EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30463107	Study of tumor-specific expression of some evolutionary new genes.	Vopr Onkol	2016	Krukovskaya LL	-
17626247	Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia.	Prostate	2007 Sep 1	Stewart GD	-
20837461	Expression and clinicopathologic significance of proteolysis-inducing factor in non-small-cell lung cancer: an immunohistochemical analysis.	Clin Lung Cancer	2010 Sep 1	Wang Q	doi: 10.3816/CLC.2010.n.044.
30226544	Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer.	Oncol Rep	2018 Nov	Zhang J	doi: 10.3892/or.2018.6673

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	54648333	5'UTR	novel		0.35
BRCA	chr12	54644697	3'UTR	novel		0.1
BRCA	chr12	54645654	Missense_Mutation	NA	L51I	0.29
CESC	chr12	54644939	Intron	novel		0.08
COAD	chr12	54645183	Silent	rs752653066	S93S	0.52
COAD	chr12	54648294	Missense_Mutation	novel	M4V	0.32
COAD	chr12	54644904	Intron	novel		0.39
COAD	chr12	54645226	Frame_Shift_Del	rs758489970	*G79Dfs5**	0.43
DLBC	chr12	54644648	3'UTR	novel		0.08
ESCA	chr12	54648349	5'UTR	novel		0.38
HNSC	chr12	54645256	Missense_Mutation	novel	G69D	0.38
HNSC	chr12	54645257	Missense_Mutation	novel	G69S	0.38
HNSC	chr12	54648324	5'UTR	rs747099940		0.36
LIHC	chr12	54647121	Missense_Mutation	NA	P33T	0.16
LIHC	chr12	54644948	Intron	novel		0.4
LIHC	chr12	54644743	Silent	rs373661792	D101D	0.43
LIHC	chr12	54647145	Missense_Mutation	NA	A25S	0.33
LUAD	chr12	54645232	Missense_Mutation	novel	V77A	0.12
LUAD	chr12	54645656	Missense_Mutation	NA	G50E	0.62
LUAD	chr12	54647151	Missense_Mutation	novel	E23Q	0.59
LUSC	chr12	54648317	5'UTR	novel		0.43
LUSC	chr12	54644695	3'UTR	novel		0.41
LUSC	chr12	54648247	Splice_Region	NA	A19A	0.09
LUSC	chr12	54644755	Splice_Region	novel	G97G	0.4
LUSC	chr12	54648365	5'UTR	novel		0.23
OV	chr12	54648360	5'UTR	novel		0.39
READ	chr12	54644928	Intron	novel		0.23
READ	chr12	54644928	Intron	novel		0.2
SKCM	chr12	54645629	Missense_Mutation	NA	R59M	0.19
SKCM	chr12	54644713	Silent	novel	*111*	0.15
SKCM	chr12	54645227	Missense_Mutation	NA	G79R	0.27
SKCM	chr12	54645629	Missense_Mutation	novel	R59K	0.15
SKCM	chr12	54644690	3'UTR	novel		0.29
SKCM	chr12	54645678	Missense_Mutation	NA	E43K	0.32
SKCM	chr12	54644731	Silent	NA	V105V	0.54
SKCM	chr12	54645678	Missense_Mutation	NA	E43K	0.27
SKCM	chr12	54648280	Silent	NA	F8F	0.23
SKCM	chr12	54644718	Silent	NA	L110L	0.33
SKCM	chr12	54645678	Missense_Mutation	NA	E43K	0.3
SKCM	chr12	54645699	Missense_Mutation	NA	E36K	0.11
SKCM	chr12	54644690	3'UTR	novel		0.17
SKCM	chr12	54645678	Missense_Mutation	NA	E43K	0.48
STAD	chr12	54648349	5'UTR	novel		0.16
STAD	chr12	54648367	5'UTR	NA		0.12
STAD	chr12	54645226	Frame_Shift_Del	rs758489970	*G79Dfs5**	0.39
STAD	chr12	54645248	Missense_Mutation	rs374154248	G72R	0.18
STAD	chr12	54645226	Frame_Shift_Del	rs758489970	*G79Dfs5**	0.19
STAD	chr12	54645182	Missense_Mutation	rs755072961	V94M	0.23
STAD	chr12	54648284	Missense_Mutation	rs764041088	L7P	0.27
UCEC	chr12	54648314	5'UTR	novel		0.53
UCEC	chr12	54645197	Missense_Mutation	rs190416576	E89K	0.48
UCEC	chr12	54647147	Missense_Mutation	NA	A24V	0.4
UCEC	chr12	54648348	5'UTR	novel		0.33
UCEC	chr12	54645680	Missense_Mutation	novel	K42T	0.25
UCEC	chr12	54644712	3'UTR	novel		0.31
UCEC	chr12	54645221	Missense_Mutation	rs371634807	G81R	0.12

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2083	0.085003
PCPG	AMP	0.0802	0.028953
READ	DEL	0.0727	0.064633

Survival Analysis

Cancer	P-value	Q-value
		Kaplan-Meier Survival Analysis

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000161634 (Gene tree)
Gene ID: 117159
Gene Symbol: DCD
Alias: AIDD|PIF|DSEP|HCAP|DCD-1
Full Name: dermcidin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 3,903 bases
Position: chr12:54,644,591-54,648,493
Accession: 14669
RBP type: non-canonical RBP
Summary: This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19364862	Dermcidin-derived peptides show a different mode of action than the cathelicidin LL-37 against Staphylococcus aureus.	Antimicrob Agents Chemother	2009 Jun	Senyurek I	doi: 10.1128/AAC.01679-08

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000546807	DCD-203	773	-	ENSP00000450415	77 (aa)	-	P81605
ENST00000293371	DCD-201	645	-	ENSP00000293371	110 (aa)	-	P81605
ENST00000456047	DCD-202	670	-	ENSP00000406773	121 (aa)	-	P81605

Gene Model

Click here to download ENSG00000161634's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000161634	Osteoporosis	5.57768528811278E-5	17903296
ENSG00000161634	Calcium	1.9790000E-005	-
ENSG00000161634	Calcium	9.8410000E-006	-
ENSG00000161634	Platelet Function Tests	6.4900000E-007	-
ENSG00000161634	Platelet Function Tests	6.4900000E-007	-
ENSG00000161634	Diabetes Mellitus, Type 2	2E-7	18372903

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161634's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005576	extracellular region	21873635.	IBA	Component
GO:0005576	extracellular region	9736629.	IDA	Component
GO:0005576	extracellular region	-	TAS	Component
GO:0006508	proteolysis	-	IEA	Process
GO:0008233	peptidase activity	-	IEA	Function
GO:0019730	antimicrobial humoral response	-	TAS	Process
GO:0031640	killing of cells of other organism	-	IEA	Process
GO:0042742	defense response to bacterium	-	IEA	Process
GO:0050832	defense response to fungus	-	IEA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.