EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27768885p62 in Cancer: Signaling Adaptor Beyond Autophagy.Cell2016 Oct 20Moscat Jdoi: 10.1016/j.cell.2016.09.030.
29699801Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer.Gynecol Oncol2018 JulWang Jdoi: 10.1016/j.ygyno.2018.04.557
24553345Calpain-dependent clearance of the autophagy protein p62/SQSTM1 is a contributor to ??PK oncolytic activity in melanoma.Gene Ther2014 AprColunga Adoi: 10.1038/gt.2014.6
25088198Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways.Oncogene2015 Jun 4Cai-McRae Xdoi: 10.1038/onc.2014.244
27211490p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.Cancer Cell2016 Jun 13Umemura Adoi: 10.1016/j.ccell.2016.04.006
28724634Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation.J Biol Chem2017 Sep 8Sample Adoi: 10.1074/jbc.M117.786160
28846113VPS34 stimulation of p62 phosphorylation for cancer progression.Oncogene2017 Dec 14Jiang Xdoi: 10.1038/onc.2017.295
29729523High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance.Redox Biol2018 JulRyoo IGdoi: 10.1016/j.redox.2018.04.015
29634950Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor.Cancer Cell2018 Apr 9Huang Jdoi: 10.1016/j.ccell.2018.03.001.
29738493Autophagic Regulation of p62 is Critical for Cancer Therapy.Int J Mol Sci2018 May 8Islam MAdoi: 10.3390/ijms19051405.
26754771Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.Nat Commun2016 Jan 12Puvirajesinghe TMdoi: 10.1038/ncomms10318.
26707573Autophagy-associated proteins BAG3 and p62 in testicular cancer.Oncol Rep2016 MarBartsch Gdoi: 10.3892/or.2015.4505
26617774Beclin 1 and p62 expression in non-small cell lung cancer: relation with malignant behaviors and clinical outcome.Int J Clin Exp Pathol2015 Sep 1Wang X-
25103771IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells.J Cell Biochem2014 DecChang MAdoi: 10.1002/jcb.24897.
22525272The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells.Oncogene2013 Feb 7Galavotti Sdoi: 10.1038/onc.2012.111
23911927K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.Mol Cell2013 Aug 8Linares JFdoi: 10.1016/j.molcel.2013.06.020
12700667p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.Oncogene2003 Apr 17Thompson HG-
24122957p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.Prostate2014 FebChang MAdoi: 10.1002/pros.22737
19197142p62 degradation by autophagy: another way for cancer cells to survive under hypoxia.Autophagy2009 AprJaakkola PM-
22296116Sequestosome 1/p62: across diseases.Biomarkers2012 MarGeetha Tdoi: 10.3109/1354750X.2011.653986
26722036Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer.Anticancer Res2016 JanMasuda GO-
25925890Cytoplasmic Accumulation of Sequestosome 1 (p62) Is a Predictor of Biochemical Recurrence, Rapid Tumor Cell Proliferation, and Genomic Instability in Prostate Cancer.Clin Cancer Res2015 Aug 1Burdelski Cdoi: 10.1158/1078-0432.CCR-14-0620
27250032Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer.Oncotarget2016 Jun 28Schlfli AMdoi: 10.18632/oncotarget.9647.
29307823Autophagy-mediated upregulation of cytoplasmic claudin 1 stimulates the degradation of SQSTM1/p62 under starvation.Biochem Biophys Res Commun2018 Jan 29Kim Jdoi: 10.1016/j.bbrc.2018.01.017
28544335p62/sequestosome 1 in human colorectal carcinoma as a potent prognostic predictor associated with cell proliferation.Cancer Med2017 JunNakayama Sdoi: 10.1002/cam4.1093
28455291Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells.Mol Cell Proteomics2017 JulNguyen EVdoi: 10.1074/mcp.M116.058321
28617433Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop.Cell Death Dis2017 Jun 15Wang Ydoi: 10.1038/cddis.2017.265.
30067838Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation.PLoS One2018 Aug 1Battista RAdoi: 10.1371/journal.pone.0201621
29383752Metastatic prostate cancer-associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6.Prostate2018 MayJiang Xdoi: 10.1002/pros.23487
28855742Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer.Sci Rep2017 Aug 30Galindo-Moreno Mdoi: 10.1038/s41598-017-10506-8.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr5179836587Silentrs11548636P439P0.45
BLCAchr5179825156Silentrs751263705P228P0.28
BLCAchr5179836460Missense_MutationnovelS397F0.1
BLCAchr5179833685SilentnovelL356L0.43
BLCAchr5179822954Splice_Regionrs3707781980.14
BLCAchr5179836552SilentNAL428L0.3
BLCAchr5179820944Missense_Mutationrs777501273S3L0.27
BLCAchr5179824010Missense_MutationNAS152C0.34
BLCAchr51798372683'UTRnovel0.2
BRCAchr51798369103'UTRnovel0.2
BRCAchr5179836500Silentrs766437927G410G0.27
BRCAchr5179824050Missense_MutationNAK165R0.6
BRCAchr5179833248Splice_SiteNAX323_splice0.43
BRCAchr5179822734Intronnovel0.5
BRCAchr5179836530Missense_MutationNAK420N0.1
BRCAchr5179833660Missense_Mutationrs772889843P348L0.41
BRCAchr5179823877Frame_Shift_DelnovelD108Pfs*420.18
BRCAchr5179824021Missense_MutationnovelE155D0.29
CESCchr5179833621In_Frame_DelnovelD336_H340del0.08
CESCchr5179822922Intronnovel0.09
CESCchr5179833716Missense_MutationNAL367V0.26
COADchr5179824207Missense_Mutationrs778537429R186Q0.5
COADchr5179824037Missense_Mutationrs758625124R161W0.31
COADchr5179833127Missense_MutationnovelS284A0.39
COADchr5179836542Silentrs374985304I424I0.07
COADchr5179824037Missense_Mutationrs758625124R161W0.17
COADchr5179836448Missense_Mutationrs200551825R393Q0.09
COADchr51798366033'UTRnovel0.38
ESCAchr5179833710Missense_MutationnovelS365C0.13
GBMchr5179823039Missense_Mutationrs569811115R96Q0.24
GBMchr5179824229Missense_MutationnovelF193L0.15
GBMchr51798367503'UTRnovel0.44
GBMchr51798372483'UTRnovel0.46
GBMchr51798372613'UTRnovel0.1
HNSCchr5179833066Silentrs200889080G263G0.05
KICHchr5179833234Splice_SitenovelX320_splice0.71
KIRPchr51798209355'UTRrs7551728410.35
KIRPchr5179823983Missense_MutationNAS143C0.43
LGGchr5179823876Missense_MutationNAR107Q0.46
LIHCchr5179833608Missense_MutationnovelC331S0.11
LUADchr51798366653'UTRnovel0.56
LUADchr5179824054Silentrs372518286L166L0.14
LUADchr5179822978Missense_MutationNAA76S0.13
LUADchr5179823885Missense_MutationNAR110L0.29
LUADchr5179833106Missense_MutationNAS277G0.21
LUADchr5179824243Nonsense_MutationNAW198*0.21
LUADchr5179823038Nonsense_MutationNAR96*0.92
LUSCchr5179833716SilentnovelL367L0.23
LUSCchr5179824262SilentnovelG204G0.21
LUSCchr5179822985Missense_MutationNAS78F0.87
LUSCchr5179820937Translation_Start_SiteNAM1?0.89
OVchr5179824006SilentNAL150L0.35
OVchr5179836505Missense_MutationnovelW412S0.07
OVchr5179836505Missense_MutationnovelW412L0.04
PAADchr5179833104Missense_Mutationrs202119215S276Y0.25
PAADchr5179833107Missense_MutationnovelS277I0.14
PAADchr5179825186Missense_MutationnovelK238N0.26
PAADchr5179820944Missense_Mutationrs777501273S3L0.08
READchr5179836547Missense_Mutationrs201239306A426V0.19
READchr5179823876Missense_MutationNAR107Q0.43
READchr51798366773'UTRnovel0.38
SKCMchr5179825196Missense_MutationNAE242K0.46
SKCMchr5179822968Silentrs757587948G72G0.15
SKCMchr5179823931Missense_MutationNAN125K0.28
SKCMchr5179825214Missense_MutationnovelL248F0.42
SKCMchr5179824261Missense_MutationNAG204E0.64
SKCMchr51798366083'UTRnovel0.25
SKCMchr5179822887Intronnovel0.22
SKCMchr5179833650Missense_MutationNAE345K0.27
SKCMchr5179836543Missense_Mutationrs757212984G425R0.17
STADchr5179825155Missense_Mutationrs151191977P228L0.31
STADchr5179823884Missense_Mutationrs139372286R110C0.24
STADchr5179823925Frame_Shift_DelnovelN125Mfs*20.34
STADchr5179824252Missense_MutationNAG201D0.11
STADchr51798372443'UTRnovel0.48
STADchr5179833189Silentrs370970067T304T0.26
STADchr5179833239Missense_Mutationrs752889531R321H0.38
STADchr5179823039Missense_Mutationrs569811115R96Q0.27
STADchr5179833040Missense_Mutationrs182522590V255I0.24
STADchr5179823912Missense_Mutationrs779807674R119H0.29
STADchr5179836587Silentrs11548636P439P0.38
STADchr5179836532Missense_MutationNAN421S0.24
STADchr5179823014Missense_MutationNAS88P0.21
STADchr5179833083Frame_Shift_DelnovelV271Sfs*410.49
UCECchr5179824198Missense_Mutationrs535606152R183H0.11
UCECchr5179836450SilentnovelL394L0.19
UCECchr51798366163'UTRnovel0.42
UCECchr51798372223'UTRnovel0.41
UCECchr5179824239Nonsense_MutationnovelG197*0.48
UCECchr5179836525Missense_MutationnovelT419A0.06
UCECchr5179824073Missense_Mutationrs200731802G173R0.53
UCECchr5179824268Missense_MutationnovelW206C0.43
UCECchr5179823982SilentNAC142C0.17
UCECchr5179825223Missense_MutationnovelL251M0.24
UCECchr51798366543'UTRrs7504232300.2
UCECchr5179823872Missense_MutationnovelR106W0.5
UCECchr5179823038Nonsense_MutationNAR96*0.16
UCECchr51798369133'UTRnovel0.67
UCECchr5179824229Silentrs527602F193F0.41
UCECchr5179833660Missense_Mutationrs772889843P348L0.28
UCECchr5179836542Silentrs374985304I424I0.42
UCECchr51798367853'UTRrs112496600.55
UCECchr5179824276Missense_MutationNAR209H0.41
UCECchr51798372723'UTRnovel0.38
UCECchr5179823912Missense_Mutationrs779807674R119H0.3
UCECchr51798371183'UTRnovel0.72
UCECchr51798372723'UTRnovel0.3
UCECchr5179833075Missense_MutationnovelS266R0.23
UCECchr5179836583Missense_Mutationrs759646319P438L0.24
UCECchr5179836542Silentrs374985304I424I0.04
UCECchr5179833033Splice_Regionrs769297000G252G0.55
UCECchr5179833192SilentnovelQ305Q0.21
UCECchr5179833600Missense_Mutationrs763767102S328L0.32
UCECchr5179836500Silentrs766437927G410G0.28
UCECchr5179824000Silentrs769497182Y148Y0.38
UCECchr5179823960Missense_MutationNAV135A0.24
UCSchr5179836548Silentrs143977783A426A0.04
UCSchr5179824284Missense_Mutationrs201263163R212C0.42
UVMchr5179824203Missense_Mutationrs753313263L185F0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCAMP0.5892.1944e-60
KIRPAMP0.11460.069756
KIRPDEL0.03470.11554
LUADAMP0.18020.24967
LUSCDEL0.59080.002071
MESODEL0.11490.20184
PRADAMP0.03460.16448
SKCMAMP0.12810.23703
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
THYM0.01

Kaplan-Meier Survival Analysis

SARC0.00028

Kaplan-Meier Survival Analysis

ACC0.00025

Kaplan-Meier Survival Analysis

TGCT0.019

Kaplan-Meier Survival Analysis

KIRP0.00027

Kaplan-Meier Survival Analysis

GBM0.0097

Kaplan-Meier Survival Analysis

LIHC0.0056

Kaplan-Meier Survival Analysis

DLBC0.008

Kaplan-Meier Survival Analysis

UVM0.0052

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000161011 (Gene tree)
Gene ID
8878
Gene Symbol
SQSTM1
Alias
p62|p60|p62B|A170|PDB3|OSIL
Full Name
sequestosome 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
31,691 bases
Position
chr5:179,806,388-179,838,078
Accession
11280
RBP type
non-canonical RBP
Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26032484Frontotemporal lobar dementia and amyotrophic lateral sclerosis associated with c9orf72 expansion.Rev Neurol (Paris)2015 Jun-JulLe Ber Idoi: 10.1016/j.neurol.2015.04.004
30939964Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.Autophagy2019 Apr 2:1-19Catanese Adoi: 10.1080/15548627.2019.1589257
29302778A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism.Acta Neuropathol2018 MarSwinnen Bdoi: 10.1007/s00401-017-1796-5
27632209Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients.PLoS One2016 Sep 15Guven Gdoi: 10.1371/journal.pone.0162592
8720131Phosphorylation of HS1, GAP-associated p190 and a novel GAP-associated p60 protein by cross-linking of Fc gamma RIIIA.J Biochem1995 DecZeng H-
7816614Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway.Nucleic Acids Res1994 Dec 11Braddock M-
12849008Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma.Autoimmun Rev2002 MayZhang J-
25086041PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.J Biol Chem2014 Sep 19Welsby Idoi: 10.1074/jbc.M114.589515
24085347Amyotrophic lateral sclerosis: an update on recent genetic insights.J Neurol2013 NovIguchi Ydoi: 10.1007/s00415-013-7112-y
24090760The clinical and pathological phenotypes of frontotemporal dementia with C9ORF72 mutations.J Neurol Sci2013 Dec 15Liu Ydoi: 10.1016/j.jns.2013.09.013
27066560Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation.Neurol Genet2015 Sep 24Izumi Rdoi: 10.1212/NXG.0000000000000023
30281815DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1.Hepatology2019 MarZhang Hdoi: 10.1002/hep.30300
30581152p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.Cancer Cell2019 Jan 14Karras Pdoi: 10.1016/j.ccell.2018.11.008
31000784RNA binding to p62 impacts selective autophagy.Cell Res2019 JulMisra Mdoi: 10.1038/s41422-019-0167-2.
31006338Vault RNA emerges as a regulator of selective autophagy.Autophagy2019 AugHoros Rdoi: 10.1080/15548627.2019.1609861
31142229Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.Autophagy2019 May 29:1-17Ivankovic Ddoi: 10.1080/15548627.2019.1615302
31234698Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.Autophagy2019 Jun 24:1-19Jung Sdoi: 10.1080/15548627.2019.1630222
31238788PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.Autophagy2019 Jun 25:1-20Sarkar Cdoi: 10.1080/15548627.2019.1628538
30209975Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.Autophagy2019 JanYau WWdoi: 10.1080/15548627.2018.1511263
29105510MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice.Exp Biol Med (Maywood)2018 JanHuang YHdoi: 10.1177/1535370217741500
29130360Autophagy and innate immunity: Insights from invertebrate model organisms.Autophagy2018Kuo CJdoi: 10.1080/15548627.2017.1389824
24705402Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy.Diabetes2014 JunZhang MZdoi: 10.2337/db13-1279
30982460HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.Autophagy2019 Apr 14:1-18Neubert Pdoi: 10.1080/15548627.2019.1596483
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000512234SQSTM1-2141722--- (aa)--
ENST00000453046SQSTM1-204572-ENSP0000040506173 (aa)-C9J6J8
ENST00000510187SQSTM1-2131714-ENSP00000424477378 (aa)-E7EMC7
ENST00000506690SQSTM1-2112405--- (aa)--
ENST00000481335SQSTM1-207562--- (aa)--
ENST00000514093SQSTM1-215842-ENSP00000427308167 (aa)-E9PFW8
ENST00000464493SQSTM1-205532--- (aa)--
ENST00000422245SQSTM1-203628-ENSP00000394534140 (aa)-C9JRJ8
ENST00000360718SQSTM1-2012253XM_017010010ENSP00000353944356 (aa)XP_016865499Q13501
ENST00000506042SQSTM1-210921--- (aa)--
ENST00000626660SQSTM1-216274-ENSP0000048707173 (aa)-C9J6J8
ENST00000466342SQSTM1-206808--- (aa)--
ENST00000389805SQSTM1-2022986-ENSP00000374455440 (aa)-Q13501
ENST00000508284SQSTM1-212578-ENSP0000042419569 (aa)-D6RBF1
ENST00000504627SQSTM1-209602-ENSP00000425957190 (aa)-E3W990
ENST00000485412SQSTM1-208656--- (aa)--
Gene Model
Click here to download ENSG00000161011's gene model file
Pathways
Pathway IDPathway NameSource
hsa04137Mitophagy - animalKEGG
hsa04217NecroptosisKEGG
hsa04218Cellular senescenceKEGG
hsa04380Osteoclast differentiationKEGG
hsa05418Fluid shear stress and atherosclerosisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000161011Hemoglobin A, Glycosylated6.0230000E-00519875614
ENSG00000161011Child Development Disorders, Pervasive7.3000000E-005-
ENSG00000161011Alzheimer Disease7E-724162737
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000161011rs728073435179811261TAlzheimer's disease (late onset)24162737[1.20-1.52]1.35EFO_0000249
ENSG00000161011rs105161405179813910?Red cell distribution width30595370EFO_0005192
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161011's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000161011SQSTM110092.143ENSMUSG00000015837Sqstm110089.819Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-IEAProcess
GO:0000407phagophore assembly site-IEAComponent
GO:0000422autophagy of mitochondrion20098416.NASProcess
GO:0000423mitophagy21873635.IBAProcess
GO:0000423mitophagy20457763.IGIProcess
GO:0000932P-body20357094.IDAComponent
GO:0001934positive regulation of protein phosphorylation-IEAProcess
GO:0002376immune system process-IEAProcess
GO:0002931response to ischemia-IEAProcess
GO:0004674protein serine/threonine kinase activity8618896.NASFunction
GO:0005080protein kinase C binding21873635.IBAFunction
GO:0005080protein kinase C binding14676191.IPIFunction
GO:0005515protein binding8618896.8702753.14676191.16169070.16189514.16874300.17389358.17580304.18083104.19229298.19250911.19427866.19615732.20010802.20168092.20173742.20357094.20417604.20452972.20551902.20562859.20808283.21149568.21900206.21988832.22178386.22190034.22421968.23274085.23459205.24089205.24189400.24316673.24668264.24879152.25026213.25040165.25126726.25416956.25422469.25686248.25910212.26344566.26347139.26524528.27103069.27728806.28404643.IPIFunction
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm20168092.IDAComponent
GO:0005739mitochondrion-IEAComponent
GO:0005770late endosome-IEAComponent
GO:0005776autophagosome21873635.IBAComponent
GO:0005776autophagosome17580304.19640926.20168092.22948227.24954904.IDAComponent
GO:0005783endoplasmic reticulum-IEAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol8650207.TASComponent
GO:0006468protein phosphorylation-IEAProcess
GO:0006511ubiquitin-dependent protein catabolic process8702753.TASProcess
GO:0006914autophagy17580304.IMPProcess
GO:0006914autophagy19816510.TASProcess
GO:0006915apoptotic process-IEAProcess
GO:0007005mitochondrion organization21873635.IBAProcess
GO:0007032endosome organization21873635.IBAProcess
GO:0007032endosome organization27368102.IDAProcess
GO:0008104protein localization8650207.TASProcess
GO:0008270zinc ion binding-IEAFunction
GO:0010821regulation of mitochondrion organization20890124.NASProcess
GO:0016197endosomal transport12857745.TASProcess
GO:0016234inclusion body20168092.IDAComponent
GO:0016235aggresome21873635.IBAComponent
GO:0016236macroautophagy20168092.IMPProcess
GO:0016236macroautophagy-ISSProcess
GO:0016236macroautophagy-TASProcess
GO:0016605PML body20168092.IDAComponent
GO:0019899enzyme binding27368102.IPIFunction
GO:0019901protein kinase binding8650207.IDAFunction
GO:0030017sarcomere-IEAComponent
GO:0030154cell differentiation-IEAProcess
GO:0030971receptor tyrosine kinase binding8650207.TASFunction
GO:0031625ubiquitin protein ligase binding27368102.IDAFunction
GO:0031625ubiquitin protein ligase binding25127057.27368102.IPIFunction
GO:0035255ionotropic glutamate receptor binding-ISSFunction
GO:0035556intracellular signal transduction8650207.TASProcess
GO:0035973aggrephagy21873635.IBAProcess
GO:0035973aggrephagy28404643.IPIProcess
GO:0042169SH2 domain binding8650207.IDAFunction
GO:0042802identical protein binding16169070.20562859.21900206.25416956.25686248.IPIFunction
GO:0042803protein homodimerization activity-IEAFunction
GO:0043065positive regulation of apoptotic process-TASProcess
GO:0043066negative regulation of apoptotic process-TASProcess
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling12857745.IMPProcess
GO:0043130ubiquitin binding12857745.IDAFunction
GO:0043130ubiquitin binding-TASFunction
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0044130negative regulation of growth of symbiont in host-IEAProcess
GO:0044753amphisome21873635.IBAComponent
GO:0044753amphisome19640926.IDAComponent
GO:0044754autolysosome19640926.IDAComponent
GO:0045944positive regulation of transcription by RNA polymerase II12857745.TASProcess
GO:0046578regulation of Ras protein signal transduction8618896.NASProcess
GO:0051291protein heterooligomerization-IEAProcess
GO:0061635regulation of protein complex stability25127057.IDAProcess
GO:0061912selective autophagy22622177.IMPProcess
GO:0070062extracellular exosome19056867.HDAComponent
GO:0070498interleukin-1-mediated signaling pathway-TASProcess
GO:0070530K63-linked polyubiquitin modification-dependent protein binding21873635.IBAFunction
GO:0070530K63-linked polyubiquitin modification-dependent protein binding28404643.IDAFunction
GO:0097225sperm midpiece-IEAComponent
GO:0097413Lewy body-IEAComponent
GO:0098780response to mitochondrial depolarisation20457763.IGIProcess
GO:1900273positive regulation of long-term synaptic potentiation-ISSProcess
GO:1903078positive regulation of protein localization to plasma membrane-ISSProcess
GO:1905719protein localization to perinuclear region of cytoplasm27368102.IDAProcess
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