EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23161539	The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.	J Biol Chem	2013 Jan 11	Shimamura S	doi: 10.1074/jbc.M112.386722
28786507	SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin.	J Cell Biochem	2018 Feb	Wang J	doi: 10.1002/jcb.26334
28387985	Clinicopathological significance of the microRNA-146a/WASP-family verprolin-homologous protein-2 axis in gastric cancer.	Cancer Sci	2017 Jul	Yao Q	doi: 10.1111/cas.13254
24778020	Down-regulation of WAVE2, WASP family verprolin-homologous protein 2, in gastric cancer indicates lymph node metastasis and cell migration.	Anticancer Res	2014 May	Jia S	-
23435376	MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2.	Cancer Lett	2013 Jul 10	Yao Q	doi: 10.1016/j.canlet.2013.02.031

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	27410171	Missense_Mutation	novel	A287V	0.26
BLCA	chr1	27418410	Missense_Mutation	novel	G93E	0.22
BLCA	chr1	27408323	Nonsense_Mutation	novel	E455*	0.16
BLCA	chr1	27409953	Missense_Mutation	novel	D360N	0.09
BLCA	chr1	27409979	Missense_Mutation	NA	S351L	0.19
BLCA	chr1	27418300	Missense_Mutation	NA	P130S	0.21
BLCA	chr1	27419011	Missense_Mutation	rs775407600	E70K	0.34
BLCA	chr1	27428877	Missense_Mutation	novel	T5M	0.19
BLCA	chr1	27419077	Missense_Mutation	NA	E48K	0.21
BRCA	chr1	27428933	Splice_Region	novel		0.34
BRCA	chr1	27405668	3'UTR	novel		0.21
BRCA	chr1	27419011	Missense_Mutation	NA	E70Q	0.22
BRCA	chr1	27418364	Missense_Mutation	NA	Q108H	0.15
BRCA	chr1	27412610	Missense_Mutation	NA	F262L	0.24
CESC	chr1	27416054	Missense_Mutation	NA	F156L	0.33
CESC	chr1	27406521	3'UTR	novel		0.25
CESC	chr1	27410062	Silent	novel	P323P	0.39
CESC	chr1	27405964	3'UTR	novel		0.22
CESC	chr1	27408263	Missense_Mutation	novel	R475C	0.27
CESC	chr1	27418421	Splice_Region	novel	V89V	0.29
CESC	chr1	27407276	3'UTR	novel		0.48
CHOL	chr1	27418296	Missense_Mutation	novel	P131H	0.06
COAD	chr1	27408259	Missense_Mutation	novel	R476H	0.27
COAD	chr1	27409998	Missense_Mutation	novel	G345W	0.3
COAD	chr1	27416029	Silent	novel	L165L	0.25
COAD	chr1	27409843	Silent	NA	P396P	0.17
COAD	chr1	27414917	Missense_Mutation	NA	K195T	0.2
COAD	chr1	27414889	Missense_Mutation	novel	E204D	0.07
COAD	chr1	27418956	Missense_Mutation	NA	E88G	0.3
COAD	chr1	27409885	Silent	novel	P382P	0.23
COAD	chr1	27418415	Silent	NA	L91L	0.18
DLBC	chr1	27428926	5'UTR	novel		0.45
ESCA	chr1	27405887	3'UTR	novel		0.17
ESCA	chr1	27405798	3'UTR	novel		0.14
ESCA	chr1	27416015	Missense_Mutation	novel	K169N	0.35
GBM	chr1	27410054	Missense_Mutation	rs762995655	P326L	0.24
GBM	chr1	27428766	Missense_Mutation	novel	S42N	0.06
HNSC	chr1	27409731	Missense_Mutation	novel	S434C	0.14
HNSC	chr1	27418324	Frame_Shift_Del	novel	*E122Kfs51**	0.17
HNSC	chr1	27428866	Missense_Mutation	rs151177492	E9K	0.48
HNSC	chr1	27418291	Missense_Mutation	novel	L133I	0.14
HNSC	chr1	27416081	Silent	rs200795125	L147L	0.18
KIRC	chr1	27428895	5'UTR	novel		0.33
KIRC	chr1	27410005	In_Frame_Ins	novel	F341_G342dup	0.21
KIRC	chr1	27412636	Missense_Mutation	NA	S254T	0.15
KIRC	chr1	27419063	Silent	NA	G52G	0.41
KIRP	chr1	27412685	Silent	NA	C237C	0.14
KIRP	chr1	27416063	Silent	novel	P153P	0.3
LGG	chr1	27409997	Missense_Mutation	rs780474007	G345E	0.14
LIHC	chr1	27408286	Missense_Mutation	NA	N467S	0.41
LIHC	chr1	27412675	Missense_Mutation	NA	V241M	0.37
LIHC	chr1	27412675	Missense_Mutation	NA	V241M	0.09
LUAD	chr1	27408281	Missense_Mutation	novel	V469M	0.1
LUAD	chr1	27416006	Missense_Mutation	NA	M172I	0.09
LUAD	chr1	27418968	Missense_Mutation	novel	P84L	0.22
LUAD	chr1	27408233	Missense_Mutation	novel	E485Q	0.15
LUSC	chr1	27408073	3'UTR	novel		0.25
OV	chr1	27412594	Missense_Mutation	NA	P268A	0.71
OV	chr1	27428876	Silent	rs764392418	T5T	0.12
PAAD	chr1	27408115	3'UTR	novel		0.21
PAAD	chr1	27414864	Missense_Mutation	novel	V213M	0.05
PRAD	chr1	27418330	Missense_Mutation	NA	V120L	0.41
PRAD	chr1	27416078	Frame_Shift_Del	novel	*K148Ifs10**	0.17
READ	chr1	27418327	Silent	NA	L121L	0.39
SARC	chr1	27407362	3'UTR	novel		0.33
SARC	chr1	27407363	3'UTR	novel		0.34
SKCM	chr1	27409848	Missense_Mutation	novel	P395S	0.27
SKCM	chr1	27409849	Silent	rs200541363	P394P	0.26
SKCM	chr1	27410048	Missense_Mutation	novel	P328L	0.26
SKCM	chr1	27409844	Missense_Mutation	novel	P396L	0.42
SKCM	chr1	27414923	Missense_Mutation	novel	P193L	0.07
SKCM	chr1	27414924	Missense_Mutation	novel	P193S	0.07
SKCM	chr1	27409699	Silent	NA	I444I	0.23
SKCM	chr1	27418332	Missense_Mutation	NA	P119L	0.27
SKCM	chr1	27409947	Missense_Mutation	NA	A362S	0.48
SKCM	chr1	27408186	3'UTR	novel		0.32
SKCM	chr1	27408154	3'UTR	novel		0.12
SKCM	chr1	27410141	Missense_Mutation	novel	P297L	0.12
SKCM	chr1	27410142	Missense_Mutation	novel	P297S	0.14
SKCM	chr1	27409866	Missense_Mutation	novel	G389R	0.46
SKCM	chr1	27409820	Missense_Mutation	NA	P404L	0.45
SKCM	chr1	27409957	Silent	NA	H358H	0.28
SKCM	chr1	27412608	Missense_Mutation	rs267598535	S263F	0.17
SKCM	chr1	27419035	Frame_Shift_Del	novel	*T60Lfs8**	0.33
SKCM	chr1	27410201	Missense_Mutation	NA	P277L	0.12
STAD	chr1	27409849	Silent	rs200541363	P394P	0.43
STAD	chr1	27416044	Missense_Mutation	NA	W160R	0.11
STAD	chr1	27419047	Missense_Mutation	NA	A58T	0.43
STAD	chr1	27428783	Silent	novel	V36V	0.17
STAD	chr1	27428877	Missense_Mutation	novel	T5M	0.21
STAD	chr1	27418390	Missense_Mutation	NA	F100I	0.2
STAD	chr1	27410197	Silent	novel	V278V	0.24
STAD	chr1	27418372	Nonsense_Mutation	NA	Q106*	0.18
STAD	chr1	27428809	Missense_Mutation	rs779097597	V28M	0.13
STAD	chr1	27414905	Missense_Mutation	NA	R199H	0.26
THCA	chr1	27412675	Frame_Shift_Ins	novel	*V241Yfs3**	0.04
UCEC	chr1	27405762	3'UTR	novel		0.27
UCEC	chr1	27406154	3'UTR	novel		0.28
UCEC	chr1	27406485	3'UTR	novel		0.24
UCEC	chr1	27407154	3'UTR	novel		0.43
UCEC	chr1	27412637	Missense_Mutation	novel	D253E	0.39
UCEC	chr1	27405708	3'UTR	novel		0.44
UCEC	chr1	27414905	Missense_Mutation	NA	R199H	0.36
UCEC	chr1	27416029	Silent	novel	L165L	0.34
UCEC	chr1	27407989	3'UTR	novel		0.25
UCEC	chr1	27409774	Silent	rs767276618	P419P	0.17
UCEC	chr1	27412644	Missense_Mutation	novel	Q251R	0.19
UCEC	chr1	27428925	5'UTR	novel		0.26
UCEC	chr1	27416083	Missense_Mutation	rs747661986	L147F	0.36
UCEC	chr1	27405715	3'UTR	novel		0.57
UCEC	chr1	27428798	Silent	novel	I31I	0.27
UCEC	chr1	27407172	3'UTR	novel		0.45
UCEC	chr1	27408344	Missense_Mutation	novel	F448V	0.31
UCEC	chr1	27405668	3'UTR	novel		0.3
UCEC	chr1	27428791	Missense_Mutation	novel	A34S	0.39
UCEC	chr1	27409822	Silent	novel	P403P	0.24
UCEC	chr1	27428810	Silent	NA	C27C	0.47
UCEC	chr1	27408140	3'UTR	novel		0.5
UCEC	chr1	27416047	Missense_Mutation	novel	L159I	0.58
UCEC	chr1	27419029	Missense_Mutation	rs139424562	R64W	0.45
UCEC	chr1	27416073	Missense_Mutation	NA	Y150C	0.4
UCEC	chr1	27418963	Missense_Mutation	novel	E86K	0.42
UCEC	chr1	27405748	3'UTR	rs548876748		0.22
UCEC	chr1	27416015	Silent	novel	K169K	0.19
UCEC	chr1	27409735	Silent	rs760880272	A432A	0.06
UCEC	chr1	27412613	Silent	novel	S261S	0.38
UCEC	chr1	27414870	Nonsense_Mutation	novel	E211*	0.2
UCEC	chr1	27415991	Silent	NA	K177K	0.16
UCEC	chr1	27405676	3'UTR	novel		0.2
UCEC	chr1	27407223	3'UTR	novel		0.62
UCEC	chr1	27412617	Frame_Shift_Del	novel	*P260Lfs47**	0.36
UCEC	chr1	27418405	Nonsense_Mutation	novel	*N95Lfs2**	0.04
UCEC	chr1	27406481	3'UTR	novel		0.31
UCEC	chr1	27407216	3'UTR	novel		0.22
UCEC	chr1	27419084	Missense_Mutation	NA	K45N	0.39
UCEC	chr1	27409846	Silent	NA	P395P	0.21
UCEC	chr1	27418297	Missense_Mutation	novel	P131S	0.33
UCEC	chr1	27407464	3'UTR	novel		0.3
UCEC	chr1	27416099	Silent	rs187587794	D141D	0.34
UCEC	chr1	27410063	Missense_Mutation	rs775253540	P323L	0.08
UCEC	chr1	27409775	Missense_Mutation	rs148528717	P419L	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0949	0.00029523
CHOL	DEL	0.8056	3.3987e-23
DLBC	DEL	0.1458	0.011841
ESCA	DEL	0.2826	0.0012162
HNSC	DEL	0.1322	7.0766e-07
KIRC	DEL	0.1496	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LIHC	DEL	0.3514	1.6679e-20
LUAD	DEL	0.1628	0.0024765
LUSC	DEL	0.3533	2.5882e-07
MESO	DEL	0.2644	2.434e-07
READ	DEL	0.4	2.1758e-10
TGCT	DEL	0.1533	0.00046313

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.019	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
HNSC	0.033	Kaplan-Meier Survival Analysis
ESCA	0.021	Kaplan-Meier Survival Analysis
COAD	0.04	Kaplan-Meier Survival Analysis
PCPG	0.012	Kaplan-Meier Survival Analysis
LAML	0.0023	Kaplan-Meier Survival Analysis
KICH	0.029	Kaplan-Meier Survival Analysis
LIHC	0.00021	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0069	Kaplan-Meier Survival Analysis
OV	0.00035	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000158195 (Gene tree)
Gene ID: 10163
Gene Symbol: WASF2
Alias: WAVE2|SCAR2
Full Name: WASP family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 85,962 bases
Position: chr1:27,404,226-27,490,187
Accession: 12733
RBP type: non-canonical RBP
Summary: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19925864	Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate.	Cell Signal	2010 Mar	Takahashi K	doi: 10.1016/j.cellsig.2009.11.005.
19162178	Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex.	Cell Signal	2009 May	Takahashi K	doi: 10.1016/j.cellsig.2009.01.007
17591693	WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.	Mol Cell Biol	2007 Sep	Nolz JC	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536657	WASF2-201	1083	-	ENSP00000439883	281 (aa)	-	Q9Y6W5
ENST00000618852	WASF2-202	5676	-	ENSP00000483313	498 (aa)	-	Q9Y6W5

Gene Model

Click here to download ENSG00000158195's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04520	Adherens junction	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG
hsa05231	Choline metabolism in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000158195	Myocardial Infarction	2.0449012E-005	-
ENSG00000158195	Myocardial Infarction	9.3964591E-005	-
ENSG00000158195	Estradiol	2E-6	23518928

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000158195	rs11548323	1	27405147	?	Estradiol plasma levels (breast cancer)	23518928	[1.219-1.598] unit increase	1.396	EFO_0004697
ENSG00000158195	rs2504776	1	27443969	T	Systolic blood pressure	30578418	[0.2-0.38] mmHg decrease	0.2909	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000158195's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001525	angiogenesis	-	IEA	Process
GO:0001667	ameboidal-type cell migration	-	IEA	Process
GO:0001726	ruffle	-	IEA	Component
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	11130076.16417406.16483316.18560548.24705354.	IPI	Function
GO:0005769	early endosome	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005911	cell-cell junction	-	IEA	Component
GO:0006897	endocytosis	-	IEA	Process
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	9732292.	TAS	Process
GO:0010592	positive regulation of lamellipodium assembly	18560548.21107423.	IMP	Process
GO:0015629	actin cytoskeleton	10970852.	TAS	Component
GO:0016032	viral process	-	IEA	Process
GO:0016601	Rac protein signal transduction	-	IEA	Process
GO:0017124	SH3 domain binding	19798448.	IPI	Function
GO:0030027	lamellipodium	17101133.	IDA	Component
GO:0030032	lamellipodium assembly	-	IEA	Process
GO:0030036	actin cytoskeleton organization	9732292.	TAS	Process
GO:0030048	actin filament-based movement	-	IEA	Process
GO:0031209	SCAR complex	21107423.	IMP	Component
GO:0032991	protein-containing complex	25097019.	IDA	Component
GO:0035855	megakaryocyte development	-	IEA	Process
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	Process
GO:0045202	synapse	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	Process
GO:0051018	protein kinase A binding	25097019.	IPI	Function
GO:0051497	negative regulation of stress fiber assembly	21107423.	IMP	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0072673	lamellipodium morphogenesis	-	IEA	Process
GO:0098974	postsynaptic actin cytoskeleton organization	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.