EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29207195	A novel correlation between ATP5A1 gene expression and progression of human clear cell renal cell carcinoma identified by coexpression analysis.	Oncol Rep	2018 Feb	Yuan L	doi: 10.3892/or.2017.6132
28687786	Involvement of FANCD2 in Energy Metabolism via ATP5α.	Sci Rep	2017 Jul 7	Jayabal P	doi: 10.1038/s41598-017-05150-1.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr18	46084363	Splice_Region	novel	R527R	0.22
BLCA	chr18	46091744	Missense_Mutation	novel	R83C	0.36
BLCA	chr18	46084538	Missense_Mutation	novel	V516L	0.1
BLCA	chr18	46087145	Missense_Mutation	novel	R347W	0.3
BLCA	chr18	46084303	Missense_Mutation	novel	F547L	0.54
BLCA	chr18	46089876	Missense_Mutation	NA	E144K	0.18
BLCA	chr18	46084286	Missense_Mutation	novel	A553G	0.53
BRCA	chr18	46087074	Silent	NA	I370I	0.29
BRCA	chr18	46084305	Missense_Mutation	NA	F547V	0.14
BRCA	chr18	46088196	Missense_Mutation	NA	E238Q	0.24
BRCA	chr18	46087406	Missense_Mutation	NA	M296V	0.32
BRCA	chr18	46095043	Intron	NA		0.36
CESC	chr18	46087464	Silent	rs758599519	S276S	0.31
CESC	chr18	46084544	Missense_Mutation	novel	H514Y	0.64
COAD	chr18	46091758	Missense_Mutation	NA	G78D	0.41
COAD	chr18	46088251	Silent	NA	T219T	0.13
COAD	chr18	46086458	Missense_Mutation	rs201477144	R405C	0.3
COAD	chr18	46095046	Splice_Region	novel		0.07
COAD	chr18	46087185	Silent	novel	G333G	0.14
COAD	chr18	46091773	Missense_Mutation	NA	R73H	0.32
COAD	chr18	46087219	Missense_Mutation	rs773771619	R322H	0.33
COAD	chr18	46091843	Missense_Mutation	NA	E50Q	0.35
COAD	chr18	46095075	Silent	NA	S39S	0.19
ESCA	chr18	46095068	Missense_Mutation	novel	H42N	0.2
GBM	chr18	46088155	Silent	NA	Q251Q	0.42
GBM	chr18	46086444	Silent	novel	N409N	0.1
GBM	chr18	46091709	Missense_Mutation	novel	E94D	0.13
HNSC	chr18	46084506	Missense_Mutation	novel	I526M	0.23
HNSC	chr18	46086195	Silent	rs141613719	F449F	0.54
KIRC	chr18	46084162	3'UTR	novel		0.4
KIRC	chr18	46089514	Intron	novel		0.23
KIRC	chr18	46086182	Missense_Mutation	NA	D454N	0.3
KIRP	chr18	46091731	Missense_Mutation	NA	L87P	0.25
KIRP	chr18	46086149	Missense_Mutation	rs771547673	V465M	0.12
LAML	chr18	46089845	Missense_Mutation	novel	L154P	0.13
LGG	chr18	46087365	Silent	novel	I309I	0.46
LGG	chr18	46088167	Silent	novel	V247V	0.4
LIHC	chr18	46091860	Intron	novel		0.15
LIHC	chr18	46091914	Intron	novel		0.45
LIHC	chr18	46089523	Intron	novel		0.78
LIHC	chr18	46084278	3'UTR	novel		0.32
LIHC	chr18	46087492	Missense_Mutation	NA	D267V	0.24
LUAD	chr18	46084336	Silent	NA	S536S	0.21
LUAD	chr18	46091743	Missense_Mutation	rs146467617	R83H	0.16
LUAD	chr18	46088128	In_Frame_Del	novel	V260del	0.32
LUAD	chr18	46084242	3'UTR	novel		0.28
LUAD	chr18	46091976	Intron	novel		0.88
LUAD	chr18	46086492	Splice_Region	novel	I393I	0.25
LUAD	chr18	46089581	Missense_Mutation	NA	G212A	0.13
LUAD	chr18	46091737	Missense_Mutation	NA	H85L	0.05
LUSC	chr18	46095002	Intron	novel		0.18
LUSC	chr18	46084528	Missense_Mutation	NA	H519L	0.12
LUSC	chr18	46088232	Missense_Mutation	rs367927966	I226V	0.25
LUSC	chr18	46084580	Missense_Mutation	novel	S502G	0.16
LUSC	chr18	46087040	Missense_Mutation	NA	P382A	0.06
LUSC	chr18	46095132	Splice_Site	novel	X21_splice	0.22
MESO	chr18	46091799	Silent	novel	T64T	0.28
OV	chr18	46087109	Missense_Mutation	novel	F359I	0.1
OV	chr18	46089991	Missense_Mutation	NA	M105I	0.24
OV	chr18	46089571	Missense_Mutation	novel	Q215H	0.05
PAAD	chr18	46089705	Nonsense_Mutation	novel	R171*	0.18
PAAD	chr18	46087436	Frame_Shift_Del	novel	*Q286Sfs23**	0.32
PRAD	chr18	46088170	Nonsense_Mutation	novel	Y246*	0.15
PRAD	chr18	46086466	Missense_Mutation	rs776829339	K402R	0.38
READ	chr18	46095025	Intron	rs369713479		0.15
READ	chr18	46087375	Missense_Mutation	novel	H306R	0.42
READ	chr18	46089671	Missense_Mutation	NA	R182Q	0.4
READ	chr18	46091737	Missense_Mutation	NA	H85R	0.45
SARC	chr18	46098304	Intron	novel		0.71
SARC	chr18	46089861	Missense_Mutation	novel	R149C	0.07
SKCM	chr18	46084190	3'UTR	novel		0.33
SKCM	chr18	46098188	Missense_Mutation	NA	P15L	0.22
SKCM	chr18	46088137	Silent	novel	A257A	0.46
SKCM	chr18	46086471	Missense_Mutation	novel	F400L	0.19
SKCM	chr18	46087407	Silent	NA	S295S	0.62
SKCM	chr18	46084173	3'UTR	novel		0.28
SKCM	chr18	46095104	Missense_Mutation	novel	F30V	0.22
STAD	chr18	46091818	Missense_Mutation	rs150488495	R58H	0.15
STAD	chr18	46095025	Intron	rs369713479		0.28
STAD	chr18	46087373	Missense_Mutation	NA	A307P	0.2
STAD	chr18	46084601	Missense_Mutation	NA	Y495H	0.13
STAD	chr18	46091877	Intron	novel		0.2
STAD	chr18	46087231	Missense_Mutation	novel	A318V	0.22
STAD	chr18	46086150	Silent	rs143320751	G464G	0.24
UCEC	chr18	46089883	Silent	NA	P141P	0.3
UCEC	chr18	46084246	3'UTR	novel		0.08
UCEC	chr18	46086457	Missense_Mutation	rs375873918	R405H	0.43
UCEC	chr18	46084312	Silent	novel	V544V	0.3
UCEC	chr18	46084158	3'UTR	novel		0.23
UCEC	chr18	46084551	Missense_Mutation	NA	F511L	0.26
UCEC	chr18	46089710	Missense_Mutation	rs765711330	R169H	0.46
UCEC	chr18	46089560	Splice_Region	novel		0.16
UCEC	chr18	46089713	Missense_Mutation	rs144159915	T168M	0.38
UCEC	chr18	46087171	Missense_Mutation	novel	P338H	0.22
UCEC	chr18	46091818	Missense_Mutation	rs150488495	R58H	0.16
UCEC	chr18	46089504	Intron	novel		0.47
UCEC	chr18	46086413	Missense_Mutation	novel	A420T	0.3
UCEC	chr18	46087231	Missense_Mutation	NA	A318D	0.41
UCEC	chr18	46089889	Silent	rs371042141	D139D	0.27
UCEC	chr18	46084538	Missense_Mutation	novel	V516L	0.43
UCEC	chr18	46091898	Intron	novel		0.44
UCEC	chr18	46087356	Silent	rs771300607	D312D	0.29
UCEC	chr18	46089510	Intron	novel		0.33
UCEC	chr18	46089661	Silent	novel	V185V	0.41
UCEC	chr18	46095029	Intron	rs766491097		0.32
UCEC	chr18	46084265	3'UTR	rs371917754		0.4
UCEC	chr18	46087197	Silent	NA	R329R	0.51
UCEC	chr18	46087014	Silent	rs765799829	D390D	0.39
UCEC	chr18	46087355	Missense_Mutation	rs747589493	D313N	0.5
UCEC	chr18	46091742	Silent	novel	R83R	0.45
UCEC	chr18	46087362	Silent	novel	I310I	0.18
UCEC	chr18	46089895	Silent	novel	I137I	0.31
UCEC	chr18	46087353	Silent	rs773540706	D313D	0.26
UCEC	chr18	46089576	Nonsense_Mutation	novel	R214*	0.32
UCEC	chr18	46086477	Silent	novel	E398E	0.35
UCEC	chr18	46086150	Silent	rs143320751	G464G	0.3
UCEC	chr18	46094994	Intron	novel		0.26
UCEC	chr18	46089906	Missense_Mutation	NA	T134A	0.38
UCEC	chr18	46091696	Missense_Mutation	rs745896289	S99P	0.41
UCEC	chr18	46095055	Missense_Mutation	NA	T46N	0.43
UCEC	chr18	46086194	Missense_Mutation	NA	G450S	0.41
UCEC	chr18	46087198	Missense_Mutation	novel	R329H	0.23
UCEC	chr18	46091743	Missense_Mutation	rs146467617	R83H	0.21
UCEC	chr18	46091888	Intron	novel		0.18
UCEC	chr18	46095032	Intron	novel		0.2
UCEC	chr18	46095042	Intron	novel		0.35
UCEC	chr18	46091797	Missense_Mutation	NA	S65F	0.07
UCEC	chr18	46084142	3'Flank	novel		0.4
UCEC	chr18	46095073	Missense_Mutation	novel	N40S	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.2216	0.019373
UCEC	DEL	0.1224	0.006131

Survival Analysis

Cancer	P-value	Q-value
THYM	0.031	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.019	Kaplan-Meier Survival Analysis
MESO	0.0075	Kaplan-Meier Survival Analysis
SKCM	0.0082	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
COAD	0.028	Kaplan-Meier Survival Analysis
PAAD	0.01	Kaplan-Meier Survival Analysis
LAML	0.013	Kaplan-Meier Survival Analysis
LIHC	0.032	Kaplan-Meier Survival Analysis
DLBC	0.0038	Kaplan-Meier Survival Analysis
LGG	0.0019	Kaplan-Meier Survival Analysis
UVM	0.018	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152234 (Gene tree)
Gene ID: 498
Gene Symbol: ATP5F1A
Alias: ATP5A|hATP1|OMR|ORM|ATP5AL2|ATPM|ATP5A1
Full Name: ATP synthase F1 subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 24,087 bases
Position: chr18:46,080,248-46,104,334
Accession: 823
RBP type: non-canonical RBP
Summary: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590324	ATP5F1A-212	807	-	ENSP00000465259	144 (aa)	-	K7EJP1
ENST00000591981	ATP5F1A-217	565	-	ENSP00000465805	44 (aa)	-	K7EKV9
ENST00000282050	ATP5F1A-201	1945	XM_017025789	ENSP00000282050	553 (aa)	XP_016881278	P25705
ENST00000590156	ATP5F1A-211	1931	-	ENSP00000466309	58 (aa)	-	K7EM08
ENST00000591267	ATP5F1A-216	460	-	-	- (aa)	-	-
ENST00000593152	ATP5F1A-220	2258	-	ENSP00000465477	503 (aa)	-	P25705
ENST00000398752	ATP5F1A-202	5818	-	ENSP00000381736	553 (aa)	-	P25705
ENST00000586523	ATP5F1A-204	4547	-	-	- (aa)	-	-
ENST00000592989	ATP5F1A-219	553	-	ENSP00000467830	111 (aa)	-	K7EQH4
ENST00000590665	ATP5F1A-215	1793	-	ENSP00000467037	531 (aa)	-	P25705
ENST00000590448	ATP5F1A-214	604	-	-	- (aa)	-	-
ENST00000587902	ATP5F1A-206	571	-	-	- (aa)	-	-
ENST00000589611	ATP5F1A-209	995	-	-	- (aa)	-	-
ENST00000592364	ATP5F1A-218	576	-	ENSP00000468618	77 (aa)	-	K7ESA0
ENST00000589869	ATP5F1A-210	910	-	ENSP00000465497	207 (aa)	-	K7EK77
ENST00000585650	ATP5F1A-203	520	-	ENSP00000467983	78 (aa)	-	K7EQU6
ENST00000586592	ATP5F1A-205	2214	-	ENSP00000466275	90 (aa)	-	A0A0A0MTS3
ENST00000590406	ATP5F1A-213	756	-	ENSP00000468458	205 (aa)	-	K7ERX7
ENST00000588390	ATP5F1A-207	556	-	-	- (aa)	-	-
ENST00000589252	ATP5F1A-208	662	-	ENSP00000466975	199 (aa)	-	K7ENJ4

Gene Model

Click here to download ENSG00000152234's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00190	Oxidative phosphorylation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04714	Thermogenesis	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05012	Parkinson disease	KEGG
hsa05016	Huntington disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000152234	Body Height	6.1560000E-005	-
ENSG00000152234	Body Height	7.4140000E-005	-
ENSG00000152234	Body Height	5.8140000E-005	-
ENSG00000152234	Body Height	6.1530000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000152234	rs12457342	18	46085594	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152234's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152234	ATP5F1A	100	87.387	FBgn0011211	blw	97	82.407	Drosophila_melanogaster
ENSG00000152234	ATP5F1A	100	99.346	ENSMUSG00000025428	Atp5a1	99	98.606	Mus_musculus
ENSG00000152234	ATP5F1A	100	74.396	YBL099W		93	73.767	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	21873635.	IBA	Component
GO:0001937	negative regulation of endothelial cell proliferation	10077593.	IMP	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	10077593.11410595.11741979.15161933.19285951.19343720.19688755.20618440.21106936.22309213.30021884.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	-	ISS	Function
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	1830491.	NAS	Component
GO:0005743	mitochondrial inner membrane	19016746.	IDA	Component
GO:0005753	mitochondrial proton-transporting ATP synthase complex	12110673.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005886	plasma membrane	10077593.	IDA	Component
GO:0006629	lipid metabolic process	-	ISS	Process
GO:0006754	ATP biosynthetic process	21873635.	IBA	Process
GO:0006754	ATP biosynthetic process	12110673.	IC	Process
GO:0006754	ATP biosynthetic process	21106936.	IMP	Process
GO:0006754	ATP biosynthetic process	1830491.	NAS	Process
GO:0006754	ATP biosynthetic process	-	TAS	Process
GO:0006979	response to oxidative stress	21873635.	IBA	Process
GO:0008180	COP9 signalosome	18850735.	IDA	Component
GO:0015986	ATP synthesis coupled proton transport	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	21106936.	IDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0016887	ATPase activity	12110673.	IDA	Function
GO:0022857	transmembrane transporter activity	12110673.	IC	Function
GO:0022900	electron transport chain	21873635.	IBA	Process
GO:0042288	MHC class I protein binding	17643490.	IDA	Function
GO:0042407	cristae formation	-	TAS	Process
GO:0042776	mitochondrial ATP synthesis coupled proton transport	12110673.	IC	Process
GO:0042776	mitochondrial ATP synthesis coupled proton transport	-	TAS	Process
GO:0043531	ADP binding	21873635.	IBA	Function
GO:0043532	angiostatin binding	21106936.	IPI	Function
GO:0043536	positive regulation of blood vessel endothelial cell migration	21106936.	IGI	Process
GO:0045259	proton-transporting ATP synthase complex	21106936.	IDA	Component
GO:0046034	ATP metabolic process	21873635.	IBA	Process
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	21873635.	IBA	Function
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	21106936.	IMP	Function
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	-	ISS	Function
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.