EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22761399Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells.Mol Cell Proteomics2012 OctSudhir PR-
23722546Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis.Cancer Res2013 Aug 1Levi Ldoi: 10.1158/0008-5472.CAN-13-0384
25797252CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.Oncotarget2015 Mar 20Xia SL-
27418530High FABP5 Versus CRABPII Expression Ratio in Recurrent Craniopharyngiomas: Implications for Future Treatment.World Neurosurg2016 OctLi Qdoi: 10.1016/j.wneu.2016.05.063
28374947Fatty acid-binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition.Cancer Med2017 MayOhata Tdoi: 10.1002/cam4.1020
28701570Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients.Oncologist2017 NovGuaita-Esteruelas Sdoi: 10.1634/theoncologist.2016-0483
29957468Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma.Biomed Pharmacother2018 OctPan Ldoi: 10.1016/j.biopha.2018.06.040
21356353Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy.Am J Pathol2011 MarLiu RZdoi: 10.1016/j.ajpath.2010.11.075.
27644245FABP5 correlates with poor prognosis and promotes tumor cell growth and metastasis in cervical cancer.Tumour Biol2016 NovWang W-
18360704Expression of cutaneous fatty acid-binding protein (C-FABP) in prostate cancer: potential prognostic marker and target for tumourigenicity-suppression.Int J Oncol2008 AprMorgan EA-
26614767The cancer-promoting gene fatty acid-binding protein 5 (FABP5) is epigenetically regulated during human prostate carcinogenesis.Biochem J2016 Feb 15Kawaguchi Kdoi: 10.1042/BJ20150926
24189640The expression of C-FABP and PPARγ and their prognostic significance in prostate cancer.Int J Oncol2014 JanForootan FSdoi: 10.3892/ijo.2013.2166
20040021Fatty-acid-binding protein 5 promotes cell proliferation and invasion in oral squamous cell carcinoma.J Oral Pathol Med2010 AprFang LYdoi: 10.1111/j.1600-0714.2009.00836.x
17428383[Expression of fatty acid binding protein in human breast cancer tissues].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2007 AprLi H-
18729184Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach.Int J Cancer2008 Nov 15Li Zdoi: 10.1002/ijc.23808.
29906613Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-??B) signaling in cancer cells.Biochim Biophys Acta Mol Cell Biol Lipids2018 SepSenga Sdoi: 10.1016/j.bbalip.2018.06.010
30917456[FABP5 promotes cell growth, invasion and metastasis in cervical cancer].Zhonghua Zhong Liu Za Zhi2019 Mar 23Zhan YZdoi: 10.3760/cma.j.issn.0253-3766.2019.03.009.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr881283410Missense_MutationnovelD42N0.21
BRCAchr8812846233'UTRnovel0.23
BRCAchr8812846533'UTRnovel0.1
CESCchr881280610SilentnovelQ5Q0.21
COADchr881280599Missense_MutationnovelA2T0.29
COADchr8812846403'UTRnovel0.2
COADchr881283451Missense_MutationnovelK55N0.36
ESCAchr8812805655'UTRnovel0.34
HNSCchr881283416Missense_Mutationrs145774881I44V0.09
LUSCchr881283438Missense_MutationnovelN51I0.1
LUSCchr881283934Missense_Mutationrs757111208S105I0.17
LUSCchr881283415Silentrs143988575C43C0.52
LUSCchr881283454SilentnovelT56T0.24
LUSCchr881284561SilentNAV134V0.15
READchr881283932Missense_MutationNAE104D0.34
SKCMchr881283490SilentnovelT68T0.62
SKCMchr881283491SilentnovelL69L0.64
SKCMchr881283924Missense_MutationNAG102R0.2
STADchr881284547Missense_MutationNAI130V0.08
STADchr881283394Silentrs765699819G36G0.13
UCECchr881283966Missense_MutationNAL116I0.59
UCECchr881283883Missense_Mutationrs763394711N88S0.36
UCECchr881280599Missense_MutationnovelA2T0.28
UCECchr881284545Missense_Mutationrs201701039R129Q0.37
UCECchr8812805855'UTRnovel0.49
UCECchr8812846423'UTRnovel0.26
UCECchr881284567Nonstop_MutationNA*136Yext*560.5
UCECchr8812805835'UTRnovel0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCAMP0.10040.15559
PRADAMP0.25813.7005e-05
READDEL0.02420.20625
SARCAMP0.28020.18425
TGCTAMP0.680.13696
THCADEL0.0080.038162

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

ACC0.0077

Kaplan-Meier Survival Analysis

SKCM0.0035

Kaplan-Meier Survival Analysis

LAML0.04

Kaplan-Meier Survival Analysis

GBM0.0043

Kaplan-Meier Survival Analysis

LIHC0.0026

Kaplan-Meier Survival Analysis

LUAD0.005

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000164687 (Gene tree)
Gene ID
2171
Gene Symbol
FABP5
Alias
E-FABP|PA-FABP|KFABP
Full Name
fatty acid binding protein 5
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
4,415 bases
Position
chr8:81,280,363-81,284,777
Accession
3560
RBP type
non-canonical RBP
Summary
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21244687Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies.BMC Res Notes2011 Jan 18Park JSdoi: 10.1186/1756-0500-4-8.
30195591A novel role of endothelial autophagy as a regulator of myocardial fatty acid oxidation.J Thorac Cardiovasc Surg2019 JanAltamimi TRdoi: 10.1016/j.jtcvs.2018.07.047
18286188Brain fatty acid binding protein (Fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain.PLoS One2008 Feb 20Gerstner JRdoi: 10.1371/journal.pone.0001631.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000297258FABP5-201851-ENSP00000297258135 (aa)-Q01469
ENST00000396359FABP5-202986-ENSP00000379647101 (aa)-I6L8B7
ENST00000481695FABP5-203756--- (aa)--
ENST00000486269FABP5-204579--- (aa)--
Gene Model
Click here to download ENSG00000164687's gene model file
Pathways
Pathway IDPathway NameSource
hsa03320PPAR signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000164687Child Development Disorders, Pervasive2.7469000E-005-
ENSG00000164687Child Development Disorders, Pervasive2.2056000E-005-
ENSG00000164687Child Development Disorders, Pervasive4.4412000E-007-
ENSG00000164687Child Development Disorders, Pervasive3.1377000E-005-
ENSG00000164687Receptors, Tumor Necrosis Factor6.3650000E-005-
ENSG00000164687Sleep7E-627126917
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164687's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000164687FABP510083.168ENSMUSG00000027533Fabp510080.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001972retinoic acid binding-IEAFunction
GO:0005504fatty acid binding8092987.IDAFunction
GO:0005515protein binding12839573.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus24692551.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm8092987.IDAComponent
GO:0005737cytoplasm16130169.TASComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-TASComponent
GO:0006006glucose metabolic process-IEAProcess
GO:0006629lipid metabolic process8092987.TASProcess
GO:0006656phosphatidylcholine biosynthetic process-IEAProcess
GO:0008289lipid binding1512466.TASFunction
GO:0008544epidermis development1512466.TASProcess
GO:0010829negative regulation of glucose transmembrane transport-IEAProcess
GO:0014069postsynaptic density-ISSComponent
GO:0019433triglyceride catabolic process-TASProcess
GO:0030054cell junction-IEAComponent
GO:0030667secretory granule membrane-TASComponent
GO:0031392regulation of prostaglandin biosynthetic process-IEAProcess
GO:0035360positive regulation of peroxisome proliferator activated receptor signaling pathway-IEAProcess
GO:0035578azurophil granule lumen-TASComponent
GO:0042593glucose homeostasis-IEAProcess
GO:0042802identical protein binding24531463.IDAFunction
GO:0043312neutrophil degranulation-TASProcess
GO:0045202synapse-ISSComponent
GO:0045211postsynaptic membrane-IEAComponent
GO:0051930regulation of sensory perception of pain-IEAProcess
GO:0070062extracellular exosome20458337.23533145.HDAComponent
GO:0099178regulation of retrograde trans-synaptic signaling by endocanabinoid-ISSProcess
GO:0120162positive regulation of cold-induced thermogenesis24603714.ISSProcess
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