EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24684457	ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.	J Clin Endocrinol Metab	2014 Jul	Qiang W	doi: 10.1210/jc.2013-3729
23774800	Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers.	Epigenetics	2013 Jun	Huang RL	doi: 10.4161/epi.24816
19135984	ZIC1 is downregulated through promoter hypermethylation in gastric cancer.	Biochem Biophys Res Commun	2009 Feb 20	Wang LJ	doi: 10.1016/j.bbrc.2008.12.180
29956756	ZIC1 acts a tumor suppressor in breast cancer by targeting survivin.	Int J Oncol	2018 Sep	Han W	doi: 10.3892/ijo.2018.4450
21347233	ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer.	PLoS One	2011 Feb 15	Gan L	doi: 10.1371/journal.pone.0016916.
26670443	Clinicopathological significance of increased ZIC1 expression in human endometrial cancer.	J Huazhong Univ Sci Technolog Med Sci	2015 Dec	Gu X	doi: 10.1007/s11596-015-1525-z
25953442	Screening the molecular targets of ovarian cancer based on bioinformatics analysis.	Tumori	2015 Jul-Aug	Du L	doi: 10.5301/tj.5000319
26207911	Zic1 Promoter Hypermethylation in Plasma DNA Is a Potential Biomarker for Gastric Cancer and Intraepithelial Neoplasia.	PLoS One	2015 Jul 24	Chen X	doi: 10.1371/journal.pone.0133906
22799764	ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer.	BMC Cancer	2012 Jul 16	Zhong J	doi: 10.1186/1471-2407-12-290.
28119363	Genome-wide DNA Methylation Profiling Reveals Methylation Markers Associated with 3q Gain for Detection of Cervical Precancer and Cancer.	Clin Cancer Res	2017 Jul 15	Verlaat W	doi: 10.1158/1078-0432.CCR-16-2641

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	147410737	Missense_Mutation	NA	G209C	0.17
BLCA	chr3	147410306	Missense_Mutation	novel	T65M	0.13	zf-C2H2
BLCA	chr3	147412595	Missense_Mutation	novel	H354Y	0.26
BLCA	chr3	147410947	Missense_Mutation	novel	E279K	0.21
BLCA	chr3	147413439	Missense_Mutation	NA	S411F	0.13
BLCA	chr3	147410447	Missense_Mutation	NA	A112V	0.09
BLCA	chr3	147410124	Silent	novel	D4D	0.56
BLCA	chr3	147410167	Missense_Mutation	NA	A19T	0.24
BLCA	chr3	147412667	Missense_Mutation	NA	R378C	0.13
BLCA	chr3	147410756	Missense_Mutation	NA	R215H	0.1
BLCA	chr3	147411006	Silent	NA	G298G	0.32
BLCA	chr3	147410501	Missense_Mutation	novel	G130D	0.16
BLCA	chr3	147410264	Missense_Mutation	NA	P51H	0.33
BLCA	chr3	147410875	Missense_Mutation	NA	H255N	0.38
BLCA	chr3	147410517	Silent	rs369830340	T135T	0.61
BLCA	chr3	147410535	Silent	NA	L141L	0.14
BRCA	chr3	147415162	3'UTR	novel		0.21
BRCA	chr3	147411075	Missense_Mutation	NA	I321M	0.45
BRCA	chr3	147413641	3'UTR	novel		0.1
BRCA	chr3	147413419	Silent	novel	S404S	0.13
BRCA	chr3	147410669	Missense_Mutation	NA	S186L	0.51
BRCA	chr3	147410823	Missense_Mutation	novel	N237K	0.16
CESC	chr3	147410472	Silent	NA	L120L	0.17
CESC	chr3	147415008	3'UTR	novel		0.37
CESC	chr3	147415179	3'UTR	novel		0.29
CESC	chr3	147410497	Missense_Mutation	NA	G129R	0.26
CESC	chr3	147412538	Missense_Mutation	novel	E335K	0.41
CESC	chr3	147412674	Missense_Mutation	novel	H380R	0.1
CESC	chr3	147410973	Silent	NA	Y287Y	0.21
CESC	chr3	147413403	Missense_Mutation	NA	S399F	0.21
CESC	chr3	147410385	Silent	novel	S91S	0.31
CESC	chr3	147412564	Silent	NA	F343F	0.23
CESC	chr3	147413476	Silent	rs748925382	S423S	0.18
CESC	chr3	147414403	3'UTR	novel		0.19
COAD	chr3	147411083	Missense_Mutation	NA	R324M	0.35
COAD	chr3	147412577	Missense_Mutation	NA	D348N	0.14
COAD	chr3	147410681	Missense_Mutation	NA	A190D	0.28
COAD	chr3	147410439	Silent	novel	D109D	0.21
COAD	chr3	147410729	Missense_Mutation	NA	A206V	0.53
COAD	chr3	147410403	Silent	novel	T97T	0.35
COAD	chr3	147412631	Missense_Mutation	rs756221956	M366V	0.25
COAD	chr3	147410405	Missense_Mutation	novel	R98Q	0.3
COAD	chr3	147410647	Missense_Mutation	NA	G179S	0.14
COAD	chr3	147412678	Missense_Mutation	NA	M381I	0.17
COAD	chr3	147411055	Missense_Mutation	NA	R315C	0.29
COAD	chr3	147413570	3'UTR	novel		0.48
COAD	chr3	147413734	3'UTR	novel		0.43
COAD	chr3	147413700	3'UTR	novel		0.5
COAD	chr3	147410818	Missense_Mutation	NA	A236T	0.05
COAD	chr3	147410742	Silent	NA	A210A	0.15
COAD	chr3	147413480	Missense_Mutation	rs75992939	S425P	0.44
COAD	chr3	147412605	Missense_Mutation	novel	T357M	0.5
DLBC	chr3	147410350	Missense_Mutation	novel	H80N	0.22
DLBC	chr3	147411021	Silent	novel	P303P	0.19
ESCA	chr3	147415051	3'UTR	novel		0.21
ESCA	chr3	147411069	Missense_Mutation	novel	L319F	0.22
ESCA	chr3	147411086	Missense_Mutation	novel	T325M	0.32
ESCA	chr3	147411008	Missense_Mutation	novel	E299G	0.21
ESCA	chr3	147413407	Silent	novel	G400G	0.33
ESCA	chr3	147414339	3'UTR	novel		0.17
ESCA	chr3	147414221	3'UTR	novel		0.33
ESCA	chr3	147415459	3'UTR	novel		0.34
ESCA	chr3	147412598	Missense_Mutation	novel	V355L	0.16
GBM	chr3	147410638	Missense_Mutation	NA	E176K	0.41
GBM	chr3	147410299	Missense_Mutation	NA	A63T	0.51	zf-C2H2
GBM	chr3	147410746	Missense_Mutation	NA	A212T	0.18
GBM	chr3	147412581	Missense_Mutation	NA	R349H	0.25
HNSC	chr3	147410571	Silent	novel	H153H	0.2
HNSC	chr3	147412579	Missense_Mutation	novel	D348E	0.24
HNSC	chr3	147410440	Missense_Mutation	rs138004710	A110T	0.71
HNSC	chr3	147410273	Missense_Mutation	novel	H54R	0.29	zf-C2H2
HNSC	chr3	147413518	Silent	rs564229372	A437A	0.07
HNSC	chr3	147410574	Silent	novel	A154A	0.14
HNSC	chr3	147410180	Missense_Mutation	novel	H23L	0.39
HNSC	chr3	147410471	Missense_Mutation	novel	L120P	0.28
HNSC	chr3	147412557	Missense_Mutation	novel	R341P	0.2
HNSC	chr3	147410494	Missense_Mutation	novel	F128I	0.14
HNSC	chr3	147410730	Silent	NA	A206A	0.23
HNSC	chr3	147410631	Silent	rs527947592	P173P	0.1
HNSC	chr3	147413458	Silent	rs758948864	P417P	0.16
HNSC	chr3	147410419	Missense_Mutation	novel	R103G	0.29
HNSC	chr3	147410198	Frame_Shift_Del	novel	*E30Nfs134**	0.09
HNSC	chr3	147410809	Missense_Mutation	novel	E233K	0.16
HNSC	chr3	147410204	Missense_Mutation	novel	R31Q	0.26
HNSC	chr3	147410698	Missense_Mutation	rs764570223	G196S	0.24
HNSC	chr3	147410277	Missense_Mutation	NA	E55D	0.63	zf-C2H2
HNSC	chr3	147411059	Missense_Mutation	NA	S316C	0.5
KIRP	chr3	147410484	Silent	novel	S124S	0.62
KIRP	chr3	147410485	Missense_Mutation	novel	A125S	0.63
KIRP	chr3	147411007	Nonsense_Mutation	NA	E299*	0.22
LIHC	chr3	147410309	Missense_Mutation	novel	S66L	0.38	zf-C2H2
LIHC	chr3	147410850	Silent	NA	F246F	0.26
LIHC	chr3	147413674	3'UTR	novel		0.29
LIHC	chr3	147410873	Missense_Mutation	NA	T254K	0.36
LIHC	chr3	147410725	In_Frame_Del	novel	A206_A210del	0.7
LUAD	chr3	147410825	Missense_Mutation	NA	P238H	0.22
LUAD	chr3	147410522	Frame_Shift_Del	novel	*A138Rfs26**	0.65
LUAD	chr3	147412609	Missense_Mutation	NA	S358R	0.34
LUAD	chr3	147410889	Missense_Mutation	NA	E259D	0.94
LUAD	chr3	147413375	Missense_Mutation	novel	G390S	0.44
LUAD	chr3	147410742	Silent	NA	A210A	0.3
LUAD	chr3	147413384	Missense_Mutation	novel	P393T	0.12
LUAD	chr3	147410919	Missense_Mutation	novel	H269Q	0.13
LUAD	chr3	147410652	Silent	novel	Q180Q	0.25
LUAD	chr3	147412651	Silent	rs147993210	T372T	0.05
LUAD	chr3	147410495	Missense_Mutation	NA	F128Y	0.26
LUAD	chr3	147410497	Missense_Mutation	NA	G129W	0.28
LUAD	chr3	147410655	Silent	rs769657730	V181V	0.14
LUAD	chr3	147410419	Missense_Mutation	NA	R103C	0.13
LUAD	chr3	147411060	Silent	novel	S316S	0.29
LUAD	chr3	147410566	Missense_Mutation	NA	G152C	0.24
LUAD	chr3	147412610	Missense_Mutation	novel	D359Y	0.21
LUAD	chr3	147411056	Missense_Mutation	novel	R315P	0.08
LUAD	chr3	147410545	Missense_Mutation	novel	G145R	0.07
LUAD	chr3	147413401	Missense_Mutation	novel	S398R	0.28
LUAD	chr3	147410903	Missense_Mutation	novel	P264Q	0.15
LUAD	chr3	147413570	3'UTR	novel		0.22
LUAD	chr3	147412553	Missense_Mutation	novel	D340Y	0.25
LUAD	chr3	147410862	Missense_Mutation	novel	H250Q	0.07
LUAD	chr3	147410965	Frame_Shift_Del	novel	*A285Pfs35**	0.06
LUAD	chr3	147413524	Silent	NA	S439S	0.16
LUAD	chr3	147410737	Missense_Mutation	NA	G209C	0.12
LUAD	chr3	147410358	Missense_Mutation	NA	H82Q	0.13
LUAD	chr3	147410890	Missense_Mutation	NA	H260N	0.06
LUAD	chr3	147413596	3'UTR	novel		0.14
LUAD	chr3	147413505	Missense_Mutation	NA	A433D	0.15
LUAD	chr3	147413385	Missense_Mutation	novel	P393L	0.16
LUAD	chr3	147412626	Missense_Mutation	novel	C364S	0.29
LUAD	chr3	147410516	Missense_Mutation	novel	T135K	0.33
LUAD	chr3	147410739	Silent	novel	G209G	0.39
LUAD	chr3	147410583	Missense_Mutation	novel	N157K	0.39
LUAD	chr3	147410385	Missense_Mutation	novel	S91R	0.27
LUAD	chr3	147413637	3'UTR	novel		0.31
LUAD	chr3	147410654	Missense_Mutation	NA	V181E	0.19
LUAD	chr3	147410874	Silent	NA	T254T	0.08
LUAD	chr3	147410329	Missense_Mutation	novel	A73S	0.25
LUAD	chr3	147410277	Missense_Mutation	NA	E55D	0.13	zf-C2H2
LUAD	chr3	147411059	Missense_Mutation	NA	S316C	0.43
LUAD	chr3	147413570	3'UTR	novel		0.19
LUAD	chr3	147410613	Missense_Mutation	novel	F167L	0.39
LUAD	chr3	147410244	Missense_Mutation	NA	M44I	0.09
LUAD	chr3	147412622	Missense_Mutation	NA	L363I	0.16
LUAD	chr3	147411053	Missense_Mutation	NA	A314V	0.41
LUSC	chr3	147410604	Missense_Mutation	NA	R164S	0.44
LUSC	chr3	147412615	Missense_Mutation	NA	K360N	0.11
LUSC	chr3	147411045	Silent	rs748631648	K311K	0.17
LUSC	chr3	147410290	Missense_Mutation	rs748870052	G60C	0.15	zf-C2H2
LUSC	chr3	147410189	Missense_Mutation	novel	G26D	0.33
LUSC	chr3	147411022	Missense_Mutation	novel	C304S	0.27
LUSC	chr3	147413536	Missense_Mutation	rs545219481	N443K	0.22
LUSC	chr3	147410856	Silent	NA	T248T	0.28
LUSC	chr3	147410436	Silent	rs768784777	G108G	0.16
LUSC	chr3	147410592	Missense_Mutation	rs377681059	N160K	0.45
LUSC	chr3	147410775	Missense_Mutation	novel	I221M	0.32
LUSC	chr3	147410382	Silent	rs781380196	S90S	0.17
LUSC	chr3	147411013	Frame_Shift_Del	novel	*C304Afs16**	0.11
LUSC	chr3	147413410	Silent	novel	Y401Y	0.08
LUSC	chr3	147412578	Missense_Mutation	novel	D348G	0.12
LUSC	chr3	147413479	Silent	rs368298985	P424P	0.27
LUSC	chr3	147410573	Missense_Mutation	novel	A154E	0.67
LUSC	chr3	147410425	Silent	NA	R105R	0.29
LUSC	chr3	147410988	Silent	rs780076930	H292H	0.04
LUSC	chr3	147410808	Silent	novel	P232P	0.5
LUSC	chr3	147410658	Silent	novel	T182T	0.25
LUSC	chr3	147410443	Missense_Mutation	novel	A111P	0.27
LUSC	chr3	147410265	Silent	novel	P51P	0.27
LUSC	chr3	147410823	Silent	novel	N237N	0.14
LUSC	chr3	147412528	Silent	novel	P331P	0.31
LUSC	chr3	147412676	Missense_Mutation	NA	M381V	0.1
LUSC	chr3	147410304	Silent	NA	F64F	0.12
LUSC	chr3	147413368	Silent	novel	S387S	0.5
LUSC	chr3	147410701	Missense_Mutation	novel	Y197H	0.19
LUSC	chr3	147410703	Nonsense_Mutation	NA	Y197*	0.15
LUSC	chr3	147410900	Missense_Mutation	novel	G263V	0.22
LUSC	chr3	147411053	Missense_Mutation	NA	A314G	0.22
LUSC	chr3	147410551	Missense_Mutation	novel	H147N	0.31
LUSC	chr3	147410973	Nonsense_Mutation	NA	Y287*	0.28
LUSC	chr3	147413366	Missense_Mutation	novel	S387T	0.35
LUSC	chr3	147410501	Missense_Mutation	NA	G130A	0.11
LUSC	chr3	147410902	Missense_Mutation	novel	P264T	0.13
LUSC	chr3	147410522	Missense_Mutation	NA	A137D	0.29
LUSC	chr3	147410523	Silent	NA	A137A	0.28
LUSC	chr3	147410947	Nonsense_Mutation	novel	E279*	0.2
LUSC	chr3	147412667	Missense_Mutation	novel	R378S	0.21
LUSC	chr3	147410101	5'UTR	novel		0.8
LUSC	chr3	147410407	Missense_Mutation	NA	D99Y	0.11
LUSC	chr3	147410271	Silent	novel	S53S	0.28
LUSC	chr3	147410186	Missense_Mutation	NA	A25V	0.3
LUSC	chr3	147412537	Nonsense_Mutation	NA	C334*	0.27
LUSC	chr3	147410484	Silent	NA	S124S	0.19
LUSC	chr3	147410913	Silent	novel	S267S	0.23
LUSC	chr3	147410738	Missense_Mutation	novel	G209V	0.2
LUSC	chr3	147410208	Missense_Mutation	NA	D32E	0.26
LUSC	chr3	147410371	Missense_Mutation	NA	G87S	0.19
LUSC	chr3	147412650	Missense_Mutation	novel	T372K	0.23
LUSC	chr3	147413463	Missense_Mutation	novel	T419K	0.11
LUSC	chr3	147410141	Missense_Mutation	rs765916669	P10Q	0.25
LUSC	chr3	147413662	3'UTR	novel		0.33
LUSC	chr3	147410361	Silent	novel	P83P	0.14
LUSC	chr3	147412526	Missense_Mutation	novel	P331A	0.7
LUSC	chr3	147413541	Nonsense_Mutation	novel	W445*	0.21
LUSC	chr3	147410747	Missense_Mutation	rs752213758	A212D	0.58
MESO	chr3	147409985	5'UTR	novel		0.5
OV	chr3	147410185	Missense_Mutation	NA	A25T	0.06
OV	chr3	147413456	Missense_Mutation	novel	P417T	0.18
OV	chr3	147410916	Silent	rs753755493	N268N	0.12
PAAD	chr3	147410940	Missense_Mutation	novel	C276W	0.09
PAAD	chr3	147410577	Silent	NA	S155S	0.35
PAAD	chr3	147410104	5'UTR	novel		0.1
PAAD	chr3	147411006	Silent	NA	G298G	0.04
PRAD	chr3	147410448	Silent	rs763182380	A112A	0.38
PRAD	chr3	147412577	Missense_Mutation	NA	D348N	0.17
PRAD	chr3	147413588	3'UTR	novel		0.2
PRAD	chr3	147411006	Silent	NA	G298G	0.05
PRAD	chr3	147410270	Nonsense_Mutation	novel	S53*	0.25	zf-C2H2
PRAD	chr3	147410734	Missense_Mutation	NA	H208N	0.18
PRAD	chr3	147413410	Silent	novel	Y401Y	0.46
READ	chr3	147410850	Missense_Mutation	NA	F246L	0.14
READ	chr3	147410946	Silent	NA	R278R	0.26
READ	chr3	147410948	Missense_Mutation	NA	E279G	0.29
READ	chr3	147412647	Missense_Mutation	NA	Y371C	0.33
READ	chr3	147410688	Silent	rs759778746	P192P	0.59
READ	chr3	147413633	3'UTR	novel		0.6
SARC	chr3	147409588	5'UTR	novel		0.44
SKCM	chr3	147410375	Missense_Mutation	NA	S88F	0.38
SKCM	chr3	147413457	Missense_Mutation	novel	P417L	0.32
SKCM	chr3	147411024	Silent	NA	C304C	0.38
SKCM	chr3	147413484	Missense_Mutation	NA	S426F	0.34
SKCM	chr3	147413411	Missense_Mutation	NA	E402K	0.5
SKCM	chr3	147410228	Missense_Mutation	NA	P39L	0.76
SKCM	chr3	147410595	Silent	novel	G161G	0.28
SKCM	chr3	147410726	Frame_Shift_Ins	novel	*A206Efs53**	0.07
SKCM	chr3	147412576	Missense_Mutation	NA	S347R	0.23
SKCM	chr3	147410211	Silent	novel	V33V	0.29
SKCM	chr3	147412660	Silent	novel	S375S	0.49
SKCM	chr3	147412531	Silent	NA	F332F	0.22
SKCM	chr3	147410619	Silent	NA	G169G	0.29
SKCM	chr3	147413537	Missense_Mutation	NA	E444K	0.08
SKCM	chr3	147413594	3'UTR	novel		0.44
SKCM	chr3	147410914	Missense_Mutation	novel	N268H	0.22
SKCM	chr3	147413484	Missense_Mutation	NA	S426F	0.31
STAD	chr3	147410688	Silent	rs759778746	P192P	0.13
STAD	chr3	147413634	3'UTR	novel		0.18
STAD	chr3	147410286	Silent	rs755293143	S58S	0.15
STAD	chr3	147412537	Silent	novel	C334C	0.08
STAD	chr3	147412662	Missense_Mutation	NA	S376L	0.27
STAD	chr3	147410698	Missense_Mutation	rs764570223	G196S	0.16
STAD	chr3	147410727	Silent	novel	A205A	0.13
STAD	chr3	147412527	Missense_Mutation	novel	P331L	0.25
STAD	chr3	147410524	Missense_Mutation	NA	A138T	0.5
STAD	chr3	147410496	Silent	NA	F128F	0.17
STAD	chr3	147410009	5'UTR	novel		0.6
STAD	chr3	147410577	Silent	NA	S155S	0.31
STAD	chr3	147410236	Missense_Mutation	novel	D42N	0.37
STAD	chr3	147410371	Missense_Mutation	NA	G87S	0.42
STAD	chr3	147410958	Silent	NA	P282P	0.21
STAD	chr3	147410873	Missense_Mutation	NA	T254M	0.25
STAD	chr3	147410378	Missense_Mutation	NA	Y89S	0.15
STAD	chr3	147410345	Missense_Mutation	novel	G78D	0.24
STAD	chr3	147410728	Missense_Mutation	NA	A206T	0.29
STAD	chr3	147411055	Missense_Mutation	NA	R315C	0.32
STAD	chr3	147410523	Silent	rs750080738	A137A	0.38
STAD	chr3	147410169	Silent	rs756393471	A19A	0.57
STAD	chr3	147412636	Silent	rs777958545	C367C	0.13
STAD	chr3	147412565	Missense_Mutation	NA	A344T	0.34
STAD	chr3	147410437	Missense_Mutation	NA	D109N	0.2
STAD	chr3	147412668	Missense_Mutation	NA	R378H	0.31
STAD	chr3	147410615	Missense_Mutation	NA	S168L	0.54
STAD	chr3	147410734	Missense_Mutation	NA	H208N	0.36
STAD	chr3	147410825	Missense_Mutation	NA	P238H	0.2
STAD	chr3	147410528	Missense_Mutation	novel	G139D	0.3
STAD	chr3	147410976	Silent	NA	K288K	0.14
STAD	chr3	147410169	Silent	rs756393471	A19A	0.09
STAD	chr3	147410942	Missense_Mutation	NA	P277L	0.06
STAD	chr3	147410385	Silent	novel	S91S	0.44
STAD	chr3	147410247	Silent	NA	G45G	0.41
THCA	chr3	147410271	Silent	NA	S53S	0.41
UCEC	chr3	147409630	5'UTR	novel		0.44
UCEC	chr3	147411056	Missense_Mutation	novel	R315H	0.28
UCEC	chr3	147410862	Silent	novel	H250H	0.4
UCEC	chr3	147414348	3'UTR	novel		0.4
UCEC	chr3	147414776	3'UTR	novel		0.49
UCEC	chr3	147409517	5'UTR	novel		0.19
UCEC	chr3	147410577	Silent	NA	S155S	0.21
UCEC	chr3	147410685	Silent	novel	A191A	0.31
UCEC	chr3	147409445	5'UTR	novel		0.48
UCEC	chr3	147413604	3'UTR	novel		0.45
UCEC	chr3	147414146	3'UTR	novel		0.33
UCEC	chr3	147414371	3'UTR	novel		0.13
UCEC	chr3	147415065	3'UTR	novel		0.4
UCEC	chr3	147413517	Missense_Mutation	rs373965585	A437V	0.2
UCEC	chr3	147409607	5'UTR	novel		0.56
UCEC	chr3	147411095	Splice_Site	novel	X328_splice	0.5
UCEC	chr3	147410525	Missense_Mutation	novel	A138V	0.56
UCEC	chr3	147410885	Missense_Mutation	NA	V258A	0.27
UCEC	chr3	147413569	3'UTR	rs376681983		0.21
UCEC	chr3	147409662	5'UTR	novel		0.2
UCEC	chr3	147410548	Missense_Mutation	NA	L146I	0.31
UCEC	chr3	147410656	Missense_Mutation	novel	T182S	0.5
UCEC	chr3	147414132	3'UTR	novel		0.32
UCEC	chr3	147410587	Missense_Mutation	novel	V159L	0.46
UCEC	chr3	147414518	3'UTR	novel		0.47
UCEC	chr3	147409508	5'UTR	novel		0.32
UCEC	chr3	147414356	3'UTR	novel		0.44
UCEC	chr3	147412548	Missense_Mutation	novel	G338D	0.14
UCEC	chr3	147414193	3'UTR	novel		0.34
UCEC	chr3	147413372	Nonsense_Mutation	novel	Q389*	0.22
UCEC	chr3	147409407	5'UTR	novel		0.08
UCEC	chr3	147409642	5'UTR	novel		0.2
UCEC	chr3	147412667	Missense_Mutation	NA	R378C	0.42
UCEC	chr3	147413518	Silent	novel	A437A	0.38
UCEC	chr3	147410715	Silent	NA	N201N	0.46
UCEC	chr3	147412663	Silent	NA	S376S	0.43
UCEC	chr3	147413360	Missense_Mutation	novel	E385K	0.45
UCEC	chr3	147415051	3'UTR	novel		0.39
UCEC	chr3	147409431	5'UTR	novel		0.42
UCEC	chr3	147411056	Missense_Mutation	novel	R315H	0.6
UCEC	chr3	147413504	Missense_Mutation	novel	A433S	0.59
UCEC	chr3	147414685	3'UTR	novel		0.36
UCEC	chr3	147415259	3'UTR	novel		0.35
UCEC	chr3	147415432	3'UTR	novel		0.09
UCEC	chr3	147414351	3'UTR	novel		0.48
UCEC	chr3	147410945	Missense_Mutation	NA	R278H	0.4
UCEC	chr3	147410706	Silent	rs777295809	G198G	0.13
UCEC	chr3	147415003	3'UTR	novel		0.55
UCEC	chr3	147414685	3'UTR	novel		0.37
UCEC	chr3	147415107	3'UTR	novel		0.64
UCEC	chr3	147412606	Silent	NA	T357T	0.36
UCEC	chr3	147415481	3'UTR	novel		0.37
UCEC	chr3	147412662	Missense_Mutation	NA	S376L	0.27
UCEC	chr3	147414351	3'UTR	novel		0.23
UCEC	chr3	147409506	5'UTR	novel		0.35
UCEC	chr3	147414285	3'UTR	novel		0.43
UCEC	chr3	147414777	3'UTR	novel		0.1
UCEC	chr3	147409517	5'UTR	novel		0.15
UCEC	chr3	147414197	3'UTR	novel		0.32
UCEC	chr3	147410918	Missense_Mutation	novel	H269R	0.38
UCEC	chr3	147414283	3'UTR	novel		0.33
UCEC	chr3	147414659	3'UTR	novel		0.38
UCEC	chr3	147414871	3'UTR	novel		0.34
UCEC	chr3	147415060	3'UTR	novel		0.33
UCEC	chr3	147409457	5'UTR	novel		0.48
UCEC	chr3	147409618	5'UTR	novel		0.33
UCEC	chr3	147412588	Silent	novel	K351K	0.3
UCEC	chr3	147413634	3'UTR	novel		0.31
UCEC	chr3	147414165	3'UTR	novel		0.32
UCEC	chr3	147414534	3'UTR	novel		0.33
UCEC	chr3	147414195	3'UTR	novel		0.35
UCEC	chr3	147414197	3'UTR	novel		0.34
UCEC	chr3	147414493	3'UTR	novel		0.48
UCEC	chr3	147415469	3'UTR	rs111736391		0.42
UCEC	chr3	147414925	3'UTR	novel		0.25
UCEC	chr3	147414254	3'UTR	novel		0.24
UCEC	chr3	147411012	Silent	novel	K300K	0.12
UCEC	chr3	147414165	3'UTR	novel		0.2
UCEC	chr3	147410371	Missense_Mutation	NA	G87S	0.42
UCEC	chr3	147410688	Silent	rs759778746	P192P	0.2
UCEC	chr3	147413371	Silent	novel	S388S	0.16
UCEC	chr3	147415148	3'UTR	novel		0.42
UCEC	chr3	147410755	Missense_Mutation	novel	R215C	0.26
UCEC	chr3	147410944	Missense_Mutation	novel	R278C	0.42
UCEC	chr3	147410370	Silent	novel	V86V	0.3
UCEC	chr3	147414103	3'UTR	novel		0.5
UCEC	chr3	147410884	Missense_Mutation	rs773749583	V258M	0.21
UCEC	chr3	147410994	Silent	novel	R294R	0.1
UCEC	chr3	147410583	Silent	NA	N157N	0.43
UCEC	chr3	147413570	3'UTR	novel		0.53
UCEC	chr3	147414371	3'UTR	novel		0.46
UCEC	chr3	147415381	3'UTR	novel		0.35
UCEC	chr3	147415596	3'UTR	novel		0.23
UCEC	chr3	147414133	3'UTR	novel		0.53

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.1155	0.11092
KIRP	AMP	0.3125	0.15981

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.0047	Kaplan-Meier Survival Analysis
MESO	0.028	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
KIRP	0.0013	Kaplan-Meier Survival Analysis
LGG	0.00021	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152977 (Gene tree)
Gene ID: 7545
Gene Symbol: ZIC1
Alias: ZIC|ZNF201
Full Name: Zic family member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 116,872 bases
Position: chr3:147,393,422-147,510,293
Accession: 12872
RBP type: canonical RBP
Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000282928	zf-C2H2	PF00096.26	2e-20	1	3
ENSP00000282928	zf-C2H2	PF00096.26	2e-20	2	3
ENSP00000282928	zf-C2H2	PF00096.26	2e-20	3	3
ENSP00000419664	zf-C2H2	PF00096.26	1.1e-09	1	2
ENSP00000419664	zf-C2H2	PF00096.26	1.1e-09	2	2
ENSP00000419664	zf-met	PF12874.7	0.00013	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000282928	ZIC1-201	5241	-	ENSP00000282928	447 (aa)	-	Q15915
ENST00000481840	ZIC1-204	418	-	-	- (aa)	-	-
ENST00000472523	ZIC1-202	567	-	-	- (aa)	-	-
ENST00000474034	ZIC1-203	1044	NR_121655	-	- (aa)	-	-
ENST00000488404	ZIC1-205	539	-	ENSP00000419664	136 (aa)	-	H7C5D8

Gene Model

Click here to download ENSG00000152977's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000152977	rs530580221	3	147394469	T	Age at first sexual intercourse	27089180	[0.017-0.034] unit increase	0.0257722	EFO_0009749

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152977's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152977	ZIC1	89	80.165	ENSACIG00000018732	zic1	93	86.280	Amphilophus_citrinellus
ENSG00000152977	ZIC1	70	100.000	ENSCAFG00000032541	-	100	100.000	Canis_familiaris
ENSG00000152977	ZIC1	100	55.670	ENSEBUG00000002180	zic1	100	56.735	Eptatretus_burgeri
ENSG00000152977	ZIC1	100	55.670	ENSEBUG00000006709	zic1	100	56.735	Eptatretus_burgeri
ENSG00000152977	ZIC1	89	97.521	ENSFDAG00000013872	ZIC1	100	99.265	Fukomys_damarensis
ENSG00000152977	ZIC1	100	87.248	ENSKMAG00000011689	zic1	100	86.353	Kryptolebias_marmoratus
ENSG00000152977	ZIC1	92	58.553	ENSOANG00000007365	-	90	69.333	Ornithorhynchus_anatinus
ENSG00000152977	ZIC1	89	81.818	ENSORLG00020012199	zic1	92	82.500	Oryzias_latipes_hni
ENSG00000152977	ZIC1	89	95.868	ENSSHAG00000015025	ZIC1	100	96.133	Sarcophilus_harrisii

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	-	ISS	Function
GO:0003700	DNA-binding transcription factor activity	8542595.	TAS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	8542595.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0007389	pattern specification process	-	ISS	Process
GO:0007417	central nervous system development	21873635.	IBA	Process
GO:0007420	brain development	8542595.	IDA	Process
GO:0007628	adult walking behavior	-	IEA	Process
GO:0008589	regulation of smoothened signaling pathway	-	ISS	Process
GO:0021510	spinal cord development	-	IEA	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0042307	positive regulation of protein import into nucleus	-	ISS	Process
GO:0042472	inner ear morphogenesis	-	ISS	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.