EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28486549Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation.PLoS One2017 May 9Sorenson ECdoi: 10.1371/journal.pone.0176562
26561465MicroRNA-150 functions as a tumor suppressor in osteosarcoma by targeting IGF2BP1.Tumour Biol2016 AprQu Ydoi: 10.1007/s13277-015-4389-8
22279049IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.Genes Dev2012 Jan 15Sthr Ndoi: 10.1101/gad.177642.111.
25861986Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells.J Biol Chem2015 May 22Fakhraldeen SAdoi: 10.1074/jbc.M115.655175
26194191Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.Mol Cancer Res2015 NovHamilton KEdoi: 10.1158/1541-7786.MCR-15-0224
22983196 of tumor cell migration.Cell Adh Migr2012 Jul-AugSthr Ndoi: 10.4161/cam.20628
26917013The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family.Nucleic Acids Res2016 May 5Busch Bdoi: 10.1093/nar/gkw099
26910917IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs.Oncotarget2016 Mar 29Wang Gdoi: 10.18632/oncotarget.7464.
18490442Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells.Mol Cell Biol2008 AugGu Wdoi: 10.1128/MCB.00266-08
17255263Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.Clin Cancer Res2007 Jan 15Kato T-
21252116IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.Cancer Res2011 Mar 15Mongroo PSdoi: 10.1158/0008-5472.CAN-10-3295
14767552Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer.Int J Oncol2004 MarGu L-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1749039963Missense_MutationnovelD230E0.05
ACCchr1749044015Missense_MutationnovelV417L0.5
BLCAchr1748997844Missense_MutationnovelF33L0.1KH_1
BLCAchr1749038299Missense_MutationnovelR178H0.45
BLCAchr1749026495SilentnovelG105G0.37
BLCAchr1748999142Missense_MutationnovelI70T0.69
BLCAchr1749031952Missense_MutationnovelS127C0.1
BLCAchr1748997772SilentnovelL9L0.38
BLCAchr1749031929Silentrs201903108T119T0.13
BLCAchr17489976845'UTRnovel0.13
BLCAchr1749038174Missense_MutationnovelI136M0.18
BLCAchr1749043973Missense_MutationnovelP403A0.26
BRCAchr17489975415'UTRnovel0.47
BRCAchr1749038266Missense_Mutationrs557111796R167H0.14
BRCAchr17490501823'UTRnovel0.33
BRCAchr17490548823'UTRnovel0.2
BRCAchr1749039991Missense_MutationNAA240T0.42
BRCAchr1749031924Nonsense_MutationnovelE118*0.1
BRCAchr1748997919Splice_RegionnovelS58S0.1
BRCAchr1749041459SilentNAK300K0.25
CESCchr17489976915'UTRnovel0.39
CESCchr17490495223'UTRnovel0.13
CESCchr17490511443'UTRnovel0.38
CESCchr1749026494Missense_MutationNAG105A0.15
CESCchr17490541343'UTRnovel0.4
CESCchr1749045937SilentnovelG481G0.3
CESCchr1749045051Missense_MutationNAE461K0.31
CESCchr17489976155'UTRnovel0.32
CESCchr1749044086Missense_MutationNAK440N0.13
CESCchr17490551013'UTRnovel0.09
CESCchr17490533973'UTRnovel0.31
CESCchr1749045995Missense_Mutationrs781338712R501W0.21
CESCchr1749042270Missense_MutationNAE324K0.34
COADchr1749042290Frame_Shift_DelNAA332Pfs*120.33
COADchr1748999168Splice_RegionnovelR79R0.24
COADchr1749038361Missense_MutationNAR199W0.26
COADchr1749042342Missense_MutationnovelR348W0.43
COADchr1749031913Missense_MutationNAN114S0.28
COADchr1749040072Nonsense_MutationNAE267*0.4
COADchr1749046345Missense_MutationNAK538I0.23
COADchr1749038422Missense_MutationNAR219H0.15
COADchr1749045047Silentrs754609010P459P0.12
COADchr1749038268Nonsense_MutationNAR168*0.35
COADchr1749038321Silentrs774524369A185A0.3
COADchr1749046282Missense_MutationnovelT517M0.29
COADchr1749046303Missense_MutationNAP524L0.22
COADchr1748997829SilentnovelS28S0.13
COADchr1749045983Missense_MutationNAS497A0.26
COADchr1749046001Missense_MutationNAI503V0.2
COADchr1749042299SilentNAI333I0.26
COADchr1749042302Missense_MutationNAE334D0.09
COADchr1749025638Missense_MutationnovelR86Q0.11
COADchr1749039995Frame_Shift_DelnovelA243Pfs*170.08
COADchr1749038286Missense_Mutationrs779507141R174W0.08
COADchr1749042300Missense_Mutationrs752711229E334K0.3
ESCAchr17490509823'UTRnovel0.06
ESCAchr17490552533'UTRnovel0.47
ESCAchr17490545053'UTRnovel0.36
ESCAchr1749026506Missense_MutationnovelN109S0.26
ESCAchr17490511373'UTRnovel0.39
ESCAchr17490539923'UTRnovel0.28
GBMchr1749049440Missense_MutationnovelK577M0.14
GBMchr1749039989Missense_MutationnovelA239G0.08
GBMchr1749046353Missense_MutationNAG541R0.37
GBMchr17489977305'UTRnovel0.16
GBMchr1749038372SilentnovelV202V0.16
GBMchr1749038265Missense_MutationNAR167C0.45
GBMchr1749040092Splice_SiteNAX273_splice0.73
GBMchr1749038286Missense_Mutationrs779507141R174W0.17
GBMchr1749045024Missense_MutationNAR452C0.51
GBMchr17490495553'UTRnovel0.21
GBMchr1749045030Missense_MutationnovelV454F0.04
GBMchr1749041470Missense_MutationNAQ304P0.29
HNSCchr1748999132Missense_MutationnovelR67C0.14KH_1
HNSCchr1749046290Missense_MutationnovelE520K0.2
HNSCchr17490495473'UTRnovel0.3
HNSCchr1748999117Missense_MutationnovelE62Q0.17KH_1
HNSCchr1749040057Missense_MutationnovelE262K0.09
KIRPchr1748997823SilentnovelK26K0.2
LGGchr1749043505Silentrs369774252P385P0.45
LGGchr1749049417SilentnovelS569S0.37
LGGchr1749042318Missense_MutationnovelE340K0.22
LGGchr1749044995Missense_MutationNAA442V0.29
LIHCchr1749040092Splice_SiteNAX273_splice0.39
LUADchr1749038412Missense_MutationNAA216T0.33
LUADchr1749045016Missense_MutationnovelS449Y0.2
LUADchr1749046334Missense_MutationNAQ534H0.24
LUADchr1749031968SilentnovelT132T0.11
LUADchr1749043525Missense_MutationNAG392E0.33
LUADchr1748997776Missense_MutationNAE11K0.27KH_1
LUADchr1749044040Missense_MutationnovelG425V0.29
LUADchr1749039983Missense_MutationNAA237V0.23
LUADchr1749038228SilentnovelI154I0.25
LUADchr1749044990Splice_SitenovelX441_splice0.4
LUADchr1749038269Missense_MutationNAR168Q0.12
LUADchr1748997797Missense_MutationnovelL18M0.23KH_1
LUADchr1749045024Missense_MutationNAR452G0.29
LUADchr1749044041Silentrs763132170G425G0.47
LUADchr1748999151Missense_MutationnovelS73L0.1
LUADchr1749043504Missense_Mutationrs748846744P385Q0.21
LUADchr1749043461Missense_MutationnovelA371S0.4
LUADchr1749038238Missense_Mutationrs762860271Q158E0.18
LUADchr1748997772SilentnovelL9L0.17
LUADchr17489976005'UTRnovel0.23
LUSCchr1749045887Splice_Regionnovel0.13
LUSCchr1749049420Missense_MutationNAN570K0.12
LUSCchr1748997894Missense_MutationnovelA50V0.14KH_1
LUSCchr1749040072Missense_MutationnovelE267Q0.17
LUSCchr1749043516Missense_MutationNAS389I0.28
LUSCchr1749040072Missense_MutationnovelE267K0.37
LUSCchr17489975755'UTRnovel0.75
LUSCchr1749038332Missense_MutationnovelA189G0.34
LUSCchr1749044996SilentNAA442A0.12
LUSCchr1749038269Missense_MutationNAR168Q0.1
LUSCchr1749031958Missense_MutationnovelR129L0.4
LUSCchr1749043964Splice_Regionnovel0.14
LUSCchr1749045922SilentNAE476E0.19
LUSCchr1749049369SilentnovelI553I0.2
LUSCchr1749038294SilentnovelQ176Q0.23
LUSCchr1749045003Nonsense_MutationNAE445*0.52
OVchr1748997782Missense_MutationNAV13M0.69KH_1
OVchr1748997900Missense_Mutationrs200362453K52R0.15KH_1
OVchr1749049393Missense_MutationnovelK561N0.1
OVchr1749041449In_Frame_InsnovelR297_N298insK0.18
OVchr1749041451In_Frame_InsnovelN298delinsSWDYRRVPPH0.16
OVchr1749044024Missense_MutationnovelI420V0.04
OVchr1749040081Missense_MutationnovelD270N0.05
PAADchr17489975855'UTRnovel0.11
PAADchr1748997814SilentnovelA23A0.22
PAADchr1749046287Missense_MutationnovelA519T0.15
PAADchr1749049399Missense_MutationnovelQ563H0.09
PRADchr1749044038Frame_Shift_DelnovelQ426Sfs*610.3
PRADchr1749043985Missense_Mutationrs574660242M407V0.49
PRADchr1749038250Missense_MutationNAG162R0.12
READchr1749038287Missense_Mutationrs746549698R174Q0.34
READchr1749040039Missense_Mutationrs777305494A256T0.25
READchr1749038201Missense_MutationnovelE145D0.52
READchr1749039982Missense_Mutationrs375360274A237T0.42
READchr1749042300Missense_Mutationrs752711229E334K0.36
SARCchr1749038287Missense_Mutationrs746549698R174Q0.38
SARCchr1749044025Missense_MutationnovelI420T0.28
SARCchr17490508463'UTRnovel0.15
SARCchr1749045065Splice_RegionnovelK465K0.34
SARCchr17490544073'UTRnovel0.25
SARCchr1749040018Missense_MutationnovelT249S0.31
SARCchr17490541143'UTRnovel0.89
SKCMchr1749038251Missense_MutationnovelG162E0.15
SKCMchr1749038265Missense_MutationNAR167C0.22
SKCMchr1749025638Missense_MutationnovelR86Q0.47
SKCMchr1749042326Missense_MutationnovelE342D0.42
SKCMchr1749045024Missense_MutationNAR452C0.48
SKCMchr1749041441SilentNAK294K0.1
SKCMchr1749044022Missense_MutationNAA419V0.2
SKCMchr1749040034Missense_MutationNAS254F0.47
SKCMchr17490494703'UTRnovel0.37
SKCMchr1748997789Missense_MutationnovelP15L0.25KH_1
SKCMchr1749045895SilentnovelQ467Q0.1
SKCMchr1749049420SilentnovelN570N0.62
SKCMchr1749042266SilentnovelN322N0.14
SKCMchr1749049438SilentNAR576R0.28
SKCMchr1749043973Missense_MutationnovelP403S0.47
SKCMchr1749042324Missense_MutationNAE342K0.32
SKCMchr1749045048Missense_MutationNAP460S0.43
SKCMchr1749041495SilentNAI312I0.42
SKCMchr1749049383Missense_MutationNAA558G0.38
SKCMchr1749045024Missense_MutationNAR452C0.43
SKCMchr1749041500Missense_Mutationrs368120375S314L0.3
SKCMchr1749046299Missense_MutationNAV523I0.38
SKCMchr1749031953SilentnovelS127S0.07
SKCMchr1749045936Missense_MutationNAG481D0.32
SKCMchr17490494943'UTRnovel0.56
SKCMchr1748999158SilentNAP75P0.14
SKCMchr1749038297SilentNAP177P0.4
SKCMchr1749046366Missense_MutationNAA545V0.35
SKCMchr1749045024Missense_MutationNAR452C0.2
SKCMchr1749045920Missense_Mutationrs267604937E476K0.44
SKCMchr1749045899Missense_MutationNAR469G0.54
SKCMchr1749045046Missense_Mutationrs751061699P459L0.45
SKCMchr1749045952SilentNAV486V0.24
SKCMchr1748999109Missense_MutationnovelG59E0.19KH_1
SKCMchr1749042324Missense_MutationNAE342K0.98
SKCMchr1749041391Missense_MutationNAP278S0.23
SKCMchr1749025664Missense_MutationNAE95K0.17
SKCMchr1749042324Missense_MutationNAE342K0.78
SKCMchr17489976235'UTRnovel1
SKCMchr1749042324Missense_MutationNAE342K0.42
SKCMchr1748999157Missense_MutationNAP75L0.31
STADchr17489977265'UTRnovel0.25
STADchr1749041468Missense_MutationNAE303D0.2
STADchr1749046297Missense_MutationNAV522A0.05
STADchr1749038354Frame_Shift_DelnovelL198Ffs*320.17
STADchr1749049423Frame_Shift_DelnovelA572Pfs*530.33
STADchr1749046361Missense_MutationNAF543L0.46
STADchr1749044051Missense_MutationNAK429E0.23
STADchr1748999140Missense_MutationNAE69D0.12
STADchr1749038266Missense_Mutationrs557111796R167H0.06
STADchr1749038286Missense_Mutationrs779507141R174W0.16
STADchr1748997922Splice_SiteNAX59_splice0.1
STADchr17489977025'UTRnovel0.13
STADchr1749045995Missense_Mutationrs781338712R501W0.33
THYMchr1749045986Missense_MutationNAA498T0.12
UCECchr1749045047Silentrs754609010P459P0.48
UCECchr1748997913SilentNAT56T0.31
UCECchr1749044080SilentNAS438S0.37
UCECchr1749045024Missense_MutationNAR452C0.37
UCECchr1749046328Silentrs151135710N532N0.28
UCECchr1749046346Missense_MutationnovelK538N0.15
UCECchr17490528323'UTRnovel0.3
UCECchr1749040002SilentnovelA243A0.06
UCECchr1749049362Missense_MutationnovelR551Q0.41
UCECchr17490526453'UTRnovel0.33
UCECchr17490503423'UTRnovel0.28
UCECchr17490509823'UTRnovel0.47
UCECchr1749041407Missense_Mutationrs531902165A283V0.19
UCECchr17489977445'UTRrs7807312930.38
UCECchr1749038422Missense_MutationNAR219H0.2
UCECchr17490511453'UTRnovel0.4
UCECchr1749046361Missense_MutationNAF543L0.36
UCECchr17490494883'UTRnovel0.45
UCECchr1749041406Missense_MutationnovelA283S0.39
UCECchr17490495223'UTRnovel0.44
UCECchr1749046293Missense_MutationnovelV521M0.28
UCECchr17490527983'UTRnovel0.44
UCECchr17490526683'UTRnovel0.57
UCECchr1749043993SilentNAQ409Q0.16
UCECchr17490527993'UTRnovel0.57
UCECchr1749045024Missense_MutationNAR452C0.22
UCECchr1749038265Missense_MutationNAR167C0.36
UCECchr17490533453'UTRrs3690686910.4
UCECchr17490528323'UTRnovel0.24
UCECchr17490527993'UTRnovel0.75
UCECchr1748997844Missense_MutationnovelF33L0.38KH_1
UCECchr1749040044SilentnovelC257C0.5
UCECchr1749042317SilentnovelA339A0.4
UCECchr17490538913'UTRnovel0.3
UCECchr17490511383'UTRnovel0.4
UCECchr17490533413'UTRnovel0.27
UCECchr17490539393'UTRnovel0.17
UCECchr17490501103'UTRnovel0.13
UCECchr17490551613'UTRnovel0.36
UCECchr17489975615'UTRnovel0.18
UCECchr1749038353Missense_MutationnovelI196T0.26
UCECchr1749038448Missense_MutationNAK228E0.25
UCECchr17490511453'UTRnovel0.28
UCECchr1749043494Missense_Mutationrs377397969A382T0.33
UCECchr1749038358Missense_MutationNAL198I0.32
UCECchr17490511453'UTRrs7676133640.44
UCECchr17490534743'UTRnovel0.5
UCECchr17490539593'UTRnovel0.13
UCECchr17490550323'UTRnovel0.36
UCECchr1749038362Missense_Mutationrs752960224R199Q0.64
UCECchr1749046353Missense_MutationNAG541R0.09
UCECchr17490545023'UTRnovel0.45
UCECchr1749041457Missense_MutationnovelK300E0.45
UCECchr1749042300Missense_Mutationrs752711229E334K0.38
UCECchr17490509543'UTRnovel0.53
UCECchr17490500723'UTRnovel0.44
UCECchr17490542653'UTRnovel0.31
UCECchr17490551613'UTRnovel0.52
UCECchr17490549813'UTRnovel0.48
UCECchr1749038401Missense_MutationNAG212D0.4
UCECchr17490528323'UTRnovel0.52
UCECchr1749043993Missense_MutationNAQ409H0.43
UCECchr1749040089Missense_MutationnovelK272N0.25
UCECchr1749041464Missense_MutationnovelV302A0.31
UCECchr17490511613'UTRnovel0.29
UCECchr1749025629Missense_MutationNAI83T0.31
UCECchr1749038232Missense_MutationnovelD156N0.2
UCECchr17490541003'UTRnovel0.16
UCECchr17490550333'UTRnovel0.17
UCECchr1749046303Missense_MutationnovelP524Q0.33
UCECchr1749031929Silentrs201903108T119T0.33
UCECchr17490511383'UTRnovel0.41
UCECchr17490541193'UTRnovel0.17
UCECchr17490501313'UTRrs3707076280.39
UCECchr17490501393'UTRnovel0.64
UCECchr17490511453'UTRnovel0.44
UCECchr1749042302Missense_MutationNAE334D0.23
UCECchr17490512123'UTRnovel0.18
UCECchr17490513723'UTRnovel0.44
UCECchr17490511453'UTRrs7676133640.38
UCECchr17490495003'UTRrs3714946150.33
UCECchr1749041501Splice_Siters751435920X314_splice0.45
UCECchr1749040023SilentnovelP250P0.17
UCECchr17490512393'UTRnovel0.36
UCECchr17490527453'UTRnovel0.57
UCECchr1749040039Missense_Mutationrs777305494A256T0.41
UCECchr17490511383'UTRnovel0.51
UCECchr17490550833'UTRnovel0.38
UCECchr17490495903'UTRnovel0.2
UCECchr1749041385Missense_Mutationrs747039976E276K0.34
UCECchr1749031928Missense_Mutationrs757274629T119M0.14
UCECchr1749038405Missense_MutationnovelK213N0.2
UCECchr1749039956Splice_SitenovelX228_splice0.45
UCECchr1749041427Missense_MutationnovelR290C0.26
UCECchr1749042300Missense_Mutationrs752711229E334K0.23
UCECchr17490511433'UTRnovel0.35
UCECchr17490542913'UTRnovel0.29
UCECchr17490511383'UTRnovel0.41
UCECchr17490527993'UTRnovel0.32
UCECchr1748997863Missense_MutationnovelA40T0.45KH_1
UCECchr1749031918Missense_MutationnovelE116K0.35
UCECchr1749049434Missense_Mutationrs749541733R575Q0.37
UCECchr17490503163'UTRrs5673614650.42
UCECchr17490508293'UTRnovel0.5
UCECchr17490509813'UTRnovel0.47
UCECchr17490542773'UTRnovel0.57
UCECchr1749038232Missense_MutationnovelD156N0.56
UCSchr17490494553'UTRnovel0.38
UCSchr1748997868Missense_MutationnovelF41L0.13KH_1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.02080.18166
KIRPAMP0.65280.14801
THCADEL0.0020.221
UCSDEL0.19640.19877
UVMDEL0.01250.22482

Survival Analysis
CancerP-value Q-value
KIRC0.0019

Kaplan-Meier Survival Analysis

STAD0.013

Kaplan-Meier Survival Analysis

SARC0.012

Kaplan-Meier Survival Analysis

MESO0.00023

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

UCS0.0085

Kaplan-Meier Survival Analysis

BRCA0.007

Kaplan-Meier Survival Analysis

KIRP0.004

Kaplan-Meier Survival Analysis

PAAD0.018

Kaplan-Meier Survival Analysis

READ0.038

Kaplan-Meier Survival Analysis

KICH0.018

Kaplan-Meier Survival Analysis

UCEC0.0001

Kaplan-Meier Survival Analysis

LIHC0.00076

Kaplan-Meier Survival Analysis

DLBC0.048

Kaplan-Meier Survival Analysis

LGG0.00035

Kaplan-Meier Survival Analysis

THCA0.008

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

UVM0.013

Kaplan-Meier Survival Analysis

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000159217 (Gene tree)
Gene ID
10642
Gene Symbol
IGF2BP1
Alias
IMP-1
Full Name
insulin like growth factor 2 mRNA binding protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
58,734 bases
Position
chr17:48,997,412-49,056,145
Accession
28866
RBP type
canonical RBP
Summary
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000290341KH_1PF00013.293.2e-5514
ENSP00000290341KH_1PF00013.293.2e-5524
ENSP00000290341KH_1PF00013.293.2e-5534
ENSP00000290341KH_1PF00013.293.2e-5544
ENSP00000389135KH_1PF00013.299.3e-4213
ENSP00000389135KH_1PF00013.299.3e-4223
ENSP00000389135KH_1PF00013.299.3e-4233
ENSP00000290341RRM_1PF00076.224.2e-1612
ENSP00000290341RRM_1PF00076.224.2e-1622
ENSP00000389135RRM_1PF00076.221.9e-1111
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28882869Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration.Arterioscler Thromb Vasc Biol2018 JanNguyen MAdoi: 10.1161/ATVBAHA.117.309795
22465430Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice.Gastroenterology2012 JulManieri NAdoi: 10.1053/j.gastro.2012.03.037
18490442Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells.Mol Cell Biol2008 AugGu Wdoi: 10.1128/MCB.00266-08
30864660IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.Nucleic Acids Res2019 May 7Dagil Rdoi: 10.1093/nar/gkz136.
15769738CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells.J Biol Chem2005 May 20Ioannidis P-
19029303Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.RNA2009 JanWeidensdorfer Ddoi: 10.1261/rna.1175909
12573215Real-time visualization of ZBP1 association with beta-actin mRNA during transcription and localization.Curr Biol2003 Feb 4Oleynikov Y-
16476777A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP.J Cell Biol2006 Feb 13Munro TP-
15159028Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors.Cancer Lett2004 Jun 25Ioannidis P-
23640942Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.Biol Chem2013 AugWachter Kdoi: 10.1515/hsz-2013-0111.
20439467MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein.J Biol Chem2010 Jul 2Goswami Sdoi: 10.1074/jbc.M110.109298
25414259MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP).J Biol Chem2015 Jan 2Goswami Sdoi: 10.1074/jbc.M114.590158
29463567Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules.J Cell Biol2018 Apr 2Niewidok Bdoi: 10.1083/jcb.201709007
9801297The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins.Nucleic Acids Res1998 Nov 15Doyle GA-
16778892CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.Nature2006 Jun 15Noubissi FK-
22983196 of tumor cell migration.Cell Adh Migr2012 Jul-AugStohr Ndoi: 10.4161/cam.20628
23388827mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.Genes Dev2013 Feb 1Dai Ndoi: 10.1101/gad.209130.112.
22279049IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.Genes Dev2012 Jan 15Stohr Ndoi: 10.1101/gad.177642.111.
21779431Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions.Genes Cancer2010 OctNoubissi FKdoi: 10.1177/1947601910395581.
23853158RNA-binding protein Vg1RBP regulates terminal arbor formation but not long-range axon navigation in the developing visual system.Dev Neurobiol2014 MarKalous Adoi: 10.1002/dneu.22110
23764754IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts.Carcinogenesis2013 NovHamilton KEdoi: 10.1093/carcin/bgt217
26852652ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.Blood Cells Mol Dis2016 MarStoskus Mdoi: 10.1016/j.bcmd.2015.11.006
27239736Defining the significance of IGF2BP1 overexpression in t(12;21)(p13;q22)-positive leukemia REH cells.Leuk Res2016 AugStoskus Mdoi: 10.1016/j.leukres.2016.05.009
30407516IMP1 3' UTR shortening enhances metastatic burden in colorectal cancer.Carcinogenesis2019 Jun 10Andres SFdoi: 10.1093/carcin/bgy153.
30936459Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis.Oncogene2019 MayGhoshal Adoi: 10.1038/s41388-019-0797-3
16356927The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex.Nucleic Acids Res2005 Dec 14Patel GP-
16009965Developmental and regional expression and localization of mRNAs encoding proteins involved in RNA translocation.J Histochem Cytochem2005 DecIslam S-
19111951Embryonic expression of Drosophila IMP in the developing CNS and PNS.Gene Expr Patterns2009 MarAdolph SKdoi: 10.1016/j.gep.2008.12.001
17415713Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer.Int J Cancer2007 Aug 1Dimitriadis E-
27036131Inhibition of GLI1 Expression by Targeting the CRD-BP-GLI1 mRNA Interaction Using a Specific Oligonucleotide.Mol Pharmacol2016 JunMehmood Kdoi: 10.1124/mol.115.102434
29669595IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p.Breast Cancer Res2018 Apr 18Zhou Ydoi: 10.1186/s13058-018-0959-1.
16049158Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.Reproduction2005 AugHammer NA-
15121863Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice.Mol Cell Biol2004 MayHansen TV-
23069990Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?Cell Mol Life Sci2013 AugBell JLdoi: 10.1007/s00018-012-1186-z
18454174Overexpression of mRNA-binding protein CRD-BP in malignant melanomas.Oncogene2008 Aug 28Elcheva Idoi: 10.1038/onc.2008.141
17212783IMP1 interacts with poly(A)-binding protein (PABP) and the autoregulatory translational control element of PABP-mRNA through the KH III-IV domain.FEBS J2006 DecPatel GP-
22215810Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control.Genes Dev2012 Jan 1Patel VLdoi: 10.1101/gad.177428.111.
27791158Glutamate-induced RNA localization and translation in neurons.Proc Natl Acad Sci U S A2016 Nov 1Yoon YJ-
25861986Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells.J Biol Chem2015 May 22Fakhraldeen SAdoi: 10.1074/jbc.M115.655175
9178888Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro.Oncogene1997 Mar 20Leeds P-
9121465Characterization of a beta-actin mRNA zipcode-binding protein.Mol Cell Biol1997 AprRoss AF-
12921532Nuclear transit of human zipcode-binding protein IMP1.Biochem J2003 Dec 1Nielsen J-
12716932Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons.J Neurosci2003 Apr 15Tiruchinapalli DM-
12415010RNA trafficking and stabilization elements associate with multiple brain proteins.J Cell Sci2002 Dec 1Snee M-
10692488Inhibition of c-myc expression in cells by targeting an RNA-protein interaction using antisense oligonucleotides.Mol Pharmacol2000 MarCoulis CM-
15601260VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.Biol Cell2005 JanYisraeli JK-
15355996Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells.J Biol Chem2004 Nov 19Liao B-
19887615Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA.Cancer Res2009 Nov 15Noubissi FKdoi: 10.1158/0008-5472.CAN-09-1500
19647510MicroRNAs cross the line: the battle for mRNA stability enters the coding sequence.Mol Cell2009 Jul 31Nielsen AFdoi: 10.1016/j.molcel.2009.07.006.
19647520CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation.Mol Cell2009 Jul 31Elcheva Idoi: 10.1016/j.molcel.2009.06.007.
17546046Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma.Oncogene2007 Nov 29Kobel M-
22523568RACK1 is a ribosome scaffold protein for β-actin mRNA/ZBP1 complex.PLoS One2012Ceci Mdoi: 10.1371/journal.pone.0035034
22240322Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning.Learn Mem2012 Jan 12Lapidus KAdoi: 10.1101/lm.024471.111
22125086The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.Hum Mutat2012 MarNordin Adoi: 10.1002/humu.22002
20459747Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1.Retrovirology2010 May 10Milev MPdoi: 10.1186/1742-4690-7-41.
25488811Stress granules are dispensable for mRNA stabilization during cellular stress.Nucleic Acids Res2015 Feb 27Bley Ndoi: 10.1093/nar/gku1275
24395596Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma.Hepatology2014 MayGutschner Tdoi: 10.1002/hep.26997
27856289RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma.J Invest Dermatol2017 MarKim Tdoi: 10.1016/j.jid.2016.10.042
26325373The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo.PLoS One2015 Sep 1Gaynes JAdoi: 10.1371/journal.pone.0134751
28497370IGF2BP1: a novel binding protein of p38 MAPK.Mol Cell Biochem2017 NovRini Jdoi: 10.1007/s11010-017-3062-5
30581152p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.Cancer Cell2019 Jan 14Karras Pdoi: 10.1016/j.ccell.2018.11.008
29263157SRC Increases MYC mRNA Expression in Estrogen Receptor-Positive Breast Cancer via mRNA Stabilization and Inhibition of p53 Function.Mol Cell Biol2018 Feb 27Abdullah Cdoi: 10.1128/MCB.00463-17
31061170Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.EMBO Rep2019 JunChatterji Pdoi: 10.15252/embr.201847074
31186239Dynamic expression of tRNA-derived small RNAs define cellular states.EMBO Rep2019 Jun 11Krishna Sdoi: 10.15252/embr.201947789
31267708Dynamic expression of tRNA-derived small RNAs define cellular states.EMBO Rep2019 JulKrishna Sdoi: 10.15252/embr.201947789
24965446Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.J Virol2014 SepJefferson Mdoi: 10.1128/JVI.00984-14
28182633Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction.PLoS One2017 Feb 9Rensburg GVdoi: 10.1371/journal.pone.0171196
30894375The Critical Role of RNA m6A Methylation in Cancer.Cancer Res2019 Apr 1Lan Qdoi: 10.1158/0008-5472.CAN-18-2965
20494969Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNA.RNA2010 JulKohn Mdoi: 10.1261/rna.2152710
24719423hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication.J Virol2014 JulLi Ydoi: 10.1128/JVI.00225-14
16448619Analysis of RNA-protein interactions by a microplate-based fluorescence anisotropy assay.Anal Biochem2006 Mar 15Mao C-
15282548Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs.EMBO J2004 Aug 18Rackham O-
25389298Molecular insights into the coding region determinant-binding protein-RNA interaction through site-directed mutagenesis in the heterogeneous nuclear ribonucleoprotein-K-homology domains.J Biol Chem2015 Jan 2Barnes Mdoi: 10.1074/jbc.M114.614735
24397586Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability.FEBS J2014 FebYang Fdoi: 10.1111/febs.12625
11713986A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.Scand J Clin Lab Invest Suppl2001Nielsen FC-
16306994Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.Nature2005 Nov 24Huttelmaier S-
15314207Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability.Nucleic Acids Res2004 Aug 16Nielsen J-
14729626Mammary tumor induction in transgenic mice expressing an RNA-binding protein.Cancer Res2004 Jan 1Tessier CR-
20080952ZBP1 recognition of beta-actin zipcode induces RNA looping.Genes Dev2010 Jan 15Chao JAdoi: 10.1101/gad.1862910.
17264115CRD-BP shields c-myc and MDR-1 RNA from endonucleolytic attack by a mammalian endoribonuclease.Nucleic Acids Res2007Sparanese D-
22279044A zipcode unzipped.Genes Dev2012 Jan 15Doyle Mdoi: 10.1101/gad.184945.111.
22114317The zipcode-binding protein ZBP1 influences the subcellular location of the Ro 60-kDa autoantigen and the noncoding Y3 RNA.RNA2012 JanSim Sdoi: 10.1261/rna.029207.111
24622399Assessing specific oligonucleotides and small molecule antibiotics for the ability to inhibit the CRD-BP-CD44 RNA interaction.PLoS One2014 Mar 12King DTdoi: 10.1371/journal.pone.0091585
23911878IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1.Gynecol Oncol2013 OctHsieh YTdoi: 10.1016/j.ygyno.2013.07.106
23728852Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1).Hepatology2013 NovHammerle Mdoi: 10.1002/hep.26537
27068461Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.Cell Rep2016 Apr 19Conway AEdoi: 10.1016/j.celrep.2016.03.052
26152301Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1.Nucleic Acids Res2015 Sep 3Kim HHdoi: 10.1093/nar/gkv699
30104206Characterizing the interaction between insulin-like growth factor 2 mRNA-binding protein 1 (IMP1) and KRAS expression.Biochem J2018 Sep 5Mackedenski Sdoi: 10.1042/BCJ20180575.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000510023IGF2BP1-205754--- (aa)--
ENST00000290341IGF2BP1-2018274XM_005256955ENSP00000290341577 (aa)XP_005257012Q9NZI8
ENST00000499130IGF2BP1-203568--- (aa)--
ENST00000431824IGF2BP1-2021317-ENSP00000389135438 (aa)-Q9NZI8
ENST00000505562IGF2BP1-204461--- (aa)--
ENST00000515586IGF2BP1-206768--- (aa)--
Gene Model
Click here to download ENSG00000159217's gene model file
Pathways
Pathway IDPathway NameSource
hsa05206MicroRNAs in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000159217Odontogenesis2E-820195514
ENSG00000159217Odontogenesis7E-1623704328
ENSG00000159217Tooth Eruption2E-1423704328
ENSG00000159217Odontogenesis8E-720195514
ENSG00000159217Body Fat Distribution3E-826833246
ENSG00000159217Body Fat Distribution2E-826833246
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000159217rs1467209471749036943?Cognitive empathy28584286[0.088-0.223] unit decrease0.1555EFO_0009183
ENSG00000159217rs2002858751749013231?Cognitive empathy28584286[0.11-0.24] unit decrease0.1738EFO_0009183
ENSG00000159217rs283915891749004518ACognitive empathy28584286[0.087-0.221] unit decrease0.1541EFO_0009183
ENSG00000159217rs352976861749013226?Cognitive empathy28584286[0.099-0.227] unit decrease0.1631EFO_0009183
ENSG00000159217rs99069441749014058CBody fat percentage26833246[0.021-0.045] body fat % increase0.033EFO_0007800
ENSG00000159217rs99069441749014058CBody fat percentage26833246[0.023-0.047] body fat % increase0.035EFO_0007800
ENSG00000159217rs19949691749003069TPrimary tooth development (time to first tooth eruption)23704328[-0.02592-0.07992] unit decrease0.027GO_0044691
ENSG00000159217rs19949691749003069TPrimary tooth development (number of teeth)23704328[0.14-0.24] unit increase0.19GO_0042476
ENSG00000159217rs99069441749014058TIntelligence (MTAG)29326435[0.012-0.024] unit increase0.018285258EFO_0004337
ENSG00000159217rs110798491749013423TCognitive performance30038396[0.014-0.026] unit increase0.02EFO_0008354
ENSG00000159217rs110798491749013423TCognitive performance (MTAG)30038396[0.011-0.02] unit increase0.0156EFO_0008354
ENSG00000159217rs96745441749007349GPrimary tooth development (number of teeth)20195514GO_0042476
ENSG00000159217rs96745441749007349GPrimary tooth development (time to first tooth eruption)20195514GO_0042476
ENSG00000159217rs99069441749014058?General cognitive ability29844566z-score increase5.298EFO_0004337
ENSG00000159217rs110798491749013423TIntelligence29942086z-score increase5.591EFO_0004337
ENSG00000159217rs110798491749013423?Body mass index30595370EFO_0004340
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159217's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000159217IGF2BP15930.597ENSG00000090097PCBP48930.597
ENSG00000159217IGF2BP110073.846ENSG00000136231IGF2BP310072.899
ENSG00000159217IGF2BP15734.646ENSG00000197111PCBP29532.353
ENSG00000159217IGF2BP16033.333ENSG00000183570PCBP39233.333
ENSG00000159217IGF2BP19567.883ENSG00000073792IGF2BP29965.685
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000159217IGF2BP110099.307ENSAMEG00000005087IGF2BP19799.307Ailuropoda_melanoleuca
ENSG00000159217IGF2BP19094.626ENSAPLG00000012620IGF2BP110094.626Anas_platyrhynchos
ENSG00000159217IGF2BP110094.281ENSACAG00000006199IGF2BP110094.281Anolis_carolinensis
ENSG00000159217IGF2BP1100100.000ENSANAG00000022606IGF2BP1100100.000Aotus_nancymaae
ENSG00000159217IGF2BP1100100.000ENSBTAG00000011736IGF2BP110099.480Bos_taurus
ENSG00000159217IGF2BP1100100.000ENSCJAG00000007258IGF2BP1100100.000Callithrix_jacchus
ENSG00000159217IGF2BP1100100.000ENSCAFG00000016907IGF2BP110099.827Canis_familiaris
ENSG00000159217IGF2BP1100100.000ENSCAFG00020023369IGF2BP110099.827Canis_lupus_dingo
ENSG00000159217IGF2BP1100100.000ENSCHIG00000022316IGF2BP110099.480Capra_hircus
ENSG00000159217IGF2BP1100100.000ENSTSYG00000003912IGF2BP1100100.000Carlito_syrichta
ENSG00000159217IGF2BP17698.639ENSCAPG00000008985IGF2BP110098.639Cavia_aperea
ENSG00000159217IGF2BP19598.720ENSCPOG00000020174IGF2BP110098.720Cavia_porcellus
ENSG00000159217IGF2BP110096.707ENSCCAG00000031817IGF2BP110096.707Cebus_capucinus
ENSG00000159217IGF2BP1100100.000ENSCATG00000041707IGF2BP1100100.000Cercocebus_atys
ENSG00000159217IGF2BP110098.519ENSCLAG00000015853IGF2BP110098.440Chinchilla_lanigera
ENSG00000159217IGF2BP1100100.000ENSCSAG00000002487IGF2BP1100100.000Chlorocebus_sabaeus
ENSG00000159217IGF2BP18481.328ENSCHOG00000002349IGF2BP110081.328Choloepus_hoffmanni
ENSG00000159217IGF2BP19195.094ENSCPBG00000027315IGF2BP110084.402Chrysemys_picta_bellii
ENSG00000159217IGF2BP1100100.000ENSCANG00000032567IGF2BP1100100.000Colobus_angolensis_palliatus
ENSG00000159217IGF2BP17684.580ENSCGRG00001003571-10086.848Cricetulus_griseus_chok1gshd
ENSG00000159217IGF2BP1100100.000ENSCGRG00001000282-100100.000Cricetulus_griseus_chok1gshd
ENSG00000159217IGF2BP19089.423ENSCGRG00001006706-9785.688Cricetulus_griseus_chok1gshd
ENSG00000159217IGF2BP1100100.000ENSCGRG00000014555Igf2bp1100100.000Cricetulus_griseus_crigri
ENSG00000159217IGF2BP1100100.000ENSDNOG00000006801IGF2BP110096.187Dasypus_novemcinctus
ENSG00000159217IGF2BP110091.508ENSDORG00000014371Igf2bp110091.508Dipodomys_ordii
ENSG00000159217IGF2BP18791.837ENSETEG00000003370IGF2BP110079.923Echinops_telfairi
ENSG00000159217IGF2BP1100100.000ENSEASG00005000301IGF2BP110099.653Equus_asinus_asinus
ENSG00000159217IGF2BP1100100.000ENSECAG00000009723IGF2BP110099.653Equus_caballus
ENSG00000159217IGF2BP199100.000ENSEEUG00000010947IGF2BP110085.442Erinaceus_europaeus
ENSG00000159217IGF2BP1100100.000ENSFCAG00000002454IGF2BP1100100.000Felis_catus
ENSG00000159217IGF2BP18386.076ENSFALG00000011366IGF2BP17886.076Ficedula_albicollis
ENSG00000159217IGF2BP19793.939ENSFDAG00000017420IGF2BP110093.939Fukomys_damarensis
ENSG00000159217IGF2BP110094.281ENSGALG00000041204IGF2BP110094.281Gallus_gallus
ENSG00000159217IGF2BP17685.459ENSGAGG00000021663IGF2BP110085.459Gopherus_agassizii
ENSG00000159217IGF2BP1100100.000ENSGGOG00000008872IGF2BP1100100.000Gorilla_gorilla
ENSG00000159217IGF2BP110098.787ENSHGLG00000010492IGF2BP110098.787Heterocephalus_glaber_female
ENSG00000159217IGF2BP110098.787ENSHGLG00100006606IGF2BP110098.787Heterocephalus_glaber_male
ENSG00000159217IGF2BP1100100.000ENSSTOG00000010643IGF2BP110099.827Ictidomys_tridecemlineatus
ENSG00000159217IGF2BP1100100.000ENSJJAG00000002687Igf2bp110098.960Jaculus_jaculus
ENSG00000159217IGF2BP1100100.000ENSLAFG00000002048IGF2BP110099.653Loxodonta_africana
ENSG00000159217IGF2BP1100100.000ENSMFAG00000001613IGF2BP1100100.000Macaca_fascicularis
ENSG00000159217IGF2BP1100100.000ENSMMUG00000011533IGF2BP1100100.000Macaca_mulatta
ENSG00000159217IGF2BP1100100.000ENSMNEG00000033825IGF2BP1100100.000Macaca_nemestrina
ENSG00000159217IGF2BP1100100.000ENSMLEG00000026086IGF2BP1100100.000Mandrillus_leucophaeus
ENSG00000159217IGF2BP18194.839ENSMGAG00000002497IGF2BP110094.839Meleagris_gallopavo
ENSG00000159217IGF2BP17780.405ENSMICG00000043511-9980.405Microcebus_murinus
ENSG00000159217IGF2BP110099.543ENSMICG00000013324-10099.543Microcebus_murinus
ENSG00000159217IGF2BP1100100.000ENSMOCG00000010232Igf2bp1100100.000Microtus_ochrogaster
ENSG00000159217IGF2BP110097.574ENSMODG00000012268IGF2BP110097.574Monodelphis_domestica
ENSG00000159217IGF2BP1100100.000MGP_CAROLIEiJ_G0017016Igf2bp110099.307Mus_caroli
ENSG00000159217IGF2BP1100100.000ENSMUSG00000013415Igf2bp110099.307Mus_musculus
ENSG00000159217IGF2BP1100100.000MGP_SPRETEiJ_G0017862Igf2bp110099.307Mus_spretus
ENSG00000159217IGF2BP18794.862ENSMPUG00000015358IGF2BP110094.862Mustela_putorius_furo
ENSG00000159217IGF2BP18373.750ENSMLUG00000023642-10073.750Myotis_lucifugus
ENSG00000159217IGF2BP17197.052ENSMLUG00000016891-10097.052Myotis_lucifugus
ENSG00000159217IGF2BP1100100.000ENSNGAG00000015679Igf2bp1100100.000Nannospalax_galili
ENSG00000159217IGF2BP1100100.000ENSNLEG00000002786IGF2BP1100100.000Nomascus_leucogenys
ENSG00000159217IGF2BP18898.936ENSMEUG00000002152-8498.936Notamacropus_eugenii
ENSG00000159217IGF2BP19094.595ENSOPRG00000010207IGF2BP110094.595Ochotona_princeps
ENSG00000159217IGF2BP110099.307ENSODEG00000016991-10099.307Octodon_degus
ENSG00000159217IGF2BP18679.158ENSODEG00000014533-9279.158Octodon_degus
ENSG00000159217IGF2BP151100.000ENSOANG00000014859-10083.196Ornithorhynchus_anatinus
ENSG00000159217IGF2BP19999.474ENSOCUG00000004411IGF2BP110099.474Oryctolagus_cuniculus
ENSG00000159217IGF2BP110099.653ENSOGAG00000001270IGF2BP110099.653Otolemur_garnettii
ENSG00000159217IGF2BP1100100.000ENSOARG00000006509IGF2BP110099.133Ovis_aries
ENSG00000159217IGF2BP110099.827ENSPPAG00000040224IGF2BP110099.827Pan_paniscus
ENSG00000159217IGF2BP1100100.000ENSPPRG00000008067IGF2BP1100100.000Panthera_pardus
ENSG00000159217IGF2BP1100100.000ENSPTIG00000013291IGF2BP1100100.000Panthera_tigris_altaica
ENSG00000159217IGF2BP110099.827ENSPTRG00000009368IGF2BP110099.827Pan_troglodytes
ENSG00000159217IGF2BP1100100.000ENSPANG00000022833IGF2BP1100100.000Papio_anubis
ENSG00000159217IGF2BP18681.873ENSPSIG00000005175IGF2BP110081.873Pelodiscus_sinensis
ENSG00000159217IGF2BP1100100.000ENSPEMG00000021974Igf2bp110099.653Peromyscus_maniculatus_bairdii
ENSG00000159217IGF2BP110099.259ENSPCIG00000013111IGF2BP110097.574Phascolarctos_cinereus
ENSG00000159217IGF2BP1100100.000ENSPPYG00000008913IGF2BP1100100.000Pongo_abelii
ENSG00000159217IGF2BP110090.988ENSPCAG00000016601IGF2BP110090.988Procavia_capensis
ENSG00000159217IGF2BP110099.772ENSPCOG00000006475IGF2BP110099.772Propithecus_coquereli
ENSG00000159217IGF2BP1100100.000ENSPVAG00000001718IGF2BP185100.000Pteropus_vampyrus
ENSG00000159217IGF2BP1100100.000ENSRNOG00000006122Igf2bp110099.653Rattus_norvegicus
ENSG00000159217IGF2BP1100100.000ENSRBIG00000035739IGF2BP1100100.000Rhinopithecus_bieti
ENSG00000159217IGF2BP1100100.000ENSRROG00000039581IGF2BP1100100.000Rhinopithecus_roxellana
ENSG00000159217IGF2BP110099.827ENSSBOG00000020973IGF2BP110099.827Saimiri_boliviensis_boliviensis
ENSG00000159217IGF2BP110097.400ENSSHAG00000014259IGF2BP110097.400Sarcophilus_harrisii
ENSG00000159217IGF2BP18690.789ENSSARG00000013201-7390.789Sorex_araneus
ENSG00000159217IGF2BP110092.042ENSSPUG00000006526IGF2BP110092.042Sphenodon_punctatus
ENSG00000159217IGF2BP19873.913ENSSSCG00000001827-10068.166Sus_scrofa
ENSG00000159217IGF2BP1100100.000ENSSSCG00000023128-10099.653Sus_scrofa
ENSG00000159217IGF2BP188100.000ENSTBEG00000004254IGF2BP110080.416Tupaia_belangeri
ENSG00000159217IGF2BP110096.360ENSTTRG00000007197IGF2BP110096.360Tursiops_truncatus
ENSG00000159217IGF2BP1100100.000ENSUAMG00000023269IGF2BP110099.827Ursus_americanus
ENSG00000159217IGF2BP110099.653ENSUMAG00000015682IGF2BP110099.653Ursus_maritimus
ENSG00000159217IGF2BP171100.000ENSVPAG00000007657IGF2BP18388.496Vicugna_pacos
ENSG00000159217IGF2BP1100100.000ENSVVUG00000003451IGF2BP110099.827Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003729mRNA binding17101699.17289661.IDAFunction
GO:0003730mRNA 3'-UTR binding20080952.IDAFunction
GO:0005515protein binding17289661.17932509.19029303.20543829.24965446.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm9891060.17289661.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0010494cytoplasmic stress granule17101699.IDAComponent
GO:0010610regulation of mRNA stability involved in response to stress17101699.IMPProcess
GO:0017148negative regulation of translation9891060.IDAProcess
GO:0022013pallium cell proliferation in forebrain-IEAProcess
GO:0030027lamellipodium-IEAComponent
GO:0030175filopodium-IEAComponent
GO:0030426growth cone-IEAComponent
GO:0042035regulation of cytokine biosynthetic process9891060.ICProcess
GO:0043197dendritic spine-IEAComponent
GO:0043488regulation of mRNA stability-TASProcess
GO:0045182translation regulator activity9891060.IDAFunction
GO:0048027mRNA 5'-UTR binding9891060.IDAFunction
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0051028mRNA transport-IEAProcess
GO:0070934CRD-mediated mRNA stabilization19029303.IDAProcess
GO:0070937CRD-mediated mRNA stability complex19029303.IDAComponent
GO:0097150neuronal stem cell population maintenance-IEAProcess
GO:1990904ribonucleoprotein complex17289661.IDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us