EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29733516	Clinical significance of calcium-binding protein S100A8 and S100A9 expression in non-small cell lung cancer.	Thorac Cancer	2018 Jul	Huang H	doi: 10.1111/1759-7714.12649
26397389	Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9.	Oncol Rep	2015 Dec	Hsu YL	doi: 10.3892/or.2015.4307
26404752	A pro-tumorigenic function of S100A8/A9 in carcinogen-induced hepatocellular carcinoma.	Cancer Lett	2015 Dec 28	De Ponti A	doi: 10.1016/j.canlet.2015.09.005
28983059	Pro-inflammatory proteins S100A9 and tumor necrosis factor-α suppress erythropoietin elaboration in myelodysplastic syndromes.	Haematologica	2017 Dec	Cluzeau T	doi: 10.3324/haematol.2016.158857
15069705	Loss of myeloid-related proteins 8 and myeloid-related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiation.	World J Gastroenterol	2004 Apr 15	Kong JP	-
15075348	Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions.	J Leukoc Biol	2004 Jul	Ghavami S	-
21228116	S100A8/A9 activate key genes and pathways in colon tumor progression.	Mol Cancer Res	2011 Feb	Ichikawa M	doi: 10.1158/1541-7786.MCR-10-0394
18689872	RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.	Carcinogenesis	2008 Oct	Turovskaya O	doi: 10.1093/carcin/bgn188
17126494	On the mechanism of apoptosis-inducing activity of human calprotectin: zinc sequestration, induction of a signaling pathway, or something else?	Med Hypotheses	2007	Zali H	-
22864818	Roles of galectin-7 and S100A9 in cervical squamous carcinoma: Clinicopathological and in vitro evidence.	Int J Cancer	2013 Mar 1	Zhu H	doi: 10.1002/ijc.27764
22634002	The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment.	Biochem Biophys Res Commun	2012 Jun 22	Kim JH	doi: 10.1016/j.bbrc.2012.05.081
27086923	Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.	Oncogene	2016 Nov 3	Lim SY	doi: 10.1038/onc.2016.107
22838504	Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer.	BMC Cancer	2012 Jul 28	Fan B	doi: 10.1186/1471-2407-12-316.
22691358	[Expression and clinical significance of calcium-binding protein S100A9 in breast cancer].	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi	2012 Jun	Du XM	-
23248262	Increased myeloid-derived suppressor cells in gastric cancer correlate with cancer stage and plasma S100A8/A9 proinflammatory proteins.	J Immunol	2013 Jan 15	Wang L	doi: 10.4049/jimmunol.1202088
20819668	Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features.	Chin Med J (Engl)	2010 Aug	Su YJ	-
24122301	Impact of S100A8/A9 expression on prostate cancer progression in vitro and in vivo.	J Cell Physiol	2014 May	Grebhardt S	doi: 10.1002/jcp.24489.
22074005	Proteomic approach reveals FKBP4 and S100A9 as potential prediction markers of therapeutic response to neoadjuvant chemotherapy in patients with breast cancer.	J Proteome Res	2012 Feb 3	Yang WS	doi: 10.1021/pr2008187
24726733	High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome.	Eur J Cancer	2014 Jul	Tidehag V	doi: 10.1016/j.ejca.2014.03.278
22505354	Hypoxia and HIF-1 increase S100A8 and S100A9 expression in prostate cancer.	Int J Cancer	2012 Dec 15	Grebhardt S	doi: 10.1002/ijc.27591
24041228	Intracellular expression of inflammatory proteins S100A8 and S100A9 leads to epithelial-mesenchymal transition and attenuated aggressivity of breast cancer cells.	Anticancer Agents Med Chem	2014 Jan	Cormier K	-
23456298	S100A8 and S100A9 promotes invasion and migration through p38 mitogen-activated protein kinase-dependent NF-??B activation in gastric cancer cells.	Mol Cells	2013 Mar	Kwon CH	doi: 10.1007/s10059-013-2269-x
24948111	ID1 promotes breast cancer metastasis by S100A9 regulation.	Mol Cancer Res	2014 Sep	Gumireddy K	doi: 10.1158/1541-7786.MCR-14-0049
25236491	S100A8/A9 regulates MMP-2 expression and invasion and migration by carcinoma cells.	Int J Biochem Cell Biol	2014 Oct	Silva EJ	doi: 10.1016/j.biocel.2014.09.007
24177755	RAGE-binding S100A8/A9 promotes the migration and invasion of human breast cancer cells through actin polymerization and epithelial-mesenchymal transition.	Breast Cancer Res Treat	2013 Nov	Yin C	doi: 10.1007/s10549-013-2737-1
22622474	Elevated levels of proliferating and recently migrated tumor-associated macrophages confer increased aggressiveness and worse outcomes in breast cancer.	Ann Surg Oncol	2012 Nov	Mukhtar RA	doi: 10.1245/s10434-012-2415-2
25348783	Comparison of mRNA, Protein, and Urinary Nucleic Acid Levels of S100A8 and S100A9 between Prostate Cancer and BPH.	Ann Surg Oncol	2015 Jul	Yun SJ	doi: 10.1245/s10434-014-4194-4
21799753	The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC.	PLoS One	2011	Ohri CM	doi: 10.1371/journal.pone.0021874
21369941	Prognostic impact of S100A9 overexpression in non-small cell lung cancer.	Tumour Biol	2011 Aug	Kawai H	doi: 10.1007/s13277-011-0163-8
22304731	S100A9 a new marker for monocytic human myeloid-derived suppressor cells.	Immunology	2012 Jun	Zhao F	doi: 10.1111/j.1365-2567.2012.03566.x.
26653550	Diagnostic importance of S100A9 and S100A12 in breast cancer.	Biomed Pharmacother	2015 Dec	Gunaldi M	doi: 10.1016/j.biopha.2015.10.029
24631944	S100A9 and EGFR gene signatures predict disease progression in muscle invasive bladder cancer patients after chemotherapy.	Ann Oncol	2014 May	Kim WT	doi: 10.1093/annonc/mdu037
26713053	Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer.	J Korean Med Sci	2015 Dec	Yan C	doi: 10.3346/jkms.2015.30.12.1784
15040889	Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer.	Cell Res	2004 Feb	Wang J	-
23637971	S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway.	PLoS One	2013 Apr 26	Duan L	doi: 10.1371/journal.pone.0062092
26315114	Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production.	Oncotarget	2015 Sep 29	Fang WY	doi: 10.18632/oncotarget.4951.
27191989	Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis.	Oncotarget	2016 Jun 14	Li M	doi: 10.18632/oncotarget.9362.
28036279	Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116.	Oncotarget	2017 Jan 24	Myung JK	doi: 10.18632/oncotarget.14301.
28609200	Significance of S100A8, S100A9 and calprotectin levels in bladder cancer.	Scand J Clin Lab Invest	2017 Oct	Yasar O	doi: 10.1080/00365513.2017.1336567

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	153360965	3'UTR	novel		0.1
BLCA	chr1	153360704	Missense_Mutation	NA	D71N	0.41
BLCA	chr1	153360649	Silent	novel	E52E	0.25
BLCA	chr1	153358311	Missense_Mutation	rs140601192	R10C	0.25
CESC	chr1	153358312	Missense_Mutation	NA	R10P	0.49
COAD	chr1	153358408	Missense_Mutation	rs142015410	R42Q	0.3
COAD	chr1	153358300	Missense_Mutation	NA	S6L	0.31
HNSC	chr1	153358332	Missense_Mutation	novel	N17Y	0.12
LGG	chr1	153358408	Missense_Mutation	rs142015410	R42Q	0.32
LGG	chr1	153358351	Missense_Mutation	novel	S23Y	0.36
LIHC	chr1	153360949	3'UTR	novel		0.48
LUAD	chr1	153360756	Nonsense_Mutation	novel	W88*	0.28
MESO	chr1	153360666	Missense_Mutation	novel	V58D	0.24
MESO	chr1	153360667	Silent	novel	V58V	0.24
OV	chr1	153360838	Nonstop_Mutation	NA	115Yext24	0.24
SKCM	chr1	153360643	Splice_Site	novel	X51_splice	0.43
SKCM	chr1	153358376	Silent	NA	T31T	0.31
SKCM	chr1	153360671	Missense_Mutation	NA	E60K	0.31
SKCM	chr1	153360730	Silent	NA	F79F	0.38
SKCM	chr1	153358387	Missense_Mutation	NA	G35E	0.35
SKCM	chr1	153360707	Missense_Mutation	novel	K72Q	0.41
SKCM	chr1	153360876	3'UTR	novel		0.65
SKCM	chr1	153358389	Missense_Mutation	NA	E36K	0.14
SKCM	chr1	153360726	Missense_Mutation	NA	E78V	0.31
SKCM	chr1	153358428	Missense_Mutation	novel	L49F	0.19
SKCM	chr1	153358385	Silent	NA	Q34Q	0.47
SKCM	chr1	153360762	Missense_Mutation	NA	S90F	0.35
SKCM	chr1	153358336	Missense_Mutation	novel	T18I	0.39
STAD	chr1	153358397	Silent	NA	K38K	0.44
STAD	chr1	153360752	Missense_Mutation	NA	T87P	0.14
UCEC	chr1	153358381	Missense_Mutation	novel	N33S	0.38
UCEC	chr1	153360744	Missense_Mutation	rs147137403	A84V	0.49
UCEC	chr1	153360787	Silent	rs140431183	D98D	0.47
UCEC	chr1	153358359	Missense_Mutation	novel	L26M	0.13
UCEC	chr1	153358311	Missense_Mutation	rs140601192	R10C	0.37
UCEC	chr1	153358349	Silent	novel	Y22Y	0.45
UCEC	chr1	153358407	Nonsense_Mutation	NA	R42*	0.18

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1444	0.11282
CESC	AMP	0.4847	3.2002e-05
DLBC	DEL	0.0417	0.0017831
ESCA	AMP	0.4185	0.0022446
KIRC	AMP	0.0928	0.059566
LUSC	AMP	0.4331	1.6618e-06
PAAD	AMP	0.2228	0.085665
PCPG	AMP	0.1481	0.00029562
READ	AMP	0.2667	0.025154
SARC	AMP	0.3502	4.3422e-08
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.3533	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.013	Kaplan-Meier Survival Analysis
SARC	0.028	Kaplan-Meier Survival Analysis
HNSC	0.024	Kaplan-Meier Survival Analysis
BLCA	0.011	Kaplan-Meier Survival Analysis
CESC	0.037	Kaplan-Meier Survival Analysis
LAML	0.027	Kaplan-Meier Survival Analysis
UCEC	0.0018	Kaplan-Meier Survival Analysis
GBM	0.039	Kaplan-Meier Survival Analysis
LIHC	0.00039	Kaplan-Meier Survival Analysis
LGG	0.0065	Kaplan-Meier Survival Analysis
LUAD	0.021	Kaplan-Meier Survival Analysis
UVM	0.0086	Kaplan-Meier Survival Analysis
OV	0.018	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000163220 (Gene tree)
Gene ID: 6280
Gene Symbol: S100A9
Alias: P14|MIF|NIF|LIAG|MRP14|MAC387|60B8AG|CGLB|CAGB|CFAG
Full Name: S100 calcium binding protein A9
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 3,174 bases
Position: chr1:153,357,854-153,361,027
Accession: 10499
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22902790	Quantitative polymerase chain reaction profiling of immunomarkers in rejecting kidney allografts for predicting response to steroid treatment.	Transplantation	2012 Sep 27	Rekers NV	-
12798355	Studies on the development of resistance to the pure antiestrogen Faslodex in three human breast cancer cell lines.	J Steroid Biochem Mol Biol	2003 May	Sommer A	-
11463791	The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes.	J Biol Chem	2001 Sep 21	Thorey IS	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368738	S100A9-201	577	-	ENSP00000357727	114 (aa)	-	P06702

Gene Model

Click here to download ENSG00000163220's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04657	IL-17 signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163220	Child Development Disorders, Pervasive	4.3329000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163220	rs2916193	1	153359373	G	Blood protein levels	30072576	[0.17-0.28] unit increase	0.223	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163220's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001816	cytokine production	22489132.	TAS	Process
GO:0002224	toll-like receptor signaling pathway	-	TAS	Process
GO:0002523	leukocyte migration involved in inflammatory response	12626582.	IDA	Process
GO:0005509	calcium ion binding	22489132.	TAS	Function
GO:0005515	protein binding	9867828.17620599.20936779.25417112.	IPI	Function
GO:0005576	extracellular region	27068509.	HDA	Component
GO:0005576	extracellular region	22489132.	TAS	Component
GO:0005615	extracellular space	16502470.22664934.23580065.	HDA	Component
GO:0005615	extracellular space	21805676.	IDA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	12874352.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	22489132.	TAS	Component
GO:0005856	cytoskeleton	22489132.	TAS	Component
GO:0005886	plasma membrane	22489132.	TAS	Component
GO:0006914	autophagy	19935772.	IDA	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	19935772.	IDA	Process
GO:0006954	inflammatory response	3313057.	TAS	Process
GO:0007267	cell-cell signaling	3313057.	TAS	Process
GO:0008017	microtubule binding	22489132.	TAS	Function
GO:0008270	zinc ion binding	22489132.	TAS	Function
GO:0010976	positive regulation of neuron projection development	-	ISS	Process
GO:0016209	antioxidant activity	-	IEA	Function
GO:0019730	antimicrobial humoral response	-	TAS	Process
GO:0030054	cell junction	-	IDA	Component
GO:0030307	positive regulation of cell growth	22489132.	TAS	Process
GO:0030593	neutrophil chemotaxis	12626582.	IDA	Process
GO:0032119	sequestering of zinc ion	22489132.	TAS	Process
GO:0032602	chemokine production	22489132.	TAS	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0035606	peptidyl-cysteine S-trans-nitrosylation	25417112.	IDA	Process
GO:0035662	Toll-like receptor 4 binding	22489132.	TAS	Function
GO:0035821	modification of morphology or physiology of other organism	12874352.	IDA	Process
GO:0042742	defense response to bacterium	22489132.	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0050544	arachidonic acid binding	22489132.	TAS	Function
GO:0050729	positive regulation of inflammatory response	12626582.	IDA	Process
GO:0050786	RAGE receptor binding	22489132.	TAS	Function
GO:0050832	defense response to fungus	22489132.	TAS	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	22489132.	TAS	Process
GO:0051493	regulation of cytoskeleton organization	22489132.	TAS	Process
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	12874352.	IDA	Process
GO:0062023	collagen-containing extracellular matrix	23979707.25037231.28344315.28675934.	HDA	Component
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component
GO:0070488	neutrophil aggregation	12626582.	IDA	Process
GO:0098869	cellular oxidant detoxification	-	IEA	Process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	19935772.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.