EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24615626Clinical significance of RacGAP1 expression at the invasive front of gastric cancer.Gastric Cancer2015 JanSaigusa Sdoi: 10.1007/s10120-014-0355-1
29095547Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.Cancer Sci2018 JanWang Cdoi: 10.1111/cas.13434
26778597Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer.Cancer Med2016 MarBornschein Jdoi: 10.1002/cam4.610
23225332Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.Genes Chromosomes Cancer2013 MarLiang Ydoi: 10.1002/gcc.22030
23096218Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: a study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial.Cancer Chemother Pharmacol2013 JanPliarchopoulou Kdoi: 10.1007/s00280-012-2002-z
26508373Opposing prognostic roles of nuclear and cytoplasmic RACGAP1 expression in colorectal cancer patients.Hum Pathol2016 JanYeh CMdoi: 10.1016/j.humpath.2015.09.002
15863513Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.J Biol Chem2005 Jul 1Yang C-
25568185RacGAP1 expression, increasing tumor malignant potential, as a predictive biomarker for lymph node metastasis and poor prognosis in colorectal cancer.Carcinogenesis2015 MarImaoka Hdoi: 10.1093/carcin/bgu327
27284123Clinicopathological Significance of the Proliferation Markers Ki67, RacGAP1, and Topoisomerase 2 Alpha in Breast Cancer.Int J Surg Pathol2016 Octahin Sdoi: 10.1177/1066896916653211
29695400Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans.Cancer Genomics Proteomics2018 May-JunWilson BD-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1250006629SilentnovelI31I0.11
BLCAchr1249990766Missense_MutationNAP581S0.26
BLCAchr12499901113'UTRnovel0.44
BLCAchr1249994463Missense_MutationnovelS364C0.06
BLCAchr1249992370Missense_MutationnovelQ485E0.21
BLCAchr1249992024Missense_Mutationrs755241888S563L0.32
BLCAchr1249997052SilentNAV344V0.21
BLCAchr1249990719SilentnovelQ596Q0.5
BLCAchr1249990749SilentnovelL586L0.24
BLCAchr1249997144Missense_MutationnovelL314V0.42
BRCAchr1249992054Missense_MutationnovelL553R0.09
BRCAchr1249994191Nonsense_Mutationrs752168418R427*0.2
BRCAchr1249990329Missense_MutationNAS613T0.37
CESCchr1250016698SilentNAL6L0.17
CESCchr1249999673Missense_Mutationrs141502776E231K0.47
CESCchr1250004278Missense_MutationNAS151Y0.46
CESCchr1249990269SilentNA*633*0.33
COADchr1250005372SilentNAI103I0.33
COADchr1249992648SilentnovelT449T0.51
COADchr1250006450Missense_MutationnovelA91D0.07
COADchr1250016690Missense_Mutationrs202081087R9Q0.31
COADchr1249994191Nonsense_Mutationrs752168418R427*0.34
COADchr1250006528Missense_MutationnovelR65Q0.06
ESCAchr1250004264Missense_MutationnovelI156V0.33
ESCAchr12499902563'UTRnovel0.26
GBMchr1249999189Silentrs371723368T277T0.39
GBMchr1250005315Missense_MutationnovelK122N0.08
GBMchr1249994159SilentNAR437R0.37
GBMchr1249992013Missense_MutationnovelT567S0.05
HNSCchr1249992360Missense_MutationnovelH488P0.16
HNSCchr1249994245Missense_MutationnovelL409V0.2
HNSCchr1249999214Missense_MutationnovelR269T0.19
HNSCchr1249992130Missense_MutationnovelV528I0.41
HNSCchr1249994300SilentnovelD390D0.1
HNSCchr1250006602SilentnovelF40F0.44
KIRCchr1250004301Nonsense_MutationnovelS144Ifs*30.08
KIRCchr1249990285Missense_MutationNAS628P0.29
KIRCchr1250005326Missense_Mutationrs758453171E119K0.08
KIRPchr1250016673Frame_Shift_DelnovelV16Cfs*430.52
LAMLchr1250005261Frame_Shift_InsnovelN140Kfs*80.1
LGGchr1250006494SilentnovelR76R0.47
LIHCchr1249994220Missense_MutationNAA417V0.39
LIHCchr1249992291Missense_Mutationrs758935582N511S0.32
LIHCchr1249994242Missense_MutationnovelS410C0.3
LUADchr1249997167Missense_MutationnovelR306Q0.24
LUADchr1249992303Missense_MutationnovelH507R0.16
LUADchr12499902293'UTRnovel0.21
LUADchr1249994471Missense_MutationnovelM361I0.37
LUADchr1249999196Missense_MutationnovelV275E0.29
LUADchr1249999221Nonsense_MutationNAE267*0.68
LUSCchr1249994278Missense_MutationNAE398Q0.43
LUSCchr1249999164SilentnovelL286L0.52
LUSCchr1249999172Missense_MutationnovelG283A0.39
LUSCchr1249992346Missense_MutationnovelV493F0.44
LUSCchr1249994191Nonsense_Mutationrs752168418R427*0.14
LUSCchr1249994233Frame_Shift_DelnovelD413Mfs*100.42
OVchr1250006582Missense_MutationnovelT47I0.29
OVchr1250006584SilentnovelR46R0.27
OVchr1250016662SilentnovelR18R0.05
PAADchr1249992256Missense_MutationnovelR523C0.19
PAADchr1250005326Missense_Mutationrs758453171E119K0.17
PRADchr1250006495Missense_Mutationrs759482511R76H0.38
READchr1249994462Frame_Shift_DelnovelS364Yfs*80.1
READchr12499901843'UTRnovel0.17
READchr12499899683'UTRnovel0.75
READchr1249994255SilentnovelT405T0.08
SKCMchr1249997180Missense_MutationnovelP302S0.45
SKCMchr1249994237Missense_MutationNAK411N0.45
SKCMchr1250006443SilentNAC93C0.05
SKCMchr1249999158Missense_MutationNAD288N0.15
SKCMchr1249990687Missense_MutationNAP607L0.37
SKCMchr1249997188Missense_MutationnovelS299F0.37
SKCMchr1249994508Missense_MutationNAG349E0.35
SKCMchr12500167165'UTRnovel0.33
STADchr1249990288Frame_Shift_InsnovelA627Cfs*180.22
STADchr1250016666Missense_Mutationrs765698830R17H0.1
STADchr1250005289Missense_MutationnovelG131D0.36
STADchr1249990303Missense_MutationNAQ622K0.22
STADchr1249992305SilentNAA506A0.29
STADchr1250016631Nonsense_MutationNAQ29*0.09
STADchr1250005359Missense_MutationNAM108V0.09
STADchr1249994229Missense_MutationNAD414G0.07
STADchr1250016631Nonsense_MutationNAQ29*0.26
STADchr1250005327Silentrs149574224S118S0.37
STADchr1249994175Missense_MutationNAP432L0.09
STADchr1249997125Missense_MutationNAR320H0.2
TGCTchr1249999699Missense_MutationnovelT222S0.09
THCAchr1249994287Nonsense_MutationnovelK394_E395insNK*KNK0.07
THCAchr1249994287Nonsense_MutationnovelK394_E395insNK*KNK0.05
UCECchr1250006442Missense_Mutationrs147422831E94K0.3
UCECchr1250006617Missense_MutationnovelK35N0.31
UCECchr1249990329Missense_MutationNAS613N0.35
UCECchr1250005366Missense_MutationNAE105D0.32
UCECchr12499902313'UTRrs3700260060.43
UCECchr1249990704Silentrs777625401T601T0.36
UCECchr1249999223Missense_MutationnovelL266P0.06
UCECchr1249999158Missense_MutationNAD288Y0.33
UCECchr1249992064Missense_MutationnovelI550L0.32
UCECchr1249999193Missense_MutationnovelG276D0.39
UCECchr1249990778Missense_MutationnovelP577S0.11
UCECchr1249992124Missense_Mutationrs372370902R530C0.33
UCECchr1249994197Missense_MutationnovelF425V0.36
UCECchr1250005295Missense_Mutationrs138198274N129S0.45
UCECchr1249999727Nonsense_MutationNAE213*0.36
UCECchr1249992265Missense_MutationNAD520Y0.25
UCECchr1249994499Missense_MutationNAA352V0.17
UCECchr1250001252Missense_Mutationrs773499634R184C0.22
UCECchr1250006600Missense_Mutationrs558989049R41H0.38
UCECchr1249992326Silentrs778497487V499V0.42
UCECchr1249990717Missense_MutationnovelR597K0.54
UCECchr1249992301Missense_MutationnovelA508T0.21
UCECchr1250002276Missense_MutationnovelT174P0.4
UCECchr1249992593Missense_MutationnovelA468T0.37
UCECchr1250016691Missense_Mutationrs751070066R9W0.32
UCECchr1249994483Missense_MutationnovelQ357H0.2
UCECchr1249990767Frame_Shift_InsnovelP581Sfs*20.07
UCECchr1249990770Frame_Shift_DelnovelT580Lfs*400.07
UCECchr1249992311Missense_MutationNAI504M0.37
UCECchr1250004288Nonsense_MutationnovelE148*0.27
UCECchr1249997096Missense_Mutationrs765257119R330C0.18
UCECchr1250002294Missense_MutationnovelD168N0.26
UCECchr1250005371Nonsense_Mutationrs770360813R104*0.14
UCECchr1250001198Missense_Mutationrs746938824R202C0.37
UCECchr1250006436Missense_MutationnovelL96M0.34
UCECchr1249999189Silentrs371723368T277T0.27
UCECchr12499901653'UTRnovel0.23
UCECchr1249992329Frame_Shift_InsnovelV499Rfs*80.06
UCECchr1250006443SilentNAC93C0.47
UCECchr1250001224Missense_MutationnovelG193D0.13
UCECchr1250016718Splice_Regionnovel0.46
UCECchr1250006633Missense_MutationnovelF30C0.4
UCECchr12499902373'UTRnovel0.2
UCECchr1250001224Missense_MutationnovelG193D0.35
UCECchr1250002262SilentnovelK178K0.17
UCECchr12499901653'UTRnovel0.29
UCECchr1249992577Nonsense_MutationnovelL473*0.25
UCECchr1249990682Splice_SitenovelX608_splice0.32
UCECchr12499900023'UTRnovel0.3
UCECchr1249999624Missense_MutationnovelR247M0.43
UCECchr1250006495Missense_Mutationrs759482511R76H0.38
UCSchr1250016703Missense_MutationnovelM5L0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.14580.085003
READDEL0.05450.064633
STADDEL0.0930.22179

Survival Analysis
CancerP-value Q-value
THYM0.0024

Kaplan-Meier Survival Analysis

KIRC0.041

Kaplan-Meier Survival Analysis

SARC0.008

Kaplan-Meier Survival Analysis

SKCM0.0005

Kaplan-Meier Survival Analysis

BRCA0.011

Kaplan-Meier Survival Analysis

KIRP0.00012

Kaplan-Meier Survival Analysis

PAAD0.00012

Kaplan-Meier Survival Analysis

PCPG0.014

Kaplan-Meier Survival Analysis

READ0.03

Kaplan-Meier Survival Analysis

KICH0.0013

Kaplan-Meier Survival Analysis

UCEC0.02

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.0081

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

UVM0.033

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000161800 (Gene tree)
Gene ID
29127
Gene Symbol
RACGAP1
Alias
MgcRacGAP
Full Name
Rac GTPase activating protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
56,214 bases
Position
chr12:49,976,923-50,033,136
Accession
9804
RBP type
non-canonical RBP
Summary
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12228243Molecular characterization of a metastatic neuroendocrine cell cancer arising in the prostates of transgenic mice.J Biol Chem2002 Nov 15Hu Y-
18481966Mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis.Biochem Soc Trans2008 JunSimon GCdoi: 10.1042/BST0360391.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000551876RACGAP1-224539-ENSP00000449186130 (aa)-F8VWX0
ENST00000548598RACGAP1-213582-ENSP0000044957449 (aa)-F8VVY0
ENST00000552004RACGAP1-225530-ENSP00000448136107 (aa)-F8VUW9
ENST00000546595RACGAP1-204634-ENSP00000449963152 (aa)-F8VV37
ENST00000427314RACGAP1-2023229-ENSP00000404190632 (aa)-Q9H0H5
ENST00000551260RACGAP1-223555-ENSP0000044886056 (aa)-F8VXH1
ENST00000552921RACGAP1-228563-ENSP00000447393150 (aa)-F8VZ66
ENST00000548824RACGAP1-215586-ENSP00000449170174 (aa)-F8VWY4
ENST00000551016RACGAP1-2212193XM_011538238ENSP00000449374632 (aa)XP_011536540Q9H0H5
ENST00000548961RACGAP1-216387-ENSP00000446889117 (aa)-F8VZ41
ENST00000548644RACGAP1-214624-ENSP00000449620177 (aa)-F8VVE5
ENST00000552310RACGAP1-227932-ENSP00000448697293 (aa)-F8VRD2
ENST00000552157RACGAP1-226386-ENSP0000044896883 (aa)-F8VYH6
ENST00000550149RACGAP1-219570-ENSP00000446642155 (aa)-F8W1E5
ENST00000550651RACGAP1-220551-ENSP00000449959111 (aa)-F8VV39
ENST00000548158RACGAP1-210596--- (aa)--
ENST00000548320RACGAP1-212554-ENSP0000044850734 (aa)-F8VRL2
ENST00000548247RACGAP1-211564-ENSP0000045007467 (aa)-F8VQF5
ENST00000549777RACGAP1-218570-ENSP00000448707129 (aa)-F8VS54
ENST00000547905RACGAP1-2092190-ENSP00000449370632 (aa)-Q9H0H5
ENST00000546723RACGAP1-205574-ENSP00000449669155 (aa)-F8VV47
ENST00000454520RACGAP1-2033080XM_017019221ENSP00000404808632 (aa)XP_016874710Q9H0H5
ENST00000546764RACGAP1-206581-ENSP00000447177139 (aa)-F8W0L1
ENST00000551145RACGAP1-222584-ENSP00000450064124 (aa)-F8VQZ5
ENST00000549342RACGAP1-217841-ENSP00000449565280 (aa)-H0YIK5
ENST00000546786RACGAP1-207568-ENSP00000447429136 (aa)-F8W1T4
ENST00000547061RACGAP1-208581--- (aa)--
ENST00000312377RACGAP1-2013073XM_006719359ENSP00000309871632 (aa)XP_006719422Q9H0H5
Gene Model
Click here to download ENSG00000161800's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000161800rs22927211249990566?Clostridium difficile infection in multiple myeloma29594489EFO_0009130|EFO_0001378
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161800's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000281mitotic cytokinesis11085985.19468302.IDAProcess
GO:0000281mitotic cytokinesis16236794.23235882.IMPProcess
GO:0000915actomyosin contractile ring assembly16129829.IMPProcess
GO:0001669acrosomal vesicle-IEAComponent
GO:0005096GTPase activator activity10979956.IDAFunction
GO:0005096GTPase activator activity15642749.IMPFunction
GO:0005515protein binding11278976.11782313.12590651.12689593.14744859.16103226.16129829.16236794.18201571.18511905.19468300.19468302.22580824.22750944.25068414.25074804.25416956.26496610.IPIFunction
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding23235882.IDAFunction
GO:0005634nucleus11085985.11782313.16103226.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule-IEAComponent
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-TASProcess
GO:0007018microtubule-based movement-TASProcess
GO:0007283spermatogenesis12590651.IEPProcess
GO:0007405neuroblast proliferation-ISSProcess
GO:0008017microtubule binding11782313.IDAFunction
GO:0008272sulfate transport11278976.IDAProcess
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TASProcess
GO:0019901protein kinase binding19468302.IPIFunction
GO:0030496midbody11782313.16103226.18511905.IDAComponent
GO:0031234extrinsic component of cytoplasmic side of plasma membrane23235882.IDAComponent
GO:0032154cleavage furrow16103226.IDAComponent
GO:0032467positive regulation of cytokinesis16103226.IDAProcess
GO:0032467positive regulation of cytokinesis11782313.15642749.IMPProcess
GO:0035556intracellular signal transduction-IEAProcess
GO:0043014alpha-tubulin binding11085985.IDAFunction
GO:0043015gamma-tubulin binding11085985.IDAFunction
GO:0043547positive regulation of GTPase activity-IEAProcess
GO:0045995regulation of embryonic development-ISSProcess
GO:0046872metal ion binding-IEAFunction
GO:0048487beta-tubulin binding11085985.IDAFunction
GO:0051056regulation of small GTPase mediated signal transduction-TASProcess
GO:0051233spindle midzone19468302.IDAComponent
GO:0051256mitotic spindle midzone assembly16103226.IDAProcess
GO:0051988regulation of attachment of spindle microtubules to kinetochore15642749.IMPProcess
GO:0070062extracellular exosome19199708.HDAComponent
GO:0072686mitotic spindle16103226.IDAComponent
GO:0072686mitotic spindle15642749.IMPComponent
GO:0090543Flemming body-IEAComponent
GO:0097149centralspindlin complex11782313.16236794.IDAComponent
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