EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24615626	Clinical significance of RacGAP1 expression at the invasive front of gastric cancer.	Gastric Cancer	2015 Jan	Saigusa S	doi: 10.1007/s10120-014-0355-1
29095547	Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.	Cancer Sci	2018 Jan	Wang C	doi: 10.1111/cas.13434
26778597	Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer.	Cancer Med	2016 Mar	Bornschein J	doi: 10.1002/cam4.610
23225332	Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.	Genes Chromosomes Cancer	2013 Mar	Liang Y	doi: 10.1002/gcc.22030
23096218	Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: a study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial.	Cancer Chemother Pharmacol	2013 Jan	Pliarchopoulou K	doi: 10.1007/s00280-012-2002-z
26508373	Opposing prognostic roles of nuclear and cytoplasmic RACGAP1 expression in colorectal cancer patients.	Hum Pathol	2016 Jan	Yeh CM	doi: 10.1016/j.humpath.2015.09.002
15863513	Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.	J Biol Chem	2005 Jul 1	Yang C	-
25568185	RacGAP1 expression, increasing tumor malignant potential, as a predictive biomarker for lymph node metastasis and poor prognosis in colorectal cancer.	Carcinogenesis	2015 Mar	Imaoka H	doi: 10.1093/carcin/bgu327
27284123	Clinicopathological Significance of the Proliferation Markers Ki67, RacGAP1, and Topoisomerase 2 Alpha in Breast Cancer.	Int J Surg Pathol	2016 Oct	ahin S	doi: 10.1177/1066896916653211
29695400	Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans.	Cancer Genomics Proteomics	2018 May-Jun	Wilson BD	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	50006629	Silent	novel	I31I	0.11
BLCA	chr12	49990766	Missense_Mutation	NA	P581S	0.26
BLCA	chr12	49990111	3'UTR	novel		0.44
BLCA	chr12	49994463	Missense_Mutation	novel	S364C	0.06
BLCA	chr12	49992370	Missense_Mutation	novel	Q485E	0.21
BLCA	chr12	49992024	Missense_Mutation	rs755241888	S563L	0.32
BLCA	chr12	49997052	Silent	NA	V344V	0.21
BLCA	chr12	49990719	Silent	novel	Q596Q	0.5
BLCA	chr12	49990749	Silent	novel	L586L	0.24
BLCA	chr12	49997144	Missense_Mutation	novel	L314V	0.42
BRCA	chr12	49992054	Missense_Mutation	novel	L553R	0.09
BRCA	chr12	49994191	Nonsense_Mutation	rs752168418	R427*	0.2
BRCA	chr12	49990329	Missense_Mutation	NA	S613T	0.37
CESC	chr12	50016698	Silent	NA	L6L	0.17
CESC	chr12	49999673	Missense_Mutation	rs141502776	E231K	0.47
CESC	chr12	50004278	Missense_Mutation	NA	S151Y	0.46
CESC	chr12	49990269	Silent	NA	*633*	0.33
COAD	chr12	50005372	Silent	NA	I103I	0.33
COAD	chr12	49992648	Silent	novel	T449T	0.51
COAD	chr12	50006450	Missense_Mutation	novel	A91D	0.07
COAD	chr12	50016690	Missense_Mutation	rs202081087	R9Q	0.31
COAD	chr12	49994191	Nonsense_Mutation	rs752168418	R427*	0.34
COAD	chr12	50006528	Missense_Mutation	novel	R65Q	0.06
ESCA	chr12	50004264	Missense_Mutation	novel	I156V	0.33
ESCA	chr12	49990256	3'UTR	novel		0.26
GBM	chr12	49999189	Silent	rs371723368	T277T	0.39
GBM	chr12	50005315	Missense_Mutation	novel	K122N	0.08
GBM	chr12	49994159	Silent	NA	R437R	0.37
GBM	chr12	49992013	Missense_Mutation	novel	T567S	0.05
HNSC	chr12	49992360	Missense_Mutation	novel	H488P	0.16
HNSC	chr12	49994245	Missense_Mutation	novel	L409V	0.2
HNSC	chr12	49999214	Missense_Mutation	novel	R269T	0.19
HNSC	chr12	49992130	Missense_Mutation	novel	V528I	0.41
HNSC	chr12	49994300	Silent	novel	D390D	0.1
HNSC	chr12	50006602	Silent	novel	F40F	0.44
KIRC	chr12	50004301	Nonsense_Mutation	novel	*S144Ifs3**	0.08
KIRC	chr12	49990285	Missense_Mutation	NA	S628P	0.29
KIRC	chr12	50005326	Missense_Mutation	rs758453171	E119K	0.08
KIRP	chr12	50016673	Frame_Shift_Del	novel	*V16Cfs43**	0.52
LAML	chr12	50005261	Frame_Shift_Ins	novel	*N140Kfs8**	0.1
LGG	chr12	50006494	Silent	novel	R76R	0.47
LIHC	chr12	49994220	Missense_Mutation	NA	A417V	0.39
LIHC	chr12	49992291	Missense_Mutation	rs758935582	N511S	0.32
LIHC	chr12	49994242	Missense_Mutation	novel	S410C	0.3
LUAD	chr12	49997167	Missense_Mutation	novel	R306Q	0.24
LUAD	chr12	49992303	Missense_Mutation	novel	H507R	0.16
LUAD	chr12	49990229	3'UTR	novel		0.21
LUAD	chr12	49994471	Missense_Mutation	novel	M361I	0.37
LUAD	chr12	49999196	Missense_Mutation	novel	V275E	0.29
LUAD	chr12	49999221	Nonsense_Mutation	NA	E267*	0.68
LUSC	chr12	49994278	Missense_Mutation	NA	E398Q	0.43
LUSC	chr12	49999164	Silent	novel	L286L	0.52
LUSC	chr12	49999172	Missense_Mutation	novel	G283A	0.39
LUSC	chr12	49992346	Missense_Mutation	novel	V493F	0.44
LUSC	chr12	49994191	Nonsense_Mutation	rs752168418	R427*	0.14
LUSC	chr12	49994233	Frame_Shift_Del	novel	*D413Mfs10**	0.42
OV	chr12	50006582	Missense_Mutation	novel	T47I	0.29
OV	chr12	50006584	Silent	novel	R46R	0.27
OV	chr12	50016662	Silent	novel	R18R	0.05
PAAD	chr12	49992256	Missense_Mutation	novel	R523C	0.19
PAAD	chr12	50005326	Missense_Mutation	rs758453171	E119K	0.17
PRAD	chr12	50006495	Missense_Mutation	rs759482511	R76H	0.38
READ	chr12	49994462	Frame_Shift_Del	novel	*S364Yfs8**	0.1
READ	chr12	49990184	3'UTR	novel		0.17
READ	chr12	49989968	3'UTR	novel		0.75
READ	chr12	49994255	Silent	novel	T405T	0.08
SKCM	chr12	49997180	Missense_Mutation	novel	P302S	0.45
SKCM	chr12	49994237	Missense_Mutation	NA	K411N	0.45
SKCM	chr12	50006443	Silent	NA	C93C	0.05
SKCM	chr12	49999158	Missense_Mutation	NA	D288N	0.15
SKCM	chr12	49990687	Missense_Mutation	NA	P607L	0.37
SKCM	chr12	49997188	Missense_Mutation	novel	S299F	0.37
SKCM	chr12	49994508	Missense_Mutation	NA	G349E	0.35
SKCM	chr12	50016716	5'UTR	novel		0.33
STAD	chr12	49990288	Frame_Shift_Ins	novel	*A627Cfs18**	0.22
STAD	chr12	50016666	Missense_Mutation	rs765698830	R17H	0.1
STAD	chr12	50005289	Missense_Mutation	novel	G131D	0.36
STAD	chr12	49990303	Missense_Mutation	NA	Q622K	0.22
STAD	chr12	49992305	Silent	NA	A506A	0.29
STAD	chr12	50016631	Nonsense_Mutation	NA	Q29*	0.09
STAD	chr12	50005359	Missense_Mutation	NA	M108V	0.09
STAD	chr12	49994229	Missense_Mutation	NA	D414G	0.07
STAD	chr12	50016631	Nonsense_Mutation	NA	Q29*	0.26
STAD	chr12	50005327	Silent	rs149574224	S118S	0.37
STAD	chr12	49994175	Missense_Mutation	NA	P432L	0.09
STAD	chr12	49997125	Missense_Mutation	NA	R320H	0.2
TGCT	chr12	49999699	Missense_Mutation	novel	T222S	0.09
THCA	chr12	49994287	Nonsense_Mutation	novel	*K394_E395insNKKNK**	0.07
THCA	chr12	49994287	Nonsense_Mutation	novel	*K394_E395insNKKNK**	0.05
UCEC	chr12	50006442	Missense_Mutation	rs147422831	E94K	0.3
UCEC	chr12	50006617	Missense_Mutation	novel	K35N	0.31
UCEC	chr12	49990329	Missense_Mutation	NA	S613N	0.35
UCEC	chr12	50005366	Missense_Mutation	NA	E105D	0.32
UCEC	chr12	49990231	3'UTR	rs370026006		0.43
UCEC	chr12	49990704	Silent	rs777625401	T601T	0.36
UCEC	chr12	49999223	Missense_Mutation	novel	L266P	0.06
UCEC	chr12	49999158	Missense_Mutation	NA	D288Y	0.33
UCEC	chr12	49992064	Missense_Mutation	novel	I550L	0.32
UCEC	chr12	49999193	Missense_Mutation	novel	G276D	0.39
UCEC	chr12	49990778	Missense_Mutation	novel	P577S	0.11
UCEC	chr12	49992124	Missense_Mutation	rs372370902	R530C	0.33
UCEC	chr12	49994197	Missense_Mutation	novel	F425V	0.36
UCEC	chr12	50005295	Missense_Mutation	rs138198274	N129S	0.45
UCEC	chr12	49999727	Nonsense_Mutation	NA	E213*	0.36
UCEC	chr12	49992265	Missense_Mutation	NA	D520Y	0.25
UCEC	chr12	49994499	Missense_Mutation	NA	A352V	0.17
UCEC	chr12	50001252	Missense_Mutation	rs773499634	R184C	0.22
UCEC	chr12	50006600	Missense_Mutation	rs558989049	R41H	0.38
UCEC	chr12	49992326	Silent	rs778497487	V499V	0.42
UCEC	chr12	49990717	Missense_Mutation	novel	R597K	0.54
UCEC	chr12	49992301	Missense_Mutation	novel	A508T	0.21
UCEC	chr12	50002276	Missense_Mutation	novel	T174P	0.4
UCEC	chr12	49992593	Missense_Mutation	novel	A468T	0.37
UCEC	chr12	50016691	Missense_Mutation	rs751070066	R9W	0.32
UCEC	chr12	49994483	Missense_Mutation	novel	Q357H	0.2
UCEC	chr12	49990767	Frame_Shift_Ins	novel	*P581Sfs2**	0.07
UCEC	chr12	49990770	Frame_Shift_Del	novel	*T580Lfs40**	0.07
UCEC	chr12	49992311	Missense_Mutation	NA	I504M	0.37
UCEC	chr12	50004288	Nonsense_Mutation	novel	E148*	0.27
UCEC	chr12	49997096	Missense_Mutation	rs765257119	R330C	0.18
UCEC	chr12	50002294	Missense_Mutation	novel	D168N	0.26
UCEC	chr12	50005371	Nonsense_Mutation	rs770360813	R104*	0.14
UCEC	chr12	50001198	Missense_Mutation	rs746938824	R202C	0.37
UCEC	chr12	50006436	Missense_Mutation	novel	L96M	0.34
UCEC	chr12	49999189	Silent	rs371723368	T277T	0.27
UCEC	chr12	49990165	3'UTR	novel		0.23
UCEC	chr12	49992329	Frame_Shift_Ins	novel	*V499Rfs8**	0.06
UCEC	chr12	50006443	Silent	NA	C93C	0.47
UCEC	chr12	50001224	Missense_Mutation	novel	G193D	0.13
UCEC	chr12	50016718	Splice_Region	novel		0.46
UCEC	chr12	50006633	Missense_Mutation	novel	F30C	0.4
UCEC	chr12	49990237	3'UTR	novel		0.2
UCEC	chr12	50001224	Missense_Mutation	novel	G193D	0.35
UCEC	chr12	50002262	Silent	novel	K178K	0.17
UCEC	chr12	49990165	3'UTR	novel		0.29
UCEC	chr12	49992577	Nonsense_Mutation	novel	L473*	0.25
UCEC	chr12	49990682	Splice_Site	novel	X608_splice	0.32
UCEC	chr12	49990002	3'UTR	novel		0.3
UCEC	chr12	49999624	Missense_Mutation	novel	R247M	0.43
UCEC	chr12	50006495	Missense_Mutation	rs759482511	R76H	0.38
UCS	chr12	50016703	Missense_Mutation	novel	M5L	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.1458	0.085003
READ	DEL	0.0545	0.064633
STAD	DEL	0.093	0.22179

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0024	Kaplan-Meier Survival Analysis
KIRC	0.041	Kaplan-Meier Survival Analysis
SARC	0.008	Kaplan-Meier Survival Analysis
SKCM	0.0005	Kaplan-Meier Survival Analysis
BRCA	0.011	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
PAAD	0.00012	Kaplan-Meier Survival Analysis
PCPG	0.014	Kaplan-Meier Survival Analysis
READ	0.03	Kaplan-Meier Survival Analysis
KICH	0.0013	Kaplan-Meier Survival Analysis
UCEC	0.02	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.0081	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000161800 (Gene tree)
Gene ID: 29127
Gene Symbol: RACGAP1
Alias: MgcRacGAP
Full Name: Rac GTPase activating protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 56,214 bases
Position: chr12:49,976,923-50,033,136
Accession: 9804
RBP type: non-canonical RBP
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12228243	Molecular characterization of a metastatic neuroendocrine cell cancer arising in the prostates of transgenic mice.	J Biol Chem	2002 Nov 15	Hu Y	-
18481966	Mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis.	Biochem Soc Trans	2008 Jun	Simon GC	doi: 10.1042/BST0360391.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000551876	RACGAP1-224	539	-	ENSP00000449186	130 (aa)	-	F8VWX0
ENST00000548598	RACGAP1-213	582	-	ENSP00000449574	49 (aa)	-	F8VVY0
ENST00000552004	RACGAP1-225	530	-	ENSP00000448136	107 (aa)	-	F8VUW9
ENST00000546595	RACGAP1-204	634	-	ENSP00000449963	152 (aa)	-	F8VV37
ENST00000427314	RACGAP1-202	3229	-	ENSP00000404190	632 (aa)	-	Q9H0H5
ENST00000551260	RACGAP1-223	555	-	ENSP00000448860	56 (aa)	-	F8VXH1
ENST00000552921	RACGAP1-228	563	-	ENSP00000447393	150 (aa)	-	F8VZ66
ENST00000548824	RACGAP1-215	586	-	ENSP00000449170	174 (aa)	-	F8VWY4
ENST00000551016	RACGAP1-221	2193	XM_011538238	ENSP00000449374	632 (aa)	XP_011536540	Q9H0H5
ENST00000548961	RACGAP1-216	387	-	ENSP00000446889	117 (aa)	-	F8VZ41
ENST00000548644	RACGAP1-214	624	-	ENSP00000449620	177 (aa)	-	F8VVE5
ENST00000552310	RACGAP1-227	932	-	ENSP00000448697	293 (aa)	-	F8VRD2
ENST00000552157	RACGAP1-226	386	-	ENSP00000448968	83 (aa)	-	F8VYH6
ENST00000550149	RACGAP1-219	570	-	ENSP00000446642	155 (aa)	-	F8W1E5
ENST00000550651	RACGAP1-220	551	-	ENSP00000449959	111 (aa)	-	F8VV39
ENST00000548158	RACGAP1-210	596	-	-	- (aa)	-	-
ENST00000548320	RACGAP1-212	554	-	ENSP00000448507	34 (aa)	-	F8VRL2
ENST00000548247	RACGAP1-211	564	-	ENSP00000450074	67 (aa)	-	F8VQF5
ENST00000549777	RACGAP1-218	570	-	ENSP00000448707	129 (aa)	-	F8VS54
ENST00000547905	RACGAP1-209	2190	-	ENSP00000449370	632 (aa)	-	Q9H0H5
ENST00000546723	RACGAP1-205	574	-	ENSP00000449669	155 (aa)	-	F8VV47
ENST00000454520	RACGAP1-203	3080	XM_017019221	ENSP00000404808	632 (aa)	XP_016874710	Q9H0H5
ENST00000546764	RACGAP1-206	581	-	ENSP00000447177	139 (aa)	-	F8W0L1
ENST00000551145	RACGAP1-222	584	-	ENSP00000450064	124 (aa)	-	F8VQZ5
ENST00000549342	RACGAP1-217	841	-	ENSP00000449565	280 (aa)	-	H0YIK5
ENST00000546786	RACGAP1-207	568	-	ENSP00000447429	136 (aa)	-	F8W1T4
ENST00000547061	RACGAP1-208	581	-	-	- (aa)	-	-
ENST00000312377	RACGAP1-201	3073	XM_006719359	ENSP00000309871	632 (aa)	XP_006719422	Q9H0H5

Gene Model

Click here to download ENSG00000161800's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000161800	rs2292721	12	49990566	?	Clostridium difficile infection in multiple myeloma	29594489			EFO_0009130\|EFO_0001378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161800's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	11085985.19468302.	IDA	Process
GO:0000281	mitotic cytokinesis	16236794.23235882.	IMP	Process
GO:0000915	actomyosin contractile ring assembly	16129829.	IMP	Process
GO:0001669	acrosomal vesicle	-	IEA	Component
GO:0005096	GTPase activator activity	10979956.	IDA	Function
GO:0005096	GTPase activator activity	15642749.	IMP	Function
GO:0005515	protein binding	11278976.11782313.12590651.12689593.14744859.16103226.16129829.16236794.18201571.18511905.19468300.19468302.22580824.22750944.25068414.25074804.25416956.26496610.	IPI	Function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	23235882.	IDA	Function
GO:0005634	nucleus	11085985.11782313.16103226.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	-	IEA	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0007018	microtubule-based movement	-	TAS	Process
GO:0007283	spermatogenesis	12590651.	IEP	Process
GO:0007405	neuroblast proliferation	-	ISS	Process
GO:0008017	microtubule binding	11782313.	IDA	Function
GO:0008272	sulfate transport	11278976.	IDA	Process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019901	protein kinase binding	19468302.	IPI	Function
GO:0030496	midbody	11782313.16103226.18511905.	IDA	Component
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	23235882.	IDA	Component
GO:0032154	cleavage furrow	16103226.	IDA	Component
GO:0032467	positive regulation of cytokinesis	16103226.	IDA	Process
GO:0032467	positive regulation of cytokinesis	11782313.15642749.	IMP	Process
GO:0035556	intracellular signal transduction	-	IEA	Process
GO:0043014	alpha-tubulin binding	11085985.	IDA	Function
GO:0043015	gamma-tubulin binding	11085985.	IDA	Function
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0045995	regulation of embryonic development	-	ISS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048487	beta-tubulin binding	11085985.	IDA	Function
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	Process
GO:0051233	spindle midzone	19468302.	IDA	Component
GO:0051256	mitotic spindle midzone assembly	16103226.	IDA	Process
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	15642749.	IMP	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:0072686	mitotic spindle	16103226.	IDA	Component
GO:0072686	mitotic spindle	15642749.	IMP	Component
GO:0090543	Flemming body	-	IEA	Component
GO:0097149	centralspindlin complex	11782313.16236794.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.