EuRBPDB

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BRCA	chr1	159782260	Silent	novel	I125I	0.24
BRCA	chr1	159782228	Missense_Mutation	novel	G115R	0.06
BRCA	chr1	159782432	3'UTR	novel		0.32
COAD	chr1	159781305	Missense_Mutation	novel	P69A	0.16
COAD	chr1	159782390	3'UTR	novel		0.11
COAD	chr1	159782389	3'UTR	novel		0.23
GBM	chr1	159782291	Missense_Mutation	novel	Y136H	0.03
HNSC	chr1	159782332	Silent	novel	T149T	0.28
KIRP	chr1	159782251	Silent	novel	I122I	0.51
LIHC	chr1	159782176	Silent	novel	L97L	0.05
LUSC	chr1	159782294	Missense_Mutation	novel	E137Q	0.16
LUSC	chr1	159782352	3'UTR	novel		0.38
OV	chr1	159782227	Silent	novel	R114R	0.14
STAD	chr1	159782321	Missense_Mutation	novel	Y146D	0.29
UCEC	chr1	159782328	Missense_Mutation	rs756864682	R148Q	0.57
UCEC	chr1	159782331	Missense_Mutation	novel	T149M	0.04
UCEC	chr1	159782225	Missense_Mutation	rs200214393	R114W	0.35
UCEC	chr1	159782389	3'UTR	novel		0.31
UCEC	chr1	159782165	Missense_Mutation	novel	H94Y	0.18
UCEC	chr1	159782284	Silent	novel	I133I	0.3
UCEC	chr1	159782457	3'UTR	novel		0.26
UCEC	chr1	159782379	3'UTR	novel		0.52
UCEC	chr1	159782396	3'UTR	novel		0.18
UCEC	chr1	159782519	3'UTR	novel		0.22
UCEC	chr1	159782389	3'UTR	novel		0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.413	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2174	0.085665
READ	AMP	0.2727	0.025154
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.3333	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
ACC	0.03	Kaplan-Meier Survival Analysis
SKCM	0.038	Kaplan-Meier Survival Analysis
LAML	0.00094	Kaplan-Meier Survival Analysis
GBM	0.0055	Kaplan-Meier Survival Analysis
LIHC	0.0016	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis

Description

Ensembl ID: ENSG00000158716 (Gene tree)
Gene ID: 54935
Gene Symbol: DUSP23
Alias: FLJ20442|DUSP25
Full Name: dual specificity phosphatase 23
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 1,612 bases
Position: chr1:159,780,932-159,782,543
Accession: 21480
RBP type: non-canonical RBP
Summary: (Dual Specificity Phosphatase 23) is a Protein Coding gene. Diseases associated with DUSP23 include Neuronal Intestinal Dysplasia. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368107	DUSP23-201	756	-	ENSP00000357087	150 (aa)	-	Q9BVJ7
ENST00000368109	DUSP23-203	729	-	ENSP00000357089	150 (aa)	-	Q9BVJ7
ENST00000368108	DUSP23-202	694	-	ENSP00000357088	150 (aa)	-	Q9BVJ7

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000158716	Monocytes	2.9020000E-005	-
ENSG00000158716	Platelet Function Tests	3.7000000E-006	-
ENSG00000158716	Platelet Function Tests	3.6900000E-006	-
ENSG00000158716	Platelet Function Tests	2.1161433E-006	-
ENSG00000158716	Platelet Function Tests	1.1102230E-015	-
ENSG00000158716	Lung Diseases, Interstitial	9E-6	21787189

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0004725	protein tyrosine phosphatase activity	21873635.	IBA	Function
GO:0005515	protein binding	25416956.25910212.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	17498703.	IDA	Function
GO:0016311	dephosphorylation	24531476.	IDA	Process
GO:0016791	phosphatase activity	24531476.	IDA	Function
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IEA	Process