EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24166504	Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration.	Oncogene	2014 Jul 31	De Saedeleer CJ	doi: 10.1038/onc.2013.454
27240355	Mast Cell Tryptase Contributes to Pancreatic Cancer Growth through Promoting Angiogenesis via Activation of Angiopoietin-1.	Int J Mol Sci	2016 May 27	Guo X	doi: 10.3390/ijms17060834.
28260082	Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism.	Oncol Rep	2017 Apr	Shan T	doi: 10.3892/or.2017.5479
29248133	Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.	Semin Oncol	2017 Jun	Mikkilineni L	doi: 10.1053/j.seminoncol.2017.10.003
29066459	Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype.	EMBO Rep	2017 Dec	Silva LS	doi: 10.15252/embr.201744154
28235486	MACC1 mediates chemotherapy sensitivity of 5-FU and cisplatin via regulating MCT1 expression in gastric cancer.	Biochem Biophys Res Commun	2017 Apr 8	Wang C	doi: 10.1016/j.bbrc.2017.02.096
16136905	[The effect of monocarboxylate transporter gene on the regulation of pHi and growth character in cancer cells].	Zhonghua Jie He He Hu Xi Za Zhi	2001 Nov	Huang G	-
12479094	[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells].	Ai Zheng	2002 Jul	Zhang GZ	-
25755717	RNA interference targeting CD147 inhibits the proliferation, invasiveness, and metastatic activity of thyroid carcinoma cells by down-regulating glycolysis.	Int J Clin Exp Pathol	2015 Jan 1	Huang P	-
25456395	Expression of lactate/H symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses.	Hum Pathol	2015 Jan	Kim Y	doi: 10.1016/j.humpath.2014.09.013
24013424	CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.	Cell Cycle	2013 Oct 1	Walters DK	doi: 10.4161/cc.26193
26944480	Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism.	Biochim Biophys Acta	2016 Oct	Counillon L	doi: 10.1016/j.bbamcr.2016.02.018
28762551	Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk.	Mol Carcinog	2017 Dec	Miranda-Gonalves V	doi: 10.1002/mc.22707
27127175	Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity.	Oncotarget	2016 May 31	Gray AL	doi: 10.18632/oncotarget.9016.
26615136	Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer.	Semin Oncol	2015 Dec	Johnson JM	doi: 10.1053/j.seminoncol.2015.09.025
29775610	Monocarboxylate transporters in breast cancer and adipose tissue are novel biomarkers and potential therapeutic targets.	Biochem Biophys Res Commun	2018 Jul 2	Li Z	doi: 10.1016/j.bbrc.2018.05.091
26045776	MCT1 promotes the cisplatin-resistance by antagonizing Fas in epithelial ovarian cancer.	Int J Clin Exp Pathol	2015 Mar 1	Yan C	-
23574725	Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.	Cell Cycle	2013 May 1	Curry JM	doi: 10.4161/cc.24092
21306479	Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells.	Cancer Sci	2011 May	Izumi H	doi: 10.1111/j.1349-7006.2011.01908.x
26876179	MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.	Cell Rep	2016 Feb 23	Hong CS	doi: 10.1016/j.celrep.2016.01.057
26779534	Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis.	Biomed Res Int	2015	Bovenzi CD	doi: 10.1155/2015/242437
17182800	Monocarboxylate transporter 1 mediates DL-2-Hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers.	J Nutr	2007 Jan	Mart??n-Venegas R	-
25957999	Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells.	BMC Cancer	2015 May 10	Kershaw S	doi: 10.1186/s12885-015-1382-y.
24277449	Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.	Clin Cancer Res	2014 Feb 15	Pola??ski R	doi: 10.1158/1078-0432.CCR-13-2270
27957817	Monocarboxylate Transporter-1 Mediates the Protective Effects of Neutral-pH Bicarbonate/Lactate-Buffered Peritoneal Dialysis Fluid on Cell Viability and Apoptosis.	Ther Apher Dial	2017 Feb	Kuma A	doi: 10.1111/1744-9987.12476
28846107	Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells.	Oncogene	2018 Jan 4	Diehl K	doi: 10.1038/onc.2017.299
29809145	A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells.	Elife	2018 May 29	Noor SI	doi: 10.7554/eLife.35176.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	112917468	Missense_Mutation	NA	R313L	0.16
BLCA	chr1	112923706	Intron	novel		0.22
BLCA	chr1	112913963	Silent	NA	V477V	0.43
BLCA	chr1	112917328	Missense_Mutation	novel	A360T	0.37
BLCA	chr1	112923730	Intron	novel		0.13
BLCA	chr1	112924027	Intron	novel		0.15
BLCA	chr1	112917884	Nonsense_Mutation	NA	W174*	0.21
BLCA	chr1	112923487	Intron	novel		0.22
BLCA	chr1	112917296	Silent	NA	L370L	0.06
BLCA	chr1	112922111	Silent	NA	V80V	0.08
BLCA	chr1	112914001	Nonsense_Mutation	novel	E465*	0.2
BLCA	chr1	112924312	Intron	novel		0.29
BLCA	chr1	112913978	Silent	novel	G472G	0.25
BRCA	chr1	112956669	5'Flank	novel		0.34
BRCA	chr1	112923460	Intron	novel		0.13
BRCA	chr1	112914144	Missense_Mutation	rs746931470	G417E	0.3
BRCA	chr1	112917414	Missense_Mutation	novel	Y331C	0.09
BRCA	chr1	112917399	Missense_Mutation	NA	S336F	0.29
BRCA	chr1	112918004	Missense_Mutation	novel	M134I	0.45
BRCA	chr1	112922095	Missense_Mutation	rs759149434	R86C	0.13
BRCA	chr1	112923759	Intron	novel		0.18
BRCA	chr1	112917539	Missense_Mutation	NA	K289N	0.25
BRCA	chr1	112929228	Missense_Mutation	NA	F27L	0.43
BRCA	chr1	112914109	Missense_Mutation	rs151166713	V429I	0.49
BRCA	chr1	112923593	Intron	novel		0.29
BRCA	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.19
CESC	chr1	112913497	3'UTR	novel		0.39
CESC	chr1	112923613	Intron	novel		0.23
CESC	chr1	112914029	Silent	rs142145546	N455N	0.33
CESC	chr1	112913895	Missense_Mutation	novel	V500G	0.17
CESC	chr1	112917929	Frame_Shift_Del	novel	*F157Lfs20**	0.24
COAD	chr1	112917841	Missense_Mutation	NA	C189G	0.37
COAD	chr1	112924075	Intron	novel		0.35
COAD	chr1	112917423	Missense_Mutation	rs774823539	R328Q	0.26
COAD	chr1	112917898	Missense_Mutation	NA	G170C	0.43
COAD	chr1	112917581	Frame_Shift_Del	rs150151185	*F275Lfs37**	0.39
COAD	chr1	112913943	Missense_Mutation	rs767509828	P484L	0.37
COAD	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.46
COAD	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.35
COAD	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.73
COAD	chr1	112917876	Missense_Mutation	NA	S177I	0.13
COAD	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.29
COAD	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.23
COAD	chr1	112923926	Intron	novel		0.32
COAD	chr1	112914110	Silent	rs774103196	V428V	0.1
COAD	chr1	112922103	Missense_Mutation	NA	Y83C	0.21
COAD	chr1	112929187	Missense_Mutation	novel	T41N	0.13
COAD	chr1	112917405	Missense_Mutation	rs763573918	A334V	0.28
COAD	chr1	112917129	Intron	novel		0.3
COAD	chr1	112917156	Intron	novel		0.19
COAD	chr1	112929276	Silent	NA	Y11Y	0.4
COAD	chr1	112917912	Missense_Mutation	novel	N165S	0.05
DLBC	chr1	112917397	Missense_Mutation	rs746530125	V337I	0.27
ESCA	chr1	112917705	Missense_Mutation	novel	I234T	0.34
ESCA	chr1	112929142	Missense_Mutation	novel	S56T	0.18
ESCA	chr1	112917579	Missense_Mutation	novel	G276E	0.43
GBM	chr1	112923686	Intron	novel		0.25
GBM	chr1	112917876	Missense_Mutation	NA	S177N	0.1
GBM	chr1	112929140	Missense_Mutation	rs571088514	E57K	0.46
GBM	chr1	112923975	Intron	novel		0.35
HNSC	chr1	112913858	3'UTR	novel		0.08
HNSC	chr1	112913702	3'UTR	novel		0.44
HNSC	chr1	112917265	Missense_Mutation	novel	L381F	0.38
HNSC	chr1	112924040	Intron	novel		0.13
HNSC	chr1	112917794	Silent	rs763951746	K204K	0.35
HNSC	chr1	112917423	Missense_Mutation	rs774823539	R328Q	0.24
KIRC	chr1	112917656	Frame_Shift_Ins	novel	*N250Kfs36**	0.16
KIRC	chr1	112914149	Missense_Mutation	NA	M415I	0.05
KIRP	chr1	112917655	Nonsense_Mutation	NA	Q251*	0.2
KIRP	chr1	112923908	Intron	novel		0.26
LAML	chr1	112923638	Intron	novel		0.05
LAML	chr1	112923582	Intron	novel		0.14
LGG	chr1	112917968	Silent	novel	A146A	0.49
LIHC	chr1	112924085	Intron	novel		0.45
LIHC	chr1	112922109	Missense_Mutation	novel	N81I	0.17
LUAD	chr1	112923678	Intron	novel		0.32
LUAD	chr1	112924003	Intron	novel		0.25
LUAD	chr1	112914132	Frame_Shift_Del	novel	*Y421Hfs41**	0.07
LUAD	chr1	112917856	Missense_Mutation	rs776906225	L184V	0.12
LUAD	chr1	112917555	Missense_Mutation	NA	L284P	0.18
LUAD	chr1	112922048	Silent	NA	I101I	0.46
LUAD	chr1	112917300	Missense_Mutation	NA	W369L	0.36
LUAD	chr1	112923682	Intron	novel		0.16
LUAD	chr1	112917114	Intron	novel		0.44
LUAD	chr1	112913946	Missense_Mutation	NA	S483C	0.15
LUAD	chr1	112929095	Missense_Mutation	NA	G72R	0.14
LUAD	chr1	112929104	Missense_Mutation	NA	M69L	0.22
LUAD	chr1	112913931	Frame_Shift_Del	novel	*D488Hfs18**	0.25
LUAD	chr1	112924126	Intron	NA		0.76
LUAD	chr1	112917824	Silent	NA	L194L	0.52
LUAD	chr1	112914080	Silent	NA	F438F	0.21
LUSC	chr1	112917197	Silent	novel	L403L	0.28
LUSC	chr1	112917724	Missense_Mutation	novel	D228N	0.07
LUSC	chr1	112929281	Nonsense_Mutation	novel	G10*	0.62
LUSC	chr1	112917256	Missense_Mutation	novel	P384S	0.33
LUSC	chr1	112917325	Nonsense_Mutation	novel	G361*	0.34
LUSC	chr1	112923504	Intron	novel		0.33
LUSC	chr1	112929119	Missense_Mutation	rs761211321	I64V	0.29
LUSC	chr1	112918023	Missense_Mutation	NA	L128W	0.23
LUSC	chr1	112913852	3'UTR	novel		0.12
LUSC	chr1	112913866	3'UTR	novel		0.25
LUSC	chr1	112929353	Splice_Site	novel		0.22
OV	chr1	112917657	Missense_Mutation	novel	N250S	0.1
OV	chr1	112917993	Missense_Mutation	novel	Y138F	0.26
OV	chr1	112914069	Missense_Mutation	NA	G442V	0.13
OV	chr1	112956604	5'Flank	novel		0.3
OV	chr1	112917704	Silent	novel	I234I	0.03
OV	chr1	112924008	Intron	NA		0.44
OV	chr1	112917499	Missense_Mutation	novel	S303A	0.08
PAAD	chr1	112929219	Silent	rs768373027	I30I	0.06
READ	chr1	112917812	Silent	rs755634416	I198I	0.08
READ	chr1	112917882	Missense_Mutation	novel	R175K	0.39
READ	chr1	112924079	Intron	NA		0.37
READ	chr1	112923963	Intron	novel		0.16
READ	chr1	112914110	Silent	rs774103196	V428V	0.41
READ	chr1	112917423	Missense_Mutation	rs774823539	R328Q	0.37
SARC	chr1	112924261	Intron	novel		0.79
SKCM	chr1	112921995	Missense_Mutation	novel	I119N	0.22
SKCM	chr1	112917649	Silent	novel	L253L	0.17
SKCM	chr1	112917502	Missense_Mutation	NA	L302F	0.15
SKCM	chr1	112917943	Missense_Mutation	NA	P155S	0.25
SKCM	chr1	112923903	Intron	novel		0.69
SKCM	chr1	112917405	Missense_Mutation	rs763573918	A334V	0.48
SKCM	chr1	112917639	Missense_Mutation	NA	T256I	0.12
SKCM	chr1	112923634	Intron	novel		0.19
SKCM	chr1	112929223	Missense_Mutation	NA	S29F	0.79
SKCM	chr1	112917204	Missense_Mutation	NA	P401L	0.22
SKCM	chr1	112923669	Intron	novel		0.7
STAD	chr1	112922072	Silent	novel	G93G	0.24
STAD	chr1	112924126	Intron	NA		0.29
STAD	chr1	112917424	Nonsense_Mutation	rs606231310	R328*	0.36
STAD	chr1	112914159	Missense_Mutation	NA	L412H	0.15
STAD	chr1	112917405	Missense_Mutation	rs763573918	A334V	0.31
STAD	chr1	112923703	Intron	novel		0.16
STAD	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.26
STAD	chr1	112914072	Missense_Mutation	NA	M441T	0.12
STAD	chr1	112923867	Intron	novel		0.54
STAD	chr1	112924093	Intron	novel		0.12
STAD	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.26
STAD	chr1	112929267	Frame_Shift_Ins	rs606231309	*D15Rfs34**	0.21
STAD	chr1	112922027	Silent	rs147057122	T108T	0.51
THYM	chr1	112913773	3'UTR	novel		0.45
THYM	chr1	112929254	Missense_Mutation	novel	G19C	0.45
UCEC	chr1	112923900	Intron	novel		0.37
UCEC	chr1	112924264	Intron	novel		0.4
UCEC	chr1	112913968	Nonsense_Mutation	NA	E476*	0.33
UCEC	chr1	112917423	Missense_Mutation	rs774823539	R328Q	0.39
UCEC	chr1	112913470	3'UTR	novel		0.16
UCEC	chr1	112917423	Missense_Mutation	rs774823539	R328Q	0.28
UCEC	chr1	112917746	Silent	novel	S220S	0.35
UCEC	chr1	112917110	Intron	novel		0.43
UCEC	chr1	112917338	Silent	NA	F356F	0.48
UCEC	chr1	112917920	Silent	rs17852383	A162A	0.14
UCEC	chr1	112922010	Missense_Mutation	novel	V114A	0.06
UCEC	chr1	112923547	Intron	novel		0.28
UCEC	chr1	112917581	Frame_Shift_Del	rs150151185	*F275Lfs37**	0.64
UCEC	chr1	112924017	Intron	novel		0.17
UCEC	chr1	112924013	Intron	novel		0.21
UCEC	chr1	112924150	Intron	novel		0.11
UCEC	chr1	112924142	Intron	novel		0.08
UCEC	chr1	112924272	Intron	novel		0.26
UCEC	chr1	112913538	3'UTR	rs762874265		0.32
UCEC	chr1	112917002	Intron	novel		0.32
UCEC	chr1	112917679	Nonsense_Mutation	NA	R243*	0.31
UCEC	chr1	112929140	Missense_Mutation	rs571088514	E57K	0.46
UCEC	chr1	112914071	Missense_Mutation	novel	M441I	0.38
UCEC	chr1	112917326	Silent	novel	A360A	0.32
UCEC	chr1	112917650	Silent	novel	F252F	0.2
UCEC	chr1	112917808	Missense_Mutation	novel	P200S	0.43
UCEC	chr1	112929158	Missense_Mutation	novel	F51V	0.45
UCEC	chr1	112956967	5'Flank	novel		0.42
UCEC	chr1	112917242	Silent	NA	S388S	0.37
UCEC	chr1	112917305	Silent	rs150299630	F367F	0.34
UCEC	chr1	112917561	Missense_Mutation	novel	V282A	0.42
UCEC	chr1	112923522	Intron	novel		0.37
UCEC	chr1	112916940	Intron	novel		0.19
UCEC	chr1	112924322	Intron	novel		0.06
UCEC	chr1	112917644	Silent	rs753981488	D254D	0.18
UCEC	chr1	112924074	Intron	novel		0.41
UCEC	chr1	112923523	Intron	novel		0.43
UCEC	chr1	112917979	Nonsense_Mutation	rs577209023	R143*	0.3
UCEC	chr1	112917423	Missense_Mutation	rs774823539	R328Q	0.44
UCEC	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.46
UCEC	chr1	112917026	Intron	novel		0.27
UCEC	chr1	112922130	Missense_Mutation	novel	P74H	0.29
UCEC	chr1	112913739	3'UTR	novel		0.18
UCEC	chr1	112917305	Silent	rs150299630	F367F	0.51
UCEC	chr1	112929267	Frame_Shift_Ins	rs606231309	*D15Rfs34**	0.45
UCEC	chr1	112917074	Intron	novel		0.2
UCEC	chr1	112917363	Missense_Mutation	novel	P348H	0.24
UCEC	chr1	112924024	Intron	novel		0.51
UCEC	chr1	112914029	Silent	rs142145546	N455N	0.32
UCEC	chr1	112929268	Frame_Shift_Del	NA	*P14Qfs10**	0.5
UCEC	chr1	112923439	Intron	novel		0.15
UCEC	chr1	112924028	Intron	novel		0.32
UCEC	chr1	112924191	Intron	novel		0.1
UCEC	chr1	112917410	Missense_Mutation	NA	F332L	0.28
UCEC	chr1	112917402	Missense_Mutation	novel	A335D	0.05
UCEC	chr1	112917957	Missense_Mutation	novel	A150V	0.41
UCEC	chr1	112929321	5'UTR	rs200710280		0.21
UCEC	chr1	112922050	Missense_Mutation	NA	I101V	0.15
UCEC	chr1	112923559	Intron	novel		0.33
UCEC	chr1	112923804	Intron	novel		0.13
UCEC	chr1	112924052	Intron	novel		0.43
UCEC	chr1	112914109	Missense_Mutation	rs151166713	V429I	0.46
UCEC	chr1	112917709	Missense_Mutation	NA	L233I	0.35
UCEC	chr1	112917865	Missense_Mutation	novel	L181I	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2306	5.7821e-10
CESC	DEL	0.0983	0.01281
COAD	DEL	0.2217	0.00038973
DLBC	DEL	0.1042	0.0017831
HNSC	DEL	0.2069	7.836e-19
LUAD	DEL	0.2345	2.5961e-13
MESO	DEL	0.3563	5.9874e-12
READ	DEL	0.2667	0.013822
SKCM	DEL	0.1717	9.7877e-07
STAD	DEL	0.161	0.0040659
TGCT	AMP	0.1933	0.088103

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0062	Kaplan-Meier Survival Analysis
KIRC	0.01	Kaplan-Meier Survival Analysis
SARC	0.00021	Kaplan-Meier Survival Analysis
ACC	0.00019	Kaplan-Meier Survival Analysis
SKCM	0.0071	Kaplan-Meier Survival Analysis
KIRP	0.0084	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.0018	Kaplan-Meier Survival Analysis
CESC	0.023	Kaplan-Meier Survival Analysis
READ	0.0069	Kaplan-Meier Survival Analysis
KICH	0.00053	Kaplan-Meier Survival Analysis
UCEC	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.019	Kaplan-Meier Survival Analysis
LGG	0.00017	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0081	Kaplan-Meier Survival Analysis
OV	0.034	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000155380 (Gene tree)
Gene ID: 6566
Gene Symbol: SLC16A1
Alias: MCT|MCT1
Full Name: solute carrier family 16 member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 45,167 bases
Position: chr1:112,911,847-112,957,013
Accession: 10922
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000478835	SLC16A1-205	452	-	-	- (aa)	-	-
ENST00000458229	SLC16A1-204	2201	-	ENSP00000416167	456 (aa)	-	Q5T8R5
ENST00000538576	SLC16A1-207	4374	-	ENSP00000441065	500 (aa)	-	P53985
ENST00000443580	SLC16A1-203	1099	-	ENSP00000399104	296 (aa)	-	Q5T8R3
ENST00000429288	SLC16A1-202	865	-	ENSP00000397106	215 (aa)	-	Q5T8R4
ENST00000369626	SLC16A1-201	3910	-	ENSP00000358640	500 (aa)	-	P53985
ENST00000481750	SLC16A1-206	430	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000155380's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000155380	Child Development Disorders, Pervasive	4.8080300E-005	-
ENSG00000155380	Child Development Disorders, Pervasive	2.5393000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000155380	rs55992320	1	112950793	?	Macular thickness	30535121	[0.48-0.8] unit increase	0.6397	EFO_0008375

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000155380's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005813	centrosome	23816619.	IDA	Component
GO:0005886	plasma membrane	24390345.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005887	integral component of plasma membrane	21873635.	IBA	Component
GO:0005887	integral component of plasma membrane	15505343.	IDA	Component
GO:0005887	integral component of plasma membrane	-	ISS	Component
GO:0006090	pyruvate metabolic process	-	TAS	Process
GO:0006629	lipid metabolic process	-	IEA	Process
GO:0007098	centrosome cycle	23816619.	IMP	Process
GO:0008028	monocarboxylic acid transmembrane transporter activity	21873635.	IBA	Function
GO:0015129	lactate transmembrane transporter activity	-	IEA	Function
GO:0015130	mevalonate transmembrane transporter activity	1429658.	TAS	Function
GO:0015293	symporter activity	-	IEA	Function
GO:0015718	monocarboxylic acid transport	21873635.	IBA	Process
GO:0015728	mevalonate transport	1429658.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	1429658.	TAS	Component
GO:0030054	cell junction	-	IDA	Component
GO:0032094	response to food	-	IEA	Process
GO:0035879	plasma membrane lactate transport	-	ISS	Process
GO:0042593	glucose homeostasis	-	IEA	Process
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045202	synapse	-	IEA	Component
GO:0050796	regulation of insulin secretion	-	IEA	Process
GO:0050900	leukocyte migration	-	TAS	Process
GO:0051780	behavioral response to nutrient	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071407	cellular response to organic cyclic compound	-	IEA	Process
GO:0097159	organic cyclic compound binding	-	IEA	Function

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.