EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27456359Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.Tumour Biol2016 OctStarska K-
16652152Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.Oncogene2006 Sep 21Carragher NO-
28280729Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway.Biomed Res Int2017Li Pdoi: 10.1155/2017/2593674
23389291Regulation of proteolytic cleavage of retinoid X receptor-α by GSK-3β.Carcinogenesis2013 JunGao Wdoi: 10.1093/carcin/bgt043
18332219Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.J Cell Biol2008 Mar 10Cortesio CLdoi: 10.1083/jcb.200708048.
30106446Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinaseB/survivin signaling.Oncol Rep2018 OctZhang Gdoi: 10.3892/or.2018.6625
30448882Calpain system protein expression and activity in ovarian cancer.J Cancer Res Clin Oncol2019 FebZhang Sdoi: 10.1007/s00432-018-2794-2

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1223759467Missense_MutationnovelK505N0.38
ACCchr1223762242Missense_MutationNAL541F0.48
BLCAchr1223759236Intronrs7661449280.16
BLCAchr1223771843Silentrs374729587I646I0.06
BLCAchr1223745393Missense_Mutationrs759517694E172K0.37
BLCAchr1223752927Missense_MutationnovelS369F0.21
BLCAchr1223755542Missense_MutationnovelD400N0.3
BRCAchr1223749063Missense_MutationNAA252T0.33
BRCAchr1223752942Missense_MutationNAC374Y0.2
BRCAchr1223771908Missense_Mutationrs550161035R668Q0.42
BRCAchr1223772219Missense_MutationnovelI687V0.73
BRCAchr1223762221SilentnovelF534F0.07
BRCAchr1223747025Frame_Shift_DelNAG198Vfs*200.23
BRCAchr1223749036Splice_Regionnovel0.27
BRCAchr1223747000Missense_MutationNAI188M0.65
BRCAchr1223752883SilentNAK354K0.3
BRCAchr1223755536Missense_Mutationrs368366230E398K0.31
CESCchr1223712652Missense_MutationnovelI4M0.29
CESCchr1223712775SilentnovelL45L0.49
CESCchr1223759449Silentrs746936966I499I0.4
CESCchr1223747043Missense_MutationnovelG203S0.41
CESCchr1223764156Missense_MutationnovelE547K0.27
COADchr1223761588Missense_Mutationrs369320951D513N0.38
COADchr1223747049Missense_Mutationrs761570360E205K0.24
COADchr1223755495Missense_MutationnovelN384S0.31
COADchr1223752019Missense_MutationNAD308N0.24
COADchr1223747166Splice_Siters549405629X243_splice0.34
COADchr1223772188Missense_MutationnovelF676L0.04
COADchr1223749117Missense_MutationNAE270K0.38
COADchr1223769908Splice_SiteNAX608_splice0.56
COADchr1223752931Silentrs377763395T370T0.14
COADchr1223712836Missense_MutationnovelY66H0.1
COADchr1223759420Missense_Mutationrs748221029E490K0.15
COADchr1223747003SilentNAN189N0.26
COADchr1223771900Missense_MutationnovelC665W0.06
COADchr1223764158Missense_MutationnovelE547D0.07
COADchr1223745374SilentNAL165L0.19
COADchr1223747025Frame_Shift_DelNAG198Vfs*200.29
ESCAchr12237126395'UTRnovel0.29
ESCAchr1223770467Silentrs369952708D615D0.16
GBMchr12237749303'UTRnovel0.37
GBMchr1223762189Missense_MutationnovelD524N0.15
GBMchr1223771867Missense_MutationnovelQ654H0.08
HNSCchr1223755581Missense_MutationnovelQ413E0.11
HNSCchr1223770498Missense_MutationnovelE626K0.13
HNSCchr1223755581Missense_MutationnovelQ413E0.34
KIRCchr1223752801Missense_MutationNAS327C0.39
KIRCchr1223766428SilentNAL584L0.14
KIRPchr1223771895Missense_MutationNAR664G0.28
KIRPchr1223712785Missense_MutationNAP49T0.42
LAMLchr1223772238Missense_MutationnovelS693F0.07
LGGchr1223712724SilentNAL28L0.35
LGGchr1223759252Intronnovel0.21
LIHCchr12237749213'UTRnovel0.39
LUADchr1223752934Silentrs145344369A371A0.09
LUADchr1223747029Missense_Mutationrs770020884G198V0.16
LUADchr1223755626Missense_Mutationrs760805402T428A0.19
LUADchr1223762247Missense_MutationNAG543V0.21
LUADchr1223759305SilentnovelN451N0.1
LUADchr1223772205Missense_MutationNAE682G0.48
LUADchr1223752002Frame_Shift_DelnovelS303Lfs*20.23
LUSCchr1223755518Missense_MutationnovelE392Q0.1
LUSCchr1223759328Missense_MutationnovelR459M0.2
LUSCchr12237749543'UTRnovel0.17
LUSCchr1223770464Silentrs779179250I614I0.34
LUSCchr1223764208Splice_Siters748554233X564_splice0.66
LUSCchr1223745435Missense_MutationnovelA186T0.41
LUSCchr1223762242Missense_MutationNAL541F0.33
MESOchr1223752938Missense_MutationnovelG373R0.33
OVchr1223762198Nonsense_MutationnovelE527*0.04
OVchr1223761606Missense_MutationnovelN519Y0.04
OVchr1223745401In_Frame_InsnovelS174_E175insLRYRA0.04
OVchr1223771866Missense_MutationnovelQ654P0.03
OVchr1223752872Missense_Mutationrs149659079D351N0.26
PRADchr1223759227Intronnovel0.24
PRADchr1223755616Missense_MutationnovelE424D0.17
PRADchr1223774839SilentnovelL695L0.38
READchr1223747048Silentrs139316104F204F0.57
READchr1223744191Missense_MutationNAE133D0.16
READchr1223752946Missense_MutationNAR375S0.35
READchr1223747048Silentrs139316104F204F0.35
READchr1223759420Missense_Mutationrs748221029E490K0.43
READchr1223761588Missense_Mutationrs369320951D513N0.3
SKCMchr1223759231Intronnovel0.27
SKCMchr1223717804Missense_Mutationrs144316024R94C0.43
SKCMchr12237750133'UTRnovel0.33
SKCMchr1223755506SilentNAL388L0.36
SKCMchr1223717799Missense_MutationnovelA92V0.09
SKCMchr1223744130Missense_MutationNAS113F0.05
SKCMchr1223747148Missense_MutationNAL238F0.16
SKCMchr1223745396Missense_MutationnovelG173R0.11
SKCMchr1223745397Missense_MutationnovelG173E0.11
SKCMchr1223752828Missense_Mutationrs769605419S336F0.42
SKCMchr1223752829SilentNAS336S0.43
STADchr1223755569Missense_Mutationrs760400151V409M0.2
STADchr1223747025Frame_Shift_DelNAG198Vfs*200.11
STADchr1223766398Silentrs778542593I574I0.15
STADchr1223759364Missense_MutationNAV471A0.24
STADchr1223759250Intronnovel0.31
STADchr1223747004Missense_Mutationrs541384226G190R0.43
STADchr1223755622Missense_MutationNAM426I0.11
STADchr1223759323Silentrs150813013R457R0.43
STADchr1223747025Frame_Shift_DelNAG198Vfs*200.29
STADchr1223762210Frame_Shift_DelnovelD531Mfs*260.33
STADchr1223759375Missense_MutationNAF475L0.27
STADchr1223770464SilentNAI614I0.09
STADchr1223745414Missense_Mutationrs763583591A179T0.19
THCAchr12237749663'UTRnovel0.17
UCECchr1223770504Missense_Mutationrs768014183R628W0.36
UCECchr1223747048Silentrs139316104F204F0.42
UCECchr1223762197Silentrs775930824S526S0.09
UCECchr1223770467Silentrs369952708D615D0.4
UCECchr12237754353'UTRnovel0.62
UCECchr1223759373Missense_Mutationrs776355445R474H0.28
UCECchr12237750623'UTRrs3694159390.49
UCECchr12237757543'UTRnovel0.3
UCECchr1223755590Nonsense_Mutationrs558508236R416*0.47
UCECchr12237751873'UTRnovel0.27
UCECchr12237751883'UTRnovel0.3
UCECchr1223747067Missense_MutationnovelI211V0.43
UCECchr1223717805Missense_Mutationrs768082890R94H0.15
UCECchr1223770466Missense_MutationNAD615G0.39
UCECchr1223771837SilentnovelQ644Q0.08
UCECchr1223749053SilentnovelA248A0.28
UCECchr1223771893Missense_MutationnovelV663G0.04
UCECchr1223750930Missense_Mutationrs755706736R285Q0.48
UCECchr1223747048Silentrs139316104F204F0.48
UCECchr1223761587SilentnovelV512V0.11
UCECchr1223712711Missense_MutationnovelA24V0.31
UCECchr1223712809Missense_Mutationrs146572729A57T0.26
UCECchr1223755514Missense_MutationnovelK390N0.16
UCECchr12237751883'UTRnovel0.41
UCECchr1223745375Missense_MutationnovelL166F0.33
UCECchr1223717771Missense_Mutationrs146935874A83T0.4
UCECchr1223752935Missense_Mutationrs199728877G372R0.24
UCECchr1223752920Missense_Mutationrs781468603R367W0.52
UCECchr1223750937SilentNAP287P0.34
UCECchr1223755593Missense_Mutationrs761658788R417W0.41
UCECchr12237756933'UTRnovel0.55
UCECchr1223750930Missense_MutationnovelR285L0.42
UCECchr1223766372Missense_MutationnovelD566Y0.23
UCECchr1223770510Missense_MutationnovelA630T0.14
UCECchr12237751023'UTRnovel0.17
UCECchr1223717805Missense_Mutationrs768082890R94H0.36
UCECchr1223759386Silentrs764806664P478P0.64
UCECchr12237751783'UTRnovel0.45
UCECchr12237757733'UTRnovel0.33
UCECchr1223769842Missense_Mutationrs533912773S586L0.38
UCECchr1223712761Missense_MutationnovelE41K0.26
UCECchr12237755063'UTRnovel0.36
UCECchr1223750957Missense_MutationnovelT294I0.24
UCECchr1223745375Missense_MutationNAL166I0.2
UCECchr1223747166Splice_Siters549405629X243_splice0.17
UCECchr1223752920Missense_Mutationrs781468603R367W0.19
UCECchr1223744160Missense_Mutationrs369599821R123Q0.11
UCECchr12237751783'UTRnovel0.43
UCECchr1223751994Splice_Regionnovel0.33
UCECchr1223759308Missense_MutationNAF452L0.48
UCECchr12237750553'UTRnovel0.38
UCECchr1223755535Silentrs201268064D397D0.59
UCECchr1223762217Missense_MutationnovelG533E0.46
UCECchr1223770504Missense_Mutationrs768014183R628W0.53
UCECchr12237750313'UTRnovel0.13
UCECchr12237758503'UTRnovel0.21
UCECchr1223752050Missense_Mutationrs764993899R318Q0.18
UCECchr1223752871SilentNAS350S0.14
UCECchr1223749062Missense_MutationnovelE251D0.4
UCECchr1223761587SilentnovelV512V0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.08330.033566
DLBCDEL0.1250.0017831
GBMDEL0.05720.00056261
KIRCDEL0.06630.018371
LGGDEL0.03510.11599
PCPGDEL0.07410.12617
READAMP0.26670.14328
SARCDEL0.29572.6086e-08
TGCTDEL0.03330.16985
THYMAMP0.17890.24554
UCECAMP0.37292.3921e-06

Survival Analysis
CancerP-value Q-value
KIRC0.023

Kaplan-Meier Survival Analysis

ACC0.032

Kaplan-Meier Survival Analysis

LUSC0.02

Kaplan-Meier Survival Analysis

ESCA0.03

Kaplan-Meier Survival Analysis

PAAD0.00013

Kaplan-Meier Survival Analysis

BLCA0.0012

Kaplan-Meier Survival Analysis

CESC0.0049

Kaplan-Meier Survival Analysis

LAML0.042

Kaplan-Meier Survival Analysis

GBM0.046

Kaplan-Meier Survival Analysis

LGG0.0081

Kaplan-Meier Survival Analysis

UVM0.02

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000162909 (Gene tree)
Gene ID
824
Gene Symbol
CAPN2
Alias
mCANP|CANPml|CANPL2
Full Name
calpain 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
74,426 bases
Position
chr1:223,701,593-223,776,018
Accession
1479
RBP type
non-canonical RBP
Summary
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15979041Structural analysis of inhibition mechanisms of aurintricarboxylic acid on SARS-CoV polymerase and other proteins.Comput Biol Chem2005 JunYap Y-
22711986Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.Mol Cell Biol2012 AugWang CFdoi: 10.1128/MCB.00296-12
29982852MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.Acta Neuropathol2018 OctEl Fatimy Rdoi: 10.1007/s00401-018-1880-5
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000487223CAPN2-2092991--- (aa)--
ENST00000434648CAPN2-203577-ENSP00000399949131 (aa)-C9JWY7
ENST00000498027CAPN2-2121405--- (aa)--
ENST00000295006CAPN2-2013573-ENSP00000295006700 (aa)-P17655
ENST00000483579CAPN2-208496--- (aa)--
ENST00000474026CAPN2-2064130--- (aa)--
ENST00000463997CAPN2-2042547--- (aa)--
ENST00000480581CAPN2-207513--- (aa)--
ENST00000433674CAPN2-2023264-ENSP00000413158622 (aa)-P17655
ENST00000492664CAPN2-211590--- (aa)--
ENST00000492565CAPN2-210331--- (aa)--
ENST00000472601CAPN2-205625--- (aa)--
Gene Model
Click here to download ENSG00000162909's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
hsa04210ApoptosisKEGG
hsa04217NecroptosisKEGG
hsa04218Cellular senescenceKEGG
hsa04510Focal adhesionKEGG
hsa05010Alzheimer diseaseKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000162909Seizures, Febrile6E-625344690
ENSG00000162909Schizophrenia8E-626198764
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000162909rs3732142841223712893TBlood protein levels29875488[0.93-1.51] unit decrease1.22EFO_0007937
ENSG00000162909rs1400847871223732743CFebrile seizures (MMR vaccine-related)25344690[1.95-5.41]3.25EFO_0006519
ENSG00000162909rs75396241223719125ASchizophrenia26198764[NR]1.06EFO_0000692
ENSG00000162909rs120382991223772690GBlood protein levels30072576[0.085-0.191] unit increase0.138EFO_0007937
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000162909's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000785chromatin-IEAComponent
GO:0001666response to hypoxia-IEAProcess
GO:0001824blastocyst development-IEAProcess
GO:0004198calcium-dependent cysteine-type endopeptidase activity21873635.IBAFunction
GO:0004198calcium-dependent cysteine-type endopeptidase activity12150984.IDAFunction
GO:0004198calcium-dependent cysteine-type endopeptidase activity-ISSFunction
GO:0005509calcium ion binding-IEAFunction
GO:0005515protein binding10639123.18519038.24705354.IPIFunction
GO:0005634nucleus-IEAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm-ISSComponent
GO:0005758mitochondrial intermembrane space-IEAComponent
GO:0005764lysosome-IEAComponent
GO:0005783endoplasmic reticulum14559243.IDAComponent
GO:0005794Golgi apparatus14559243.IDAComponent
GO:0005829cytosol12150984.14559243.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane12150984.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006508proteolysis21873635.IBAProcess
GO:0006508proteolysis-ISSProcess
GO:0007520myoblast fusion-IEAProcess
GO:0007565female pregnancy-IEAProcess
GO:0008092cytoskeletal protein binding12150984.NASFunction
GO:0008234cysteine-type peptidase activity2209092.TASFunction
GO:0009897external side of plasma membrane-IEAComponent
GO:0010666positive regulation of cardiac muscle cell apoptotic process-IEAProcess
GO:0016540protein autoprocessing-IEAProcess
GO:0019899enzyme binding-IEAFunction
GO:0022617extracellular matrix disassembly-TASProcess
GO:0030425dendrite-ISSComponent
GO:0030864cortical actin cytoskeleton12150984.TASComponent
GO:0031143pseudopodium14559243.IDAComponent
GO:0032675regulation of interleukin-6 production-IEAProcess
GO:0035458cellular response to interferon-beta-IEAProcess
GO:0042542response to hydrogen peroxide-IEAProcess
GO:0043025neuronal cell body-IEAComponent
GO:0045121membrane raft14559243.IDAComponent
GO:0045121membrane raft12150984.IDAComponent
GO:0046982protein heterodimerization activity-IEAFunction
GO:0048266behavioral response to pain-IEAProcess
GO:0051493regulation of cytoskeleton organization12150984.TASProcess
GO:0051603proteolysis involved in cellular protein catabolic process12150984.IDAProcess
GO:0070062extracellular exosome19056867.19199708.HDAComponent
GO:0071222cellular response to lipopolysaccharide-IEAProcess
GO:0071230cellular response to amino acid stimulus-ISSProcess
GO:0097038perinuclear endoplasmic reticulum14559243.IDAComponent
GO:1901216positive regulation of neuron death-IEAProcess
GO:1901741positive regulation of myoblast fusion-IEAProcess
GO:2001247positive regulation of phosphatidylcholine biosynthetic process-IEAProcess
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