EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25994790	Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase.	Am J Physiol Cell Physiol	2015 Jul 15	Cherniavsky Lev M	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	116384813	Missense_Mutation	novel	H52N	0.39
BLCA	chr1	116389443	Silent	rs776666372	T253T	0.19
BLCA	chr1	116389613	Missense_Mutation	NA	S310C	0.23
BLCA	chr1	116390355	Frame_Shift_Del	novel	*H390Tfs68**	0.35
BLCA	chr1	116392944	Missense_Mutation	rs148719009	A475T	0.11
BLCA	chr1	116395260	Missense_Mutation	novel	G604D	0.42
BLCA	chr1	116399502	Missense_Mutation	novel	L844R	0.48
BLCA	chr1	116403974	Splice_Region	NA	G1014G	0.4
BLCA	chr1	116398671	Silent	NA	L725L	0.15
BLCA	chr1	116388969	Missense_Mutation	novel	N235T	0.13
BLCA	chr1	116404461	3'UTR	novel		0.18
BLCA	chr1	116395222	Missense_Mutation	novel	M591I	0.45
BLCA	chr1	116403964	Missense_Mutation	rs758090295	R1011Q	0.12
BLCA	chr1	116389639	Missense_Mutation	novel	E319Q	0.44
BRCA	chr1	116399421	Missense_Mutation	NA	V817A	0.33
BRCA	chr1	116399171	Intron	novel		0.17
BRCA	chr1	116385136	Intron	novel		0.24
BRCA	chr1	116388930	Nonsense_Mutation	NA	S222*	0.31
BRCA	chr1	116393597	Missense_Mutation	NA	E512K	0.15
BRCA	chr1	116393616	Missense_Mutation	NA	C518Y	0.27
BRCA	chr1	116404508	3'UTR	novel		0.21
BRCA	chr1	116384071	Frame_Shift_Del	NA	*K25Rfs11**	0.27
BRCA	chr1	116387312	Missense_Mutation	NA	E70Q	0.2
BRCA	chr1	116393585	Missense_Mutation	NA	K508Q	0.17
BRCA	chr1	116398671	Missense_Mutation	NA	L725F	0.13
BRCA	chr1	116401067	Intron	novel		0.06
BRCA	chr1	116390782	Missense_Mutation	NA	G408D	0.61
BRCA	chr1	116385198	Intron	novel		0.33
CESC	chr1	116388635	Splice_Region	novel		0.4
CESC	chr1	116390395	Frame_Shift_Del	novel	*T403Qfs55**	0.38
CESC	chr1	116400932	Missense_Mutation	novel	H882Y	0.1
CESC	chr1	116399003	Silent	rs200315945	P789P	0.48
CESC	chr1	116392854	Missense_Mutation	novel	R445W	0.24
CESC	chr1	116401066	Intron	novel		0.18
CESC	chr1	116374152	Intron	NA		0.42
COAD	chr1	116384071	Frame_Shift_Del	NA	*K25Rfs11**	0.39
COAD	chr1	116397912	Silent	rs377724625	H666H	0.26
COAD	chr1	116395242	Missense_Mutation	NA	A598V	0.17
COAD	chr1	116398001	Missense_Mutation	NA	Q696R	0.35
COAD	chr1	116405871	3'Flank	novel		0.3
COAD	chr1	116373426	5'UTR	novel		0.32
COAD	chr1	116387306	Missense_Mutation	novel	A68T	0.45
COAD	chr1	116388982	Silent	rs561066145	T239T	0.23
COAD	chr1	116399003	Silent	rs200315945	P789P	0.07
COAD	chr1	116405571	3'Flank	novel		0.34
COAD	chr1	116387396	Frame_Shift_Del	NA	*F100Sfs41**	0.44
COAD	chr1	116399211	Intron	novel		0.7
COAD	chr1	116396613	Nonsense_Mutation	NA	G618*	0.34
COAD	chr1	116405780	3'Flank	novel		0.17
COAD	chr1	116406142	3'Flank	novel		0.5
COAD	chr1	116401180	Silent	rs745657240	F923F	0.4
COAD	chr1	116405598	3'Flank	novel		0.37
COAD	chr1	116393671	Silent	rs142766448	D536D	0.26
COAD	chr1	116384071	Frame_Shift_Del	NA	*K25Rfs11**	0.35
COAD	chr1	116401151	Missense_Mutation	NA	V914M	0.37
COAD	chr1	116403922	In_Frame_Del	NA	I998del	0.36
COAD	chr1	116395151	Missense_Mutation	novel	G568W	0.09
COAD	chr1	116403947	Frame_Shift_Del	novel	*K1006Nfs54**	0.37
COAD	chr1	116388687	Missense_Mutation	novel	E184G	0.06
COAD	chr1	116387482	Missense_Mutation	NA	Q126H	0.13
COAD	chr1	116401563	Silent	NA	I953I	0.07
COAD	chr1	116387396	Frame_Shift_Del	NA	*F100Sfs41**	0.27
COAD	chr1	116384098	Missense_Mutation	novel	D33Y	0.05
COAD	chr1	116405972	3'Flank	novel		0.06
COAD	chr1	116393591	Missense_Mutation	NA	A510T	0.24
ESCA	chr1	116384071	Frame_Shift_Del	NA	*K25Rfs11**	0.32
ESCA	chr1	116389564	Missense_Mutation	novel	I294F	0.23
ESCA	chr1	116374177	Intron	novel		0.29
ESCA	chr1	116384840	Missense_Mutation	novel	R61W	0.33
ESCA	chr1	116388226	Frame_Shift_Ins	novel	*N163Kfs14**	0.31
GBM	chr1	116397904	Missense_Mutation	rs200285355	V664I	0.05
GBM	chr1	116399129	Intron	novel		0.43
GBM	chr1	116403974	Splice_Region	NA	G1014G	0.26
GBM	chr1	116396684	Silent	novel	V641V	0.1
GBM	chr1	116397968	Missense_Mutation	novel	H685L	0.05
GBM	chr1	116399508	Missense_Mutation	novel	N846S	0.17
GBM	chr1	116397991	Missense_Mutation	novel	T693A	0.29
HNSC	chr1	116401585	Missense_Mutation	novel	E961Q	0.26
HNSC	chr1	116401041	Intron	novel		0.27
HNSC	chr1	116403963	Silent	novel	R1011R	0.26
HNSC	chr1	116384790	Missense_Mutation	novel	H44R	0.35
HNSC	chr1	116398777	Nonsense_Mutation	novel	*G761Efs3**	0.05
HNSC	chr1	116398932	Missense_Mutation	novel	R766C	0.06
HNSC	chr1	116399088	Splice_Region	novel		0.1
HNSC	chr1	116396595	Splice_Region	novel		0.42
KIRC	chr1	116390360	Missense_Mutation	novel	M391V	0.29
KIRC	chr1	116395270	Silent	NA	R607R	0.22
KIRC	chr1	116396627	Missense_Mutation	NA	I622M	0.18
KIRC	chr1	116390336	Missense_Mutation	NA	Q383K	0.21
KIRP	chr1	116388954	Missense_Mutation	NA	D230A	0.43
KIRP	chr1	116388662	Missense_Mutation	novel	E176K	0.4
KIRP	chr1	116398715	Missense_Mutation	NA	D740G	0.4
KIRP	chr1	116398778	Missense_Mutation	rs11540954	G761A	0.31
LAML	chr1	116403973	Missense_Mutation	novel	G1014V	0.09
LIHC	chr1	116392891	Frame_Shift_Ins	novel	*C459Vfs36**	0.3
LIHC	chr1	116397947	Missense_Mutation	novel	L678P	0.17
LIHC	chr1	116390403	Missense_Mutation	NA	N405T	0.11
LIHC	chr1	116405858	3'Flank	NA		0.13
LIHC	chr1	116405990	3'Flank	novel		0.5
LIHC	chr1	116405869	3'Flank	novel		0.32
LIHC	chr1	116389702	Missense_Mutation	NA	V340I	0.34
LIHC	chr1	116390403	Missense_Mutation	NA	N405T	0.35
LUAD	chr1	116392931	Missense_Mutation	NA	M470I	0.13
LUAD	chr1	116395269	Missense_Mutation	NA	R607Q	0.2
LUAD	chr1	116399003	Silent	rs200315945	P789P	0.07
LUAD	chr1	116397979	Missense_Mutation	novel	V689L	0.06
LUAD	chr1	116398735	Missense_Mutation	NA	D747H	0.5
LUAD	chr1	116398991	Silent	rs144039896	P785P	0.28
LUAD	chr1	116401633	Missense_Mutation	novel	A977P	0.04
LUAD	chr1	116397936	Silent	NA	T674T	0.21
LUAD	chr1	116398732	Missense_Mutation	NA	A746T	0.5
LUSC	chr1	116400916	Silent	rs368053168	N876N	0.21
LUSC	chr1	116397906	Silent	NA	V664V	0.5
LUSC	chr1	116387322	Missense_Mutation	rs751968061	A73V	0.16
LUSC	chr1	116373486	5'UTR	novel		0.5
LUSC	chr1	116399213	Intron	novel		0.11
OV	chr1	116388709	Silent	novel	V191V	0.04
OV	chr1	116399157	Intron	novel		0.2
OV	chr1	116401060	Intron	novel		0.06
OV	chr1	116390342	Missense_Mutation	rs775243249	R385W	0.52
OV	chr1	116392933	Missense_Mutation	NA	R471K	0.04
OV	chr1	116388952	In_Frame_Ins	novel	P229_D230insTLPSLCWYTN	0.1
OV	chr1	116388954	Missense_Mutation	novel	D230G	0.01
OV	chr1	116393671	Silent	rs142766448	D536D	0.04
OV	chr1	116385053	Intron	novel		0.1
OV	chr1	116388710	Nonsense_Mutation	novel	E192*	0.12
PAAD	chr1	116387468	Nonsense_Mutation	novel	E122*	0.03
PAAD	chr1	116401208	Missense_Mutation	novel	D933N	0.07
PRAD	chr1	116399157	Intron	novel		0.11
READ	chr1	116388244	Frame_Shift_Ins	novel	*Q168Lfs5**	0.07
READ	chr1	116406128	3'Flank	novel		0.33
READ	chr1	116390844	Missense_Mutation	novel	N429D	0.4
READ	chr1	116401180	Silent	rs745657240	F923F	0.41
READ	chr1	116401150	Silent	rs114525271	I913I	0.16
SKCM	chr1	116390825	Silent	NA	S422S	0.33
SKCM	chr1	116395229	Missense_Mutation	novel	P594S	0.44
SKCM	chr1	116384899	Intron	novel		0.3
SKCM	chr1	116395230	Missense_Mutation	NA	P594L	0.11
SKCM	chr1	116401247	Nonsense_Mutation	NA	Q946*	0.11
SKCM	chr1	116388937	Silent	NA	P224P	0.25
SKCM	chr1	116389587	Silent	NA	F301F	0.58
SKCM	chr1	116389621	Missense_Mutation	NA	L313F	0.54
SKCM	chr1	116393649	Missense_Mutation	novel	P529L	0.48
SKCM	chr1	116398979	Silent	rs779579313	T781T	0.22
SKCM	chr1	116388184	Silent	novel	S147S	0.23
SKCM	chr1	116387350	Silent	novel	P82P	0.14
SKCM	chr1	116392916	Silent	NA	G465G	0.26
STAD	chr1	116403974	Splice_Region	NA	G1014G	0.21
STAD	chr1	116397940	Missense_Mutation	rs768375815	E676K	0.23
STAD	chr1	116398760	Missense_Mutation	NA	F755C	0.43
STAD	chr1	116398750	Missense_Mutation	novel	D752N	0.35
STAD	chr1	116389682	Missense_Mutation	NA	P333L	0.32
STAD	chr1	116398699	Missense_Mutation	NA	G735R	0.33
STAD	chr1	116396688	Missense_Mutation	novel	D643Y	0.55
STAD	chr1	116401000	Missense_Mutation	novel	Q904H	0.42
STAD	chr1	116395190	Missense_Mutation	NA	D581N	0.11
STAD	chr1	116388641	Missense_Mutation	NA	A169T	0.11
STAD	chr1	116398008	Missense_Mutation	novel	K698N	0.14
STAD	chr1	116387383	Missense_Mutation	novel	C93W	0.1
STAD	chr1	116384071	Nonsense_Mutation	novel	K24delinsIQSLWHNQR*	0.07
STAD	chr1	116393570	Frame_Shift_Del	novel	*H503Pfs6**	0.24
STAD	chr1	116392943	Silent	rs140751331	Y474Y	0.42
STAD	chr1	116398959	Missense_Mutation	NA	S775P	0.24
STAD	chr1	116393698	Frame_Shift_Del	rs760784617	*G547Afs7**	0.32
STAD	chr1	116387395	Frame_Shift_Ins	NA	*F100Vfs17**	0.31
STAD	chr1	116384122	Missense_Mutation	NA	M41V	0.32
STAD	chr1	116393698	Frame_Shift_Del	rs760784617	*G547Afs7**	0.28
TGCT	chr1	116397904	Missense_Mutation	rs200285355	V664I	0.14
THCA	chr1	116387323	Silent	rs147430340	A73A	0.25
THCA	chr1	116389679	Missense_Mutation	rs724160010	V332G	0.34
UCEC	chr1	116384109	Missense_Mutation	NA	K36N	0.37
UCEC	chr1	116401563	Silent	NA	I953I	0.34
UCEC	chr1	116384963	Intron	novel		0.39
UCEC	chr1	116387384	Missense_Mutation	novel	R94W	0.35
UCEC	chr1	116405832	3'Flank	novel		0.32
UCEC	chr1	116384020	Frame_Shift_Del	NA	*R7Vfs29**	0.33
UCEC	chr1	116388681	Missense_Mutation	rs139745455	A182V	0.06
UCEC	chr1	116383384	Intron	novel		0.28
UCEC	chr1	116384125	Splice_Site	novel	X41_splice	0.3
UCEC	chr1	116392958	Silent	NA	E479E	0.35
UCEC	chr1	116401039	Intron	novel		0.41
UCEC	chr1	116404561	3'UTR	novel		0.49
UCEC	chr1	116384020	Missense_Mutation	NA	R7C	0.39
UCEC	chr1	116399004	Missense_Mutation	novel	F790V	0.36
UCEC	chr1	116403974	Splice_Region	NA	G1014G	0.38
UCEC	chr1	116393651	Missense_Mutation	novel	L530M	0.34
UCEC	chr1	116392854	Missense_Mutation	novel	R445W	0.5
UCEC	chr1	116401628	Missense_Mutation	NA	G975D	0.22
UCEC	chr1	116374152	Intron	novel		0.26
UCEC	chr1	116384074	Nonsense_Mutation	novel	K25*	0.2
UCEC	chr1	116384962	Intron	novel		0.22
UCEC	chr1	116392944	Missense_Mutation	rs148719009	A475T	0.45
UCEC	chr1	116401102	Intron	novel		0.07
UCEC	chr1	116405696	3'Flank	novel		0.51
UCEC	chr1	116388163	Silent	novel	V140V	0.45
UCEC	chr1	116390850	Missense_Mutation	novel	A431T	0.26
UCEC	chr1	116389588	Missense_Mutation	novel	L302M	0.33
UCEC	chr1	116398038	Splice_Region	novel	Q708Q	0.19
UCEC	chr1	116405796	3'Flank	novel		0.33
UCEC	chr1	116404582	3'UTR	novel		0.21
UCEC	chr1	116404616	3'UTR	novel		0.13
UCEC	chr1	116395190	Missense_Mutation	NA	D581N	0.55
UCEC	chr1	116396701	Missense_Mutation	rs201085928	R647H	0.36
UCEC	chr1	116403938	Silent	rs146071470	D1002D	0.35
UCEC	chr1	116384814	Missense_Mutation	novel	H52R	0.43
UCEC	chr1	116388681	Missense_Mutation	rs139745455	A182V	0.38
UCEC	chr1	116392895	Missense_Mutation	novel	K458N	0.42
UCEC	chr1	116405628	3'Flank	rs778156127		0.41
UCEC	chr1	116406025	3'Flank	novel		0.44
UCEC	chr1	116383431	Intron	novel		0.76
UCEC	chr1	116390252	Missense_Mutation	novel	N355H	0.53
UCEC	chr1	116399003	Nonsense_Mutation	novel	*P789_F790insGYQSL**	0.01
UCEC	chr1	116403931	Missense_Mutation	NA	V1000A	0.35
UCEC	chr1	116388749	Missense_Mutation	novel	I205L	0.41
UCEC	chr1	116388699	Missense_Mutation	novel	G188V	0.34
UCEC	chr1	116390886	Missense_Mutation	novel	L443I	0.3
UCEC	chr1	116399167	Intron	novel		0.63
UCEC	chr1	116405663	3'Flank	rs148084760		0.32
UCEC	chr1	116387474	Missense_Mutation	novel	E124K	0.47
UCEC	chr1	116390343	Missense_Mutation	NA	R385Q	0.29
UCEC	chr1	116405749	3'Flank	novel		0.36
UCEC	chr1	116384075	Missense_Mutation	novel	K25R	0.43
UCEC	chr1	116393551	Silent	novel	P496P	0.09
UCEC	chr1	116395269	Missense_Mutation	NA	R607Q	0.31
UCEC	chr1	116393559	Missense_Mutation	rs141400264	S499L	0.42
UCEC	chr1	116388654	Missense_Mutation	novel	R173Q	0.07
UCEC	chr1	116390873	Silent	novel	E438E	0.05
UCEC	chr1	116387432	Missense_Mutation	novel	L110I	0.29
UCEC	chr1	116389489	Missense_Mutation	novel	R269G	0.18
UCEC	chr1	116384963	Intron	novel		0.22
UCEC	chr1	116399075	Silent	rs111483355	G813G	0.3
UCEC	chr1	116404560	3'UTR	rs772774743		0.45
UCEC	chr1	116390343	In_Frame_Ins	novel	A389_H390insSKPSGTLATMIPMRKMTVA	0.06
UCEC	chr1	116404616	3'UTR	novel		0.3
UCEC	chr1	116387319	Missense_Mutation	NA	L72P	0.34
UCEC	chr1	116389660	Missense_Mutation	novel	G326C	0.12
UCEC	chr1	116395219	Silent	novel	S590S	0.06
UCEC	chr1	116388204	Missense_Mutation	NA	S154I	0.43
UCEC	chr1	116395269	Missense_Mutation	NA	R607Q	0.38
UCEC	chr1	116374185	Intron	novel		0.09
UCEC	chr1	116403939	Missense_Mutation	NA	E1003K	0.34
UCEC	chr1	116401560	Silent	NA	K952K	0.31
UCEC	chr1	116390217	Missense_Mutation	novel	C343Y	0.09
UCEC	chr1	116398630	Missense_Mutation	novel	V712M	0.27
UCEC	chr1	116387430	Missense_Mutation	NA	I109S	0.25
UCEC	chr1	116390892	Splice_Site	NA	X444_splice	0.27
UCEC	chr1	116384115	Missense_Mutation	novel	E38D	0.36
UCEC	chr1	116388946	Silent	novel	R227R	0.24
UCEC	chr1	116401239	Missense_Mutation	novel	S943L	0.58
UCEC	chr1	116406025	3'Flank	novel		0.28
UCEC	chr1	116384021	Missense_Mutation	rs146195513	R7H	0.31
UCEC	chr1	116389452	Silent	novel	G256G	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2093	5.7821e-10
CESC	DEL	0.0949	0.01281
COAD	DEL	0.2106	0.00038973
DLBC	DEL	0.1875	0.0017831
ESCA	DEL	0.2554	8.8025e-06
HNSC	DEL	0.2088	7.836e-19
LUAD	DEL	0.2287	2.5961e-13
LUSC	DEL	0.3892	1.8628e-17
READ	DEL	0.2545	0.013822
SKCM	DEL	0.1689	9.7877e-07
STAD	DEL	0.1723	0.0040659
TGCT	AMP	0.2	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.0026	Kaplan-Meier Survival Analysis
ESCA	0.029	Kaplan-Meier Survival Analysis
KIRP	0.015	Kaplan-Meier Survival Analysis
BLCA	0.00049	Kaplan-Meier Survival Analysis
LAML	0.0057	Kaplan-Meier Survival Analysis
LIHC	0.00039	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
OV	0.02	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163399 (Gene tree)
Gene ID: 476
Gene Symbol: ATP1A1
Alias: N
Full Name: ATPase Na+/K+ transporting subunit alpha 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 38,077 bases
Position: chr1:116,372,185-116,410,261
Accession: 799
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491156	ATP1A1-209	666	-	-	- (aa)	-	-
ENST00000369494	ATP1A1-202	698	-	ENSP00000358506	144 (aa)	-	Q5TC01
ENST00000369496	ATP1A1-203	3572	-	ENSP00000358508	992 (aa)	-	P05023
ENST00000495965	ATP1A1-210	417	-	-	- (aa)	-	-
ENST00000537345	ATP1A1-211	3763	XM_017001360	ENSP00000445306	1023 (aa)	XP_016856849	P05023
ENST00000418797	ATP1A1-204	654	-	ENSP00000400124	106 (aa)	-	Q5TC02
ENST00000479960	ATP1A1-207	611	-	-	- (aa)	-	-
ENST00000488733	ATP1A1-208	1728	-	-	- (aa)	-	-
ENST00000295598	ATP1A1-201	3654	-	ENSP00000295598	1023 (aa)	-	P05023
ENST00000463382	ATP1A1-206	584	-	-	- (aa)	-	-
ENST00000440951	ATP1A1-205	579	-	ENSP00000396236	157 (aa)	-	Q5TC05

Gene Model

Click here to download ENSG00000163399's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04260	Cardiac muscle contraction	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04911	Insulin secretion	KEGG
hsa04918	Thyroid hormone synthesis	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04925	Aldosterone synthesis and secretion	KEGG
hsa04960	Aldosterone-regulated sodium reabsorption	KEGG
hsa04961	Endocrine and other factor-regulated calcium reabsorption	KEGG
hsa04964	Proximal tubule bicarbonate reclamation	KEGG
hsa04970	Salivary secretion	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa04972	Pancreatic secretion	KEGG
hsa04973	Carbohydrate digestion and absorption	KEGG
hsa04974	Protein digestion and absorption	KEGG
hsa04976	Bile secretion	KEGG
hsa04978	Mineral absorption	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163399's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163399	ATP1A1	100	97.077	ENSMUSG00000033161	Atp1a1	100	96.872	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002026	regulation of the force of heart contraction	-	IEA	Process
GO:0002028	regulation of sodium ion transport	-	ISS	Process
GO:0005391	sodium:potassium-exchanging ATPase activity	21873635.	IBA	Function
GO:0005391	sodium:potassium-exchanging ATPase activity	10636900.19542013.	IDA	Function
GO:0005391	sodium:potassium-exchanging ATPase activity	-	ISS	Function
GO:0005391	sodium:potassium-exchanging ATPase activity	-	ISS	Function
GO:0005515	protein binding	11027149.15671290.16730713.18504258.21278788.22084111.25012180.30021884.	IPI	Function
GO:0005524	ATP binding	-	ISS	Function
GO:0005768	endosome	-	IEA	Component
GO:0005783	endoplasmic reticulum	-	ISS	Component
GO:0005794	Golgi apparatus	-	ISS	Component
GO:0005886	plasma membrane	16791210.	HDA	Component
GO:0005886	plasma membrane	7711835.18522992.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005890	sodium:potassium-exchanging ATPase complex	10636900.19542013.	IDA	Component
GO:0005890	sodium:potassium-exchanging ATPase complex	-	ISS	Component
GO:0005901	caveola	-	IEA	Component
GO:0006883	cellular sodium ion homeostasis	21873635.	IBA	Process
GO:0006883	cellular sodium ion homeostasis	10636900.19542013.	IDA	Process
GO:0008217	regulation of blood pressure	-	IEA	Process
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	-	IEA	Process
GO:0014069	postsynaptic density	-	IEA	Component
GO:0014704	intercalated disc	-	IEA	Component
GO:0015991	ATP hydrolysis coupled proton transport	21873635.	IBA	Process
GO:0016020	membrane	1975705.	TAS	Component
GO:0016021	integral component of membrane	-	ISS	Component
GO:0016311	dephosphorylation	-	IEA	Process
GO:0016323	basolateral plasma membrane	-	IEA	Component
GO:0016324	apical plasma membrane	-	IEA	Component
GO:0016791	phosphatase activity	-	IEA	Function
GO:0019901	protein kinase binding	-	IEA	Function
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0030007	cellular potassium ion homeostasis	21873635.	IBA	Process
GO:0030007	cellular potassium ion homeostasis	10636900.19542013.	IDA	Process
GO:0030315	T-tubule	-	IEA	Component
GO:0030506	ankyrin binding	-	IEA	Function
GO:0030955	potassium ion binding	-	ISS	Function
GO:0031402	sodium ion binding	-	ISS	Function
GO:0031947	negative regulation of glucocorticoid biosynthetic process	-	IEA	Process
GO:0032991	protein-containing complex	22797923.	IDA	Component
GO:0034220	ion transmembrane transport	-	TAS	Process
GO:0036376	sodium ion export across plasma membrane	21873635.	IBA	Process
GO:0036376	sodium ion export across plasma membrane	10636900.19542013.	IDA	Process
GO:0036376	sodium ion export across plasma membrane	-	ISS	Process
GO:0042383	sarcolemma	-	ISS	Component
GO:0042470	melanosome	-	IEA	Component
GO:0042493	response to drug	-	IEA	Process
GO:0043531	ADP binding	-	IEA	Function
GO:0043548	phosphatidylinositol 3-kinase binding	-	IEA	Function
GO:0045822	negative regulation of heart contraction	-	IEA	Process
GO:0045823	positive regulation of heart contraction	-	IEA	Process
GO:0045989	positive regulation of striated muscle contraction	-	IEA	Process
GO:0051087	chaperone binding	10636900.	IPI	Function
GO:0055119	relaxation of cardiac muscle	23224879.	TAS	Process
GO:0060081	membrane hyperpolarization	-	IEA	Process
GO:0070062	extracellular exosome	12519789.19199708.20458337.	HDA	Component
GO:0071260	cellular response to mechanical stimulus	-	IEA	Process
GO:0071383	cellular response to steroid hormone stimulus	11546672.	IDA	Process
GO:0086002	cardiac muscle cell action potential involved in contraction	23224879.	TAS	Process
GO:0086004	regulation of cardiac muscle cell contraction	-	IEA	Process
GO:0086009	membrane repolarization	19542013.	IDA	Process
GO:0086013	membrane repolarization during cardiac muscle cell action potential	19542013.	IC	Process
GO:0086064	cell communication by electrical coupling involved in cardiac conduction	19683723.	TAS	Process
GO:1903416	response to glycoside	11546672.	IDA	Process
GO:1903561	extracellular vesicle	24769233.	HDA	Component
GO:1903779	regulation of cardiac conduction	-	TAS	Process
GO:1990239	steroid hormone binding	14742675.	IDA	Function
GO:1990573	potassium ion import across plasma membrane	21873635.	IBA	Process
GO:1990573	potassium ion import across plasma membrane	10636900.19542013.	IDA	Process
GO:1990573	potassium ion import across plasma membrane	-	ISS	Process

EuRBPDB

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Eesembl ID

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.