EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23118983	A ??38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity.	PLoS One	2012	Schneider S	doi: 10.1371/journal.pone.0048321
26811478	Transketolase counteracts oxidative stress to drive cancer development.	Proc Natl Acad Sci U S A	2016 Feb 9	Xu IM	doi: 10.1073/pnas.1508779113
25895698	Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.	Clin Exp Metastasis	2015 Jun	Ricciardelli C	doi: 10.1007/s10585-015-9718-1

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	53234985	Splice_Region	rs140465934	F209F	0.44
ACC	chr3	53225735	Intron	rs2229693		0.9
BLCA	chr3	53229314	Missense_Mutation	novel	I410M	0.19
BLCA	chr3	53241185	Missense_Mutation	novel	E96K	0.3
BLCA	chr3	53235105	Silent	rs200456564	F169F	0.72
BLCA	chr3	53255953	5'UTR	novel		0.45
BLCA	chr3	53241162	Silent	novel	I103I	0.42
BRCA	chr3	53229342	Missense_Mutation	NA	R401H	0.16
BRCA	chr3	53235067	Missense_Mutation	NA	L182Q	0.47
BRCA	chr3	53226851	Missense_Mutation	novel	P534L	0.43
CESC	chr3	53241165	Missense_Mutation	novel	K102N	0.15
CESC	chr3	53228141	Silent	NA	L496L	0.51
CESC	chr3	53241147	Silent	rs530581442	D108D	0.41
COAD	chr3	53229305	Silent	rs150763423	C413C	0.33
COAD	chr3	53240282	Missense_Mutation	novel	A136T	0.27
COAD	chr3	53235115	Missense_Mutation	novel	A166V	0.22
COAD	chr3	53229284	Silent	NA	S420S	0.26
COAD	chr3	53242160	Frame_Shift_Del	NA	*R64Gfs35**	0.44
COAD	chr3	53255950	5'UTR	novel		0.16
COAD	chr3	53229335	Silent	rs144151385	A403A	0.06
COAD	chr3	53241221	Missense_Mutation	novel	A84T	0.47
COAD	chr3	53242217	Missense_Mutation	rs782597207	A45T	0.31
COAD	chr3	53226844	Silent	NA	T536T	0.35
COAD	chr3	53229305	Silent	rs150763423	C413C	0.42
COAD	chr3	53241133	Missense_Mutation	NA	P113L	0.47
COAD	chr3	53226809	Missense_Mutation	novel	S548N	0.04
ESCA	chr3	53230526	Silent	novel	T346T	0.75
GBM	chr3	53228351	Silent	novel	C468C	0.27
GBM	chr3	53226808	Missense_Mutation	novel	S548R	0.21
GBM	chr3	53235170	Nonsense_Mutation	novel	R148*	0.14
GBM	chr3	53225812	Missense_Mutation	novel	G606R	0.07
GBM	chr3	53226864	Missense_Mutation	rs782692158	R530C	0.11
HNSC	chr3	53226813	Missense_Mutation	rs148472107	D547N	0.11
HNSC	chr3	53229434	Splice_Region	novel	V370V	0.75
HNSC	chr3	53231485	Missense_Mutation	novel	Q272E	0.11
HNSC	chr3	53242144	Missense_Mutation	novel	D69G	0.25
HNSC	chr3	53226867	Missense_Mutation	rs782186345	I529V	0.22
KIRC	chr3	53228126	Missense_Mutation	NA	D501E	0.44
KIRP	chr3	53230611	Missense_Mutation	rs781935591	R318H	0.07
KIRP	chr3	53256013	5'Flank	novel		0.31
KIRP	chr3	53229097	Silent	novel	A435A	0.31
KIRP	chr3	53230578	Missense_Mutation	novel	G329D	0.57
LGG	chr3	53230598	Silent	novel	G322G	0.35
LGG	chr3	53240251	Missense_Mutation	novel	S146I	0.32
LIHC	chr3	53233192	Missense_Mutation	novel	I238V	0.42
LIHC	chr3	53229085	Silent	novel	S439S	0.21
LUAD	chr3	53228060	Missense_Mutation	novel	K523N	0.18
LUAD	chr3	53228083	Missense_Mutation	NA	L516M	0.36
LUAD	chr3	53230619	Frame_Shift_Del	novel	*I315Mfs56**	0.29
LUAD	chr3	53241219	Silent	rs11556006	A84A	0.3
LUSC	chr3	53241191	Nonsense_Mutation	NA	E94*	0.56
OV	chr3	53229031	Silent	novel	A457A	0.09
OV	chr3	53225775	Missense_Mutation	novel	G618A	0.16
OV	chr3	53231379	Missense_Mutation	novel	P307L	0.09
OV	chr3	53233197	Missense_Mutation	novel	T236I	0.22
OV	chr3	53235011	Missense_Mutation	novel	I201V	0.22
OV	chr3	53229029	Missense_Mutation	novel	V458E	0.13
OV	chr3	53240334	Silent	rs144750087	T118T	0.43
OV	chr3	53225874	In_Frame_Del	novel	V577_T585del	0.08
OV	chr3	53231355	Splice_Site	novel	X314_splice	0.05
PAAD	chr3	53231465	Silent	novel	I278I	0.19
PAAD	chr3	53231532	Missense_Mutation	NA	S256Y	0.16
PAAD	chr3	53255833	Splice_Region	novel		0.33
PCPG	chr3	53255985	5'UTR	novel		0.56
PRAD	chr3	53240254	Missense_Mutation	novel	A145V	0.08
SARC	chr3	53240282	Missense_Mutation	novel	A136P	0.2
SKCM	chr3	53225822	Silent	NA	L602L	0.31
SKCM	chr3	53229343	Missense_Mutation	rs369574554	R401C	0.27
SKCM	chr3	53231438	Silent	rs782201213	T287T	0.17
SKCM	chr3	53231439	Missense_Mutation	rs782350738	T287I	0.18
SKCM	chr3	53230492	Missense_Mutation	rs751068013	R358C	0.23
SKCM	chr3	53230498	Missense_Mutation	NA	P356S	0.27
SKCM	chr3	53241165	Missense_Mutation	novel	K102N	0.6
SKCM	chr3	53230556	Silent	rs145719162	I336I	0.34
SKCM	chr3	53229284	Silent	NA	S420S	0.16
SKCM	chr3	53226784	Silent	NA	I556I	0.49
SKCM	chr3	53241193	Missense_Mutation	rs782486373	A93V	0.15
SKCM	chr3	53231512	Missense_Mutation	NA	P263S	0.34
SKCM	chr3	53228332	Missense_Mutation	NA	P475S	0.32
STAD	chr3	53255870	Missense_Mutation	rs782431137	S25G	0.23
STAD	chr3	53231509	Missense_Mutation	rs782480479	K264Q	0.08
STAD	chr3	53231495	Silent	novel	E268E	0.47
STAD	chr3	53229018	Missense_Mutation	rs781856744	A462T	0.27
STAD	chr3	53240273	Missense_Mutation	rs782694913	G139S	0.2
STAD	chr3	53241186	Silent	rs140341715	A95A	0.14
STAD	chr3	53229278	Splice_Site	NA	X422_splice	0.21
TGCT	chr3	53230529	Silent	novel	S345S	0.06
THCA	chr3	53225676	Intron	novel		0.19
UCEC	chr3	53228090	Silent	novel	H513H	0.33
UCEC	chr3	53235085	Missense_Mutation	novel	D176G	0.09
UCEC	chr3	53225807	Silent	rs782791721	I607I	0.32
UCEC	chr3	53234985	Splice_Region	rs140465934	F209F	0.44
UCEC	chr3	53228090	Silent	novel	H513H	0.43
UCEC	chr3	53229048	Missense_Mutation	rs782226516	V452I	0.35
UCEC	chr3	53229334	Missense_Mutation	NA	A404T	0.51
UCEC	chr3	53225928	Missense_Mutation	NA	G567D	0.29
UCEC	chr3	53231532	Missense_Mutation	NA	S256Y	0.11
UCEC	chr3	53234994	Silent	rs201022137	C206C	0.09
UCEC	chr3	53231446	Missense_Mutation	novel	L285M	0.17
UCEC	chr3	53255975	5'UTR	novel		0.14
UCEC	chr3	53225720	Intron	novel		0.34
UCEC	chr3	53240331	Silent	novel	D119D	0.42
UCEC	chr3	53240262	Silent	rs139845255	F142F	0.18
UCEC	chr3	53229333	Missense_Mutation	novel	A404V	0.35
UCEC	chr3	53229426	Missense_Mutation	rs139724440	A373V	0.26
UCEC	chr3	53226816	Missense_Mutation	rs782581923	L546F	0.44
UCEC	chr3	53229135	Nonsense_Mutation	novel	E423*	0.46
UCEC	chr3	53240333	Missense_Mutation	novel	D119N	0.31
UCEC	chr3	53225847	Missense_Mutation	novel	R594I	0.49
UCEC	chr3	53230501	Missense_Mutation	novel	H355Y	0.32
UCEC	chr3	53231404	Missense_Mutation	novel	A299T	0.18
UCEC	chr3	53230458	Missense_Mutation	novel	M369T	0.44
UCEC	chr3	53230520	Silent	rs200352787	S348S	0.15
UCEC	chr3	53230574	Silent	NA	H330H	0.08
UCEC	chr3	53225698	Intron	novel		0.47
UCEC	chr3	53234993	Missense_Mutation	novel	E207K	0.56
UCEC	chr3	53225729	Intron	novel		0.18
UCEC	chr3	53242209	Silent	novel	I47I	0.41
UCEC	chr3	53229357	Missense_Mutation	novel	A396V	0.4
UCEC	chr3	53229089	Missense_Mutation	rs140199324	R438Q	0.27
UCEC	chr3	53226804	Missense_Mutation	rs782746915	R550C	0.25
UCEC	chr3	53229414	Missense_Mutation	NA	A377V	0.27
UCEC	chr3	53226861	Missense_Mutation	rs782251102	V531M	0.56
UCEC	chr3	53229290	Silent	rs570396609	G418G	0.26
UCEC	chr3	53230484	Silent	novel	I360I	0.35
UCEC	chr3	53229114	Missense_Mutation	NA	A430T	0.38
UCEC	chr3	53235055	Missense_Mutation	rs781942938	R186H	0.46
UCEC	chr3	53228347	Frame_Shift_Ins	novel	*I470Gfs34**	0.38
UCEC	chr3	53240271	Silent	novel	G139G	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.7778	0.016387
GBM	DEL	0.0832	0.056565
LGG	DEL	0.0799	0.00089193
LUAD	DEL	0.3275	0.0021265
PAAD	DEL	0.1848	0.030662
SARC	DEL	0.2179	0.0034746
SKCM	DEL	0.1608	0.13887
TGCT	AMP	0.1467	0.23596
THYM	DEL	0.0894	0.037527
UCS	DEL	0.5179	4.5515e-05

Survival Analysis

Cancer	P-value	Q-value
THYM	0.041	Kaplan-Meier Survival Analysis
KIRC	0.0013	Kaplan-Meier Survival Analysis
SARC	0.00034	Kaplan-Meier Survival Analysis
MESO	0.0021	Kaplan-Meier Survival Analysis
ACC	0.005	Kaplan-Meier Survival Analysis
UCS	0.033	Kaplan-Meier Survival Analysis
HNSC	0.023	Kaplan-Meier Survival Analysis
SKCM	0.03	Kaplan-Meier Survival Analysis
KIRP	0.011	Kaplan-Meier Survival Analysis
PAAD	0.0041	Kaplan-Meier Survival Analysis
CESC	0.045	Kaplan-Meier Survival Analysis
READ	0.019	Kaplan-Meier Survival Analysis
KICH	0.021	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0082	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163931 (Gene tree)
Gene ID: 7086
Gene Symbol: TKT
Alias: N
Full Name: transketolase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 31,408 bases
Position: chr3:53,224,707-53,256,114
Accession: 11834
RBP type: non-canonical RBP
Summary: This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000296289	TKT-201	1931	XM_011534055	ENSP00000296289	457 (aa)	XP_011532357	A0A0B4J1R6
ENST00000494523	TKT-214	1955	-	-	- (aa)	-	-
ENST00000423516	TKT-202	2075	XM_011534054	ENSP00000391481	631 (aa)	XP_011532356	P29401
ENST00000462138	TKT-208	3010	-	ENSP00000417773	623 (aa)	-	P29401
ENST00000460343	TKT-206	7286	-	-	- (aa)	-	-
ENST00000423525	TKT-203	2831	-	ENSP00000405455	623 (aa)	-	P29401
ENST00000450814	TKT-204	1941	-	ENSP00000413503	153 (aa)	-	F8W888
ENST00000469678	TKT-210	1871	-	ENSP00000418340	334 (aa)	-	E9PFF2
ENST00000460243	TKT-205	615	-	-	- (aa)	-	-
ENST00000472528	TKT-211	1055	-	ENSP00000417312	81 (aa)	-	F8WAX4
ENST00000461139	TKT-207	1972	-	-	- (aa)	-	-
ENST00000487660	TKT-213	610	-	-	- (aa)	-	-
ENST00000483706	TKT-212	565	-	-	- (aa)	-	-
ENST00000466765	TKT-209	693	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000163931's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00030	Pentose phosphate pathway	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163931	Waist Circumference	4.3090000E-005	-
ENSG00000163931	Waist Circumference	8.8600000E-005	-
ENSG00000163931	Metabolism	9E-23	24816252
ENSG00000163931	Electrocardiography	3E-6	27577874
ENSG00000163931	Electrocardiography	7E-10	27659466
ENSG00000163931	Electrocardiography	7E-10	27659466
ENSG00000163931	Metabolism	1E-13	24816252
ENSG00000163931	Electrocardiography	6E-9	27577874

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163931	rs4687718	3	53248287	?	QRS duration	27659466	[0.39-0.75] unit decrease	0.57	EFO_0005054\|EFO_0005055
ENSG00000163931	rs4687718	3	53248287	?	QRS duration	27659466			EFO_0005054\|EFO_0005055
ENSG00000163931	rs4687718	3	53248287	A	QRS duration	27577874	[NR] millisecond decrease	0.63	EFO_0005055
ENSG00000163931	rs4687718	3	53248287	A	QRS duration	27577874	[0.22-0.54] millisecond decrease	0.38	EFO_0005055
ENSG00000163931	rs4687717	3	53248172	T	Blood metabolite levels	24816252	[0.0091-0.0169] unit increase	0.013	EFO_0005664
ENSG00000163931	rs4687717	3	53248172	T	Blood metabolite ratios	24816252	[0.014-0.022] unit decrease	0.018	EFO_0005664
ENSG00000163931	rs4687718	3	53248287	A	QRS duration	30012220	[0.38-0.57] ms decrease	0.474344	EFO_0005055
ENSG00000163931	rs3816767	3	53225980	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000163931	rs4687718	3	53248287	A	QRS duration	30012220	[0.25-0.52] ms decrease	0.38900328	EFO_0005055

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163931's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163931	TKT	99	94.855	ENSMUSG00000021957	Tkt	99	96.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004802	transketolase activity	8419340.9357955.9611778.20667822.	IDA	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005777	peroxisome	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005999	xylulose biosynthetic process	-	TAS	Process
GO:0006098	pentose-phosphate shunt	-	TAS	Process
GO:0009052	pentose-phosphate shunt, non-oxidative branch	9357955.	NAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0031982	vesicle	19190083.	HDA	Component
GO:0040008	regulation of growth	-	IEA	Process
GO:0042803	protein homodimerization activity	9357955.20667822.	IDA	Function
GO:0046166	glyceraldehyde-3-phosphate biosynthetic process	9611778.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048037	cofactor binding	9611778.20667822.	IDA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.