EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29093625Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance.World J Gastroenterol2017 Oct 21Sun CBdoi: 10.3748/wjg.v23.i39.7168.
19461527Expression of annexin a5 is associated with higher tumor stage and poor prognosis in colorectal adenocarcinomas.J Clin Gastroenterol2009 OctXue Gdoi: 10.1097/MCG.0b013e31819cc731.
25899647Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer.Pancreas2015 AugGuillen KPdoi: 10.1097/MPA.0000000000000343.
25080795[The annexin 5 in serums of pregnant women and patients with particular types of cancer].Klin Lab Diagn2014 AprPogosian GG-
18384219Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma.Arch Pathol Lab Med2008 AprChan CMdoi: 10.1043/1543-2165(2008)132[675:PCONCC]2.0.CO;2.
28497265Proteomics analysis of pleomorphic adenoma of the human parotid gland.Eur Arch Otorhinolaryngol2017 AugMutlu Adoi: 10.1007/s00405-017-4608-6
30197345Comparative expression of caspases and annexin V in benign and malignant ovarian tumors.J Cancer Res Ther2018 Jul-SepHassan HAdoi: 10.4103/0973-1482.187282.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr4121686355SilentnovelV9V0.14
BLCAchr4121686324Missense_Mutationrs374862609D20N0.11
BLCAchr4121669716Silentrs750613571G263G0.33
BLCAchr4121668497Missense_MutationnovelL312V0.42
BLCAchr41216682953'UTRnovel0.6
BLCAchr4121677950Missense_MutationnovelA159S0.25
BLCAchr4121670006Missense_MutationNAS243C0.14
BRCAchr4121672593Frame_Shift_InsNAT189Dfs*30.13
BRCAchr41216683303'UTRnovel0.36
BRCAchr4121686367SilentnovelL5L0.43
BRCAchr41216683263'UTRnovel0.19
BRCAchr4121669701SilentNAT268T0.14
CESCchr41216683833'UTRnovel0.46
CESCchr4121684733Nonsense_Mutationrs759419433R45*0.3
COADchr4121683389Missense_MutationnovelA93V0.05
COADchr4121678438Missense_Mutationrs780076315R151W0.43
COADchr4121684717Missense_MutationnovelR50H0.41
COADchr41216683293'UTRnovel0.49
COADchr4121681738SilentnovelV109V0.06
COADchr41216683303'UTRnovel0.2
COADchr4121670000Missense_Mutationrs145513784R245Q0.38
ESCAchr4121672585Missense_MutationnovelE191D0.12
ESCAchr4121678485Nonsense_MutationnovelS135*0.26
GBMchr4121684732Missense_MutationnovelR45Q0.21
HNSCchr4121684745SilentnovelL41L0.05
KIRCchr4121683406SilentNAP87P0.43
LGGchr4121681751Missense_MutationnovelT105K0.38
LIHCchr4121681726SilentnovelI113I0.28
LUADchr4121683420Missense_MutationnovelA83S0.07
LUADchr4121677950Missense_MutationnovelA159S0.24
LUADchr4121686309SilentNAR25R0.29
LUADchr4121686350Missense_MutationnovelD11V0.21
LUADchr4121668527Missense_MutationNAG302R0.11
LUADchr4121686303Missense_MutationnovelA27S0.37
LUADchr4121684703Missense_MutationNAA55S0.24
LUSCchr41216683493'UTRnovel0.23
LUSCchr4121672576SilentnovelF194F0.38
LUSCchr4121669983Missense_MutationNAL251F0.3
LUSCchr4121669984SilentNAY250Y0.29
LUSCchr4121696642Intronnovel0.91
LUSCchr4121672626Missense_MutationnovelA178T0.51
LUSCchr4121668523Missense_MutationNAD303V0.81
OVchr4121668518Missense_MutationNAS305T0.3
OVchr4121677899Missense_MutationnovelA176T0.03
OVchr4121671637Missense_MutationNAD211H0.12
PAADchr4121678385Intronnovel0.13
PCPGchr4121669692Missense_MutationnovelR271S0.33
PRADchr4121678469Silentrs202083195D140D0.15
READchr4121686309Missense_Mutationrs370872365R25W0.58
SARCchr4121672614Missense_MutationnovelA182T0.07
SKCMchr4121669681Missense_MutationnovelS275F0.6
SKCMchr4121686309Missense_Mutationrs370872365R25W0.43
SKCMchr4121672573SilentNAI195I0.2
SKCMchr4121668476Missense_MutationNAD319Y0.37
SKCMchr4121683375Missense_MutationnovelH98D0.28
STADchr4121671596Silentrs532847147T224T0.33
STADchr4121683381Missense_MutationnovelL96M0.44
STADchr4121681748Missense_MutationNAN106S0.26
STADchr4121677892Splice_SiteNAX177_splice0.35
STADchr4121686293Missense_MutationNAG30D0.44
STADchr41216684333'UTRnovel0.19
UCECchr4121678414Splice_SitenovelX158_splice0.68
UCECchr41216683743'UTRnovel0.23
UCECchr4121671625Missense_MutationnovelT215A0.44
UCECchr4121669724Nonsense_MutationNAG261*0.26
UCECchr4121684766Missense_MutationnovelD34Y0.07
UCECchr4121684732Missense_MutationnovelR45Q0.26
UCECchr4121669635Missense_MutationnovelK290N0.27
UCECchr4121683444Missense_MutationnovelG75R0.25
UCECchr41216683973'UTRnovel0.48
UCECchr4121684732Missense_MutationnovelR45Q0.21
UCECchr4121669651Missense_MutationnovelR285M0.05
UCECchr4121696635Intronnovel0.17
UCECchr4121683440Missense_MutationNAK76I0.35
UCECchr4121686362Missense_MutationnovelG7V0.12
UCECchr4121683364Missense_MutationnovelK101N0.36
UCECchr4121672608Nonsense_MutationnovelE184*0.33
UCECchr4121686297Missense_MutationnovelK29E0.32
UCECchr41216683293'UTRnovel0.52
UCECchr4121686318Nonsense_MutationnovelE22*0.52
UCECchr4121681712Missense_MutationNAT118I0.07
UCECchr41216683603'UTRnovel0.39
UCECchr4121683440Missense_MutationnovelK76T0.25
UCECchr4121669693Missense_MutationnovelR271I0.18
UCECchr41216684673'UTRrs7531019070.2
UCECchr4121696628Splice_Regionnovel0.33
UCECchr4121683456Missense_MutationNAS71P0.32
UCECchr4121671615Missense_Mutationrs759791586G218E0.29
UCECchr4121684732Missense_MutationnovelR45Q0.4
UCECchr4121678448Silentrs746976066G147G0.23
UCSchr4121669668Missense_MutationnovelI279M0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.12222.13e-13
LUADDEL0.20740.050802
MESODEL0.36780.075661
PRADDEL0.0650.0026708

Survival Analysis
CancerP-value Q-value
KIRC0.037

Kaplan-Meier Survival Analysis

STAD0.0001

Kaplan-Meier Survival Analysis

MESO0.004

Kaplan-Meier Survival Analysis

HNSC0.00087

Kaplan-Meier Survival Analysis

LUSC0.0098

Kaplan-Meier Survival Analysis

ESCA0.00089

Kaplan-Meier Survival Analysis

PAAD0.048

Kaplan-Meier Survival Analysis

BLCA0.00027

Kaplan-Meier Survival Analysis

CESC0.0018

Kaplan-Meier Survival Analysis

LAML0.0085

Kaplan-Meier Survival Analysis

UCEC0.00089

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

THCA0.018

Kaplan-Meier Survival Analysis

LUAD0.039

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000164111 (Gene tree)
Gene ID
308
Gene Symbol
ANXA5
Alias
ENX2|ANX5
Full Name
annexin A5
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
29,159 bases
Position
chr4:121,667,955-121,697,113
Accession
543
RBP type
non-canonical RBP
Summary
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15090652Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa.Proc Natl Acad Sci U S A2004 Apr 27Rebello G-
8778191Species specificity for HBsAg binding protein endonexin II.J Hepatol1996 Marde Bruin WC-
15827323Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer.Mol Cancer Ther2005 AprLiao X-
19762561Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.Am J Respir Crit Care Med2009 Dec 1Lee HSdoi: 10.1164/rccm.200905-0740OC
20798520Effect of anandamide in Plasmodium Berghei-infected mice.Cell Physiol Biochem2010Bobbala Ddoi: 10.1159/000320559
25540384Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection.J Virol2015 MarBaquero-Perez Bdoi: 10.1128/JVI.03421-14
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000511552ANXA5-2061036--- (aa)--
ENST00000501272ANXA5-2021363-ENSP00000424106260 (aa)-D6RBL5
ENST00000513523ANXA5-208582--- (aa)--
ENST00000506395ANXA5-2031606-ENSP00000421421163 (aa)-E9PHT9
ENST00000509648ANXA5-2051083--- (aa)--
ENST00000515017ANXA5-2101190-ENSP00000424199220 (aa)-D6RBE9
ENST00000513728ANXA5-209447-ENSP0000042713535 (aa)-D6RCN3
ENST00000515717ANXA5-211594--- (aa)--
ENST00000509016ANXA5-204556--- (aa)--
ENST00000296511ANXA5-2011762-ENSP00000296511320 (aa)-P08758
ENST00000513428ANXA5-207868--- (aa)--
Gene Model
Click here to download ENSG00000164111's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000164111Arteries7.0030000E-005-
ENSG00000164111Smoking5E-721685187
ENSG00000164111Pulmonary Disease, Chronic Obstructive5E-721685187
ENSG00000164111Diabetes Mellitus, Type 29E-617554300
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000164111rs556455434121686023CAge at smoking initiation in chronic obstructive pulmonary disease21685187unit increase0.228EFO_0000341|EFO_0005670
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164111's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002576platelet degranulation-TASProcess
GO:0004859phospholipase inhibitor activity2967495.TASFunction
GO:0005388calcium-transporting ATPase activity21873635.IBAFunction
GO:0005509calcium ion binding-IEAFunction
GO:0005515protein binding21873635.IBAFunction
GO:0005515protein binding21044950.IPIFunction
GO:0005543phospholipid binding2967291.TASFunction
GO:0005544calcium-dependent phospholipid binding21873635.IBAFunction
GO:0005544calcium-dependent phospholipid binding2138016.IDAFunction
GO:0005576extracellular region-TASComponent
GO:0005737cytoplasm16130169.TASComponent
GO:0005829cytosol-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0007165signal transduction16130169.TASProcess
GO:0007596blood coagulation-IEAProcess
GO:0008201heparin binding21873635.IBAFunction
GO:0009897external side of plasma membrane-IEAComponent
GO:0010033response to organic substance21873635.IBAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016020membrane21873635.IBAComponent
GO:0017046peptide hormone binding21873635.IBAFunction
GO:0030195negative regulation of blood coagulation21873635.IBAProcess
GO:0030971receptor tyrosine kinase binding21873635.IBAFunction
GO:0043065positive regulation of apoptotic process21873635.IBAProcess
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0043086negative regulation of catalytic activity-IEAProcess
GO:0051260protein homooligomerization21873635.IBAProcess
GO:0051283negative regulation of sequestering of calcium ion21873635.IBAProcess
GO:0051592response to calcium ion21873635.IBAProcess
GO:0060090molecular adaptor activity21873635.IBAFunction
GO:0062023collagen-containing extracellular matrix28675934.HDAComponent
GO:0062023collagen-containing extracellular matrix28327460.HDAComponent
GO:0070062extracellular exosome19056867.20458337.21362503.23533145.HDAComponent
GO:0070588calcium ion transmembrane transport-IEAProcess
GO:0071284cellular response to lead ion21873635.IBAProcess
GO:0072563endothelial microparticle-IEAComponent
GO:0097066response to thyroid hormone21873635.IBAProcess
GO:0097211cellular response to gonadotropin-releasing hormone21873635.IBAProcess
GO:0099132ATP hydrolysis coupled cation transmembrane transport-IEAProcess
GO:1901317regulation of flagellated sperm motility21873635.IBAProcess
GO:1902721negative regulation of prolactin secretion21873635.IBAProcess
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