EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20671611Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.Med Sci Monit2010 AugWang Z-
24769442API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.Cancer Res2014 Jul 1Noh KHdoi: 10.1158/0008-5472.CAN-13-3225
25070070Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer.BMC Cancer2014 Jul 28Cho Hdoi: 10.1186/1471-2407-14-545.
25248562Apoptosis Inhibitor 5 Increases Metastasis via Erk-mediated MMP expression.BMB Rep2015 JunSong KH-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr11433120985'UTRnovel0.5
BLCAchr1143330020Missense_MutationnovelL395F0.13
BLCAchr1143312133Silentrs775001209P2P0.53
BLCAchr1143335309Missense_MutationNAS437N0.35
BLCAchr1143328817Missense_MutationnovelH351Y0.22
BLCAchr1143323462SilentnovelV192V0.11
BLCAchr1143323463Missense_MutationnovelL193V0.09
BLCAchr11433120545'UTRnovel0.31
BRCAchr1143335916Nonsense_MutationNAG472*0.33
BRCAchr1143320824Nonsense_MutationNAR79*0.41
BRCAchr1143330561Missense_MutationnovelI425M0.37
BRCAchr1143318793Missense_MutationNAD75H0.51
BRCAchr1143320842Nonsense_MutationNAE85*0.23
BRCAchr1143323592Missense_MutationnovelD236H0.13
CESCchr1143328868Missense_MutationNAE368K0.19
CESCchr11433441053'Flanknovel0.05
CESCchr1143323454Nonsense_MutationNAE190*0.32
CESCchr11433432313'Flanknovel0.8
CESCchr11433437373'Flanknovel0.25
CESCchr11433443433'Flanknovel0.32
CHOLchr11433430633'Flanknovel0.16
COADchr1143342471Missense_MutationNAW512C0.29
COADchr1143330046Frame_Shift_DelNAT405Qfs*110.27
COADchr11433428133'Flanknovel0.57
COADchr1143323457Missense_MutationNAF191V0.33
COADchr1143323598Missense_MutationNAL238F0.34
COADchr1143329994Missense_MutationNAV386A0.22
COADchr1143336075Intronnovel0.48
COADchr1143321452Missense_MutationNAS123R0.26
COADchr1143330011Missense_MutationNAR392C0.32
COADchr1143318689Missense_MutationNAK40R0.13
ESCAchr11433425513'UTRnovel0.41
ESCAchr11433425183'UTRnovel0.3
GBMchr11433120965'UTRnovel0.89
HNSCchr1143342470Frame_Shift_DelnovelG513Afs*140.21
HNSCchr1143312185Nonsense_MutationnovelQ20*0.2
HNSCchr1143323503Missense_MutationnovelT206K0.32
KIRCchr1143318653Missense_MutationNAY28C0.07
KIRCchr1143328858Missense_MutationnovelK364N0.24
KIRPchr1143328750SilentNAG328G0.32
KIRPchr1143320891Missense_MutationNAI101T0.46
LGGchr1143322055SilentNAF154F0.31
LIHCchr11433120995'UTRrs7482019460.07
LIHCchr1143328795Frame_Shift_InsnovelE344*0.24
LIHCchr1143318777SilentnovelD69D0.53
LUADchr1143326611Missense_MutationNAE285D0.24
LUADchr1143318683Missense_Mutationrs35999189G38D0.25
LUADchr1143328736Nonsense_MutationnovelE324*0.23
LUADchr1143342487Missense_Mutationrs775372246R518C0.15
LUADchr1143327809Missense_MutationnovelE292D0.21
LUADchr1143312133SilentNAP2P0.19
LUADchr11433121085'UTRnovel0.21
LUSCchr1143335928Missense_MutationNAD476H0.21
LUSCchr1143312197Splice_SitenovelX23_splice0.13
LUSCchr1143329982Missense_MutationnovelR382L0.43
LUSCchr1143318727Frame_Shift_DelnovelF53Lfs*160.06
LUSCchr1143322052Missense_MutationNAK153N0.06
LUSCchr11433120665'UTRnovel0.18
LUSCchr1143328876SilentNAL370L0.18
LUSCchr1143329964Splice_SitenovelX376_splice0.22
LUSCchr1143328761Missense_MutationnovelG332D0.27
LUSCchr1143335276Splice_SitenovelX427_splice0.21
LUSCchr1143323435SilentNAL183L0.56
OVchr1143327843Missense_MutationnovelE304K0.22
PAADchr1143321411Missense_MutationnovelD109A0.17
PAADchr1143323501SilentnovelQ205Q0.16
PAADchr1143323608Missense_MutationnovelC241Y0.07
PAADchr1143329981Missense_MutationnovelR382W0.2
PAADchr1143336028Intronnovel0.21
PRADchr1143323555SilentNAL223L0.17
PRADchr1143335868Missense_MutationnovelA456S0.51
READchr1143320870Missense_MutationnovelN94I0.2
READchr1143323613Missense_MutationnovelR243W0.07
SARCchr1143320856SilentnovelF89F0.27
SARCchr1143320825Missense_Mutationrs770680039R79Q0.85
SKCMchr1143326566Silentrs756261606L270L0.26
SKCMchr1143342487Missense_Mutationrs775372246R518C0.15
SKCMchr1143326516Missense_MutationnovelH254Y0.28
SKCMchr1143323571Missense_MutationNAP229S0.33
SKCMchr1143323482Missense_MutationnovelS199F0.32
SKCMchr1143321430SilentNAN115N0.3
STADchr11433120255'UTRnovel0.38
STADchr1143320916Splice_SitenovelX109_splice0.06
STADchr1143342493Missense_MutationNAR520W0.2
STADchr1143329982Missense_MutationNAR382Q0.22
STADchr1143323576SilentNAS230S0.14
STADchr1143327805Missense_Mutationrs543630471A291V0.28
STADchr1143335277Splice_SiteNAX427_splice0.42
STADchr11433120455'UTRnovel0.56
STADchr1143330523Missense_MutationNAV413I0.08
STADchr1143328885Frame_Shift_InsnovelI375Nfs*240.23
THCAchr11433425253'UTRnovel0.06
THCAchr11433425263'UTRnovel0.05
UCECchr1143320824Nonsense_MutationNAR79*0.34
UCECchr11433432003'Flanknovel0.31
UCECchr1143318698Missense_MutationnovelR43Q0.4
UCECchr11433428013'Flanknovel0.3
UCECchr11433442343'Flanknovel0.29
UCECchr11433431963'Flanknovel0.44
UCECchr1143322098Missense_MutationNAK169E0.4
UCECchr1143323454Nonsense_MutationNAE190*0.49
UCECchr1143328830Missense_Mutationrs372123869R355Q0.4
UCECchr1143335317Missense_MutationnovelT440A0.35
UCECchr11433439343'Flanknovel0.67
UCECchr1143330037SilentnovelG400G0.31
UCECchr11433439283'Flanknovel0.39
UCECchr11433442483'Flanknovel0.14
UCECchr11433426453'UTRNA0.21
UCECchr11433431963'Flanknovel0.38
UCECchr1143322091SilentNAV166V0.26
UCECchr1143335952Missense_MutationNAP484S0.09
UCECchr11433431963'Flanknovel0.45
UCECchr1143330537Missense_MutationnovelI417M0.27
UCECchr1143318646Missense_MutationnovelD26Y0.08
UCECchr1143326555Missense_MutationnovelL267I0.09
UCECchr11433430993'Flanknovel0.29
UCECchr1143328830Missense_Mutationrs372123869R355Q0.45
UCECchr11433431963'Flanknovel0.25
UCECchr11433119875'Flanknovel0.33
UCECchr1143326559Missense_MutationnovelP268L0.21
UCECchr1143342443Missense_MutationnovelF503S0.27
UCECchr1143335909SilentNAS469S0.34
UCECchr11433431963'Flanknovel0.36
UCECchr11433444473'Flanknovel0.4
UCECchr11433120665'UTRnovel0.57
UCECchr1143330011Missense_MutationNAR392C0.58
UCECchr11433429033'Flanknovel0.44
UCECchr1143328842Missense_MutationnovelD359G0.29
UCECchr11433427313'Flanknovel0.15
UCECchr11433440023'Flanknovel0.15
UCECchr11433425623'UTRnovel0.39
UCECchr11433435853'Flanknovel0.1
UCECchr1143318720SilentnovelP50P0.23
UCECchr11433428293'Flanknovel0.28
UCECchr11433436813'Flanknovel0.4
UCECchr1143328773Missense_MutationnovelP336L0.29
UCECchr11433443713'Flanknovel0.16
UCECchr1143312150Missense_MutationnovelY8C0.15
UCECchr11433427173'FlankNA0.53
UCECchr11433120215'UTRnovel0.16
UCECchr11433429143'Flanknovel0.25
UCECchr1143326549Nonsense_MutationNAQ265*0.16
UCECchr1143321420Missense_MutationnovelA112V0.41
UCECchr11433431963'Flanknovel0.83
UCECchr11433120845'UTRrs7570102450.13
UCECchr1143318697Nonsense_Mutationrs780783169R43*0.38
UCECchr1143323567Missense_MutationNAF227L0.24
UCECchr1143330011Missense_MutationNAR392C0.3
UCECchr1143318697Nonsense_Mutationrs780783169R43*0.19
UCECchr1143320820Splice_SitenovelX78_splice0.42
UCECchr1143336006Intronrs3704638230.35
UCECchr1143335960SilentnovelG486G0.35
UCECchr11433440793'Flanknovel0.21
UCECchr11433431943'Flanknovel0.58
UCECchr11433444383'Flanknovel0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.17390.018342
GBMDEL0.13860.014054
PRADDEL0.05490.0050014
TGCTDEL0.60.21504

Survival Analysis
CancerP-value Q-value
THYM0.031

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.027

Kaplan-Meier Survival Analysis

ACC0.028

Kaplan-Meier Survival Analysis

UCS0.05

Kaplan-Meier Survival Analysis

COAD0.042

Kaplan-Meier Survival Analysis

BLCA0.048

Kaplan-Meier Survival Analysis

READ0.00046

Kaplan-Meier Survival Analysis

LIHC0.032

Kaplan-Meier Survival Analysis

LGG0.025

Kaplan-Meier Survival Analysis

OV0.017

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000166181 (Gene tree)
Gene ID
8539
Gene Symbol
API5
Alias
AAC-11|API5L1|AAC11
Full Name
apoptosis inhibitor 5
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
32,576 bases
Position
chr11:43,311,955-43,344,530
Accession
594
RBP type
non-canonical RBP
Summary
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000455725API5-2032257XM_017018464ENSP00000399341513 (aa)XP_016873953Q9BZZ5
ENST00000530300API5-207553--- (aa)--
ENST00000534600API5-2101760XM_006718359ENSP00000434462510 (aa)XP_006718422G3V1C3
ENST00000532267API5-209337--- (aa)--
ENST00000529334API5-205346--- (aa)--
ENST00000529932API5-206773--- (aa)--
ENST00000531273API5-2081868-ENSP00000431391524 (aa)-Q9BZZ5
ENST00000420461API5-2022009-ENSP00000402540450 (aa)-Q9BZZ5
ENST00000378852API5-2013714-ENSP00000368129504 (aa)-Q9BZZ5
ENST00000526394API5-204883-ENSP00000436436294 (aa)-H0YER7
ENST00000534695API5-211560-ENSP00000436189123 (aa)-E9PQK6
Gene Model
Click here to download ENSG00000166181's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166181's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000166181API59982.704ENSDARG00000033597api59682.157Danio_rerio
ENSG00000166181API59946.243FBgn0027885Aac119746.080Drosophila_melanogaster
ENSG00000166181API510098.413ENSMUSG00000027193Api510098.413Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding19387494.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus11075807.IDAComponent
GO:0005681spliceosomal complex11555636.ISSComponent
GO:0005737cytoplasm11075807.NASComponent
GO:0006915apoptotic process-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016607nuclear speck-IDAComponent
GO:0017134fibroblast growth factor binding11075807.IPIFunction
GO:0043066negative regulation of apoptotic process21873635.IBAProcess
GO:0043066negative regulation of apoptotic process11075807.IMPProcess
GO:0043066negative regulation of apoptotic process9307294.ISSProcess
GO:0043066negative regulation of apoptotic process10780674.NASProcess
GO:2000270negative regulation of fibroblast apoptotic process-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us