109N	0.14	MMR_HSR1
SKCM	chr13	49630772	Missense_Mutation	rs753334860	D109N	0.42	MMR_HSR1
SKCM	chr13	49630459	Silent	novel	V4V	0.41
SKCM	chr13	49630696	Silent	NA	I83I	0.35
SKCM	chr13	49630634	Missense_Mutation	NA	D63N	0.43	MMR_HSR1
STAD	chr13	49630835	Missense_Mutation	NA	L130V	0.74
STAD	chr13	49630790	Missense_Mutation	NA	V115I	0.42	MMR_HSR1
UCEC	chr13	49632098	3'UTR	novel		0.12
UCEC	chr13	49632674	3'UTR	novel		0.37
UCEC	chr13	49632881	3'UTR	novel		0.42
UCEC	chr13	49631837	3'UTR	novel		0.6
UCEC	chr13	49633406	3'UTR	novel		0.29
UCEC	chr13	49631147	3'UTR	novel		0.28
UCEC	chr13	49633581	3'UTR	novel		0.45
UCEC	chr13	49633173	3'UTR	novel		0.32
UCEC	chr13	49630901	Missense_Mutation	rs778849305	R152W	0.18
UCEC	chr13	49632284	3'UTR	novel		0.29
UCEC	chr13	49633050	3'UTR	novel		0.29
UCEC	chr13	49630479	Missense_Mutation	rs566163670	A11V	0.33
UCEC	chr13	49632865	3'UTR	novel		0.09
UCEC	chr13	49633568	3'UTR	novel		0.51
UCEC	chr13	49632239	3'UTR	rs540838776		0.33
UCEC	chr13	49633327	3'UTR	novel		0.35
UCEC	chr13	49632181	3'UTR	novel		0.55
UCEC	chr13	49632103	3'UTR	novel		0.34
UCEC	chr13	49630528	Silent	rs557546186	T27T	0.53
UCEC	chr13	49630548	Missense_Mutation	novel	G34D	0.53	MMR_HSR1
UCEC	chr13	49630721	Missense_Mutation	novel	D92Y	0.5	MMR_HSR1
UCEC	chr13	49631031	Missense_Mutation	novel	R195I	0.53
UCEC	chr13	49632912	3'UTR	novel		0.22
UCEC	chr13	49632238	3'UTR	rs200803938		0.5
UCEC	chr13	49631546	3'UTR	novel		0.42
UCEC	chr13	49632300	3'UTR	novel		0.52
UCEC	chr13	49632646	3'UTR	novel		0.33
UCEC	chr13	49631596	3'UTR	novel		0.44
UCEC	chr13	49630990	Silent	novel	L181L	0.4
UCEC	chr13	49631058	3'UTR	novel		0.15
UCEC	chr13	49631690	3'UTR	novel		0.3
UCEC	chr13	49632222	3'UTR	novel		0.16
UCEC	chr13	49632663	3'UTR	novel		0.16
UCEC	chr13	49633288	3'UTR	novel		0.36
UCEC	chr13	49633499	3'UTR	novel		0.31
UCEC	chr13	49632251	3'UTR	novel		0.42
UCEC	chr13	49632500	3'UTR	novel		0.32
UCEC	chr13	49630823	Missense_Mutation	novel	A126S	0.33
UCEC	chr13	49630969	Missense_Mutation	novel	K174N	0.29
UCEC	chr13	49630534	Silent	novel	L29L	0.4
UCEC	chr13	49630779	Missense_Mutation	novel	N111S	0.24	MMR_HSR1
UCEC	chr13	49630977	Missense_Mutation	novel	S177I	0.26
UCEC	chr13	49632344	3'UTR	novel		0.23
UCEC	chr13	49631282	3'UTR	novel		0.38
UCEC	chr13	49633023	3'UTR	novel		0.33
UCEC	chr13	49630732	Silent	novel	R95R	0.25
UCEC	chr13	49630628	Missense_Mutation	NA	L61I	0.29	MMR_HSR1
UCEC	chr13	49631097	3'UTR	novel		0.22
UCEC	chr13	49633121	3'UTR	novel		0.37
UCEC	chr13	49633278	3'UTR	novel		0.33
UCEC	chr13	49631098	3'UTR	novel		0.4
UCEC	chr13	49631494	3'UTR	novel		0.44
UCEC	chr13	49632104	3'UTR	novel		0.54
UCEC	chr13	49633242	3'UTR	novel		0.44
UCS	chr13	49630580	Missense_Mutation	novel	G45C	0.32	MMR_HSR1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.339	2.1677e-19
COAD	DEL	0.0266	0.24773
KIRC	DEL	0.1174	0.031318
LGG	DEL	0.2105	5.4722e-09
MESO	DEL	0.4023	0.0010209
THCA	DEL	0.0341	0.011063

Survival Analysis

Cancer	P-value	Q-value
THYM	0.026	Kaplan-Meier Survival Analysis
STAD	0.011	Kaplan-Meier Survival Analysis
SARC	0.025	Kaplan-Meier Survival Analysis
ACC	0.035	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.024	Kaplan-Meier Survival Analysis
TGCT	0.045	Kaplan-Meier Survival Analysis
BLCA	0.018	Kaplan-Meier Survival Analysis
LAML	0.037	Kaplan-Meier Survival Analysis
LGG	0.00014	Kaplan-Meier Survival Analysis
UVM	0.0014	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152213 (Gene tree)
Gene ID: 115761
Gene Symbol: ARL11
Alias: ARLTS1|FLJ33930
Full Name: ADP ribosylation factor like GTPase 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 5,574 bases
Position: chr13:49,628,299-49,633,872
Accession: 24046
RBP type: canonical RBP
Summary: This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000282026	MMR_HSR1	PF01926.23	0.00013	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000282026	ARL11-201	3760	XM_005266253	ENSP00000282026	196 (aa)	XP_005266310	Q969Q4
ENST00000490932	ARL11-202	217	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000152213's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152213's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152213	ARL11	96	85.185	ENSAMEG00000002767	ARL11	100	85.185	Ailuropoda_melanoleuca
ENSG00000152213	ARL11	100	89.796	ENSCJAG00000022614	ARL11	100	89.796	Callithrix_jacchus
ENSG00000152213	ARL11	97	74.211	ENSCAPG00000006154	ARL11	96	74.211	Cavia_aperea
ENSG00000152213	ARL11	97	74.211	ENSCPOG00000040608	ARL11	96	74.211	Cavia_porcellus
ENSG00000152213	ARL11	100	95.408	ENSCATG00000011750	ARL11	100	95.408	Cercocebus_atys
ENSG00000152213	ARL11	95	77.419	ENSCLAG00000005195	ARL11	94	77.419	Chinchilla_lanigera
ENSG00000152213	ARL11	100	94.898	ENSCSAG00000018612	ARL11	100	94.898	Chlorocebus_sabaeus
ENSG00000152213	ARL11	92	61.290	ENSCPBG00000008579	ARL11	93	61.290	Chrysemys_picta_bellii
ENSG00000152213	ARL11	100	95.408	ENSCANG00000018107	ARL11	100	95.408	Colobus_angolensis_palliatus
ENSG00000152213	ARL11	91	85.393	ENSCGRG00001010023	Arl11	100	85.393	Cricetulus_griseus_chok1gshd
ENSG00000152213	ARL11	91	85.393	ENSCGRG00000006897	Arl11	100	85.393	Cricetulus_griseus_crigri
ENSG00000152213	ARL11	100	80.203	ENSDNOG00000009737	ARL11	100	80.203	Dasypus_novemcinctus
ENSG00000152213	ARL11	90	86.364	ENSDORG00000023352	Arl11	95	86.364	Dipodomys_ordii
ENSG00000152213	ARL11	90	88.636	ENSEASG00005017293	ARL11	97	88.636	Equus_asinus_asinus
ENSG00000152213	ARL11	90	88.636	ENSECAG00000004611	ARL11	97	88.636	Equus_caballus
ENSG00000152213	ARL11	89	83.429	ENSEEUG00000009809	ARL11	92	83.429	Erinaceus_europaeus
ENSG00000152213	ARL11	89	83.429	ENSFDAG00000000040	ARL11	99	83.429	Fukomys_damarensis
ENSG00000152213	ARL11	91	62.162	ENSGAGG00000019477	ARL11	97	62.162	Gopherus_agassizii
ENSG00000152213	ARL11	100	98.980	ENSGGOG00000004442	ARL11	100	98.980	Gorilla_gorilla
ENSG00000152213	ARL11	92	79.558	ENSHGLG00000006725	ARL11	99	79.558	Heterocephalus_glaber_female
ENSG00000152213	ARL11	92	79.558	ENSHGLG00100009774	ARL11	99	79.558	Heterocephalus_glaber_male
ENSG00000152213	ARL11	90	81.356	ENSJJAG00000001803	Arl11	95	81.356	Jaculus_jaculus
ENSG00000152213	ARL11	86	54.706	ENSLACG00000011405	ARL11	89	54.706	Latimeria_chalumnae
ENSG00000152213	ARL11	90	86.364	ENSLAFG00000001838	ARL11	100	86.364	Loxodonta_africana
ENSG00000152213	ARL11	100	94.388	ENSMMUG00000011766	ARL11	100	94.388	Macaca_mulatta
ENSG00000152213	ARL11	100	95.408	ENSMLEG00000013105	ARL11	100	95.408	Mandrillus_leucophaeus
ENSG00000152213	ARL11	91	80.337	ENSMICG00000006637	ARL11	97	80.337	Microcebus_murinus
ENSG00000152213	ARL11	89	85.143	ENSMOCG00000006454	Arl11	99	85.143	Microtus_ochrogaster
ENSG00000152213	ARL11	98	66.495	ENSMODG00000024105	ARL11	100	66.495	Monodelphis_domestica
ENSG00000152213	ARL11	90	86.932	MGP_CAROLIEiJ_G0019382	Arl11	100	86.932	Mus_caroli
ENSG00000152213	ARL11	90	86.364	ENSMUSG00000043157	Arl11	100	86.364	Mus_musculus
ENSG00000152213	ARL11	90	85.227	MGP_PahariEiJ_G0030400	Arl11	100	85.227	Mus_pahari
ENSG00000152213	ARL11	90	84.659	MGP_SPRETEiJ_G0020274	Arl11	100	84.659	Mus_spretus
ENSG00000152213	ARL11	92	83.978	ENSMPUG00000018376	ARL11	96	83.978	Mustela_putorius_furo
ENSG00000152213	ARL11	90	83.616	ENSMLUG00000029560	ARL11	97	83.616	Myotis_lucifugus
ENSG00000152213	ARL11	90	88.068	ENSNGAG00000004637	Arl11	100	88.068	Nannospalax_galili
ENSG00000152213	ARL11	100	98.980	ENSNLEG00000031734	ARL11	100	98.980	Nomascus_leucogenys
ENSG00000152213	ARL11	90	69.663	ENSOANG00000015544	ARL11	97	69.663	Ornithorhynchus_anatinus
ENSG00000152213	ARL11	90	83.523	ENSOCUG00000003013	ARL11	98	83.523	Oryctolagus_cuniculus
ENSG00000152213	ARL11	90	84.181	ENSOGAG00000005346	ARL11	100	84.181	Otolemur_garnettii
ENSG00000152213	ARL11	90	79.096	ENSOARG00000005963	ARL11	98	79.096	Ovis_aries
ENSG00000152213	ARL11	100	98.980	ENSPPAG00000033238	ARL11	100	98.980	Pan_paniscus
ENSG00000152213	ARL11	100	98.980	ENSPTRG00000005876	ARL11	100	98.980	Pan_troglodytes
ENSG00000152213	ARL11	100	95.408	ENSPANG00000006280	ARL11	100	95.408	Papio_anubis
ENSG00000152213	ARL11	92	60.000	ENSPSIG00000001265	ARL11	100	60.000	Pelodiscus_sinensis
ENSG00000152213	ARL11	86	69.412	ENSPCIG00000002831	ARL11	95	69.412	Phascolarctos_cinereus
ENSG00000152213	ARL11	89	84.000	ENSRNOG00000014653	Arl11	100	84.000	Rattus_norvegicus
ENSG00000152213	ARL11	100	95.408	ENSRBIG00000024949	ARL11	100	95.408	Rhinopithecus_bieti
ENSG00000152213	ARL11	100	95.408	ENSRROG00000000591	ARL11	100	95.408	Rhinopithecus_roxellana
ENSG00000152213	ARL11	98	64.433	ENSSHAG00000004853	ARL11	100	64.433	Sarcophilus_harrisii
ENSG00000152213	ARL11	92	56.216	ENSSPUG00000006852	ARL11	98	56.216	Sphenodon_punctatus
ENSG00000152213	ARL11	91	79.444	ENSSSCG00000036810	ARL11	91	79.444	Sus_scrofa
ENSG00000152213	ARL11	92	85.635	ENSUAMG00000009531	ARL11	99	85.635	Ursus_americanus
ENSG00000152213	ARL11	92	85.635	ENSUMAG00000018435	ARL11	99	85.635	Ursus_maritimus
ENSG00000152213	ARL11	89	58.286	ENSXETG00000015673	arl11	99	58.286	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002244	hematopoietic progenitor cell differentiation	-	IEA	Process
GO:0005515	protein binding	16189514.19060904.	IPI	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0016192	vesicle-mediated transport	21873635.	IBA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.