EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	26285310	Missense_Mutation	novel	E64Q	0.07
BLCA	chr6	26285495	Missense_Mutation	rs780851749	S2C	0.22
BRCA	chr6	26285345	Missense_Mutation	rs751532587	Y52C	0.44
BRCA	chr6	26285263	Silent	novel	R79R	0.08
BRCA	chr6	26285375	Missense_Mutation	novel	G42D	0.13
CESC	chr6	26285170	3'UTR	rs765851662		0.35
COAD	chr6	26285477	Missense_Mutation	novel	G8E	0.27
COAD	chr6	26285254	Silent	NA	V82V	0.43
COAD	chr6	26285290	Silent	NA	A70A	0.18
COAD	chr6	26285431	Frame_Shift_Ins	NA	*L23Ffs4**	0.38
COAD	chr6	26285281	Frame_Shift_Del	novel	*Y73Qfs9**	0.1
COAD	chr6	26285050	3'Flank	novel		0.22
COAD	chr6	26285223	Nonsense_Mutation	novel	R93*	0.15
DLBC	chr6	26285192	Missense_Mutation	novel	G103D	0.4
DLBC	chr6	26285303	Missense_Mutation	novel	V66E	0.41
ESCA	chr6	26285345	Missense_Mutation	rs751532587	Y52C	0.34
GBM	chr6	26285158	3'UTR	novel		0.22
HNSC	chr6	26285203	Silent	novel	Y99Y	0.15
HNSC	chr6	26285276	Missense_Mutation	novel	E75G	0.22
KIRC	chr6	26285178	3'UTR	novel		0.23
KIRP	chr6	26285506	5'UTR	rs201746650		0.45
LIHC	chr6	26285410	Silent	novel	I30I	0.38
LUAD	chr6	26285484	Missense_Mutation	rs752058100	K6E	0.42
LUAD	chr6	26285349	Missense_Mutation	novel	I51F	0.53
LUAD	chr6	26285385	Missense_Mutation	rs769287159	A39T	0.07
LUAD	chr6	26285506	5'UTR	rs201746650		0.24
LUSC	chr6	26285503	5'UTR	rs761188495		0.52
LUSC	chr6	26285228	Frame_Shift_Del	novel	*A90Gfs?**	0.15
LUSC	chr6	26285129	3'UTR	novel		0.12
LUSC	chr6	26285164	3'UTR	novel		0.14
LUSC	chr6	26285347	Missense_Mutation	rs761771008	I51M	0.13
LUSC	chr6	26285409	Missense_Mutation	rs766453964	T31A	0.31
LUSC	chr6	26285445	Missense_Mutation	novel	H19Y	0.24
OV	chr6	26285453	Missense_Mutation	NA	A16V	0.24
OV	chr6	26285232	Missense_Mutation	novel	A90T	0.28
OV	chr6	26285359	Silent	novel	I47I	0.4
OV	chr6	26285151	3'UTR	novel		0.22
OV	chr6	26285453	Missense_Mutation	novel	A16G	0.33
OV	chr6	26285495	Missense_Mutation	rs780851749	S2C	0.13
OV	chr6	26285502	5'UTR	novel		0.14
OV	chr6	26285421	Missense_Mutation	rs778137756	I27V	0.04
PRAD	chr6	26285362	Silent	NA	R46R	0.08
READ	chr6	26285503	5'UTR	rs761188495		0.16
READ	chr6	26285057	3'Flank	novel		0.55
SKCM	chr6	26285308	Silent	NA	E64E	0.47
SKCM	chr6	26285511	5'Flank	novel		0.27
STAD	chr6	26285449	Missense_Mutation	NA	K17N	0.17
UCEC	chr6	26285277	Missense_Mutation	novel	E75Q	0.16
UCEC	chr6	26285227	Silent	novel	L91L	0.23
UCEC	chr6	26285320	Silent	novel	K60K	0.39
UCEC	chr6	26285353	Silent	rs780214864	G49G	0.12
UCEC	chr6	26285460	Missense_Mutation	novel	G14R	0.35
UCEC	chr6	26285057	3'Flank	novel		0.18
UCEC	chr6	26285440	Silent	rs376550213	R20R	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
UCS	0.028	Kaplan-Meier Survival Analysis
HNSC	0.028	Kaplan-Meier Survival Analysis
SKCM	0.017	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
COAD	0.0037	Kaplan-Meier Survival Analysis
PAAD	0.0013	Kaplan-Meier Survival Analysis
KICH	0.028	Kaplan-Meier Survival Analysis
LIHC	0.004	Kaplan-Meier Survival Analysis
LGG	0.00014	Kaplan-Meier Survival Analysis
OV	0.049	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000158406 (Gene tree)
Gene ID: 8365
Gene Symbol: HIST1H4H
Alias: H4/h|H4FH
Full Name: histone cluster 1 H4 family member h
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 8,030 bases
Position: chr6:26,277,609-26,285,638
Accession: 4788
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000634560	HIST1H4H-202	1034	-	ENSP00000489319	103 (aa)	-	P62805
ENST00000377727	HIST1H4H-201	397	-	ENSP00000366956	103 (aa)	-	P62805
ENST00000635491	HIST1H4H-204	1034	-	ENSP00000489236	103 (aa)	-	P62805
ENST00000634956	HIST1H4H-203	2163	-	ENSP00000489567	103 (aa)	-	P62805

Gene Model

Click here to download ENSG00000158406's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05034	Alcoholism	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000158406's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000158406	HIST1H4H	100	100.000	ENSG00000277157	HIST1H4D	100	100.000	Homo_sapiens
ENSG00000158406	HIST1H4H	100	100.000	ENSG00000278637	HIST1H4A	100	100.000	Homo_sapiens
ENSG00000158406	HIST1H4H	100	100.000	ENSG00000273542	HIST1H4K	100	100.000	Homo_sapiens
ENSG00000158406	HIST1H4H	100	100.000	ENSG00000197238	HIST1H4J	100	100.000	Homo_sapiens
ENSG00000158406	HIST1H4H	100	100.000	ENSMUSG00000060093	Hist1h4a	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	-	TAS	Process
GO:0000228	nuclear chromosome	14718166.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000786	nucleosome	21636898.24699735.25615412.	IDA	Component
GO:0000786	nucleosome	3035717.	TAS	Component
GO:0000788	nuclear nucleosome	20498094.	IDA	Component
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	3035717.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	14585971.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006334	nucleosome assembly	21873635.	IBA	Process
GO:0006334	nucleosome assembly	20498094.21636898.24699735.25615412.	IDA	Process
GO:0006335	DNA replication-dependent nucleosome assembly	14718166.	IDA	Process
GO:0006336	DNA replication-independent nucleosome assembly	14718166.	IDA	Process
GO:0006352	DNA-templated transcription, initiation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016233	telomere capping	-	TAS	Process
GO:0019904	protein domain specific binding	22368283.	IPI	Function
GO:0032200	telomere organization	17675446.	TAS	Process
GO:0032991	protein-containing complex	14718166.	IDA	Component
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045653	negative regulation of megakaryocyte differentiation	18474616.	IDA	Process
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0051290	protein heterotetramerization	20498094.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.