EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23894508	RecQL4 helicase amplification is involved in human breast tumorigenesis.	PLoS One	2013 Jul 22	Fang H	doi: 10.1371/journal.pone.0069600
22940096	RECQL4 in genomic instability and aging.	Trends Genet	2012 Dec	Croteau DL	doi: 10.1016/j.tig.2012.08.003
24746816	Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.	Cell Rep	2014 May 8	Wang JT	doi: 10.1016/j.celrep.2014.03.037
27287744	Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.	Ageing Res Rev	2017 Jan	Lu L	doi: 10.1016/j.arr.2016.06.002
27013200	Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway.	Cancer Res	2016 May 15	Mo D	doi: 10.1158/0008-5472.CAN-15-2361

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr8	144511526	Missense_Mutation	rs776146178	G1178R	0.22
BLCA	chr8	144514254	Missense_Mutation	novel	D605N	0.19
BLCA	chr8	144512244	Missense_Mutation	rs771349728	E1046K	0.25
BLCA	chr8	144516027	Silent	novel	V364V	0.13
BLCA	chr8	144512921	Missense_Mutation	novel	R894T	0.31
BLCA	chr8	144514008	Missense_Mutation	NA	E660K	0.55
BLCA	chr8	144512233	Silent	rs767781957	D1049D	0.22
BLCA	chr8	144514330	Silent	novel	L579L	0.43
BLCA	chr8	144512921	Missense_Mutation	novel	R894T	0.5
BLCA	chr8	144511370	3'UTR	novel		0.48
BLCA	chr8	144512477	Silent	novel	V990V	0.25
BLCA	chr8	144512426	Silent	novel	L1007L	0.21
BLCA	chr8	144512989	Silent	NA	E871E	0.36
BLCA	chr8	144515761	Splice_Region	novel		0.41
BRCA	chr8	144515239	Missense_Mutation	novel	T465R	0.32
BRCA	chr8	144512040	Silent	novel	C1088C	0.09
BRCA	chr8	144516761	Missense_Mutation	NA	G120R	0.12	DEAD
BRCA	chr8	144516641	Missense_Mutation	NA	P160S	0.24	DEAD
BRCA	chr8	144512686	Silent	NA	L947L	0.3
BRCA	chr8	144514099	Silent	NA	R629R	0.24
BRCA	chr8	144511973	Missense_Mutation	novel	E1111Q	0.09
BRCA	chr8	144514336	Silent	NA	L577L	0.15
CESC	chr8	144515213	Missense_Mutation	novel	E474Q	0.11
CESC	chr8	144512678	Missense_Mutation	novel	P950L	0.47
CESC	chr8	144513136	Splice_Region	rs767528470	G822G	0.52
CESC	chr8	144513406	Missense_Mutation	novel	A759S	0.31
CESC	chr8	144514482	Missense_Mutation	rs755425093	S555L	0.71
CESC	chr8	144515442	Frame_Shift_Del	novel	*T425Kfs133**	0.56
CESC	chr8	144511961	Missense_Mutation	NA	E1115Q	0.28
CESC	chr8	144513012	Missense_Mutation	novel	Q864E	0.09
CHOL	chr8	144514514	Silent	novel	L544L	0.48
COAD	chr8	144513610	Nonsense_Mutation	rs746691436	R721*	0.2
COAD	chr8	144516324	Silent	rs564678543	N265N	0.33
COAD	chr8	144512898	Missense_Mutation	rs761231404	R902W	0.27
COAD	chr8	144511412	3'UTR	novel		0.22
COAD	chr8	144515995	Missense_Mutation	rs398124115	R375H	0.37
COAD	chr8	144514508	Silent	rs775478350	P546P	0.43
COAD	chr8	144511305	3'UTR	novel		0.14
COAD	chr8	144516508	Missense_Mutation	NA	A204G	0.26	DEAD
COAD	chr8	144512965	Frame_Shift_Ins	NA	*Q880Sfs4**	0.25
COAD	chr8	144513684	Missense_Mutation	NA	R696H	0.33
COAD	chr8	144516123	Missense_Mutation	NA	K332N	0.19
COAD	chr8	144516458	Missense_Mutation	NA	I221V	0.32	DEAD
COAD	chr8	144512067	Splice_Region	rs770553956	S1079S	0.12
COAD	chr8	144513594	Missense_Mutation	novel	A726V	0.17
COAD	chr8	144515009	Missense_Mutation	rs762113412	A516V	0.14
COAD	chr8	144517167	Frame_Shift_Del	novel	*H81Ifs2**	0.12
COAD	chr8	144516025	Missense_Mutation	rs549497811	R365Q	0.24
COAD	chr8	144515014	Silent	rs368572714	L514L	0.28
ESCA	chr8	144513642	Missense_Mutation	rs781121286	R710H	0.25
ESCA	chr8	144513702	Missense_Mutation	rs369950284	T690M	0.21
ESCA	chr8	144514302	Missense_Mutation	novel	G589S	0.16
GBM	chr8	144512049	Silent	rs779365826	C1085C	0.6
GBM	chr8	144516403	Missense_Mutation	novel	A239D	0.12	DEAD
GBM	chr8	144516275	Missense_Mutation	novel	A282S	0.13
GBM	chr8	144516000	Silent	novel	L373L	0.97
GBM	chr8	144511988	Missense_Mutation	rs770193726	R1106C	0.31
HNSC	chr8	144513257	Silent	rs377301609	D808D	0.41
HNSC	chr8	144516682	Missense_Mutation	novel	G146V	0.35	DEAD
HNSC	chr8	144517185	Silent	novel	P73P	0.4
HNSC	chr8	144515452	Missense_Mutation	rs757872564	E422K	0.07
HNSC	chr8	144511420	3'UTR	rs200068546		0.13
HNSC	chr8	144516765	Splice_Site	novel	X119_splice	0.31
HNSC	chr8	144512024	Missense_Mutation	novel	E1094K	0.13
HNSC	chr8	144512170	Silent	rs539631209	L1070L	0.12
HNSC	chr8	144512244	Missense_Mutation	novel	E1046Q	0.17
HNSC	chr8	144514481	Silent	rs756736123	S555S	0.25
KIRP	chr8	144516151	Missense_Mutation	novel	S323N	0.65
LGG	chr8	144515196	Frame_Shift_Del	novel	*A480Pfs78**	0.67
LGG	chr8	144514463	Silent	novel	Q561Q	0.17
LGG	chr8	144515350	Missense_Mutation	novel	L456M	0.13
LGG	chr8	144515762	Splice_Site	novel	X420_splice	0.44
LGG	chr8	144513270	Missense_Mutation	novel	R804Q	0.4
LIHC	chr8	144515334	Missense_Mutation	NA	Q461L	0.07
LIHC	chr8	144512948	Missense_Mutation	NA	L885P	0.22
LIHC	chr8	144513329	Silent	novel	R784R	0.35
LIHC	chr8	144516371	Missense_Mutation	NA	G250R	0.34	DEAD
LIHC	chr8	144511736	Silent	novel	L1149L	0.06
LIHC	chr8	144514100	Missense_Mutation	rs761794554	R629Q	0.09
LIHC	chr8	144511928	Missense_Mutation	rs779826649	E1126K	0.13
LIHC	chr8	144513395	Silent	novel	Q762Q	0.11
LIHC	chr8	144515042	Missense_Mutation	novel	G505A	0.07
LIHC	chr8	144514461	Missense_Mutation	rs375562152	R562Q	0.38
LUAD	chr8	144512506	Missense_Mutation	NA	G981R	0.21
LUAD	chr8	144512286	Missense_Mutation	novel	E1032Q	0.1
LUAD	chr8	144516652	Missense_Mutation	NA	S156N	0.09	DEAD
LUAD	chr8	144517440	Missense_Mutation	NA	E63Q	0.24
LUAD	chr8	144516766	Splice_Site	NA	X119_splice	0.19
LUAD	chr8	144516553	Missense_Mutation	NA	G189V	0.32	DEAD
LUSC	chr8	144515784	Missense_Mutation	novel	A413E	0.29
LUSC	chr8	144511962	Silent	NA	Q1114Q	0.26
LUSC	chr8	144514964	Missense_Mutation	novel	S531F	0.14
LUSC	chr8	144515074	Splice_Site	novel	X495_splice	0.09
LUSC	chr8	144517124	Missense_Mutation	NA	P94S	0.47
LUSC	chr8	144516000	Frame_Shift_Ins	novel	*L374Qfs51**	0.22
LUSC	chr8	144514018	Silent	novel	L656L	1
LUSC	chr8	144512895	Missense_Mutation	novel	A903T	0.5
LUSC	chr8	144513444	Missense_Mutation	rs201883228	A746V	0.59
LUSC	chr8	144516755	Missense_Mutation	rs750245958	A122T	0.19	DEAD
PAAD	chr8	144511334	3'UTR	novel		0.16
PAAD	chr8	144514996	Silent	novel	S520S	0.23
PAAD	chr8	144516060	Silent	rs750709443	Y353Y	0.19
PRAD	chr8	144517167	Frame_Shift_Del	novel	*H81Ifs2**	0.22
PRAD	chr8	144516334	Missense_Mutation	rs781569277	R262Q	0.08	DEAD
PRAD	chr8	144516609	Silent	novel	G170G	0.14
PRAD	chr8	144512498	Silent	rs751727270	S983S	0.31
READ	chr8	144511436	Missense_Mutation	rs41555416	R1208C	0.41
SARC	chr8	144512246	Missense_Mutation	novel	A1045D	0.08
SARC	chr8	144511368	3'UTR	novel		0.57
SARC	chr8	144516080	Missense_Mutation	rs534507419	R347C	0.26
SKCM	chr8	144511305	3'UTR	novel		0.19
SKCM	chr8	144514961	Missense_Mutation	NA	P532L	0.39
SKCM	chr8	144514461	Missense_Mutation	rs375562152	R562Q	0.17
SKCM	chr8	144515413	Missense_Mutation	rs769553486	P435S	0.34
SKCM	chr8	144516706	Missense_Mutation	novel	S138F	0.6	DEAD
SKCM	chr8	144516011	Missense_Mutation	rs368979398	R370C	0.36
SKCM	chr8	144516223	Missense_Mutation	NA	P299L	0.52
SKCM	chr8	144516227	Missense_Mutation	NA	P298S	0.35
SKCM	chr8	144516525	Silent	novel	V198V	0.25
SKCM	chr8	144513278	Silent	rs778794472	A801A	0.42
SKCM	chr8	144513279	Missense_Mutation	novel	A801V	0.46
STAD	chr8	144512874	Missense_Mutation	rs374225917	V910I	0.17
STAD	chr8	144511540	Missense_Mutation	novel	P1173L	0.24
STAD	chr8	144512236	Missense_Mutation	novel	K1048N	0.32
STAD	chr8	144514977	Missense_Mutation	rs760080894	T527A	0.22
STAD	chr8	144513002	Missense_Mutation	NA	A867V	0.3
STAD	chr8	144512672	Frame_Shift_Del	novel	*G952Afs92**	0.22
STAD	chr8	144515847	Frame_Shift_Del	rs754177646	*G392Vfs14**	0.29
STAD	chr8	144512315	Missense_Mutation	rs560476442	R1022H	0.25
STAD	chr8	144512484	Missense_Mutation	rs760325940	D988G	0.38
STAD	chr8	144512518	Missense_Mutation	rs780492921	D977N	0.25
STAD	chr8	144512490	Missense_Mutation	NA	E986G	0.26
STAD	chr8	144515803	Missense_Mutation	rs117670586	E407K	0.44
STAD	chr8	144512319	Missense_Mutation	rs137853232	R1021W	0.27
STAD	chr8	144516129	In_Frame_Del	novel	R329_A330del	0.24
STAD	chr8	144516681	Silent	rs764797288	G146G	0.46
STAD	chr8	144512234	Missense_Mutation	NA	D1049G	0.32
STAD	chr8	144515038	Silent	rs757280460	A506A	0.17
STAD	chr8	144513343	Missense_Mutation	rs372741479	R780W	0.16
STAD	chr8	144515871	Missense_Mutation	rs376045624	R384Q	0.2
STAD	chr8	144513670	Missense_Mutation	NA	D701N	0.54
TGCT	chr8	144515766	Missense_Mutation	novel	P419L	0.33
THCA	chr8	144514186	Splice_Region	novel		0.34
UCEC	chr8	144516174	Silent	rs371593078	S315S	0.1
UCEC	chr8	144512259	Missense_Mutation	novel	G1041W	0.34
UCEC	chr8	144512045	Missense_Mutation	rs768802673	P1087S	0.42
UCEC	chr8	144512248	Silent	rs373238823	T1044T	0.4
UCEC	chr8	144515235	Silent	NA	P466P	0.4
UCEC	chr8	144513458	Silent	rs34271972	A741A	0.53
UCEC	chr8	144513646	Missense_Mutation	rs199562131	R709W	0.37
UCEC	chr8	144511370	3'UTR	novel		0.16
UCEC	chr8	144513444	Missense_Mutation	rs201883228	A746V	0.49
UCEC	chr8	144516715	Missense_Mutation	rs748201614	S135Y	0.38	DEAD
UCEC	chr8	144515185	Missense_Mutation	NA	P483H	0.15
UCEC	chr8	144517071	Silent	NA	A111A	0.33
UCEC	chr8	144515202	Silent	NA	G477G	0.47
UCEC	chr8	144514198	Silent	rs368736533	R623R	0.31
UCEC	chr8	144516324	Silent	rs564678543	N265N	0.2
UCEC	chr8	144512881	Silent	NA	Q907Q	0.32
UCEC	chr8	144512158	Silent	novel	F1074F	0.2
UCEC	chr8	144512450	Missense_Mutation	novel	E999D	0.27
UCEC	chr8	144511997	Missense_Mutation	NA	L1103M	0.28
UCEC	chr8	144515009	Missense_Mutation	rs762113412	A516V	0.27
UCEC	chr8	144512190	Missense_Mutation	rs781751586	R1064C	0.56
UCEC	chr8	144516495	Silent	novel	C208C	0.22
UCEC	chr8	144513424	Missense_Mutation	rs367570292	R753W	0.39
UCEC	chr8	144512966	Frame_Shift_Del	novel	*P879Lfs69**	0.27
UCEC	chr8	144516377	Missense_Mutation	rs540719285	R248C	0.55	DEAD
UCEC	chr8	144513641	Silent	rs757037180	R710R	0.61
UCEC	chr8	144511707	Missense_Mutation	NA	A1159V	0.46
UCEC	chr8	144511983	Nonsense_Mutation	rs376392965	Y1107*	0.08
UCEC	chr8	144511483	Missense_Mutation	novel	F1192C	0.15
UCEC	chr8	144511765	Missense_Mutation	rs375432640	R1140C	0.33
UCEC	chr8	144512174	Missense_Mutation	rs752847936	R1069H	0.47
UCEC	chr8	144516214	Missense_Mutation	novel	P302H	0.43
UCEC	chr8	144513646	Silent	novel	R709R	0.2
UCEC	chr8	144511941	Silent	rs148752485	D1121D	0.07
UCEC	chr8	144516601	Missense_Mutation	NA	Q173R	0.32	DEAD
UCEC	chr8	144516302	Missense_Mutation	rs34103564	A273T	0.55
UCEC	chr8	144516262	Missense_Mutation	rs757320755	S286L	0.36
UCEC	chr8	144516265	Frame_Shift_Del	novel	*P285Hfs8**	0.24
UCEC	chr8	144513482	Splice_Site	novel	X734_splice	0.37
UCEC	chr8	144516055	Missense_Mutation	rs374743591	R355Q	0.31
UCEC	chr8	144515770	Missense_Mutation	novel	R418G	0.47
UCEC	chr8	144511941	Silent	rs148752485	D1121D	0.37
UCEC	chr8	144515795	Silent	novel	F409F	0.45
UCEC	chr8	144511329	3'UTR	novel		0.44
UCEC	chr8	144512247	Missense_Mutation	rs35348691	A1045T	0.32
UCEC	chr8	144513065	Missense_Mutation	novel	V846A	0.25
UCEC	chr8	144516579	Missense_Mutation	novel	S180R	0.42	DEAD
UCEC	chr8	144517172	Missense_Mutation	rs768539707	W78G	0.31
UCEC	chr8	144511494	Silent	novel	L1188L	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1174	0.15559
LGG	DEL	0.0487	0.014004
SARC	AMP	0.249	0.18425
SKCM	AMP	0.4469	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
THYM	0.023	Kaplan-Meier Survival Analysis
STAD	0.0096	Kaplan-Meier Survival Analysis
SARC	0.0021	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
UCS	0.019	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PRAD	0.04	Kaplan-Meier Survival Analysis
KIRP	0.0017	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.0042	Kaplan-Meier Survival Analysis
LGG	0.00016	Kaplan-Meier Survival Analysis
CHOL	0.023	Kaplan-Meier Survival Analysis
LUAD	0.0071	Kaplan-Meier Survival Analysis
UVM	0.00041	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000160957 (Gene tree)
Gene ID: 9401
Gene Symbol: RECQL4
Alias: RecQ4
Full Name: RecQ like helicase 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 6,562 bases
Position: chr8:144,511,284-144,517,845
Accession: 9949
RBP type: canonical RBP
Summary: The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000483145	DEAD	PF00270.29	7.6e-16	1	1
ENSP00000482313	DEAD	PF00270.29	1.3e-15	1	1
ENSP00000476551	DEAD	PF00270.29	1.1e-12	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26888063	Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases.	Sci Rep	2016 Feb 18	Marino F	doi: 10.1038/srep21501.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000524998	RECQL4-202	686	-	ENSP00000476579	229 (aa)	-	V9GYB6
ENST00000301323	RECQL4-201	781	-	ENSP00000476426	37 (aa)	-	V9GY60
ENST00000531875	RECQL4-204	988	-	ENSP00000477910	293 (aa)	-	A0A087WTJ0
ENST00000534626	RECQL4-208	1165	-	ENSP00000477457	389 (aa)	-	V9GZ64
ENST00000617875	RECQL4-209	3809	XM_011517384	ENSP00000482313	1208 (aa)	XP_011515686	O94761
ENST00000534270	RECQL4-206	517	-	-	- (aa)	-	-
ENST00000532846	RECQL4-205	1055	-	ENSP00000476551	352 (aa)	-	V9GYA3
ENST00000621189	RECQL4-210	3896	XM_017014000	ENSP00000483145	851 (aa)	XP_016869489	A0A087X072
ENST00000534538	RECQL4-207	725	-	ENSP00000476318	15 (aa)	-	V9GY28
ENST00000529424	RECQL4-203	324	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000160957's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000160957	Education	9E-6	25201988

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000160957	rs4244612	8	144516318	C	General cognitive ability	29844566	z-score increase	5.569	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000160957's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000160957	RECQL4	99	60.889	ENSAPOG00000016945	recql4	99	39.376	Acanthochromis_polyacanthus
ENSG00000160957	RECQL4	99	78.873	ENSAMEG00000005460	RECQL4	99	67.810	Ailuropoda_melanoleuca
ENSG00000160957	RECQL4	94	64.706	ENSAOCG00000004254	recql4	74	48.485	Amphiprion_ocellaris
ENSG00000160957	RECQL4	99	57.438	ENSAPEG00000005709	recql4	99	40.409	Amphiprion_percula
ENSG00000160957	RECQL4	99	62.896	ENSATEG00000011464	recql4	95	56.836	Anabas_testudineus
ENSG00000160957	RECQL4	99	65.000	ENSACAG00000010589	RECQL4	100	48.506	Anolis_carolinensis
ENSG00000160957	RECQL4	100	88.290	ENSANAG00000024497	RECQL4	100	85.903	Aotus_nancymaae
ENSG00000160957	RECQL4	90	67.647	ENSACLG00000011982	recql4	66	51.391	Astatotilapia_calliptera
ENSG00000160957	RECQL4	84	61.661	ENSAMXG00000004768	recql4	72	49.407	Astyanax_mexicanus
ENSG00000160957	RECQL4	99	91.469	ENSCJAG00000021401	RECQL4	99	85.161	Callithrix_jacchus
ENSG00000160957	RECQL4	99	71.724	ENSCAFG00000001569	RECQL4	98	67.848	Canis_familiaris
ENSG00000160957	RECQL4	99	72.664	ENSCHIG00000011146	RECQL4	99	64.545	Capra_hircus
ENSG00000160957	RECQL4	99	81.661	ENSTSYG00000012090	RECQL4	99	80.657	Carlito_syrichta
ENSG00000160957	RECQL4	99	73.630	ENSCAPG00000017735	RECQL4	99	66.449	Cavia_aperea
ENSG00000160957	RECQL4	99	75.342	ENSCPOG00000015563	RECQL4	99	66.130	Cavia_porcellus
ENSG00000160957	RECQL4	99	91.469	ENSCCAG00000035749	RECQL4	100	85.903	Cebus_capucinus
ENSG00000160957	RECQL4	99	92.891	ENSCATG00000030745	RECQL4	99	90.000	Cercocebus_atys
ENSG00000160957	RECQL4	99	75.926	ENSCLAG00000013847	RECQL4	99	66.907	Chinchilla_lanigera
ENSG00000160957	RECQL4	99	92.891	ENSCSAG00000008275	RECQL4	99	89.109	Chlorocebus_sabaeus
ENSG00000160957	RECQL4	99	55.455	ENSCPBG00000019003	RECQL4	99	53.271	Chrysemys_picta_bellii
ENSG00000160957	RECQL4	100	91.864	ENSCANG00000043305	RECQL4	100	89.369	Colobus_angolensis_palliatus
ENSG00000160957	RECQL4	100	73.720	ENSCGRG00001015863	Recql4	99	64.583	Cricetulus_griseus_chok1gshd
ENSG00000160957	RECQL4	100	73.720	ENSCGRG00000013535	Recql4	99	66.113	Cricetulus_griseus_crigri
ENSG00000160957	RECQL4	99	62.500	ENSCSEG00000014814	recql4	90	57.407	Cynoglossus_semilaevis
ENSG00000160957	RECQL4	98	52.672	ENSCVAG00000007993	recql4	85	47.162	Cyprinodon_variegatus
ENSG00000160957	RECQL4	99	58.678	ENSDARG00000077516	recql4	91	47.147	Danio_rerio
ENSG00000160957	RECQL4	90	76.518	ENSDNOG00000002674	RECQL4	98	75.709	Dasypus_novemcinctus
ENSG00000160957	RECQL4	99	68.166	ENSDORG00000002297	Recql4	99	61.013	Dipodomys_ordii
ENSG00000160957	RECQL4	99	71.379	ENSETEG00000011107	RECQL4	85	69.014	Echinops_telfairi
ENSG00000160957	RECQL4	99	45.675	ENSEBUG00000006367	-	77	67.857	Eptatretus_burgeri
ENSG00000160957	RECQL4	99	80.282	ENSECAG00000018665	RECQL4	99	77.647	Equus_caballus
ENSG00000160957	RECQL4	99	76.303	ENSEEUG00000005223	RECQL4	78	72.186	Erinaceus_europaeus
ENSG00000160957	RECQL4	99	56.846	ENSELUG00000022177	recql4	75	46.213	Esox_lucius
ENSG00000160957	RECQL4	99	75.463	ENSFDAG00000014917	RECQL4	100	65.326	Fukomys_damarensis
ENSG00000160957	RECQL4	99	55.000	ENSFHEG00000009855	recql4	75	48.259	Fundulus_heteroclitus
ENSG00000160957	RECQL4	99	55.556	ENSGMOG00000001340	recql4	99	42.443	Gadus_morhua
ENSG00000160957	RECQL4	99	57.919	ENSGALG00000042375	-	67	51.095	Gallus_gallus
ENSG00000160957	RECQL4	99	57.025	ENSGAFG00000009575	recql4	75	49.096	Gambusia_affinis
ENSG00000160957	RECQL4	99	56.612	ENSGACG00000015014	recql4	74	48.847	Gasterosteus_aculeatus
ENSG00000160957	RECQL4	99	55.833	ENSGAGG00000021941	RECQL4	80	52.916	Gopherus_agassizii
ENSG00000160957	RECQL4	100	97.773	ENSGGOG00000014319	RECQL4	100	97.773	Gorilla_gorilla
ENSG00000160957	RECQL4	90	67.647	ENSHBUG00000019085	recql4	66	51.592	Haplochromis_burtoni
ENSG00000160957	RECQL4	99	76.389	ENSHGLG00000015925	RECQL4	98	66.581	Heterocephalus_glaber_female
ENSG00000160957	RECQL4	99	76.389	ENSHGLG00100007626	RECQL4	99	66.522	Heterocephalus_glaber_male
ENSG00000160957	RECQL4	99	56.735	ENSHCOG00000016157	recql4	99	49.262	Hippocampus_comes
ENSG00000160957	RECQL4	90	64.706	ENSIPUG00000004473	recql4	81	52.050	Ictalurus_punctatus
ENSG00000160957	RECQL4	99	76.887	ENSJJAG00000017588	Recql4	99	65.858	Jaculus_jaculus
ENSG00000160957	RECQL4	99	55.372	ENSKMAG00000009537	recql4	73	49.788	Kryptolebias_marmoratus
ENSG00000160957	RECQL4	99	61.538	ENSLBEG00000015884	recql4	97	54.658	Labrus_bergylta
ENSG00000160957	RECQL4	99	51.525	ENSLACG00000004466	recql4	83	48.621	Latimeria_chalumnae
ENSG00000160957	RECQL4	99	56.846	ENSLOCG00000007478	recql4	83	51.146	Lepisosteus_oculatus
ENSG00000160957	RECQL4	99	77.509	ENSLAFG00000009512	RECQL4	99	66.379	Loxodonta_africana
ENSG00000160957	RECQL4	99	93.365	ENSMFAG00000038185	RECQL4	99	89.835	Macaca_fascicularis
ENSG00000160957	RECQL4	99	93.365	ENSMMUG00000015588	RECQL4	99	88.366	Macaca_mulatta
ENSG00000160957	RECQL4	99	92.891	ENSMNEG00000036079	RECQL4	99	90.165	Macaca_nemestrina
ENSG00000160957	RECQL4	99	92.417	ENSMLEG00000036034	RECQL4	99	91.442	Mandrillus_leucophaeus
ENSG00000160957	RECQL4	97	64.706	ENSMAMG00000015565	recql4	67	51.148	Mastacembelus_armatus
ENSG00000160957	RECQL4	99	61.991	ENSMZEG00005026699	recql4	96	56.653	Maylandia_zebra
ENSG00000160957	RECQL4	99	73.148	ENSMAUG00000008628	Recql4	99	63.607	Mesocricetus_auratus
ENSG00000160957	RECQL4	100	78.337	ENSMICG00000015923	RECQL4	100	77.986	Microcebus_murinus
ENSG00000160957	RECQL4	100	74.744	ENSMOCG00000009648	Recql4	100	64.833	Microtus_ochrogaster
ENSG00000160957	RECQL4	99	62.443	ENSMMOG00000018356	recql4	99	51.971	Mola_mola
ENSG00000160957	RECQL4	99	67.130	ENSMODG00000011014	RECQL4	99	53.871	Monodelphis_domestica
ENSG00000160957	RECQL4	99	60.000	ENSMALG00000007361	recql4	93	56.917	Monopterus_albus
ENSG00000160957	RECQL4	99	73.611	MGP_CAROLIEiJ_G0019945	Recql4	99	64.677	Mus_caroli
ENSG00000160957	RECQL4	99	73.611	ENSMUSG00000033762	Recql4	99	64.274	Mus_musculus
ENSG00000160957	RECQL4	99	74.074	MGP_PahariEiJ_G0019955	Recql4	99	64.640	Mus_pahari
ENSG00000160957	RECQL4	99	73.611	MGP_SPRETEiJ_G0020848	Recql4	99	64.677	Mus_spretus
ENSG00000160957	RECQL4	99	74.648	ENSMPUG00000006086	RECQL4	99	65.647	Mustela_putorius_furo
ENSG00000160957	RECQL4	99	76.056	ENSMLUG00000011295	RECQL4	100	66.640	Myotis_lucifugus
ENSG00000160957	RECQL4	99	78.241	ENSNGAG00000004346	Recql4	100	66.990	Nannospalax_galili
ENSG00000160957	RECQL4	100	93.857	ENSNLEG00000010900	RECQL4	100	84.269	Nomascus_leucogenys
ENSG00000160957	RECQL4	99	65.138	ENSMEUG00000001818	-	100	61.297	Notamacropus_eugenii
ENSG00000160957	RECQL4	99	74.882	ENSOPRG00000002588	RECQL4	93	63.770	Ochotona_princeps
ENSG00000160957	RECQL4	99	76.207	ENSODEG00000012082	RECQL4	99	66.129	Octodon_degus
ENSG00000160957	RECQL4	92	67.647	ENSONIG00000019801	recql4	84	44.891	Oreochromis_niloticus
ENSG00000160957	RECQL4	99	66.509	ENSOANG00000003526	RECQL4	99	50.954	Ornithorhynchus_anatinus
ENSG00000160957	RECQL4	99	58.228	ENSORLG00000024764	recql4	79	48.583	Oryzias_latipes
ENSG00000160957	RECQL4	90	70.588	ENSOMEG00000023534	recql4	77	60.841	Oryzias_melastigma
ENSG00000160957	RECQL4	100	77.441	ENSOGAG00000013008	RECQL4	100	69.901	Otolemur_garnettii
ENSG00000160957	RECQL4	99	73.460	ENSOARG00000012917	RECQL4	96	62.808	Ovis_aries
ENSG00000160957	RECQL4	100	98.120	ENSPPAG00000038772	RECQL4	94	98.147	Pan_paniscus
ENSG00000160957	RECQL4	100	98.472	ENSPTRG00000048119	RECQL4	100	98.472	Pan_troglodytes
ENSG00000160957	RECQL4	99	92.891	ENSPANG00000024705	RECQL4	99	89.835	Papio_anubis
ENSG00000160957	RECQL4	99	60.166	ENSPKIG00000020206	recql4	83	48.874	Paramormyrops_kingsleyae
ENSG00000160957	RECQL4	63	47.143	ENSPSIG00000003148	-	63	52.145	Pelodiscus_sinensis
ENSG00000160957	RECQL4	99	56.967	ENSPMGG00000021408	recql4	71	49.473	Periophthalmus_magnuspinnatus
ENSG00000160957	RECQL4	100	73.720	ENSPEMG00000008586	Recql4	100	64.824	Peromyscus_maniculatus_bairdii
ENSG00000160957	RECQL4	99	57.025	ENSPFOG00000005814	recql4	88	44.024	Poecilia_formosa
ENSG00000160957	RECQL4	99	57.025	ENSPLAG00000011704	recql4	93	42.939	Poecilia_latipinna
ENSG00000160957	RECQL4	99	57.025	ENSPMEG00000011683	recql4	80	48.692	Poecilia_mexicana
ENSG00000160957	RECQL4	99	56.198	ENSPREG00000012196	recql4	99	41.002	Poecilia_reticulata
ENSG00000160957	RECQL4	100	95.222	ENSPPYG00000018984	RECQL4	100	93.714	Pongo_abelii
ENSG00000160957	RECQL4	99	73.733	ENSPCAG00000014090	-	66	73.267	Procavia_capensis
ENSG00000160957	RECQL4	100	81.017	ENSPCOG00000013744	RECQL4	100	79.157	Propithecus_coquereli
ENSG00000160957	RECQL4	99	76.526	ENSPVAG00000006784	RECQL4	100	68.092	Pteropus_vampyrus
ENSG00000160957	RECQL4	99	60.633	ENSPNYG00000008927	recql4	96	56.390	Pundamilia_nyererei
ENSG00000160957	RECQL4	99	59.583	ENSPNAG00000005987	recql4	89	48.450	Pygocentrus_nattereri
ENSG00000160957	RECQL4	99	75.926	ENSRNOG00000032446	Recql4	99	64.588	Rattus_norvegicus
ENSG00000160957	RECQL4	100	92.542	ENSRROG00000040848	RECQL4	100	92.037	Rhinopithecus_roxellana
ENSG00000160957	RECQL4	99	89.100	ENSSBOG00000021445	RECQL4	99	85.286	Saimiri_boliviensis_boliviensis
ENSG00000160957	RECQL4	100	64.527	ENSSHAG00000010333	-	100	52.832	Sarcophilus_harrisii
ENSG00000160957	RECQL4	99	56.432	ENSSFOG00015010493	recql4	65	50.600	Scleropages_formosus
ENSG00000160957	RECQL4	99	61.991	ENSSMAG00000005002	recql4	97	52.871	Scophthalmus_maximus
ENSG00000160957	RECQL4	98	53.611	ENSSDUG00000013245	recql4	99	52.808	Seriola_dumerili
ENSG00000160957	RECQL4	97	54.039	ENSSLDG00000016407	recql4	99	52.927	Seriola_lalandi_dorsalis
ENSG00000160957	RECQL4	99	69.521	ENSSARG00000013351	-	91	74.074	Sorex_araneus
ENSG00000160957	RECQL4	99	51.142	ENSSPUG00000018087	RECQL4	99	49.659	Sphenodon_punctatus
ENSG00000160957	RECQL4	97	53.463	ENSSPAG00000006827	recql4	99	53.699	Stegastes_partitus
ENSG00000160957	RECQL4	99	76.526	ENSSSCG00000025736	RECQL4	98	70.673	Sus_scrofa
ENSG00000160957	RECQL4	99	49.123	ENSTRUG00000012749	recql4	88	47.277	Takifugu_rubripes
ENSG00000160957	RECQL4	99	57.261	ENSTNIG00000017539	recql4	89	44.349	Tetraodon_nigroviridis
ENSG00000160957	RECQL4	99	79.147	ENSUMAG00000019403	RECQL4	99	63.835	Ursus_maritimus
ENSG00000160957	RECQL4	99	58.921	ENSXETG00000016582	recql4	72	50.199	Xenopus_tropicalis
ENSG00000160957	RECQL4	99	62.385	ENSXCOG00000019857	recql4	98	54.002	Xiphophorus_couchianus
ENSG00000160957	RECQL4	99	61.991	ENSXMAG00000015315	recql4	98	53.819	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000405	bubble DNA binding	21873635.	IBA	Function
GO:0000405	bubble DNA binding	19177149.	IDA	Function
GO:0000723	telomere maintenance	22039056.	IMP	Process
GO:0000724	double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0000733	DNA strand renaturation	19177149.	IDA	Process
GO:0000781	chromosome, telomeric region	21873635.	IBA	Component
GO:0000781	chromosome, telomeric region	22039056.	IMP	Component
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003697	single-stranded DNA binding	21873635.	IBA	Function
GO:0004386	helicase activity	22039056.	TAS	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	21044950.22039056.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	19177149.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005694	chromosome	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006260	DNA replication	21873635.	IBA	Process
GO:0006260	DNA replication	19177149.	IDA	Process
GO:0006260	DNA replication	22039056.	IMP	Process
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006284	base-excision repair	21873635.	IBA	Process
GO:0006310	DNA recombination	21873635.	IBA	Process
GO:0007275	multicellular organism development	10319867.	TAS	Process
GO:0008284	positive regulation of cell proliferation	21873635.	IBA	Process
GO:0009378	four-way junction helicase activity	21873635.	IBA	Function
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0032357	oxidized purine DNA binding	21873635.	IBA	Function
GO:0032357	oxidized purine DNA binding	22039056.	IDA	Function
GO:0032508	DNA duplex unwinding	21873635.	IBA	Process
GO:0032508	DNA duplex unwinding	19177149.	IDA	Process
GO:0032508	DNA duplex unwinding	22039056.	TAS	Process
GO:0036310	annealing helicase activity	21873635.	IBA	Function
GO:0036310	annealing helicase activity	19177149.	IDA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	19177149.	IMP	Function
GO:0045740	positive regulation of DNA replication	21873635.	IBA	Process
GO:0061820	telomeric D-loop disassembly	21873635.	IBA	Process
GO:0061820	telomeric D-loop disassembly	22039056.	IDA	Process
GO:0061820	telomeric D-loop disassembly	22039056.	IGI	Process
GO:0061821	telomeric D-loop binding	21873635.	IBA	Function
GO:0061821	telomeric D-loop binding	22039056.	IDA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.