EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15748890	The actin cytoskeleton-associated protein zyxin acts as a tumor suppressor in Ewing tumor cells.	Exp Cell Res	2005 Apr 1	Amsellem V	-
23321499	Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.	Cancer Lett	2013 May 1	Youn H	doi: 10.1016/j.canlet.2012.12.019
22778267	Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.	J Biol Chem	2012 Sep 7	Mise N	doi: 10.1074/jbc.M112.357624
29967145	Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.	Proc Natl Acad Sci U S A	2018 Jul 17	Zhou J	doi: 10.1073/pnas.1800621115

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr7	143390751	3'UTR	novel		0.29
ACC	chr7	143390641	Missense_Mutation	rs747069930	V560M	0.1
BLCA	chr7	143382402	Silent	NA	P121P	0.47
BLCA	chr7	143388540	Missense_Mutation	rs576382219	R399H	0.42
BLCA	chr7	143381609	Missense_Mutation	rs748403980	S13L	0.4
BRCA	chr7	143382273	Silent	novel	L78L	0.6
BRCA	chr7	143383001	Silent	NA	V234V	0.19
BRCA	chr7	143388800	Missense_Mutation	NA	P450S	0.57
BRCA	chr7	143382591	Splice_Site	novel	X137_splice	0.03
BRCA	chr7	143382592	Splice_Site	novel	X137_splice	0.03
BRCA	chr7	143388844	Silent	rs145663530	H464H	0.22
CESC	chr7	143382651	Missense_Mutation	novel	D156V	0.07
CESC	chr7	143388540	Missense_Mutation	rs576382219	R399H	0.33
CESC	chr7	143383101	Missense_Mutation	rs758266725	P268A	0.29
CESC	chr7	143382978	Nonsense_Mutation	NA	Q227*	0.46
CHOL	chr7	143383114	Missense_Mutation	novel	K272T	0.36
CHOL	chr7	143382308	Missense_Mutation	NA	G90E	0.15
COAD	chr7	143389927	Nonsense_Mutation	rs750192633	R522*	0.08
COAD	chr7	143389935	Silent	novel	V524V	0.46
COAD	chr7	143383036	Missense_Mutation	NA	S246Y	0.33
COAD	chr7	143382359	Missense_Mutation	NA	A107V	0.23
COAD	chr7	143389878	Silent	rs142687371	S505S	0.28
COAD	chr7	143388560	Missense_Mutation	NA	H406Y	0.19
ESCA	chr7	143383081	Missense_Mutation	novel	A261G	0.37
GBM	chr7	143388871	Silent	rs146983863	C473C	0.2
GBM	chr7	143383159	Missense_Mutation	NA	G287E	0.33
GBM	chr7	143383206	Missense_Mutation	NA	S303P	0.29
HNSC	chr7	143382355	Missense_Mutation	novel	P106T	0.11
HNSC	chr7	143388891	Missense_Mutation	novel	T480I	0.14
HNSC	chr7	143388892	Silent	rs142288548	T480T	0.13
HNSC	chr7	143382650	Missense_Mutation	novel	D156N	0.42
KIRC	chr7	143382668	Missense_Mutation	rs777343615	D162N	0.16
KIRP	chr7	143383199	Silent	rs140819301	E300E	0.1
LAML	chr7	143389924	Missense_Mutation	novel	V521M	0.05
LGG	chr7	143382600	In_Frame_Del	novel	K140del	0.2
LIHC	chr7	143383075	Missense_Mutation	novel	S259Y	0.56
LUAD	chr7	143382618	Missense_Mutation	novel	D145V	0.09
LUAD	chr7	143382684	Missense_Mutation	NA	R167L	0.3
LUAD	chr7	143388643	Silent	rs374951395	C433C	0.15
LUAD	chr7	143382898	Missense_Mutation	rs150223874	W200L	0.14
LUAD	chr7	143388559	Silent	novel	F405F	0.13
LUAD	chr7	143381719	Missense_Mutation	NA	P50S	0.2
LUSC	chr7	143389888	Missense_Mutation	novel	E509Q	0.1
LUSC	chr7	143382369	Silent	NA	E110E	0.32
LUSC	chr7	143383197	Missense_Mutation	rs368759415	E300K	0.09
LUSC	chr7	143388651	Missense_Mutation	novel	C436S	0.3
LUSC	chr7	143388803	Missense_Mutation	NA	I451V	0.16
LUSC	chr7	143382436	Missense_Mutation	novel	P133S	0.13
LUSC	chr7	143383195	Missense_Mutation	novel	P299L	0.27
OV	chr7	143382887	Silent	novel	P196P	0.14
OV	chr7	143382831	Missense_Mutation	novel	A178T	0.12
OV	chr7	143382938	Silent	rs543840726	P213P	0.06
PAAD	chr7	143382367	Nonsense_Mutation	novel	E110*	0.08
PAAD	chr7	143382375	Silent	novel	E112E	0.06
PRAD	chr7	143388526	Silent	novel	A394A	0.51
READ	chr7	143389879	Missense_Mutation	rs569088357	V506I	0.32
READ	chr7	143383111	Missense_Mutation	novel	P271H	0.33
READ	chr7	143382837	Missense_Mutation	novel	P180T	0.28
READ	chr7	143388871	Silent	rs146983863	C473C	0.16
SARC	chr7	143390553	Intron	novel		0.18
SKCM	chr7	143383196	Silent	rs766453615	P299P	0.46
SKCM	chr7	143382910	Missense_Mutation	rs768328401	S204F	0.54
SKCM	chr7	143383291	Missense_Mutation	NA	P331L	0.36
SKCM	chr7	143388913	Silent	novel	A487A	0.37
SKCM	chr7	143382871	Missense_Mutation	NA	A191V	0.72
SKCM	chr7	143381684	Missense_Mutation	novel	P38L	0.32
SKCM	chr7	143381685	Silent	rs554528272	P38P	0.33
SKCM	chr7	143382318	Silent	NA	F93F	0.45
SKCM	chr7	143382343	Missense_Mutation	NA	E102K	0.46
SKCM	chr7	143388313	Missense_Mutation	NA	P373L	0.17
SKCM	chr7	143382428	Missense_Mutation	novel	P130L	0.15
SKCM	chr7	143382429	Silent	novel	P130P	0.15
SKCM	chr7	143388901	Silent	rs574219835	I483I	0.48
SKCM	chr7	143383116	Missense_Mutation	NA	F273V	0.05
SKCM	chr7	143389867	Missense_Mutation	NA	P502S	0.2
SKCM	chr7	143389913	Missense_Mutation	rs773528813	R517Q	0.28
SKCM	chr7	143388315	Nonsense_Mutation	novel	Q374*	0.27
STAD	chr7	143388540	Missense_Mutation	rs576382219	R399H	0.14
STAD	chr7	143388633	Missense_Mutation	NA	A430E	0.33
STAD	chr7	143389934	Missense_Mutation	NA	V524A	0.18
STAD	chr7	143382882	Missense_Mutation	NA	A195T	0.25
STAD	chr7	143382934	Missense_Mutation	NA	V212A	0.16
STAD	chr7	143382844	Missense_Mutation	NA	S182N	0.28
STAD	chr7	143389975	Missense_Mutation	NA	E538K	0.29
STAD	chr7	143388526	Silent	novel	A394A	0.53
UCEC	chr7	143388339	Missense_Mutation	NA	E382K	0.5
UCEC	chr7	143382664	Missense_Mutation	novel	K160N	0.28
UCEC	chr7	143381668	Missense_Mutation	novel	K33E	0.22
UCEC	chr7	143388308	Silent	novel	E371E	0.35
UCEC	chr7	143389946	Missense_Mutation	novel	K528T	0.25
UCEC	chr7	143383071	Missense_Mutation	NA	S258A	0.17
UCEC	chr7	143390986	3'UTR	novel		0.29
UCEC	chr7	143388936	Missense_Mutation	novel	D495G	0.33
UCEC	chr7	143382617	Missense_Mutation	NA	D145N	0.26
UCEC	chr7	143388781	Missense_Mutation	rs777931036	K443N	0.1
UCEC	chr7	143390651	Missense_Mutation	rs149835123	R563Q	0.27
UCEC	chr7	143388861	Missense_Mutation	rs751775395	C470Y	0.22
UCEC	chr7	143389936	Missense_Mutation	NA	A525T	0.44
UCEC	chr7	143382402	Silent	NA	P121P	0.5
UCEC	chr7	143391088	3'UTR	novel		0.38
UCEC	chr7	143389857	Splice_Region	novel	K498K	0.27
UCEC	chr7	143391052	3'UTR	novel		0.21
UCEC	chr7	143388306	Missense_Mutation	novel	E371K	0.45
UCEC	chr7	143388592	Silent	rs541672435	A416A	0.37
UCEC	chr7	143390822	3'UTR	novel		0.23
UCEC	chr7	143388245	Silent	novel	P350P	0.55
UCEC	chr7	143383197	Missense_Mutation	rs368759415	E300K	0.36
UCEC	chr7	143388872	Missense_Mutation	rs781295880	A474T	0.35
UCEC	chr7	143390584	Missense_Mutation	rs756852682	G541R	0.07
UCEC	chr7	143382247	Splice_Site	novel	X70_splice	0.17
UCEC	chr7	143382856	Missense_Mutation	novel	S186N	0.37
UCEC	chr7	143382286	Missense_Mutation	novel	D83N	0.52
UCEC	chr7	143388339	Nonsense_Mutation	NA	E382*	0.3
UCEC	chr7	143383197	Missense_Mutation	rs368759415	E300K	0.19
UCEC	chr7	143382354	Silent	NA	P105P	0.24
UCEC	chr7	143382986	Silent	rs747897982	Q229Q	0.27
UCEC	chr7	143383315	Frame_Shift_Del	novel	*N340Tfs12**	0.47
UCEC	chr7	143390584	Missense_Mutation	rs756852682	G541R	0.31
UCEC	chr7	143383077	Missense_Mutation	NA	P260T	0.24
UCEC	chr7	143391016	3'UTR	novel		0.5
UCS	chr7	143389923	Silent	novel	T520T	0.48

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0667	0.12261
CESC	DEL	0.1797	0.0016147
DLBC	DEL	0.0833	0.03486
KIRC	AMP	0.286	0.075418
LAML	DEL	0.1257	3.4101e-05
LGG	AMP	0.3119	1.5525e-07
LIHC	DEL	0.0811	0.24831
PAAD	DEL	0.0598	0.049388
TGCT	DEL	0.0667	0.11738
THCA	DEL	0	0.27619
UCEC	DEL	0.0928	0.0001859
UCS	DEL	0.3036	0.10142

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00052	Kaplan-Meier Survival Analysis
SARC	0.0051	Kaplan-Meier Survival Analysis
MESO	0.0021	Kaplan-Meier Survival Analysis
SKCM	0.015	Kaplan-Meier Survival Analysis
LUSC	0.0062	Kaplan-Meier Survival Analysis
BRCA	0.005	Kaplan-Meier Survival Analysis
ESCA	0.015	Kaplan-Meier Survival Analysis
COAD	0.048	Kaplan-Meier Survival Analysis
LAML	0.0043	Kaplan-Meier Survival Analysis
LIHC	0.0065	Kaplan-Meier Survival Analysis
CHOL	0.047	Kaplan-Meier Survival Analysis
LUAD	0.045	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000159840 (Gene tree)
Gene ID: 7791
Gene Symbol: ZYX
Alias: N
Full Name: zyxin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 12,783 bases
Position: chr7:143,378,329-143,391,111
Accession: 13200
RBP type: non-canonical RBP
Summary: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11950970	The rice mutant esp2 greatly accumulates the glutelin precursor and deletes the protein disulfide isomerase.	Plant Physiol	2002 Apr	Takemoto Y	-
22395610	Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.	Nat Commun	2012 Mar 6	Fraley SI	doi: 10.1038/ncomms1711.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497119	ZYX-210	560	-	-	- (aa)	-	-
ENST00000436448	ZYX-204	632	-	ENSP00000411230	176 (aa)	-	H7C3D3
ENST00000322764	ZYX-201	2493	XM_017012587	ENSP00000324422	572 (aa)	XP_016868076	Q15942
ENST00000446634	ZYX-205	926	-	ENSP00000403714	171 (aa)	-	C9JJK5
ENST00000457235	ZYX-207	703	-	ENSP00000400537	164 (aa)	-	C9IZ41
ENST00000477373	ZYX-209	504	-	-	- (aa)	-	-
ENST00000449630	ZYX-206	533	-	ENSP00000413467	177 (aa)	-	H7C3R3
ENST00000468083	ZYX-208	1146	-	-	- (aa)	-	-
ENST00000354434	ZYX-202	2050	XM_011516569	ENSP00000346417	540 (aa)	-	H0Y2Y8
ENST00000392910	ZYX-203	2123	-	ENSP00000376642	415 (aa)	-	Q15942

Gene Model

Click here to download ENSG00000159840's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04510	Focal adhesion	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000159840	rs11772895	7	143384849	C	White blood cell count (basophil)	27863252	[0.015-0.031] unit increase	0.02311239	EFO_0005090

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000159840's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000159840	ZYX	91	46.835	ENSG00000087077	TRIP6	91	40.609	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001725	stress fiber	18297730.24036928.	IDA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	10831611.22665060.23840749.25416956.26871637.	IPI	Function
GO:0005634	nucleus	24036928.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005913	cell-cell adherens junction	8940160.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	12417594.18297730.	IDA	Component
GO:0007160	cell-matrix adhesion	24036928.	IC	Process
GO:0007179	transforming growth factor beta receptor signaling pathway	24036928.	IMP	Process
GO:0007229	integrin-mediated signaling pathway	24036928.	IMP	Process
GO:0007267	cell-cell signaling	8940160.	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0043149	stress fiber assembly	24036928.	IMP	Process
GO:0045335	phagocytic vesicle	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0050727	regulation of inflammatory response	-	IEA	Process
GO:0071346	cellular response to interferon-gamma	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.