EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26561469The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis.Tumour Biol2016 AprHajjari Mdoi: 10.1007/s13277-015-4250-0
21030981PHF6 mutations in adult acute myeloid leukemia.Leukemia2011 JanVan Vlierberghe Pdoi: 10.1038/leu.2010.247
24674452Detection of an activated JAK3 variant and a Xq26.3 microdeletion causing loss of PHF6 and miR-424 expression in myelodysplastic syndromes by combined targeted next generation sequencing and SNP array analysis.Pathol Res Pract2014 JunKunze Kdoi: 10.1016/j.prp.2014.02.006
23229552PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis.J Biol Chem2013 Feb 1Wang Jdoi: 10.1074/jbc.M112.414839
20228800PHF6 mutations in T-cell acute lymphoblastic leukemia.Nat Genet2010 AprVan Vlierberghe Pdoi: 10.1038/ng.542
24895337MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia.Haematologica2014 AugMets Edoi: 10.3324/haematol.2013.099515
20806366T-cell acute lymphoblastic leukemia in association with Brjeson-Forssman-Lehmann syndrome due to a mutation in PHF6.Pediatr Blood Cancer2010 OctChao MMdoi: 10.1002/pbc.22574.
25737277A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.Genes Dev2015 Mar 1Meacham CEdoi: 10.1101/gad.254151.114.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchrX134378068Nonsense_MutationNAE68*0.3
BLCAchrX134425232Missense_MutationnovelE334Q0.24
BLCAchrX1344253453'UTRrs7504649380.96
BLCAchrX134377739Missense_MutationnovelA41G0.4
BLCAchrX134393508Missense_MutationnovelS83F0.4
BLCAchrX134415076Missense_MutationNAD264H0.38
BLCAchrX134425236Missense_MutationnovelR335K0.4
BLCAchrX134377756Splice_SiteNAX46_splice0.49
BRCAchrX134413493Missense_MutationNAD141N0.45
BRCAchrX134425214Missense_MutationNAN328Y0.16
BRCAchrX134417387Intronrs7794143280.22
BRCAchrX1344254523'UTRnovel0.08
CESCchrX1343775985'UTRnovel0.2
CESCchrX134417418IntronNA0.42
CESCchrX134415106Nonsense_MutationNAR274*0.1
CESCchrX1344273583'UTRnovel0.32
CESCchrX1344262573'UTRnovel0.12
CESCchrX134417290Missense_MutationNAR319Q0.46
CESCchrX1344287183'UTRnovel0.09
CESCchrX1344274663'UTRnovel0.15
CESCchrX1344285143'UTRnovel0.36
CHOLchrX1344260423'UTRnovel0.26
COADchrX134377736Missense_MutationnovelA40V0.46
COADchrX1344254163'UTRnovel0.33
COADchrX134413609SilentNAT179T0.33
COADchrX1344254163'UTRnovel0.4
COADchrX1344253903'UTRnovel0.26
COADchrX134377661Missense_MutationnovelR15H0.38
COADchrX134415225Intronrs2014549230.07
ESCAchrX1344278323'UTRnovel0.43
ESCAchrX1344277283'UTRnovel0.13
ESCAchrX1344260733'UTRnovel0.15
ESCAchrX1344261943'UTRnovel0.38
GBMchrX134417300Nonsense_MutationnovelY322*0.27
HNSCchrX134415070Missense_MutationnovelD262N0.41
HNSCchrX134393563SilentnovelR101R0.92
KIRCchrX134417209Missense_MutationNAC292S0.09
KIRCchrX1343775835'UTRnovel0.08
KIRCchrX1343776165'UTRnovel0.53
LAMLchrX134425208Missense_MutationnovelC326R0.08
LAMLchrX134413822Splice_SiteNAX196_splice0.53
LAMLchrX134393949Nonsense_MutationNAE139*0.72
LAMLchrX134377682Frame_Shift_InsNAN23Kfs*20.83
LGGchrX134393944Missense_MutationNAN137S0.06
LGGchrX134415225Intronrs2014549230.38
LGGchrX134377620Translation_Start_SiteNAM1?0.29
LIHCchrX134393929Missense_Mutationrs756384013K132R0.5
LUADchrX134425204SilentNAL324L0.94
LUADchrX134413935Missense_MutationnovelA233G0.44
LUADchrX134415236Intronnovel0.86
LUADchrX134413637Nonsense_MutationnovelE189*0.32
LUADchrX134417290Missense_MutationNAR319L0.21
LUADchrX134393927Missense_MutationNAH131Q0.19
LUSCchrX134417281Missense_MutationnovelN316I0.13
LUSCchrX134393562Missense_MutationnovelR101K0.21
LUSCchrX134415028Missense_MutationNAG248C0.11
LUSCchrX134393581SilentnovelC107C0.1
LUSCchrX134415070Missense_MutationnovelD262H0.11
OVchrX1344253463'UTRnovel0.03
OVchrX134415015Splice_SiteNAX244_splice0.28
PAADchrX134415226Intronrs3695812150.07
READchrX1344254163'UTRnovel0.19
SARCchrX134393590Missense_MutationnovelH110Q0.45
SARCchrX1344276343'UTRnovel0.1
SKCMchrX134413563Missense_MutationNAK164R0.83
SKCMchrX134417394Intronnovel0.44
SKCMchrX134417222SilentNAA296A0.76
SKCMchrX134417237SilentNAY301Y1
STADchrX1344254163'UTRnovel0.38
STADchrX134415123Splice_Regionnovel0.13
STADchrX134417289Nonsense_MutationNAR319*0.1
STADchrX134413584Missense_MutationNAN171I0.48
THCAchrX134393537Missense_MutationNAG93C0.08
THCAchrX134417318Intronnovel0.06
THYMchrX1344260733'UTRnovel0.33
UCECchrX134413824Missense_MutationNAR196K0.35
UCECchrX134415211Intronnovel0.05
UCECchrX134417231Missense_MutationNAK299N0.13
UCECchrX134413528Missense_MutationnovelE152D0.31
UCECchrX134417227Missense_MutationnovelV298A0.21
UCECchrX1344286203'UTRnovel0.41
UCECchrX134393930Missense_MutationNAK132N0.36
UCECchrX134417357Intronnovel0.49
UCECchrX1344284803'UTRnovel0.19
UCECchrX134393949Missense_Mutationrs770811341E139K0.52
UCECchrX1344276243'UTRnovel0.19
UCECchrX1344278643'UTRnovel0.45
UCECchrX1344260383'UTRnovel0.6
UCECchrX134393508Missense_MutationnovelS83F0.25
UCECchrX1344259433'UTRnovel0.29
UCECchrX1344286863'UTRnovel0.12
UCECchrX1344267723'UTRnovel0.46
UCECchrX1344260613'UTRnovel0.2
UCECchrX134413647Missense_MutationnovelS192N0.06
UCECchrX134415072Missense_MutationnovelD262E0.09
UCECchrX134417288SilentNAS318S0.2
UCECchrX1344273473'UTRnovel0.48
UCECchrX134393621Nonsense_MutationnovelQ121delinsPNSLAGFKIY*0.04
UCECchrX134393607Missense_Mutationrs267606359R116Q0.13
UCECchrX134377630Missense_MutationnovelV5I0.16
UCECchrX1344254193'UTRnovel0.15
UCECchrX134377622Nonsense_MutationNAS2*0.42
UCECchrX1344270713'UTRnovel0.15
UCECchrX134413888Frame_Shift_InsnovelG218Wfs*60.38
UCECchrX134415061Nonsense_MutationnovelE259*0.4
UCECchrX1344258193'UTRnovel0.42
UCECchrX1344268303'UTRnovel0.38
UCECchrX1344286083'UTRnovel0.33
UCECchrX1344272033'UTRnovel0.32
UCECchrX1344254163'UTRnovel0.21
UCECchrX1344277973'UTRnovel0.33
UCECchrX1344281753'UTRnovel0.38
UCECchrX1344282803'UTRnovel0.43
UCECchrX1344287493'UTRnovel0.24
UCECchrX1344281013'UTRnovel0.47
UCECchrX1344285243'UTRnovel0.5
UCECchrX1344254033'UTRnovel0.47
UCECchrX1344274603'UTRnovel0.37
UCECchrX1344286353'UTRnovel0.44
UCECchrX1344266843'UTRnovel0.57
UCECchrX1344274083'UTRnovel0.56
UCECchrX1344279233'UTRnovel0.41
UCECchrX1344281653'UTRnovel0.5
UCECchrX134415215Intronnovel0.35
UCECchrX134415225Intronrs2014549230.28
UCECchrX134413559Missense_Mutationrs199945885R163C0.41
UCECchrX134415116Missense_MutationnovelR277I0.3
UCECchrX1344254253'UTRnovel0.57
UCECchrX1344271363'UTRnovel0.26
UCECchrX1344286033'UTRnovel0.28
UCECchrX1344264593'UTRnovel0.43
UCECchrX134415072Frame_Shift_InsNAD264*0.27
UCECchrX134393908Splice_SitenovelX125_splice0.2
UCECchrX134378099Missense_Mutationrs767406620T78M0.43
UCECchrX1344283813'UTRnovel0.32
UCECchrX1344264313'UTRnovel0.37
UCECchrX134415225Intronrs2014549230.23
UCECchrX1344277363'UTRnovel0.22
UCECchrX1344270633'UTRnovel0.48
UCECchrX1344285563'UTRnovel0.37
UCECchrX1344279503'UTRnovel0.27
UCECchrX1344283633'UTRnovel0.21
UCECchrX1344285493'UTRnovel0.35
UCECchrX1344255313'UTRnovel0.5
UCECchrX1344265573'UTRnovel0.53
UCECchrX1344285953'UTRnovel0.38
UCECchrX134425271Nonsense_MutationnovelR347*0.04
UCECchrX134417298Missense_MutationnovelY322D0.57
UCECchrX134393537Missense_MutationnovelG93S0.06
UCECchrX134425247Missense_MutationnovelD339N0.05
UCECchrX1344273333'UTRnovel0.11
UCECchrX1344262463'UTRnovel0.36
UCECchrX1344267463'UTRnovel0.16
UCECchrX1344274913'UTRrs1498253330.53
UCECchrX1344285553'UTRnovel0.51
UCECchrX134393621Frame_Shift_InsnovelQ121Pfs*240.07
UCECchrX134417479Intronnovel0.33
UCECchrX1344260073'UTRnovel0.43
UCECchrX1344267733'UTRnovel0.15
UCECchrX134413639Missense_MutationNAE189D0.3
UCECchrX134413498SilentnovelL142L0.37
UCECchrX1344260923'UTRnovel0.34
UCECchrX1344276343'UTRnovel0.36
UCECchrX1344254473'UTRnovel0.32
UCECchrX1344281013'UTRnovel0.24
UCECchrX1344270103'UTRnovel0.35
UCECchrX1344278963'UTRnovel0.35
UCECchrX134417348Intronrs7567556470.19
UCECchrX134413571Missense_MutationnovelP167S0.37
UCECchrX1344275843'UTRnovel0.33
UCECchrX1344284013'UTRnovel0.36
UCECchrX1344253603'UTRnovel0.39
UCECchrX1344278283'UTRnovel0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.08330.24013
KIRCAMP0.03030.12739
READAMP0.13330.14805
TGCTDEL0.06670.08422
THCADEL00.21991
UCSDEL0.30360.063955

Survival Analysis
CancerP-value Q-value
KIRC0.0067

Kaplan-Meier Survival Analysis

SARC0.0032

Kaplan-Meier Survival Analysis

MESO0.044

Kaplan-Meier Survival Analysis

ACC0.001

Kaplan-Meier Survival Analysis

HNSC0.0073

Kaplan-Meier Survival Analysis

SKCM0.00031

Kaplan-Meier Survival Analysis

LUSC0.014

Kaplan-Meier Survival Analysis

BRCA0.014

Kaplan-Meier Survival Analysis

KIRP0.0024

Kaplan-Meier Survival Analysis

PAAD0.0017

Kaplan-Meier Survival Analysis

BLCA0.025

Kaplan-Meier Survival Analysis

UCEC0.0053

Kaplan-Meier Survival Analysis

GBM0.0008

Kaplan-Meier Survival Analysis

LIHC0.0012

Kaplan-Meier Survival Analysis

LGG0.011

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000156531 (Gene tree)
Gene ID
84295
Gene Symbol
PHF6
Alias
KIAA1823|MGC14797|CENP-31|BFLS|BORJ
Full Name
PHD finger protein 6
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
55,540 bases
Position
chrX:134,373,253-134,428,792
Accession
18145
RBP type
non-canonical RBP
Summary
This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by cognitive disability, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23229552PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis.J Biol Chem2013 Feb 1Wang Jdoi: 10.1074/jbc.M112.414839
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000332070PHF6-2014759-ENSP00000329097365 (aa)-Q8IWS0
ENST00000370799PHF6-2024186-ENSP00000359835324 (aa)-Q5JRC6
ENST00000625464PHF6-2054434-ENSP00000487420366 (aa)-A0A0D9SGE8
ENST00000370803PHF6-2044489-ENSP00000359839365 (aa)-Q8IWS0
ENST00000370800PHF6-2031150-ENSP00000359836312 (aa)-Q8IWS0
Gene Model
Click here to download ENSG00000156531's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000156531's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II24554700.IDAProcess
GO:0000777condensed chromosome kinetochore-IEAComponent
GO:0001227DNA-binding transcription repressor activity, RNA polymerase II-specific24554700.IDAFunction
GO:0001835blastocyst hatching-IEAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding22720776.IPIFunction
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm22720776.IDAComponent
GO:0005730nucleolus22720776.IDAComponent
GO:0015631tubulin binding22720776.IPIFunction
GO:0019899enzyme binding22720776.IPIFunction
GO:0042393histone binding22720776.IPIFunction
GO:0042826histone deacetylase binding22720776.IPIFunction
GO:0043021ribonucleoprotein complex binding22720776.IPIFunction
GO:0043565sequence-specific DNA binding24554700.IDAFunction
GO:0046872metal ion binding-IEAFunction
GO:0051219phosphoprotein binding22720776.IPIFunction
GO:0097110scaffold protein binding22720776.IPIFunction
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