EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29733516Clinical significance of calcium-binding protein S100A8 and S100A9 expression in non-small cell lung cancer.Thorac Cancer2018 JulHuang Hdoi: 10.1111/1759-7714.12649
26397389Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9.Oncol Rep2015 DecHsu YLdoi: 10.3892/or.2015.4307
26404752A pro-tumorigenic function of S100A8/A9 in carcinogen-induced hepatocellular carcinoma.Cancer Lett2015 Dec 28De Ponti Adoi: 10.1016/j.canlet.2015.09.005
28983059Pro-inflammatory proteins S100A9 and tumor necrosis factor-α suppress erythropoietin elaboration in myelodysplastic syndromes.Haematologica2017 DecCluzeau Tdoi: 10.3324/haematol.2016.158857
15069705Loss of myeloid-related proteins 8 and myeloid-related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiation.World J Gastroenterol2004 Apr 15Kong JP-
15075348Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions.J Leukoc Biol2004 JulGhavami S-
21228116S100A8/A9 activate key genes and pathways in colon tumor progression.Mol Cancer Res2011 FebIchikawa Mdoi: 10.1158/1541-7786.MCR-10-0394
18689872RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.Carcinogenesis2008 OctTurovskaya Odoi: 10.1093/carcin/bgn188
17126494On the mechanism of apoptosis-inducing activity of human calprotectin: zinc sequestration, induction of a signaling pathway, or something else?Med Hypotheses2007Zali H-
22864818Roles of galectin-7 and S100A9 in cervical squamous carcinoma: Clinicopathological and in vitro evidence.Int J Cancer2013 Mar 1Zhu Hdoi: 10.1002/ijc.27764
22634002The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment.Biochem Biophys Res Commun2012 Jun 22Kim JHdoi: 10.1016/j.bbrc.2012.05.081
27086923Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.Oncogene2016 Nov 3Lim SYdoi: 10.1038/onc.2016.107
22838504Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer.BMC Cancer2012 Jul 28Fan Bdoi: 10.1186/1471-2407-12-316.
22691358[Expression and clinical significance of calcium-binding protein S100A9 in breast cancer].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2012 JunDu XM-
23248262Increased myeloid-derived suppressor cells in gastric cancer correlate with cancer stage and plasma S100A8/A9 proinflammatory proteins.J Immunol2013 Jan 15Wang Ldoi: 10.4049/jimmunol.1202088
20819668Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features.Chin Med J (Engl)2010 AugSu YJ-
24122301Impact of S100A8/A9 expression on prostate cancer progression in vitro and in vivo.J Cell Physiol2014 MayGrebhardt Sdoi: 10.1002/jcp.24489.
22074005Proteomic approach reveals FKBP4 and S100A9 as potential prediction markers of therapeutic response to neoadjuvant chemotherapy in patients with breast cancer.J Proteome Res2012 Feb 3Yang WSdoi: 10.1021/pr2008187
24726733High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome.Eur J Cancer2014 JulTidehag Vdoi: 10.1016/j.ejca.2014.03.278
22505354Hypoxia and HIF-1 increase S100A8 and S100A9 expression in prostate cancer.Int J Cancer2012 Dec 15Grebhardt Sdoi: 10.1002/ijc.27591
24041228Intracellular expression of inflammatory proteins S100A8 and S100A9 leads to epithelial-mesenchymal transition and attenuated aggressivity of breast cancer cells.Anticancer Agents Med Chem2014 JanCormier K-
23456298S100A8 and S100A9 promotes invasion and migration through p38 mitogen-activated protein kinase-dependent NF-??B activation in gastric cancer cells.Mol Cells2013 MarKwon CHdoi: 10.1007/s10059-013-2269-x
24948111ID1 promotes breast cancer metastasis by S100A9 regulation.Mol Cancer Res2014 SepGumireddy Kdoi: 10.1158/1541-7786.MCR-14-0049
25236491S100A8/A9 regulates MMP-2 expression and invasion and migration by carcinoma cells.Int J Biochem Cell Biol2014 OctSilva EJdoi: 10.1016/j.biocel.2014.09.007
24177755RAGE-binding S100A8/A9 promotes the migration and invasion of human breast cancer cells through actin polymerization and epithelial-mesenchymal transition.Breast Cancer Res Treat2013 NovYin Cdoi: 10.1007/s10549-013-2737-1
22622474Elevated levels of proliferating and recently migrated tumor-associated macrophages confer increased aggressiveness and worse outcomes in breast cancer.Ann Surg Oncol2012 NovMukhtar RAdoi: 10.1245/s10434-012-2415-2
25348783Comparison of mRNA, Protein, and Urinary Nucleic Acid Levels of S100A8 and S100A9 between Prostate Cancer and BPH.Ann Surg Oncol2015 JulYun SJdoi: 10.1245/s10434-014-4194-4
21799753The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC.PLoS One2011Ohri CMdoi: 10.1371/journal.pone.0021874
21369941Prognostic impact of S100A9 overexpression in non-small cell lung cancer.Tumour Biol2011 AugKawai Hdoi: 10.1007/s13277-011-0163-8
22304731S100A9 a new marker for monocytic human myeloid-derived suppressor cells.Immunology2012 JunZhao Fdoi: 10.1111/j.1365-2567.2012.03566.x.
26653550Diagnostic importance of S100A9 and S100A12 in breast cancer.Biomed Pharmacother2015 DecGunaldi Mdoi: 10.1016/j.biopha.2015.10.029
24631944S100A9 and EGFR gene signatures predict disease progression in muscle invasive bladder cancer patients after chemotherapy.Ann Oncol2014 MayKim WTdoi: 10.1093/annonc/mdu037
26713053Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer.J Korean Med Sci2015 DecYan Cdoi: 10.3346/jkms.2015.30.12.1784
15040889Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer.Cell Res2004 FebWang J-
23637971S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway.PLoS One2013 Apr 26Duan Ldoi: 10.1371/journal.pone.0062092
26315114Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production.Oncotarget2015 Sep 29Fang WYdoi: 10.18632/oncotarget.4951.
27191989Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis.Oncotarget2016 Jun 14Li Mdoi: 10.18632/oncotarget.9362.
28036279Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116.Oncotarget2017 Jan 24Myung JKdoi: 10.18632/oncotarget.14301.
28609200Significance of S100A8, S100A9 and calprotectin levels in bladder cancer.Scand J Clin Lab Invest2017 OctYasar Odoi: 10.1080/00365513.2017.1336567

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr11533609653'UTRnovel0.1
BLCAchr1153360704Missense_MutationNAD71N0.41
BLCAchr1153360649SilentnovelE52E0.25
BLCAchr1153358311Missense_Mutationrs140601192R10C0.25
CESCchr1153358312Missense_MutationNAR10P0.49
COADchr1153358408Missense_Mutationrs142015410R42Q0.3
COADchr1153358300Missense_MutationNAS6L0.31
HNSCchr1153358332Missense_MutationnovelN17Y0.12
LGGchr1153358408Missense_Mutationrs142015410R42Q0.32
LGGchr1153358351Missense_MutationnovelS23Y0.36
LIHCchr11533609493'UTRnovel0.48
LUADchr1153360756Nonsense_MutationnovelW88*0.28
MESOchr1153360666Missense_MutationnovelV58D0.24
MESOchr1153360667SilentnovelV58V0.24
OVchr1153360838Nonstop_MutationNA*115Yext*240.24
SKCMchr1153360643Splice_SitenovelX51_splice0.43
SKCMchr1153358376SilentNAT31T0.31
SKCMchr1153360671Missense_MutationNAE60K0.31
SKCMchr1153360730SilentNAF79F0.38
SKCMchr1153358387Missense_MutationNAG35E0.35
SKCMchr1153360707Missense_MutationnovelK72Q0.41
SKCMchr11533608763'UTRnovel0.65
SKCMchr1153358389Missense_MutationNAE36K0.14
SKCMchr1153360726Missense_MutationNAE78V0.31
SKCMchr1153358428Missense_MutationnovelL49F0.19
SKCMchr1153358385SilentNAQ34Q0.47
SKCMchr1153360762Missense_MutationNAS90F0.35
SKCMchr1153358336Missense_MutationnovelT18I0.39
STADchr1153358397SilentNAK38K0.44
STADchr1153360752Missense_MutationNAT87P0.14
UCECchr1153358381Missense_MutationnovelN33S0.38
UCECchr1153360744Missense_Mutationrs147137403A84V0.49
UCECchr1153360787Silentrs140431183D98D0.47
UCECchr1153358359Missense_MutationnovelL26M0.13
UCECchr1153358311Missense_Mutationrs140601192R10C0.37
UCECchr1153358349SilentnovelY22Y0.45
UCECchr1153358407Nonsense_MutationNAR42*0.18

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.14440.11282
CESCAMP0.48473.2002e-05
DLBCDEL0.04170.0017831
ESCAAMP0.41850.0022446
KIRCAMP0.09280.059566
LUSCAMP0.43311.6618e-06
PAADAMP0.22280.085665
PCPGAMP0.14810.00029562
READAMP0.26670.025154
SARCAMP0.35024.3422e-08
SKCMAMP0.48779.6912e-06
TGCTAMP0.35330.088103

Survival Analysis
CancerP-value Q-value
KIRC0.013

Kaplan-Meier Survival Analysis

SARC0.028

Kaplan-Meier Survival Analysis

HNSC0.024

Kaplan-Meier Survival Analysis

BLCA0.011

Kaplan-Meier Survival Analysis

CESC0.037

Kaplan-Meier Survival Analysis

LAML0.027

Kaplan-Meier Survival Analysis

UCEC0.0018

Kaplan-Meier Survival Analysis

GBM0.039

Kaplan-Meier Survival Analysis

LIHC0.00039

Kaplan-Meier Survival Analysis

LGG0.0065

Kaplan-Meier Survival Analysis

LUAD0.021

Kaplan-Meier Survival Analysis

UVM0.0086

Kaplan-Meier Survival Analysis

OV0.018

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000163220 (Gene tree)
Gene ID
6280
Gene Symbol
S100A9
Alias
P14|MIF|NIF|LIAG|MRP14|MAC387|60B8AG|CGLB|CAGB|CFAG
Full Name
S100 calcium binding protein A9
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
3,174 bases
Position
chr1:153,357,854-153,361,027
Accession
10499
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22902790Quantitative polymerase chain reaction profiling of immunomarkers in rejecting kidney allografts for predicting response to steroid treatment.Transplantation2012 Sep 27Rekers NV-
12798355Studies on the development of resistance to the pure antiestrogen Faslodex in three human breast cancer cell lines.J Steroid Biochem Mol Biol2003 MaySommer A-
11463791The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes.J Biol Chem2001 Sep 21Thorey IS-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000368738S100A9-201577-ENSP00000357727114 (aa)-P06702
Gene Model
Click here to download ENSG00000163220's gene model file
Pathways
Pathway IDPathway NameSource
hsa04657IL-17 signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000163220Child Development Disorders, Pervasive4.3329000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000163220rs29161931153359373GBlood protein levels30072576[0.17-0.28] unit increase0.223EFO_0007937
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163220's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001816cytokine production22489132.TASProcess
GO:0002224toll-like receptor signaling pathway-TASProcess
GO:0002523leukocyte migration involved in inflammatory response12626582.IDAProcess
GO:0005509calcium ion binding22489132.TASFunction
GO:0005515protein binding9867828.17620599.20936779.25417112.IPIFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005576extracellular region22489132.TASComponent
GO:0005615extracellular space16502470.22664934.23580065.HDAComponent
GO:0005615extracellular space21805676.IDAComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm12874352.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol22489132.TASComponent
GO:0005856cytoskeleton22489132.TASComponent
GO:0005886plasma membrane22489132.TASComponent
GO:0006914autophagy19935772.IDAProcess
GO:0006915apoptotic process-IEAProcess
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process19935772.IDAProcess
GO:0006954inflammatory response3313057.TASProcess
GO:0007267cell-cell signaling3313057.TASProcess
GO:0008017microtubule binding22489132.TASFunction
GO:0008270zinc ion binding22489132.TASFunction
GO:0010976positive regulation of neuron projection development-ISSProcess
GO:0016209antioxidant activity-IEAFunction
GO:0019730antimicrobial humoral response-TASProcess
GO:0030054cell junction-IDAComponent
GO:0030307positive regulation of cell growth22489132.TASProcess
GO:0030593neutrophil chemotaxis12626582.IDAProcess
GO:0032119sequestering of zinc ion22489132.TASProcess
GO:0032602chemokine production22489132.TASProcess
GO:0034774secretory granule lumen-TASComponent
GO:0035606peptidyl-cysteine S-trans-nitrosylation25417112.IDAProcess
GO:0035662Toll-like receptor 4 binding22489132.TASFunction
GO:0035821modification of morphology or physiology of other organism12874352.IDAProcess
GO:0042742defense response to bacterium22489132.TASProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0045087innate immune response-IEAProcess
GO:0050544arachidonic acid binding22489132.TASFunction
GO:0050729positive regulation of inflammatory response12626582.IDAProcess
GO:0050786RAGE receptor binding22489132.TASFunction
GO:0050832defense response to fungus22489132.TASProcess
GO:0051092positive regulation of NF-kappaB transcription factor activity22489132.TASProcess
GO:0051493regulation of cytoskeleton organization22489132.TASProcess
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide12874352.IDAProcess
GO:0062023collagen-containing extracellular matrix23979707.25037231.28344315.28675934.HDAComponent
GO:0070062extracellular exosome19056867.19199708.23533145.HDAComponent
GO:0070488neutrophil aggregation12626582.IDAProcess
GO:0098869cellular oxidant detoxification-IEAProcess
GO:2001244positive regulation of intrinsic apoptotic signaling pathway19935772.IDAProcess
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