EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25407051Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer.J Transl Med2014 Nov 19Xiang Jdoi: 10.1186/s12967-014-0320-0.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr3186790225Missense_MutationnovelQ305E0.06
BLCAchr3186790246Missense_MutationnovelD298H0.17
BLCAchr3186794664Missense_Mutationrs764526307R135H0.18
BLCAchr3186792888Missense_MutationNAS157L0.12
BLCAchr3186794734Missense_MutationNAD112N0.14
BLCAchr3186789976Missense_MutationnovelN362S0.25
BLCAchr3186791704Intronnovel0.55
BLCAchr3186790014Silentrs754962980I349I0.13
BLCAchr3186790179Missense_MutationnovelS320F0.38
BLCAchr3186790354Missense_MutationnovelS285C0.35
BRCAchr3186801124Missense_MutationNAG68A0.37
BRCAchr3186790329Silentrs200590902V293V0.22
BRCAchr3186790157SilentNAI327I0.17
BRCAchr3186790110Splice_SitenovelX332_splice0.11
BRCAchr3186789978SilentNAQ361Q0.31
BRCAchr3186790155Frame_Shift_DelNAT328Kfs*110.25
BRCAchr3186790157In_Frame_DelnovelS325_I327del0.23
CESCchr3186790064Splice_SitenovelX333_splice0.13
CESCchr3186791712Intronnovel0.35
COADchr3186794763Missense_Mutationrs777641769R102Q0.3
COADchr3186790256Splice_SiteNAX295_splice0.28
COADchr3186794694Missense_MutationNAN125T0.4
COADchr3186804618Frame_Shift_InsNAN32Kfs*200.29
COADchr3186790255Missense_MutationNAD295H0.2
COADchr3186792933Missense_MutationNAP142L0.29
COADchr3186789987Frame_Shift_InsNAL359Vfs*80.39
COADchr3186797605Missense_MutationNAL74I0.17
DLBCchr3186790159Missense_MutationNAI327V0.09
GBMchr3186792524Missense_MutationnovelI214T0.55
GBMchr3186792886Missense_MutationnovelA158T0.34
GBMchr3186790382In_Frame_Delrs769831210D275del0.3
HNSCchr3186801138Missense_MutationNAK63N0.19
HNSCchr3186794689Frame_Shift_DelnovelA127Lfs*30.11
HNSCchr31867899583'UTRnovel0.44
HNSCchr3186790208SilentnovelL310L0.38
KIRCchr3186790384Missense_MutationNAD275G0.1
KIRCchr3186790362SilentNAQ282Q0.09
KIRPchr3186790384Missense_MutationNAD275V0.26
LAMLchr3186790139Splice_Regionrs7540466130.26
LGGchr3186791769Missense_MutationnovelG253C0.25
LGGchr3186791830Frame_Shift_DelnovelK232Sfs*400.12
LUADchr3186797555SilentNAA90A0.13
LUADchr3186790141Splice_Siters370046824X332_splice0.69
LUADchr3186792522Missense_MutationNAA215T0.2
LUADchr3186790176Nonsense_MutationnovelD321Vfs*20.13
LUADchr3186790164Missense_MutationnovelS325C0.16
LUADchr3186794710Nonsense_MutationNAR120*0.2
LUADchr3186790381Missense_MutationNAG276V0.31
LUADchr3186804664Missense_MutationNAT17S0.75
LUSCchr31867899463'UTRrs20665020.25
LUSCchr3186790391Missense_MutationNAK273E0.18
LUSCchr3186792523SilentnovelI214I0.04
LUSCchr3186792587Missense_MutationNAR193I0.3
LUSCchr3186790017SilentnovelL348L0.16
LUSCchr3186804673Missense_Mutationrs773156360P14L0.4
LUSCchr3186790208SilentnovelL310L0.29
LUSCchr3186794661Nonsense_MutationNAS136*0.05
LUSCchr3186791704Intronnovel0.23
LUSCchr3186790381Missense_MutationNAG276A0.11
LUSCchr3186801191Missense_MutationnovelP46T0.44
LUSCchr31868047215'UTRnovel0.26
MESOchr3186790381Frame_Shift_InsnovelG276Efs*120.37
OVchr3186794724Nonsense_MutationnovelG115Vfs*20.11
OVchr3186792882Frame_Shift_InsnovelA159Vfs*320.08
OVchr3186804623Nonsense_MutationnovelE31*0.07
PAADchr3186801162SilentnovelQ55Q0.17
PRADchr31868047145'UTRnovel0.05
READchr3186790017SilentNAL348L0.67
SKCMchr3186792827SilentnovelC177C0.29
SKCMchr3186790063Missense_MutationnovelE333G0.19
SKCMchr3186804672SilentnovelP14P0.31
SKCMchr3186789982Missense_MutationnovelS360Y0.53
SKCMchr3186791743SilentNAV261V0.19
SKCMchr3186797570SilentNAT85T0.29
STADchr3186791832Missense_MutationNAK232E0.05
STADchr3186804641Missense_MutationnovelS25G0.07
UCECchr31867899203'UTRnovel0.53
UCECchr3186790057Missense_MutationNAD335G0.51
UCECchr3186794705Missense_MutationnovelE121D0.37
UCECchr3186791783Missense_MutationnovelA248D0.38
UCECchr3186794693Missense_MutationnovelN125K0.38
UCECchr3186792897Missense_MutationnovelS154C0.12
UCECchr3186791727Missense_MutationnovelG267R0.05
UCECchr3186794758Missense_MutationnovelR104G0.06
UCECchr3186791679Intronnovel0.35
UCECchr3186792546Missense_MutationNAQ207E0.56
UCECchr3186791793Missense_MutationnovelL245V0.05
UCECchr3186791804Missense_MutationnovelA241V0.39
UCECchr3186792939Missense_Mutationrs560784172P140L0.31
UCECchr3186794752Missense_MutationnovelL106I0.35
UCECchr3186790220Silentrs531700146L306L0.33
UCECchr3186791793Missense_MutationnovelL245I0.42
UCECchr3186794695Missense_MutationnovelN125H0.28
UCECchr3186801193Missense_MutationnovelR45H0.32
UCECchr3186801136Missense_MutationnovelK64T0.12
UCECchr3186792573Missense_Mutationrs765207894R198C0.38
UCECchr3186791786Missense_MutationnovelS247N0.09
UCECchr3186792845Silentrs201652361S171S0.34
UCECchr3186790142Splice_RegionnovelA332A0.19
UCECchr3186790248Missense_MutationnovelI297K0.4
UCECchr31867899363'UTRrs7650806730.61
UCECchr3186790157SilentNAI327I0.51
UCECchr3186804611Missense_MutationNAA35T0.19
UCECchr3186801134Frame_Shift_Insrs776828891S65Ifs*90.41
UCECchr3186790017SilentNAL348L0.13
UCSchr3186792585Missense_MutationnovelC194R0.08

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.43870.0018563
KIRCAMP0.11932.0306e-05
KIRPAMP0.31940.15981
LUADDEL0.18410.010111
PAADAMP0.10330.16151
SARCDEL0.15560.0086757
TGCTAMP0.25337.0307e-05

Survival Analysis
CancerP-value Q-value
KIRC0.00013

Kaplan-Meier Survival Analysis

STAD0.022

Kaplan-Meier Survival Analysis

MESO0.0031

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

SKCM0.042

Kaplan-Meier Survival Analysis

PRAD0.041

Kaplan-Meier Survival Analysis

LUSC0.017

Kaplan-Meier Survival Analysis

KIRP0.001

Kaplan-Meier Survival Analysis

PAAD0.0011

Kaplan-Meier Survival Analysis

PCPG0.02

Kaplan-Meier Survival Analysis

CESC0.00065

Kaplan-Meier Survival Analysis

KICH0.0024

Kaplan-Meier Survival Analysis

UCEC0.00014

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.0073

Kaplan-Meier Survival Analysis

LGG0.0032

Kaplan-Meier Survival Analysis

LUAD0.0038

Kaplan-Meier Survival Analysis

UVM0.041

Kaplan-Meier Survival Analysis

OV0.0087

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000163918 (Gene tree)
Gene ID
5984
Gene Symbol
RFC4
Alias
A1|RFC37
Full Name
replication factor C subunit 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
17,179 bases
Position
chr3:186,789,880-186,807,058
Accession
9972
RBP type
non-canonical RBP
Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000494047RFC4-2141393--- (aa)--
ENST00000411792RFC4-203560-ENSP0000039931443 (aa)-C9JW34
ENST00000489028RFC4-213533--- (aa)--
ENST00000449502RFC4-210799-ENSP0000039487097 (aa)-F8WE44
ENST00000296273RFC4-2011384-ENSP00000296273363 (aa)-P35249
ENST00000448497RFC4-209453-ENSP0000041509995 (aa)-C9JGY5
ENST00000433496RFC4-2071111-ENSP00000399769336 (aa)-C9JZI1
ENST00000392481RFC4-2021448-ENSP00000376272363 (aa)-P35249
ENST00000418288RFC4-205701-ENSP00000411300214 (aa)-C9J8M3
ENST00000460408RFC4-211628--- (aa)--
ENST00000427785RFC4-206485-ENSP00000407982123 (aa)-C9JXZ7
ENST00000479307RFC4-2121043--- (aa)--
ENST00000417876RFC4-204479-ENSP00000401429111 (aa)-H7C1P0
ENST00000447345RFC4-208785-ENSP00000413065167 (aa)-C9JTT7
Gene Model
Click here to download ENSG00000163918's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
hsa03420Nucleotide excision repairKEGG
hsa03430Mismatch repairKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000163918Adiponectin1E-1920876611
ENSG00000163918Adiponectin2E-2224105470
ENSG00000163918Adiponectin4E-726299439
ENSG00000163918Adiponectin8E-626299439
ENSG00000163918Adiponectin3E-1220011104
ENSG00000163918Adiponectin2E-4222479202
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163918's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003689DNA clamp loader activity21873635.IBAFunction
GO:0003689DNA clamp loader activity12930902.IDAFunction
GO:0005515protein binding9488738.15655353.16189514.21516116.23277426.25416956.30021884.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005663DNA replication factor C complex21873635.IBAComponent
GO:0005663DNA replication factor C complex9488738.IDAComponent
GO:0006260DNA replication-TASProcess
GO:0006261DNA-dependent DNA replication21873635.IBAProcess
GO:0006271DNA strand elongation involved in DNA replication7774928.TASProcess
GO:0006283transcription-coupled nucleotide-excision repair-TASProcess
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TASProcess
GO:0006297nucleotide-excision repair, DNA gap filling-TASProcess
GO:0019899enzyme binding-IEAFunction
GO:0019985translesion synthesis-TASProcess
GO:0031390Ctf18 RFC-like complex12930902.IDAComponent
GO:0031391Elg1 RFC-like complex23277426.IDAComponent
GO:0032201telomere maintenance via semi-conservative replication-TASProcess
GO:0033683nucleotide-excision repair, DNA incision-TASProcess
GO:0042276error-prone translesion synthesis-TASProcess
GO:0042769DNA damage response, detection of DNA damage-TASProcess
GO:0043142single-stranded DNA-dependent ATPase activity12930902.IDAFunction
GO:0070987error-free translesion synthesis-TASProcess
GO:1900264positive regulation of DNA-directed DNA polymerase activity12930902.IDAProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
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