EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24452241	RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors.	RNA Biol	2014	Wong QW	doi: 10.4161/rna.27427
24815453	Effects of ribosomal protein l39-L on the drug resistance mechanisms of lung cancer A549 cells.	Asian Pac J Cancer Prev	2014	Liu HS	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	187121031	3'UTR	novel		0.44
BRCA	chr3	187120988	3'UTR	novel		0.75
BRCA	chr3	187121142	3'UTR	novel		0.12
BRCA	chr3	187121150	Missense_Mutation	NA	L51V	0.23
COAD	chr3	187121303	5'UTR	rs765412887		0.22
COAD	chr3	187121153	Missense_Mutation	NA	G50C	0.44
COAD	chr3	187121220	Silent	NA	I27I	0.28
ESCA	chr3	187121135	3'UTR	rs371711435		0.21
HNSC	chr3	187121278	Missense_Mutation	novel	T8S	0.32
HNSC	chr3	187121276	Missense_Mutation	novel	I9F	0.19	Ribosomal_L39
HNSC	chr3	187121209	Missense_Mutation	rs769500230	P31L	0.07	Ribosomal_L39
HNSC	chr3	187121210	Missense_Mutation	novel	P31S	0.07	Ribosomal_L39
LUAD	chr3	187121178	Silent	novel	R41R	0.12
LUSC	chr3	187121190	Nonsense_Mutation	novel	Y37*	0.19	Ribosomal_L39
LUSC	chr3	187121105	3'UTR	novel		0.22
OV	chr3	187121264	Frame_Shift_Del	novel	*L13Wfs17**	0.6	Ribosomal_L39
OV	chr3	187121300	Translation_Start_Site	rs762053308	M1?	0.11
SARC	chr3	187121144	3'UTR	novel		0.23
SKCM	chr3	187121240	Missense_Mutation	rs547833786	R21C	0.08	Ribosomal_L39
SKCM	chr3	187121119	3'UTR	novel		0.62
SKCM	chr3	187121231	Missense_Mutation	NA	P24S	0.49	Ribosomal_L39
SKCM	chr3	187121143	3'UTR	novel		0.33
STAD	chr3	187121085	3'UTR	novel		0.15
STAD	chr3	187121287	Missense_Mutation	NA	K5M	0.05
STAD	chr3	187121318	5'UTR	novel		0.34
UCEC	chr3	187121160	Silent	novel	T47T	0.12
UCEC	chr3	187121240	Missense_Mutation	rs547833786	R21C	0.32	Ribosomal_L39
UCEC	chr3	187121114	3'UTR	novel		0.52
UCEC	chr3	187121255	Missense_Mutation	novel	K16E	0.4	Ribosomal_L39
UCEC	chr3	187121085	3'UTR	novel		0.49
UCEC	chr3	187121203	Missense_Mutation	NA	S33N	0.1	Ribosomal_L39
UCEC	chr3	187121302	5'UTR	novel		0.6
UCEC	chr3	187121004	3'UTR	novel		0.47
UCEC	chr3	187121059	3'UTR	novel		0.3
UCEC	chr3	187121021	3'UTR	novel		0.63
UCEC	chr3	187121004	3'UTR	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4338	0.0018563
KIRC	AMP	0.1193	2.0306e-05
KIRP	AMP	0.3194	0.15981
LUAD	DEL	0.1919	0.010111
PAAD	AMP	0.1033	0.16151
SARC	DEL	0.1595	0.0086757
TGCT	AMP	0.2533	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
ACC	0.0023	Kaplan-Meier Survival Analysis
PAAD	0.0096	Kaplan-Meier Survival Analysis
LAML	0.01	Kaplan-Meier Survival Analysis
UCEC	0.0023	Kaplan-Meier Survival Analysis
GBM	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.033	Kaplan-Meier Survival Analysis
DLBC	0.01	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.0053	Kaplan-Meier Survival Analysis
LUAD	0.012	Kaplan-Meier Survival Analysis
UVM	0.04	Kaplan-Meier Survival Analysis
OV	0.00016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163923 (Gene tree)
Gene ID: 116832
Gene Symbol: RPL39L
Alias: RPL39L1
Full Name: ribosomal protein L39 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 59,961 bases
Position: chr3:187,120,948-187,180,908
Accession: 17094
RBP type: canonical RBP
Summary: This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000296277	Ribosomal_L39	PF00832.20	4.2e-22	1	1
ENSP00000389356	Ribosomal_L39	PF00832.20	4.2e-22	1	1
ENSP00000397240	Ribosomal_L39	PF00832.20	4.2e-22	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000296277	RPL39L-201	756	-	ENSP00000296277	51 (aa)	-	Q96EH5
ENST00000455270	RPL39L-203	653	-	ENSP00000397240	51 (aa)	-	Q96EH5
ENST00000433055	RPL39L-202	749	-	ENSP00000389356	51 (aa)	-	Q96EH5

Gene Model

Click here to download ENSG00000163923's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163923	rs16861629	3	187121427	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163923's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000163923	RPL39L	100	92.157	ENSG00000198918	RPL39	100	92.157

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163923	RPL39L	100	92.157	ENSCJAG00000042864	-	100	92.157	Callithrix_jacchus
ENSG00000163923	RPL39L	100	72.549	ENSCJAG00000045312	-	100	72.549	Callithrix_jacchus
ENSG00000163923	RPL39L	100	98.039	ENSCSAG00000018929	RPL39L	100	98.039	Chlorocebus_sabaeus
ENSG00000163923	RPL39L	100	98.039	ENSCANG00000015756	RPL39L	100	98.039	Colobus_angolensis_palliatus
ENSG00000163923	RPL39L	100	98.039	ENSGGOG00000039881	RPL39L	100	98.039	Gorilla_gorilla
ENSG00000163923	RPL39L	100	86.275	ENSGGOG00000037933	-	100	86.275	Gorilla_gorilla
ENSG00000163923	RPL39L	100	98.039	ENSMFAG00000012432	RPL39L	100	98.039	Macaca_fascicularis
ENSG00000163923	RPL39L	100	98.039	ENSMMUG00000045578	RPL39L	100	98.039	Macaca_mulatta
ENSG00000163923	RPL39L	100	98.039	ENSMNEG00000002491	RPL39L	100	98.039	Macaca_nemestrina
ENSG00000163923	RPL39L	100	98.039	ENSNLEG00000032768	RPL39L	100	98.039	Nomascus_leucogenys
ENSG00000163923	RPL39L	100	98.039	ENSPPAG00000001747	RPL39L	100	98.039	Pan_paniscus
ENSG00000163923	RPL39L	100	98.039	ENSPTRG00000052452	RPL39L	100	98.039	Pan_troglodytes
ENSG00000163923	RPL39L	100	96.078	ENSPPYG00000014389	RPL39L	100	96.078	Pongo_abelii
ENSG00000163923	RPL39L	100	98.039	ENSRBIG00000029733	RPL39L	100	98.039	Rhinopithecus_bieti
ENSG00000163923	RPL39L	100	98.039	ENSRROG00000016550	RPL39L	100	98.039	Rhinopithecus_roxellana

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	-	IEA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0006412	translation	-	IEA	Process
GO:0007283	spermatogenesis	12490704.	IEP	Process
GO:0022625	cytosolic large ribosomal subunit	21873635.	IBA	Component
GO:0022625	cytosolic large ribosomal subunit	12490704.	NAS	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.