EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25578727	The deubiquitinating enzyme USP24 is a regulator of the UV damage response.	Cell Rep	2015 Jan 13	Zhang L	doi: 10.1016/j.celrep.2014.12.024
25814533	Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.	Blood	2015 Jun 4	Peterson LF	doi: 10.1182/blood-2014-10-605584
27991932	EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis.	Oncogene	2017 May 25	Wang SA	doi: 10.1038/onc.2016.445
26568301	Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.	Oncogene	2016 Jul 14	Wang YC	doi: 10.1038/onc.2015.432
30266897	USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy.	Nat Commun	2018 Sep 28	Wang YC	doi: 10.1038/s41467-018-06178-1.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	55103949	Missense_Mutation	rs745333534	N1651S	0.19
BLCA	chr1	55096567	Missense_Mutation	NA	D1998Y	0.73
BLCA	chr1	55069027	3'UTR	novel		0.13
BLCA	chr1	55172484	Missense_Mutation	novel	E199K	0.21
BLCA	chr1	55097088	Nonsense_Mutation	novel	R1934*	0.33
BLCA	chr1	55089741	Splice_Site	novel	X2185_splice	0.5
BLCA	chr1	55156954	Silent	novel	K480K	0.1
BLCA	chr1	55138967	Missense_Mutation	novel	E932K	0.36
BLCA	chr1	55129544	Missense_Mutation	NA	D1190N	0.11
BLCA	chr1	55083363	Missense_Mutation	NA	Q2295P	0.77
BLCA	chr1	55162236	Missense_Mutation	novel	G319E	0.15
BLCA	chr1	55159026	In_Frame_Ins	novel	V359_S360insILI	0.14
BLCA	chr1	55141644	Missense_Mutation	novel	V908I	0.37
BLCA	chr1	55146991	Missense_Mutation	rs751444448	R730C	0.39
BLCA	chr1	55092114	Missense_Mutation	novel	H2155N	0.35
BLCA	chr1	55172412	Missense_Mutation	NA	P223A	0.25
BLCA	chr1	55107320	Missense_Mutation	novel	A1561T	0.07
BLCA	chr1	55107321	Frame_Shift_Ins	novel	*E1560Dfs34**	0.08
BLCA	chr1	55085950	Missense_Mutation	novel	Q2253E	0.53
BRCA	chr1	55159655	Missense_Mutation	rs150880897	I342V	0.4
BRCA	chr1	55171665	Missense_Mutation	rs748267511	D239G	0.16
BRCA	chr1	55123486	Missense_Mutation	NA	L1413F	0.37
BRCA	chr1	55147016	Nonsense_Mutation	novel	*E721Dfs7**	0.14
BRCA	chr1	55100949	Missense_Mutation	NA	D1721N	0.52
BRCA	chr1	55123475	Silent	rs766386767	T1416T	0.37
BRCA	chr1	55069019	3'UTR	novel		0.26
BRCA	chr1	55154259	Missense_Mutation	novel	L558M	0.09
BRCA	chr1	55123559	Silent	NA	L1388L	0.24
BRCA	chr1	55089667	Missense_Mutation	novel	V2210I	0.12
BRCA	chr1	55154155	Silent	NA	R592R	0.15
BRCA	chr1	55107268	Missense_Mutation	novel	S1578L	0.11
CESC	chr1	55072792	Missense_Mutation	NA	Q2532H	0.23
CESC	chr1	55120752	Missense_Mutation	rs370480612	R1451H	0.3
CESC	chr1	55103929	Nonsense_Mutation	NA	E1658*	0.36
CESC	chr1	55158888	Missense_Mutation	NA	S406Y	0.46
CESC	chr1	55095277	Nonsense_Mutation	rs761804088	Q2061*	0.34
CESC	chr1	55120652	Silent	NA	L1484L	0.33
CESC	chr1	55147736	Silent	novel	I677I	0.28
CESC	chr1	55158927	Missense_Mutation	rs567412757	R393H	0.38
CESC	chr1	55215061	Nonsense_Mutation	NA	S18*	0.35
COAD	chr1	55071861	Missense_Mutation	NA	S2585P	0.28
COAD	chr1	55098488	Missense_Mutation	NA	D1814G	0.09
COAD	chr1	55071908	Missense_Mutation	novel	A2569V	0.49
COAD	chr1	55129544	Missense_Mutation	NA	D1190N	0.19
COAD	chr1	55156962	Frame_Shift_Del	novel	*I478Ffs12**	0.09
COAD	chr1	55148487	Silent	novel	K648K	0.24
COAD	chr1	55096995	Nonsense_Mutation	novel	Q1965*	0.38
COAD	chr1	55097699	Missense_Mutation	novel	T1872A	0.08
COAD	chr1	55143043	Missense_Mutation	novel	A839V	0.11
COAD	chr1	55129485	Silent	rs139894795	G1209G	0.19
COAD	chr1	55097625	Silent	NA	R1896R	0.21
COAD	chr1	55107346	Missense_Mutation	novel	R1552H	0.36
COAD	chr1	55107362	Missense_Mutation	novel	N1547H	0.05
COAD	chr1	55100913	Frame_Shift_Del	NA	*Y1733Tfs10**	0.35
COAD	chr1	55141655	Missense_Mutation	NA	A904V	0.3
COAD	chr1	55097087	Missense_Mutation	rs373439536	R1934Q	0.39
COAD	chr1	55092042	Missense_Mutation	NA	R2179W	0.45
COAD	chr1	55134347	Missense_Mutation	novel	A1090T	0.49
COAD	chr1	55078571	Silent	novel	E2427E	0.2
COAD	chr1	55124567	Missense_Mutation	rs752275725	A1341V	0.28
COAD	chr1	55096554	Missense_Mutation	NA	E2002G	0.31
COAD	chr1	55125467	Silent	novel	R1271R	0.3
COAD	chr1	55137874	Missense_Mutation	rs772334656	R987W	0.2
COAD	chr1	55144177	Frame_Shift_Ins	novel	E797*	0.32
COAD	chr1	55125518	Silent	rs573136414	T1254T	0.18
COAD	chr1	55083835	Silent	rs766228275	D2273D	0.41
COAD	chr1	55134372	Silent	rs368984047	N1081N	0.08
COAD	chr1	55137671	Silent	NA	D1015D	0.18
COAD	chr1	55120753	Missense_Mutation	NA	R1451C	0.48
COAD	chr1	55097695	Missense_Mutation	novel	C1873S	0.17
COAD	chr1	55121457	Silent	novel	L1442L	0.25
COAD	chr1	55144178	Frame_Shift_Del	novel	*F796Lfs4**	0.37
COAD	chr1	55099810	Missense_Mutation	novel	F1777L	0.11
COAD	chr1	55124490	Nonsense_Mutation	NA	R1367*	0.16
COAD	chr1	55157029	Nonsense_Mutation	NA	Y455*	0.2
COAD	chr1	55099821	Missense_Mutation	novel	A1774T	0.33
COAD	chr1	55148566	Nonsense_Mutation	novel	S622delins*	0.08
COAD	chr1	55125460	Nonsense_Mutation	rs748220151	R1274*	0.17
COAD	chr1	55125535	Missense_Mutation	NA	G1249R	0.31
COAD	chr1	55137617	Silent	NA	K1033K	0.14
DLBC	chr1	55083361	Missense_Mutation	novel	G2296R	0.13
DLBC	chr1	55121453	Missense_Mutation	rs769403889	G1444R	0.25
DLBC	chr1	55157266	Missense_Mutation	novel	I444M	0.62
ESCA	chr1	55125505	Missense_Mutation	rs761278282	D1259N	0.47
ESCA	chr1	55146937	Missense_Mutation	novel	D748Y	0.4
ESCA	chr1	55148500	Missense_Mutation	novel	R644H	0.14
ESCA	chr1	55107379	Missense_Mutation	novel	E1541A	0.13
ESCA	chr1	55104015	Missense_Mutation	novel	S1629T	0.29
ESCA	chr1	55129571	Silent	novel	L1181L	0.15
ESCA	chr1	55156954	Missense_Mutation	novel	K480N	0.18
GBM	chr1	55083882	Missense_Mutation	novel	S2258R	0.15
GBM	chr1	55089736	Missense_Mutation	novel	D2187N	0.29
GBM	chr1	55097149	Missense_Mutation	novel	E1913D	0.24
GBM	chr1	55098077	Missense_Mutation	novel	R1821C	0.41
GBM	chr1	55124520	Missense_Mutation	novel	E1357K	0.45
GBM	chr1	55141715	Missense_Mutation	novel	L884R	0.56
GBM	chr1	55078619	Silent	rs770624443	S2411S	0.4
GBM	chr1	55123511	Silent	novel	S1404S	0.47
GBM	chr1	55137594	Missense_Mutation	novel	S1041Y	0.16
GBM	chr1	55147749	Missense_Mutation	rs779790897	T673M	0.17
HNSC	chr1	55079653	Missense_Mutation	novel	G2362D	0.11
HNSC	chr1	55146990	Missense_Mutation	NA	R730H	0.13
HNSC	chr1	55098487	Silent	novel	D1814D	0.13
HNSC	chr1	55069080	Missense_Mutation	rs752787485	E2610K	0.37
HNSC	chr1	55094048	Silent	novel	S2081S	0.31
HNSC	chr1	55095382	Missense_Mutation	novel	D2026N	0.09
HNSC	chr1	55132557	Silent	rs775261308	L1175L	0.42
HNSC	chr1	55079556	Silent	novel	G2394G	0.22
HNSC	chr1	55134145	Silent	rs370042721	R1102R	0.33
KIRC	chr1	55176442	Splice_Region	NA	G164G	0.32
KIRC	chr1	55100881	Missense_Mutation	NA	M1743I	0.32
KIRC	chr1	55154132	Missense_Mutation	NA	E600A	0.31
KIRC	chr1	55068898	3'UTR	novel		0.3
KIRC	chr1	55172395	Silent	NA	L228L	0.21
KIRC	chr1	55176444	Splice_Site	NA	X164_splice	0.21
KIRC	chr1	55156984	Silent	novel	L470L	0.13
KIRC	chr1	55085953	Frame_Shift_Del	novel	*Y2252Ifs5**	0.16
KIRP	chr1	55124590	Frame_Shift_Del	novel	D1326*	0.11
KIRP	chr1	55147004	Silent	NA	Y725Y	0.38
KIRP	chr1	55138683	Silent	novel	H951H	0.48
KIRP	chr1	55104016	Missense_Mutation	NA	S1629G	0.25
KIRP	chr1	55137860	Silent	novel	A991A	0.12
LAML	chr1	55123446	Splice_Site	NA	X1426_splice	0.38
LGG	chr1	55172491	Nonsense_Mutation	NA	W196*	0.21
LGG	chr1	55095360	Missense_Mutation	novel	N2033T	0.41
LGG	chr1	55097670	Silent	novel	L1881L	0.37
LGG	chr1	55095295	Nonsense_Mutation	NA	R2055*	0.29
LIHC	chr1	55158985	Missense_Mutation	rs374277857	R374C	0.34
LIHC	chr1	55138717	Missense_Mutation	novel	D940V	0.31
LIHC	chr1	55083814	Frame_Shift_Ins	novel	*C2281Lfs18**	0.52
LIHC	chr1	55107419	Missense_Mutation	NA	E1528K	0.1
LIHC	chr1	55158954	Missense_Mutation	rs529133449	D384G	0.06
LIHC	chr1	55144193	Missense_Mutation	novel	L791F	0.35
LIHC	chr1	55154176	Silent	novel	A585A	0.22
LUAD	chr1	55097977	Missense_Mutation	NA	S1854I	0.42
LUAD	chr1	55147000	Missense_Mutation	novel	G727C	0.1
LUAD	chr1	55124555	Missense_Mutation	rs368254067	R1345Q	0.19
LUAD	chr1	55171616	Missense_Mutation	novel	W255C	0.27
LUAD	chr1	55101659	Frame_Shift_Del	novel	L1691*	0.21
LUAD	chr1	55096535	Silent	novel	C2008C	0.36
LUAD	chr1	55098051	Missense_Mutation	novel	N1829K	0.12
LUAD	chr1	55079638	Missense_Mutation	rs778463727	R2367Q	0.14
LUAD	chr1	55097987	Missense_Mutation	novel	L1851I	0.26
LUAD	chr1	55154257	Silent	novel	L558L	0.23
LUAD	chr1	55107257	Frame_Shift_Del	novel	*A1582Qfs15**	0.1
LUAD	chr1	55132668	Silent	NA	S1138S	0.32
LUAD	chr1	55123535	Silent	NA	Q1396Q	0.71
LUAD	chr1	55100903	Missense_Mutation	NA	Q1736L	0.11
LUAD	chr1	55156973	Missense_Mutation	NA	E474V	0.33
LUAD	chr1	55125505	Missense_Mutation	rs761278282	D1259N	0.38
LUAD	chr1	55079631	Silent	novel	P2369P	0.36
LUAD	chr1	55125751	Frame_Shift_Del	novel	V1215*	0.31
LUAD	chr1	55123473	Missense_Mutation	novel	C1417F	0.24
LUAD	chr1	55141669	Missense_Mutation	NA	M899I	0.14
LUAD	chr1	55138998	Silent	NA	L921L	0.28
LUAD	chr1	55073864	Missense_Mutation	NA	Y2497C	0.43
LUAD	chr1	55097008	Silent	rs776536182	I1960I	0.5
LUAD	chr1	55083353	Missense_Mutation	novel	R2298S	0.06
LUSC	chr1	55078641	Missense_Mutation	NA	A2404G	0.14
LUSC	chr1	55086003	Missense_Mutation	rs764984366	R2235Q	0.54
LUSC	chr1	55137839	Silent	NA	V998V	0.12
LUSC	chr1	55143050	Nonsense_Mutation	NA	E837*	0.6
LUSC	chr1	55123570	Missense_Mutation	novel	P1385T	0.35
LUSC	chr1	55083292	Missense_Mutation	novel	A2319S	0.71
LUSC	chr1	55096986	Missense_Mutation	rs778750018	A1968T	0.14
LUSC	chr1	55103908	Frame_Shift_Ins	novel	*Q1665Sfs30**	0.4
LUSC	chr1	55107321	Frame_Shift_Ins	novel	*E1560Dfs34**	0.04
LUSC	chr1	55154767	Silent	NA	S486S	0.16
LUSC	chr1	55107290	Missense_Mutation	NA	R1571C	0.25
LUSC	chr1	55172431	Frame_Shift_Del	novel	*E217Rfs3**	0.22
LUSC	chr1	55097698	Missense_Mutation	NA	T1872S	0.24
LUSC	chr1	55081417	Missense_Mutation	novel	R2328L	0.18
LUSC	chr1	55069103	Missense_Mutation	novel	S2602L	0.53
LUSC	chr1	55100925	Missense_Mutation	NA	D1729N	0.1
LUSC	chr1	55172462	Missense_Mutation	novel	N206S	0.22
LUSC	chr1	55137892	Missense_Mutation	novel	E981K	0.27
LUSC	chr1	55079592	Silent	NA	H2382H	0.23
LUSC	chr1	55124489	Missense_Mutation	novel	R1367L	0.07
LUSC	chr1	55086016	Missense_Mutation	novel	V2231L	0.35
LUSC	chr1	55098007	Missense_Mutation	novel	Q1844L	0.18
LUSC	chr1	55141670	Frame_Shift_Ins	novel	*M899Nfs19**	0.45
MESO	chr1	55132637	Nonsense_Mutation	novel	Q1149*	0.36
OV	chr1	55137636	Missense_Mutation	NA	E1027G	0.47
OV	chr1	55159021	Missense_Mutation	NA	P362A	0.47
OV	chr1	55079604	Silent	novel	L2378L	0.08
OV	chr1	55078591	Missense_Mutation	NA	Y2421H	0.74
OV	chr1	55125400	Missense_Mutation	NA	S1294T	0.27
PAAD	chr1	55096542	Missense_Mutation	novel	Y2006S	0.04
PAAD	chr1	55097661	Silent	novel	H1884H	0.11
PAAD	chr1	55103919	Missense_Mutation	novel	S1661Y	0.19
PAAD	chr1	55123553	Silent	rs373311667	A1390A	0.25
PAAD	chr1	55154694	Missense_Mutation	novel	H511N	0.08
PRAD	chr1	55107261	Missense_Mutation	novel	C1580W	0.09
PRAD	chr1	55103941	Missense_Mutation	novel	I1654L	0.71
PRAD	chr1	55071920	Missense_Mutation	novel	T2565M	0.5
READ	chr1	55146031	Missense_Mutation	NA	L777I	0.17
READ	chr1	55157270	Missense_Mutation	novel	S443L	0.21
READ	chr1	55176413	In_Frame_Del	NA	R174del	0.48
READ	chr1	55157365	Silent	NA	T411T	0.23
READ	chr1	55157259	Missense_Mutation	NA	E447K	0.08
READ	chr1	55120753	Missense_Mutation	NA	R1451C	0.36
READ	chr1	55156994	Missense_Mutation	NA	G467D	0.23
SARC	chr1	55069091	Missense_Mutation	novel	M2606T	0.14
SARC	chr1	55101672	Missense_Mutation	novel	S1686L	0.46
SARC	chr1	55071885	Frame_Shift_Ins	novel	*E2577Rfs7**	0.27
SKCM	chr1	55083293	Silent	NA	G2318G	0.25
SKCM	chr1	55097716	Missense_Mutation	NA	R1866K	0.36
SKCM	chr1	55132653	Silent	NA	S1143S	0.35
SKCM	chr1	55132654	Missense_Mutation	rs780990315	S1143F	0.35
SKCM	chr1	55137597	Missense_Mutation	novel	P1040L	0.65
SKCM	chr1	55134156	Silent	novel	L1099L	0.5
SKCM	chr1	55096555	In_Frame_Del	novel	T1992_E2002delinsK	0.44
SKCM	chr1	55124564	Missense_Mutation	novel	A1342V	0.29
SKCM	chr1	55072826	Missense_Mutation	novel	S2521F	0.11
SKCM	chr1	55106225	Missense_Mutation	novel	F1601V	0.11
SKCM	chr1	55104001	Nonsense_Mutation	novel	R1634*	0.62
SKCM	chr1	55104002	Silent	novel	S1633S	0.62
SKCM	chr1	55107309	Silent	NA	I1564I	0.14
SKCM	chr1	55134138	Silent	novel	L1105L	0.23
SKCM	chr1	55134108	Nonsense_Mutation	NA	Q1115*	0.62
SKCM	chr1	55081329	Silent	rs575176302	R2357R	0.14
SKCM	chr1	55081330	Missense_Mutation	rs201018293	R2357K	0.14
SKCM	chr1	55132675	Missense_Mutation	NA	S1136F	0.26
SKCM	chr1	55069094	Missense_Mutation	novel	P2605L	0.22
SKCM	chr1	55071860	Missense_Mutation	novel	S2585L	0.24
SKCM	chr1	55094061	Missense_Mutation	NA	S2077L	0.15
SKCM	chr1	55077241	Missense_Mutation	novel	E2458D	0.5
SKCM	chr1	55098532	Silent	novel	K1799K	0.24
SKCM	chr1	55132654	Missense_Mutation	rs780990315	S1143F	0.47
SKCM	chr1	55068972	3'UTR	rs565183633		0.65
SKCM	chr1	55079633	Missense_Mutation	rs748936807	P2369S	0.22
SKCM	chr1	55125399	Missense_Mutation	NA	S1294F	0.16
SKCM	chr1	55138685	Missense_Mutation	novel	H951Y	0.48
SKCM	chr1	55129543	Frame_Shift_Del	novel	*K1184Mfs22**	0.08
SKCM	chr1	55129496	Missense_Mutation	novel	L1206F	0.6
SKCM	chr1	55120719	Missense_Mutation	NA	S1462N	1
SKCM	chr1	55100910	Nonsense_Mutation	novel	Q1734*	0.25
STAD	chr1	55100954	Missense_Mutation	NA	S1719L	0.08
STAD	chr1	55134138	Silent	novel	L1105L	0.15
STAD	chr1	55134139	Silent	novel	L1104L	0.15
STAD	chr1	55158985	Missense_Mutation	rs374277857	R374C	0.47
STAD	chr1	55097096	Missense_Mutation	NA	E1931G	0.33
STAD	chr1	55147707	Missense_Mutation	rs201685422	A687V	0.35
STAD	chr1	55158985	Missense_Mutation	rs374277857	R374C	0.44
STAD	chr1	55094043	Missense_Mutation	rs368696129	R2083Q	0.29
STAD	chr1	55068887	3'UTR	novel		0.42
STAD	chr1	55138990	Missense_Mutation	NA	I924S	0.24
STAD	chr1	55098076	Missense_Mutation	NA	R1821H	0.39
STAD	chr1	55154187	Missense_Mutation	NA	D582Y	0.13
STAD	chr1	55137633	Missense_Mutation	novel	Q1028L	0.38
STAD	chr1	55137634	Missense_Mutation	novel	Q1028K	0.39
STAD	chr1	55093988	Frame_Shift_Del	novel	*G2102Afs19**	0.11
STAD	chr1	55125339	Missense_Mutation	NA	A1314V	0.07
STAD	chr1	55171596	Missense_Mutation	novel	G262E	0.31
STAD	chr1	55158946	Nonsense_Mutation	NA	R387*	0.19
STAD	chr1	55094020	Missense_Mutation	NA	R2091W	0.31
STAD	chr1	55097088	Nonsense_Mutation	novel	R1934*	0.23
THCA	chr1	55138986	In_Frame_Ins	novel	E925_R926insK	0.08
THCA	chr1	55138988	Frame_Shift_Ins	novel	*E925Kfs12**	0.08
THCA	chr1	55147011	Missense_Mutation	novel	T723I	0.09
UCEC	chr1	55098037	Missense_Mutation	NA	S1834Y	0.31
UCEC	chr1	55125533	Silent	novel	G1249G	0.27
UCEC	chr1	55137850	Missense_Mutation	novel	C995R	0.19
UCEC	chr1	55158984	Missense_Mutation	novel	R374H	0.17
UCEC	chr1	55123512	Missense_Mutation	NA	S1404L	0.34
UCEC	chr1	55124490	Nonsense_Mutation	NA	R1367*	0.42
UCEC	chr1	55072857	Missense_Mutation	novel	P2511S	0.36
UCEC	chr1	55100863	Silent	novel	Y1749Y	0.42
UCEC	chr1	55110190	Missense_Mutation	novel	L1522P	0.37
UCEC	chr1	55123527	Missense_Mutation	novel	V1399A	0.17
UCEC	chr1	55146031	Missense_Mutation	NA	L777I	0.41
UCEC	chr1	55157041	Silent	rs527266421	D451D	0.31
UCEC	chr1	55098531	Missense_Mutation	NA	N1800Y	0.13
UCEC	chr1	55123540	Nonsense_Mutation	NA	R1395*	0.42
UCEC	chr1	55143046	Missense_Mutation	NA	I838S	0.38
UCEC	chr1	55103937	Missense_Mutation	novel	I1655S	0.32
UCEC	chr1	55100891	Missense_Mutation	novel	G1740E	0.41
UCEC	chr1	55137810	Missense_Mutation	novel	S1008N	0.41
UCEC	chr1	55154175	Missense_Mutation	novel	V586M	0.39
UCEC	chr1	55154271	Missense_Mutation	rs375612644	V554I	0.46
UCEC	chr1	55159015	Missense_Mutation	novel	L364F	0.43
UCEC	chr1	55075519	Missense_Mutation	rs200850930	I2462T	0.51
UCEC	chr1	55098081	Silent	rs753231656	Y1819Y	0.22
UCEC	chr1	55103967	Missense_Mutation	NA	A1645D	0.22
UCEC	chr1	55137665	Missense_Mutation	novel	K1017N	0.07
UCEC	chr1	55144185	Frame_Shift_Ins	novel	*T794Rfs10**	0.08
UCEC	chr1	55095290	Silent	NA	V2056V	0.24
UCEC	chr1	55097666	Missense_Mutation	NA	I1883V	0.33
UCEC	chr1	55134147	Missense_Mutation	NA	R1102W	0.17
UCEC	chr1	55171568	Silent	rs375664136	S271S	0.27
UCEC	chr1	55141706	Missense_Mutation	NA	P887L	0.3
UCEC	chr1	55081341	Silent	novel	V2353V	0.14
UCEC	chr1	55157316	Missense_Mutation	novel	D428Y	0.16
UCEC	chr1	55158888	Missense_Mutation	novel	S406F	0.38
UCEC	chr1	55154250	Missense_Mutation	NA	L561I	0.39
UCEC	chr1	55157334	Missense_Mutation	NA	S422P	0.09
UCEC	chr1	55141705	Frame_Shift_Del	novel	*T888Lfs2**	0.36
UCEC	chr1	55098541	Missense_Mutation	novel	Q1796H	0.31
UCEC	chr1	55147775	Missense_Mutation	NA	K664N	0.32
UCEC	chr1	55098004	Missense_Mutation	novel	F1845C	0.33
UCEC	chr1	55142999	Missense_Mutation	novel	L854I	0.35
UCEC	chr1	55098080	Nonsense_Mutation	novel	E1820*	0.38
UCEC	chr1	55134346	Missense_Mutation	novel	A1090V	0.35
UCEC	chr1	55171594	Missense_Mutation	novel	N263D	0.07
UCEC	chr1	55094029	Missense_Mutation	novel	N2088D	0.31
UCEC	chr1	55158928	Missense_Mutation	novel	R393C	0.48
UCEC	chr1	55132701	Splice_Site	novel	X1128_splice	0.31
UCEC	chr1	55158888	Missense_Mutation	NA	S406Y	0.42
UCEC	chr1	55158928	Missense_Mutation	novel	R393C	0.34
UCEC	chr1	55100947	Missense_Mutation	novel	D1721E	0.37
UCEC	chr1	55103971	Missense_Mutation	novel	L1644V	0.33
UCEC	chr1	55120701	Missense_Mutation	novel	A1468V	0.41
UCEC	chr1	55138700	Nonsense_Mutation	rs755280773	R946*	0.45
UCEC	chr1	55144177	Frame_Shift_Ins	novel	E797*	0.35
UCEC	chr1	55125676	Missense_Mutation	novel	L1240I	0.52
UCEC	chr1	55134153	Nonsense_Mutation	novel	R1100*	0.51
UCEC	chr1	55125519	Missense_Mutation	rs201849007	T1254M	0.39
UCEC	chr1	55096981	Silent	NA	G1969G	0.07
UCEC	chr1	55068913	3'UTR	novel		0.26
UCEC	chr1	55086034	Missense_Mutation	NA	F2225V	0.3
UCEC	chr1	55099810	Missense_Mutation	novel	F1777L	0.37
UCEC	chr1	55158999	Missense_Mutation	novel	K369T	0.45
UCEC	chr1	55166580	Missense_Mutation	novel	D283E	0.29
UCEC	chr1	55171654	Missense_Mutation	novel	H243N	0.32
UCEC	chr1	55097036	Missense_Mutation	novel	T1951I	0.32
UCEC	chr1	55125392	Silent	novel	R1296R	0.29
UCEC	chr1	55092086	In_Frame_Ins	novel	V2164delinsDM	0.1
UCEC	chr1	55092087	Frame_Shift_Ins	novel	*V2164Tfs28**	0.09
UCEC	chr1	55137904	In_Frame_Ins	novel	E976_A977insTNMEASEAGVVRE	0.08
UCEC	chr1	55120615	Missense_Mutation	novel	M1497V	0.16
UCEC	chr1	55134147	Missense_Mutation	NA	R1102W	0.24
UCEC	chr1	55144143	Missense_Mutation	novel	R808I	0.5
UCEC	chr1	55124621	Missense_Mutation	novel	E1323G	0.33
UCEC	chr1	55124515	Silent	NA	S1358S	0.14
UCEC	chr1	55154691	Silent	novel	L512L	0.42
UCEC	chr1	55071835	Silent	rs372744706	N2593N	0.32
UCEC	chr1	55097686	Missense_Mutation	novel	S1876Y	0.42
UCEC	chr1	55098017	Missense_Mutation	novel	S1841P	0.28
UCEC	chr1	55103980	Missense_Mutation	novel	L1641I	0.5
UCEC	chr1	55120654	Missense_Mutation	novel	L1484F	0.32
UCEC	chr1	55097666	Missense_Mutation	NA	I1883V	0.35
UCEC	chr1	55073872	Silent	novel	S2494S	0.27
UCEC	chr1	55095295	Nonsense_Mutation	NA	R2055*	0.29
UCEC	chr1	55156994	Missense_Mutation	NA	G467D	0.21
UCEC	chr1	55166599	Missense_Mutation	novel	P277H	0.13
UCEC	chr1	55092086	In_Frame_Ins	novel	V2164delinsESPQRPISIDM	0.09
UCEC	chr1	55144185	Frame_Shift_Ins	novel	*T794Rfs10**	0.08
UCEC	chr1	55158941	Silent	novel	L388L	0.17
UCEC	chr1	55071816	Nonsense_Mutation	novel	Q2600*	0.13
UCEC	chr1	55137583	Missense_Mutation	NA	A1045S	0.17
UCEC	chr1	55159684	Missense_Mutation	NA	P332H	0.4
UCEC	chr1	55083855	Missense_Mutation	novel	L2267F	0.38
UCEC	chr1	55097646	Silent	NA	G1889G	0.32
UCEC	chr1	55079589	Silent	NA	E2383E	0.25
UCEC	chr1	55162197	Splice_Site	novel	X331_splice	0.41
UCEC	chr1	55125460	Nonsense_Mutation	rs748220151	R1274*	0.22
UCEC	chr1	55099867	Missense_Mutation	NA	I1758M	0.41
UCEC	chr1	55146988	Missense_Mutation	NA	A731T	0.3
UCEC	chr1	55101620	Silent	novel	V1703V	0.63
UCEC	chr1	55142785	Missense_Mutation	novel	S864Y	0.32
UCEC	chr1	55071905	In_Frame_Ins	novel	T2570delinsIRNTDGGP	0.04
UCEC	chr1	55129485	Silent	rs139894795	G1209G	0.22
UCEC	chr1	55154148	Missense_Mutation	novel	I595V	0.27
UCEC	chr1	55157031	Missense_Mutation	NA	Y455H	0.27
UCEC	chr1	55141643	Missense_Mutation	novel	V908A	0.5
UCEC	chr1	55078636	Missense_Mutation	NA	R2406W	0.39
UCEC	chr1	55162265	Splice_Site	NA	X310_splice	0.29
UCEC	chr1	55172457	Silent	NA	L208L	0.1
UCEC	chr1	55096986	Missense_Mutation	rs778750018	A1968T	0.18
UCEC	chr1	55095372	Missense_Mutation	rs775319928	R2029Q	0.45
UCEC	chr1	55107347	Missense_Mutation	NA	R1552C	0.05
UCEC	chr1	55134348	Silent	novel	L1089L	0.23
UCEC	chr1	55146031	Missense_Mutation	NA	L777I	0.39
UCEC	chr1	55146991	Missense_Mutation	rs751444448	R730C	0.43
UCEC	chr1	55079657	Missense_Mutation	novel	P2361T	0.4
UCEC	chr1	55172504	Missense_Mutation	novel	A192V	0.6
UCS	chr1	55147725	Missense_Mutation	novel	R681Q	0.38
UCS	chr1	55158880	Nonsense_Mutation	novel	E409*	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.2239	0.00038973

Survival Analysis

Cancer	P-value	Q-value
THYM	0.023	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.0053	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
KIRP	0.037	Kaplan-Meier Survival Analysis
COAD	0.016	Kaplan-Meier Survival Analysis
PAAD	0.029	Kaplan-Meier Survival Analysis
CESC	0.039	Kaplan-Meier Survival Analysis
READ	0.015	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
UCEC	0.021	Kaplan-Meier Survival Analysis
GBM	0.021	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.00038	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000162402 (Gene tree)
Gene ID: 23358
Gene Symbol: USP24
Alias: KIAA1057
Full Name: ubiquitin specific peptidase 24
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 149,010 bases
Position: chr1:55,066,359-55,215,368
Accession: 12623
RBP type: non-canonical RBP
Summary: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000484447	USP24-205	614	-	ENSP00000489026	150 (aa)	-	A0A0U1RQI9
ENST00000294383	USP24-201	10549	XM_005270690	ENSP00000294383	2620 (aa)	XP_005270747	Q9UPU5
ENST00000512504	USP24-206	568	-	-	- (aa)	-	-
ENST00000472566	USP24-202	731	-	-	- (aa)	-	-
ENST00000480962	USP24-203	406	-	-	- (aa)	-	-
ENST00000482197	USP24-204	600	-	-	- (aa)	-	-
ENST00000634589	USP24-207	370	-	ENSP00000489531	34 (aa)	-	A0A0U1RRH2

Gene Model

Click here to download ENSG00000162402's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000162402	Cholesterol, LDL	3.069e-005	19060910
ENSG00000162402	Personality	5.319e-005	-
ENSG00000162402	Cholesterol	6E-73	25961943
ENSG00000162402	Paliperidone Palmitate	8E-6	27846195
ENSG00000162402	Schizophrenia	8E-6	27846195
ENSG00000162402	Bronchial Provocation Tests	5E-7	25514360
ENSG00000162402	Pulmonary Disease, Chronic Obstructive	5E-7	25514360
ENSG00000162402	Bronchial Provocation Tests	9E-8	25514360
ENSG00000162402	Pulmonary Disease, Chronic Obstructive	9E-8	25514360
ENSG00000162402	Lipoproteins	5E-56	27005778
ENSG00000162402	Metabolism	5E-56	27005778
ENSG00000162402	Lipids	2E-17	23726366

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000162402	rs113353280	1	55180186	A	Response to paliperidone in schizophrenia (positive Marder score)	27846195	[NR] unit decrease	5.8417	EFO_0000692\|EFO_0007925\|EFO_0007927
ENSG00000162402	rs191448950	1	55119171	A	Metabolite levels (lipoprotein measures)	27005778	[0.44-0.56] unit decrease	0.5	EFO_0004732\|EFO_0005664
ENSG00000162402	rs17111652	1	55124792	T	Airway responsiveness in chronic obstructive pulmonary disease	25514360	[NR] unit decrease	0.234	EFO_0006897\|EFO_0000341
ENSG00000162402	rs17111652	1	55124792	T	Airway responsiveness in chronic obstructive pulmonary disease	25514360	[NR] unit decrease	0.071	EFO_0006897\|EFO_0000341
ENSG00000162402	rs17111684	1	55159875	A	LDL cholesterol	23726366	[NR] unit decrease	9.01	EFO_0004529
ENSG00000162402	rs191448950	1	55119171	G	Blood protein levels	30072576	[0.85-1.29] unit increase	1.069	EFO_0007937
ENSG00000162402	rs191448950	1	55119171	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.394	EFO_0004611
ENSG00000162402	rs191448950	1	55119171	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.388	EFO_0004611
ENSG00000162402	rs287227	1	55190402	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.077	EFO_0004611
ENSG00000162402	rs287227	1	55190402	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.071	EFO_0004611
ENSG00000162402	rs191448950	1	55119171	G	Total cholesterol levels	29507422	unit increase	0.339	EFO_0004574
ENSG00000162402	rs191448950	1	55119171	G	Total cholesterol levels	29507422	unit increase	0.338	EFO_0004574
ENSG00000162402	rs287227	1	55190402	G	Total cholesterol levels	29507422	unit increase	0.072	EFO_0004574
ENSG00000162402	rs287227	1	55190402	G	Total cholesterol levels	29507422	unit increase	0.067	EFO_0004574

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162402's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000162402	USP24	100	97.748	ENSMUSG00000028514	Usp24	100	97.748	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004197	cysteine-type endopeptidase activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0016579	protein deubiquitination	21873635.	IBA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	TAS	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.