EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23782473Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma.World J Surg Oncol2013 Jun 19Zou Qdoi: 10.1186/1477-7819-11-143.
25704758Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.Exp Cell Res2015 Mar 15Guest STdoi: 10.1016/j.yexcr.2015.02.005

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr12696014333'UTRnovel0.35
ACCchr12695854505'UTRnovel0.09
BLCAchr1269597232Missense_MutationNAM353I0.44
BLCAchr1269593072Missense_MutationnovelL283I0.07
BLCAchr1269587532Missense_MutationNAD58N0.4
BLCAchr1269599997Missense_MutationnovelA524S0.11
BLCAchr1269593082Missense_MutationnovelG286E0.21
BRCAchr1269586805Missense_MutationnovelG44E0.07
BRCAchr1269587556Missense_MutationNAD66H0.2
BRCAchr12695854725'UTRrs5626300910.28
BRCAchr1269593532Missense_MutationNAE301K0.19
BRCAchr1269597230Missense_MutationNAM353V0.43
BRCAchr1269597676Nonsense_MutationNAQ381*0.43
BRCAchr1269597984Missense_MutationNAL416F0.46
CESCchr1269586284SilentnovelL6L0.23
CESCchr1269593529Missense_MutationNAP300S0.17
COADchr1269597271SilentNAA366A0.36
COADchr12695854955'UTRnovel0.3
COADchr1269588236Silentrs767503874A140A0.46
COADchr1269597678Missense_MutationNAQ381H0.2
COADchr1269589600Missense_MutationnovelL188F0.19
COADchr12696014903'UTRrs1879329200.4
COADchr1269588236Silentrs767503874A140A0.22
ESCAchr1269593002SilentnovelD259D0.3
ESCAchr1269586773Silentrs780733349I33I0.33
GBMchr1269593529Missense_MutationNAP300S0.04
GBMchr1269592114SilentNAA235A0.37
GBMchr1269597969Splice_RegionnovelG411G0.31
GBMchr1269586307Missense_MutationnovelA14E0.12
GBMchr1269598373Missense_MutationnovelA463T0.22
HNSCchr1269593021Missense_MutationnovelE266Q0.29
HNSCchr1269599990SilentnovelI521I0.3
HNSCchr1269593572Missense_MutationnovelH314L0.18
KIRCchr1269592066SilentNAL219L0.2
LGGchr1269597244SilentnovelD357D0.38
LIHCchr1269593020SilentNAA265A0.32
LIHCchr1269598353Missense_MutationnovelY456C0.3
LUADchr1269597673Missense_MutationNAQ380E0.19
LUADchr1269593607Missense_MutationNAV326I0.2
LUADchr1269589544Nonsense_MutationnovelS169*0.21
LUADchr1269588226Missense_MutationnovelA137V0.31
LUADchr1269599942SilentNAL505L0.06
LUADchr1269597638Missense_MutationNAG368V0.17
LUSCchr1269598049Missense_MutationnovelS438C0.18
LUSCchr1269589525Missense_MutationnovelA163T0.55
LUSCchr1269592993SilentnovelV256V0.48
LUSCchr1269588254SilentnovelV146V0.47
MESOchr1269593039Missense_MutationnovelK272E0.17
OVchr1269586306Missense_Mutationrs756203347A14T0.07
OVchr1269586313Frame_Shift_DelnovelA16Vfs*110.04
OVchr1269599983Missense_MutationnovelN519S0.17
OVchr12696013653'UTRnovel0.19
OVchr1269586273Missense_MutationnovelS3P0.07
OVchr1269592156SilentnovelI249I0.08
OVchr1269586816Missense_MutationnovelM48V0.13
OVchr1269597203Missense_MutationnovelG344R0.14
PAADchr1269593537SilentnovelQ302Q0.05
PAADchr1269597169SilentnovelA332A0.03
PAADchr1269597260Missense_MutationnovelS363A0.18
PRADchr1269593005Silentrs201962311S260S0.41
PRADchr1269592145Missense_MutationNAT246S0.35
PRADchr1269587514Missense_MutationnovelL52I0.12
PRADchr1269587603Frame_Shift_InsnovelV83Sfs*40.26
READchr1269597979Missense_MutationnovelM415L0.39
READchr1269588218Silentrs762745968T134T0.36
READchr1269593519Missense_MutationnovelI296M0.21
READchr1269597216Missense_MutationnovelL348R0.18
SARCchr12696013993'UTRnovel0.04
SARCchr1269588259Missense_MutationnovelH148L0.03
SARCchr1269593072Missense_MutationnovelL283V0.89
SKCMchr1269586274Missense_MutationNAS3F0.28
SKCMchr1269589503SilentNAF155F0.32
SKCMchr1269589503SilentNAF155F0.13
SKCMchr1269601299Missense_MutationNAR528G0.41
STADchr1269586787Missense_MutationNAL38S0.09
STADchr12696013353'UTRrs3722458520.45
STADchr1269598334Missense_Mutationrs746543261I450V0.18
STADchr1269588192Missense_MutationnovelI126V0.36
STADchr1269597227Missense_MutationnovelV352I0.34
STADchr1269597728Missense_Mutationrs201201152A398V0.51
STADchr1269588196Missense_MutationnovelI127T0.22
STADchr1269588199Missense_Mutationrs545752398A128V0.27
THCAchr1269592122Missense_MutationNAL238R0.39
UCECchr1269587982Silentrs773242699T103T0.3
UCECchr1269588236Silentrs767503874A140A0.25
UCECchr1269597213Missense_MutationnovelK347T0.1
UCECchr1269589567Missense_MutationNAD177Y0.34
UCECchr1269589525Missense_MutationnovelA163T0.11
UCECchr1269586773Silentrs780733349I33I0.28
UCECchr1269593067Missense_MutationNAR281H0.37
UCECchr12696015543'UTRnovel0.36
UCECchr1269586310Missense_MutationnovelG15V0.22
UCECchr1269597207Missense_MutationnovelS345I0.2
UCECchr1269586773Silentrs780733349I33I0.19
UCECchr1269586786SilentnovelL38L0.07
UCECchr1269597648SilentNAC371C0.05
UCECchr1269599901Missense_MutationnovelG492S0.44
UCECchr1269593531SilentnovelP300P0.34
UCECchr1269599928Nonsense_MutationnovelR501*0.29
UCECchr1269586774Missense_Mutationrs747763186A34T0.27
UCECchr1269598359Missense_Mutationrs146372909S458N0.48
UCECchr1269598354SilentNAY456Y0.43
UCECchr1269592100Nonsense_MutationNAR231*0.38
UCECchr1269587587Missense_MutationNAV76A0.23
UCECchr12696015603'UTRrs7566608610.4
UCECchr1269588178Missense_MutationnovelI121S0.44
UCECchr1269601303Missense_MutationnovelV529A0.14
UCECchr1269589490Missense_MutationnovelD151G0.23
UCECchr12696015593'UTRnovel0.46
UCECchr1269597204Missense_MutationNAG344E0.61
UCECchr1269592101Missense_MutationNAR231Q0.36
UCECchr12696014903'UTRrs1879329200.31
UCECchr1269589545Frame_Shift_DelnovelK170Nfs*130.25
UCECchr1269597701Nonsense_MutationnovelS389*0.1
UCECchr1269593033Missense_MutationnovelA270T0.09
UCECchr1269593558SilentnovelV309V0.41
UCECchr1269588218Silentrs762745968T134T0.48
UCECchr1269592993Silentrs780844993V256V0.54
UCECchr1269592101Missense_MutationNAR231Q0.33
UCECchr1269597688Nonsense_MutationNAE385*0.29
UCECchr1269598030Nonsense_MutationnovelE432*0.45
UCECchr1269592101Missense_MutationNAR231Q0.15
UCECchr1269592100Nonsense_MutationNAR231*0.28
UCECchr1269599995Missense_Mutationrs752254462A523V0.26
UCECchr1269592073Frame_Shift_DelNAI224Lfs*30.44
UCECchr1269588212SilentnovelE132E0.06
UCECchr1269599892Missense_MutationnovelA489T0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.02220.20414
BLCAAMP0.251.5107e-24
BRCAAMP0.20568.5616e-16
DLBCAMP0.20830.085003
ESCAAMP0.2121.8454e-06
HNSCAMP0.13221.2936e-10
LUSCAMP0.24950.00092392
OVAMP0.31780.16007
PAADAMP0.11410.0061805
READDEL0.09090.064633
TGCTAMP0.54670.00041421
UCSAMP0.26790.052337

Survival Analysis
CancerP-value Q-value
THYM0.046

Kaplan-Meier Survival Analysis

SARC0.00011

Kaplan-Meier Survival Analysis

MESO0.00013

Kaplan-Meier Survival Analysis

ACC0.00093

Kaplan-Meier Survival Analysis

HNSC0.0038

Kaplan-Meier Survival Analysis

PRAD0.034

Kaplan-Meier Survival Analysis

BRCA0.0082

Kaplan-Meier Survival Analysis

ESCA0.024

Kaplan-Meier Survival Analysis

COAD0.011

Kaplan-Meier Survival Analysis

PCPG0.035

Kaplan-Meier Survival Analysis

KICH0.0026

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LUAD0.00064

Kaplan-Meier Survival Analysis

OV0.0073

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000166226 (Gene tree)
Gene ID
10576
Gene Symbol
CCT2
Alias
Cctb
Full Name
chaperonin containing TCP1 subunit 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
16,244 bases
Position
chr12:69,585,334-69,601,577
Accession
1615
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000549933CCT2-207536--- (aa)--
ENST00000551620CCT2-212776--- (aa)--
ENST00000550455CCT2-209481--- (aa)--
ENST00000553169CCT2-214758--- (aa)--
ENST00000550638CCT2-210683--- (aa)--
ENST00000548787CCT2-206852--- (aa)--
ENST00000550653CCT2-211567--- (aa)--
ENST00000546859CCT2-205595--- (aa)--
ENST00000544368CCT2-2031728-ENSP00000441847530 (aa)-F5GWF6
ENST00000550010CCT2-2081754-ENSP00000450153416 (aa)-F8VQ14
ENST00000551899CCT2-213572--- (aa)--
ENST00000299300CCT2-2012041-ENSP00000299300535 (aa)-P78371
ENST00000546850CCT2-204364--- (aa)--
ENST00000543146CCT2-2022189-ENSP00000445471488 (aa)-P78371
Gene Model
Click here to download ENSG00000166226's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000166226Creatinine4.55226816924852E-617903292
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000166226rs26010061269585737CUrinary albumin excretion30220432[0.0083-0.0152] unit increase0.01176EFO_0004285
ENSG00000166226rs26010061269585737CUrinary albumin excretion (no hypertensive medication)30220432[0.0073-0.0145] unit increase0.01086EFO_0004285
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166226's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000166226CCT29870.073WBGene00000378cct-210066.353Caenorhabditis_elegans
ENSG00000166226CCT210097.570ENSMUSG00000034024Cct210098.438Mus_musculus
ENSG00000166226CCT29769.231YIL142WCCT29965.905Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002199zona pellucida receptor complex-IEAComponent
GO:0005515protein binding14532270.16085932.16097032.20080638.22500027.25416956.25467444.27353360.30021884.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005576extracellular region-TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol11532003.NASComponent
GO:0005829cytosol-TASComponent
GO:0005832chaperonin-containing T-complex21873635.IBAComponent
GO:0005832chaperonin-containing T-complex23011926.25467444.IDAComponent
GO:0005874microtubule21525035.IDAComponent
GO:0006457protein folding11532003.NASProcess
GO:0006457protein folding-TASProcess
GO:0007339binding of sperm to zona pellucida-IEAProcess
GO:0031625ubiquitin protein ligase binding21753002.IPIFunction
GO:0032212positive regulation of telomere maintenance via telomerase25467444.IMPProcess
GO:0035578azurophil granule lumen-TASComponent
GO:0043312neutrophil degranulation-TASProcess
GO:0044183protein binding involved in protein folding25467444.IDAFunction
GO:0044297cell body-IEAComponent
GO:0050821protein stabilization25467444.IMPProcess
GO:0051082unfolded protein binding11532003.NASFunction
GO:0051086chaperone mediated protein folding independent of cofactor25467444.IMPProcess
GO:0051131chaperone-mediated protein complex assembly20080638.IMPProcess
GO:0051973positive regulation of telomerase activity25467444.IMPProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0090666scaRNA localization to Cajal body25467444.IMPProcess
GO:1901998toxin transport-IEAProcess
GO:1904851positive regulation of establishment of protein localization to telomere25467444.IMPProcess
GO:1904871positive regulation of protein localization to Cajal body25467444.HMPProcess
GO:1904874positive regulation of telomerase RNA localization to Cajal body25467444.HMPProcess
GO:1904874positive regulation of telomerase RNA localization to Cajal body25467444.IMPProcess
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