EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22472896	Mena, a new available marker in tumors of salivary glands?	Eur J Histochem	2012 Feb 7	Gurzu S	doi: 10.4081/ejh.2012.e8.
18985426	Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.	Clin Exp Metastasis	2009	Goswami S	doi: 10.1007/s10585-008-9225-8
29439204	hMENA is a key regulator in endothelin-1/β-arrestin1-induced invadopodial function and metastatic process.	Proc Natl Acad Sci U S A	2018 Mar 20	Di Modugno F	doi: 10.1073/pnas.1715998115
25449779	A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer.	Cancer Lett	2015 Jan 28	Nam S	doi: 10.1016/j.canlet.2014.10.038
21209853	The cooperation between hMena overexpression and HER2 signalling in breast cancer.	PLoS One	2010 Dec 30	Di Modugno F	doi: 10.1371/journal.pone.0015852.
25109497	Relative expression of hMena11a and hMenaINV splice isoforms is a useful biomarker in development and progression of human breast carcinoma.	Int J Oncol	2014 Nov	Tanaka N	doi: 10.3892/ijo.2014.2591
22971274	Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer.	Breast Cancer Res	2012 Sep 12	Agarwal S	doi: 10.1186/bcr3318.
25961924	hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.	Oncogene	2016 Feb 18	Trono P	doi: 10.1038/onc.2015.143
16533770	The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors.	Clin Cancer Res	2006 Mar 1	Di Modugno F	-
27597754	5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.	J Cell Biol	2016 Sep 12	Rajadurai CV	doi: 10.1083/jcb.201501003
27748415	The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior.	Sci Rep	2016 Oct 17	Balsamo M	doi: 10.1038/srep35298.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	225514964	Intron	novel		0.35
BLCA	chr1	225530600	Missense_Mutation	novel	Q130E	0.13
BLCA	chr1	225498378	Missense_Mutation	novel	E569D	0.13
BLCA	chr1	225512908	Missense_Mutation	novel	G443S	0.37
BLCA	chr1	225512952	Missense_Mutation	novel	T428R	0.43
BLCA	chr1	225514903	Splice_Region	novel		0.43
BRCA	chr1	225512984	Silent	NA	N417N	0.33
BRCA	chr1	225512923	Missense_Mutation	NA	P438S	0.17
BRCA	chr1	225555081	Splice_Region	NA	V58V	0.18
BRCA	chr1	225519401	Missense_Mutation	NA	R200P	0.11
BRCA	chr1	225497453	3'UTR	novel		0.08
BRCA	chr1	225519400	Silent	NA	R200R	0.3
BRCA	chr1	225554963	Missense_Mutation	NA	N98D	0.44
BRCA	chr1	225512967	Missense_Mutation	NA	S423Y	0.2
BRCA	chr1	225514645	Missense_Mutation	NA	T390I	0.49
BRCA	chr1	225498344	Splice_Region	novel		0.15
BRCA	chr1	225514944	Intron	novel		0.3
CESC	chr1	225555008	Missense_Mutation	novel	A83T	0.24
CESC	chr1	225514722	Silent	NA	P364P	0.52
CESC	chr1	225519219	Missense_Mutation	NA	E261K	0.48
CESC	chr1	225519532	Silent	NA	L156L	0.44
CESC	chr1	225511832	Missense_Mutation	rs549324711	A484T	0.23
CESC	chr1	225494849	3'UTR	novel		0.51
CESC	chr1	225495810	3'UTR	novel		0.24
CESC	chr1	225519367	Silent	rs201432124	E211E	0.15
CESC	chr1	225517717	Intron	NA		0.31
CESC	chr1	225511850	Missense_Mutation	NA	E478K	0.37
CESC	chr1	225497359	3'UTR	novel		0.35
COAD	chr1	225519261	Nonsense_Mutation	NA	R247*	0.12
COAD	chr1	225511831	Missense_Mutation	NA	A484V	0.19
COAD	chr1	225514624	Missense_Mutation	rs781433637	A397V	0.47
COAD	chr1	225505033	Frame_Shift_Del	NA	*N520Ifs39**	0.28
COAD	chr1	225517695	Intron	NA		0.36
COAD	chr1	225514903	Splice_Region	rs763184881		0.34
COAD	chr1	225515031	Intron	novel		0.57
COAD	chr1	225519356	Missense_Mutation	rs149587286	R215H	0.26
COAD	chr1	225514683	Missense_Mutation	NA	F377L	0.39
COAD	chr1	225519414	Frame_Shift_Ins	NA	*Q196Dfs57**	0.22
DLBC	chr1	225514860	Silent	novel	P318P	0.15
ESCA	chr1	225519338	Missense_Mutation	novel	R221H	0.16
ESCA	chr1	225497442	3'UTR	novel		0.19
ESCA	chr1	225496893	3'UTR	novel		0.27
ESCA	chr1	225496876	3'UTR	novel		0.41
ESCA	chr1	225497794	Missense_Mutation	novel	S586N	0.45
ESCA	chr1	225494958	3'UTR	novel		0.44
GBM	chr1	225530574	Missense_Mutation	novel	E138D	0.42
GBM	chr1	225530557	Missense_Mutation	novel	R144I	0.21
HNSC	chr1	225514911	Intron	novel		0.36
HNSC	chr1	225514665	Silent	novel	S383S	0.19
KIRP	chr1	225507948	Splice_Region	novel		0.15
LGG	chr1	225519260	Missense_Mutation	rs780546038	R247Q	0.3
LUAD	chr1	225514976	Intron	novel		0.28
LUAD	chr1	225501026	Missense_Mutation	novel	Q549L	0.3
LUAD	chr1	225515033	Intron	novel		0.15
LUAD	chr1	225512876	Silent	NA	A453A	0.29
LUAD	chr1	225511850	Nonsense_Mutation	NA	E478*	0.3
LUAD	chr1	225519282	Missense_Mutation	rs142024814	R240W	0.06
LUAD	chr1	225497702	3'UTR	novel		0.21
LUSC	chr1	225505003	Missense_Mutation	novel	D530V	0.14
LUSC	chr1	225497687	3'UTR	novel		0.25
LUSC	chr1	225498374	Missense_Mutation	NA	T571S	0.06
OV	chr1	225507954	Missense_Mutation	NA	S512Y	0.26
OV	chr1	225511831	Missense_Mutation	NA	A484V	0.06
OV	chr1	225514610	Silent	NA	R402R	0.48
PRAD	chr1	225511832	Missense_Mutation	NA	A484S	0.25
READ	chr1	225498380	Nonsense_Mutation	novel	E569*	0.36
SARC	chr1	225514763	Missense_Mutation	novel	P351S	0.71
SARC	chr1	225497565	3'UTR	novel		0.33
SKCM	chr1	225501027	Nonsense_Mutation	novel	Q549*	0.37
SKCM	chr1	225512892	Missense_Mutation	NA	M448T	0.53
SKCM	chr1	225514707	Silent	novel	A369A	0.6
SKCM	chr1	225512923	Missense_Mutation	NA	P438S	0.23
SKCM	chr1	225512942	Silent	rs771348565	G431G	0.31
SKCM	chr1	225514796	Missense_Mutation	NA	P340S	0.71
SKCM	chr1	225554992	Missense_Mutation	NA	G88D	0.45
SKCM	chr1	225505008	Silent	NA	S528S	0.48
SKCM	chr1	225514609	Missense_Mutation	NA	R402K	0.23
SKCM	chr1	225514701	Silent	novel	P371P	0.41
SKCM	chr1	225497780	Missense_Mutation	NA	A591S	0.12
SKCM	chr1	225530584	Missense_Mutation	NA	P135L	0.5
STAD	chr1	225498358	Missense_Mutation	novel	E576A	0.28
STAD	chr1	225514905	Splice_Region	novel		0.13
STAD	chr1	225519215	Missense_Mutation	rs370738156	R262H	0.33
STAD	chr1	225519320	Missense_Mutation	NA	Q227R	0.24
STAD	chr1	225567405	Frame_Shift_Ins	novel	*S5Rfs10**	0.1
STAD	chr1	225514833	Silent	novel	S327S	0.39
STAD	chr1	225519216	Missense_Mutation	rs375992317	R262C	0.26
THYM	chr1	225495687	3'UTR	novel		0.06
UCEC	chr1	225515157	Intron	NA		0.57
UCEC	chr1	225486934	3'UTR	novel		0.25
UCEC	chr1	225497100	3'UTR	novel		0.38
UCEC	chr1	225519238	Silent	novel	E254E	0.34
UCEC	chr1	225495582	3'UTR	novel		0.22
UCEC	chr1	225501056	Missense_Mutation	novel	P539L	0.08
UCEC	chr1	225496183	3'UTR	novel		0.26
UCEC	chr1	225554955	Silent	novel	F100F	0.35
UCEC	chr1	225519539	Frame_Shift_Del	novel	*K154Rfs23**	0.08
UCEC	chr1	225496830	3'UTR	novel		0.6
UCEC	chr1	225497532	3'UTR	novel		0.06
UCEC	chr1	225515086	Intron	novel		0.43
UCEC	chr1	225519447	Nonsense_Mutation	NA	R185*	0.34
UCEC	chr1	225555013	Missense_Mutation	NA	R81Q	0.12
UCEC	chr1	225567317	Missense_Mutation	NA	V35F	0.25
UCEC	chr1	225514906	Splice_Region	novel		0.26
UCEC	chr1	225496202	3'UTR	novel		0.3
UCEC	chr1	225497415	3'UTR	novel		0.21
UCEC	chr1	225555049	Missense_Mutation	novel	K69T	0.33
UCEC	chr1	225496526	3'UTR	novel		0.14
UCEC	chr1	225497014	3'UTR	novel		0.22
UCEC	chr1	225495039	3'UTR	novel		0.35
UCEC	chr1	225495775	3'UTR	novel		0.23
UCEC	chr1	225505052	Missense_Mutation	rs751822086	R514W	0.35
UCEC	chr1	225512965	Missense_Mutation	rs762902163	A424T	0.25
UCEC	chr1	225519353	Missense_Mutation	novel	L216P	0.33
UCEC	chr1	225519357	Missense_Mutation	rs138096201	R215C	0.18
UCEC	chr1	225512899	Nonsense_Mutation	novel	E446*	0.5
UCEC	chr1	225554965	Missense_Mutation	novel	A97V	0.55
UCEC	chr1	225512958	Missense_Mutation	novel	S426Y	0.39
UCEC	chr1	225486863	3'UTR	novel		0.37
UCEC	chr1	225514678	Missense_Mutation	novel	L379S	0.32
UCEC	chr1	225554947	Missense_Mutation	NA	A103V	0.38
UCEC	chr1	225501022	Silent	rs368744442	T550T	0.2
UCEC	chr1	225507950	Splice_Site	NA	X513_splice	0.38
UCEC	chr1	225497221	3'UTR	novel		0.21
UCEC	chr1	225495575	3'UTR	novel		0.38
UCEC	chr1	225494841	3'UTR	novel		0.59
UCEC	chr1	225497609	3'UTR	novel		0.31
UCEC	chr1	225497758	3'UTR	novel		0.25
UCEC	chr1	225514622	Missense_Mutation	rs143052362	G398R	0.37
UCEC	chr1	225496567	3'UTR	novel		0.59
UCEC	chr1	225505045	Missense_Mutation	novel	S516Y	0.35
UCEC	chr1	225487153	3'UTR	novel		0.5
UCEC	chr1	225494849	3'UTR	novel		0.16
UCEC	chr1	225496709	3'UTR	novel		0.53
UCEC	chr1	225497524	3'UTR	novel		0.41
UCEC	chr1	225519375	Missense_Mutation	NA	R209C	0.3
UCEC	chr1	225495723	3'UTR	novel		0.5
UCEC	chr1	225496816	3'UTR	novel		0.26
UCEC	chr1	225497540	3'UTR	rs766745912		0.34
UCEC	chr1	225519528	Missense_Mutation	rs535035689	R158W	0.06
UCEC	chr1	225512942	Silent	rs771348565	G431G	0.22
UCEC	chr1	225496825	3'UTR	novel		0.33
UCEC	chr1	225517215	Silent	rs765387144	A298A	0.27
UCEC	chr1	225494849	3'UTR	novel		0.44
UCEC	chr1	225555016	Nonsense_Mutation	novel	W80*	0.39
UCEC	chr1	225567337	Missense_Mutation	novel	G28D	0.52
UCEC	chr1	225513007	Missense_Mutation	novel	T410A	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.076	0.033566
DLBC	DEL	0.125	0.0017831
GBM	DEL	0.0537	0.00056261
KIRC	DEL	0.0663	0.018371
LGG	DEL	0.0331	0.11599
PCPG	DEL	0.0802	0.12617
PRAD	DEL	0.0671	0.00015401
READ	AMP	0.2545	0.14328
SARC	DEL	0.2996	2.6086e-08
TGCT	DEL	0.0333	0.16985
THYM	AMP	0.1789	0.24554
UCEC	AMP	0.3859	2.3921e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.013	Kaplan-Meier Survival Analysis
STAD	0.042	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.0036	Kaplan-Meier Survival Analysis
UCS	0.023	Kaplan-Meier Survival Analysis
KIRP	0.00056	Kaplan-Meier Survival Analysis
PAAD	0.01	Kaplan-Meier Survival Analysis
KICH	0.0016	Kaplan-Meier Survival Analysis
UCEC	0.048	Kaplan-Meier Survival Analysis
GBM	0.00037	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000154380 (Gene tree)
Gene ID: 55740
Gene Symbol: ENAH
Alias: FLJ10773|NDPP1|MENA
Full Name: ENAH actin regulator
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 174,845 bases
Position: chr1:225,486,832-225,661,676
Accession: 18271
RBP type: non-canonical RBP
Summary: This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497899	ENAH-207	807	-	ENSP00000489106	242 (aa)	-	A0A0U1RQP7
ENST00000635051	ENAH-209	3308	XM_017001747	ENSP00000489607	802 (aa)	XP_016857236	A0A0U1RRM6
ENST00000366844	ENAH-204	13168	XM_011544229	ENSP00000355809	591 (aa)	XP_011542531	Q8N8S7
ENST00000366843	ENAH-203	2758	XM_017001749	ENSP00000355808	570 (aa)	XP_016857238	Q8N8S7
ENST00000498108	ENAH-208	713	-	-	- (aa)	-	-
ENST00000391874	ENAH-205	888	-	-	- (aa)	-	-
ENST00000284563	ENAH-201	665	-	ENSP00000284563	213 (aa)	-	A0A075B6E5
ENST00000483952	ENAH-206	578	-	-	- (aa)	-	-
ENST00000358675	ENAH-202	3655	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000154380's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04360	Axon guidance	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000154380	Blood Pressure	6.0605644E-005	-
ENSG00000154380	Blood Pressure	9.3171405E-005	-
ENSG00000154380	Platelet Function Tests	3.4513424E-006	-
ENSG00000154380	Platelet Function Tests	3.1096995E-006	-
ENSG00000154380	Platelet Function Tests	3.4513424E-006	-
ENSG00000154380	Platelet Function Tests	5.9172582E-006	-
ENSG00000154380	Platelet Function Tests	1.0969800E-005	-
ENSG00000154380	Platelet Function Tests	2.8308856E-006	-
ENSG00000154380	Platelet Function Tests	5.4602214E-006	-
ENSG00000154380	Platelet Function Tests	3.4513424E-006	-
ENSG00000154380	Platelet Function Tests	3.5337878E-006	-
ENSG00000154380	Platelet Function Tests	3.4513424E-006	-
ENSG00000154380	Platelet Function Tests	3.1096995E-006	-
ENSG00000154380	Platelet Function Tests	2.9084243E-006	-
ENSG00000154380	Platelet Function Tests	3.1096995E-006	-
ENSG00000154380	Platelet Function Tests	3.1096995E-006	-
ENSG00000154380	Autistic Disorder	3.6109000E-005	-
ENSG00000154380	Autistic Disorder	1.3036000E-005	-
ENSG00000154380	Autistic Disorder	2.8186000E-005	-
ENSG00000154380	Autistic Disorder	3.0195000E-005	-
ENSG00000154380	Autistic Disorder	2.2006000E-005	-
ENSG00000154380	Autistic Disorder	1.1475000E-005	-
ENSG00000154380	Autistic Disorder	5.6826000E-006	-
ENSG00000154380	Child Development Disorders, Pervasive	1.4899100E-005	-
ENSG00000154380	Child Development Disorders, Pervasive	1.0125500E-005	-
ENSG00000154380	Child Development Disorders, Pervasive	1.2083100E-005	-
ENSG00000154380	Neuroticism	2E-8	27067015

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000154380	rs17502858	1	225593528	A	Neuroticism	29942085	z score increase	5.468	EFO_0007660

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000154380's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	16979624.21044950.21278383.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	-	IDA	Component
GO:0007411	axon guidance	-	TAS	Process
GO:0017124	SH3 domain binding	-	IEA	Function
GO:0030027	lamellipodium	-	IEA	Component
GO:0030054	cell junction	-	IDA	Component
GO:0030175	filopodium	-	IEA	Component
GO:0045202	synapse	-	IEA	Component
GO:0050699	WW domain binding	17686488.	IPI	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.