EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22761399	Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells.	Mol Cell Proteomics	2012 Oct	Sudhir PR	-
23722546	Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis.	Cancer Res	2013 Aug 1	Levi L	doi: 10.1158/0008-5472.CAN-13-0384
25797252	CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.	Oncotarget	2015 Mar 20	Xia SL	-
27418530	High FABP5 Versus CRABPII Expression Ratio in Recurrent Craniopharyngiomas: Implications for Future Treatment.	World Neurosurg	2016 Oct	Li Q	doi: 10.1016/j.wneu.2016.05.063
28374947	Fatty acid-binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition.	Cancer Med	2017 May	Ohata T	doi: 10.1002/cam4.1020
28701570	Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients.	Oncologist	2017 Nov	Guaita-Esteruelas S	doi: 10.1634/theoncologist.2016-0483
29957468	Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma.	Biomed Pharmacother	2018 Oct	Pan L	doi: 10.1016/j.biopha.2018.06.040
21356353	Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy.	Am J Pathol	2011 Mar	Liu RZ	doi: 10.1016/j.ajpath.2010.11.075.
27644245	FABP5 correlates with poor prognosis and promotes tumor cell growth and metastasis in cervical cancer.	Tumour Biol	2016 Nov	Wang W	-
18360704	Expression of cutaneous fatty acid-binding protein (C-FABP) in prostate cancer: potential prognostic marker and target for tumourigenicity-suppression.	Int J Oncol	2008 Apr	Morgan EA	-
26614767	The cancer-promoting gene fatty acid-binding protein 5 (FABP5) is epigenetically regulated during human prostate carcinogenesis.	Biochem J	2016 Feb 15	Kawaguchi K	doi: 10.1042/BJ20150926
24189640	The expression of C-FABP and PPARγ and their prognostic significance in prostate cancer.	Int J Oncol	2014 Jan	Forootan FS	doi: 10.3892/ijo.2013.2166
20040021	Fatty-acid-binding protein 5 promotes cell proliferation and invasion in oral squamous cell carcinoma.	J Oral Pathol Med	2010 Apr	Fang LY	doi: 10.1111/j.1600-0714.2009.00836.x
17428383	[Expression of fatty acid binding protein in human breast cancer tissues].	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi	2007 Apr	Li H	-
18729184	Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach.	Int J Cancer	2008 Nov 15	Li Z	doi: 10.1002/ijc.23808.
29906613	Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-??B) signaling in cancer cells.	Biochim Biophys Acta Mol Cell Biol Lipids	2018 Sep	Senga S	doi: 10.1016/j.bbalip.2018.06.010
30917456	[FABP5 promotes cell growth, invasion and metastasis in cervical cancer].	Zhonghua Zhong Liu Za Zhi	2019 Mar 23	Zhan YZ	doi: 10.3760/cma.j.issn.0253-3766.2019.03.009.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	81283410	Missense_Mutation	novel	D42N	0.21
BRCA	chr8	81284623	3'UTR	novel		0.23
BRCA	chr8	81284653	3'UTR	novel		0.1
CESC	chr8	81280610	Silent	novel	Q5Q	0.21
COAD	chr8	81280599	Missense_Mutation	novel	A2T	0.29
COAD	chr8	81284640	3'UTR	novel		0.2
COAD	chr8	81283451	Missense_Mutation	novel	K55N	0.36
ESCA	chr8	81280565	5'UTR	novel		0.34
HNSC	chr8	81283416	Missense_Mutation	rs145774881	I44V	0.09
LUSC	chr8	81283438	Missense_Mutation	novel	N51I	0.1
LUSC	chr8	81283934	Missense_Mutation	rs757111208	S105I	0.17
LUSC	chr8	81283415	Silent	rs143988575	C43C	0.52
LUSC	chr8	81283454	Silent	novel	T56T	0.24
LUSC	chr8	81284561	Silent	NA	V134V	0.15
READ	chr8	81283932	Missense_Mutation	NA	E104D	0.34
SKCM	chr8	81283490	Silent	novel	T68T	0.62
SKCM	chr8	81283491	Silent	novel	L69L	0.64
SKCM	chr8	81283924	Missense_Mutation	NA	G102R	0.2
STAD	chr8	81284547	Missense_Mutation	NA	I130V	0.08
STAD	chr8	81283394	Silent	rs765699819	G36G	0.13
UCEC	chr8	81283966	Missense_Mutation	NA	L116I	0.59
UCEC	chr8	81283883	Missense_Mutation	rs763394711	N88S	0.36
UCEC	chr8	81280599	Missense_Mutation	novel	A2T	0.28
UCEC	chr8	81284545	Missense_Mutation	rs201701039	R129Q	0.37
UCEC	chr8	81280585	5'UTR	novel		0.49
UCEC	chr8	81284642	3'UTR	novel		0.26
UCEC	chr8	81284567	Nonstop_Mutation	NA	136Yext56	0.5
UCEC	chr8	81280583	5'UTR	novel		0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.1004	0.15559
PRAD	AMP	0.2581	3.7005e-05
READ	DEL	0.0242	0.20625
SARC	AMP	0.2802	0.18425
TGCT	AMP	0.68	0.13696
THCA	DEL	0.008	0.038162

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0077	Kaplan-Meier Survival Analysis
SKCM	0.0035	Kaplan-Meier Survival Analysis
LAML	0.04	Kaplan-Meier Survival Analysis
GBM	0.0043	Kaplan-Meier Survival Analysis
LIHC	0.0026	Kaplan-Meier Survival Analysis
LUAD	0.005	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000164687 (Gene tree)
Gene ID: 2171
Gene Symbol: FABP5
Alias: E-FABP|PA-FABP|KFABP
Full Name: fatty acid binding protein 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,415 bases
Position: chr8:81,280,363-81,284,777
Accession: 3560
RBP type: non-canonical RBP
Summary: This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21244687	Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies.	BMC Res Notes	2011 Jan 18	Park JS	doi: 10.1186/1756-0500-4-8.
30195591	A novel role of endothelial autophagy as a regulator of myocardial fatty acid oxidation.	J Thorac Cardiovasc Surg	2019 Jan	Altamimi TR	doi: 10.1016/j.jtcvs.2018.07.047
18286188	Brain fatty acid binding protein (Fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain.	PLoS One	2008 Feb 20	Gerstner JR	doi: 10.1371/journal.pone.0001631.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000297258	FABP5-201	851	-	ENSP00000297258	135 (aa)	-	Q01469
ENST00000396359	FABP5-202	986	-	ENSP00000379647	101 (aa)	-	I6L8B7
ENST00000481695	FABP5-203	756	-	-	- (aa)	-	-
ENST00000486269	FABP5-204	579	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000164687's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03320	PPAR signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164687	Child Development Disorders, Pervasive	2.7469000E-005	-
ENSG00000164687	Child Development Disorders, Pervasive	2.2056000E-005	-
ENSG00000164687	Child Development Disorders, Pervasive	4.4412000E-007	-
ENSG00000164687	Child Development Disorders, Pervasive	3.1377000E-005	-
ENSG00000164687	Receptors, Tumor Necrosis Factor	6.3650000E-005	-
ENSG00000164687	Sleep	7E-6	27126917

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164687's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000164687	FABP5	100	83.168	ENSMUSG00000027533	Fabp5	100	80.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001972	retinoic acid binding	-	IEA	Function
GO:0005504	fatty acid binding	8092987.	IDA	Function
GO:0005515	protein binding	12839573.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	24692551.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	8092987.	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006006	glucose metabolic process	-	IEA	Process
GO:0006629	lipid metabolic process	8092987.	TAS	Process
GO:0006656	phosphatidylcholine biosynthetic process	-	IEA	Process
GO:0008289	lipid binding	1512466.	TAS	Function
GO:0008544	epidermis development	1512466.	TAS	Process
GO:0010829	negative regulation of glucose transmembrane transport	-	IEA	Process
GO:0014069	postsynaptic density	-	ISS	Component
GO:0019433	triglyceride catabolic process	-	TAS	Process
GO:0030054	cell junction	-	IEA	Component
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0031392	regulation of prostaglandin biosynthetic process	-	IEA	Process
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	-	IEA	Process
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0042593	glucose homeostasis	-	IEA	Process
GO:0042802	identical protein binding	24531463.	IDA	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045202	synapse	-	ISS	Component
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0051930	regulation of sensory perception of pain	-	IEA	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	-	ISS	Process
GO:0120162	positive regulation of cold-induced thermogenesis	24603714.	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.