EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr7	740848	Silent	rs762800769	G270G	0.79
BLCA	chr7	763893	Missense_Mutation	novel	E568Q	0.1
BLCA	chr7	774067	Missense_Mutation	NA	E651K	0.05
BLCA	chr7	770503	Missense_Mutation	novel	V606L	0.26
BRCA	chr7	785635	Silent	NA	A850A	0.24
BRCA	chr7	780132	Missense_Mutation	novel	D807N	0.25
BRCA	chr7	780024	Missense_Mutation	NA	L771V	0.14
BRCA	chr7	770532	Silent	NA	P615P	0.4
CESC	chr7	774129	Silent	novel	A671A	0.21
CESC	chr7	785699	3'UTR	novel		0.43
CESC	chr7	763961	Silent	rs766844619	I590I	0.09
CESC	chr7	779990	Silent	novel	V759V	0.27
COAD	chr7	774165	Silent	NA	A683A	0.31
COAD	chr7	780130	Missense_Mutation	novel	Q806P	0.31
COAD	chr7	756811	Silent	rs143584365	T429T	0.42
COAD	chr7	769182	Intron	novel		0.38
COAD	chr7	785590	Silent	NA	H835H	0.11
COAD	chr7	729799	Silent	rs751760178	D244D	0.29
COAD	chr7	740906	Silent	NA	L290L	0.09
COAD	chr7	770580	Silent	rs149101412	T631T	0.49
COAD	chr7	780079	Missense_Mutation	NA	Y789C	0.13
COAD	chr7	770583	Silent	NA	V632V	0.39
COAD	chr7	774066	Silent	rs755182384	L650L	0.14
ESCA	chr7	770627	Intron	novel		0.15
ESCA	chr7	785595	Missense_Mutation	rs115620965	S837L	0.15
ESCA	chr7	729780	Missense_Mutation	novel	G238A	0.11
GBM	chr7	774067	Missense_Mutation	NA	E651K	0.57
GBM	chr7	740867	Missense_Mutation	rs749838774	R277C	0.19
GBM	chr7	779964	Missense_Mutation	rs779271163	R751C	0.13
GBM	chr7	780031	Missense_Mutation	novel	C773Y	0.23
GBM	chr7	770741	Intron	novel		0.46
GBM	chr7	729662	Splice_Site	novel	X199_splice	0.47
GBM	chr7	763926	Missense_Mutation	rs769804298	A579T	0.37
GBM	chr7	770503	Missense_Mutation	rs200034358	V606M	0.14
GBM	chr7	756787	Silent	novel	T421T	0.13
HNSC	chr7	785694	3'UTR	novel		0.14
HNSC	chr7	754695	Silent	novel	V377V	0.28
KIRC	chr7	740829	Missense_Mutation	rs779352236	A264V	0.17
KIRP	chr7	785742	3'UTR	novel		0.33
KIRP	chr7	729708	Missense_Mutation	NA	Q214P	0.22
KIRP	chr7	740940	Missense_Mutation	novel	V301D	0.18
KIRP	chr7	770807	Intron	novel		0.36
KIRP	chr7	763819	Missense_Mutation	NA	M543R	0.17
LGG	chr7	774083	Missense_Mutation	NA	D656G	0.26
LIHC	chr7	770533	Missense_Mutation	NA	S616P	0.59
LIHC	chr7	754587	Splice_Site	novel	X342_splice	0.39
LUAD	chr7	754794	Silent	rs779072395	T410T	0.09
LUAD	chr7	774127	Missense_Mutation	rs751454661	A671T	0.16
LUAD	chr7	756962	Missense_Mutation	novel	A480T	0.23
LUAD	chr7	740826	Missense_Mutation	NA	R263L	0.27
LUAD	chr7	763929	Missense_Mutation	NA	H580Y	0.19
LUAD	chr7	729824	Nonsense_Mutation	novel	R253*	0.18
LUAD	chr7	763829	Silent	NA	L546L	0.14
LUAD	chr7	769157	Intron	novel		0.28
LUAD	chr7	763962	Missense_Mutation	rs754002298	V591I	0.13
LUAD	chr7	761770	Silent	NA	R496R	0.29
LUAD	chr7	774081	Missense_Mutation	NA	K655N	0.48
LUAD	chr7	763910	Silent	NA	S573S	0.22
LUSC	chr7	763916	Silent	novel	L575L	0.72
LUSC	chr7	754715	Missense_Mutation	novel	P384L	0.14
LUSC	chr7	756870	Missense_Mutation	novel	S449F	0.37
LUSC	chr7	785671	3'UTR	novel		0.28
LUSC	chr7	774114	Silent	novel	A666A	0.47
LUSC	chr7	756868	Silent	NA	P448P	0.37
LUSC	chr7	770524	Silent	novel	L613L	0.11
LUSC	chr7	740920	Silent	novel	L294L	0.39
OV	chr7	763834	Missense_Mutation	novel	M548R	0.25
OV	chr7	770586	Silent	NA	L633L	0.22
OV	chr7	780070	Missense_Mutation	rs747063911	S786I	0.11
OV	chr7	740835	Missense_Mutation	novel	A266D	0.18
PAAD	chr7	785728	3'UTR	novel		0.04
PAAD	chr7	763875	Missense_Mutation	novel	H562D	0.4
PAAD	chr7	756865	Silent	rs200587511	T447T	0.17
PAAD	chr7	761768	Missense_Mutation	NA	R496C	0.25
PAAD	chr7	775122	Silent	NA	G733G	0.17
PAAD	chr7	785592	Missense_Mutation	rs760802184	R836H	0.21
PAAD	chr7	754594	Missense_Mutation	novel	R344C	0.09
PCPG	chr7	763815	Missense_Mutation	novel	T542A	0.34
PRAD	chr7	756906	Missense_Mutation	NA	R461P	0.13
PRAD	chr7	785591	Missense_Mutation	rs755610202	R836C	0.41
READ	chr7	756806	Missense_Mutation	rs768679540	G428R	0.25
SARC	chr7	785592	Missense_Mutation	rs760802184	R836H	0.1
SARC	chr7	754671	Silent	rs201438122	T369T	0.73
SARC	chr7	756942	Missense_Mutation	novel	A473E	0.28
SARC	chr7	774181	Missense_Mutation	novel	V689F	0.07
SKCM	chr7	774055	Missense_Mutation	NA	P647S	0.26
SKCM	chr7	729752	Missense_Mutation	novel	E229K	0.46
SKCM	chr7	754588	Splice_Site	novel	X342_splice	0.2
SKCM	chr7	740899	Silent	novel	I287I	0.43
SKCM	chr7	740900	Missense_Mutation	NA	P288S	0.44
SKCM	chr7	740839	Silent	rs773361666	S267S	0.19
SKCM	chr7	785590	Silent	NA	H835H	0.35
SKCM	chr7	785660	3'UTR	novel		0.19
SKCM	chr7	754672	Missense_Mutation	rs200573334	D370N	0.37
SKCM	chr7	729694	Silent	rs370516537	I209I	0.25
SKCM	chr7	775122	Silent	NA	G733G	0.06
SKCM	chr7	780114	Missense_Mutation	NA	P801A	0.37
SKCM	chr7	763903	Missense_Mutation	novel	T571I	0.21
SKCM	chr7	756877	Silent	rs749145348	S451S	0.43
SKCM	chr7	756884	Silent	NA	L454L	0.06
SKCM	chr7	785711	3'UTR	novel		0.2
SKCM	chr7	763906	Missense_Mutation	rs147690117	A572V	0.03
SKCM	chr7	741346	Splice_Site	NA	X302_splice	0.32
SKCM	chr7	774117	Silent	rs766394790	G667G	0.37
SKCM	chr7	785545	Silent	NA	F820F	0.37
SKCM	chr7	785545	Silent	NA	F820F	0.25
SKCM	chr7	785546	Missense_Mutation	novel	P821S	0.25
SKCM	chr7	770576	Missense_Mutation	novel	S630F	0.19
SKCM	chr7	763938	Missense_Mutation	NA	E583K	0.39
STAD	chr7	779997	Missense_Mutation	rs377559314	A762T	0.3
STAD	chr7	785554	Silent	novel	L823L	0.42
STAD	chr7	756805	Silent	rs749052581	V427V	0.57
STAD	chr7	756826	Missense_Mutation	NA	E434D	0.15
STAD	chr7	729784	Silent	rs569560572	N239N	0.32
STAD	chr7	754700	Missense_Mutation	novel	S379L	0.39
STAD	chr7	770540	Missense_Mutation	NA	D618G	0.09
STAD	chr7	775123	Missense_Mutation	rs191515363	G734S	0.19
STAD	chr7	740830	Silent	rs113952995	A264A	0.44
STAD	chr7	774067	Missense_Mutation	NA	E651K	0.59
STAD	chr7	763910	Silent	rs374651851	S573S	0.2
STAD	chr7	770524	Silent	novel	L613L	0.08
STAD	chr7	774165	Silent	NA	A683A	0.13
STAD	chr7	763916	Silent	NA	L575L	0.22
STAD	chr7	729841	Silent	NA	V258V	0.27
STAD	chr7	741409	Missense_Mutation	novel	D323G	0.19
STAD	chr7	740868	Missense_Mutation	rs760388668	R277H	0.18
STAD	chr7	770526	Silent	rs751508824	L613L	0.52
STAD	chr7	756827	Missense_Mutation	NA	V435M	0.18
STAD	chr7	763910	Silent	rs374651851	S573S	0.11
STAD	chr7	785598	Missense_Mutation	NA	A838V	0.26
THCA	chr7	740911	Silent	NA	L291L	0.07
UCEC	chr7	775064	Missense_Mutation	rs761881360	S714L	0.31
UCEC	chr7	729742	Silent	novel	V225V	0.08
UCEC	chr7	780085	Missense_Mutation	rs774146132	Y791C	0.15
UCEC	chr7	761821	Silent	rs577043545	G513G	0.53
UCEC	chr7	756963	Missense_Mutation	novel	A480V	0.46
UCEC	chr7	770580	Silent	rs149101412	T631T	0.27
UCEC	chr7	768995	Intron	novel		0.36
UCEC	chr7	756949	Silent	rs777653988	I475I	0.18
UCEC	chr7	763964	Silent	rs185154075	V591V	0.21
UCEC	chr7	756823	Silent	novel	P433P	0.26
UCEC	chr7	785672	3'UTR	rs555419629		0.5
UCEC	chr7	740873	Missense_Mutation	rs755305361	R279C	0.48
UCEC	chr7	761821	Silent	rs577043545	G513G	0.42
UCEC	chr7	780124	Missense_Mutation	rs776149047	A804V	0.26
UCEC	chr7	754662	Silent	rs142951273	H366H	0.49
UCEC	chr7	763926	Missense_Mutation	rs769804298	A579T	0.42
UCEC	chr7	740867	Missense_Mutation	rs749838774	R277C	0.45
UCEC	chr7	775077	Silent	novel	R718R	0.1
UCEC	chr7	763906	Missense_Mutation	rs147690117	A572V	0.19
UCEC	chr7	754595	Missense_Mutation	rs200002909	R344H	0.49
UCEC	chr7	756949	Silent	rs777653988	I475I	0.26
UCEC	chr7	785536	Silent	rs142621969	S817S	0.05
UCEC	chr7	770689	Intron	novel		0.44
UCEC	chr7	763905	Missense_Mutation	rs534027051	A572T	0.16
UCEC	chr7	774193	Nonsense_Mutation	novel	E693*	0.38
UCEC	chr7	729751	Silent	novel	I228I	0.42
UCEC	chr7	768912	Intron	novel		0.75
UCEC	chr7	761796	Missense_Mutation	NA	V505A	0.39
UCEC	chr7	729799	Silent	rs751760178	D244D	0.59
UCEC	chr7	754794	Silent	rs779072395	T410T	0.33
UCEC	chr7	740874	Missense_Mutation	NA	R279H	0.22
UCEC	chr7	740923	Silent	rs202161836	N295N	0.44
UCEC	chr7	763863	Missense_Mutation	novel	L558I	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5778	0.24436
BRCA	DEL	0.1028	0.056864
DLBC	AMP	0.3333	0.13215
LGG	DEL	0.0312	0.077684
LUAD	AMP	0.4574	0.17291
OV	DEL	0.3972	3.8574e-27
SKCM	AMP	0.4823	0.00015162
STAD	AMP	0.4354	0.0078915
TGCT	AMP	0.7067	0.019484
THCA	DEL	0	0.27619
UCEC	DEL	0.115	0.00010851

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0046	Kaplan-Meier Survival Analysis
HNSC	0.00087	Kaplan-Meier Survival Analysis
SKCM	0.021	Kaplan-Meier Survival Analysis
BRCA	0.035	Kaplan-Meier Survival Analysis
KIRP	0.0037	Kaplan-Meier Survival Analysis
BLCA	0.0027	Kaplan-Meier Survival Analysis
CESC	0.0053	Kaplan-Meier Survival Analysis
GBM	0.021	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0011	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000164818 (Gene tree)
Gene ID: 54919
Gene Symbol: DNAAF5
Alias: FLJ20397|FLJ31671|FLJ39381|FLJ25564|CILD18|HEATR2
Full Name: dynein axonemal assembly factor 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 59,779 bases
Position: chr7:726,701-786,479
Accession: 26013
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is essential for the preassembly or stability of axonemal dynein arms, and is found only in organisms with motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia-18, a disorder characterized by abnormalities of motile cilia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461576	DNAAF5-206	298	-	-	- (aa)	-	-
ENST00000486546	DNAAF5-207	536	-	-	- (aa)	-	-
ENST00000403952	DNAAF5-202	1907	-	ENSP00000384884	280 (aa)	-	E9PGY2
ENST00000438961	DNAAF5-204	579	-	-	- (aa)	-	-
ENST00000437419	DNAAF5-203	585	-	ENSP00000410788	195 (aa)	-	H7C3B1
ENST00000491496	DNAAF5-208	2573	-	-	- (aa)	-	-
ENST00000297440	DNAAF5-201	3410	XM_024446813	ENSP00000297440	855 (aa)	XP_024302581	Q86Y56
ENST00000440747	DNAAF5-205	2350	-	ENSP00000403165	657 (aa)	-	H0Y650

Gene Model

Click here to download ENSG00000164818's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164818	Alzheimer Disease	5E-7	28247064
ENSG00000164818	Cerebrospinal Fluid	5E-7	28247064
ENSG00000164818	tau Proteins	5E-7	28247064

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164818	rs79057730	7	745306	G	Initial pursuit acceleration	29064472			EFO_0008434

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164818's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003341	cilium movement	21873635.	IBA	Process
GO:0003341	cilium movement	23040496.	IMP	Process
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	23040496.25232951.	IDA	Component
GO:0031514	motile cilium	23040496.25232951.	IDA	Component
GO:0036158	outer dynein arm assembly	21873635.	IBA	Process
GO:0036158	outer dynein arm assembly	23040496.25232951.	IMP	Process
GO:0036159	inner dynein arm assembly	21873635.	IBA	Process
GO:0036159	inner dynein arm assembly	25232951.	IMP	Process
GO:0045505	dynein intermediate chain binding	21873635.	IBA	Function
GO:0045505	dynein intermediate chain binding	25232951.	IPI	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.