EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26959889Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.Oncotarget2016 Mar 22Shamanna RAdoi: 10.18632/oncotarget.7906.
25468760Association Between WRN Cys1367Arg (T>C) and Cancer Risk: A Meta-analysis.Technol Cancer Res Treat2016 FebWang Bdoi: 10.1177/1533034614561359
22390926Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death.Biochem Biophys Res Commun2012 Mar 30Cheng WHdoi: 10.1016/j.bbrc.2012.02.104
17624410Role for the Werner syndrome protein in the promotion of tumor cell growth.Mech Ageing Dev2007 Jul-AugOpresko PL-
26241669A Novel WRN Frameshift Mutation Identified by Multiplex Genetic Testing in a Family with Multiple Cases of Cancer.PLoS One2015 Aug 4Yang Ldoi: 10.1371/journal.pone.0133020
22037268Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.Acta Med Okayama2011 OctWang L-
16723399Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.Proc Natl Acad Sci U S A2006 Jun 6Agrelo R-
19487340The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.Toxicol Sci2009 AugLiu FJdoi: 10.1093/toxsci/kfp104
24757718Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells.Aging Cell2014 AprLi B-
19945966Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.Carcinogenesis2010 MarFrank Bdoi: 10.1093/carcin/bgp293
21389352The Werner syndrome protein: linking the replication checkpoint response to genome stability.Aging (Albany NY)2011 MarPichierri P-
19205873A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.Breast Cancer Res Treat2009 NovWang Zdoi: 10.1007/s10549-009-0327-z
22173703Esophageal cancer risk is associated with polymorphisms of DNA repair genes MSH2 and WRN in Chinese population.J Thorac Oncol2012 FebLi Tdoi: 10.1097/JTO.0b013e31823c487a.
26690424Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.Int J Mol Sci2015 Dec 10Zins Kdoi: 10.3390/ijms161226192.
15084309The Werner syndrome protein has separable recombination and survival functions.DNA Repair (Amst)2004 May 4Swanson C-
22797812Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells.Oncol Rep2012 OctMasuda Kdoi: 10.3892/or.2012.1912

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr831083736Missense_MutationnovelY436C0.39
BLCAchr831167146SilentnovelV1369V0.21
BLCAchr831081193Missense_MutationnovelR389K0.63
BLCAchr831141528SilentnovelL1022L0.18
BLCAchr831141478Missense_MutationNAT1006P0.33
BLCAchr831087762Intronnovel0.14
BLCAchr831111791SilentNAV755V0.28
BLCAchr831167057Missense_Mutationrs747312018P1340S0.34
BLCAchr831141482Frame_Shift_InsnovelT1011Gfs*170.17
BLCAchr831090900Missense_MutationnovelS596C0.14
BLCAchr831157523SilentNAV1325V0.43
BRCAchr831065036SilentnovelV159V0.09
BRCAchr831141585Silentrs773664315C1041C0.14
BRCAchr831120314SilentNAG840G0.29
BRCAchr831076197Missense_MutationnovelM250R0.04
BRCAchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.18
BRCAchr831111786Missense_MutationNAL754V0.43
BRCAchr831076264SilentNAF272F0.46
BRCAchr831100855Missense_Mutationrs752650803T663M0.6
BRCAchr8310584085'UTRnovel0.12
BRCAchr831083764Missense_MutationNAE445D0.2
BRCAchr831085231Missense_MutationnovelE472D0.04
BRCAchr831087819Missense_MutationnovelS492Y0.09
BRCAchr831111648Missense_MutationNAS708A0.29
BRCAchr831096809Missense_MutationNAS647L0.34
BRCAchr831124911SilentNAI912I0.32
BRCAchr8311731033'UTRnovel0.06
CESCchr831111796Missense_MutationNAT757R0.29
CESCchr831058539Frame_Shift_DelnovelR31Kfs*170.24
CESCchr831141693Frame_Shift_DelnovelL1051Ffs*480.18
CESCchr831154719SilentNAI1261I0.18
COADchr831059228Missense_Mutationrs773803207D58N0.34
COADchr831147471Missense_MutationnovelK1189N0.28
COADchr8310584045'UTRnovel0.31
COADchr831087874Missense_Mutationrs149565907E510D0.08
COADchr831150354Nonsense_MutationNAE1196*0.41
COADchr831167042Missense_MutationNAI1335V0.12
COADchr831065030SilentnovelN157N0.41
COADchr831157445Frame_Shift_DelnovelD1302Ifs*70.24
COADchr8310584145'UTRnovel0.26
COADchr831116467Missense_Mutationrs779140898A796V0.2
COADchr831067139Missense_MutationnovelP204H0.06HRDC
COADchr831120390Missense_Mutationrs776463866V866I0.31
COADchr831059186Missense_MutationnovelL44I0.05
COADchr831111655Missense_MutationNAI710T0.25
COADchr831065061Missense_MutationnovelK168Q0.09HRDC
COADchr831154707Silentrs777616472Q1257Q0.08
COADchr831132462Missense_MutationNAE975K0.18
COADchr831120268Missense_MutationNAG825A0.28
COADchr831087860In_Frame_InsNAE510dup0.3
COADchr831120427Splice_Regionrs7471150980.47
COADchr831080880Missense_MutationNAL285V0.2
ESCAchr831064418Silentrs374898432H113H0.25
ESCAchr831124608Missense_MutationnovelS906T0.19
ESCAchr831088912Silentrs757279675N533N0.24
ESCAchr831120350SilentnovelI852I0.11
ESCAchr831064926Missense_MutationnovelG123R0.49HRDC
ESCAchr831154727Missense_MutationnovelS1264C0.39
GBMchr831154688Missense_MutationnovelK1251T0.45
GBMchr831167106Missense_MutationnovelK1356T0.05
GBMchr831065032Missense_MutationnovelF158S0.11HRDC
HNSCchr831173002Missense_MutationnovelS1400F0.17
HNSCchr831091844Missense_MutationnovelP615L0.12
HNSCchr831067143SilentnovelL205L0.67
HNSCchr831120345Nonsense_MutationnovelE851*0.15
HNSCchr831067115Frame_Shift_DelnovelR196Pfs*320.4HRDC
HNSCchr831100933Frame_Shift_DelnovelL690*0.52
HNSCchr831120326Missense_MutationnovelD844E0.32
HNSCchr831083720Missense_MutationnovelE431K0.15
HNSCchr831154711Missense_MutationnovelM1259V0.06
KIRCchr831081202Frame_Shift_InsnovelM393Dfs*90.06
KIRCchr831081203Frame_Shift_InsnovelM393Lfs*100.06
KIRCchr831120361Missense_MutationNAG856D0.26
KIRPchr831081051Missense_Mutationrs764559021V342I0.23
LAMLchr831147417Missense_MutationnovelM1171I0.3
LGGchr831081248Silentrs758386387Q407Q0.09
LGGchr831065005Missense_Mutationrs61761625R149H0.41HRDC
LGGchr831080886Missense_MutationnovelD287Y0.26
LGGchr831087784Missense_MutationnovelE480D0.33
LGGchr831116471SilentNAG797G0.38
LGGchr831088919Missense_MutationnovelQ536E0.4
LIHCchr8311733613'UTRnovel0.33
LIHCchr831173033Nonsense_MutationNAW1410*0.47
LIHCchr831083775Splice_SitenovelX449_splice0.07
LIHCchr831116489Missense_MutationnovelR803S0.18
LIHCchr831147412Missense_MutationnovelK1170E0.29
LUADchr831096825SilentNAL652L0.32
LUADchr831120397Missense_MutationNAW868L0.12
LUADchr831173091Missense_MutationNAL1430V0.76
LUADchr831081291Missense_MutationnovelT422S0.14
LUADchr831090488Missense_MutationnovelS559L0.06
LUADchr831080874Missense_MutationNAI283F1
LUADchr831173088Missense_MutationnovelG1429C0.19
LUADchr831167117Missense_MutationnovelD1360H0.06
LUADchr831120286Missense_MutationNAA831V0.32
LUADchr831157456Missense_MutationnovelL1303S0.55
LUADchr831120319Missense_MutationNAP842L0.17
LUADchr831096770Missense_MutationnovelG634V0.24
LUADchr831067164SilentNAY212Y0.11
LUADchr831141749Missense_MutationNAL1069F0.2
LUADchr831064343Missense_MutationNAL88F0.25HRDC
LUADchr831116517Missense_MutationnovelD813Y0.67
LUADchr831141586Missense_MutationNAA1042P0.25
LUADchr831080898Missense_MutationnovelN291Y0.25
LUADchr831076193Missense_Mutationrs758055295D249N0.37
LUADchr831100856Silentrs201982706T663T0.52
LUADchr831081011SilentNAV328V0.15
LUADchr831067145Missense_MutationNAT206I0.08HRDC
LUSCchr831058543Frame_Shift_Delrs7558910460.29
LUSCchr831064333Missense_MutationNAW85L0.3HRDC
LUSCchr831111613Splice_SitenovelX697_splice0.31
LUSCchr831116466Missense_MutationnovelA796T0.27
LUSCchr831058543Missense_MutationNAK32N0.61
LUSCchr831157520Silentrs370253199P1324P0.45
LUSCchr831111696Missense_MutationnovelQ724E0.13
LUSCchr831157487Missense_MutationNAQ1313H0.51
LUSCchr831167107SilentNAK1356K0.4
LUSCchr831141569Missense_Mutationrs773176431K1036R0.18
LUSCchr831059211Missense_MutationnovelS52F0.1
LUSCchr831167117Missense_MutationnovelD1360Y0.32
LUSCchr831058452Missense_MutationnovelS2I0.17
LUSCchr831081023Missense_MutationnovelQ332H0.1
OVchr831085221Missense_MutationNAE469G0.16
OVchr831067159Missense_MutationNAL211V0.25HRDC
OVchr831141563Missense_Mutationrs200370409Y1034F0.25
OVchr831091893Missense_MutationNAI631M0.66
OVchr831100931SilentnovelG688G0.05
OVchr831116503Missense_MutationnovelH808L0.61
OVchr831064292Missense_MutationnovelM71I0.07HRDC
PAADchr831067114Missense_Mutationrs375762379R196C0.15HRDC
PRADchr831157509SilentnovelR1321R0.08
PRADchr831100898Silentrs776209945G677G0.29
READchr831147396Missense_MutationnovelR1164S0.08
READchr831141590Missense_MutationnovelL1043P0.08
READchr831081039Missense_Mutationrs759046519V338I0.38
READchr831083748Missense_MutationNAS440N0.28
READchr831085165Splice_SitenovelX451_splice0.37
READchr831090499Nonsense_MutationnovelE563*0.43
SARCchr831157442SilentnovelG1298G0.33
SARCchr831080881Missense_MutationnovelL285R0.47
SARCchr831087912Frame_Shift_InsnovelD524*0.12
SARCchr831087913Frame_Shift_InsnovelD524Vfs*130.12
SKCMchr831141582SilentNAI1040I0.19
SKCMchr831081093Missense_MutationNAK356E0.4
SKCMchr831059248SilentnovelF64F0.29
SKCMchr831059233SilentnovelA59A0.61
SKCMchr831116356Missense_MutationNAS759F0.24
SKCMchr831090904SilentNAP597P0.15
SKCMchr831081040Missense_MutationNAV338G0.62
SKCMchr831090898SilentNAI595I0.18
SKCMchr831141519SilentNAS1019S0.36
SKCMchr831080981Missense_MutationnovelL318F0.21
SKCMchr831157509Nonsense_MutationNAR1321*0.23
SKCMchr831111742Missense_MutationNAV739A0.26
SKCMchr831141768SilentNAL1076L0.44
SKCMchr831157520Silentrs370253199P1324P0.35
SKCMchr831067070Missense_Mutationrs774751582V181A0.47HRDC
SKCMchr831080995Missense_Mutationrs369277330S323L0.6
SKCMchr831167182SilentNAI1381I0.4
SKCMchr831090834Missense_MutationnovelG574E0.39
SKCMchr831141729Missense_MutationNAL1063F0.31
SKCMchr831090857Nonsense_Mutationrs757808169Q582*0.2
SKCMchr831067138Missense_Mutationrs199644081P204S0.27HRDC
SKCMchr831090900Missense_MutationnovelS596F0.46
SKCMchr831157423Missense_MutationNAS1292F0.6
SKCMchr831142676Missense_Mutationrs746470648P1095L0.39
SKCMchr831167172Missense_MutationNAS1378F0.29
SKCMchr831100897Missense_MutationNAG677A0.29
SKCMchr8310583795'UTRnovel0.67
SKCMchr831141427Splice_Regionnovel0.61
SKCMchr831111760Missense_MutationNAN745S0.52
SKCMchr831124963Missense_MutationNAM930V0.23
SKCMchr831067109Missense_Mutationrs776831463S194F0.39HRDC
SKCMchr831085201SilentnovelS462S0.27
STADchr831068277Missense_Mutationrs62506077R225Q0.15HRDC
STADchr831081132Nonsense_Mutationrs17847577R369*0.69
STADchr831111650SilentNAS708S0.16
STADchr831124542Missense_Mutationrs771294955R884H0.18
STADchr831120391Missense_MutationNAV866G0.15
STADchr831067146SilentNAT206T0.64
STADchr831141594Silentrs775952540T1044T0.15
STADchr831120419SilentnovelL875L0.28
STADchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.26
STADchr831111624Missense_MutationNAV700I0.27
STADchr831087874Missense_Mutationrs149565907E510D0.18
STADchr831091899Splice_SiteNAX633_splice0.28
STADchr831090872Missense_MutationnovelY587H0.1
STADchr831150360Missense_MutationnovelV1198L0.21
STADchr831067146SilentNAT206T0.08
STADchr831124557Missense_Mutationrs374262282R889Q0.23
STADchr831111765Missense_MutationNAL747I0.24
STADchr831081172Missense_MutationNAK382T0.1
STADchr831141594Silentrs775952540T1044T0.18
STADchr831120314SilentNAG840G0.13
STADchr831157429Missense_Mutationrs146861737A1294V0.09
STADchr831058454Frame_Shift_InsNAL6Ifs*120.41
STADchr831100856Silentrs201982706T663T0.19
TGCTchr831081206Missense_MutationnovelM393I0.12
THCAchr831173081Nonsense_MutationnovelR1427*0.08
THCAchr831147437Missense_MutationNAL1178P0.4
UCECchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.31
UCECchr831150456Splice_SitenovelX1229_splice0.22
UCECchr831085219Missense_MutationnovelD468E0.33
UCECchr831081036Nonsense_MutationNAE337*0.32
UCECchr831058539Missense_MutationNAR31I0.3
UCECchr8311733163'UTRnovel0.27
UCECchr831142629Silentrs11574345S1079S0.17
UCECchr831087786Missense_MutationnovelN481S0.09
UCECchr831132376Missense_MutationnovelC946Y0.48
UCECchr831087874Missense_Mutationrs149565907E510D0.28
UCECchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.34
UCECchr831143570Nonsense_MutationnovelY1110*0.38
UCECchr831120316Missense_Mutationrs755249893A841V0.36
UCECchr831081159Missense_MutationNAV378L0.2
UCECchr831080869Missense_MutationnovelV281A0.43
UCECchr831058485Missense_MutationNAR13Q0.18
UCECchr831141440Missense_Mutationrs370713742R993H0.22
UCECchr831141758Missense_MutationNAK1072N0.26
UCECchr831116449Missense_MutationnovelS790F0.18
UCECchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.57
UCECchr831096790Missense_MutationNAV641L0.07
UCECchr8310584035'UTRnovel0.37
UCECchr831081138Nonsense_MutationnovelE371*0.46
UCECchr831116520Nonsense_MutationnovelE814*0.26
UCECchr831059187Frame_Shift_InsnovelF46Lfs*110.33
UCECchr831120405Missense_MutationnovelA871T0.24
UCECchr831173011Missense_MutationnovelR1403K0.36
UCECchr831081069Missense_MutationnovelD348N0.33
UCECchr831083731Silentrs374140086T434T0.37
UCECchr831081172Missense_Mutationrs541455377K382R0.12
UCECchr831087896Nonsense_MutationnovelE518*0.39
UCECchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.31
UCECchr831111721Missense_Mutationrs777084325R732Q0.24
UCECchr831064351Missense_MutationnovelR91I0.28HRDC
UCECchr831124942Missense_MutationnovelQ923K0.65
UCECchr831167021Splice_Siters752465293X1328_splice0.53
UCECchr831083731Silentrs374140086T434T0.47
UCECchr831087863Nonsense_MutationnovelE507*0.48
UCECchr831067172Frame_Shift_InsnovelD216Lfs*130.12HRDC
UCECchr831076178Nonsense_MutationNAE244*0.3
UCECchr831088940Missense_MutationnovelY543H0.45
UCECchr831132462Missense_MutationNAE975K0.4
UCECchr831141758Missense_MutationNAK1072N0.23
UCECchr831120365Silentrs3087432R857R0.33
UCECchr831147087Missense_MutationnovelS1140P0.3
UCECchr831087673Intronnovel0.27
UCECchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.51
UCECchr831132462Missense_MutationNAE975K0.21
UCECchr831132365Missense_MutationnovelR942S0.41
UCECchr831167083Silentrs763768734I1348I0.36
UCECchr831120311Silentrs779314628Y839Y0.38
UCECchr831087701Intronnovel0.17
UCECchr831067120Missense_MutationnovelS198R0.3HRDC
UCECchr831058513Missense_MutationnovelQ22H0.5
UCECchr831173060Missense_MutationnovelK1419N0.15
UCECchr831132462Missense_MutationNAE975K0.4
UCECchr831111721Missense_Mutationrs777084325R732Q0.23
UCECchr831087664Intronnovel0.3
UCECchr831167160Missense_MutationNAC1374F0.3
UCECchr831065062Nonsense_MutationnovelK168delinsNEM*RYQPDM0.07HRDC
UCECchr831142674SilentnovelV1094V0.05
UCECchr831147119SilentnovelQ1150Q0.36
UCECchr831059228Missense_MutationnovelD58H0.47
UCECchr831087905Nonsense_MutationNAE521*0.54
UCECchr831132432Missense_Mutationrs769143572K965E0.39
UCECchr8311732343'UTRnovel0.21
UCECchr831100856Silentrs201982706T663T0.23
UCECchr831143616Frame_Shift_Delrs778872619S1128Vfs*340.5
UCECchr831167157Missense_MutationnovelR1373I0.11
UCECchr831132373Missense_MutationNAH945R0.04
UCECchr831065063Missense_MutationnovelK168N0.21HRDC
UCECchr831081247Missense_MutationnovelQ407P0.19
UCECchr831111753Missense_MutationnovelT743P0.4
UCECchr831116468SilentnovelA796A0.2
UCECchr831100890Missense_Mutationrs758232075E675Q0.31
UCECchr831081051Missense_Mutationrs764559021V342I0.58
UCECchr831065019Missense_MutationNAK154E0.32HRDC
UCECchr831116506Missense_MutationNAR809M0.28
UCECchr831058454Frame_Shift_InsNAL6Ifs*120.42
UCECchr831096838Nonsense_MutationnovelE657*0.47
UCECchr831100869Missense_MutationnovelD668N0.29
UCECchr831124557Missense_Mutationrs374262282R889Q0.33
UCSchr831087664Intronnovel0.25
UCSchr831067085Missense_MutationnovelG186V1HRDC
UCSchr831132455Missense_MutationnovelI972M0.2

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.53194.5185e-08
DLBCDEL0.18750.15679
ESCADEL0.38040.060925
PAADDEL0.21740.050455
READDEL0.52730.20625

Survival Analysis
CancerP-value Q-value
THYM0.041

Kaplan-Meier Survival Analysis

KIRC0.016

Kaplan-Meier Survival Analysis

MESO0.005

Kaplan-Meier Survival Analysis

SKCM0.019

Kaplan-Meier Survival Analysis

KIRP0.0053

Kaplan-Meier Survival Analysis

COAD0.012

Kaplan-Meier Survival Analysis

READ0.00062

Kaplan-Meier Survival Analysis

LAML0.00025

Kaplan-Meier Survival Analysis

KICH0.0049

Kaplan-Meier Survival Analysis

LIHC0.002

Kaplan-Meier Survival Analysis

LGG0.00046

Kaplan-Meier Survival Analysis

THCA0.022

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • PRI
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000165392 (Gene tree)
Gene ID
7486
Gene Symbol
WRN
Alias
RECQL2|RECQ3
Full Name
Werner syndrome RecQ like helicase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
140,508 bases
Position
chr8:31,033,262-31,173,769
Accession
12791
RBP type
canonical RBP
Summary
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000298139HRDCPF00570.231.5e-1111
ENSP00000298139DEADPF00270.293.5e-1511
ENSP00000298139DNA_pol_A_exo1PF01612.201.2e-3511
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000298139WRN-2015215XM_011544639ENSP000002981391432 (aa)XP_011542941Q14191
ENST00000520169WRN-202629--- (aa)--
ENST00000521620WRN-2033593--- (aa)--
Gene Model
Click here to download ENSG00000165392's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000165392Exercise Test6.31966375083062E-617903301
ENSG00000165392Iron2.8850000E-00419880490
ENSG00000165392Iron3.1610000E-00419880490
ENSG00000165392Iron9.2310000E-00419880490
ENSG00000165392Iron8.2240000E-00419880490
ENSG00000165392Iron6.7920000E-00419880490
ENSG00000165392Waist-Hip Ratio7.8790000E-005-
ENSG00000165392Waist-Hip Ratio9.2880000E-005-
ENSG00000165392Angiotensin-Converting Enzyme Inhibitors2E-628084903
ENSG00000165392Cough2E-628084903
ENSG00000165392Immunoglobulins3E-623382691
ENSG00000165392Longevity6E-825918517
ENSG00000165392Immunoglobulins1E-623382691
ENSG00000165392Exercise Test6E-617903301
ENSG00000165392Immunoglobulins1E-623382691
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000165392rs10954779831162081TIntelligence (MTAG)29326435[0.011-0.023] unit decrease0.017427584EFO_0004337
ENSG00000165392rs2737339831155954ACognitive performance30038396[0.013-0.024] unit decrease0.0183EFO_0008354
ENSG00000165392rs62506104831162492AEducational attainment (MTAG)30038396[0.006-0.0126] unit decrease0.0093EFO_0004784
ENSG00000165392rs2553268831078840?Exercise treadmill test traits17903301EFO_0004328
ENSG00000165392rs11574358831147066?Lifespan25918517[NR] unit increase5.584EFO_0004300
ENSG00000165392rs117173564831153953?Cough in response to angiotensin-converting enzyme inhibitor drugs28084903[2.88-12.82]6.07EFO_0005325|HP_0012735
ENSG00000165392rs2737339831155954ACognitive performance (MTAG)30038396[0.013-0.022] unit decrease0.0177EFO_0008354
ENSG00000165392rs16877794831158766?General cognitive ability29844566z-score increase5.212EFO_0004337
ENSG00000165392rs10954779831162081TIntelligence29942086z-score decrease5.93EFO_0004337
ENSG00000165392rs41520844831135670?Adolescent idiopathic scoliosis30019117EFO_0005423
ENSG00000165392rs62506074831048573TEducational attainment (years of education)30038396[0.0062-0.012] unit increase0.0091EFO_0004784
ENSG00000165392rs62506104831162492AEducational attainment (years of education)30038396[0.0063-0.0133] unit decrease0.0098EFO_0004784
ENSG00000165392rs1800389831067041?Cardiovascular disease30595370EFO_0000319
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165392's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000165392WRN8169.805ENSAMEG00000000475-10069.237Ailuropoda_melanoleuca
ENSG00000165392WRN9255.049ENSAPLG00000001616WRN9155.348Anas_platyrhynchos
ENSG00000165392WRN9450.515ENSACAG00000003109WRN9950.662Anolis_carolinensis
ENSG00000165392WRN10085.625ENSANAG00000032806WRN9989.774Aotus_nancymaae
ENSG00000165392WRN9447.549ENSAMXG00000010066wrn8946.896Astyanax_mexicanus
ENSG00000165392WRN10072.292ENSBTAG00000021592WRN10072.292Bos_taurus
ENSG00000165392WRN5831.573WBGene00006944wrn-17132.449Caenorhabditis_elegans
ENSG00000165392WRN10088.494ENSCJAG00000012511WRN10088.773Callithrix_jacchus
ENSG00000165392WRN10072.207ENSCAFG00000006410WRN9971.551Canis_familiaris
ENSG00000165392WRN10073.943ENSCAFG00020001236WRN10074.030Canis_lupus_dingo
ENSG00000165392WRN10072.083ENSCHIG00000014991WRN10072.083Capra_hircus
ENSG00000165392WRN9978.457ENSTSYG00000012689WRN9978.596Carlito_syrichta
ENSG00000165392WRN9655.081ENSCAPG00000016803WRN9870.882Cavia_aperea
ENSG00000165392WRN9970.926ENSCPOG00000002943WRN9970.791Cavia_porcellus
ENSG00000165392WRN10087.997ENSCCAG00000023793WRN10088.276Cebus_capucinus
ENSG00000165392WRN10091.207ENSCATG00000040557WRN10092.463Cercocebus_atys
ENSG00000165392WRN9874.501ENSCLAG00000000817WRN10071.218Chinchilla_lanigera
ENSG00000165392WRN9693.827ENSCSAG00000015810WRN9993.966Chlorocebus_sabaeus
ENSG00000165392WRN8087.151ENSCHOG00000008966WRN8187.151Choloepus_hoffmanni
ENSG00000165392WRN9558.974ENSCPBG00000013421WRN9059.151Chrysemys_picta_bellii
ENSG00000165392WRN6437.846ENSCING00000002232-7937.871Ciona_intestinalis
ENSG00000165392WRN10093.510ENSCANG00000037137WRN10093.022Colobus_angolensis_palliatus
ENSG00000165392WRN9971.110ENSCGRG00001016491Wrn10071.110Cricetulus_griseus_chok1gshd
ENSG00000165392WRN8369.891ENSCGRG00000016821Wrn10069.891Cricetulus_griseus_crigri
ENSG00000165392WRN9447.237ENSDARG00000098211wrn8946.951Danio_rerio
ENSG00000165392WRN9571.418ENSDNOG00000008481WRN10071.489Dasypus_novemcinctus
ENSG00000165392WRN9971.399ENSDORG00000002696Wrn10071.360Dipodomys_ordii
ENSG00000165392WRN7780.676ENSETEG00000019854WRN7980.676Echinops_telfairi
ENSG00000165392WRN9870.526ENSEASG00005016813WRN9880.986Equus_asinus_asinus
ENSG00000165392WRN10071.968ENSECAG00000000110WRN10072.035Equus_caballus
ENSG00000165392WRN8564.789ENSEEUG00000004926WRN9564.789Erinaceus_europaeus
ENSG00000165392WRN9447.123ENSELUG00000017817wrn9453.271Esox_lucius
ENSG00000165392WRN10073.093ENSFCAG00000024759WRN10072.935Felis_catus
ENSG00000165392WRN10073.681ENSFDAG00000008637WRN10073.342Fukomys_damarensis
ENSG00000165392WRN9953.664ENSGALG00000040909WRN9253.664Gallus_gallus
ENSG00000165392WRN9955.608ENSGAGG00000022647WRN9955.571Gopherus_agassizii
ENSG00000165392WRN10096.718ENSGGOG00000022154WRN10096.718Gorilla_gorilla
ENSG00000165392WRN9973.989ENSHGLG00000003638WRN10073.162Heterocephalus_glaber_female
ENSG00000165392WRN9447.985ENSIPUG00000002090wrn9247.935Ictalurus_punctatus
ENSG00000165392WRN10074.797ENSSTOG00000013599WRN10074.459Ictidomys_tridecemlineatus
ENSG00000165392WRN9969.714ENSJJAG00000015655Wrn10069.574Jaculus_jaculus
ENSG00000165392WRN9749.929ENSLACG00000001569-9350.071Latimeria_chalumnae
ENSG00000165392WRN9551.055ENSLOCG00000010792wrn9350.000Lepisosteus_oculatus
ENSG00000165392WRN9974.654ENSLAFG00000004434WRN10074.654Loxodonta_africana
ENSG00000165392WRN9992.647ENSMFAG00000043428WRN9993.557Macaca_fascicularis
ENSG00000165392WRN10092.394ENSMMUG00000022655WRN10093.301Macaca_mulatta
ENSG00000165392WRN10093.719ENSMNEG00000032617WRN10093.999Macaca_nemestrina
ENSG00000165392WRN10092.184ENSMLEG00000038296WRN10092.463Mandrillus_leucophaeus
ENSG00000165392WRN9454.978ENSMGAG00000004960WRN8854.792Meleagris_gallopavo
ENSG00000165392WRN9971.179ENSMAUG00000016235Wrn10071.179Mesocricetus_auratus
ENSG00000165392WRN9974.478ENSMICG00000010630WRN10074.983Microcebus_murinus
ENSG00000165392WRN9970.133ENSMOCG00000013972Wrn10070.063Microtus_ochrogaster
ENSG00000165392WRN10055.163ENSMODG00000018997WRN10055.532Monodelphis_domestica
ENSG00000165392WRN9969.805MGP_CAROLIEiJ_G0030961Wrn10069.526Mus_caroli
ENSG00000165392WRN9970.014ENSMUSG00000031583Wrn10069.735Mus_musculus
ENSG00000165392WRN9969.526MGP_PahariEiJ_G0021430Wrn10069.247Mus_pahari
ENSG00000165392WRN9970.223MGP_SPRETEiJ_G0032079Wrn10069.944Mus_spretus
ENSG00000165392WRN10073.162ENSMPUG00000010201WRN10073.162Mustela_putorius_furo
ENSG00000165392WRN9975.785ENSMLUG00000005863WRN9975.785Myotis_lucifugus
ENSG00000165392WRN9972.176ENSNGAG00000018413Wrn9972.176Nannospalax_galili
ENSG00000165392WRN10096.371ENSNLEG00000012006WRN10096.371Nomascus_leucogenys
ENSG00000165392WRN7363.755ENSMEUG00000008271-7663.478Notamacropus_eugenii
ENSG00000165392WRN8963.994ENSOPRG00000001480WRN8863.893Ochotona_princeps
ENSG00000165392WRN9973.449ENSODEG00000004076WRN10073.101Octodon_degus
ENSG00000165392WRN8961.479ENSOANG00000005952-9361.479Ornithorhynchus_anatinus
ENSG00000165392WRN10075.554ENSOCUG00000012620WRN9075.798Oryctolagus_cuniculus
ENSG00000165392WRN9773.714ENSOGAG00000009600WRN10073.714Otolemur_garnettii
ENSG00000165392WRN10072.222ENSOARG00000000163WRN10072.222Ovis_aries
ENSG00000165392WRN10096.718ENSPPAG00000036871WRN10096.718Pan_paniscus
ENSG00000165392WRN10074.254ENSPPRG00000010928WRN10074.046Panthera_pardus
ENSG00000165392WRN10074.046ENSPTIG00000020609WRN10073.838Panthera_tigris_altaica
ENSG00000165392WRN10098.394ENSPTRG00000020145WRN10098.394Pan_troglodytes
ENSG00000165392WRN10092.817ENSPANG00000018594WRN10093.445Papio_anubis
ENSG00000165392WRN7067.262ENSPKIG00000025497wrn9360.039Paramormyrops_kingsleyae
ENSG00000165392WRN9457.768ENSPSIG00000013411WRN8958.284Pelodiscus_sinensis
ENSG00000165392WRN9969.784ENSPEMG00000020615Wrn9970.118Peromyscus_maniculatus_bairdii
ENSG00000165392WRN9755.713ENSPCIG00000020146WRN9956.407Phascolarctos_cinereus
ENSG00000165392WRN10096.439ENSPPYG00000018494WRN10096.439Pongo_abelii
ENSG00000165392WRN8870.690ENSPCAG00000013763WRN8870.690Procavia_capensis
ENSG00000165392WRN7966.824ENSPCOG00000012938WRN9866.667Propithecus_coquereli
ENSG00000165392WRN9674.257ENSPVAG00000012909WRN9674.257Pteropus_vampyrus
ENSG00000165392WRN9446.998ENSPNAG00000021848wrn8846.998Pygocentrus_nattereri
ENSG00000165392WRN9969.225ENSRNOG00000015440Wrn10069.156Rattus_norvegicus
ENSG00000165392WRN10090.021ENSRBIG00000031825WRN10090.902Rhinopithecus_bieti
ENSG00000165392WRN10093.231ENSRROG00000045381WRN10093.440Rhinopithecus_roxellana
ENSG00000165392WRN10088.904ENSSBOG00000027238WRN10088.555Saimiri_boliviensis_boliviensis
ENSG00000165392WRN9957.626ENSSHAG00000005577WRN9957.833Sarcophilus_harrisii
ENSG00000165392WRN9548.148ENSSFOG00015006123wrn9547.962Scleropages_formosus
ENSG00000165392WRN7465.368ENSSARG00000006157WRN8765.368Sorex_araneus
ENSG00000165392WRN9776.450ENSSSCG00000015840WRN10076.450Sus_scrofa
ENSG00000165392WRN7257.336ENSTGUG00000001765WRN10057.336Taeniopygia_guttata
ENSG00000165392WRN7862.372ENSTBEG00000012702-7862.030Tupaia_belangeri
ENSG00000165392WRN10070.744ENSTTRG00000012302WRN10070.151Tursiops_truncatus
ENSG00000165392WRN10071.221ENSUAMG00000021324WRN10071.498Ursus_americanus
ENSG00000165392WRN8671.637ENSUMAG00000007159WRN9771.961Ursus_maritimus
ENSG00000165392WRN9971.329ENSVPAG00000011004WRN9971.329Vicugna_pacos
ENSG00000165392WRN10072.005ENSVVUG00000019867WRN10072.091Vulpes_vulpes
ENSG00000165392WRN9852.572ENSXETG00000018302wrn9953.834Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000287magnesium ion binding21873635.IBAFunction
GO:0000287magnesium ion binding16622405.IDAFunction
GO:0000400four-way junction DNA binding21873635.IBAFunction
GO:0000400four-way junction DNA binding11735402.IDAFunction
GO:0000403Y-form DNA binding21873635.IBAFunction
GO:0000403Y-form DNA binding11735402.17715146.26420422.IDAFunction
GO:0000405bubble DNA binding21873635.IBAFunction
GO:0000405bubble DNA binding11433031.11735402.IDAFunction
GO:0000723telomere maintenance18212065.IMPProcess
GO:0000723telomere maintenance25801465.TASProcess
GO:0000724double-strand break repair via homologous recombination21873635.IBAProcess
GO:0000731DNA synthesis involved in DNA repair21873635.IBAProcess
GO:0000731DNA synthesis involved in DNA repair17563354.IDAProcess
GO:0000781chromosome, telomeric region21873635.IBAComponent
GO:0000781chromosome, telomeric region15200954.26420422.IDAComponent
GO:0001302replicative cell aging21873635.IBAProcess
GO:0003677DNA binding21873635.IBAFunction
GO:0003677DNA binding9288107.IDAFunction
GO:0003678DNA helicase activity12944467.19734539.26420422.IDAFunction
GO:0003678DNA helicase activity10871376.IMPFunction
GO:0003682chromatin binding21873635.IBAFunction
GO:0004003ATP-dependent DNA helicase activity9288107.15200954.IDAFunction
GO:0004386helicase activity12181313.IDAFunction
GO:0004527exonuclease activity12944467.IDAFunction
GO:0004527exonuclease activity15200954.IMPFunction
GO:0005515protein binding10373438.10783163.11328876.11427532.11598021.11919194.12181313.12750383.14596914.14657243.14688284.14734561.15735006.15965237.16030011.17498979.17611195.17715146.17961633.18203716.19343720.21639834.24126761.25931448.26496610.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm21873635.IBAComponent
GO:0005654nucleoplasm11420665.12944467.17498979.21639834.25801465.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005657replication fork21873635.IBAComponent
GO:0005657replication fork-ISSComponent
GO:0005662DNA replication factor A complex21873635.IBAComponent
GO:0005694chromosome21873635.IBAComponent
GO:0005730nucleolus9618508.11420665.12181313.12944467.15200954.17498979.21639834.25801465.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005813centrosome21873635.IBAComponent
GO:0005813centrosome17498979.IDAComponent
GO:0006259DNA metabolic process16622405.IDAProcess
GO:0006260DNA replication12882351.IMPProcess
GO:0006260DNA replication-ISSProcess
GO:0006260DNA replication-TASProcess
GO:0006281DNA repair21873635.IBAProcess
GO:0006284base-excision repair21873635.IBAProcess
GO:0006284base-excision repair17611195.IDAProcess
GO:0006302double-strand break repair21639834.IMPProcess
GO:0006310DNA recombination21873635.IBAProcess
GO:0006974cellular response to DNA damage stimulus18203716.IDAProcess
GO:0006979response to oxidative stress21873635.IBAProcess
GO:0006979response to oxidative stress17611195.IDAProcess
GO:0007420brain development-IEAProcess
GO:0007568aging9288107.NASProcess
GO:0007569cell aging21873635.IBAProcess
GO:0007569cell aging18212065.IMPProcess
GO:0008340determination of adult lifespan21873635.IBAProcess
GO:00084083'-5' exonuclease activity21873635.IBAFunction
GO:00084083'-5' exonuclease activity10783163.10871373.12181313.16622405.IDAFunction
GO:0009267cellular response to starvation21873635.IBAProcess
GO:0009267cellular response to starvation11420665.IDAProcess
GO:0009378four-way junction helicase activity21873635.IBAFunction
GO:0009378four-way junction helicase activity11433031.11735402.IDAFunction
GO:0010225response to UV-C21873635.IBAProcess
GO:0010225response to UV-C17563354.IDAProcess
GO:0010259multicellular organism aging21873635.IBAProcess
GO:0010259multicellular organism aging16673358.IMPProcess
GO:0016607nuclear speck-IDAComponent
GO:0016887ATPase activity10373438.10871376.IDAFunction
GO:0030145manganese ion binding21873635.IBAFunction
GO:0030145manganese ion binding16622405.IDAFunction
GO:0031297replication fork processing21873635.IBAProcess
GO:0031297replication fork processing17115688.IDAProcess
GO:0031297replication fork processing12882351.IMPProcess
GO:0032405MutLalpha complex binding17715146.IDAFunction
GO:0032508DNA duplex unwinding21873635.IBAProcess
GO:0032508DNA duplex unwinding11735402.26420422.IDAProcess
GO:0035861site of double-strand break21873635.IBAComponent
GO:0040009regulation of growth rate-IEAProcess
GO:0042803protein homodimerization activity21873635.IBAFunction
GO:0042803protein homodimerization activity10783163.IDAFunction
GO:0042981regulation of apoptotic process21873635.IBAProcess
GO:0042981regulation of apoptotic process9681877.IGIProcess
GO:0043005neuron projection-IEAComponent
GO:00431383'-5' DNA helicase activity17715146.IDAFunction
GO:0043140ATP-dependent 3'-5' DNA helicase activity21873635.IBAFunction
GO:0044806G-quadruplex DNA unwinding21873635.IBAProcess
GO:0044806G-quadruplex DNA unwinding11735402.IDAProcess
GO:0044806G-quadruplex DNA unwinding-ISSProcess
GO:0044877protein-containing complex binding21873635.IBAFunction
GO:0044877protein-containing complex binding10783163.IDAFunction
GO:0051345positive regulation of hydrolase activity21873635.IBAProcess
GO:0051345positive regulation of hydrolase activity17611195.IDAProcess
GO:0051880G-quadruplex DNA binding11433031.11735402.IDAFunction
GO:0061749forked DNA-dependent helicase activity21873635.IBAFunction
GO:0061749forked DNA-dependent helicase activity11735402.IDAFunction
GO:0061820telomeric D-loop disassembly21873635.IBAProcess
GO:0061820telomeric D-loop disassembly15200954.19734539.26420422.IDAProcess
GO:0061820telomeric D-loop disassembly22039056.IGIProcess
GO:0061820telomeric D-loop disassembly22039056.TASProcess
GO:0061821telomeric D-loop binding21873635.IBAFunction
GO:0061821telomeric D-loop binding19734539.26420422.IDAFunction
GO:0061849telomeric G-quadruplex DNA binding19734539.ICFunction
GO:00703373'-flap-structured DNA binding21873635.IBAFunction
GO:00703373'-flap-structured DNA binding26420422.IDAFunction
GO:0071480cellular response to gamma radiation21873635.IBAProcess
GO:0071480cellular response to gamma radiation21639834.IDAProcess
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEAProcess
GO:0090656t-circle formation27918544.TASProcess
GO:0098530positive regulation of strand invasion21873635.IBAProcess
GO:0098530positive regulation of strand invasion26420422.IDAProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
GO:1902570protein localization to nucleolus11420665.IDAProcess
GO:19057738-hydroxy-2'-deoxyguanosine DNA binding21873635.IBAFunction
GO:19057738-hydroxy-2'-deoxyguanosine DNA binding19734539.IDAFunction
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us