EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19289498	Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer.	Mol Cell Biol	2009 May	Liu K	doi: 10.1128/MCB.01140-08
23819404	[Molecular basis of gynecological oncology - TopBP1 protein as the guardian of genome integrity].	Ginekol Pol	2013 May	Forma E	-
21108795	TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study.	J Negat Results Biomed	2010 Nov 25	Blaut MA	doi: 10.1186/1477-5751-9-9.
23277395	Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer.	Mol Biol Rep	2013 May	Forma E	doi: 10.1007/s11033-012-2424-z
25216549	TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases.	Mol Cancer	2014 Sep 12	Choi SH	doi: 10.1186/1476-4598-13-211.
22708334	[Molecular basis of gynecological oncology--TopBP1 protein and its participation in the transcription process].	Ginekol Pol	2012 May	Forma E	-
24346708	Topoisomerase IIβ binding protein 1 c.*229C>T (rs115160714) gene polymorphism and endometrial cancer risk.	Pathol Oncol Res	2014 Jul	Forma E	doi: 10.1007/s12253-013-9737-7
22544570	Expression of TopBP1 in hereditary breast cancer.	Mol Biol Rep	2012 Jul	Forma E	doi: 10.1007/s11033-012-1622-z
23908141	Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk.	Mol Carcinog	2013 Nov	Jang JH	doi: 10.1002/mc.22037
21930790	TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.	Mol Cell Biol	2011 Nov	Liu K	doi: 10.1128/MCB.05574-11
26503213	The c.*229C>T gene polymorphism in 3'UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma.	Tumour Biol	2016 Apr	Starska K	doi: 10.1007/s13277-015-4276-3
17448016	Aberrant expression of TopBP1 in breast cancer.	Histopathology	2007 Mar	Going JJ	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	133618205	Splice_Region	novel		0.27
BLCA	chr3	133644305	Missense_Mutation	novel	L521F	0.18
BLCA	chr3	133623137	Frame_Shift_Del	novel	*K1044Rfs12**	0.39
BLCA	chr3	133620311	Missense_Mutation	NA	Q1072P	0.63
BLCA	chr3	133617274	Missense_Mutation	novel	I1215M	0.24
BLCA	chr3	133655336	Missense_Mutation	novel	Q232H	0.36
BLCA	chr3	133617311	Missense_Mutation	rs200596956	G1203A	0.43
BLCA	chr3	133653348	Missense_Mutation	novel	D307N	0.2
BLCA	chr3	133644064	Missense_Mutation	NA	E602K	0.33
BLCA	chr3	133623093	Missense_Mutation	NA	G1059A	1
BLCA	chr3	133657835	Missense_Mutation	novel	V109E	0.29
BLCA	chr3	133657836	Missense_Mutation	novel	V109I	0.29
BLCA	chr3	133655333	Silent	NA	L233L	0.3
BLCA	chr3	133649391	Missense_Mutation	novel	S499F	0.23
BLCA	chr3	133640112	Missense_Mutation	novel	H694Y	0.29
BLCA	chr3	133611105	Missense_Mutation	novel	D1358N	0.08
BLCA	chr3	133644126	Missense_Mutation	NA	K581R	0.44
BRCA	chr3	133628586	Missense_Mutation	NA	Q890E	0.22
BRCA	chr3	133655358	Missense_Mutation	NA	H225R	0.37
BRCA	chr3	133620271	Silent	NA	V1085V	0.21
BRCA	chr3	133659129	Missense_Mutation	novel	E36Q	0.06
BRCA	chr3	133640009	Missense_Mutation	novel	G728E	0.43
BRCA	chr3	133616841	Missense_Mutation	novel	D1282H	0.05
BRCA	chr3	133618384	Missense_Mutation	NA	E1141Q	0.21
BRCA	chr3	133616904	Missense_Mutation	NA	H1261Y	0.16
BRCA	chr3	133611129	Missense_Mutation	NA	E1350Q	0.2
BRCA	chr3	133643237	Missense_Mutation	NA	E662Q	0.14
BRCA	chr3	133649871	Missense_Mutation	rs369433427	R388C	0.18
BRCA	chr3	133638045	Missense_Mutation	NA	N784S	0.1
BRCA	chr3	133653489	Missense_Mutation	NA	H260N	0.16
BRCA	chr3	133661046	Missense_Mutation	rs74738463	E28K	0.18
BRCA	chr3	133640093	Missense_Mutation	rs768252230	R700H	0.29
CESC	chr3	133628658	Missense_Mutation	novel	V866F	0.31
CESC	chr3	133624145	Missense_Mutation	NA	F945L	0.49
CESC	chr3	133628412	Silent	NA	K918K	0.36
CESC	chr3	133657839	Missense_Mutation	novel	D108H	0.27
CESC	chr3	133628468	Missense_Mutation	NA	E900K	0.07
CESC	chr3	133624132	Missense_Mutation	rs751387961	R950W	0.22
CESC	chr3	133661785	5'UTR	novel		0.45
CESC	chr3	133628595	Missense_Mutation	novel	A887S	0.27
CESC	chr3	133618161	Intron	novel		0.38
CESC	chr3	133608637	Missense_Mutation	NA	L1441F	0.18
CESC	chr3	133628369	Missense_Mutation	NA	D933N	0.12
CESC	chr3	133655299	Missense_Mutation	NA	E245K	0.29
COAD	chr3	133616887	Frame_Shift_Del	novel	*K1266Nfs10**	0.13
COAD	chr3	133624132	Missense_Mutation	rs751387961	R950W	0.15
COAD	chr3	133655328	Missense_Mutation	NA	M235R	0.12
COAD	chr3	133617210	Missense_Mutation	NA	I1237V	0.28
COAD	chr3	133653463	Frame_Shift_Del	NA	*F268Lfs53**	0.15
COAD	chr3	133628672	Missense_Mutation	rs201984734	T861M	0.29
COAD	chr3	133649942	Missense_Mutation	NA	I364T	0.14
COAD	chr3	133661056	Frame_Shift_Del	rs142462088	*F24Lfs7**	0.38
COAD	chr3	133643251	Missense_Mutation	NA	A657G	0.19
COAD	chr3	133643280	Missense_Mutation	novel	E647D	0.06
COAD	chr3	133649546	Silent	rs113728030	Y447Y	0.48
COAD	chr3	133601267	Nonsense_Mutation	NA	R1518*	0.05
COAD	chr3	133659040	Silent	rs61747713	G65G	0.13
COAD	chr3	133624129	Missense_Mutation	NA	P951S	0.19
COAD	chr3	133616905	Silent	novel	T1260T	0.16
COAD	chr3	133649848	Missense_Mutation	NA	D395E	0.21
COAD	chr3	133624090	Frame_Shift_Del	novel	*R964Efs12**	0.19
COAD	chr3	133661056	Frame_Shift_Del	rs142462088	*F24Lfs7**	0.1
COAD	chr3	133643346	Missense_Mutation	NA	L625F	0.28
COAD	chr3	133611043	Frame_Shift_Ins	novel	*R1378Sfs18**	0.04
ESCA	chr3	133661056	Frame_Shift_Del	rs142462088	*F24Lfs7**	0.47
ESCA	chr3	133612478	Missense_Mutation	novel	E1316K	0.24
ESCA	chr3	133601310	Missense_Mutation	novel	L1503F	0.24
ESCA	chr3	133659041	Missense_Mutation	novel	G65V	0.24
ESCA	chr3	133611128	Missense_Mutation	novel	E1350G	0.11
ESCA	chr3	133601247	3'UTR	rs555920620		0.19
GBM	chr3	133620180	Nonsense_Mutation	novel	R1116*	0.34
GBM	chr3	133638065	Silent	rs749202540	V777V	0.22
GBM	chr3	133655431	Missense_Mutation	rs374437816	L201F	0.73
GBM	chr3	133649381	Splice_Site	novel	X502_splice	0.33
HNSC	chr3	133649523	Nonsense_Mutation	novel	S455*	0.21
HNSC	chr3	133628575	Silent	novel	E893E	0.43
HNSC	chr3	133653517	Silent	novel	K250K	0.19
HNSC	chr3	133640012	Missense_Mutation	rs759938150	T727M	0.21
HNSC	chr3	133643315	Missense_Mutation	novel	P636A	0.24
HNSC	chr3	133608568	Missense_Mutation	novel	L1464F	0.07
HNSC	chr3	133649536	Missense_Mutation	novel	E451K	0.34
HNSC	chr3	133628468	Missense_Mutation	novel	E900Q	0.08
HNSC	chr3	133649882	Missense_Mutation	novel	G384A	0.37
KIRC	chr3	133611071	Missense_Mutation	NA	R1369I	0.09
KIRC	chr3	133623163	Missense_Mutation	NA	V1036I	0.39
KIRP	chr3	133611050	Frame_Shift_Ins	novel	*R1376Kfs67**	0.37
KIRP	chr3	133612545	Silent	NA	L1293L	0.4
LAML	chr3	133624054	Missense_Mutation	novel	D976N	0.18
LAML	chr3	133608554	Missense_Mutation	novel	I1469N	0.05
LGG	chr3	133611036	Frame_Shift_Del	NA	*I1381Sfs61**	0.09
LGG	chr3	133644153	Missense_Mutation	novel	A572V	0.33
LIHC	chr3	133653424	Missense_Mutation	rs572308153	I281M	0.38
LIHC	chr3	133620182	Missense_Mutation	NA	G1115V	0.38
LUAD	chr3	133649419	Silent	NA	L490L	0.25
LUAD	chr3	133601197	3'UTR	novel		0.19
LUAD	chr3	133640002	Missense_Mutation	NA	R730S	0.35
LUAD	chr3	133608598	Silent	novel	A1454A	0.19
LUAD	chr3	133624145	Silent	novel	F945F	0.14
LUAD	chr3	133611006	Missense_Mutation	novel	E1391K	0.16
LUAD	chr3	133644212	Silent	novel	L552L	0.19
LUAD	chr3	133649437	Nonsense_Mutation	novel	E484*	0.15
LUAD	chr3	133652626	Missense_Mutation	NA	R309P	0.21
LUAD	chr3	133644096	Missense_Mutation	rs774702840	A591V	0.16
LUAD	chr3	133649814	Missense_Mutation	novel	E407K	0.14
LUAD	chr3	133644241	Missense_Mutation	NA	D543N	0.16
LUSC	chr3	133655345	Nonsense_Mutation	novel	Y229*	0.16
LUSC	chr3	133616926	Splice_Site	NA	X1254_splice	0.56
LUSC	chr3	133649631	Missense_Mutation	novel	P419H	0.22
LUSC	chr3	133623364	Missense_Mutation	rs369186269	R1008W	0.12
LUSC	chr3	133618315	Missense_Mutation	NA	P1164A	0.27
LUSC	chr3	133620319	Silent	novel	E1069E	0.1
LUSC	chr3	133637900	Silent	novel	L832L	0.17
LUSC	chr3	133656695	Missense_Mutation	novel	W176R	0.16
LUSC	chr3	133652621	Missense_Mutation	NA	L311F	0.36
LUSC	chr3	133620299	Missense_Mutation	NA	Q1076L	0.1
LUSC	chr3	133652631	Splice_Site	NA	X308_splice	0.33
LUSC	chr3	133608884	Missense_Mutation	novel	G1418R	0.27
LUSC	chr3	133608655	Silent	NA	T1435T	0.15
LUSC	chr3	133611036	Frame_Shift_Del	NA	*I1381Sfs61**	0.07
OV	chr3	133649592	In_Frame_Ins	novel	S432delinsMSLLLKPC	0.03
OV	chr3	133618146	Intron	novel		0.09
OV	chr3	133649871	Frame_Shift_Del	NA	*R388Vfs5**	0.21
OV	chr3	133637925	Missense_Mutation	novel	S824L	0.07
OV	chr3	133640025	Missense_Mutation	NA	E723Q	0.26
OV	chr3	133618146	Intron	novel		0.05
OV	chr3	133644058	Missense_Mutation	NA	E604K	0.32
OV	chr3	133618146	Intron	novel		0.1
PAAD	chr3	133601353	Missense_Mutation	novel	A1489V	0.26
PAAD	chr3	133618373	Silent	novel	I1144I	0.21
PAAD	chr3	133623130	Missense_Mutation	novel	A1047T	0.11
PAAD	chr3	133656719	Missense_Mutation	novel	L168I	0.19
PAAD	chr3	133608893	Missense_Mutation	novel	L1415F	0.31
PRAD	chr3	133624082	Silent	NA	V966V	0.34
PRAD	chr3	133637904	Missense_Mutation	novel	K831R	0.4
READ	chr3	133652465	Missense_Mutation	rs770675095	R363W	0.26
READ	chr3	133623353	Missense_Mutation	novel	N1011K	0.04
READ	chr3	133616874	Nonsense_Mutation	NA	Q1271*	0.42
READ	chr3	133655429	Frame_Shift_Del	NA	*F200Lfs4**	0.25
READ	chr3	133644155	Silent	rs746013675	I571I	0.38
READ	chr3	133649871	Missense_Mutation	rs369433427	R388C	0.42
SARC	chr3	133611075	Missense_Mutation	novel	R1368G	0.17
SARC	chr3	133624099	Missense_Mutation	novel	V961I	0.37
SARC	chr3	133617241	Missense_Mutation	novel	S1226R	0.09
SARC	chr3	133644338	Missense_Mutation	novel	R510S	0.09
SKCM	chr3	133644187	Missense_Mutation	novel	L561V	0.07
SKCM	chr3	133655309	Frame_Shift_Ins	novel	*I242Pfs22**	0.23
SKCM	chr3	133655311	In_Frame_Del	novel	H240del	0.23
SKCM	chr3	133618376	Silent	novel	I1143I	0.17
SKCM	chr3	133628457	Missense_Mutation	NA	K903N	0.75
SKCM	chr3	133643332	Missense_Mutation	rs764317613	S630L	0.17
SKCM	chr3	133655442	Missense_Mutation	NA	C197Y	0.26
SKCM	chr3	133612395	Silent	rs370706726	F1343F	0.34
SKCM	chr3	133611009	Missense_Mutation	NA	V1390F	0.07
SKCM	chr3	133653475	Silent	NA	T264T	0.62
SKCM	chr3	133601347	Missense_Mutation	novel	S1491L	0.33
SKCM	chr3	133617172	Silent	NA	H1249H	0.2
STAD	chr3	133661103	Missense_Mutation	NA	F9V	0.45
STAD	chr3	133652580	Silent	rs748945735	C324C	0.35
STAD	chr3	133640059	Nonsense_Mutation	rs770032653	W711*	0.13
STAD	chr3	133659040	Silent	rs61747713	G65G	0.67
STAD	chr3	133608557	Missense_Mutation	NA	Y1468C	0.15
STAD	chr3	133611036	Frame_Shift_Del	NA	*I1381Sfs61**	0.28
STAD	chr3	133611036	Frame_Shift_Del	NA	*I1381Sfs61**	0.12
STAD	chr3	133656825	Silent	NA	G132G	0.3
STAD	chr3	133611036	Frame_Shift_Del	NA	*I1381Sfs61**	0.39
STAD	chr3	133601267	Nonsense_Mutation	NA	R1518*	0.25
STAD	chr3	133620245	Missense_Mutation	NA	L1094P	0.15
STAD	chr3	133623141	Missense_Mutation	novel	N1043S	0.16
STAD	chr3	133640111	Missense_Mutation	NA	H694R	0.32
STAD	chr3	133618344	Missense_Mutation	novel	R1154T	0.11
STAD	chr3	133616887	Frame_Shift_Del	novel	*K1266Nfs10**	0.5
STAD	chr3	133616887	Frame_Shift_Del	novel	*K1266Nfs10**	0.21
STAD	chr3	133655431	Missense_Mutation	NA	L201V	0.08
STAD	chr3	133637990	Silent	NA	V802V	0.21
STAD	chr3	133640089	Silent	NA	G701G	0.21
STAD	chr3	133620189	Missense_Mutation	rs751699737	R1113C	0.32
STAD	chr3	133653517	Missense_Mutation	NA	K250N	0.16
STAD	chr3	133628672	Missense_Mutation	rs201984734	T861M	0.24
STAD	chr3	133640048	Missense_Mutation	NA	A715V	0.2
STAD	chr3	133656825	Silent	NA	G132G	0.11
THCA	chr3	133655450	Frame_Shift_Ins	novel	*D194Efs33**	0.07
THCA	chr3	133611052	Missense_Mutation	rs773108069	M1375I	0.04
UCEC	chr3	133656806	Missense_Mutation	NA	L139V	0.05
UCEC	chr3	133624112	Silent	NA	R956R	0.24
UCEC	chr3	133649871	Missense_Mutation	rs369433427	R388C	0.29
UCEC	chr3	133624076	Missense_Mutation	NA	I968M	0.28
UCEC	chr3	133638159	Missense_Mutation	novel	R746Q	0.04
UCEC	chr3	133652525	Missense_Mutation	NA	N343H	0.21
UCEC	chr3	133611075	Nonsense_Mutation	novel	R1368*	0.32
UCEC	chr3	133638091	Missense_Mutation	rs772205449	R769C	0.51
UCEC	chr3	133644189	Missense_Mutation	novel	V560A	0.36
UCEC	chr3	133649481	Missense_Mutation	novel	N469T	0.38
UCEC	chr3	133649873	Missense_Mutation	novel	V387A	0.21
UCEC	chr3	133608580	Silent	rs779005084	N1460N	0.61
UCEC	chr3	133618410	Missense_Mutation	NA	D1132G	0.2
UCEC	chr3	133659090	Missense_Mutation	NA	K49E	0.41
UCEC	chr3	133616853	Missense_Mutation	novel	Q1278E	0.2
UCEC	chr3	133624114	Missense_Mutation	novel	R956W	0.32
UCEC	chr3	133637945	Silent	rs746033534	S817S	0.37
UCEC	chr3	133661109	Nonsense_Mutation	novel	E7*	0.06
UCEC	chr3	133649786	Missense_Mutation	NA	A416V	0.26
UCEC	chr3	133638045	Missense_Mutation	NA	N784S	0.03
UCEC	chr3	133623359	Silent	novel	L1009L	0.16
UCEC	chr3	133638103	Missense_Mutation	novel	H765Y	0.05
UCEC	chr3	133600615	3'UTR	novel		0.52
UCEC	chr3	133628645	Missense_Mutation	novel	N870T	0.1
UCEC	chr3	133640097	Nonsense_Mutation	novel	E699*	0.14
UCEC	chr3	133620239	Missense_Mutation	novel	R1096I	0.37
UCEC	chr3	133640108	Missense_Mutation	novel	L695R	0.09
UCEC	chr3	133628590	Silent	novel	S888S	0.4
UCEC	chr3	133653526	Splice_Site	novel	X248_splice	0.3
UCEC	chr3	133618376	Silent	novel	I1143I	0.48
UCEC	chr3	133612484	Nonsense_Mutation	NA	R1314*	0.23
UCEC	chr3	133655431	Missense_Mutation	novel	L201I	0.21
UCEC	chr3	133612515	Silent	novel	T1303T	0.32
UCEC	chr3	133617175	Silent	rs375533520	P1248P	0.56
UCEC	chr3	133628463	Silent	novel	A901A	0.42
UCEC	chr3	133616887	Frame_Shift_Del	novel	*K1266Nfs10**	0.32
UCEC	chr3	133612395	Silent	rs370706726	F1343F	0.45
UCEC	chr3	133637889	Missense_Mutation	novel	S836Y	0.51
UCEC	chr3	133657931	Missense_Mutation	novel	R77I	0.47
UCEC	chr3	133659136	Missense_Mutation	novel	F33L	0.48
UCEC	chr3	133608651	Missense_Mutation	novel	L1437I	0.43
UCEC	chr3	133628616	Nonsense_Mutation	NA	R880*	0.56
UCEC	chr3	133652631	Splice_Site	NA	X308_splice	0.35
UCEC	chr3	133657908	Missense_Mutation	NA	I85V	0.5
UCEC	chr3	133611075	Nonsense_Mutation	novel	R1368*	0.45
UCEC	chr3	133611035	Frame_Shift_Ins	NA	*I1381Nfs11**	0.34
UCEC	chr3	133618281	Missense_Mutation	NA	V1175A	0.37
UCEC	chr3	133652523	Frame_Shift_Ins	novel	*N343Kfs14**	0.38
UCEC	chr3	133618415	Silent	novel	V1130V	0.42
UCEC	chr3	133611076	Silent	rs779755916	Q1367Q	0.16
UCEC	chr3	133617175	Silent	rs375533520	P1248P	0.23
UCEC	chr3	133661089	Missense_Mutation	rs763367222	F13L	0.17
UCEC	chr3	133601192	3'UTR	novel		0.52
UCEC	chr3	133659058	Silent	novel	I59I	0.4
UCEC	chr3	133638127	Missense_Mutation	NA	N757D	0.35
UCEC	chr3	133639957	Splice_Site	novel	X745_splice	0.52
UCEC	chr3	133652465	Missense_Mutation	rs770675095	R363W	0.37
UCEC	chr3	133644149	Silent	novel	N573N	0.41
UCEC	chr3	133601074	3'UTR	novel		0.26
UCEC	chr3	133638065	Silent	rs749202540	V777V	0.26
UCEC	chr3	133657800	Frame_Shift_Del	novel	*R121Gfs10**	0.15
UCEC	chr3	133600621	3'UTR	novel		0.15
UCEC	chr3	133628678	Missense_Mutation	rs749948531	P859L	0.32
UCEC	chr3	133640012	Missense_Mutation	rs759938150	T727M	0.35
UCEC	chr3	133659058	Silent	novel	I59I	0.22
UCEC	chr3	133608580	Silent	rs779005084	N1460N	0.34
UCEC	chr3	133644351	Missense_Mutation	rs200974032	T506M	0.48
UCEC	chr3	133661104	Silent	novel	P8P	0.38
UCEC	chr3	133644299	Missense_Mutation	novel	D523E	0.22
UCEC	chr3	133656755	Frame_Shift_Ins	novel	*Y156Ifs31**	0.39
UCEC	chr3	133623364	Missense_Mutation	rs369186269	R1008W	0.31
UCEC	chr3	133652464	Missense_Mutation	novel	R363Q	0.43
UCEC	chr3	133611022	Missense_Mutation	NA	Q1385H	0.3
UCEC	chr3	133612484	Nonsense_Mutation	NA	R1314*	0.32
UCEC	chr3	133616893	Nonsense_Mutation	novel	*L1264Ffs4**	0.05
UCEC	chr3	133612484	Nonsense_Mutation	NA	R1314*	0.29
UCEC	chr3	133601070	3'UTR	novel		0.29
UCEC	chr3	133628434	Missense_Mutation	novel	C911Y	0.27
UCEC	chr3	133643235	Missense_Mutation	novel	E662D	0.22
UCEC	chr3	133644285	Missense_Mutation	novel	S528Y	0.46
UCEC	chr3	133649554	Missense_Mutation	novel	A445T	0.19
UCEC	chr3	133652579	Missense_Mutation	rs199552139	V325I	0.34
UCEC	chr3	133653371	Missense_Mutation	novel	P299H	0.23
UCEC	chr3	133657799	Missense_Mutation	rs778316444	R121K	0.2
UCEC	chr3	133628421	Frame_Shift_Del	novel	*K915Nfs9**	0.23
UCEC	chr3	133628609	Missense_Mutation	NA	A882D	0.25
UCEC	chr3	133628388	Silent	rs375620402	I926I	0.33
UCEC	chr3	133628573	Missense_Mutation	novel	A894V	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.1591	0.11092
LGG	DEL	0.0526	0.04374

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0021	Kaplan-Meier Survival Analysis
SARC	0.012	Kaplan-Meier Survival Analysis
MESO	0.017	Kaplan-Meier Survival Analysis
ACC	0.0018	Kaplan-Meier Survival Analysis
UCS	0.035	Kaplan-Meier Survival Analysis
SKCM	0.0014	Kaplan-Meier Survival Analysis
PRAD	0.011	Kaplan-Meier Survival Analysis
KIRP	0.0064	Kaplan-Meier Survival Analysis
PAAD	0.00031	Kaplan-Meier Survival Analysis
PCPG	0.013	Kaplan-Meier Survival Analysis
READ	0.013	Kaplan-Meier Survival Analysis
KICH	0.0035	Kaplan-Meier Survival Analysis
UCEC	0.00012	Kaplan-Meier Survival Analysis
LIHC	0.00046	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000163781 (Gene tree)
Gene ID: 11073
Gene Symbol: TOPBP1
Alias: KIAA0259|TOP2BP1|Dpb11
Full Name: DNA topoisomerase II binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 64,206 bases
Position: chr3:133,598,175-133,662,380
Accession: 17008
RBP type: non-canonical RBP
Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000260810	TOPBP1-201	5378	XM_011512357	ENSP00000260810	1522 (aa)	XP_011510659	Q92547
ENST00000642236	TOPBP1-210	6152	XM_005247076	ENSP00000493612	1517 (aa)	XP_005247133	A0A2R8YD63
ENST00000513818	TOPBP1-208	898	-	-	- (aa)	-	-
ENST00000511439	TOPBP1-207	1142	-	-	- (aa)	-	-
ENST00000503338	TOPBP1-202	618	-	-	- (aa)	-	-
ENST00000509162	TOPBP1-206	811	-	-	- (aa)	-	-
ENST00000503464	TOPBP1-203	525	-	-	- (aa)	-	-
ENST00000572787	TOPBP1-209	402	-	ENSP00000458790	50 (aa)	-	I3L1F2
ENST00000505804	TOPBP1-204	472	-	-	- (aa)	-	-
ENST00000506779	TOPBP1-205	536	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000163781's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03440	Homologous recombination	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163781	Platelet Function Tests	9.0000000E-007	-
ENSG00000163781	Platelet Function Tests	2.7300000E-006	-
ENSG00000163781	Platelet Function Tests	1.9400000E-006	-
ENSG00000163781	Iron	1E-6	19084217

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163781's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000794	condensed nuclear chromosome	-	IEA	Component
GO:0000922	spindle pole	-	IEA	Component
GO:0001673	male germ cell nucleus	-	IEA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0005515	protein binding	12773567.17006541.17887956.17913746.18923429.20080954.21659603.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	21659603.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0005815	microtubule organizing center	-	IEA	Component
GO:0006259	DNA metabolic process	9461304.	TAS	Process
GO:0006260	DNA replication	-	TAS	Process
GO:0006281	DNA repair	12773567.	NAS	Process
GO:0006974	cellular response to DNA damage stimulus	12773567.	IDA	Process
GO:0008022	protein C-terminus binding	9461304.	TAS	Function
GO:0010212	response to ionizing radiation	12773567.	IDA	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0016605	PML body	12773567.	IDA	Component
GO:0033314	mitotic DNA replication checkpoint	21873635.	IBA	Process
GO:0042802	identical protein binding	17006541.	IPI	Function
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.