EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28738408	cGAS surveillance of micronuclei links genome instability to innate immunity.	Nature	2017 Aug 24	Mackenzie KJ	doi: 10.1038/nature23449
30356214	Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.	Nature	2018 Nov	Liu H	doi: 10.1038/s41586-018-0629-6

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	73451624	Silent	novel	V186V	0.06
BLCA	chr6	73440289	Nonsense_Mutation	NA	S345*	0.25
BLCA	chr6	73452220	5'UTR	novel		0.36
BLCA	chr6	73440307	Missense_Mutation	rs190867294	R339H	0.16
BLCA	chr6	73452135	Missense_Mutation	novel	G16E	0.38
BLCA	chr6	73440294	Nonsense_Mutation	NA	W343*	0.34
BRCA	chr6	73425497	Missense_Mutation	NA	F433L	0.25
CESC	chr6	73425456	Missense_Mutation	NA	T447I	0.29
CESC	chr6	73451813	Silent	NA	Q123Q	0.56
CESC	chr6	73428799	Missense_Mutation	rs531954415	R376Q	0.4
COAD	chr6	73445704	Missense_Mutation	NA	V234A	0.37
COAD	chr6	73451723	Silent	rs757662937	L153L	0.18
COAD	chr6	73451946	Missense_Mutation	novel	A79V	0.27
COAD	chr6	73451719	Missense_Mutation	novel	R155W	0.23
COAD	chr6	73428799	Missense_Mutation	rs531954415	R376Q	0.17
COAD	chr6	73451969	Silent	NA	R71R	0.51
COAD	chr6	73428720	Missense_Mutation	NA	E402D	0.27
COAD	chr6	73440307	Missense_Mutation	rs190867294	R339H	0.14
COAD	chr6	73445634	Frame_Shift_Ins	novel	*K258Efs12**	0.06
COAD	chr6	73451578	Missense_Mutation	NA	A202T	0.32
HNSC	chr6	73451602	Silent	novel	L194L	0.37
HNSC	chr6	73440289	Missense_Mutation	novel	S345L	0.09
HNSC	chr6	73425496	Missense_Mutation	novel	S434P	0.2
KIRP	chr6	73451951	Silent	novel	T77T	0.21
KIRP	chr6	73425347	Silent	NA	Y483Y	0.44
KIRP	chr6	73440221	Missense_Mutation	novel	N368H	0.27
LGG	chr6	73425472	Missense_Mutation	NA	F442V	0.27
LIHC	chr6	73451534	Missense_Mutation	NA	E216D	0.29
LIHC	chr6	73440287	Missense_Mutation	novel	A346T	0.03
LIHC	chr6	73452166	Missense_Mutation	NA	G6R	0.26
LUAD	chr6	73440371	Missense_Mutation	NA	V318L	0.51
LUSC	chr6	73425487	Missense_Mutation	novel	H437D	0.25
LUSC	chr6	73445684	Missense_Mutation	novel	E241K	0.32
LUSC	chr6	73452183	5'UTR	novel		0.24
OV	chr6	73425371	Silent	NA	L475L	0.16
READ	chr6	73425300	Missense_Mutation	NA	R499I	0.26
READ	chr6	73451749	Missense_Mutation	rs373045600	G145S	0.43
READ	chr6	73428730	Frame_Shift_Ins	NA	*N399Ifs22**	0.09
READ	chr6	73425292	Nonsense_Mutation	NA	E502*	0.38
READ	chr6	73428725	Nonsense_Mutation	NA	E401*	0.33
SKCM	chr6	73440423	Silent	novel	R300R	0.42
SKCM	chr6	73440346	Missense_Mutation	NA	S326L	0.65
SKCM	chr6	73425574	Missense_Mutation	NA	D408N	0.5
SKCM	chr6	73425339	Missense_Mutation	NA	P486L	0.43
SKCM	chr6	73445636	Missense_Mutation	NA	P257S	0.55
SKCM	chr6	73440387	Silent	novel	I312I	0.4
SKCM	chr6	73445556	Silent	NA	I283I	0.39
SKCM	chr6	73445678	Missense_Mutation	NA	S243T	0.32
SKCM	chr6	73445636	Missense_Mutation	NA	P257S	0.45
STAD	chr6	73425493	Missense_Mutation	novel	S435P	0.31
STAD	chr6	73451749	Missense_Mutation	NA	G145R	0.2
STAD	chr6	73428779	Missense_Mutation	rs370272118	E383K	0.25
STAD	chr6	73452149	Silent	NA	R11R	0.15
STAD	chr6	73440307	Missense_Mutation	rs190867294	R339H	0.2
STAD	chr6	73428799	Missense_Mutation	novel	R376L	0.13
STAD	chr6	73428779	Missense_Mutation	rs370272118	E383K	0.21
STAD	chr6	73428796	Missense_Mutation	NA	L377P	0.25
THCA	chr6	73451666	Silent	NA	L172L	0.18
UCEC	chr6	73445630	Nonsense_Mutation	NA	E259*	0.34
UCEC	chr6	73428771	Missense_Mutation	NA	E385D	0.35
UCEC	chr6	73440299	Missense_Mutation	NA	N342H	0.34
UCEC	chr6	73445661	Nonsense_Mutation	NA	Y248*	0.22
UCEC	chr6	73445634	Silent	rs777110749	P257P	0.29
UCEC	chr6	73425251	Silent	rs200618059	E515E	0.31
UCEC	chr6	73445723	Missense_Mutation	novel	V228I	0.34
UCEC	chr6	73425145	3'UTR	rs764904396		0.17
UCEC	chr6	73425360	Missense_Mutation	novel	K479T	0.39
UCEC	chr6	73425194	3'UTR	novel		0.4
UCEC	chr6	73440307	Missense_Mutation	rs190867294	R339H	0.17
UCEC	chr6	73440307	Missense_Mutation	rs190867294	R339H	0.21
UCEC	chr6	73445641	Missense_Mutation	novel	R255I	0.28
UCEC	chr6	73425209	3'UTR	novel		0.37
UCEC	chr6	73425532	Nonsense_Mutation	novel	E422*	0.27
UCEC	chr6	73428779	Missense_Mutation	rs370272118	E383K	0.21
UCEC	chr6	73428800	Silent	novel	R376R	0.08
UCEC	chr6	73425144	3'UTR	novel		0.39
UCEC	chr6	73440340	Frame_Shift_Ins	novel	*S328Kfs2**	0.27
UCEC	chr6	73445641	Missense_Mutation	novel	R255I	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2941	3.4915e-05
CHOL	DEL	0.5556	0.022382
ESCA	DEL	0.2011	0.036953
LUAD	DEL	0.3411	0.0021365
MESO	DEL	0.2759	0.05642
PAAD	DEL	0.2935	0.11274
SARC	DEL	0.2412	0.0021591
SKCM	DEL	0.376	1.5442e-06
STAD	DEL	0.1224	0.0044196

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0097	Kaplan-Meier Survival Analysis
STAD	0.00016	Kaplan-Meier Survival Analysis
MESO	0.001	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
COAD	0.018	Kaplan-Meier Survival Analysis
PAAD	0.038	Kaplan-Meier Survival Analysis
LAML	0.037	Kaplan-Meier Survival Analysis
GBM	0.036	Kaplan-Meier Survival Analysis
LIHC	0.026	Kaplan-Meier Survival Analysis
LUAD	0.026	Kaplan-Meier Survival Analysis
UVM	0.00027	Kaplan-Meier Survival Analysis

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000164430 (Gene tree)
Gene ID: 115004
Gene Symbol: CGAS
Alias: cGAS|C6orf150|MB21D1
Full Name: cyclic GMP-AMP synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 38,816 bases
Position: chr6:73,413,515-73,452,330
Accession: 21367
RBP type: non-canonical RBP
Summary: (Cyclic GMP-AMP Synthase) is a Protein Coding gene. Diseases associated with CGAS include Herpes Simplex and Aicardi-Goutieres Syndrome. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Human cytomegalovirus infection. An important paralog of this gene is MAB21L1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25752600	OASes and STING: adaptive evolution in concert.	Genome Biol Evol	2015 Mar 9	Mozzi A	doi: 10.1093/gbe/evv046.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370318	CGAS-202	1917	-	ENSP00000359342	447 (aa)	-	Q8N884
ENST00000459924	CGAS-203	861	-	-	- (aa)	-	-
ENST00000370315	CGAS-201	3182	-	ENSP00000359339	522 (aa)	-	Q8N884

Gene Model

Click here to download ENSG00000164430's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04623	Cytosolic DNA-sensing pathway	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164430	Blood Pressure	7.8560000E-005	-
ENSG00000164430	Creatinine	7.2950000E-006	-
ENSG00000164430	Creatinine	5.0790000E-006	-
ENSG00000164430	3-hydroxy-1-methylpropylmercapturic acid	4E-7	26053186
ENSG00000164430	Smoking	4E-7	26053186
ENSG00000164430	S-(3-hydroxypropyl)cysteine N-acetate	5E-6	26053186
ENSG00000164430	Smoking	5E-6	26053186

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164430	rs311671	6	73429655	?	3-hydroxypropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.493	EFO_0004318\|EFO_0007014
ENSG00000164430	rs311671	6	73429655	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.4928	EFO_0004318\|EFO_0007015

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164430's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002218	activation of innate immune response	23929945.24077100.26046437.28363908.30007416.	IDA	Process
GO:0002218	activation of innate immune response	23258413.	IMP	Process
GO:0002230	positive regulation of defense response to virus by host	23929945.24077100.26046437.	IDA	Process
GO:0002230	positive regulation of defense response to virus by host	23258413.	IMP	Process
GO:0002637	regulation of immunoglobulin production	-	IEA	Process
GO:0003677	DNA binding	23258413.	IDA	Function
GO:0003682	chromatin binding	28738408.	IDA	Function
GO:0003690	double-stranded DNA binding	24077100.28363908.29937271.30007416.	IDA	Function
GO:0005515	protein binding	26046437.30135424.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005634	nucleus	29937271.30356214.	IDA	Component
GO:0005829	cytosol	23258413.29937271.30356214.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	28738408.	IDA	Process
GO:0008340	determination of adult lifespan	-	IEA	Process
GO:0010753	positive regulation of cGMP-mediated signaling	23258413.24077100.28738408.	IDA	Process
GO:0016032	viral process	-	IEA	Process
GO:0032481	positive regulation of type I interferon production	24077100.26046437.28363908.28738408.	IDA	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0035861	site of double-strand break	30356214.	IDA	Component
GO:0038001	paracrine signaling	24077100.	IDA	Process
GO:0043950	positive regulation of cAMP-mediated signaling	23258413.24077100.28738408.30007416.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0050863	regulation of T cell activation	-	IEA	Process
GO:0051607	defense response to virus	21478870.23929945.24077100.26046437.	IDA	Process
GO:0061501	cyclic-GMP-AMP synthase activity	23258412.	EXP	Function
GO:0061501	cyclic-GMP-AMP synthase activity	23258413.24077100.26300263.28214358.28363908.28738408.28934246.29937271.30007416.	IDA	Function
GO:0071360	cellular response to exogenous dsRNA	23258413.24077100.28214358.28363908.	IDA	Process
GO:2000042	negative regulation of double-strand break repair via homologous recombination	30356214.	IDA	Process
GO:2000774	positive regulation of cellular senescence	-	ISS	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.