EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30463107Study of tumor-specific expression of some evolutionary new genes.Vopr Onkol2016Krukovskaya LL-
17626247Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia.Prostate2007 Sep 1Stewart GD-
20837461Expression and clinicopathologic significance of proteolysis-inducing factor in non-small-cell lung cancer: an immunohistochemical analysis.Clin Lung Cancer2010 Sep 1Wang Qdoi: 10.3816/CLC.2010.n.044.
30226544Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer.Oncol Rep2018 NovZhang Jdoi: 10.3892/or.2018.6673

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr12546483335'UTRnovel0.35
BRCAchr12546446973'UTRnovel0.1
BRCAchr1254645654Missense_MutationNAL51I0.29
CESCchr1254644939Intronnovel0.08
COADchr1254645183Silentrs752653066S93S0.52
COADchr1254648294Missense_MutationnovelM4V0.32
COADchr1254644904Intronnovel0.39
COADchr1254645226Frame_Shift_Delrs758489970G79Dfs*50.43
DLBCchr12546446483'UTRnovel0.08
ESCAchr12546483495'UTRnovel0.38
HNSCchr1254645256Missense_MutationnovelG69D0.38
HNSCchr1254645257Missense_MutationnovelG69S0.38
HNSCchr12546483245'UTRrs7470999400.36
LIHCchr1254647121Missense_MutationNAP33T0.16
LIHCchr1254644948Intronnovel0.4
LIHCchr1254644743Silentrs373661792D101D0.43
LIHCchr1254647145Missense_MutationNAA25S0.33
LUADchr1254645232Missense_MutationnovelV77A0.12
LUADchr1254645656Missense_MutationNAG50E0.62
LUADchr1254647151Missense_MutationnovelE23Q0.59
LUSCchr12546483175'UTRnovel0.43
LUSCchr12546446953'UTRnovel0.41
LUSCchr1254648247Splice_RegionNAA19A0.09
LUSCchr1254644755Splice_RegionnovelG97G0.4
LUSCchr12546483655'UTRnovel0.23
OVchr12546483605'UTRnovel0.39
READchr1254644928Intronnovel0.23
READchr1254644928Intronnovel0.2
SKCMchr1254645629Missense_MutationNAR59M0.19
SKCMchr1254644713Silentnovel*111*0.15
SKCMchr1254645227Missense_MutationNAG79R0.27
SKCMchr1254645629Missense_MutationnovelR59K0.15
SKCMchr12546446903'UTRnovel0.29
SKCMchr1254645678Missense_MutationNAE43K0.32
SKCMchr1254644731SilentNAV105V0.54
SKCMchr1254645678Missense_MutationNAE43K0.27
SKCMchr1254648280SilentNAF8F0.23
SKCMchr1254644718SilentNAL110L0.33
SKCMchr1254645678Missense_MutationNAE43K0.3
SKCMchr1254645699Missense_MutationNAE36K0.11
SKCMchr12546446903'UTRnovel0.17
SKCMchr1254645678Missense_MutationNAE43K0.48
STADchr12546483495'UTRnovel0.16
STADchr12546483675'UTRNA0.12
STADchr1254645226Frame_Shift_Delrs758489970G79Dfs*50.39
STADchr1254645248Missense_Mutationrs374154248G72R0.18
STADchr1254645226Frame_Shift_Delrs758489970G79Dfs*50.19
STADchr1254645182Missense_Mutationrs755072961V94M0.23
STADchr1254648284Missense_Mutationrs764041088L7P0.27
UCECchr12546483145'UTRnovel0.53
UCECchr1254645197Missense_Mutationrs190416576E89K0.48
UCECchr1254647147Missense_MutationNAA24V0.4
UCECchr12546483485'UTRnovel0.33
UCECchr1254645680Missense_MutationnovelK42T0.25
UCECchr12546447123'UTRnovel0.31
UCECchr1254645221Missense_Mutationrs371634807G81R0.12

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.20830.085003
PCPGAMP0.08020.028953
READDEL0.07270.064633

Survival Analysis
CancerP-value Q-value

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000161634 (Gene tree)
Gene ID
117159
Gene Symbol
DCD
Alias
AIDD|PIF|DSEP|HCAP|DCD-1
Full Name
dermcidin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
3,903 bases
Position
chr12:54,644,591-54,648,493
Accession
14669
RBP type
non-canonical RBP
Summary
This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19364862Dermcidin-derived peptides show a different mode of action than the cathelicidin LL-37 against Staphylococcus aureus.Antimicrob Agents Chemother2009 JunSenyurek Idoi: 10.1128/AAC.01679-08
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000546807DCD-203773-ENSP0000045041577 (aa)-P81605
ENST00000293371DCD-201645-ENSP00000293371110 (aa)-P81605
ENST00000456047DCD-202670-ENSP00000406773121 (aa)-P81605
Gene Model
Click here to download ENSG00000161634's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000161634Osteoporosis5.57768528811278E-517903296
ENSG00000161634Calcium1.9790000E-005-
ENSG00000161634Calcium9.8410000E-006-
ENSG00000161634Platelet Function Tests6.4900000E-007-
ENSG00000161634Platelet Function Tests6.4900000E-007-
ENSG00000161634Diabetes Mellitus, Type 22E-718372903
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161634's network
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding25416956.IPIFunction
GO:0005576extracellular region21873635.IBAComponent
GO:0005576extracellular region9736629.IDAComponent
GO:0005576extracellular region-TASComponent
GO:0006508proteolysis-IEAProcess
GO:0008233peptidase activity-IEAFunction
GO:0019730antimicrobial humoral response-TASProcess
GO:0031640killing of cells of other organism-IEAProcess
GO:0042742defense response to bacterium-IEAProcess
GO:0050832defense response to fungus-IEAProcess
GO:0070062extracellular exosome19056867.HDAComponent
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