EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22664726	ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.	Mitochondrion	2012 Jul	Merle N	doi: 10.1016/j.mito.2012.05.005

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	1487900	Missense_Mutation	rs199705339	R418W	0.15
BLCA	chr1	1485815	Missense_Mutation	novel	V314L	0.25
BLCA	chr1	1490203	Intron	NA		0.25
BLCA	chr1	1490253	Splice_Region	novel		0.48
BLCA	chr1	1485784	Splice_Region	novel	V303V	0.15
BLCA	chr1	1482178	Silent	NA	E185E	0.13
BLCA	chr1	1486661	Missense_Mutation	rs139682140	R403W	0.21
BLCA	chr1	1487900	Missense_Mutation	rs199705339	R418W	0.15
BLCA	chr1	1485171	Missense_Mutation	rs781172015	Q302H	0.32
BRCA	chr1	1490662	Silent	rs754972620	V535V	0.87
BRCA	chr1	1495961	3'UTR	novel		0.5
BRCA	chr1	1487900	Missense_Mutation	rs199705339	R418W	0.38
BRCA	chr1	1495857	3'UTR	novel		0.29
BRCA	chr1	1482563	Missense_Mutation	novel	F233L	0.1
CESC	chr1	1490387	Missense_Mutation	NA	D490N	0.15
CESC	chr1	1490256	Splice_Site	NA	X446_splice	0.37
CESC	chr1	1485799	Silent	NA	L308L	0.2
CESC	chr1	1495724	Missense_Mutation	novel	W618C	0.1
CESC	chr1	1482651	Intron	NA		0.26
CESC	chr1	1482653	Intron	rs376802044		0.17
COAD	chr1	1485803	Nonsense_Mutation	rs751720138	R310*	0.35
COAD	chr1	1495782	Missense_Mutation	rs752824611	R638W	0.26
COAD	chr1	1495792	Frame_Shift_Ins	rs577360633	*G644Rfs10**	0.3
COAD	chr1	1486662	Missense_Mutation	rs770117658	R403Q	0.41
COAD	chr1	1485072	Silent	rs781603814	A269A	0.43
COAD	chr1	1490590	Silent	rs530433509	Y511Y	0.27
COAD	chr1	1490169	Intron	novel		0.23
COAD	chr1	1495522	Missense_Mutation	novel	E551V	0.16
COAD	chr1	1486667	Missense_Mutation	rs750391230	G405S	0.21
COAD	chr1	1482248	Missense_Mutation	rs777121713	E209K	0.25
COAD	chr1	1485792	Missense_Mutation	rs367992193	R306Q	0.67
ESCA	chr1	1477290	Silent	novel	A74A	0.54
ESCA	chr1	1482150	Missense_Mutation	rs765374341	R176Q	0.27
GBM	chr1	1482172	Missense_Mutation	rs748908531	K183N	0.27
GBM	chr1	1477320	Silent	rs142559400	T84T	0.37
HNSC	chr1	1482594	Missense_Mutation	rs3979437	R244W	0.15
HNSC	chr1	1495490	Silent	rs757100078	T540T	0.58
HNSC	chr1	1482211	Silent	rs757834254	R196R	0.5
HNSC	chr1	1485789	Missense_Mutation	rs138300243	R305Q	0.31
KICH	chr1	1490423	Missense_Mutation	rs371526893	R502W	0.72
KIRP	chr1	1490669	Nonsense_Mutation	novel	Q538*	0.39
KIRP	chr1	1490191	Intron	novel		0.18
LGG	chr1	1489240	Missense_Mutation	rs371673051	A435T	0.34
LGG	chr1	1490195	Intron	novel		0.44
LGG	chr1	1486153	Missense_Mutation	NA	R336K	0.33
LGG	chr1	1495912	3'UTR	novel		0.18
LIHC	chr1	1490565	Missense_Mutation	novel	R503L	0.43
LUAD	chr1	1477272	Splice_Site	NA	X69_splice	0.57
LUAD	chr1	1490184	Intron	novel		0.13
LUAD	chr1	1485097	Missense_Mutation	rs376567838	R278W	0.22
LUAD	chr1	1477302	Silent	NA	A78A	0.79
LUAD	chr1	1495798	Missense_Mutation	rs148302536	P643L	0.08
LUAD	chr1	1479051	Missense_Mutation	novel	R129S	0.39
LUAD	chr1	1486572	Missense_Mutation	NA	Y373F	0.08
LUAD	chr1	1482579	Missense_Mutation	NA	A239S	0.69
LUAD	chr1	1477275	Splice_Region	novel	R69R	0.3
LUAD	chr1	1485169	Nonsense_Mutation	novel	Q302*	0.08
LUAD	chr1	1490391	Missense_Mutation	novel	N491I	0.2
LUSC	chr1	1495782	Missense_Mutation	rs752824611	R638W	0.12
LUSC	chr1	1490283	Frame_Shift_Ins	novel	*R466Lfs14**	0.23
LUSC	chr1	1495748	Silent	rs533689685	G626G	0.17
LUSC	chr1	1490332	Silent	novel	V471V	0.44
LUSC	chr1	1490250	Splice_Region	novel		0.25
LUSC	chr1	1477294	Missense_Mutation	novel	N76Y	0.32
OV	chr1	1495517	Silent	novel	L549L	0.43
PCPG	chr1	1486553	Missense_Mutation	novel	L367M	0.15
PRAD	chr1	1495823	3'UTR	novel		0.23
PRAD	chr1	1490182	Intron	novel		0.33
PRAD	chr1	1486588	Silent	rs772706411	G378G	0.2
READ	chr1	1477319	Missense_Mutation	rs144497634	T84M	0.26
READ	chr1	1495535	Silent	rs112543187	D555D	0.36
READ	chr1	1486170	Missense_Mutation	NA	R342W	0.16
READ	chr1	1485786	Missense_Mutation	novel	S304N	0.41
READ	chr1	1482256	Silent	NA	I211I	0.34
SARC	chr1	1482220	Silent	rs544884479	A199A	0.51
SARC	chr1	1477289	Missense_Mutation	rs148312059	A74V	0.38
SARC	chr1	1490378	Silent	novel	L487L	0.49
SKCM	chr1	1482576	Missense_Mutation	rs757344083	R238C	0.29
SKCM	chr1	1485131	Missense_Mutation	novel	S289F	0.33
SKCM	chr1	1486191	Silent	novel	L349L	0.28
SKCM	chr1	1495841	3'UTR	novel		0.23
SKCM	chr1	1495600	Missense_Mutation	NA	P577L	0.68
SKCM	chr1	1482297	Missense_Mutation	novel	S225F	0.32
SKCM	chr1	1482298	Silent	novel	S225S	0.32
SKCM	chr1	1495795	Missense_Mutation	NA	P642L	0.86
SKCM	chr1	1490374	Silent	novel	V485V	0.58
SKCM	chr1	1490338	Silent	rs201433699	F473F	0.38
SKCM	chr1	1490338	Silent	rs201433699	F473F	0.47
SKCM	chr1	1482241	Silent	NA	I206I	0.15
SKCM	chr1	1486190	Silent	NA	I348I	0.48
SKCM	chr1	1480907	Missense_Mutation	rs145500839	S162F	0.21
SKCM	chr1	1482285	Missense_Mutation	NA	T221I	0.26
STAD	chr1	1485791	Missense_Mutation	rs759930254	R306W	0.58
STAD	chr1	1489240	Missense_Mutation	rs371673051	A435T	0.34
STAD	chr1	1489239	Silent	rs770357971	N434N	0.21
STAD	chr1	1487890	Silent	rs759328778	D414D	0.14
STAD	chr1	1486183	Missense_Mutation	NA	R346M	0.18
STAD	chr1	1482245	Missense_Mutation	novel	R208C	0.12
STAD	chr1	1480876	Missense_Mutation	NA	N152D	0.14
STAD	chr1	1486177	Missense_Mutation	rs368191921	L344P	0.07
TGCT	chr1	1495846	3'UTR	rs541175302		0.19
TGCT	chr1	1495805	Missense_Mutation	novel	H645Q	0.15
UCEC	chr1	1490565	Missense_Mutation	NA	R503H	0.58
UCEC	chr1	1480884	Missense_Mutation	NA	E154D	0.36
UCEC	chr1	1480884	Missense_Mutation	NA	E154D	0.28
UCEC	chr1	1486550	Missense_Mutation	rs757157792	A366T	0.14
UCEC	chr1	1495883	3'UTR	rs564244148		0.2
UCEC	chr1	1489228	Missense_Mutation	novel	A431S	0.4
UCEC	chr1	1490211	Intron	novel		0.23
UCEC	chr1	1486215	Missense_Mutation	novel	G357R	0.33
UCEC	chr1	1495671	Missense_Mutation	novel	D601N	0.41
UCEC	chr1	1482609	Missense_Mutation	novel	A249T	0.32
UCEC	chr1	1489226	Missense_Mutation	novel	R430I	0.21
UCEC	chr1	1482212	Missense_Mutation	rs778410435	A197T	0.36
UCEC	chr1	1486579	Silent	NA	I375I	0.29
UCEC	chr1	1482576	Missense_Mutation	rs757344083	R238C	0.6
UCEC	chr1	1485128	Missense_Mutation	rs746903013	T288M	0.18
UCEC	chr1	1489259	Missense_Mutation	novel	G441D	0.06
UCEC	chr1	1495883	3'UTR	rs564244148		0.24
UCEC	chr1	1495592	Silent	rs756775187	A574A	0.29
UCEC	chr1	1478690	Missense_Mutation	rs200050752	A110V	0.34
UCEC	chr1	1485081	Silent	novel	G272G	0.18
UCEC	chr1	1495566	Nonsense_Mutation	rs745960753	R566*	0.3
UCEC	chr1	1489241	Missense_Mutation	novel	A435V	0.53
UCEC	chr1	1490347	Silent	rs763121998	P476P	0.41
UCEC	chr1	1490365	Missense_Mutation	novel	E482D	0.47
UCEC	chr1	1478736	Silent	novel	Q125Q	0.3
UCEC	chr1	1480866	Splice_Site	novel	X149_splice	0.33
UCEC	chr1	1486328	Intron	novel		0.37
UCEC	chr1	1487870	Missense_Mutation	novel	L408F	0.26
UCEC	chr1	1486134	Missense_Mutation	rs776507286	D330N	0.29
UCEC	chr1	1482272	Missense_Mutation	rs768804040	E217K	0.43
UCEC	chr1	1490257	Splice_Region	novel	K446K	0.55
UCEC	chr1	1482658	Intron	novel		0.06
UCEC	chr1	1487876	Missense_Mutation	rs148709813	M410V	0.09
UCEC	chr1	1478601	Intron	novel		0.28
UCEC	chr1	1482576	Missense_Mutation	novel	R238S	0.39
UCEC	chr1	1486170	Missense_Mutation	NA	R342W	0.25
UCEC	chr1	1482543	Splice_Site	NA	X227_splice	0.49
UCEC	chr1	1486163	Missense_Mutation	NA	K339N	0.3
UCEC	chr1	1485060	Missense_Mutation	novel	K265N	0.56
UCEC	chr1	1490285	Missense_Mutation	novel	P456S	0.76

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1153	0.00029523
DLBC	DEL	0.1875	0.011841
HNSC	DEL	0.1418	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.184	1.462e-09
LIHC	DEL	0.4027	1.1606e-33
LUAD	DEL	0.1357	0.0024765
LUSC	DEL	0.3473	2.5882e-07
MESO	DEL	0.3448	2.434e-07
SARC	DEL	0.2412	8.425e-11
SKCM	DEL	0.1689	5.1876e-09
TGCT	DEL	0.1867	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
STAD	0.015	Kaplan-Meier Survival Analysis
SARC	0.0093	Kaplan-Meier Survival Analysis
MESO	0.022	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
PRAD	0.041	Kaplan-Meier Survival Analysis
COAD	0.048	Kaplan-Meier Survival Analysis
PCPG	0.024	Kaplan-Meier Survival Analysis
LIHC	0.00017	Kaplan-Meier Survival Analysis
DLBC	0.03	Kaplan-Meier Survival Analysis
LGG	0.0026	Kaplan-Meier Survival Analysis
OV	0.031	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000160072 (Gene tree)
Gene ID: 83858
Gene Symbol: ATAD3B
Alias: TOB3|KIAA1273
Full Name: ATPase family AAA domain containing 3B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 37,748 bases
Position: chr1:1,471,732-1,509,479
Accession: 24007
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474481	ATAD3B-204	3367	-	-	- (aa)	-	-
ENST00000485748	ATAD3B-205	3233	-	-	- (aa)	-	-
ENST00000472194	ATAD3B-203	4314	-	-	- (aa)	-	-
ENST00000378736	ATAD3B-202	414	-	-	- (aa)	-	-
ENST00000308647	ATAD3B-201	2448	XM_005244806	ENSP00000311766	648 (aa)	XP_005244863	Q5T9A4

Gene Model

Click here to download ENSG00000160072's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160072's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	IEA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0007005	mitochondrion organization	21873635.	IBA	Process
GO:0008270	zinc ion binding	21873635.	IBA	Function
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0101003	ficolin-1-rich granule membrane	-	TAS	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.