EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29207195A novel correlation between ATP5A1 gene expression and progression of human clear cell renal cell carcinoma identified by coexpression analysis.Oncol Rep2018 FebYuan Ldoi: 10.3892/or.2017.6132
28687786Involvement of FANCD2 in Energy Metabolism via ATP5α.Sci Rep2017 Jul 7Jayabal Pdoi: 10.1038/s41598-017-05150-1.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1846084363Splice_RegionnovelR527R0.22
BLCAchr1846091744Missense_MutationnovelR83C0.36
BLCAchr1846084538Missense_MutationnovelV516L0.1
BLCAchr1846087145Missense_MutationnovelR347W0.3
BLCAchr1846084303Missense_MutationnovelF547L0.54
BLCAchr1846089876Missense_MutationNAE144K0.18
BLCAchr1846084286Missense_MutationnovelA553G0.53
BRCAchr1846087074SilentNAI370I0.29
BRCAchr1846084305Missense_MutationNAF547V0.14
BRCAchr1846088196Missense_MutationNAE238Q0.24
BRCAchr1846087406Missense_MutationNAM296V0.32
BRCAchr1846095043IntronNA0.36
CESCchr1846087464Silentrs758599519S276S0.31
CESCchr1846084544Missense_MutationnovelH514Y0.64
COADchr1846091758Missense_MutationNAG78D0.41
COADchr1846088251SilentNAT219T0.13
COADchr1846086458Missense_Mutationrs201477144R405C0.3
COADchr1846095046Splice_Regionnovel0.07
COADchr1846087185SilentnovelG333G0.14
COADchr1846091773Missense_MutationNAR73H0.32
COADchr1846087219Missense_Mutationrs773771619R322H0.33
COADchr1846091843Missense_MutationNAE50Q0.35
COADchr1846095075SilentNAS39S0.19
ESCAchr1846095068Missense_MutationnovelH42N0.2
GBMchr1846088155SilentNAQ251Q0.42
GBMchr1846086444SilentnovelN409N0.1
GBMchr1846091709Missense_MutationnovelE94D0.13
HNSCchr1846084506Missense_MutationnovelI526M0.23
HNSCchr1846086195Silentrs141613719F449F0.54
KIRCchr18460841623'UTRnovel0.4
KIRCchr1846089514Intronnovel0.23
KIRCchr1846086182Missense_MutationNAD454N0.3
KIRPchr1846091731Missense_MutationNAL87P0.25
KIRPchr1846086149Missense_Mutationrs771547673V465M0.12
LAMLchr1846089845Missense_MutationnovelL154P0.13
LGGchr1846087365SilentnovelI309I0.46
LGGchr1846088167SilentnovelV247V0.4
LIHCchr1846091860Intronnovel0.15
LIHCchr1846091914Intronnovel0.45
LIHCchr1846089523Intronnovel0.78
LIHCchr18460842783'UTRnovel0.32
LIHCchr1846087492Missense_MutationNAD267V0.24
LUADchr1846084336SilentNAS536S0.21
LUADchr1846091743Missense_Mutationrs146467617R83H0.16
LUADchr1846088128In_Frame_DelnovelV260del0.32
LUADchr18460842423'UTRnovel0.28
LUADchr1846091976Intronnovel0.88
LUADchr1846086492Splice_RegionnovelI393I0.25
LUADchr1846089581Missense_MutationNAG212A0.13
LUADchr1846091737Missense_MutationNAH85L0.05
LUSCchr1846095002Intronnovel0.18
LUSCchr1846084528Missense_MutationNAH519L0.12
LUSCchr1846088232Missense_Mutationrs367927966I226V0.25
LUSCchr1846084580Missense_MutationnovelS502G0.16
LUSCchr1846087040Missense_MutationNAP382A0.06
LUSCchr1846095132Splice_SitenovelX21_splice0.22
MESOchr1846091799SilentnovelT64T0.28
OVchr1846087109Missense_MutationnovelF359I0.1
OVchr1846089991Missense_MutationNAM105I0.24
OVchr1846089571Missense_MutationnovelQ215H0.05
PAADchr1846089705Nonsense_MutationnovelR171*0.18
PAADchr1846087436Frame_Shift_DelnovelQ286Sfs*230.32
PRADchr1846088170Nonsense_MutationnovelY246*0.15
PRADchr1846086466Missense_Mutationrs776829339K402R0.38
READchr1846095025Intronrs3697134790.15
READchr1846087375Missense_MutationnovelH306R0.42
READchr1846089671Missense_MutationNAR182Q0.4
READchr1846091737Missense_MutationNAH85R0.45
SARCchr1846098304Intronnovel0.71
SARCchr1846089861Missense_MutationnovelR149C0.07
SKCMchr18460841903'UTRnovel0.33
SKCMchr1846098188Missense_MutationNAP15L0.22
SKCMchr1846088137SilentnovelA257A0.46
SKCMchr1846086471Missense_MutationnovelF400L0.19
SKCMchr1846087407SilentNAS295S0.62
SKCMchr18460841733'UTRnovel0.28
SKCMchr1846095104Missense_MutationnovelF30V0.22
STADchr1846091818Missense_Mutationrs150488495R58H0.15
STADchr1846095025Intronrs3697134790.28
STADchr1846087373Missense_MutationNAA307P0.2
STADchr1846084601Missense_MutationNAY495H0.13
STADchr1846091877Intronnovel0.2
STADchr1846087231Missense_MutationnovelA318V0.22
STADchr1846086150Silentrs143320751G464G0.24
UCECchr1846089883SilentNAP141P0.3
UCECchr18460842463'UTRnovel0.08
UCECchr1846086457Missense_Mutationrs375873918R405H0.43
UCECchr1846084312SilentnovelV544V0.3
UCECchr18460841583'UTRnovel0.23
UCECchr1846084551Missense_MutationNAF511L0.26
UCECchr1846089710Missense_Mutationrs765711330R169H0.46
UCECchr1846089560Splice_Regionnovel0.16
UCECchr1846089713Missense_Mutationrs144159915T168M0.38
UCECchr1846087171Missense_MutationnovelP338H0.22
UCECchr1846091818Missense_Mutationrs150488495R58H0.16
UCECchr1846089504Intronnovel0.47
UCECchr1846086413Missense_MutationnovelA420T0.3
UCECchr1846087231Missense_MutationNAA318D0.41
UCECchr1846089889Silentrs371042141D139D0.27
UCECchr1846084538Missense_MutationnovelV516L0.43
UCECchr1846091898Intronnovel0.44
UCECchr1846087356Silentrs771300607D312D0.29
UCECchr1846089510Intronnovel0.33
UCECchr1846089661SilentnovelV185V0.41
UCECchr1846095029Intronrs7664910970.32
UCECchr18460842653'UTRrs3719177540.4
UCECchr1846087197SilentNAR329R0.51
UCECchr1846087014Silentrs765799829D390D0.39
UCECchr1846087355Missense_Mutationrs747589493D313N0.5
UCECchr1846091742SilentnovelR83R0.45
UCECchr1846087362SilentnovelI310I0.18
UCECchr1846089895SilentnovelI137I0.31
UCECchr1846087353Silentrs773540706D313D0.26
UCECchr1846089576Nonsense_MutationnovelR214*0.32
UCECchr1846086477SilentnovelE398E0.35
UCECchr1846086150Silentrs143320751G464G0.3
UCECchr1846094994Intronnovel0.26
UCECchr1846089906Missense_MutationNAT134A0.38
UCECchr1846091696Missense_Mutationrs745896289S99P0.41
UCECchr1846095055Missense_MutationNAT46N0.43
UCECchr1846086194Missense_MutationNAG450S0.41
UCECchr1846087198Missense_MutationnovelR329H0.23
UCECchr1846091743Missense_Mutationrs146467617R83H0.21
UCECchr1846091888Intronnovel0.18
UCECchr1846095032Intronnovel0.2
UCECchr1846095042Intronnovel0.35
UCECchr1846091797Missense_MutationNAS65F0.07
UCECchr18460841423'Flanknovel0.4
UCECchr1846095073Missense_MutationnovelN40S0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LIHCDEL0.22160.019373
UCECDEL0.12240.006131

Survival Analysis
CancerP-value Q-value
THYM0.031

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.019

Kaplan-Meier Survival Analysis

MESO0.0075

Kaplan-Meier Survival Analysis

SKCM0.0082

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

COAD0.028

Kaplan-Meier Survival Analysis

PAAD0.01

Kaplan-Meier Survival Analysis

LAML0.013

Kaplan-Meier Survival Analysis

LIHC0.032

Kaplan-Meier Survival Analysis

DLBC0.0038

Kaplan-Meier Survival Analysis

LGG0.0019

Kaplan-Meier Survival Analysis

UVM0.018

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000152234 (Gene tree)
Gene ID
498
Gene Symbol
ATP5F1A
Alias
ATP5A|hATP1|OMR|ORM|ATP5AL2|ATPM|ATP5A1
Full Name
ATP synthase F1 subunit alpha
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
24,087 bases
Position
chr18:46,080,248-46,104,334
Accession
823
RBP type
non-canonical RBP
Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000590324ATP5F1A-212807-ENSP00000465259144 (aa)-K7EJP1
ENST00000591981ATP5F1A-217565-ENSP0000046580544 (aa)-K7EKV9
ENST00000282050ATP5F1A-2011945XM_017025789ENSP00000282050553 (aa)XP_016881278P25705
ENST00000590156ATP5F1A-2111931-ENSP0000046630958 (aa)-K7EM08
ENST00000591267ATP5F1A-216460--- (aa)--
ENST00000593152ATP5F1A-2202258-ENSP00000465477503 (aa)-P25705
ENST00000398752ATP5F1A-2025818-ENSP00000381736553 (aa)-P25705
ENST00000586523ATP5F1A-2044547--- (aa)--
ENST00000592989ATP5F1A-219553-ENSP00000467830111 (aa)-K7EQH4
ENST00000590665ATP5F1A-2151793-ENSP00000467037531 (aa)-P25705
ENST00000590448ATP5F1A-214604--- (aa)--
ENST00000587902ATP5F1A-206571--- (aa)--
ENST00000589611ATP5F1A-209995--- (aa)--
ENST00000592364ATP5F1A-218576-ENSP0000046861877 (aa)-K7ESA0
ENST00000589869ATP5F1A-210910-ENSP00000465497207 (aa)-K7EK77
ENST00000585650ATP5F1A-203520-ENSP0000046798378 (aa)-K7EQU6
ENST00000586592ATP5F1A-2052214-ENSP0000046627590 (aa)-A0A0A0MTS3
ENST00000590406ATP5F1A-213756-ENSP00000468458205 (aa)-K7ERX7
ENST00000588390ATP5F1A-207556--- (aa)--
ENST00000589252ATP5F1A-208662-ENSP00000466975199 (aa)-K7ENJ4
Gene Model
Click here to download ENSG00000152234's gene model file
Pathways
Pathway IDPathway NameSource
hsa00190Oxidative phosphorylationKEGG
hsa01100Metabolic pathwaysKEGG
hsa04714ThermogenesisKEGG
hsa05010Alzheimer diseaseKEGG
hsa05012Parkinson diseaseKEGG
hsa05016Huntington diseaseKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000152234Body Height6.1560000E-005-
ENSG00000152234Body Height7.4140000E-005-
ENSG00000152234Body Height5.8140000E-005-
ENSG00000152234Body Height6.1530000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000152234rs124573421846085594?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152234's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000152234ATP5F1A10087.387FBgn0011211blw9782.407Drosophila_melanogaster
ENSG00000152234ATP5F1A10099.346ENSMUSG00000025428Atp5a19998.606Mus_musculus
ENSG00000152234ATP5F1A10074.396YBL099W9373.767Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000275mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)21873635.IBAComponent
GO:0001937negative regulation of endothelial cell proliferation10077593.IMPProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding10077593.11410595.11741979.15161933.19285951.19343720.19688755.20618440.21106936.22309213.30021884.IPIFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005524ATP binding-ISSFunction
GO:0005739mitochondrion20833797.HDAComponent
GO:0005739mitochondrion1830491.NASComponent
GO:0005743mitochondrial inner membrane19016746.IDAComponent
GO:0005753mitochondrial proton-transporting ATP synthase complex12110673.IDAComponent
GO:0005759mitochondrial matrix-TASComponent
GO:0005886plasma membrane10077593.IDAComponent
GO:0006629lipid metabolic process-ISSProcess
GO:0006754ATP biosynthetic process21873635.IBAProcess
GO:0006754ATP biosynthetic process12110673.ICProcess
GO:0006754ATP biosynthetic process21106936.IMPProcess
GO:0006754ATP biosynthetic process1830491.NASProcess
GO:0006754ATP biosynthetic process-TASProcess
GO:0006979response to oxidative stress21873635.IBAProcess
GO:0008180COP9 signalosome18850735.IDAComponent
GO:0015986ATP synthesis coupled proton transport21873635.IBAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016020membrane21106936.IDAComponent
GO:0016887ATPase activity21873635.IBAFunction
GO:0016887ATPase activity12110673.IDAFunction
GO:0022857transmembrane transporter activity12110673.ICFunction
GO:0022900electron transport chain21873635.IBAProcess
GO:0042288MHC class I protein binding17643490.IDAFunction
GO:0042407cristae formation-TASProcess
GO:0042776mitochondrial ATP synthesis coupled proton transport12110673.ICProcess
GO:0042776mitochondrial ATP synthesis coupled proton transport-TASProcess
GO:0043531ADP binding21873635.IBAFunction
GO:0043532angiostatin binding21106936.IPIFunction
GO:0043536positive regulation of blood vessel endothelial cell migration21106936.IGIProcess
GO:0045259proton-transporting ATP synthase complex21106936.IDAComponent
GO:0046034ATP metabolic process21873635.IBAProcess
GO:0046933proton-transporting ATP synthase activity, rotational mechanism21873635.IBAFunction
GO:0046933proton-transporting ATP synthase activity, rotational mechanism21106936.IMPFunction
GO:0046933proton-transporting ATP synthase activity, rotational mechanism-ISSFunction
GO:0070062extracellular exosome19056867.23533145.HDAComponent
GO:0099132ATP hydrolysis coupled cation transmembrane transport-IEAProcess
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