EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27862697	ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma.	Cancer Sci	2017 Jan	Yonemori K	doi: 10.1111/cas.13119.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	43225086	Missense_Mutation	novel	D240H	0.24
BLCA	chr2	43225436	Missense_Mutation	NA	S123L	0.54
BLCA	chr2	43225174	Silent	novel	P210P	0.31
BLCA	chr2	43225317	Missense_Mutation	novel	E163K	0.32
BLCA	chr2	43225458	Nonsense_Mutation	novel	E116*	0.23
BLCA	chr2	43224320	Nonstop_Mutation	novel	495Sext81	0.4
BLCA	chr2	43225414	Frame_Shift_Ins	novel	*S131Qfs343**	0.43
BLCA	chr2	43225059	Missense_Mutation	novel	E249K	0.09
BLCA	chr2	43225029	Missense_Mutation	NA	S259G	0.29
BLCA	chr2	43225149	Missense_Mutation	novel	D219Y	0.4
BLCA	chr2	43225150	Silent	novel	A218A	0.43
BLCA	chr2	43225692	Frame_Shift_Ins	NA	*T38Dfs46**	0.57
BLCA	chr2	43225059	Missense_Mutation	NA	E249Q	0.09
BLCA	chr2	43225109	Missense_Mutation	novel	D232V	0.21
BLCA	chr2	43224685	Silent	novel	I373I	0.8
BLCA	chr2	43225059	Missense_Mutation	novel	E249K	0.09
BLCA	chr2	43225130	Missense_Mutation	novel	P225Q	0.38
BLCA	chr2	43225179	Missense_Mutation	novel	G209R	0.32	zf-CCCH
BRCA	chr2	43226311	Missense_Mutation	NA	S2W	0.27
BRCA	chr2	43223849	3'UTR	novel		0.36
BRCA	chr2	43223851	3'UTR	novel		0.33
BRCA	chr2	43225692	Frame_Shift_Ins	NA	*T38Dfs46**	0.5
BRCA	chr2	43225484	Frame_Shift_Del	rs765083004	*G107Afs80**	0.36
BRCA	chr2	43225731	Missense_Mutation	NA	L25F	0.24
BRCA	chr2	43226295	Silent	NA	S7S	0.33
BRCA	chr2	43225335	Missense_Mutation	NA	E157K	0.31
BRCA	chr2	43225428	Missense_Mutation	NA	E126Q	0.2
CESC	chr2	43224077	3'UTR	novel		0.48
CESC	chr2	43226285	Missense_Mutation	rs763421001	D11N	0.09
CESC	chr2	43225390	Silent	NA	Q138Q	0.49
CESC	chr2	43225403	Missense_Mutation	rs761179005	L134H	0.54
CESC	chr2	43224850	Silent	novel	A318A	0.6
CESC	chr2	43225667	Missense_Mutation	NA	S46L	0.15
CESC	chr2	43225381	Missense_Mutation	novel	Q141H	0.32
CESC	chr2	43225169	Missense_Mutation	novel	C212Y	0.46	zf-CCCH
CESC	chr2	43225225	Missense_Mutation	NA	K193N	0.26	zf-CCCH
CESC	chr2	43226392	5'UTR	novel		0.27
CESC	chr2	43225260	Missense_Mutation	NA	E182K	0.37
CHOL	chr2	43223769	3'UTR	novel		0.46
COAD	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.16
COAD	chr2	43224218	3'UTR	novel		0.57
COAD	chr2	43225502	Frame_Shift_Del	novel	*Y98Lfs86**	0.3
COAD	chr2	43225512	Frame_Shift_Del	novel	*Y98Rfs4**	0.14
COAD	chr2	43225162	Frame_Shift_Ins	novel	*I215Hfs259**	0.31	zf-CCCH
COAD	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.33
COAD	chr2	43225372	Frame_Shift_Ins	novel	*G145Rfs329**	0.41
COAD	chr2	43225449	Frame_Shift_Ins	novel	*F119Ifs7**	0.3
COAD	chr2	43224321	Nonstop_Mutation	NA	495Rext81	0.67
COAD	chr2	43225286	Frame_Shift_Del	novel	*K173Vfs300**	0.38
COAD	chr2	43225484	Frame_Shift_Del	rs765083004	*G107Afs80**	0.52
COAD	chr2	43224218	3'UTR	novel		0.56
COAD	chr2	43224218	3'UTR	novel		0.38
COAD	chr2	43225199	Frame_Shift_Del	novel	*H201Pfs259**	0.56	zf-CCCH
COAD	chr2	43225532	Frame_Shift_Del	novel	*S89Gfs11**	0.44
COAD	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.09
COAD	chr2	43225352	Frame_Shift_Ins	NA	*S151Yfs323**	0.23
COAD	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.58
COAD	chr2	43225498	Frame_Shift_Ins	NA	*E103Gfs23**	1
COAD	chr2	43225484	Frame_Shift_Del	rs765083004	*G107Afs80**	0.86
COAD	chr2	43225393	Frame_Shift_Ins	NA	*Q138Afs336**	0.38
COAD	chr2	43224218	3'UTR	novel		0.56
COAD	chr2	43225319	Frame_Shift_Ins	novel	*F162Sfs314**	0.37
COAD	chr2	43226380	5'UTR	NA		0.23
COAD	chr2	43225362	Nonsense_Mutation	NA	Q148*	0.5
COAD	chr2	43224218	3'UTR	novel		0.46
COAD	chr2	43225483	Frame_Shift_Ins	rs749991294	*G108Rfs18**	0.26
COAD	chr2	43225496	Frame_Shift_Ins	NA	*E103Gfs23**	0.32
COAD	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.19
COAD	chr2	43224218	3'UTR	novel		0.57
ESCA	chr2	43226373	5'UTR	novel		0.08
ESCA	chr2	43226329	5'UTR	novel		0.13
ESCA	chr2	43223539	3'UTR	novel		0.71
ESCA	chr2	43225300	Frame_Shift_Ins	novel	*K169Afs19**	0.13
GBM	chr2	43225199	Missense_Mutation	novel	T202S	0.67	zf-CCCH
HNSC	chr2	43224703	Silent	novel	P367P	0.39
HNSC	chr2	43225372	Frame_Shift_Ins	novel	*G145Rfs329**	0.79
HNSC	chr2	43225416	Frame_Shift_Ins	novel	*R130Sfs344**	0.41
HNSC	chr2	43225325	Frame_Shift_Ins	NA	*R160Pfs314**	0.33
HNSC	chr2	43225094	Frame_Shift_Ins	novel	*G237Vfs225**	0.43
HNSC	chr2	43225405	Frame_Shift_Ins	novel	*H133Qfs341**	0.44
HNSC	chr2	43225162	Frame_Shift_Ins	novel	*F214Lfs260**	0.58	zf-CCCH
HNSC	chr2	43225310	Frame_Shift_Del	novel	*T156Rfs308**	0.11
HNSC	chr2	43225086	Missense_Mutation	novel	D240H	0.28
HNSC	chr2	43224269	3'UTR	novel		0.67
HNSC	chr2	43225710	Missense_Mutation	novel	D32N	0.28
KICH	chr2	43226331	5'UTR	novel		0.92
KIRC	chr2	43225031	Missense_Mutation	NA	L258P	0.3
KIRC	chr2	43225331	Missense_Mutation	NA	L158P	0.16
KIRP	chr2	43224761	Frame_Shift_Del	novel	*A340Pfs125**	0.75
KIRP	chr2	43225299	Missense_Mutation	novel	K169E	0.62
LIHC	chr2	43225314	Nonsense_Mutation	novel	E164*	0.38
LIHC	chr2	43225335	Missense_Mutation	NA	E157Q	0.25
LUAD	chr2	43225059	Missense_Mutation	NA	E249Q	0.14
LUAD	chr2	43225468	Silent	novel	L112L	0.13
LUAD	chr2	43225692	Frame_Shift_Ins	NA	*T38Dfs46**	0.44
LUSC	chr2	43224917	Missense_Mutation	novel	A296G	0.36
LUSC	chr2	43225242	Missense_Mutation	novel	R188C	0.38
LUSC	chr2	43225086	Missense_Mutation	NA	D240N	0.5
LUSC	chr2	43225322	Missense_Mutation	NA	P161R	0.42
LUSC	chr2	43225750	Splice_Region	NA	T18T	0.59
LUSC	chr2	43224907	In_Frame_Ins	novel	S298_C299insWS	0.49
LUSC	chr2	43225086	Missense_Mutation	NA	D240N	0.11
LUSC	chr2	43225335	Missense_Mutation	NA	E157Q	0.44
LUSC	chr2	43225372	Frame_Shift_Ins	novel	*G145Rfs329**	0.46
OV	chr2	43224180	3'UTR	novel		0.71
OV	chr2	43225314	Nonsense_Mutation	novel	E164*	0.26
PAAD	chr2	43225484	Frame_Shift_Del	rs765083004	*G107Afs80**	0.16
PAAD	chr2	43224328	Silent	novel	S492S	0.25
PAAD	chr2	43226270	Missense_Mutation	novel	C16R	0.09
PRAD	chr2	43225372	Frame_Shift_Ins	novel	*G145Afs43**	0.71
PRAD	chr2	43224997	Silent	novel	Q269Q	0.33
PRAD	chr2	43225193	Missense_Mutation	novel	G204D	0.36	zf-CCCH
READ	chr2	43225325	Frame_Shift_Ins	NA	*R160Pfs314**	0.37
READ	chr2	43225203	Frame_Shift_Ins	NA	*H201Sfs273**	0.71	zf-CCCH
READ	chr2	43225300	Frame_Shift_Ins	NA	*C168Wfs306**	0.33
READ	chr2	43225325	Frame_Shift_Ins	NA	*R160Pfs314**	0.41
READ	chr2	43225442	Frame_Shift_Ins	NA	*D121Gfs5**	0.28
READ	chr2	43225185	Frame_Shift_Ins	novel	*P207Afs255**	0.45	zf-CCCH
SKCM	chr2	43224884	Missense_Mutation	NA	S307F	0.45
SKCM	chr2	43225372	Frame_Shift_Ins	novel	*G145Rfs329**	0.39
SKCM	chr2	43225343	Missense_Mutation	novel	Y154F	0.31
SKCM	chr2	43225127	Missense_Mutation	NA	S226L	0.62
SKCM	chr2	43224321	Nonstop_Mutation	NA	495Rext81	0.38
SKCM	chr2	43225274	Frame_Shift_Del	novel	*K173Afs296**	0.31
STAD	chr2	43225093	Silent	rs767426655	G237G	0.09
STAD	chr2	43225325	Frame_Shift_Ins	NA	*R160Pfs314**	0.27
STAD	chr2	43225484	Frame_Shift_Del	rs765083004	*G107Afs80**	0.3
STAD	chr2	43225178	Missense_Mutation	novel	G209V	0.41	zf-CCCH
STAD	chr2	43225121	Frame_Shift_Del	NA	*G228Afs233**	0.29
STAD	chr2	43225158	Missense_Mutation	novel	H216Y	0.5	zf-CCCH
STAD	chr2	43225484	Frame_Shift_Del	rs765083004	*G107Afs80**	0.32
STAD	chr2	43225483	Frame_Shift_Ins	rs749991294	*G108Rfs18**	0.44
STAD	chr2	43225701	Missense_Mutation	rs766861473	A35T	0.28
STAD	chr2	43225692	Frame_Shift_Ins	NA	*T38Dfs46**	0.28
STAD	chr2	43225716	Missense_Mutation	rs745522686	M30V	0.5
STAD	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.59
STAD	chr2	43225301	Missense_Mutation	NA	C168Y	0.34
STAD	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.44
STAD	chr2	43225532	Frame_Shift_Del	novel	*S89Gfs11**	0.18
THCA	chr2	43225287	In_Frame_Ins	novel	E172dup	0.08
THCA	chr2	43224984	Missense_Mutation	NA	L274F	0.55
UCEC	chr2	43223711	3'UTR	novel		0.27
UCEC	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.34
UCEC	chr2	43225225	Silent	rs754654347	K193K	0.21
UCEC	chr2	43224106	3'UTR	novel		0.72
UCEC	chr2	43225199	Missense_Mutation	novel	T202N	0.48	zf-CCCH
UCEC	chr2	43225689	Frame_Shift_Ins	NA	*P39Gfs150**	0.19
UCEC	chr2	43225142	Missense_Mutation	novel	R221Q	0.5
UCEC	chr2	43226375	5'UTR	novel		0.4
UCEC	chr2	43226292	Silent	NA	A8A	0.25
UCEC	chr2	43226442	5'UTR	novel		0.5
UCEC	chr2	43224106	3'UTR	novel		0.43
UCEC	chr2	43224814	Frame_Shift_Del	novel	*A325Gfs143**	1
UCEC	chr2	43225373	Frame_Shift_Del	NA	*G144Afs43**	0.36
UCEC	chr2	43223597	3'UTR	novel		0.17
UCEC	chr2	43225219	Missense_Mutation	novel	E195D	0.28	zf-CCCH
UCEC	chr2	43225220	Missense_Mutation	novel	E195V	0.28	zf-CCCH
UCEC	chr2	43225343	Missense_Mutation	NA	Y154C	0.3
UCEC	chr2	43224132	3'UTR	novel		0.38
UCEC	chr2	43223575	3'UTR	novel		0.35
UCEC	chr2	43225121	Frame_Shift_Del	NA	*G228Afs233**	0.14
UCEC	chr2	43226274	Missense_Mutation	NA	F14L	0.11
UCEC	chr2	43225692	Frame_Shift_Ins	NA	*T38Dfs46**	0.52
UCEC	chr2	43226350	5'UTR	novel		0.39
UCEC	chr2	43225662	Frame_Shift_Ins	novel	*F48Lfs36**	0.4
UCEC	chr2	43225328	Missense_Mutation	novel	C159Y	0.36
UCEC	chr2	43225296	Missense_Mutation	novel	Y170H	0.29
UCEC	chr2	43225268	Missense_Mutation	novel	G179D	0.06
UCS	chr2	43224362	Missense_Mutation	novel	R481H	0.36
UCS	chr2	43225121	Frame_Shift_Del	NA	*G228Afs233**	0.44
UCS	chr2	43225053	Missense_Mutation	novel	R251W	0.56

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2271	0.099937
COAD	DEL	0.0355	0.15521
ESCA	DEL	0.0543	0.060925
KIRP	DEL	0.0208	0.08832
PAAD	AMP	0.0326	0.021017
PAAD	DEL	0.0707	0.2014
PRAD	AMP	0.0163	0.00020824
PRAD	DEL	0.0711	0.096106
READ	DEL	0.0848	0.20625
TGCT	AMP	0.26	0.0050216

Survival Analysis

Cancer	P-value	Q-value
THYM	0.012	Kaplan-Meier Survival Analysis
KIRC	0.00042	Kaplan-Meier Survival Analysis
STAD	0.031	Kaplan-Meier Survival Analysis
ACC	0.00023	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
LUSC	0.0049	Kaplan-Meier Survival Analysis
PAAD	0.018	Kaplan-Meier Survival Analysis
CESC	0.036	Kaplan-Meier Survival Analysis
UVM	0.0022	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152518 (Gene tree)
Gene ID: 678
Gene Symbol: ZFP36L2
Alias: ERF2|RNF162C|TIS11D|BRF2
Full Name: ZFP36 ring finger protein like 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,208 bases
Position: chr2:43,222,402-43,226,609
Accession: 1108
RBP type: canonical RBP
Summary: This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000282388	zf-CCCH	PF00642.24	8.7e-21	1	2
ENSP00000282388	zf-CCCH	PF00642.24	8.7e-21	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19633199	Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.	Blood	2009 Sep 17	Stumpo DJ	doi: 10.1182/blood-2009-04-214619
20506496	A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d.	Protein Sci	2010 Jun	Morgan BR	doi: 10.1002/pro.401.
11796723	Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling.	J Biol Chem	2002 Mar 29	Phillips RS	-
14981510	Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.	Nat Struct Mol Biol	2004 Mar	Hudson BP	-
19801654	Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia.	J Biol Chem	2009 Nov 20	Sinha S	doi: 10.1074/jbc.M109.058065
21278925	The roles of TTP and BRF proteins in regulated mRNA decay.	Wiley Interdiscip Rev RNA	2011 Jan-Feb	Sanduja S	doi: 10.1002/wrna.28.
21109922	Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia.	Int J Oncol	2011 Jan	Iwanaga E	-
20622884	Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.	Nat Immunol	2010 Aug	Hodson DJ	doi: 10.1038/ni.1901
25505318	An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.	J Neurosci	2014 Dec 10	Cargnin F	doi: 10.1523/JNEUROSCI.1650-14.2014.
24830504	The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.	PLoS One	2014 May 15	Ball CB	doi: 10.1371/journal.pone.0097324
23748442	ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors.	Nature	2013 Jul 4	Zhang L	doi: 10.1038/nature12215
27102483	RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.	Science	2016 Apr 22	Galloway A	doi: 10.1126/science.aad5978.
27566829	The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.	J Immunol	2016 Oct 1	Vogel KU	doi: 10.4049/jimmunol.1600854
28451295	Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequences.	Chem Sci	2017 Feb 1	Raibaut L	doi: 10.1039/c6sc04086a
29408237	Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2.	Dev Cell	2018 Feb 5	Dumdie JN	doi: 10.1016/j.devcel.2018.01.006
29449217	ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.	Biol Open	2018 Mar 12	Noguchi A	doi: 10.1242/bio.031575.
30478191	CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte.	EMBO J	2018 Dec 14	Sha QQ	doi: 10.15252/embj.201899333
30526691	The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis.	Skelet Muscle	2018 Dec 7	Bye-A-Jee H	doi: 10.1186/s13395-018-0183-9.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000282388	ZFP36L2-201	3696	-	ENSP00000282388	494 (aa)	-	P47974

Gene Model

Click here to download ENSG00000152518's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04218	Cellular senescence	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000152518	rs149290349	2	43224818	A	Lymphocyte counts	27863252	[0.059-0.086] unit decrease	0.07242298	EFO_0004587
ENSG00000152518	rs149290349	2	43224818	A	Lymphocyte percentage of white cells	27863252	[0.076-0.103] unit decrease	0.08961224	EFO_0007993
ENSG00000152518	rs149290349	2	43224818	A	Neutrophil percentage of white cells	27863252	[0.074-0.101] unit increase	0.08704756	EFO_0007990
ENSG00000152518	rs149290349	2	43224818	A	Neutrophil percentage of granulocytes	27863252	[0.027-0.054] unit increase	0.0405918	EFO_0007994
ENSG00000152518	rs149290349	2	43224818	A	Platelet count	27863252	[0.069-0.097] unit decrease	0.08271724	EFO_0004309
ENSG00000152518	rs149290349	2	43224818	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152518's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000152518	ZFP36L2	75	60.241	ENSG00000185650	ZFP36L1	60	75.893

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152518	ZFP36L2	100	49.222	ENSAPOG00000004647	zfp36l2	61	55.892	Acanthochromis_polyacanthus
ENSG00000152518	ZFP36L2	84	88.218	ENSAMEG00000005597	ZFP36L2	78	88.000	Ailuropoda_melanoleuca
ENSG00000152518	ZFP36L2	100	49.130	ENSACIG00000014285	zfp36l2	63	56.566	Amphilophus_citrinellus
ENSG00000152518	ZFP36L2	100	49.513	ENSAOCG00000011193	zfp36l2	61	56.419	Amphiprion_ocellaris
ENSG00000152518	ZFP36L2	100	49.513	ENSAPEG00000006879	zfp36l2	61	56.419	Amphiprion_percula
ENSG00000152518	ZFP36L2	100	49.624	ENSATEG00000009119	zfp36l2	62	54.045	Anabas_testudineus
ENSG00000152518	ZFP36L2	82	68.056	ENSACAG00000014740	ZFP36L2	75	83.099	Anolis_carolinensis
ENSG00000152518	ZFP36L2	100	98.785	ENSANAG00000025228	ZFP36L2	100	98.785	Aotus_nancymaae
ENSG00000152518	ZFP36L2	100	49.421	ENSACLG00000015842	zfp36l2	61	55.369	Astatotilapia_calliptera
ENSG00000152518	ZFP36L2	68	75.410	ENSAMXG00000040114	zfp36l2	79	62.295	Astyanax_mexicanus
ENSG00000152518	ZFP36L2	56	53.041	ENSAMXG00000043777	ZFP36L2	79	76.923	Astyanax_mexicanus
ENSG00000152518	ZFP36L2	100	89.069	ENSBTAG00000003553	ZFP36L2	100	89.879	Bos_taurus
ENSG00000152518	ZFP36L2	100	98.182	ENSCJAG00000014571	ZFP36L2	100	98.182	Callithrix_jacchus
ENSG00000152518	ZFP36L2	100	90.381	ENSCAFG00000031079	ZFP36L2	100	87.575	Canis_familiaris
ENSG00000152518	ZFP36L2	100	90.020	ENSCAFG00020025413	ZFP36L2	100	88.423	Canis_lupus_dingo
ENSG00000152518	ZFP36L2	100	95.951	ENSCHIG00000025020	ZFP36L2	100	95.951	Capra_hircus
ENSG00000152518	ZFP36L2	78	76.826	ENSCPOG00000022038	ZFP36L2	91	78.663	Cavia_porcellus
ENSG00000152518	ZFP36L2	100	98.785	ENSCCAG00000027388	ZFP36L2	100	98.785	Cebus_capucinus
ENSG00000152518	ZFP36L2	100	98.381	ENSCATG00000009833	ZFP36L2	100	98.381	Cercocebus_atys
ENSG00000152518	ZFP36L2	100	98.988	ENSCSAG00000012709	ZFP36L2	100	98.988	Chlorocebus_sabaeus
ENSG00000152518	ZFP36L2	100	58.029	ENSCPBG00000005249	ZFP36L2	94	65.248	Chrysemys_picta_bellii
ENSG00000152518	ZFP36L2	62	100.000	ENSCANG00000039077	ZFP36L2	100	100.000	Colobus_angolensis_palliatus
ENSG00000152518	ZFP36L2	100	88.129	ENSCGRG00001023281	Zfp36l2	100	88.531	Cricetulus_griseus_chok1gshd
ENSG00000152518	ZFP36L2	56	52.381	ENSCSEG00000000741	zfp36l2	63	51.746	Cynoglossus_semilaevis
ENSG00000152518	ZFP36L2	100	42.262	ENSDARG00000021806	zfp36l2	81	66.102	Danio_rerio
ENSG00000152518	ZFP36L2	56	98.485	ENSDNOG00000043725	ZFP36L2	70	98.485	Dasypus_novemcinctus
ENSG00000152518	ZFP36L2	58	98.611	ENSDORG00000027040	Zfp36l2	98	98.485	Dipodomys_ordii
ENSG00000152518	ZFP36L2	100	94.790	ENSEASG00005005027	ZFP36L2	70	95.190	Equus_asinus_asinus
ENSG00000152518	ZFP36L2	97	94.045	ENSECAG00000017795	ZFP36L2	95	94.661	Equus_caballus
ENSG00000152518	ZFP36L2	100	49.509	ENSELUG00000000600	zfp36l2	76	69.231	Esox_lucius
ENSG00000152518	ZFP36L2	100	94.821	ENSFCAG00000043567	ZFP36L2	100	94.821	Felis_catus
ENSG00000152518	ZFP36L2	100	50.888	ENSFHEG00000020530	zfp36l2	78	67.164	Fundulus_heteroclitus
ENSG00000152518	ZFP36L2	100	54.850	ENSGALG00000033129	ZFP36L2	94	66.912	Gallus_gallus
ENSG00000152518	ZFP36L2	100	93.725	ENSGGOG00000001402	ZFP36L2	100	93.725	Gorilla_gorilla
ENSG00000152518	ZFP36L2	100	49.035	ENSHBUG00000007929	zfp36l2	61	55.184	Haplochromis_burtoni
ENSG00000152518	ZFP36L2	100	78.304	ENSHGLG00000005547	ZFP36L2	100	79.200	Heterocephalus_glaber_female
ENSG00000152518	ZFP36L2	100	44.689	ENSHCOG00000006757	zfp36l2	79	73.770	Hippocampus_comes
ENSG00000152518	ZFP36L2	100	95.354	ENSSTOG00000024603	ZFP36L2	100	95.354	Ictidomys_tridecemlineatus
ENSG00000152518	ZFP36L2	81	79.693	ENSJJAG00000024221	Zfp36l2	100	80.827	Jaculus_jaculus
ENSG00000152518	ZFP36L2	55	54.982	ENSKMAG00000011495	zfp36l2	86	60.606	Kryptolebias_marmoratus
ENSG00000152518	ZFP36L2	100	93.186	ENSLAFG00000004265	ZFP36L2	100	93.186	Loxodonta_africana
ENSG00000152518	ZFP36L2	100	98.785	ENSMFAG00000001243	ZFP36L2	100	98.785	Macaca_fascicularis
ENSG00000152518	ZFP36L2	100	98.583	ENSMMUG00000042653	ZFP36L2	100	98.583	Macaca_mulatta
ENSG00000152518	ZFP36L2	100	99.190	ENSMNEG00000034994	ZFP36L2	100	99.190	Macaca_nemestrina
ENSG00000152518	ZFP36L2	100	50.484	ENSMAMG00000010793	zfp36l2	61	57.239	Mastacembelus_armatus
ENSG00000152518	ZFP36L2	100	49.421	ENSMZEG00005018129	zfp36l2	61	55.369	Maylandia_zebra
ENSG00000152518	ZFP36L2	99	41.547	ENSMAUG00000002048	-	53	47.552	Mesocricetus_auratus
ENSG00000152518	ZFP36L2	100	96.378	ENSMICG00000034373	ZFP36L2	100	96.378	Microcebus_murinus
ENSG00000152518	ZFP36L2	100	80.040	ENSMICG00000004731	-	100	79.032	Microcebus_murinus
ENSG00000152518	ZFP36L2	100	90.909	ENSMOCG00000011066	Zfp36l2	100	90.505	Microtus_ochrogaster
ENSG00000152518	ZFP36L2	100	62.427	ENSMODG00000000407	ZFP36L2	98	65.116	Monodelphis_domestica
ENSG00000152518	ZFP36L2	54	47.826	ENSMALG00000005933	zfp36l2	60	47.431	Monopterus_albus
ENSG00000152518	ZFP36L2	100	83.936	MGP_CAROLIEiJ_G0021921	Zfp36l2	100	86.948	Mus_caroli
ENSG00000152518	ZFP36L2	100	82.932	ENSMUSG00000045817	Zfp36l2	100	86.145	Mus_musculus
ENSG00000152518	ZFP36L2	100	86.318	MGP_PahariEiJ_G0020911	Zfp36l2	100	88.732	Mus_pahari
ENSG00000152518	ZFP36L2	100	83.367	MGP_SPRETEiJ_G0022837	Zfp36l2	100	85.170	Mus_spretus
ENSG00000152518	ZFP36L2	99	93.775	ENSMPUG00000011587	ZFP36L2	99	93.173	Mustela_putorius_furo
ENSG00000152518	ZFP36L2	51	81.323	ENSMLUG00000015588	-	73	80.934	Myotis_lucifugus
ENSG00000152518	ZFP36L2	100	88.330	ENSNGAG00000001096	Zfp36l2	100	89.336	Nannospalax_galili
ENSG00000152518	ZFP36L2	100	49.904	ENSNBRG00000019818	zfp36l2	61	56.040	Neolamprologus_brichardi
ENSG00000152518	ZFP36L2	100	97.782	ENSNLEG00000016712	ZFP36L2	100	97.782	Nomascus_leucogenys
ENSG00000152518	ZFP36L2	53	81.387	ENSMEUG00000010649	ZFP36L2	100	68.110	Notamacropus_eugenii
ENSG00000152518	ZFP36L2	100	49.421	ENSONIG00000002997	zfp36l2	61	55.853	Oreochromis_niloticus
ENSG00000152518	ZFP36L2	55	57.348	ENSOANG00000002848	-	80	60.573	Ornithorhynchus_anatinus
ENSG00000152518	ZFP36L2	57	91.003	ENSOCUG00000029169	ZFP36L2	79	91.696	Oryctolagus_cuniculus
ENSG00000152518	ZFP36L2	100	94.366	ENSOGAG00000028804	ZFP36L2	84	95.171	Otolemur_garnettii
ENSG00000152518	ZFP36L2	70	100.000	ENSPPAG00000031644	-	76	100.000	Pan_paniscus
ENSG00000152518	ZFP36L2	100	94.012	ENSPPRG00000012511	ZFP36L2	100	94.012	Panthera_pardus
ENSG00000152518	ZFP36L2	100	99.393	ENSPTRG00000051255	ZFP36L2	100	99.393	Pan_troglodytes
ENSG00000152518	ZFP36L2	100	98.988	ENSPANG00000018603	ZFP36L2	100	98.988	Papio_anubis
ENSG00000152518	ZFP36L2	100	50.000	ENSPKIG00000022742	zfp36l2	100	47.573	Paramormyrops_kingsleyae
ENSG00000152518	ZFP36L2	64	60.377	ENSPKIG00000009699	-	63	42.322	Paramormyrops_kingsleyae
ENSG00000152518	ZFP36L2	100	49.802	ENSPMGG00000018810	zfp36l2	60	57.193	Periophthalmus_magnuspinnatus
ENSG00000152518	ZFP36L2	88	96.970	ENSPEMG00000018068	Zfp36l2	90	96.970	Peromyscus_maniculatus_bairdii
ENSG00000152518	ZFP36L2	56	59.091	ENSPLAG00000015739	zfp36l2	60	57.343	Poecilia_latipinna
ENSG00000152518	ZFP36L2	56	59.441	ENSPMEG00000013175	-	60	57.692	Poecilia_mexicana
ENSG00000152518	ZFP36L2	56	58.947	ENSPMEG00000008897	zfp36l2	60	57.692	Poecilia_mexicana
ENSG00000152518	ZFP36L2	56	58.824	ENSPREG00000010467	zfp36l2	60	57.439	Poecilia_reticulata
ENSG00000152518	ZFP36L2	68	96.746	ENSPPYG00000012458	-	94	99.371	Pongo_abelii
ENSG00000152518	ZFP36L2	76	90.074	ENSPCAG00000010765	ZFP36L2	68	96.970	Procavia_capensis
ENSG00000152518	ZFP36L2	100	97.177	ENSPCOG00000015409	ZFP36L2	100	97.177	Propithecus_coquereli
ENSG00000152518	ZFP36L2	100	46.139	ENSPNAG00000013174	ZFP36L2	82	69.231	Pygocentrus_nattereri
ENSG00000152518	ZFP36L2	73	77.049	ENSPNAG00000009692	zfp36l2	64	45.552	Pygocentrus_nattereri
ENSG00000152518	ZFP36L2	100	89.676	ENSRNOG00000005067	Zfp36l2	100	90.081	Rattus_norvegicus
ENSG00000152518	ZFP36L2	100	89.879	ENSRNOG00000050108	LOC100911319	100	90.283	Rattus_norvegicus
ENSG00000152518	ZFP36L2	100	98.000	ENSRBIG00000026428	ZFP36L2	100	98.000	Rhinopithecus_bieti
ENSG00000152518	ZFP36L2	100	98.193	ENSRROG00000042023	ZFP36L2	100	98.193	Rhinopithecus_roxellana
ENSG00000152518	ZFP36L2	67	99.398	ENSSBOG00000020271	ZFP36L2	95	99.398	Saimiri_boliviensis_boliviensis
ENSG00000152518	ZFP36L2	71	57.143	ENSSFOG00015008894	zfp36l2	80	73.770	Scleropages_formosus
ENSG00000152518	ZFP36L2	100	49.609	ENSSDUG00000000788	zfp36l2	61	56.081	Seriola_dumerili
ENSG00000152518	ZFP36L2	100	49.416	ENSSLDG00000001126	zfp36l2	61	55.219	Seriola_lalandi_dorsalis
ENSG00000152518	ZFP36L2	100	53.571	ENSSPUG00000009625	ZFP36L2	82	92.424	Sphenodon_punctatus
ENSG00000152518	ZFP36L2	100	49.805	ENSSPAG00000009096	zfp36l2	61	56.902	Stegastes_partitus
ENSG00000152518	ZFP36L2	100	97.166	ENSSSCG00000038549	ZFP36L2	100	97.166	Sus_scrofa
ENSG00000152518	ZFP36L2	100	49.904	ENSTRUG00000019626	zfp36l2	61	56.000	Takifugu_rubripes
ENSG00000152518	ZFP36L2	100	48.207	ENSTNIG00000017103	zfp36l2	79	67.692	Tetraodon_nigroviridis
ENSG00000152518	ZFP36L2	59	91.003	ENSTBEG00000012370	ZFP36L2	88	92.391	Tupaia_belangeri
ENSG00000152518	ZFP36L2	100	96.970	ENSTTRG00000006356	ZFP36L2	100	96.970	Tursiops_truncatus
ENSG00000152518	ZFP36L2	100	96.386	ENSUAMG00000024227	ZFP36L2	100	96.386	Ursus_americanus
ENSG00000152518	ZFP36L2	72	89.560	ENSVVUG00000000298	ZFP36L2	59	86.835	Vulpes_vulpes
ENSG00000152518	ZFP36L2	100	55.354	ENSXETG00000009274	zfp36l2	90	64.643	Xenopus_tropicalis
ENSG00000152518	ZFP36L2	63	80.328	ENSXCOG00000006597	zfp36l2	75	72.131	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	-	IEA	Process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	7835719.	TAS	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005515	protein binding	25106868.	IPI	Function
GO:0005634	nucleus	-	ISS	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006402	mRNA catabolic process	-	ISS	Process
GO:0008283	cell proliferation	7835719.	TAS	Process
GO:0009611	response to wounding	27182009.	IDA	Process
GO:0017091	AU-rich element binding	20506496.	IDA	Function
GO:0030097	hemopoiesis	-	ISS	Process
GO:0033077	T cell differentiation in thymus	-	ISS	Process
GO:0035019	somatic stem cell population maintenance	-	ISS	Process
GO:0035925	mRNA 3'-UTR AU-rich region binding	25106868.	IDA	Function
GO:0043488	regulation of mRNA stability	25106868.	IMP	Process
GO:0043488	regulation of mRNA stability	-	ISS	Process
GO:0044344	cellular response to fibroblast growth factor stimulus	20166898.	IDA	Process
GO:0045577	regulation of B cell differentiation	-	ISS	Process
GO:0045599	negative regulation of fat cell differentiation	-	ISS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048103	somatic stem cell division	-	ISS	Process
GO:0060216	definitive hemopoiesis	-	ISS	Process
GO:0061158	3'-UTR-mediated mRNA destabilization	21873635.	IBA	Process
GO:0061158	3'-UTR-mediated mRNA destabilization	25106868.	IMP	Process
GO:0061158	3'-UTR-mediated mRNA destabilization	-	ISS	Process
GO:0070371	ERK1 and ERK2 cascade	25106868.	IDA	Process
GO:0071356	cellular response to tumor necrosis factor	20166898.	IDA	Process
GO:0071364	cellular response to epidermal growth factor stimulus	20166898.	IDA	Process
GO:0071385	cellular response to glucocorticoid stimulus	20166898.	IDA	Process
GO:0071560	cellular response to transforming growth factor beta stimulus	20166898.	IDA	Process
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	20166898.	IDA	Process
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	-	ISS	Process
GO:1901991	negative regulation of mitotic cell cycle phase transition	-	ISS	Process
GO:2000737	negative regulation of stem cell differentiation	-	ISS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

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Expression

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Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.