EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28466778	miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1.	Tumour Biol	2017 May	Li W	doi: 10.1177/1010428317698389.
28911096	Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases.	Nucleic Acids Res	2017 Sep 6	Li W	doi: 10.1093/nar/gkx560.
24844222	Decreased expression of EIF4A1 after preoperative brachytherapy predicts better tumor-specific survival in cervical cancer.	Int J Gynecol Cancer	2014 Jun	Liang S	doi: 10.1097/IGC.0000000000000152.
26614665	Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.	Biochem Soc Trans	2015 Dec	Raza F	doi: 10.1042/BST20150163.
26936591	MiR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1.	Oncol Rep	2016 May	Cao W	doi: 10.3892/or.2016.4643

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	7575146	Missense_Mutation	novel	S78C	0.07	ResIII
BLCA	chr17	7574841	Intron	novel		0.07
BLCA	chr17	7577388	Silent	novel	V223V	0.11
BLCA	chr17	7577673	Missense_Mutation	NA	K291N	0.18
BLCA	chr17	7574728	Intron	novel		0.47
BLCA	chr17	7577875	Missense_Mutation	novel	R319C	0.51
BLCA	chr17	7577972	Intron	novel		0.32
BLCA	chr17	7574759	Intron	novel		0.34
BLCA	chr17	7578418	Missense_Mutation	novel	R385G	0.16
BRCA	chr17	7574745	Intron	NA		0.32
BRCA	chr17	7578165	Missense_Mutation	novel	A333S	0.2
BRCA	chr17	7577482	Nonsense_Mutation	NA	R255*	0.15
BRCA	chr17	7577972	Intron	NA		0.41
BRCA	chr17	7578876	3'UTR	novel		0.35
BRCA	chr17	7577425	Missense_Mutation	novel	V236F	0.09
CESC	chr17	7577916	Splice_Region	NA	L332L	0.24
CESC	chr17	7576523	Splice_Site	NA	X116_splice	0.17
CESC	chr17	7577357	Missense_Mutation	NA	S213L	0.19
CESC	chr17	7576831	Intron	rs766373704		0.63
CESC	chr17	7577852	Missense_Mutation	novel	R311Q	0.15
CESC	chr17	7577066	Silent	novel	Y175Y	0.23
CESC	chr17	7575241	Nonsense_Mutation	novel	R110*	0.32
CESC	chr17	7576563	Missense_Mutation	novel	A129T	0.46
CESC	chr17	7578053	Intron	novel		0.56
CESC	chr17	7576656	Missense_Mutation	novel	G160S	0.54
CESC	chr17	7574647	Silent	NA	I58I	0.39
CESC	chr17	7575146	Missense_Mutation	NA	S78Y	0.39	ResIII
COAD	chr17	7578581	3'UTR	novel		0.25
COAD	chr17	7578512	3'UTR	novel		0.24
COAD	chr17	7577607	Silent	NA	T269T	0.24
COAD	chr17	7577416	Missense_Mutation	NA	R233W	0.12
ESCA	chr17	7578701	3'UTR	novel		0.71
GBM	chr17	7577606	Missense_Mutation	NA	T269N	0.19
GBM	chr17	7577345	Missense_Mutation	novel	V209E	0.04
GBM	chr17	7577459	Missense_Mutation	NA	R247H	0.25
GBM	chr17	7577851	Nonsense_Mutation	novel	R311*	0.36
GBM	chr17	7577973	Intron	novel		0.09
GBM	chr17	7578036	Intron	novel		0.06
GBM	chr17	7572863	Nonsense_Mutation	NA	R8*	0.41
HNSC	chr17	7576637	Silent	rs746334111	H153H	0.08
HNSC	chr17	7574737	Intron	novel		0.45
HNSC	chr17	7574771	Intron	novel		0.2
KIRC	chr17	7576939	Intron	NA		0.28
KIRP	chr17	7575260	Splice_Site	NA	X115_splice	0.22
KIRP	chr17	7578229	Missense_Mutation	novel	E354G	0.56
LAML	chr17	7578164	Splice_Site	novel	X333_splice	0.15
LGG	chr17	7572842	Translation_Start_Site	novel	M1?	0.12
LGG	chr17	7578368	Missense_Mutation	NA	R368H	0.1
LGG	chr17	7577482	Nonsense_Mutation	NA	R255*	0.45
LGG	chr17	7577862	Missense_Mutation	novel	I314M	0.32
LGG	chr17	7574605	Frame_Shift_Del	novel	*R45Vfs28**	0.36	ResIII
LGG	chr17	7577416	Missense_Mutation	NA	R233W	0.23
LIHC	chr17	7574275	Silent	novel	G13G	0.16
LUAD	chr17	7576649	Silent	novel	G157G	0.07
LUAD	chr17	7577677	Missense_Mutation	NA	H293D	0.08
LUAD	chr17	7577666	Missense_Mutation	novel	T289I	0.23
LUAD	chr17	7576915	Intron	novel		0.26
LUAD	chr17	7575168	In_Frame_Del	novel	F86_I88del	0.07
LUAD	chr17	7576869	Intron	novel		0.23
LUSC	chr17	7578603	3'UTR	novel		0.7
LUSC	chr17	7572861	Missense_Mutation	rs199974690	S7F	0.35
LUSC	chr17	7575141	Silent	novel	A76A	0.23
LUSC	chr17	7578024	Intron	novel		0.26
LUSC	chr17	7578577	3'UTR	novel		0.54
MESO	chr17	7577889	Missense_Mutation	novel	S323R	0.17
OV	chr17	7577639	Missense_Mutation	NA	N280S	0.81
OV	chr17	7578426	Silent	NA	I387I	0.25
OV	chr17	7574547	Frame_Shift_Ins	novel	N26*	0.06
OV	chr17	7576835	Intron	NA		0.4
OV	chr17	7578173	Silent	novel	G335G	0.13
OV	chr17	7572828	5'UTR	novel		0.15
OV	chr17	7576610	Silent	NA	V144V	0.1
PAAD	chr17	7572833	5'UTR	rs752960302		0.23
PRAD	chr17	7576944	Intron	novel		0.21
PRAD	chr17	7577598	Missense_Mutation	NA	L266F	0.87
PRAD	chr17	7578233	Silent	rs757110802	N355N	0.28
SKCM	chr17	7578489	3'UTR	novel		0.41
SKCM	chr17	7572848	Missense_Mutation	rs779627306	A3T	0.83
SKCM	chr17	7576591	Missense_Mutation	novel	T138I	0.44
SKCM	chr17	7576592	Silent	novel	T138T	0.44
SKCM	chr17	7576694	Splice_Site	NA	X172_splice	0.23
SKCM	chr17	7572851	Missense_Mutation	NA	S4C	0.29
SKCM	chr17	7575228	Silent	NA	V105V	0.25
SKCM	chr17	7577974	Intron	novel		0.3
STAD	chr17	7575248	Missense_Mutation	novel	L112W	0.32
STAD	chr17	7576694	Splice_Site	NA	X172_splice	0.36
STAD	chr17	7578656	3'UTR	novel		0.5
STAD	chr17	7578449	Missense_Mutation	NA	I395T	0.25
STAD	chr17	7572844	Translation_Start_Site	NA	M1?	0.1
THCA	chr17	7578537	3'UTR	novel		0.09
UCEC	chr17	7575219	Silent	NA	Q102Q	0.27
UCEC	chr17	7578418	Nonsense_Mutation	NA	R385*	0.3
UCEC	chr17	7578592	3'UTR	novel		0.33
UCEC	chr17	7574636	Missense_Mutation	novel	P55S	0.11	ResIII
UCEC	chr17	7574299	Silent	novel	G21G	0.46
UCEC	chr17	7577585	Missense_Mutation	novel	T262I	0.1
UCEC	chr17	7577438	Missense_Mutation	novel	E240G	0.34
UCEC	chr17	7577586	Silent	novel	T262T	0.33
UCEC	chr17	7576599	Missense_Mutation	rs756236929	R141C	0.49
UCEC	chr17	7578376	Missense_Mutation	novel	V371M	0.07
UCEC	chr17	7578165	Missense_Mutation	novel	A333T	0.32
UCEC	chr17	7576680	Missense_Mutation	novel	R168W	0.38
UCEC	chr17	7577827	Missense_Mutation	NA	H303Y	0.31
UCEC	chr17	7575202	Missense_Mutation	NA	D97N	0.39
UCEC	chr17	7576527	Nonsense_Mutation	novel	Q117*	0.42
UCEC	chr17	7574730	Intron	novel		0.58
UCEC	chr17	7576833	Intron	rs760720040		0.34
UCEC	chr17	7578806	3'UTR	novel		0.21
UCEC	chr17	7575228	Silent	NA	V105V	0.32
UCEC	chr17	7576589	Silent	rs781209123	G137G	0.19
UCEC	chr17	7577458	Missense_Mutation	novel	R247C	0.47
UCEC	chr17	7577676	Missense_Mutation	novel	M292I	0.4
UCEC	chr17	7577071	Missense_Mutation	novel	K177T	0.47
UCEC	chr17	7578637	3'UTR	novel		0.14
UCEC	chr17	7574819	Intron	novel		0.52
UCEC	chr17	7574593	Frame_Shift_Del	novel	*E41Sfs32**	0.29	ResIII
UCEC	chr17	7578432	In_Frame_Del	novel	F390del	0.36
UCEC	chr17	7576563	Missense_Mutation	novel	A129T	0.11
UCEC	chr17	7578091	Intron	novel		0.44
UCEC	chr17	7578686	3'UTR	novel		0.59
UCEC	chr17	7574556	Missense_Mutation	novel	N28T	0.4
UCEC	chr17	7577096	Silent	rs143864020	D185D	0.29
UCEC	chr17	7578859	3'UTR	novel		0.4
UCEC	chr17	7577589	Silent	rs540578884	L263L	0.37
UCEC	chr17	7577073	Missense_Mutation	novel	M178L	0.33
UCEC	chr17	7578994	3'UTR	novel		0.22
UCEC	chr17	7578611	3'UTR	novel		0.21
UCEC	chr17	7578589	3'UTR	novel		0.45
UCEC	chr17	7576583	Silent	rs550885428	I135I	0.38
UCEC	chr17	7577652	Missense_Mutation	novel	K284N	0.18
UCEC	chr17	7577440	Silent	rs778814483	L241L	0.49
UCEC	chr17	7578589	3'UTR	novel		0.4
UCEC	chr17	7574661	Missense_Mutation	novel	I63T	0.36	ResIII

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.25	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.5784	3.9592e-10
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.00028	Kaplan-Meier Survival Analysis
ACC	0.00029	Kaplan-Meier Survival Analysis
UCS	0.046	Kaplan-Meier Survival Analysis
HNSC	0.0043	Kaplan-Meier Survival Analysis
PRAD	0.042	Kaplan-Meier Survival Analysis
COAD	0.011	Kaplan-Meier Survival Analysis
BLCA	0.0018	Kaplan-Meier Survival Analysis
CHOL	0.043	Kaplan-Meier Survival Analysis
UVM	0.04	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000161960 (Gene tree)
Gene ID: 1973
Gene Symbol: EIF4A1
Alias: DDX2A|EIF-4A|EIF4A
Full Name: eukaryotic translation initiation factor 4A1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 6,301 bases
Position: chr17:7,572,706-7,579,006
Accession: 3282
RBP type: canonical RBP
Summary: (Eukaryotic Translation Initiation Factor 4A1) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG) and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000462904	ResIII	PF04851.15	8.7e-07	1	1
ENSP00000462753	ResIII	PF04851.15	1.6e-06	1	1
ENSP00000463486	ResIII	PF04851.15	1.6e-06	1	1
ENSP00000293831	ResIII	PF04851.15	2.4e-06	1	1
ENSP00000464550	ResIII	PF04851.15	1e-05	1	1
ENSP00000463366	ResIII	PF04851.15	1.8e-05	1	1
ENSP00000463634	ResIII	PF04851.15	2.3e-05	1	1
ENSP00000464066	ResIII	PF04851.15	2.6e-05	1	1
ENSP00000462275	ResIII	PF04851.15	3.4e-05	1	1
ENSP00000463309	ResIII	PF04851.15	0.00028	1	1
ENSP00000462904	DEAD	PF00270.29	5.4e-44	1	1
ENSP00000462753	DEAD	PF00270.29	9.4e-44	1	1
ENSP00000463486	DEAD	PF00270.29	9.7e-44	1	1
ENSP00000293831	DEAD	PF00270.29	1.3e-43	1	1
ENSP00000464550	DEAD	PF00270.29	6.6e-41	1	1
ENSP00000463366	DEAD	PF00270.29	2.7e-39	1	1
ENSP00000464066	DEAD	PF00270.29	2.5e-38	1	1
ENSP00000463634	DEAD	PF00270.29	6.7e-38	1	1
ENSP00000462275	DEAD	PF00270.29	2.2e-34	1	1
ENSP00000463309	DEAD	PF00270.29	3.7e-27	1	1
ENSP00000462719	DEAD	PF00270.29	4e-22	1	1
ENSP00000463067	DEAD	PF00270.29	4.4e-09	1	1
ENSP00000462372	DEAD	PF00270.29	3.7e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15528191	Interaction between the NH2-terminal domain of eIF4A and the central domain of eIF4G modulates RNA-stimulated ATPase activity.	J Biol Chem	2005 Jan 21	Korneeva NL	-
24450646	The diverse roles of the eIF4A family: you are the company you keep.	Biochem Soc Trans	2014 Feb	Lu WT	doi: 10.1042/BST20130161.
8413273	The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.	Mol Cell Biol	1993 Nov	Pause A	-
11022043	Mutually cooperative binding of eukaryotic translation initiation factor (eIF) 3 and eIF4A to human eIF4G-1.	J Biol Chem	2000 Dec 29	Korneeva NL	-
19114555	Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.	Mol Cell Biol	2009 Mar	Yanagiya A	doi: 10.1128/MCB.01187-08
21779451	Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions.	Genes Cancer	2010 Mar	Wedeken L	doi: 10.1177/1947601910364227.
8627691	The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding.	J Virol	1996 Mar	Gross CH	-
17584618	Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.	Chem Biol	2007 Jun	Low WK	-
8139536	The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence.	Mol Cell Biol	1994 Apr	Methot N	-
24895251	Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).	Int J Cancer	2015 Oct 15	Li-Weber M	doi: 10.1002/ijc.29013
30905816	tRNA-derived fragments and tRNA halves: The new players in cancers.	Cancer Lett	2019 Jun 28	Zhu L	doi: 10.1016/j.canlet.2019.03.012
9121476	PRH75, a new nucleus-localized member of the DEAD-box protein family from higher plants.	Mol Cell Biol	1997 Apr	Lorkovic ZJ	-
19835415	How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model.	Biochemistry	2009 Nov 17	Spirin AS	doi: 10.1021/bi901379a.
18296639	PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.	Proc Natl Acad Sci U S A	2008 Mar 4	Suzuki C	doi: 10.1073/pnas.0712235105
20463023	The eukaryotic initiation factor (eIF) 4G HEAT domain promotes translation re-initiation in yeast both dependent on and independent of eIF4A mRNA helicase.	J Biol Chem	2010 Jul 16	Watanabe R	doi: 10.1074/jbc.M110.132027
25280105	MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.	Mol Cell	2014 Oct 2	Fukao A	doi: 10.1016/j.molcel.2014.09.005.
25190455	An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.	Nucleic Acids Res	2014	Fehler O	doi: 10.1093/nar/gku800
24681950	A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation.	Oncogene	2015 Mar 12	Biyanee A	doi: 10.1038/onc.2014.83
9548260	Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.	Nature	1998 Apr 2	Craig AW	-
18977752	Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc.	J Biol Chem	2008 Dec 26	Cheng S	doi: 10.1074/jbc.M807716200
15694484	Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues.	Mol Biochem Parasitol	2005 Mar	Dhalia R	-
19751846	Isolation and functional characterization of eIF4F components and poly(A)-binding protein from Plasmodium falciparum.	Parasitol Int	2009 Dec	Tuteja R	doi: 10.1016/j.parint.2009.09.001
3985612	Initiation factors eIF4A and C1 from wheat germ and the formation of mRNA X ribosome complexes.	Arch Biochem Biophys	1985 Apr	Seal SN	-
1378397	Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.	EMBO J	1992 Jul	Pause A	-
18367715	Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking.	RNA	2008 May	Lindqvist L	doi: 10.1261/rna.971208
26384734	NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII.	Protein Sci	2015 Dec	Aumayr M	doi: 10.1002/pro.2807
28757063	ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.	Bioorg Med Chem Lett	2017 Sep 1	Tillotson J	doi: 10.1016/j.bmcl.2017.07.045
12581158	Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules.	Genes Cells	2003 Feb	Hashemzadeh-Bonehi L	-
10801326	Wheat germ translation initiation factor eIF4B affects eIF4A and eIFiso4F helicase activity by increasing the ATP binding affinity of eIF4A.	Biochemistry	2000 May 16	Bi X	-
19641745	Identification and bioinformatics characterization of translation initiation complex eIF4F components and poly(A)-binding protein from Plasmodium falciparum.	Commun Integr Biol	2009 May	Tuteja R	-
18606994	Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions.	Proc Natl Acad Sci U S A	2008 Jul 15	Schutz P	doi: 10.1073/pnas.0800418105
18386287	Regulation of cap-dependent translation initiation in the early stage porcine parthenotes.	Mol Reprod Dev	2008 Dec	Susor A	doi: 10.1002/mrd.20913.
21285413	Quantitative profiling of in vivo-assembled RNA-protein complexes using a novel integrated proteomic approach.	Mol Cell Proteomics	2011 Apr	Tsai BP	doi: 10.1074/mcp.M110.007385
27313212	Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP.	Proc Natl Acad Sci U S A	2016 Jul 5	Ruoff R	doi: 10.1073/pnas.1605451113
3372532	Evidence that the requirements for ATP and wheat germ initiation factors 4A and 4F are affected by a region of satellite tobacco necrosis virus RNA that is 3' to the ribosomal binding site.	J Biol Chem	1988 Jun 15	Browning KS	-
1502180	ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae.	Proc Natl Acad Sci U S A	1992 Aug 15	Blum S	-
10409745	Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally.	Mol Cell Biol	1999 Aug	Neff CL	-
8182051	Two structural domains of initiation factor eIF-4B are involved in binding to RNA.	J Biol Chem	1994 May 20	Naranda T	-
7742374	Highly conserved genes coding for eukaryotic translation initiation factor eIF-4A of tobacco have specific alterations in functional motifs.	Biochim Biophys Acta	1995 Apr 26	Brander KA	-
11060291	Characterization of the two eIF4A-binding sites on human eIF4G-1.	J Biol Chem	2001 Jan 26	Korneeva NL	-
10913184	Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation.	Mol Cell Biol	2000 Aug	Lomakin IB	-
10872469	eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.	Annu Rev Biochem	1999	Gingras AC	-
10748132	Wheat germ poly(A)-binding protein increases the ATPase and the RNA helicase activity of translation initiation factors eIF4A, eIF4B, and eIF-iso4F.	J Biol Chem	2000 Jun 9	Bi X	-
16287867	Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation.	Mol Cell Biol	2005 Dec	Svitkin YV	-
16166382	Structural basis for the enhancement of eIF4A helicase activity by eIF4G.	Genes Dev	2005 Sep 15	Oberer M	-
15715967	Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia.	Gene	2005 Feb 28	Simmons HM	-
19204291	Crystal structure of the eIF4A-PDCD4 complex.	Proc Natl Acad Sci U S A	2009 Mar 3	Chang JH	doi: 10.1073/pnas.0808275106
18250159	Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.	Mol Cell Biol	2008 Apr	Walsh D	doi: 10.1128/MCB.01631-07
17913647	In vitro reconstitution and biochemical characterization of translation initiation by internal ribosomal entry.	Methods Enzymol	2007	Kolupaeva VG	-
17130132	Functional analysis of individual binding activities of the scaffold protein eIF4G.	J Biol Chem	2007 Jan 19	Hinton TM	-
23325513	Backbone resonance assignment of the HEAT1-domain of the human eukaryotic translation initiation factor 4GI.	Biomol NMR Assign	2014 Apr	Akabayov SR	doi: 10.1007/s12104-013-9459-5
21118117	Manipulation of the host translation initiation complex eIF4F by DNA viruses.	Biochem Soc Trans	2010 Dec	Walsh D	doi: 10.1042/BST0381511.
20948310	eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways.	Cell Cycle	2010 Oct 15	Shahbazian D	-
25255371	Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex.	Biochemistry	2014 Oct 21	Akabayov SR	doi: 10.1021/bi500600m
25079330	eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.	Nature	2014 Sep 4	Boussemart L	doi: 10.1038/nature13572
24929364	(1)H, (13)C, and (15)N backbone and sidechain chemical shift assignments for the HEAT2 domain of human eIF4GI.	Biomol NMR Assign	2015 Apr	Edmonds KA	doi: 10.1007/s12104-014-9564-0
24248602	Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.	Mol Cell Biol	2014 Feb	Dobrikov MI	doi: 10.1128/MCB.01046-13
24183571	Dynamic recognition of the mRNA cap by Saccharomyces cerevisiae eIF4E.	Structure	2013 Dec 3	O'Leary SE	doi: 10.1016/j.str.2013.09.016
24041411	The unique evolution of the programmed cell death 4 protein in plants.	BMC Evol Biol	2013 Sep 16	Cheng S	doi: 10.1186/1471-2148-13-199.
23614532	Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.	ACS Chem Biol	2013 Jul 19	Sadlish H	doi: 10.1021/cb400158t
27533468	Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.	Cell Cycle	2016 Sep 16	Malka-Mahieu H	doi: 10.1080/15384101.2016.1208862
26779409	The role of the poly(A) binding protein in the assembly of the Cap-binding complex during translation initiation in plants.	Translation (Austin)	2014 Oct 30	Gallie DR	doi: 10.4161/2169074X.2014.959378
27239032	CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A.	Cell Rep	2016 Jun 14	Chu J	doi: 10.1016/j.celrep.2016.05.005

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000580886	EIF4A1-215	562	-	-	- (aa)	-	-
ENST00000582050	EIF4A1-222	576	-	ENSP00000463380	68 (aa)	-	J3QL52
ENST00000578324	EIF4A1-207	1577	-	-	- (aa)	-	-
ENST00000581808	EIF4A1-220	205	-	-	- (aa)	-	-
ENST00000396527	EIF4A1-202	1169	-	-	- (aa)	-	-
ENST00000581841	EIF4A1-221	621	-	-	- (aa)	-	-
ENST00000580888	EIF4A1-216	710	-	ENSP00000462581	50 (aa)	-	J3KSP3
ENST00000583802	EIF4A1-229	563	-	ENSP00000463634	163 (aa)	-	J3QLN6
ENST00000584712	EIF4A1-232	782	-	-	- (aa)	-	-
ENST00000577929	EIF4A1-206	696	-	ENSP00000462372	85 (aa)	-	J3KS93
ENST00000583899	EIF4A1-230	665	-	-	- (aa)	-	-
ENST00000582848	EIF4A1-226	591	-	-	- (aa)	-	-
ENST00000578476	EIF4A1-208	573	-	ENSP00000464082	74 (aa)	-	J3QRP5
ENST00000579139	EIF4A1-213	568	-	ENSP00000461921	85 (aa)	-	J3KRC2
ENST00000293831	EIF4A1-201	1756	-	ENSP00000293831	406 (aa)	-	P60842
ENST00000585024	EIF4A1-237	577	-	ENSP00000462275	187 (aa)	-	J3KS25
ENST00000583217	EIF4A1-227	599	-	-	- (aa)	-	-
ENST00000584054	EIF4A1-231	716	-	-	- (aa)	-	-
ENST00000578495	EIF4A1-209	916	-	ENSP00000464550	300 (aa)	-	J3QS69
ENST00000582169	EIF4A1-223	552	-	ENSP00000463309	134 (aa)	-	J3QKZ9
ENST00000584798	EIF4A1-234	1440	-	-	- (aa)	-	-
ENST00000581544	EIF4A1-218	1444	-	ENSP00000463821	95 (aa)	-	J3QQP0
ENST00000577269	EIF4A1-203	1319	-	ENSP00000463486	347 (aa)	-	P60842
ENST00000582213	EIF4A1-224	560	-	-	- (aa)	-	-
ENST00000578569	EIF4A1-210	583	-	-	- (aa)	-	-
ENST00000583389	EIF4A1-228	951	-	ENSP00000462719	230 (aa)	-	J3KSZ0
ENST00000577738	EIF4A1-205	531	-	-	- (aa)	-	-
ENST00000584860	EIF4A1-235	1109	-	ENSP00000462904	257 (aa)	-	J3KTB5
ENST00000580461	EIF4A1-214	909	-	ENSP00000464320	74 (aa)	-	J3QRP5
ENST00000584901	EIF4A1-236	1021	-	-	- (aa)	-	-
ENST00000581770	EIF4A1-219	447	-	ENSP00000462741	85 (aa)	-	J3KT04
ENST00000584784	EIF4A1-233	818	-	ENSP00000463366	271 (aa)	-	J3QL43
ENST00000577731	EIF4A1-204	574	-	-	- (aa)	-	-
ENST00000582746	EIF4A1-225	1645	-	ENSP00000462753	341 (aa)	-	J3KT12
ENST00000579085	EIF4A1-212	569	-	-	- (aa)	-	-
ENST00000578754	EIF4A1-211	547	-	ENSP00000463067	117 (aa)	-	J3KTN0
ENST00000581384	EIF4A1-217	642	-	ENSP00000464066	214 (aa)	-	J3QR64

Gene Model

Click here to download ENSG00000161960's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000161960's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000161960	EIF4A1	97	31.298	ENSG00000278053	DDX52	60	32.312
ENSG00000161960	EIF4A1	98	40.854	ENSG00000168872	DDX19A	92	40.489
ENSG00000161960	EIF4A1	100	35.366	ENSG00000105671	DDX49	79	32.468
ENSG00000161960	EIF4A1	99	33.742	ENSG00000118197	DDX59	91	30.882
ENSG00000161960	EIF4A1	99	35.928	ENSG00000165732	DDX21	51	33.155
ENSG00000161960	EIF4A1	99	74.138	ENSG00000141543	EIF4A3	99	66.749
ENSG00000161960	EIF4A1	97	34.188	ENSG00000100201	DDX17	63	51.429
ENSG00000161960	EIF4A1	99	36.145	ENSG00000088205	DDX18	54	30.663
ENSG00000161960	EIF4A1	91	30.390	ENSG00000183258	DDX41	61	30.390
ENSG00000161960	EIF4A1	99	34.731	ENSG00000107625	DDX50	50	32.533
ENSG00000161960	EIF4A1	100	34.545	ENSG00000123064	DDX54	93	34.359
ENSG00000161960	EIF4A1	99	35.862	ENSG00000136271	DDX56	96	34.066
ENSG00000161960	EIF4A1	100	35.326	ENSG00000215301	DDX3X	78	32.976
ENSG00000161960	EIF4A1	99	34.409	ENSG00000213782	DDX47	81	31.989
ENSG00000161960	EIF4A1	99	38.272	ENSG00000110367	DDX6	76	38.710
ENSG00000161960	EIF4A1	96	36.196	ENSG00000080007	DDX43	59	34.635
ENSG00000161960	EIF4A1	99	34.104	ENSG00000111364	DDX55	95	32.796
ENSG00000161960	EIF4A1	98	42.073	ENSG00000157349	DDX19B	96	40.556
ENSG00000161960	EIF4A1	98	43.966	ENSG00000109832	DDX25	98	40.108
ENSG00000161960	EIF4A1	100	94.017	ENSG00000156976	EIF4A2	99	90.148
ENSG00000161960	EIF4A1	100	37.647	ENSG00000124228	DDX27	93	32.558
ENSG00000161960	EIF4A1	100	36.413	ENSG00000067048	DDX3Y	60	32.750
ENSG00000161960	EIF4A1	95	41.406	ENSG00000198563	DDX39B	92	37.687
ENSG00000161960	EIF4A1	98	41.221	ENSG00000123136	DDX39A	93	39.326
ENSG00000161960	EIF4A1	99	44.361	ENSG00000064703	DDX20	51	44.286
ENSG00000161960	EIF4A1	99	32.184	ENSG00000108654	DDX5	93	32.867

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000161960	EIF4A1	100	100.000	ENSAMEG00000016753	EIF4A1	100	100.000	Ailuropoda_melanoleuca
ENSG00000161960	EIF4A1	100	98.507	ENSAPLG00000005716	-	100	90.964	Anas_platyrhynchos
ENSG00000161960	EIF4A1	100	100.000	ENSACAG00000005524	EIF4A1	98	85.119	Anolis_carolinensis
ENSG00000161960	EIF4A1	100	96.269	ENSANAG00000021271	-	99	87.775	Aotus_nancymaae
ENSG00000161960	EIF4A1	100	95.706	ENSANAG00000033111	-	97	92.920	Aotus_nancymaae
ENSG00000161960	EIF4A1	98	78.448	ENSANAG00000015362	-	98	70.637	Aotus_nancymaae
ENSG00000161960	EIF4A1	100	81.034	ENSANAG00000023841	-	100	81.034	Aotus_nancymaae
ENSG00000161960	EIF4A1	100	100.000	ENSANAG00000035392	EIF4A1	100	100.000	Aotus_nancymaae
ENSG00000161960	EIF4A1	100	100.000	ENSBTAG00000000132	EIF4A1	100	100.000	Bos_taurus
ENSG00000161960	EIF4A1	98	76.522	WBGene00002083	inf-1	97	71.026	Caenorhabditis_elegans
ENSG00000161960	EIF4A1	100	99.387	ENSCJAG00000020470	-	99	97.929	Callithrix_jacchus
ENSG00000161960	EIF4A1	100	100.000	ENSCJAG00000015114	EIF4A1	100	100.000	Callithrix_jacchus
ENSG00000161960	EIF4A1	100	100.000	ENSCAFG00000016632	EIF4A1	100	99.507	Canis_familiaris
ENSG00000161960	EIF4A1	100	100.000	ENSCAFG00000004690	-	100	100.000	Canis_familiaris
ENSG00000161960	EIF4A1	100	83.529	ENSCAFG00020013062	-	88	83.041	Canis_lupus_dingo
ENSG00000161960	EIF4A1	100	100.000	ENSCAFG00020007858	EIF4A1	100	100.000	Canis_lupus_dingo
ENSG00000161960	EIF4A1	100	100.000	ENSCHIG00000022153	EIF4A1	100	100.000	Capra_hircus
ENSG00000161960	EIF4A1	100	95.294	ENSTSYG00000028202	-	99	91.045	Carlito_syrichta
ENSG00000161960	EIF4A1	100	88.235	ENSTSYG00000035965	-	100	80.938	Carlito_syrichta
ENSG00000161960	EIF4A1	100	100.000	ENSTSYG00000004557	EIF4A1	100	100.000	Carlito_syrichta
ENSG00000161960	EIF4A1	100	78.632	ENSCAPG00000000231	-	100	63.763	Cavia_aperea
ENSG00000161960	EIF4A1	100	100.000	ENSCAPG00000012540	EIF4A1	100	100.000	Cavia_aperea
ENSG00000161960	EIF4A1	100	77.778	ENSCPOG00000039987	-	96	74.684	Cavia_porcellus
ENSG00000161960	EIF4A1	100	100.000	ENSCPOG00000004900	-	100	99.750	Cavia_porcellus
ENSG00000161960	EIF4A1	98	83.133	ENSCCAG00000030287	-	100	76.176	Cebus_capucinus
ENSG00000161960	EIF4A1	100	100.000	ENSCCAG00000029117	-	100	95.312	Cebus_capucinus
ENSG00000161960	EIF4A1	100	97.647	ENSCCAG00000035301	-	94	93.296	Cebus_capucinus
ENSG00000161960	EIF4A1	98	84.348	ENSCATG00000034470	-	100	68.182	Cercocebus_atys
ENSG00000161960	EIF4A1	100	100.000	ENSCATG00000041861	EIF4A1	100	100.000	Cercocebus_atys
ENSG00000161960	EIF4A1	100	100.000	ENSCLAG00000006786	-	100	82.512	Chinchilla_lanigera
ENSG00000161960	EIF4A1	100	100.000	ENSCSAG00000011468	EIF4A1	100	100.000	Chlorocebus_sabaeus
ENSG00000161960	EIF4A1	100	100.000	ENSCPBG00000004702	EIF4A1	90	96.707	Chrysemys_picta_bellii
ENSG00000161960	EIF4A1	99	81.034	ENSCING00000010780	-	92	79.747	Ciona_intestinalis
ENSG00000161960	EIF4A1	99	81.034	ENSCSAVG00000000630	-	99	81.649	Ciona_savignyi
ENSG00000161960	EIF4A1	100	100.000	ENSCANG00000014450	EIF4A1	100	100.000	Colobus_angolensis_palliatus
ENSG00000161960	EIF4A1	100	97.647	ENSCANG00000043402	-	94	97.727	Colobus_angolensis_palliatus
ENSG00000161960	EIF4A1	99	64.815	ENSCANG00000040974	-	94	69.159	Colobus_angolensis_palliatus
ENSG00000161960	EIF4A1	100	88.889	ENSCANG00000037365	-	100	81.327	Colobus_angolensis_palliatus
ENSG00000161960	EIF4A1	100	99.387	ENSCANG00000038078	-	94	98.636	Colobus_angolensis_palliatus
ENSG00000161960	EIF4A1	100	100.000	ENSCGRG00001009326	Eif4a1	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000161960	EIF4A1	100	96.269	ENSCGRG00001024111	-	100	87.192	Cricetulus_griseus_chok1gshd
ENSG00000161960	EIF4A1	100	96.269	ENSCGRG00000017848	-	100	87.192	Cricetulus_griseus_crigri
ENSG00000161960	EIF4A1	100	93.252	ENSCGRG00000003437	-	96	86.280	Cricetulus_griseus_crigri
ENSG00000161960	EIF4A1	100	100.000	ENSCGRG00000007204	Eif4a1	100	100.000	Cricetulus_griseus_crigri
ENSG00000161960	EIF4A1	100	100.000	ENSDNOG00000044619	EIF4A1	100	99.507	Dasypus_novemcinctus
ENSG00000161960	EIF4A1	100	70.428	ENSDNOG00000049461	-	100	69.095	Dasypus_novemcinctus
ENSG00000161960	EIF4A1	100	100.000	ENSDORG00000014225	Eif4a1	100	100.000	Dipodomys_ordii
ENSG00000161960	EIF4A1	98	77.108	FBgn0001942	eIF4A	98	73.924	Drosophila_melanogaster
ENSG00000161960	EIF4A1	99	93.011	ENSETEG00000006701	-	100	88.177	Echinops_telfairi
ENSG00000161960	EIF4A1	100	100.000	ENSEASG00005019235	-	100	99.487	Equus_asinus_asinus
ENSG00000161960	EIF4A1	100	100.000	ENSECAG00000021478	EIF4A1	98	100.000	Equus_caballus
ENSG00000161960	EIF4A1	100	100.000	ENSEEUG00000003581	EIF4A1	100	100.000	Erinaceus_europaeus
ENSG00000161960	EIF4A1	100	100.000	ENSFCAG00000024897	EIF4A1	100	100.000	Felis_catus
ENSG00000161960	EIF4A1	99	73.457	ENSFCAG00000029768	-	92	84.444	Felis_catus
ENSG00000161960	EIF4A1	100	100.000	ENSFDAG00000008700	-	100	100.000	Fukomys_damarensis
ENSG00000161960	EIF4A1	90	80.822	ENSFDAG00000011419	-	95	73.206	Fukomys_damarensis
ENSG00000161960	EIF4A1	100	100.000	ENSGAGG00000005277	EIF4A1	96	98.438	Gopherus_agassizii
ENSG00000161960	EIF4A1	100	91.765	ENSGGOG00000024256	-	99	86.683	Gorilla_gorilla
ENSG00000161960	EIF4A1	100	97.436	ENSGGOG00000025897	-	96	94.678	Gorilla_gorilla
ENSG00000161960	EIF4A1	94	74.074	ENSGGOG00000037488	-	99	70.633	Gorilla_gorilla
ENSG00000161960	EIF4A1	100	100.000	ENSGGOG00000024702	EIF4A1	100	100.000	Gorilla_gorilla
ENSG00000161960	EIF4A1	99	76.074	ENSGGOG00000038146	-	100	68.889	Gorilla_gorilla
ENSG00000161960	EIF4A1	100	81.176	ENSHGLG00000000197	-	100	72.660	Heterocephalus_glaber_female
ENSG00000161960	EIF4A1	100	88.344	ENSHGLG00000015815	-	99	77.387	Heterocephalus_glaber_female
ENSG00000161960	EIF4A1	100	84.825	ENSHGLG00000009429	-	94	79.751	Heterocephalus_glaber_female
ENSG00000161960	EIF4A1	100	100.000	ENSHGLG00000011735	EIF4A1	100	100.000	Heterocephalus_glaber_female
ENSG00000161960	EIF4A1	100	84.825	ENSHGLG00100002547	-	94	79.751	Heterocephalus_glaber_male
ENSG00000161960	EIF4A1	100	100.000	ENSHGLG00100013114	EIF4A1	100	100.000	Heterocephalus_glaber_male
ENSG00000161960	EIF4A1	100	89.571	ENSHGLG00100000690	-	99	84.579	Heterocephalus_glaber_male
ENSG00000161960	EIF4A1	100	100.000	ENSSTOG00000024814	EIF4A1	100	100.000	Ictidomys_tridecemlineatus
ENSG00000161960	EIF4A1	100	94.872	ENSJJAG00000022263	-	94	92.513	Jaculus_jaculus
ENSG00000161960	EIF4A1	97	94.304	ENSJJAG00000008682	-	95	85.678	Jaculus_jaculus
ENSG00000161960	EIF4A1	100	85.075	ENSJJAG00000001331	-	92	84.390	Jaculus_jaculus
ENSG00000161960	EIF4A1	100	100.000	ENSJJAG00000022783	-	100	99.749	Jaculus_jaculus
ENSG00000161960	EIF4A1	99	82.759	ENSLAFG00000029547	-	100	76.573	Loxodonta_africana
ENSG00000161960	EIF4A1	100	100.000	ENSLAFG00000001107	EIF4A1	100	99.754	Loxodonta_africana
ENSG00000161960	EIF4A1	100	100.000	ENSMFAG00000031996	-	99	97.376	Macaca_fascicularis
ENSG00000161960	EIF4A1	100	100.000	ENSMFAG00000039010	EIF4A1	100	100.000	Macaca_fascicularis
ENSG00000161960	EIF4A1	100	83.761	ENSMFAG00000034128	-	95	75.974	Macaca_fascicularis
ENSG00000161960	EIF4A1	100	83.761	ENSMMUG00000038680	-	99	71.848	Macaca_mulatta
ENSG00000161960	EIF4A1	100	100.000	ENSMMUG00000013499	-	100	100.000	Macaca_mulatta
ENSG00000161960	EIF4A1	100	100.000	ENSMMUG00000007545	-	94	99.545	Macaca_mulatta
ENSG00000161960	EIF4A1	100	84.615	ENSMNEG00000030284	-	95	77.409	Macaca_nemestrina
ENSG00000161960	EIF4A1	100	100.000	ENSMNEG00000035880	EIF4A1	100	99.507	Macaca_nemestrina
ENSG00000161960	EIF4A1	100	84.615	ENSMLEG00000040863	-	99	67.654	Mandrillus_leucophaeus
ENSG00000161960	EIF4A1	100	100.000	ENSMLEG00000032647	EIF4A1	100	100.000	Mandrillus_leucophaeus
ENSG00000161960	EIF4A1	100	100.000	ENSMAUG00000018508	-	96	99.507	Mesocricetus_auratus
ENSG00000161960	EIF4A1	93	69.159	ENSMAUG00000000782	Eif4a1	100	75.874	Mesocricetus_auratus
ENSG00000161960	EIF4A1	100	100.000	ENSMICG00000014759	EIF4A1	100	100.000	Microcebus_murinus
ENSG00000161960	EIF4A1	100	93.162	ENSMICG00000044950	-	95	80.969	Microcebus_murinus
ENSG00000161960	EIF4A1	100	100.000	ENSMOCG00000007064	Eif4a1	100	100.000	Microtus_ochrogaster
ENSG00000161960	EIF4A1	100	99.145	ENSMOCG00000004330	-	100	98.561	Microtus_ochrogaster
ENSG00000161960	EIF4A1	85	94.444	ENSMOCG00000012425	-	100	77.632	Microtus_ochrogaster
ENSG00000161960	EIF4A1	100	100.000	ENSMODG00000007090	EIF4A1	99	98.263	Monodelphis_domestica
ENSG00000161960	EIF4A1	100	100.000	ENSMUSG00000059796	Eif4a1	100	100.000	Mus_musculus
ENSG00000161960	EIF4A1	100	100.000	ENSMPUG00000009529	-	100	99.754	Mustela_putorius_furo
ENSG00000161960	EIF4A1	100	100.000	ENSMLUG00000003415	-	100	99.265	Myotis_lucifugus
ENSG00000161960	EIF4A1	100	71.765	ENSMLUG00000027970	-	96	61.616	Myotis_lucifugus
ENSG00000161960	EIF4A1	100	100.000	ENSNGAG00000018330	Eif4a1	100	100.000	Nannospalax_galili
ENSG00000161960	EIF4A1	95	86.420	ENSNGAG00000017979	-	91	69.231	Nannospalax_galili
ENSG00000161960	EIF4A1	100	100.000	ENSNLEG00000009547	EIF4A1	100	98.775	Nomascus_leucogenys
ENSG00000161960	EIF4A1	100	79.487	ENSNLEG00000029784	-	94	85.959	Nomascus_leucogenys
ENSG00000161960	EIF4A1	100	64.103	ENSNLEG00000034508	-	100	76.357	Nomascus_leucogenys
ENSG00000161960	EIF4A1	100	94.872	ENSNLEG00000018739	-	96	94.595	Nomascus_leucogenys
ENSG00000161960	EIF4A1	100	96.581	ENSNLEG00000027059	-	100	87.186	Nomascus_leucogenys
ENSG00000161960	EIF4A1	100	90.588	ENSNLEG00000000571	-	100	85.961	Nomascus_leucogenys
ENSG00000161960	EIF4A1	100	100.000	ENSMEUG00000010780	EIF4A1	100	98.883	Notamacropus_eugenii
ENSG00000161960	EIF4A1	100	99.145	ENSOPRG00000008591	-	100	96.798	Ochotona_princeps
ENSG00000161960	EIF4A1	100	95.726	ENSODEG00000019586	-	100	95.804	Octodon_degus
ENSG00000161960	EIF4A1	100	100.000	ENSODEG00000017512	-	97	97.990	Octodon_degus
ENSG00000161960	EIF4A1	97	81.013	ENSODEG00000005642	-	99	78.571	Octodon_degus
ENSG00000161960	EIF4A1	100	89.883	ENSODEG00000006150	-	99	87.688	Octodon_degus
ENSG00000161960	EIF4A1	100	99.387	ENSODEG00000012713	-	100	94.335	Octodon_degus
ENSG00000161960	EIF4A1	100	98.824	ENSOANG00000004333	EIF4A1	100	87.023	Ornithorhynchus_anatinus
ENSG00000161960	EIF4A1	100	100.000	ENSOCUG00000010375	EIF4A1	100	100.000	Oryctolagus_cuniculus
ENSG00000161960	EIF4A1	100	92.308	ENSOCUG00000029227	-	92	94.158	Oryctolagus_cuniculus
ENSG00000161960	EIF4A1	100	100.000	ENSOGAG00000008132	-	100	99.510	Otolemur_garnettii
ENSG00000161960	EIF4A1	93	69.620	ENSOGAG00000031869	-	99	62.252	Otolemur_garnettii
ENSG00000161960	EIF4A1	100	100.000	ENSOARG00000014476	EIF4A1	100	99.754	Ovis_aries
ENSG00000161960	EIF4A1	100	98.291	ENSPPAG00000040878	-	86	94.821	Pan_paniscus
ENSG00000161960	EIF4A1	96	79.675	ENSPPAG00000027347	-	99	75.696	Pan_paniscus
ENSG00000161960	EIF4A1	100	100.000	ENSPPAG00000039921	EIF4A1	100	100.000	Pan_paniscus
ENSG00000161960	EIF4A1	100	79.144	ENSPPAG00000035282	-	100	74.779	Pan_paniscus
ENSG00000161960	EIF4A1	100	100.000	ENSPPAG00000035131	-	99	99.727	Pan_paniscus
ENSG00000161960	EIF4A1	100	92.941	ENSPPAG00000038939	-	99	84.673	Pan_paniscus
ENSG00000161960	EIF4A1	100	100.000	ENSPPRG00000006906	EIF4A1	100	100.000	Panthera_pardus
ENSG00000161960	EIF4A1	99	70.909	ENSPPRG00000003400	-	92	65.919	Panthera_pardus
ENSG00000161960	EIF4A1	100	100.000	ENSPTIG00000012373	-	100	100.000	Panthera_tigris_altaica
ENSG00000161960	EIF4A1	100	100.000	ENSPTRG00000008694	EIF4A1	100	100.000	Pan_troglodytes
ENSG00000161960	EIF4A1	96	78.862	ENSPTRG00000050879	-	99	75.696	Pan_troglodytes
ENSG00000161960	EIF4A1	100	92.941	ENSPTRG00000048517	-	99	84.673	Pan_troglodytes
ENSG00000161960	EIF4A1	100	98.291	ENSPTRG00000043870	-	91	93.606	Pan_troglodytes
ENSG00000161960	EIF4A1	100	98.291	ENSPTRG00000051629	-	100	95.732	Pan_troglodytes
ENSG00000161960	EIF4A1	100	79.144	ENSPTRG00000048695	-	100	74.779	Pan_troglodytes
ENSG00000161960	EIF4A1	100	100.000	ENSPANG00000024093	EIF4A1	100	100.000	Papio_anubis
ENSG00000161960	EIF4A1	100	69.939	ENSPANG00000033623	-	92	71.233	Papio_anubis
ENSG00000161960	EIF4A1	100	100.000	ENSPSIG00000008719	EIF4A1	88	97.990	Pelodiscus_sinensis
ENSG00000161960	EIF4A1	100	93.162	ENSPMGG00000000195	EIF4A1	96	87.013	Periophthalmus_magnuspinnatus
ENSG00000161960	EIF4A1	100	96.269	ENSPEMG00000015813	-	91	96.119	Peromyscus_maniculatus_bairdii
ENSG00000161960	EIF4A1	100	92.365	ENSPEMG00000007594	-	100	92.365	Peromyscus_maniculatus_bairdii
ENSG00000161960	EIF4A1	100	100.000	ENSPEMG00000009100	Eif4a1	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000161960	EIF4A1	100	100.000	ENSPCIG00000028856	EIF4A1	100	98.718	Phascolarctos_cinereus
ENSG00000161960	EIF4A1	100	100.000	ENSPPYG00000007926	EIF4A1	100	100.000	Pongo_abelii
ENSG00000161960	EIF4A1	100	100.000	ENSPCAG00000012966	EIF4A1	100	99.754	Procavia_capensis
ENSG00000161960	EIF4A1	100	97.647	ENSPCOG00000026844	-	99	91.608	Propithecus_coquereli
ENSG00000161960	EIF4A1	100	100.000	ENSPCOG00000012349	EIF4A1	100	100.000	Propithecus_coquereli
ENSG00000161960	EIF4A1	100	100.000	ENSPVAG00000016297	EIF4A1	100	99.754	Pteropus_vampyrus
ENSG00000161960	EIF4A1	100	100.000	ENSRNOG00000030628	Eif4a1	100	100.000	Rattus_norvegicus
ENSG00000161960	EIF4A1	100	98.824	ENSRBIG00000021813	-	99	87.688	Rhinopithecus_bieti
ENSG00000161960	EIF4A1	100	84.615	ENSRBIG00000041807	-	94	72.297	Rhinopithecus_bieti
ENSG00000161960	EIF4A1	100	96.481	ENSRBIG00000038269	-	100	96.481	Rhinopithecus_bieti
ENSG00000161960	EIF4A1	100	100.000	ENSRBIG00000044495	EIF4A1	100	100.000	Rhinopithecus_bieti
ENSG00000161960	EIF4A1	100	84.127	ENSRBIG00000040184	-	99	81.972	Rhinopithecus_bieti
ENSG00000161960	EIF4A1	100	100.000	ENSRROG00000032175	EIF4A1	100	100.000	Rhinopithecus_roxellana
ENSG00000161960	EIF4A1	98	88.696	ENSRROG00000028953	-	99	85.634	Rhinopithecus_roxellana
ENSG00000161960	EIF4A1	100	97.647	ENSRROG00000008751	-	95	90.169	Rhinopithecus_roxellana
ENSG00000161960	EIF4A1	100	97.436	ENSRROG00000004632	-	100	93.727	Rhinopithecus_roxellana
ENSG00000161960	EIF4A1	100	100.000	ENSRROG00000028890	-	100	89.723	Rhinopithecus_roxellana
ENSG00000161960	EIF4A1	98	79.874	ENSSBOG00000020778	-	100	77.340	Saimiri_boliviensis_boliviensis
ENSG00000161960	EIF4A1	100	100.000	ENSSBOG00000023267	EIF4A1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000161960	EIF4A1	100	93.284	ENSSBOG00000027332	-	100	85.961	Saimiri_boliviensis_boliviensis
ENSG00000161960	EIF4A1	93	66.822	ENSSBOG00000021265	-	100	72.028	Saimiri_boliviensis_boliviensis
ENSG00000161960	EIF4A1	99	87.288	ENSSBOG00000032580	-	99	85.294	Saimiri_boliviensis_boliviensis
ENSG00000161960	EIF4A1	100	98.788	ENSSHAG00000015756	EIF4A1	100	98.284	Sarcophilus_harrisii
ENSG00000161960	EIF4A1	100	100.000	ENSSARG00000006017	EIF4A1	100	100.000	Sorex_araneus
ENSG00000161960	EIF4A1	100	100.000	ENSSPUG00000018309	EIF4A1	100	98.492	Sphenodon_punctatus
ENSG00000161960	EIF4A1	100	100.000	ENSSSCG00000017957	EIF4A1	100	100.000	Sus_scrofa
ENSG00000161960	EIF4A1	85	73.737	ENSSSCG00000035903	-	100	54.545	Sus_scrofa
ENSG00000161960	EIF4A1	98	86.087	ENSTRUG00000002188	EIF4A1	87	79.064	Takifugu_rubripes
ENSG00000161960	EIF4A1	98	85.217	ENSTNIG00000004408	-	100	77.740	Tetraodon_nigroviridis
ENSG00000161960	EIF4A1	98	71.304	ENSTNIG00000017079	-	100	69.296	Tetraodon_nigroviridis
ENSG00000161960	EIF4A1	100	73.504	ENSTNIG00000006865	-	99	71.540	Tetraodon_nigroviridis
ENSG00000161960	EIF4A1	100	81.176	ENSTNIG00000004366	-	84	80.000	Tetraodon_nigroviridis
ENSG00000161960	EIF4A1	97	61.947	ENSTNIG00000000303	-	98	51.064	Tetraodon_nigroviridis
ENSG00000161960	EIF4A1	100	74.359	ENSTNIG00000007405	-	99	69.438	Tetraodon_nigroviridis
ENSG00000161960	EIF4A1	100	100.000	ENSTTRG00000010208	EIF4A1	100	100.000	Tursiops_truncatus
ENSG00000161960	EIF4A1	100	100.000	ENSUAMG00000003583	EIF4A1	100	100.000	Ursus_americanus
ENSG00000161960	EIF4A1	100	100.000	ENSUMAG00000016558	-	99	93.902	Ursus_maritimus
ENSG00000161960	EIF4A1	100	100.000	ENSVPAG00000000142	-	100	99.676	Vicugna_pacos
ENSG00000161960	EIF4A1	100	98.824	ENSVVUG00000018822	-	96	96.885	Vulpes_vulpes
ENSG00000161960	EIF4A1	100	97.436	ENSXETG00000020123	eif4a1	100	95.074	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000339	RNA cap binding	3215517.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0003729	mRNA binding	3215517.	TAS	Function
GO:0003743	translation initiation factor activity	-	IEA	Function
GO:0004004	ATP-dependent RNA helicase activity	-	IEA	Function
GO:0004386	helicase activity	3215517.	TAS	Function
GO:0005515	protein binding	9548260.16166382.16932749.17284590.18296639.18606994.19203580.19204291.22678294.23023399.23478064.24413684.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	12426392.	IDA	Component
GO:0005737	cytoplasm	12426392.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006413	translational initiation	-	TAS	Process
GO:0008135	translation factor activity, RNA binding	3215517.10880459.	TAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016281	eukaryotic translation initiation factor 4F complex	9168945.	TAS	Component
GO:0070062	extracellular exosome	20458337.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.