EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27232533	SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.	Expert Opin Ther Targets	2016 Sep	Al Kubaisy E	doi: 10.1080/14728222.2016.1195059
27239795	Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.	Nat Struct Mol Biol	2016 Jul	Densham RM	doi: 10.1038/nsmb.3236
30308496	SMARCAD1 in Breast Cancer Progression.	Cell Physiol Biochem	2018	Arafat K	doi: 10.1159/000494163

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr4	94281558	Silent	novel	L898L	0.3
BLCA	chr4	94208515	Missense_Mutation	NA	E41K	0.07
BLCA	chr4	94252807	Missense_Mutation	novel	D361H	0.59
BLCA	chr4	94289697	3'UTR	novel		0.54
BLCA	chr4	94278920	Intron	novel		0.23
BLCA	chr4	94276338	Splice_Site	novel	X603_splice	0.38
BLCA	chr4	94280771	Silent	NA	L866L	0.13
BLCA	chr4	94249660	Nonsense_Mutation	NA	E238*	0.15
BLCA	chr4	94226264	Frame_Shift_Ins	novel	*K113Nfs17**	0.04
BLCA	chr4	94264812	Missense_Mutation	NA	E463K	0.26
BLCA	chr4	94270747	Missense_Mutation	novel	Q501E	0.33	ResIII
BLCA	chr4	94278957	Missense_Mutation	novel	M775I	0.09
BLCA	chr4	94252981	Missense_Mutation	NA	R419W	0.04
BLCA	chr4	94226262	Missense_Mutation	novel	E112Q	0.04
BLCA	chr4	94264759	Missense_Mutation	novel	C445Y	0.22
BRCA	chr4	94252791	Silent	NA	V355V	0.35
BRCA	chr4	94249655	Missense_Mutation	novel	G236E	0.12
BRCA	chr4	94285035	Silent	NA	L995L	0.11
BRCA	chr4	94277067	Silent	novel	L664L	0.08
BRCA	chr4	94240912	Missense_Mutation	NA	G204A	0.25
CESC	chr4	94252858	Missense_Mutation	NA	E378K	0.22
CESC	chr4	94278639	Missense_Mutation	novel	K734N	0.22
CESC	chr4	94276370	Missense_Mutation	novel	R614C	0.6	ResIII
CESC	chr4	94283227	Missense_Mutation	novel	I945L	0.07
CESC	chr4	94233958	Missense_Mutation	NA	E125K	0.1
CESC	chr4	94208413	Missense_Mutation	NA	D7Y	0.32
CESC	chr4	94273616	Splice_Site	novel	X525_splice	0.69
CESC	chr4	94226133	Missense_Mutation	rs555203609	P69A	0.27
CESC	chr4	94290423	3'UTR	novel		0.36
CESC	chr4	94290674	3'UTR	novel		0.45
CESC	chr4	94278619	Missense_Mutation	NA	L728V	0.21
COAD	chr4	94278697	Missense_Mutation	NA	L754I	0.39
COAD	chr4	94280781	Splice_Site	novel	X869_splice	0.24
COAD	chr4	94278722	Missense_Mutation	novel	I762N	0.17
COAD	chr4	94234105	Missense_Mutation	novel	D174Y	0.07
COAD	chr4	94278512	Nonsense_Mutation	novel	E725*	0.35
COAD	chr4	94278492	Missense_Mutation	novel	F718S	0.36
COAD	chr4	94249737	Silent	novel	F263F	0.09
COAD	chr4	94252889	Missense_Mutation	NA	K388T	0.29
COAD	chr4	94289638	3'UTR	novel		0.21
COAD	chr4	94289613	3'UTR	novel		0.06
COAD	chr4	94208476	Missense_Mutation	novel	S28A	0.11
COAD	chr4	94252772	Missense_Mutation	novel	F349S	0.45
COAD	chr4	94278929	Frame_Shift_Del	novel	*N768Tfs8**	0.45
COAD	chr4	94290161	3'UTR	novel		0.75
COAD	chr4	94276409	Missense_Mutation	novel	F627L	0.06	ResIII
COAD	chr4	94240985	Frame_Shift_Del	novel	*K230Rfs28**	0.26
COAD	chr4	94289779	3'UTR	novel		0.42
COAD	chr4	94278630	Frame_Shift_Ins	NA	*K734Qfs6**	0.31
COAD	chr4	94249656	Splice_Region	novel	G236G	0.08
COAD	chr4	94270793	Missense_Mutation	novel	L516H	0.03	ResIII
COAD	chr4	94249682	Missense_Mutation	rs3103117	S245Y	0.12
COAD	chr4	94252690	Missense_Mutation	NA	N322H	0.1
COAD	chr4	94279033	Missense_Mutation	novel	S801P	0.07
COAD	chr4	94278697	Missense_Mutation	NA	L754I	0.23
COAD	chr4	94289567	3'UTR	novel		0.36
COAD	chr4	94208422	Missense_Mutation	rs752567514	R10C	0.19
COAD	chr4	94278998	Missense_Mutation	NA	R789L	0.27
COAD	chr4	94278614	Splice_Site	novel	X727_splice	0.31
ESCA	chr4	94278434	Missense_Mutation	novel	E699Q	0.19
ESCA	chr4	94278953	Missense_Mutation	rs112326108	V774A	0.11
ESCA	chr4	94252759	Frame_Shift_Del	rs754697669	*N347Mfs24**	0.45
ESCA	chr4	94290546	3'UTR	novel		0.83
GBM	chr4	94249738	Missense_Mutation	novel	P264S	0.07
GBM	chr4	94278731	Missense_Mutation	novel	L765S	0.11
GBM	chr4	94280657	Silent	rs755185457	F828F	0.22
GBM	chr4	94208581	Missense_Mutation	novel	T63S	0.12
HNSC	chr4	94276403	Missense_Mutation	novel	A625P	0.2	ResIII
HNSC	chr4	94234080	Missense_Mutation	novel	L165F	0.3
HNSC	chr4	94234076	Missense_Mutation	novel	T164I	0.38
HNSC	chr4	94252998	Missense_Mutation	novel	W424C	0.78
HNSC	chr4	94284963	Missense_Mutation	novel	E971D	0.13
HNSC	chr4	94278970	Frame_Shift_Del	novel	*M781Wfs25**	0.2
KIRC	chr4	94273718	Splice_Site	novel	X558_splice	0.3
KIRP	chr4	94270784	Missense_Mutation	NA	K513R	0.38	ResIII
LGG	chr4	94226245	Missense_Mutation	novel	C106Y	0.35
LGG	chr4	94252727	Missense_Mutation	novel	M334T	0.26
LGG	chr4	94264782	Missense_Mutation	novel	D453N	0.45
LGG	chr4	94289481	Missense_Mutation	novel	G1010W	0.06
LGG	chr4	94226144	Silent	novel	P72P	0.36
LIHC	chr4	94277140	Missense_Mutation	NA	R688I	0.21
LIHC	chr4	94252780	Missense_Mutation	rs145303992	K352E	0.45
LUAD	chr4	94240971	Missense_Mutation	novel	D224H	0.14
LUAD	chr4	94250811	Silent	novel	L289L	0.18
LUAD	chr4	94236954	Missense_Mutation	NA	L180F	0.09
LUAD	chr4	94284959	Splice_Site	NA	X970_splice	0.29
LUAD	chr4	94252982	Missense_Mutation	novel	R419Q	0.33
LUAD	chr4	94277104	Missense_Mutation	NA	P676L	0.26
LUAD	chr4	94284986	Missense_Mutation	NA	S979I	0.21
LUAD	chr4	94233971	Missense_Mutation	novel	D129V	0.18
LUAD	chr4	94274781	Missense_Mutation	NA	K572N	0.27	ResIII
LUAD	chr4	94289473	Missense_Mutation	NA	G1007V	0.27
LUAD	chr4	94277058	Nonsense_Mutation	novel	Q661*	0.22
LUAD	chr4	94208413	Missense_Mutation	NA	D7Y	0.22
LUAD	chr4	94273620	Missense_Mutation	NA	L526V	0.23	ResIII
LUAD	chr4	94278993	Silent	novel	L787L	0.13
LUAD	chr4	94276351	Silent	NA	A607A	0.18
LUSC	chr4	94283237	Missense_Mutation	NA	D948V	0.36
LUSC	chr4	94252758	Frame_Shift_Ins	NA	*N347Kfs4**	0.48
LUSC	chr4	94278938	Missense_Mutation	NA	T769R	0.17
LUSC	chr4	94240966	Missense_Mutation	NA	F222Y	0.47
LUSC	chr4	94280749	Missense_Mutation	novel	L859S	0.19
LUSC	chr4	94252819	Missense_Mutation	novel	D365H	0.08
LUSC	chr4	94264748	Missense_Mutation	novel	L441F	0.37
LUSC	chr4	94208442	Silent	novel	K16K	0.08
LUSC	chr4	94226288	Silent	novel	V120V	0.32
LUSC	chr4	94278970	Missense_Mutation	novel	K780E	0.23
OV	chr4	94249750	Nonsense_Mutation	novel	K268*	0.1
OV	chr4	94285064	Missense_Mutation	novel	D1005V	0.06
OV	chr4	94234103	Missense_Mutation	NA	S173N	0.51
PAAD	chr4	94252978	Missense_Mutation	novel	L418F	0.19
PAAD	chr4	94283283	Nonsense_Mutation	novel	C963*	0.13
PRAD	chr4	94278928	Frame_Shift_Ins	rs750056186	*N768Kfs28**	0.38
PRAD	chr4	94264836	Frame_Shift_Ins	novel	*K471Ifs20**	0.09
PRAD	chr4	94264887	Missense_Mutation	novel	P488S	0.08
READ	chr4	94252688	Missense_Mutation	NA	K321T	0.34
READ	chr4	94280694	Missense_Mutation	NA	N841H	0.35
READ	chr4	94252758	Frame_Shift_Ins	NA	*N347Kfs4**	0.35
READ	chr4	94208534	Missense_Mutation	novel	G47V	0.1
READ	chr4	94284999	Silent	NA	I983I	0.08
READ	chr4	94283236	Missense_Mutation	novel	D948Y	0.38
READ	chr4	94280658	Missense_Mutation	NA	E829K	0.24
SARC	chr4	94273640	Silent	novel	A532A	0.33
SARC	chr4	94207680	5'Flank	novel		0.18
SKCM	chr4	94208352	5'UTR	novel		0.34
SKCM	chr4	94226231	Silent	rs757704006	V101V	0.36
SKCM	chr4	94252903	Missense_Mutation	NA	L393F	0.13
SKCM	chr4	94273650	Silent	NA	L536L	0.35
SKCM	chr4	94234040	Missense_Mutation	novel	S152L	0.15
SKCM	chr4	94226177	Silent	NA	F83F	0.21
SKCM	chr4	94277067	Silent	novel	L664L	0.17
SKCM	chr4	94280657	Silent	rs755185457	F828F	0.34
SKCM	chr4	94280686	Missense_Mutation	rs200626666	R838Q	0.08
SKCM	chr4	94273620	Silent	NA	L526L	0.38
SKCM	chr4	94226236	Missense_Mutation	NA	S103F	0.43
SKCM	chr4	94283284	Missense_Mutation	NA	H964Y	0.19
SKCM	chr4	94240942	Missense_Mutation	NA	S214L	0.1
SKCM	chr4	94276376	Silent	NA	L616L	0.09
SKCM	chr4	94289655	3'UTR	novel		0.35
SKCM	chr4	94285008	Silent	NA	S986S	0.17
STAD	chr4	94278614	Splice_Site	novel	X727_splice	0.14
STAD	chr4	94278668	Missense_Mutation	NA	S744L	0.18
STAD	chr4	94270813	Nonsense_Mutation	NA	E523*	0.28	ResIII
STAD	chr4	94252759	Frame_Shift_Del	rs754697669	*N347Mfs24**	0.58
STAD	chr4	94273672	Missense_Mutation	novel	G543D	0.13	ResIII
STAD	chr4	94208530	Missense_Mutation	novel	E46Q	0.33
STAD	chr4	94240975	Missense_Mutation	NA	D225V	0.1
STAD	chr4	94264819	Missense_Mutation	NA	I465N	0.1
STAD	chr4	94280688	Missense_Mutation	novel	H839Y	0.27
STAD	chr4	94208453	Missense_Mutation	rs749813218	A20V	0.12
STAD	chr4	94252758	Frame_Shift_Ins	NA	*N347Kfs4**	0.23
STAD	chr4	94277040	Missense_Mutation	NA	L655F	0.22	ResIII
STAD	chr4	94277043	Missense_Mutation	novel	T656P	0.06	ResIII
THCA	chr4	94283287	Nonsense_Mutation	novel	*R965Ifs8**	0.11
THYM	chr4	94278928	Frame_Shift_Ins	rs750056186	*N768Kfs28**	0.19
UCEC	chr4	94279002	Silent	rs746290982	Q790Q	0.92
UCEC	chr4	94289820	3'UTR	novel		0.1
UCEC	chr4	94252758	Frame_Shift_Ins	NA	*N347Kfs4**	0.23
UCEC	chr4	94237005	Missense_Mutation	novel	M197I	0.36
UCEC	chr4	94273650	Missense_Mutation	NA	L536M	0.3	ResIII
UCEC	chr4	94280742	Nonsense_Mutation	NA	R857*	0.26
UCEC	chr4	94208402	Missense_Mutation	novel	L3H	0.29
UCEC	chr4	94250754	Splice_Region	novel	E270E	0.43
UCEC	chr4	94278997	Missense_Mutation	NA	R789C	0.12
UCEC	chr4	94252927	Missense_Mutation	NA	L401F	0.36
UCEC	chr4	94278656	Missense_Mutation	NA	L740S	0.44
UCEC	chr4	94207676	5'Flank	novel		0.21
UCEC	chr4	94207992	5'Flank	novel		0.38
UCEC	chr4	94274785	Missense_Mutation	novel	L574I	0.38	ResIII
UCEC	chr4	94226292	Missense_Mutation	NA	I122V	0.53
UCEC	chr4	94283160	Silent	novel	I922I	0.25
UCEC	chr4	94278719	Missense_Mutation	novel	S761Y	0.35
UCEC	chr4	94289741	3'UTR	novel		0.44
UCEC	chr4	94289956	3'UTR	novel		0.39
UCEC	chr4	94226184	Missense_Mutation	novel	Q86K	0.14
UCEC	chr4	94279040	Missense_Mutation	novel	L803R	0.45
UCEC	chr4	94208575	Frame_Shift_Ins	novel	*T63Nfs5**	0.44
UCEC	chr4	94240914	Missense_Mutation	NA	P205S	0.17
UCEC	chr4	94252913	Missense_Mutation	NA	A396D	0.26
UCEC	chr4	94252758	Frame_Shift_Ins	NA	*N347Kfs4**	0.27
UCEC	chr4	94285020	Missense_Mutation	novel	I990M	0.16
UCEC	chr4	94289934	3'UTR	novel		0.24
UCEC	chr4	94252759	Frame_Shift_Del	rs754697669	*N347Mfs24**	0.46
UCEC	chr4	94278668	Missense_Mutation	NA	S744L	0.39
UCEC	chr4	94290522	3'UTR	novel		0.5
UCEC	chr4	94252671	Silent	novel	R315R	0.5
UCEC	chr4	94281503	Missense_Mutation	novel	T880N	0.33
UCEC	chr4	94252759	Frame_Shift_Del	rs754697669	*N347Mfs24**	0.34
UCEC	chr4	94280634	Missense_Mutation	NA	D821H	0.12
UCEC	chr4	94208108	Intron	novel		0.27
UCEC	chr4	94290742	3'UTR	novel		0.4
UCEC	chr4	94290315	3'UTR	novel		0.47
UCEC	chr4	94290826	3'UTR	novel		0.4
UCEC	chr4	94252758	Frame_Shift_Ins	NA	*N347Kfs4**	0.51
UCEC	chr4	94289685	3'UTR	novel		0.24
UCEC	chr4	94291154	3'UTR	novel		0.5
UCEC	chr4	94290708	3'UTR	novel		0.26
UCEC	chr4	94207687	5'Flank	novel		0.21
UCEC	chr4	94283160	Silent	novel	I922I	0.29
UCEC	chr4	94289638	3'UTR	novel		0.06
UCEC	chr4	94280611	Missense_Mutation	novel	A813V	0.38
UCEC	chr4	94290625	3'UTR	novel		0.2
UCEC	chr4	94208401	Missense_Mutation	novel	L3I	0.2
UCEC	chr4	94208563	Missense_Mutation	novel	S57P	0.17
UCEC	chr4	94289697	3'UTR	novel		0.1
UCEC	chr4	94290315	3'UTR	novel		0.18
UCEC	chr4	94290674	3'UTR	novel		0.17
UCEC	chr4	94278929	Frame_Shift_Del	novel	*N768Tfs8**	0.22
UCEC	chr4	94250807	Missense_Mutation	novel	S288Y	0.34
UCEC	chr4	94277152	Missense_Mutation	novel	S692Y	0.4
UCEC	chr4	94280742	Nonsense_Mutation	NA	R857*	0.05
UCEC	chr4	94208424	Silent	novel	R10R	0.33
UCEC	chr4	94240915	Missense_Mutation	novel	P205H	0.46
UCEC	chr4	94264848	Missense_Mutation	rs765506477	M475V	0.32
UCEC	chr4	94289873	3'UTR	rs775519810		0.22
UCEC	chr4	94276397	Missense_Mutation	novel	N623D	0.08	ResIII
UCEC	chr4	94289713	3'UTR	rs145778087		0.4
UCEC	chr4	94290212	3'UTR	novel		0.3
UCEC	chr4	94264906	Missense_Mutation	novel	S494I	0.56
UCEC	chr4	94252824	Silent	rs367710018	V366V	0.3
UCEC	chr4	94278997	Missense_Mutation	NA	R789C	0.24
UCEC	chr4	94278646	Nonsense_Mutation	NA	R737*	0.31
UCEC	chr4	94289697	3'UTR	novel		0.21
UCEC	chr4	94278630	Frame_Shift_Ins	NA	*K734Qfs6**	0.4
UCEC	chr4	94208349	5'UTR	novel		0.21
UCEC	chr4	94250767	Missense_Mutation	novel	L275F	0.48
UCEC	chr4	94226125	Missense_Mutation	rs11723410	S66F	0.49
UCEC	chr4	94278615	Splice_Site	novel	X727_splice	0.11
UCEC	chr4	94226246	Nonsense_Mutation	NA	C106*	0.22
UCEC	chr4	94277065	Missense_Mutation	NA	N663T	0.23
UCEC	chr4	94208005	5'Flank	novel		0.42
UCEC	chr4	94264709	Missense_Mutation	novel	F428L	0.44
UCEC	chr4	94278429	Missense_Mutation	novel	A697V	0.43
UCEC	chr4	94290206	3'UTR	novel		0.32
UCEC	chr4	94264732	Missense_Mutation	novel	G436D	0.3
UCEC	chr4	94252759	Frame_Shift_Del	rs754697669	*N347Mfs24**	0.37
UCS	chr4	94274893	Missense_Mutation	novel	S579Y	0.44	ResIII
UCS	chr4	94278978	Silent	novel	A782A	0.29
UCS	chr4	94280742	Nonsense_Mutation	NA	R857*	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.427	3.0903e-07
LUAD	DEL	0.1977	0.050802
MESO	DEL	0.4023	0.075661

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00014	Kaplan-Meier Survival Analysis
MESO	0.025	Kaplan-Meier Survival Analysis
HNSC	0.024	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PAAD	0.049	Kaplan-Meier Survival Analysis
BLCA	0.011	Kaplan-Meier Survival Analysis
READ	0.021	Kaplan-Meier Survival Analysis
LAML	0.0022	Kaplan-Meier Survival Analysis
GBM	0.032	Kaplan-Meier Survival Analysis
LIHC	0.0021	Kaplan-Meier Survival Analysis
UVM	0.045	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163104 (Gene tree)
Gene ID: 56916
Gene Symbol: SMARCAD1
Alias: ETL1|DKFZP762K2015|KIAA1122|DKFZp762K2015
Full Name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 83,685 bases
Position: chr4:94,207,608-94,291,292
Accession: 18398
RBP type: canonical RBP
Summary: This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000423286	ResIII	PF04851.15	5e-10	1	1
ENSP00000351947	ResIII	PF04851.15	7.8e-10	1	1
ENSP00000415576	ResIII	PF04851.15	7.8e-10	1	1
ENSP00000346217	ResIII	PF04851.15	7.8e-10	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000514232	SMARCAD1-208	444	-	-	- (aa)	-	-
ENST00000354268	SMARCAD1-201	4912	XM_017008463	ENSP00000346217	1026 (aa)	XP_016863952	Q9H4L7
ENST00000510105	SMARCAD1-207	2409	-	ENSP00000424624	244 (aa)	-	D6RAY8
ENST00000457823	SMARCAD1-204	4649	XM_024454154	ENSP00000415576	1028 (aa)	XP_024309922	Q9H4L7
ENST00000509418	SMARCAD1-206	2348	XM_017008464	ENSP00000423286	596 (aa)	XP_016863953	Q9H4L7
ENST00000359052	SMARCAD1-202	5017	-	ENSP00000351947	1028 (aa)	-	Q9H4L7
ENST00000394961	SMARCAD1-203	3778	-	ENSP00000378413	70 (aa)	-	F8W9M2
ENST00000506089	SMARCAD1-205	554	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000163104's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04550	Signaling pathways regulating pluripotency of stem cells	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163104	Schizophrenia	3.46E-5	-
ENSG00000163104	Schizophrenia	1.74E-5	-
ENSG00000163104	Schizophrenia	2.59E-5	-
ENSG00000163104	Schizophrenia	2.46E-5	-
ENSG00000163104	Schizophrenia	1.96E-5	-
ENSG00000163104	Waist-Hip Ratio	5.1600000E-006	-
ENSG00000163104	Cholesterol, LDL	7.1930000E-005	-
ENSG00000163104	Menarche	1E-10	25231870
ENSG00000163104	Antineoplastic Agents	7E-6	22864933
ENSG00000163104	Mental Disorders	4E-6	20889312

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163104	rs13135934	4	94286537	C	Menarche (age at onset)	25231870	[0.02-0.04] unit increase	0.03	EFO_0004703
ENSG00000163104	rs11097407	4	94224984	?	Bipolar disorder and schizophrenia	20889312	[NR]	1.2498	EFO_0000677
ENSG00000163104	rs3106136	4	94232198	?	Capecitabine sensitivity	22864933			GO_0097327
ENSG00000163104	rs10013456	4	94213541	A	Heel bone mineral density	28869591	[0.02-0.037] unit decrease	0.0283936	EFO_0009270
ENSG00000163104	rs10013456	4	94213541	A	Heel bone mineral density	28869591	[0.015-0.038] unit decrease	0.0269393	EFO_0009270
ENSG00000163104	rs10013456	4	94213541	?	Heel bone mineral density	30048462	[0.024-0.035] unit decrease	0.0292812	EFO_0009270
ENSG00000163104	rs34166467	4	94237499	?	Heel bone mineral density	30048462	[0.016-0.024] unit decrease	0.0198763	EFO_0009270
ENSG00000163104	rs28733161	4	94254718	?	Heel bone mineral density	30048462	[0.024-0.035] unit decrease	0.0298387	EFO_0009270
ENSG00000163104	rs10013456	4	94213541	A	Heel bone mineral density	30598549	[0.022-0.031] unit decrease	0.0263959	EFO_0009270
ENSG00000163104	rs10013456	4	94213541	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163104's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163104	SMARCAD1	99	67.340	ENSAPOG00000011446	smarcad1a	66	62.483	Acanthochromis_polyacanthus
ENSG00000163104	SMARCAD1	100	98.993	ENSAMEG00000005844	SMARCAD1	100	97.374	Ailuropoda_melanoleuca
ENSG00000163104	SMARCAD1	97	67.530	ENSACIG00000018326	smarcad1a	100	68.587	Amphilophus_citrinellus
ENSG00000163104	SMARCAD1	99	67.340	ENSAOCG00000019762	smarcad1a	96	62.748	Amphiprion_ocellaris
ENSG00000163104	SMARCAD1	99	67.508	ENSAPEG00000003889	smarcad1a	66	62.483	Amphiprion_percula
ENSG00000163104	SMARCAD1	97	68.631	ENSATEG00000015608	smarcad1a	90	62.570	Anabas_testudineus
ENSG00000163104	SMARCAD1	100	84.757	ENSAPLG00000004630	SMARCAD1	100	72.467	Anas_platyrhynchos
ENSG00000163104	SMARCAD1	100	83.417	ENSACAG00000013554	SMARCAD1	100	70.320	Anolis_carolinensis
ENSG00000163104	SMARCAD1	100	99.497	ENSANAG00000020488	SMARCAD1	100	99.222	Aotus_nancymaae
ENSG00000163104	SMARCAD1	100	67.114	ENSACLG00000017063	smarcad1a	99	61.308	Astatotilapia_calliptera
ENSG00000163104	SMARCAD1	100	67.953	ENSAMXG00000019130	smarcad1b	85	59.649	Astyanax_mexicanus
ENSG00000163104	SMARCAD1	100	65.436	ENSAMXG00000015470	smarcad1a	99	60.251	Astyanax_mexicanus
ENSG00000163104	SMARCAD1	100	97.993	ENSBTAG00000017061	SMARCAD1	100	96.696	Bos_taurus
ENSG00000163104	SMARCAD1	96	44.597	WBGene00010845	M03C11.8	70	40.647	Caenorhabditis_elegans
ENSG00000163104	SMARCAD1	100	99.832	ENSCJAG00000006778	SMARCAD1	100	99.318	Callithrix_jacchus
ENSG00000163104	SMARCAD1	100	98.658	ENSCAFG00000010026	SMARCAD1	100	96.887	Canis_familiaris
ENSG00000163104	SMARCAD1	100	98.658	ENSCAFG00020003994	SMARCAD1	99	97.860	Canis_lupus_dingo
ENSG00000163104	SMARCAD1	100	98.826	ENSCHIG00000012905	SMARCAD1	100	97.082	Capra_hircus
ENSG00000163104	SMARCAD1	100	98.826	ENSTSYG00000002706	SMARCAD1	100	97.760	Carlito_syrichta
ENSG00000163104	SMARCAD1	97	87.348	ENSCAPG00000016744	SMARCAD1	96	78.817	Cavia_aperea
ENSG00000163104	SMARCAD1	100	97.987	ENSCPOG00000011398	SMARCAD1	100	94.477	Cavia_porcellus
ENSG00000163104	SMARCAD1	100	99.664	ENSCCAG00000022264	SMARCAD1	100	99.664	Cebus_capucinus
ENSG00000163104	SMARCAD1	100	100.000	ENSCATG00000035663	SMARCAD1	100	99.663	Cercocebus_atys
ENSG00000163104	SMARCAD1	100	100.000	ENSCSAG00000004186	SMARCAD1	100	99.762	Chlorocebus_sabaeus
ENSG00000163104	SMARCAD1	100	85.427	ENSCPBG00000013203	SMARCAD1	100	74.256	Chrysemys_picta_bellii
ENSG00000163104	SMARCAD1	100	50.415	ENSCING00000001688	-	99	49.775	Ciona_intestinalis
ENSG00000163104	SMARCAD1	100	100.000	ENSCANG00000003556	SMARCAD1	100	100.000	Colobus_angolensis_palliatus
ENSG00000163104	SMARCAD1	100	97.315	ENSCGRG00001015056	Smarcad1	100	93.275	Cricetulus_griseus_chok1gshd
ENSG00000163104	SMARCAD1	100	97.315	ENSCGRG00000014087	Smarcad1	100	93.275	Cricetulus_griseus_crigri
ENSG00000163104	SMARCAD1	100	65.101	ENSCSEG00000014419	-	95	59.554	Cynoglossus_semilaevis
ENSG00000163104	SMARCAD1	100	65.772	ENSCSEG00000017903	smarcad1a	100	46.702	Cynoglossus_semilaevis
ENSG00000163104	SMARCAD1	99	65.825	ENSDARG00000014041	smarcad1a	92	55.678	Danio_rerio
ENSG00000163104	SMARCAD1	100	66.275	ENSDARG00000073721	smarcad1b	82	59.137	Danio_rerio
ENSG00000163104	SMARCAD1	100	97.987	ENSDNOG00000000806	-	100	96.394	Dasypus_novemcinctus
ENSG00000163104	SMARCAD1	100	97.819	ENSDORG00000012331	Smarcad1	100	93.100	Dipodomys_ordii
ENSG00000163104	SMARCAD1	99	46.566	FBgn0032157	Etl1	90	40.319	Drosophila_melanogaster
ENSG00000163104	SMARCAD1	95	48.342	ENSEBUG00000003969	smarcad1a	96	46.191	Eptatretus_burgeri
ENSG00000163104	SMARCAD1	100	98.826	ENSEASG00005012382	SMARCAD1	100	97.082	Equus_asinus_asinus
ENSG00000163104	SMARCAD1	100	98.826	ENSECAG00000011562	SMARCAD1	100	97.082	Equus_caballus
ENSG00000163104	SMARCAD1	99	67.172	ENSELUG00000018535	smarcad1a	100	51.344	Esox_lucius
ENSG00000163104	SMARCAD1	98	65.812	ENSELUG00000019154	smarcad1b	79	58.824	Esox_lucius
ENSG00000163104	SMARCAD1	100	98.993	ENSFCAG00000003958	SMARCAD1	100	98.993	Felis_catus
ENSG00000163104	SMARCAD1	100	84.087	ENSFALG00000006089	SMARCAD1	100	67.437	Ficedula_albicollis
ENSG00000163104	SMARCAD1	100	98.154	ENSFDAG00000017027	SMARCAD1	100	95.809	Fukomys_damarensis
ENSG00000163104	SMARCAD1	99	67.508	ENSFHEG00000012778	smarcad1a	100	62.483	Fundulus_heteroclitus
ENSG00000163104	SMARCAD1	100	66.332	ENSGMOG00000018995	smarcad1a	97	57.604	Gadus_morhua
ENSG00000163104	SMARCAD1	100	79.899	ENSGALG00000037339	SMARCAD1	94	74.713	Gallus_gallus
ENSG00000163104	SMARCAD1	99	66.835	ENSGAFG00000013498	smarcad1a	100	47.178	Gambusia_affinis
ENSG00000163104	SMARCAD1	99	66.891	ENSGACG00000007327	smarcad1a	99	58.050	Gasterosteus_aculeatus
ENSG00000163104	SMARCAD1	100	85.260	ENSGAGG00000008582	SMARCAD1	100	74.035	Gopherus_agassizii
ENSG00000163104	SMARCAD1	100	100.000	ENSGGOG00000023001	SMARCAD1	100	99.903	Gorilla_gorilla
ENSG00000163104	SMARCAD1	100	66.946	ENSHBUG00000011042	smarcad1a	99	61.172	Haplochromis_burtoni
ENSG00000163104	SMARCAD1	100	98.154	ENSHGLG00000005070	SMARCAD1	100	95.918	Heterocephalus_glaber_female
ENSG00000163104	SMARCAD1	100	98.154	ENSHGLG00100006812	SMARCAD1	100	95.918	Heterocephalus_glaber_male
ENSG00000163104	SMARCAD1	100	64.597	ENSHCOG00000007848	smarcad1a	98	59.306	Hippocampus_comes
ENSG00000163104	SMARCAD1	99	65.825	ENSIPUG00000000242	smarcad1a	60	65.825	Ictalurus_punctatus
ENSG00000163104	SMARCAD1	100	67.114	ENSIPUG00000022817	smarcad1b	89	57.279	Ictalurus_punctatus
ENSG00000163104	SMARCAD1	100	98.658	ENSSTOG00000001227	SMARCAD1	100	97.371	Ictidomys_tridecemlineatus
ENSG00000163104	SMARCAD1	100	98.322	ENSJJAG00000022342	Smarcad1	100	96.101	Jaculus_jaculus
ENSG00000163104	SMARCAD1	98	67.182	ENSKMAG00000021351	smarcad1a	65	61.615	Kryptolebias_marmoratus
ENSG00000163104	SMARCAD1	99	67.845	ENSLBEG00000008088	smarcad1a	63	65.821	Labrus_bergylta
ENSG00000163104	SMARCAD1	100	71.141	ENSLOCG00000012909	smarcad1a	100	55.245	Lepisosteus_oculatus
ENSG00000163104	SMARCAD1	100	95.638	ENSLAFG00000000040	SMARCAD1	100	94.542	Loxodonta_africana
ENSG00000163104	SMARCAD1	100	100.000	ENSMFAG00000042606	SMARCAD1	100	99.438	Macaca_fascicularis
ENSG00000163104	SMARCAD1	100	100.000	ENSMMUG00000022242	SMARCAD1	100	99.438	Macaca_mulatta
ENSG00000163104	SMARCAD1	100	99.832	ENSMNEG00000038117	SMARCAD1	100	99.832	Macaca_nemestrina
ENSG00000163104	SMARCAD1	100	100.000	ENSMLEG00000038333	SMARCAD1	100	100.000	Mandrillus_leucophaeus
ENSG00000163104	SMARCAD1	99	68.182	ENSMAMG00000000933	smarcad1a	94	63.561	Mastacembelus_armatus
ENSG00000163104	SMARCAD1	100	67.114	ENSMZEG00005005203	smarcad1a	100	49.817	Maylandia_zebra
ENSG00000163104	SMARCAD1	100	80.769	ENSMGAG00000005577	SMARCAD1	100	64.985	Meleagris_gallopavo
ENSG00000163104	SMARCAD1	100	97.483	ENSMAUG00000008417	Smarcad1	100	93.177	Mesocricetus_auratus
ENSG00000163104	SMARCAD1	100	98.829	ENSMICG00000009746	SMARCAD1	100	97.279	Microcebus_murinus
ENSG00000163104	SMARCAD1	100	97.148	ENSMOCG00000017142	Smarcad1	100	93.080	Microtus_ochrogaster
ENSG00000163104	SMARCAD1	100	67.114	ENSMMOG00000000275	smarcad1a	92	64.382	Mola_mola
ENSG00000163104	SMARCAD1	100	90.604	ENSMODG00000019268	SMARCAD1	100	81.660	Monodelphis_domestica
ENSG00000163104	SMARCAD1	100	96.477	MGP_CAROLIEiJ_G0028458	-	77	93.861	Mus_caroli
ENSG00000163104	SMARCAD1	100	96.477	ENSMUSG00000029920	Smarcad1	100	92.308	Mus_musculus
ENSG00000163104	SMARCAD1	100	96.644	MGP_PahariEiJ_G0022198	Smarcad1	100	92.405	Mus_pahari
ENSG00000163104	SMARCAD1	100	96.477	MGP_SPRETEiJ_G0029462	Smarcad1	100	92.308	Mus_spretus
ENSG00000163104	SMARCAD1	100	98.826	ENSMPUG00000002111	SMARCAD1	100	97.179	Mustela_putorius_furo
ENSG00000163104	SMARCAD1	100	96.823	ENSMLUG00000000425	SMARCAD1	100	93.482	Myotis_lucifugus
ENSG00000163104	SMARCAD1	100	97.987	ENSNGAG00000000810	Smarcad1	100	94.250	Nannospalax_galili
ENSG00000163104	SMARCAD1	97	67.358	ENSNBRG00000012749	smarcad1a	85	61.367	Neolamprologus_brichardi
ENSG00000163104	SMARCAD1	100	100.000	ENSNLEG00000014225	SMARCAD1	100	100.000	Nomascus_leucogenys
ENSG00000163104	SMARCAD1	100	97.987	ENSODEG00000004334	SMARCAD1	100	94.752	Octodon_degus
ENSG00000163104	SMARCAD1	100	66.611	ENSONIG00000015059	smarcad1a	100	52.220	Oreochromis_niloticus
ENSG00000163104	SMARCAD1	100	89.799	ENSOANG00000013764	SMARCAD1	100	85.024	Ornithorhynchus_anatinus
ENSG00000163104	SMARCAD1	100	98.490	ENSOCUG00000017283	SMARCAD1	100	97.076	Oryctolagus_cuniculus
ENSG00000163104	SMARCAD1	99	66.667	ENSORLG00000004869	smarcad1a	68	61.180	Oryzias_latipes
ENSG00000163104	SMARCAD1	99	66.667	ENSORLG00020020569	smarcad1a	68	60.989	Oryzias_latipes_hni
ENSG00000163104	SMARCAD1	99	66.498	ENSORLG00015009045	smarcad1a	69	61.454	Oryzias_latipes_hsok
ENSG00000163104	SMARCAD1	99	66.498	ENSOMEG00000023032	smarcad1a	69	61.149	Oryzias_melastigma
ENSG00000163104	SMARCAD1	100	97.492	ENSOGAG00000011444	SMARCAD1	100	96.793	Otolemur_garnettii
ENSG00000163104	SMARCAD1	100	98.826	ENSOARG00000017851	SMARCAD1	100	96.984	Ovis_aries
ENSG00000163104	SMARCAD1	100	100.000	ENSPPAG00000035715	SMARCAD1	100	99.805	Pan_paniscus
ENSG00000163104	SMARCAD1	100	98.993	ENSPPRG00000024756	SMARCAD1	100	98.993	Panthera_pardus
ENSG00000163104	SMARCAD1	100	98.662	ENSPTIG00000017868	SMARCAD1	100	96.987	Panthera_tigris_altaica
ENSG00000163104	SMARCAD1	100	100.000	ENSPTRG00000023126	SMARCAD1	100	100.000	Pan_troglodytes
ENSG00000163104	SMARCAD1	100	97.997	ENSPANG00000019757	SMARCAD1	100	97.959	Papio_anubis
ENSG00000163104	SMARCAD1	100	84.422	ENSPSIG00000010255	SMARCAD1	100	73.301	Pelodiscus_sinensis
ENSG00000163104	SMARCAD1	99	64.874	ENSPMGG00000010735	smarcad1a	95	62.722	Periophthalmus_magnuspinnatus
ENSG00000163104	SMARCAD1	90	96.825	ENSPEMG00000001854	Smarcad1	100	79.045	Peromyscus_maniculatus_bairdii
ENSG00000163104	SMARCAD1	99	59.701	ENSPMAG00000003516	smarcad1a	99	47.003	Petromyzon_marinus
ENSG00000163104	SMARCAD1	100	90.604	ENSPCIG00000008137	SMARCAD1	98	88.874	Phascolarctos_cinereus
ENSG00000163104	SMARCAD1	99	67.003	ENSPFOG00000019116	smarcad1a	64	62.430	Poecilia_formosa
ENSG00000163104	SMARCAD1	99	66.835	ENSPLAG00000000108	smarcad1a	64	62.291	Poecilia_latipinna
ENSG00000163104	SMARCAD1	99	67.003	ENSPMEG00000009155	smarcad1a	64	62.430	Poecilia_mexicana
ENSG00000163104	SMARCAD1	99	67.508	ENSPREG00000018185	smarcad1a	94	62.587	Poecilia_reticulata
ENSG00000163104	SMARCAD1	100	99.319	ENSPPYG00000014935	SMARCAD1	100	99.319	Pongo_abelii
ENSG00000163104	SMARCAD1	90	100.000	ENSPCOG00000020478	SMARCAD1	89	97.561	Propithecus_coquereli
ENSG00000163104	SMARCAD1	100	96.321	ENSPVAG00000001760	SMARCAD1	100	95.432	Pteropus_vampyrus
ENSG00000163104	SMARCAD1	97	67.128	ENSPNYG00000010087	smarcad1a	86	60.948	Pundamilia_nyererei
ENSG00000163104	SMARCAD1	100	68.121	ENSPNAG00000010099	smarcad1b	84	59.623	Pygocentrus_nattereri
ENSG00000163104	SMARCAD1	99	66.667	ENSPNAG00000001663	smarcad1a	100	49.489	Pygocentrus_nattereri
ENSG00000163104	SMARCAD1	100	96.812	ENSRNOG00000006391	Smarcad1	100	93.087	Rattus_norvegicus
ENSG00000163104	SMARCAD1	100	100.000	ENSRBIG00000041989	SMARCAD1	100	99.415	Rhinopithecus_bieti
ENSG00000163104	SMARCAD1	100	100.000	ENSRROG00000035309	SMARCAD1	100	99.415	Rhinopithecus_roxellana
ENSG00000163104	SMARCAD1	100	99.664	ENSSBOG00000032114	SMARCAD1	100	99.664	Saimiri_boliviensis_boliviensis
ENSG00000163104	SMARCAD1	100	91.107	ENSSHAG00000001279	SMARCAD1	100	82.529	Sarcophilus_harrisii
ENSG00000163104	SMARCAD1	99	68.013	ENSSFOG00015016814	smarcad1b	100	50.465	Scleropages_formosus
ENSG00000163104	SMARCAD1	99	64.706	ENSSFOG00015020909	smarcad1a	100	57.772	Scleropages_formosus
ENSG00000163104	SMARCAD1	99	68.182	ENSSMAG00000001326	smarcad1a	64	64.470	Scophthalmus_maximus
ENSG00000163104	SMARCAD1	99	67.340	ENSSDUG00000022338	smarcad1a	84	62.325	Seriola_dumerili
ENSG00000163104	SMARCAD1	99	67.003	ENSSLDG00000024986	smarcad1a	67	61.496	Seriola_lalandi_dorsalis
ENSG00000163104	SMARCAD1	100	84.590	ENSSPUG00000004633	SMARCAD1	100	84.590	Sphenodon_punctatus
ENSG00000163104	SMARCAD1	99	67.508	ENSSPAG00000001970	smarcad1a	96	62.430	Stegastes_partitus
ENSG00000163104	SMARCAD1	100	98.826	ENSSSCG00000009193	SMARCAD1	100	97.979	Sus_scrofa
ENSG00000163104	SMARCAD1	100	85.092	ENSTGUG00000003127	SMARCAD1	100	78.189	Taeniopygia_guttata
ENSG00000163104	SMARCAD1	99	68.067	ENSTNIG00000017585	smarcad1a	99	57.666	Tetraodon_nigroviridis
ENSG00000163104	SMARCAD1	91	98.214	ENSTBEG00000002789	SMARCAD1	91	98.214	Tupaia_belangeri
ENSG00000163104	SMARCAD1	100	98.660	ENSTTRG00000000226	SMARCAD1	100	95.933	Tursiops_truncatus
ENSG00000163104	SMARCAD1	100	99.161	ENSUAMG00000022262	SMARCAD1	100	97.276	Ursus_americanus
ENSG00000163104	SMARCAD1	100	99.161	ENSUMAG00000004549	SMARCAD1	100	97.566	Ursus_maritimus
ENSG00000163104	SMARCAD1	100	98.490	ENSVVUG00000007271	SMARCAD1	100	97.503	Vulpes_vulpes
ENSG00000163104	SMARCAD1	100	73.244	ENSXETG00000019214	smarcad1	100	65.529	Xenopus_tropicalis
ENSG00000163104	SMARCAD1	99	65.878	ENSXCOG00000005232	smarcad1a	88	57.584	Xiphophorus_couchianus
ENSG00000163104	SMARCAD1	99	66.667	ENSXMAG00000015350	smarcad1a	64	61.925	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000018	regulation of DNA recombination	11031099.	IEP	Process
GO:0000729	DNA double-strand break processing	22960744.	IMP	Process
GO:0000792	heterochromatin	-	ISS	Component
GO:0003676	nucleic acid binding	11031099.	NAS	Function
GO:0003677	DNA binding	18675275.	IDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	18675275.21549307.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006325	chromatin organization	11031099.	NAS	Process
GO:0006338	chromatin remodeling	21549307.	NAS	Process
GO:0009117	nucleotide metabolic process	11031099.	NAS	Process
GO:0016363	nuclear matrix	11031099.	NAS	Component
GO:0035861	site of double-strand break	22960744.	IDA	Component
GO:0043044	ATP-dependent chromatin remodeling	22960744.	IMP	Process
GO:0043596	nuclear replication fork	21549307.	IDA	Component
GO:0045893	positive regulation of transcription, DNA-templated	11031099.	NAS	Process
GO:0051260	protein homooligomerization	11031099.	NAS	Process
GO:0051304	chromosome separation	21549307.	IMP	Process
GO:0070932	histone H3 deacetylation	21549307.	IMP	Process
GO:0070933	histone H4 deacetylation	21549307.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.