EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	144440144	Missense_Mutation	rs189270359	E453K	0.26
BLCA	chr8	144434077	Silent	NA	T1096T	0.63
BLCA	chr8	144438497	Missense_Mutation	novel	R543S	0.2
BLCA	chr8	144442381	Missense_Mutation	rs547875792	A204T	0.1
BLCA	chr8	144442362	In_Frame_Del	novel	F202_T210del	0.52
BLCA	chr8	144442056	Missense_Mutation	novel	I282M	0.25
BLCA	chr8	144432423	Silent	rs374357745	N1199N	0.14
BLCA	chr8	144435924	Missense_Mutation	NA	E837K	0.33
BLCA	chr8	144440745	Silent	novel	L379L	0.24
BLCA	chr8	144434100	Missense_Mutation	NA	E1089K	0.19
BLCA	chr8	144442274	Silent	novel	F239F	0.27
BRCA	chr8	144435472	Splice_Site	novel	X951_splice	0.29
BRCA	chr8	144438757	Intron	novel		0.08
BRCA	chr8	144432423	Silent	rs374357745	N1199N	0.27
BRCA	chr8	144437064	Missense_Mutation	novel	W563C	0.11
BRCA	chr8	144436973	Intron	novel		0.22
BRCA	chr8	144440066	Missense_Mutation	NA	E479K	0.2
BRCA	chr8	144443273	Missense_Mutation	novel	E105Q	0.48
CESC	chr8	144432346	Missense_Mutation	NA	S1225F	0.13
CESC	chr8	144435767	Missense_Mutation	rs529030862	A889V	0.42
CESC	chr8	144434018	Missense_Mutation	rs782170769	R1116H	0.24
CESC	chr8	144436145	Missense_Mutation	rs776417303	S763L	0.56
CESC	chr8	144436619	Frame_Shift_Ins	novel	*E652Kfs39**	0.09
CESC	chr8	144433697	Frame_Shift_Ins	novel	*L1152Pfs25**	0.09
CESC	chr8	144434221	Silent	rs569596561	S1048S	0.13
CESC	chr8	144434161	Silent	novel	L1068L	0.1
CESC	chr8	144434031	Missense_Mutation	NA	P1112T	0.35
CESC	chr8	144434123	Missense_Mutation	rs782604369	R1081Q	0.35
CESC	chr8	144440108	Missense_Mutation	NA	E465K	0.43
COAD	chr8	144435346	Intron	novel		0.18
COAD	chr8	144443905	Missense_Mutation	novel	E81K	0.24
COAD	chr8	144434254	Silent	rs142494135	A1037A	0.22
COAD	chr8	144442767	Missense_Mutation	novel	R163H	0.07
COAD	chr8	144443136	Splice_Site	novel	X150_splice	0.43
COAD	chr8	144442768	Missense_Mutation	NA	R163C	0.35
COAD	chr8	144434162	Missense_Mutation	NA	L1068Q	0.16
COAD	chr8	144435093	Missense_Mutation	novel	R977M	0.05
COAD	chr8	144433660	Missense_Mutation	rs781935858	R1163C	0.11
COAD	chr8	144442380	Missense_Mutation	NA	A204V	0.31
COAD	chr8	144433659	Missense_Mutation	rs782299928	R1163H	0.34
COAD	chr8	144442103	Missense_Mutation	novel	K267E	0.09
ESCA	chr8	144435539	Silent	novel	P929P	0.16
ESCA	chr8	144440131	Missense_Mutation	novel	R457L	0.1
ESCA	chr8	144436978	Intron	novel		0.17
GBM	chr8	144441000	Missense_Mutation	novel	D326G	0.78
GBM	chr8	144435781	Missense_Mutation	novel	M884I	0.43
GBM	chr8	144436960	Intron	rs200692030		0.32
GBM	chr8	144441014	Silent	novel	F321F	0.47
GBM	chr8	144442708	Missense_Mutation	rs748017086	D183N	0.41
GBM	chr8	144432400	Missense_Mutation	novel	A1207V	0.65
GBM	chr8	144433660	Missense_Mutation	rs781935858	R1163C	0.1
GBM	chr8	144436630	Missense_Mutation	NA	D648N	0.38
GBM	chr8	144435817	Silent	NA	P872P	0.3
HNSC	chr8	144436856	Silent	novel	E597E	0.46
HNSC	chr8	144435816	Missense_Mutation	rs757192033	R873C	0.35
HNSC	chr8	144435817	Silent	NA	P872P	0.35
HNSC	chr8	144433659	Missense_Mutation	rs782299928	R1163H	0.08
HNSC	chr8	144433624	Missense_Mutation	novel	L1175V	0.11
HNSC	chr8	144432373	Missense_Mutation	novel	G1216D	0.11
HNSC	chr8	144432374	Missense_Mutation	rs200752425	G1216S	0.11
HNSC	chr8	144430500	Silent	novel	L1283L	0.3
KICH	chr8	144436613	Silent	rs753823956	T653T	0.1
KICH	chr8	144442679	Splice_Region	rs755618655	A192A	0.18
KIRC	chr8	144440840	Missense_Mutation	rs763201864	G348R	0.16
KIRC	chr8	144441045	Missense_Mutation	NA	M311K	0.17
KIRP	chr8	144443205	Missense_Mutation	NA	R127S	0.33
LGG	chr8	144434254	Silent	rs142494135	A1037A	0.29
LGG	chr8	144440453	Silent	novel	I396I	0.42
LGG	chr8	144442382	Silent	rs569775648	R203R	0.4
LGG	chr8	144434148	Missense_Mutation	rs782040610	R1073W	0.17
LIHC	chr8	144435053	Missense_Mutation	NA	Q990H	0.22
LIHC	chr8	144442776	Missense_Mutation	novel	M160T	0.31
LIHC	chr8	144441001	Missense_Mutation	NA	D326H	0.45
LIHC	chr8	144443275	Missense_Mutation	NA	T104K	0.32
LIHC	chr8	144434206	Silent	NA	A1053A	0.1
LUAD	chr8	144436320	Missense_Mutation	NA	S705G	0.07
LUAD	chr8	144434183	Missense_Mutation	NA	P1061L	0.39
LUAD	chr8	144441072	Missense_Mutation	novel	A302D	0.28
LUAD	chr8	144435766	Silent	novel	A889A	0.22
LUAD	chr8	144442257	Missense_Mutation	novel	C245F	0.3
LUAD	chr8	144436343	Missense_Mutation	NA	P697R	0.17
LUSC	chr8	144438477	Silent	NA	V549V	0.22
LUSC	chr8	144440168	Frame_Shift_Del	novel	*R443Afs6**	0.13
LUSC	chr8	144442780	Missense_Mutation	novel	E159K	0.48
LUSC	chr8	144442286	Missense_Mutation	novel	M235I	0.09
LUSC	chr8	144435902	Missense_Mutation	rs200092098	R844H	0.28
LUSC	chr8	144432298	Missense_Mutation	NA	R1241L	0.26
LUSC	chr8	144433622	Silent	rs782105382	L1175L	0.23
LUSC	chr8	144436420	Splice_Site	novel	X672_splice	0.09
LUSC	chr8	144442376	Silent	NA	R205R	0.15
LUSC	chr8	144434147	Missense_Mutation	NA	R1073L	0.41
LUSC	chr8	144435870	Missense_Mutation	novel	D855H	0.08
LUSC	chr8	144440819	Missense_Mutation	NA	H355Y	0.34
LUSC	chr8	144435707	Missense_Mutation	novel	P909H	0.34
LUSC	chr8	144440150	Missense_Mutation	NA	E451Q	0.27
LUSC	chr8	144436296	Missense_Mutation	novel	Q713K	0.21
LUSC	chr8	144438670	Silent	NA	R516R	0.44
OV	chr8	144440045	Missense_Mutation	NA	G486C	0.27
OV	chr8	144442768	Missense_Mutation	NA	R163C	0.05
OV	chr8	144430488	Missense_Mutation	novel	P1287T	0.23
PAAD	chr8	144435016	Splice_Site	novel	X1002_splice	0.29
PRAD	chr8	144433654	Nonsense_Mutation	novel	Q1165*	0.15
PRAD	chr8	144436575	Missense_Mutation	rs747508334	A666V	0.36
PRAD	chr8	144442349	Silent	rs765218083	R214R	0.5
READ	chr8	144436894	Missense_Mutation	rs747672856	G585R	0.4
READ	chr8	144440391	Missense_Mutation	rs750087651	A417V	0.3
READ	chr8	144442265	Silent	rs112264814	S242S	0.19
SARC	chr8	144435020	Silent	rs558700548	D1001D	0.9
SARC	chr8	144433691	Silent	novel	L1152L	0.24
SARC	chr8	144435969	Missense_Mutation	novel	A822T	0.28
SARC	chr8	144443256	Missense_Mutation	novel	W110C	0.2
SARC	chr8	144433716	Missense_Mutation	novel	G1144D	0.25
SARC	chr8	144441007	Missense_Mutation	novel	A324T	0.28
SARC	chr8	144441008	Silent	rs141212804	K323K	0.28
SKCM	chr8	144436906	Silent	novel	L581L	0.26
SKCM	chr8	144440424	Missense_Mutation	novel	A406V	0.75
SKCM	chr8	144436290	Missense_Mutation	novel	H715Y	0.3
SKCM	chr8	144436352	Missense_Mutation	NA	P694L	0.09
SKCM	chr8	144436897	Missense_Mutation	novel	H584Y	0.09
SKCM	chr8	144441038	Silent	novel	I313I	0.27
SKCM	chr8	144432437	Missense_Mutation	NA	S1195P	0.59
SKCM	chr8	144436814	Silent	rs371923350	F611F	0.46
SKCM	chr8	144442075	Missense_Mutation	novel	P276L	0.24
SKCM	chr8	144436967	Intron	novel		0.31
SKCM	chr8	144435728	Missense_Mutation	rs758153285	P902L	0.23
SKCM	chr8	144436591	Missense_Mutation	novel	E661K	0.21
SKCM	chr8	144436592	Missense_Mutation	novel	M660I	0.23
SKCM	chr8	144442289	Silent	NA	T234T	0.36
SKCM	chr8	144434078	Missense_Mutation	NA	T1096I	0.22
SKCM	chr8	144442268	Silent	NA	E241E	0.25
SKCM	chr8	144434050	Silent	NA	L1105L	0.38
SKCM	chr8	144434030	Missense_Mutation	NA	P1112H	0.21
SKCM	chr8	144431103	Missense_Mutation	novel	D1262Y	0.64
SKCM	chr8	144432342	Silent	novel	V1226V	0.26
SKCM	chr8	144433720	Missense_Mutation	NA	D1143Y	0.29
SKCM	chr8	144436778	Silent	rs756598288	S623S	0.41
STAD	chr8	144436776	Missense_Mutation	rs767859903	V624A	0.12
STAD	chr8	144435666	Nonsense_Mutation	NA	Q923*	0.11
STAD	chr8	144436289	Missense_Mutation	novel	H715R	0.13
STAD	chr8	144432423	Silent	rs374357745	N1199N	0.1
STAD	chr8	144441096	Missense_Mutation	rs764909171	R294Q	0.18
STAD	chr8	144440842	Missense_Mutation	rs752005007	P347L	0.09
STAD	chr8	144435811	Silent	novel	A874A	0.26
STAD	chr8	144437037	Silent	rs750120871	Y572Y	0.14
STAD	chr8	144436105	Silent	rs545590970	P776P	0.33
STAD	chr8	144436894	Missense_Mutation	rs747672856	G585R	0.17
STAD	chr8	144434841	Missense_Mutation	rs747175296	Y1019H	0.2
STAD	chr8	144435763	Silent	NA	P890P	0.06
STAD	chr8	144438720	Missense_Mutation	NA	G499D	0.17
STAD	chr8	144440384	Silent	NA	S419S	0.08
STAD	chr8	144440867	Missense_Mutation	NA	R339C	0.3
STAD	chr8	144433638	Missense_Mutation	novel	G1170D	0.13
STAD	chr8	144441001	Missense_Mutation	NA	D326H	0.2
STAD	chr8	144442296	Missense_Mutation	rs368498512	A232V	0.16
STAD	chr8	144430439	Missense_Mutation	NA	K1303R	0.29
STAD	chr8	144440060	Missense_Mutation	rs146174683	E481K	0.09
STAD	chr8	144432373	Missense_Mutation	NA	G1216V	0.25
STAD	chr8	144435070	Frame_Shift_Del	novel	*A985Pfs23**	0.21
STAD	chr8	144442254	Missense_Mutation	novel	V246E	0.65
STAD	chr8	144440732	Missense_Mutation	rs201893250	G384S	0.26
STAD	chr8	144438523	Missense_Mutation	novel	H534R	0.13
STAD	chr8	144436997	Intron	novel		0.28
STAD	chr8	144440406	Frame_Shift_Del	novel	*P412Rfs31**	0.21
STAD	chr8	144430411	Silent	NA	G1312G	0.25
THCA	chr8	144438696	Missense_Mutation	novel	D507V	0.25
THYM	chr8	144438553	Missense_Mutation	novel	R524Q	0.13
UCEC	chr8	144433659	Missense_Mutation	rs782299928	R1163H	0.36
UCEC	chr8	144440045	Missense_Mutation	rs565607454	G486S	0.23
UCEC	chr8	144435667	Silent	NA	G922G	0.5
UCEC	chr8	144442704	Missense_Mutation	novel	Y184C	0.45
UCEC	chr8	144438673	Missense_Mutation	novel	G515S	0.42
UCEC	chr8	144435342	Intron	NA		0.33
UCEC	chr8	144436885	Missense_Mutation	NA	V588L	0.32
UCEC	chr8	144443167	Missense_Mutation	NA	S140N	0.21
UCEC	chr8	144435809	Missense_Mutation	rs147256304	R875Q	0.35
UCEC	chr8	144440831	Missense_Mutation	rs753001104	R351W	0.46
UCEC	chr8	144440202	Silent	novel	V433V	0.21
UCEC	chr8	144443285	Missense_Mutation	rs200649272	R101C	0.11
UCEC	chr8	144436937	Intron	rs761834147		0.33
UCEC	chr8	144438491	Missense_Mutation	rs202000622	V545I	0.13
UCEC	chr8	144436843	Frame_Shift_Del	NA	*L602Sfs41**	0.24
UCEC	chr8	144436614	Missense_Mutation	rs755055463	T653M	0.39
UCEC	chr8	144438491	Missense_Mutation	rs202000622	V545I	0.28
UCEC	chr8	144441011	Silent	rs756218352	S322S	0.06
UCEC	chr8	144436635	Missense_Mutation	rs771375609	R646H	0.27
UCEC	chr8	144433592	Silent	novel	F1185F	0.58
UCEC	chr8	144440100	Missense_Mutation	novel	E467D	0.34
UCEC	chr8	144436273	Silent	NA	P720P	0.25
UCEC	chr8	144442238	Splice_Region	novel		0.29
UCEC	chr8	144431120	Missense_Mutation	novel	S1256Y	0.11
UCEC	chr8	144436782	Missense_Mutation	novel	A622V	0.45
UCEC	chr8	144438532	Missense_Mutation	novel	T531I	0.33
UCEC	chr8	144443284	Missense_Mutation	novel	R101H	0.32
UCEC	chr8	144434019	Missense_Mutation	rs782353998	R1116C	0.33
UCEC	chr8	144436768	Missense_Mutation	rs751754276	R627C	0.4
UCEC	chr8	144434019	Missense_Mutation	rs782353998	R1116C	0.28
UCEC	chr8	144440022	Splice_Region	novel	G493G	0.42
UCEC	chr8	144436814	Silent	rs371923350	F611F	0.5
UCEC	chr8	144436859	Silent	rs750764114	C596C	0.36
UCEC	chr8	144435392	Intron	novel		0.13
UCEC	chr8	144435679	Silent	novel	S918S	0.47
UCEC	chr8	144442064	Missense_Mutation	rs566845306	A280T	0.59
UCEC	chr8	144436028	Missense_Mutation	novel	A802V	0.53
UCEC	chr8	144438741	Splice_Region	novel		0.4
UCEC	chr8	144430533	Missense_Mutation	novel	L1272I	0.1
UCEC	chr8	144435845	Missense_Mutation	novel	S863Y	0.31
UCEC	chr8	144440057	Missense_Mutation	novel	A482T	0.35
UCEC	chr8	144440737	Missense_Mutation	rs370126528	R382H	0.27
UCEC	chr8	144436978	Intron	novel		0.45
UCS	chr8	144436043	Missense_Mutation	rs376067225	R797Q	0.8

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1174	0.15559
LGG	DEL	0.0487	0.014004
SARC	AMP	0.249	0.18425
SKCM	AMP	0.4469	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.024	Kaplan-Meier Survival Analysis
SARC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.00017	Kaplan-Meier Survival Analysis
SKCM	0.003	Kaplan-Meier Survival Analysis
LUSC	0.012	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
PCPG	0.046	Kaplan-Meier Survival Analysis
LAML	0.003	Kaplan-Meier Survival Analysis
KICH	0.02	Kaplan-Meier Survival Analysis
UCEC	0.0087	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.042	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.035	Kaplan-Meier Survival Analysis
LUAD	0.0055	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000160949 (Gene tree)
Gene ID: 4796
Gene Symbol: TONSL
Alias: IKBR|NFKBIL2
Full Name: tonsoku like, DNA repair protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 15,714 bases
Position: chr8:144,428,775-144,444,488
Accession: 7801
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497613	TONSL-202	6607	-	-	- (aa)	-	-
ENST00000409379	TONSL-201	4502	XM_011517048	ENSP00000386239	1378 (aa)	XP_011515350	Q96HA7
ENST00000613741	TONSL-203	1713	-	ENSP00000484162	477 (aa)	-	A0A087X1F6

Gene Model

Click here to download ENSG00000160949's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160949's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	21055983.21055984.21055985.	IMP	Process
GO:0003714	transcription corepressor activity	7738005.	TAS	Function
GO:0005515	protein binding	21055983.21055984.21055985.21113133.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005662	DNA replication factor A complex	21055983.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0031297	replication fork processing	21055983.21055984.21055985.	IMP	Process
GO:0035101	FACT complex	21055983.	IDA	Component
GO:0042393	histone binding	21055983.21055984.	IDA	Function
GO:0042555	MCM complex	21055983.21055984.	IDA	Component
GO:0042994	cytoplasmic sequestering of transcription factor	7738005.	TAS	Process
GO:0043596	nuclear replication fork	21055983.21055984.	IDA	Component
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.