EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29278882	Serine/arginine rich splicing factor 2 expression and clinic pathological features indicating a prognostic factor in human hepatocellular carcinoma patients.	Cancer Biomark	2018 Feb 14	Wang P	doi: 10.3233/CBM-170770.
25717103	Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35).	J Virol	2015 May	McFarlane M	doi: 10.1128/JVI.03434-14
26257065	Genome-wide lentiviral shRNA screen identifies serine/arginine-rich splicing factor 2 as a determinant of oncolytic virus activity in breast cancer cells.	Oncogene	2016 May 12	Workenhe ST	doi: 10.1038/onc.2015.303
28082404	SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development.	Cancer Res	2017 Mar 1	Luo C	doi: 10.1158/0008-5472.CAN-16-1919

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	76736327	Missense_Mutation	NA	R167Q	0.2
BLCA	chr17	76736088	Intron	novel		0.26
BLCA	chr17	76736441	Missense_Mutation	NA	R129L	0.15
BLCA	chr17	76736088	Intron	novel		0.2
BLCA	chr17	76736184	Missense_Mutation	novel	E215K	0.19
BLCA	chr17	76737084	Nonsense_Mutation	NA	S26*	0.25	RRM_1
BLCA	chr17	76736213	Missense_Mutation	NA	R205L	0.26
BLCA	chr17	76736209	Silent	novel	S206S	0.08
BRCA	chr17	76734871	3'UTR	novel		0.16
BRCA	chr17	76734643	3'UTR	novel		0.42
BRCA	chr17	76735802	Intron	novel		0.2
BRCA	chr17	76737005	Missense_Mutation	NA	K52N	0.27	RRM_1
BRCA	chr17	76734405	3'UTR	novel		0.13
BRCA	chr17	76736420	Missense_Mutation	NA	S136C	0.26
BRCA	chr17	76736996	Silent	novel	R55R	0.2
CESC	chr17	76735094	3'UTR	novel		0.33
CESC	chr17	76736956	Missense_Mutation	NA	E69K	0.19	RRM_1
CESC	chr17	76735703	Intron	novel		0.41
CESC	chr17	76736956	Missense_Mutation	NA	E69K	0.55	RRM_1
CESC	chr17	76735100	3'UTR	novel		0.17
CESC	chr17	76734894	3'UTR	novel		0.5
CESC	chr17	76736990	Silent	rs376379121	F57F	0.47
CESC	chr17	76736434	Silent	NA	R131R	0.69
CESC	chr17	76736850	Missense_Mutation	NA	G104E	0.85
COAD	chr17	76734866	3'UTR	novel		0.15
COAD	chr17	76737018	Missense_Mutation	novel	D48G	0.45	RRM_1
COAD	chr17	76734315	3'UTR	novel		0.31
COAD	chr17	76734866	3'UTR	novel		0.34
COAD	chr17	76734891	3'UTR	novel		0.18
ESCA	chr17	76734582	3'UTR	novel		0.54
ESCA	chr17	76736877	Missense_Mutation	rs751713049	P95L	0.15
ESCA	chr17	76734866	3'UTR	novel		0.4
GBM	chr17	76736202	Missense_Mutation	NA	P209T	0.08
HNSC	chr17	76736428	Silent	novel	R133R	0.42
HNSC	chr17	76737021	Missense_Mutation	novel	R47L	0.18	RRM_1
HNSC	chr17	76737138	Frame_Shift_Ins	novel	*P8Lfs7**	0.39
HNSC	chr17	76736442	Missense_Mutation	novel	R129G	0.11
HNSC	chr17	76736327	Missense_Mutation	novel	R167L	0.19
LAML	chr17	76736877	Missense_Mutation	rs751713049	P95L	0.5
LIHC	chr17	76734714	3'UTR	novel		0.13
LIHC	chr17	76734883	3'UTR	novel		0.42
LUAD	chr17	76736175	Missense_Mutation	novel	A218T	0.06
LUAD	chr17	76736832	Missense_Mutation	NA	Y110C	0.3
LUAD	chr17	76736136	Intron	rs374140173		0.11
LUAD	chr17	76736324	Missense_Mutation	NA	R168K	0.17
LUAD	chr17	76736921	Silent	novel	L80L	0.22
LUAD	chr17	76736873	Frame_Shift_Ins	rs754601892	*D97Gfs27**	0.13
LUSC	chr17	76737058	Missense_Mutation	novel	E35K	0.19	RRM_1
LUSC	chr17	76736342	Missense_Mutation	novel	K162R	0.42
LUSC	chr17	76736233	Frame_Shift_Del	novel	S196*	0.32
LUSC	chr17	76736291	Missense_Mutation	NA	S179C	0.21
LUSC	chr17	76736984	Silent	NA	F59F	0.3
OV	chr17	76735855	Intron	novel		0.75
OV	chr17	76735857	Intron	novel		0.75
OV	chr17	76735583	Intron	novel		0.79
PRAD	chr17	76736351	In_Frame_Del	rs760875189	R152_S159del	0.14
PRAD	chr17	76736208	Nonsense_Mutation	NA	K207*	0.03
PRAD	chr17	76736209	Silent	NA	S206S	0.04
READ	chr17	76736267	Missense_Mutation	novel	S187Y	0.52
SARC	chr17	76734499	3'UTR	novel		1
SKCM	chr17	76737117	Missense_Mutation	NA	S15F	0.3
SKCM	chr17	76736227	Silent	novel	S200S	0.5
SKCM	chr17	76736228	Missense_Mutation	NA	S200F	0.5
SKCM	chr17	76736382	Missense_Mutation	NA	S149P	0.52
SKCM	chr17	76736881	Missense_Mutation	NA	R94C	0.27
STAD	chr17	76736874	Frame_Shift_Del	NA	*P96Rfs136**	0.3
STAD	chr17	76736260	In_Frame_Ins	novel	R190_S191dup	0.13
STAD	chr17	76736874	Frame_Shift_Del	NA	*P96Rfs136**	0.26
STAD	chr17	76736911	Missense_Mutation	novel	E84K	0.31	RRM_1
STAD	chr17	76736100	Intron	novel		0.12
UCEC	chr17	76735646	Intron	novel		0.23
UCEC	chr17	76737160	Translation_Start_Site	novel	M1?	0.24
UCEC	chr17	76734314	3'UTR	novel		0.28
UCEC	chr17	76735539	Intron	novel		0.34
UCEC	chr17	76734408	3'UTR	novel		0.14
UCEC	chr17	76735552	Intron	novel		0.31
UCEC	chr17	76736196	Missense_Mutation	novel	K211E	0.36
UCEC	chr17	76734226	3'UTR	novel		0.15
UCEC	chr17	76737141	Frame_Shift_Del	novel	*P7Lfs7**	0.16
UCEC	chr17	76734604	3'UTR	novel		0.36
UCEC	chr17	76736357	Missense_Mutation	novel	S157Y	0.1
UCEC	chr17	76734566	3'UTR	novel		0.17
UCEC	chr17	76735118	3'UTR	novel		0.6
UCEC	chr17	76736402	Missense_Mutation	rs755334722	S142F	0.44
UCEC	chr17	76734688	3'UTR	novel		0.44
UCEC	chr17	76736228	Missense_Mutation	NA	S200F	0.3
UCEC	chr17	76737132	Missense_Mutation	novel	V10A	0.43
UVM	chr17	76736861	In_Frame_Del	novel	Y92_H100del	0.24
UVM	chr17	76736291	In_Frame_Del	novel	S174_S179del	0.18
UVM	chr17	76736864	In_Frame_Del	novel	Y92_H99del	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3873	0.00012456
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0663	1.52e-05
LUSC	AMP	0.3453	0.001059
SARC	AMP	0.2218	0.032181
SKCM	AMP	0.2916	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.15	0.054583

Survival Analysis

Cancer	P-value	Q-value
THYM	0.008	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.0071	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.047	Kaplan-Meier Survival Analysis
PRAD	0.0078	Kaplan-Meier Survival Analysis
ESCA	0.017	Kaplan-Meier Survival Analysis
KIRP	0.026	Kaplan-Meier Survival Analysis
COAD	0.023	Kaplan-Meier Survival Analysis
BLCA	0.0005	Kaplan-Meier Survival Analysis
CESC	0.0017	Kaplan-Meier Survival Analysis
READ	0.0026	Kaplan-Meier Survival Analysis
KICH	0.032	Kaplan-Meier Survival Analysis
UCEC	0.022	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.03	Kaplan-Meier Survival Analysis
UVM	0.0047	Kaplan-Meier Survival Analysis
OV	0.0027	Kaplan-Meier Survival Analysis

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000161547 (Gene tree)
Gene ID: 6427
Gene Symbol: SRSF2
Alias: SC-35|SC35|PR264|SFRS2A|SFRS2
Full Name: serine and arginine rich splicing factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 3,515 bases
Position: chr17:76,734,115-76,737,629
Accession: 10783
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000463317	RRM_1	PF00076.22	6.4e-22	1	1
ENSP00000350877	RRM_1	PF00076.22	6.7e-22	1	1
ENSP00000441780	RRM_1	PF00076.22	1.7e-21	1	1
ENSP00000353089	RRM_1	PF00076.22	1.9e-21	1	1
ENSP00000376276	RRM_1	PF00076.22	1.9e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27577262	Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells.	Sci Signal	2016 Aug 30	Larsen SC	doi: 10.1126/scisignal.aaf7329.
21249130	Gadd45a is an RNA binding protein and is localized in nuclear speckles.	PLoS One	2011 Jan 7	Sytnikova YA	doi: 10.1371/journal.pone.0014500.
26965252	Characterization of RNA-Protein Interactions: Lessons from Two RNA-Binding Proteins, SRSF1 and SRSF2.	Methods Mol Biol	2016	Skrdlant L	doi: 10.1007/978-1-4939-3591-8_1.
29395063	The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.	Mol Cell	2018 Feb 1	Chen L	doi: 10.1016/j.molcel.2017.12.029
29433383	Mycobacterium tuberculosis H37Rv infection regulates alternative splicing in Macrophages.	Bioengineered	2018 Jan 1	Zhang W	doi: 10.1080/21655979.2017.1387692.
31124956	Effect of RNA splicing machinery gene mutations on prognosis of patients with MDS: A meta-analysis.	Medicine (Baltimore)	2019 May	Wang X	doi: 10.1097/MD.0000000000015743.
12962546	Genome-wide prediction, display and refinement of binding sites with information theory-based models.	BMC Bioinformatics	2003 Sep 8	Gadiraju S	-
28082404	SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development.	Cancer Res	2017 Mar 1	Luo C	doi: 10.1158/0008-5472.CAN-16-1919
7543047	The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.	EMBO J	1995 Jul 17	Tacke R	-
9761791	The plant U1 small nuclear ribonucleoprotein particle 70K protein interacts with two novel serine/arginine-rich proteins.	Plant Cell	1998 Oct	Golovkin M	-
8610170	Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors.	Proc Natl Acad Sci U S A	1996 Apr 2	Lopato S	-
8013463	Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.	EMBO J	1994 Jun 1	Cavaloc Y	-
21683323	Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement.	Am J Hum Genet	2011 Jul 15	Kobayashi H	doi: 10.1016/j.ajhg.2011.05.015
20800907	Common variation in the MOG gene influences transcript splicing in humans.	J Neuroimmunol	2010 Dec 15	Jensen CJ	doi: 10.1016/j.jneuroim.2010.07.027
20547768	Vitamin A metabolite, all-trans-retinoic acid, mediates alternative splicing of protein kinase C deltaVIII (PKCdeltaVIII) isoform via splicing factor SC35.	J Biol Chem	2010 Aug 20	Apostolatos H	doi: 10.1074/jbc.M110.100735
25412662	FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.	Cell Res	2014 Dec	Zhao X	doi: 10.1038/cr.2014.151
24428911	A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies.	Mol Cancer	2014 Jan 15	Pesson M	doi: 10.1186/1476-4598-13-9.
25965569	SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.	Cancer Cell	2015 May 11	Kim E	doi: 10.1016/j.ccell.2015.04.006.
24290757	Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic.	Cell Rep	2013 Dec 12	Lee YB	doi: 10.1016/j.celrep.2013.10.049
27552991	Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C.	BMC Mol Biol	2016 Aug 23	Skrdlant L	doi: 10.1186/s12867-016-0071-y.
26261309	Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.	Proc Natl Acad Sci U S A	2015 Aug 25	Zhang J	doi: 10.1073/pnas.1514105112
25889056	Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication.	Retrovirology	2015 Mar 28	Erkelenz S	doi: 10.1186/s12977-015-0154-8.
29858584	SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.	Leukemia	2018 Dec	Liang Y	doi: 10.1038/s41375-018-0152-7
24406341	Unique role of SRSF2 in transcription activation and diverse functions of the SR and hnRNP proteins in gene expression regulation.	Transcription	2013 Sep-Dec	Mo S	-
19648116	Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35.	J Biol Chem	2009 Sep 18	Fan C	doi: 10.1074/jbc.M109.041368
23663783	SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.	Cell	2013 May 9	Ji X	doi: 10.1016/j.cell.2013.04.028.
22002536	A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well.	EMBO J	2012 Jan 4	Daubner GM	doi: 10.1038/emboj.2011.367

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000589919	SRSF2-210	595	-	-	- (aa)	-	-
ENST00000452355	SRSF2-204	1357	-	ENSP00000391278	221 (aa)	-	Q01130
ENST00000583836	SRSF2-207	561	-	ENSP00000463317	130 (aa)	-	J3QL05
ENST00000585202	SRSF2-208	1359	-	ENSP00000462425	221 (aa)	-	Q01130
ENST00000586778	SRSF2-209	1001	-	-	- (aa)	-	-
ENST00000508921	SRSF2-205	1390	-	ENSP00000441780	209 (aa)	-	Q01130
ENST00000358156	SRSF2-201	572	-	ENSP00000350877	133 (aa)	-	J3KP15
ENST00000392485	SRSF2-203	2885	XM_017024942	ENSP00000376276	221 (aa)	XP_016880431	Q01130
ENST00000359995	SRSF2-202	1927	-	ENSP00000353089	221 (aa)	-	Q01130
ENST00000592676	SRSF2-211	559	-	-	- (aa)	-	-
ENST00000582449	SRSF2-206	1518	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000161547's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000161547	Corneal Pachymetry	2E-10	23776548

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000161547	rs3744061	17	76737321	G	Retinal arteriolar caliber	23776548	[0.61-1.11] unit decrease	0.86	EFO_0004731

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161547's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000161547	SRSF2	68	33.708	ENSG00000132819	RBM38	70	34.884
ENSG00000161547	SRSF2	75	30.233	ENSG00000179950	PUF60	52	30.769
ENSG00000161547	SRSF2	65	39.130	ENSG00000115875	SRSF7	66	39.130
ENSG00000161547	SRSF2	61	32.911	ENSG00000090621	PABPC4	61	32.911
ENSG00000161547	SRSF2	70	32.500	ENSG00000066044	ELAVL1	52	32.500
ENSG00000161547	SRSF2	58	44.000	ENSG00000147274	RBMX	79	45.161
ENSG00000161547	SRSF2	82	78.302	ENSG00000263465	SRSF8	52	58.108
ENSG00000161547	SRSF2	89	39.894	ENSG00000188529	SRSF10	80	46.667
ENSG00000161547	SRSF2	71	41.053	ENSG00000099622	CIRBP	90	47.222
ENSG00000161547	SRSF2	58	44.000	ENSG00000213516	RBMXL1	56	41.573
ENSG00000161547	SRSF2	55	31.507	ENSG00000205937	RNPS1	52	34.328
ENSG00000161547	SRSF2	70	32.468	ENSG00000107105	ELAVL2	79	32.468
ENSG00000161547	SRSF2	62	34.118	ENSG00000135486	HNRNPA1	54	34.118
ENSG00000161547	SRSF2	78	38.235	ENSG00000242389	RBMY1E	79	36.923
ENSG00000161547	SRSF2	59	32.468	ENSG00000130811	EIF3G	53	33.871
ENSG00000161547	SRSF2	78	38.235	ENSG00000244395	RBMY1D	79	36.923
ENSG00000161547	SRSF2	55	32.877	ENSG00000151923	TIAL1	54	32.394
ENSG00000161547	SRSF2	61	32.432	ENSG00000070756	PABPC1	67	31.646
ENSG00000161547	SRSF2	78	38.235	ENSG00000242875	RBMY1B	79	36.923
ENSG00000161547	SRSF2	57	32.432	ENSG00000114503	NCBP2	54	32.432
ENSG00000161547	SRSF2	78	38.235	ENSG00000234414	RBMY1A1	79	36.923
ENSG00000161547	SRSF2	72	35.106	ENSG00000112081	SRSF3	55	38.356

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000161547	SRSF2	82	95.327	ENSAPOG00000024396	srsf2a	59	78.358	Acanthochromis_polyacanthus
ENSG00000161547	SRSF2	77	94.000	ENSAPOG00000008073	srsf2b	64	72.464	Acanthochromis_polyacanthus
ENSG00000161547	SRSF2	63	100.000	ENSAMEG00000013624	-	78	66.667	Ailuropoda_melanoleuca
ENSG00000161547	SRSF2	82	95.327	ENSACIG00000018502	srsf2a	74	85.039	Amphilophus_citrinellus
ENSG00000161547	SRSF2	77	95.000	ENSAOCG00000022441	-	67	75.524	Amphiprion_ocellaris
ENSG00000161547	SRSF2	86	93.860	ENSAOCG00000021878	srsf2a	61	77.612	Amphiprion_ocellaris
ENSG00000161547	SRSF2	86	93.860	ENSAPEG00000023494	srsf2a	61	77.612	Amphiprion_percula
ENSG00000161547	SRSF2	77	95.000	ENSAPEG00000006375	-	63	74.815	Amphiprion_percula
ENSG00000161547	SRSF2	100	99.095	ENSACAG00000008553	-	100	99.095	Anolis_carolinensis
ENSG00000161547	SRSF2	72	84.043	ENSANAG00000031642	SRSF8	57	57.325	Aotus_nancymaae
ENSG00000161547	SRSF2	100	100.000	ENSANAG00000004226	SRSF2	100	100.000	Aotus_nancymaae
ENSG00000161547	SRSF2	77	95.000	ENSACLG00000017862	srsf2b	62	75.373	Astatotilapia_calliptera
ENSG00000161547	SRSF2	85	94.690	ENSACLG00000027016	srsf2a	61	78.102	Astatotilapia_calliptera
ENSG00000161547	SRSF2	100	100.000	ENSBTAG00000018258	SRSF2	100	100.000	Bos_taurus
ENSG00000161547	SRSF2	67	63.218	ENSBTAG00000050905	-	51	63.218	Bos_taurus
ENSG00000161547	SRSF2	72	60.215	WBGene00004701	rsp-4	74	60.215	Caenorhabditis_elegans
ENSG00000161547	SRSF2	100	100.000	ENSCJAG00000041154	SRSF2	100	100.000	Callithrix_jacchus
ENSG00000161547	SRSF2	100	99.548	ENSCAFG00000005147	SRSF2	100	99.548	Canis_familiaris
ENSG00000161547	SRSF2	100	100.000	ENSCAFG00020006267	-	100	100.000	Canis_lupus_dingo
ENSG00000161547	SRSF2	100	100.000	ENSCHIG00000017001	-	100	100.000	Capra_hircus
ENSG00000161547	SRSF2	100	83.439	ENSTSYG00000006517	-	71	83.439	Carlito_syrichta
ENSG00000161547	SRSF2	100	99.095	ENSCCAG00000037532	SRSF2	100	99.095	Cebus_capucinus
ENSG00000161547	SRSF2	72	82.979	ENSCATG00000018279	SRSF8	51	62.069	Cercocebus_atys
ENSG00000161547	SRSF2	100	100.000	ENSCATG00000033650	SRSF2	100	100.000	Cercocebus_atys
ENSG00000161547	SRSF2	100	90.909	ENSCLAG00000012450	-	100	90.909	Chinchilla_lanigera
ENSG00000161547	SRSF2	100	100.000	ENSCSAG00000005108	SRSF2	100	100.000	Chlorocebus_sabaeus
ENSG00000161547	SRSF2	100	100.000	ENSCPBG00000027975	-	100	100.000	Chrysemys_picta_bellii
ENSG00000161547	SRSF2	71	80.435	ENSCING00000004198	-	57	78.723	Ciona_intestinalis
ENSG00000161547	SRSF2	71	81.522	ENSCSAVG00000009199	-	53	79.787	Ciona_savignyi
ENSG00000161547	SRSF2	100	100.000	ENSCANG00000028176	SRSF2	100	100.000	Colobus_angolensis_palliatus
ENSG00000161547	SRSF2	72	82.979	ENSCANG00000028971	-	60	58.442	Colobus_angolensis_palliatus
ENSG00000161547	SRSF2	100	100.000	ENSCGRG00001023483	Srsf2	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000161547	SRSF2	82	94.393	ENSCVAG00000022056	srsf2a	58	77.612	Cyprinodon_variegatus
ENSG00000161547	SRSF2	90	94.167	ENSDARG00000057484	srsf2a	85	96.000	Danio_rerio
ENSG00000161547	SRSF2	100	100.000	ENSDNOG00000000439	-	100	100.000	Dasypus_novemcinctus
ENSG00000161547	SRSF2	72	100.000	ENSDORG00000014460	Srsf2	51	93.269	Dipodomys_ordii
ENSG00000161547	SRSF2	73	80.000	ENSEBUG00000008729	-	72	60.839	Eptatretus_burgeri
ENSG00000161547	SRSF2	100	100.000	ENSEASG00005004319	-	100	100.000	Equus_asinus_asinus
ENSG00000161547	SRSF2	100	100.000	ENSECAG00000033515	-	100	100.000	Equus_caballus
ENSG00000161547	SRSF2	100	100.000	ENSFCAG00000043466	-	100	100.000	Felis_catus
ENSG00000161547	SRSF2	99	94.954	ENSFALG00000000869	-	99	94.009	Ficedula_albicollis
ENSG00000161547	SRSF2	100	86.603	ENSFDAG00000012646	-	100	86.603	Fukomys_damarensis
ENSG00000161547	SRSF2	77	96.000	ENSGMOG00000001599	srsf2a	51	96.000	Gadus_morhua
ENSG00000161547	SRSF2	77	98.000	ENSGMOG00000007642	srsf2b	62	72.000	Gadus_morhua
ENSG00000161547	SRSF2	100	98.190	ENSGALG00000017357	SRSF2	100	98.190	Gallus_gallus
ENSG00000161547	SRSF2	82	94.393	ENSGAFG00000005791	srsf2a	50	95.000	Gambusia_affinis
ENSG00000161547	SRSF2	77	96.000	ENSGACG00000014884	srsf2b	61	66.452	Gasterosteus_aculeatus
ENSG00000161547	SRSF2	100	100.000	ENSGAGG00000024457	-	100	100.000	Gopherus_agassizii
ENSG00000161547	SRSF2	100	98.086	ENSGGOG00000014378	SRSF2	100	98.086	Gorilla_gorilla
ENSG00000161547	SRSF2	72	82.979	ENSGGOG00000022679	SRSF8	51	62.069	Gorilla_gorilla
ENSG00000161547	SRSF2	77	95.000	ENSHBUG00000014017	srsf2b	62	75.373	Haplochromis_burtoni
ENSG00000161547	SRSF2	85	94.690	ENSHBUG00000013254	srsf2a	61	78.102	Haplochromis_burtoni
ENSG00000161547	SRSF2	100	100.000	ENSHGLG00000017262	-	100	100.000	Heterocephalus_glaber_female
ENSG00000161547	SRSF2	67	91.954	ENSHCOG00000008598	-	69	90.909	Hippocampus_comes
ENSG00000161547	SRSF2	72	100.000	ENSSTOG00000025265	-	100	87.081	Ictidomys_tridecemlineatus
ENSG00000161547	SRSF2	100	100.000	ENSJJAG00000013794	Srsf2	100	100.000	Jaculus_jaculus
ENSG00000161547	SRSF2	76	94.949	ENSLBEG00000022770	srsf2b	55	77.273	Labrus_bergylta
ENSG00000161547	SRSF2	84	95.536	ENSLACG00000013394	srsf2a	51	95.536	Latimeria_chalumnae
ENSG00000161547	SRSF2	100	100.000	ENSMFAG00000045524	SRSF2	100	100.000	Macaca_fascicularis
ENSG00000161547	SRSF2	72	82.979	ENSMFAG00000028658	SRSF8	51	62.069	Macaca_fascicularis
ENSG00000161547	SRSF2	100	100.000	ENSMMUG00000022413	SRSF2	100	100.000	Macaca_mulatta
ENSG00000161547	SRSF2	72	82.979	ENSMMUG00000007639	SRSF8	51	62.069	Macaca_mulatta
ENSG00000161547	SRSF2	100	100.000	ENSMNEG00000031444	SRSF2	100	100.000	Macaca_nemestrina
ENSG00000161547	SRSF2	72	82.979	ENSMNEG00000027570	SRSF8	50	62.585	Macaca_nemestrina
ENSG00000161547	SRSF2	100	89.952	ENSMLEG00000025525	SRSF2	100	89.952	Mandrillus_leucophaeus
ENSG00000161547	SRSF2	82	94.393	ENSMAMG00000002803	srsf2a	58	77.612	Mastacembelus_armatus
ENSG00000161547	SRSF2	85	94.690	ENSMZEG00005004205	srsf2a	61	78.102	Maylandia_zebra
ENSG00000161547	SRSF2	100	100.000	ENSMAUG00000022242	Srsf2	100	100.000	Mesocricetus_auratus
ENSG00000161547	SRSF2	100	100.000	ENSMICG00000016956	-	100	100.000	Microcebus_murinus
ENSG00000161547	SRSF2	77	95.000	ENSMMOG00000020132	srsf2b	67	78.571	Mola_mola
ENSG00000161547	SRSF2	99	98.630	ENSMODG00000001575	-	86	98.630	Monodelphis_domestica
ENSG00000161547	SRSF2	75	95.876	ENSMALG00000014936	srsf2b	62	74.074	Monopterus_albus
ENSG00000161547	SRSF2	100	100.000	MGP_CAROLIEiJ_G0017457	Srsf2	100	100.000	Mus_caroli
ENSG00000161547	SRSF2	100	100.000	ENSMUSG00000034120	Srsf2	100	100.000	Mus_musculus
ENSG00000161547	SRSF2	100	100.000	MGP_PahariEiJ_G0018587	Srsf2	100	100.000	Mus_pahari
ENSG00000161547	SRSF2	100	100.000	MGP_SPRETEiJ_G0018303	Srsf2	100	100.000	Mus_spretus
ENSG00000161547	SRSF2	100	93.893	ENSMPUG00000013408	-	84	84.932	Mustela_putorius_furo
ENSG00000161547	SRSF2	100	100.000	ENSNGAG00000021718	Srsf2	100	100.000	Nannospalax_galili
ENSG00000161547	SRSF2	100	97.059	ENSNLEG00000002547	SRSF2	63	97.059	Nomascus_leucogenys
ENSG00000161547	SRSF2	100	100.000	ENSMEUG00000016745	-	100	100.000	Notamacropus_eugenii
ENSG00000161547	SRSF2	100	100.000	ENSODEG00000014748	-	100	100.000	Octodon_degus
ENSG00000161547	SRSF2	77	95.000	ENSONIG00000009428	srsf2b	61	75.373	Oreochromis_niloticus
ENSG00000161547	SRSF2	82	95.327	ENSONIG00000019976	srsf2a	59	78.195	Oreochromis_niloticus
ENSG00000161547	SRSF2	90	100.000	ENSOANG00000002695	-	100	100.000	Ornithorhynchus_anatinus
ENSG00000161547	SRSF2	75	92.784	ENSORLG00000001230	srsf2b	68	74.126	Oryzias_latipes
ENSG00000161547	SRSF2	75	92.784	ENSORLG00020014420	srsf2b	68	74.126	Oryzias_latipes_hni
ENSG00000161547	SRSF2	75	92.784	ENSORLG00015007643	srsf2b	68	74.126	Oryzias_latipes_hsok
ENSG00000161547	SRSF2	75	91.753	ENSOMEG00000016488	srsf2b	63	72.593	Oryzias_melastigma
ENSG00000161547	SRSF2	100	100.000	ENSOGAG00000028335	-	100	100.000	Otolemur_garnettii
ENSG00000161547	SRSF2	92	56.557	ENSOGAG00000031672	-	63	52.174	Otolemur_garnettii
ENSG00000161547	SRSF2	99	65.441	ENSOARG00000018667	-	50	73.000	Ovis_aries
ENSG00000161547	SRSF2	99	65.441	ENSOARG00000018359	-	50	73.000	Ovis_aries
ENSG00000161547	SRSF2	100	100.000	ENSPPAG00000031433	SRSF2	100	100.000	Pan_paniscus
ENSG00000161547	SRSF2	82	78.302	ENSPTRG00000046909	SRSF8	52	58.108	Pan_troglodytes
ENSG00000161547	SRSF2	100	100.000	ENSPTRG00000009692	SRSF2	100	100.000	Pan_troglodytes
ENSG00000161547	SRSF2	100	100.000	ENSPANG00000020023	SRSF2	100	100.000	Papio_anubis
ENSG00000161547	SRSF2	72	82.979	ENSPANG00000032291	SRSF8	51	62.069	Papio_anubis
ENSG00000161547	SRSF2	77	94.000	ENSPMGG00000006860	-	60	94.000	Periophthalmus_magnuspinnatus
ENSG00000161547	SRSF2	73	76.842	ENSPMAG00000005589	srsf2b	55	68.644	Petromyzon_marinus
ENSG00000161547	SRSF2	100	100.000	ENSPCIG00000005334	-	100	100.000	Phascolarctos_cinereus
ENSG00000161547	SRSF2	82	94.393	ENSPFOG00000020356	srsf2a	56	77.612	Poecilia_formosa
ENSG00000161547	SRSF2	82	94.393	ENSPLAG00000001856	srsf2a	57	77.612	Poecilia_latipinna
ENSG00000161547	SRSF2	82	94.393	ENSPMEG00000008714	srsf2a	56	77.612	Poecilia_mexicana
ENSG00000161547	SRSF2	86	93.860	ENSPREG00000003658	srsf2a	57	77.612	Poecilia_reticulata
ENSG00000161547	SRSF2	100	100.000	ENSPPYG00000008668	SRSF2	100	100.000	Pongo_abelii
ENSG00000161547	SRSF2	100	100.000	ENSPCOG00000023806	-	100	100.000	Propithecus_coquereli
ENSG00000161547	SRSF2	90	100.000	ENSPVAG00000014264	-	100	100.000	Pteropus_vampyrus
ENSG00000161547	SRSF2	85	94.690	ENSPNYG00000001148	srsf2a	61	78.102	Pundamilia_nyererei
ENSG00000161547	SRSF2	77	95.000	ENSPNYG00000013014	srsf2b	62	75.373	Pundamilia_nyererei
ENSG00000161547	SRSF2	100	100.000	ENSRNOG00000000248	Srsf2	100	100.000	Rattus_norvegicus
ENSG00000161547	SRSF2	100	100.000	ENSRBIG00000034493	SRSF2	100	100.000	Rhinopithecus_bieti
ENSG00000161547	SRSF2	72	82.979	ENSRROG00000026503	SRSF8	51	62.069	Rhinopithecus_roxellana
ENSG00000161547	SRSF2	72	84.043	ENSRROG00000043277	-	56	61.702	Rhinopithecus_roxellana
ENSG00000161547	SRSF2	100	100.000	ENSRROG00000042457	SRSF2	100	100.000	Rhinopithecus_roxellana
ENSG00000161547	SRSF2	100	93.780	ENSSBOG00000030904	SRSF2	100	93.780	Saimiri_boliviensis_boliviensis
ENSG00000161547	SRSF2	60	83.333	ENSSBOG00000029664	SRSF8	53	63.415	Saimiri_boliviensis_boliviensis
ENSG00000161547	SRSF2	100	99.550	ENSSHAG00000005932	-	100	99.550	Sarcophilus_harrisii
ENSG00000161547	SRSF2	75	95.876	ENSSMAG00000014723	srsf2b	62	76.259	Scophthalmus_maximus
ENSG00000161547	SRSF2	77	96.000	ENSSDUG00000014762	srsf2b	62	77.273	Seriola_dumerili
ENSG00000161547	SRSF2	77	96.000	ENSSLDG00000003402	srsf2b	61	75.000	Seriola_lalandi_dorsalis
ENSG00000161547	SRSF2	100	97.619	ENSSPUG00000007582	-	100	97.619	Sphenodon_punctatus
ENSG00000161547	SRSF2	100	67.164	ENSSSCG00000012212	-	51	77.000	Sus_scrofa
ENSG00000161547	SRSF2	100	99.548	ENSSSCG00000036592	-	100	99.548	Sus_scrofa
ENSG00000161547	SRSF2	100	97.738	ENSTGUG00000007799	-	100	97.738	Taeniopygia_guttata
ENSG00000161547	SRSF2	92	85.950	ENSTRUG00000024363	srsf2b	62	79.286	Takifugu_rubripes
ENSG00000161547	SRSF2	86	92.982	ENSTNIG00000001280	srsf2a	60	77.612	Tetraodon_nigroviridis
ENSG00000161547	SRSF2	100	100.000	ENSTBEG00000014339	-	100	100.000	Tupaia_belangeri
ENSG00000161547	SRSF2	100	100.000	ENSUAMG00000013403	-	100	100.000	Ursus_americanus
ENSG00000161547	SRSF2	82	94.393	ENSXMAG00000015676	srsf2a	57	77.612	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003714	transcription corepressor activity	15652350.	NAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	9237760.9447963.15652350.18559666.21157427.21296756.21504830.22365833.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15652350.15988025.17494991.19734146.21653549.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006397	mRNA processing	8530103.	TAS	Process
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008380	RNA splicing	8530103.	TAS	Process
GO:0016605	PML body	15652350.	IDA	Component
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	12799190.15798186.21984414.23562910.	IDA	Component
GO:0016607	nuclear speck	28377597.	TAS	Component
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.