EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23782473	Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma.	World J Surg Oncol	2013 Jun 19	Zou Q	doi: 10.1186/1477-7819-11-143.
25704758	Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.	Exp Cell Res	2015 Mar 15	Guest ST	doi: 10.1016/j.yexcr.2015.02.005

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	69601433	3'UTR	novel		0.35
ACC	chr12	69585450	5'UTR	novel		0.09
BLCA	chr12	69597232	Missense_Mutation	NA	M353I	0.44
BLCA	chr12	69593072	Missense_Mutation	novel	L283I	0.07
BLCA	chr12	69587532	Missense_Mutation	NA	D58N	0.4
BLCA	chr12	69599997	Missense_Mutation	novel	A524S	0.11
BLCA	chr12	69593082	Missense_Mutation	novel	G286E	0.21
BRCA	chr12	69586805	Missense_Mutation	novel	G44E	0.07
BRCA	chr12	69587556	Missense_Mutation	NA	D66H	0.2
BRCA	chr12	69585472	5'UTR	rs562630091		0.28
BRCA	chr12	69593532	Missense_Mutation	NA	E301K	0.19
BRCA	chr12	69597230	Missense_Mutation	NA	M353V	0.43
BRCA	chr12	69597676	Nonsense_Mutation	NA	Q381*	0.43
BRCA	chr12	69597984	Missense_Mutation	NA	L416F	0.46
CESC	chr12	69586284	Silent	novel	L6L	0.23
CESC	chr12	69593529	Missense_Mutation	NA	P300S	0.17
COAD	chr12	69597271	Silent	NA	A366A	0.36
COAD	chr12	69585495	5'UTR	novel		0.3
COAD	chr12	69588236	Silent	rs767503874	A140A	0.46
COAD	chr12	69597678	Missense_Mutation	NA	Q381H	0.2
COAD	chr12	69589600	Missense_Mutation	novel	L188F	0.19
COAD	chr12	69601490	3'UTR	rs187932920		0.4
COAD	chr12	69588236	Silent	rs767503874	A140A	0.22
ESCA	chr12	69593002	Silent	novel	D259D	0.3
ESCA	chr12	69586773	Silent	rs780733349	I33I	0.33
GBM	chr12	69593529	Missense_Mutation	NA	P300S	0.04
GBM	chr12	69592114	Silent	NA	A235A	0.37
GBM	chr12	69597969	Splice_Region	novel	G411G	0.31
GBM	chr12	69586307	Missense_Mutation	novel	A14E	0.12
GBM	chr12	69598373	Missense_Mutation	novel	A463T	0.22
HNSC	chr12	69593021	Missense_Mutation	novel	E266Q	0.29
HNSC	chr12	69599990	Silent	novel	I521I	0.3
HNSC	chr12	69593572	Missense_Mutation	novel	H314L	0.18
KIRC	chr12	69592066	Silent	NA	L219L	0.2
LGG	chr12	69597244	Silent	novel	D357D	0.38
LIHC	chr12	69593020	Silent	NA	A265A	0.32
LIHC	chr12	69598353	Missense_Mutation	novel	Y456C	0.3
LUAD	chr12	69597673	Missense_Mutation	NA	Q380E	0.19
LUAD	chr12	69593607	Missense_Mutation	NA	V326I	0.2
LUAD	chr12	69589544	Nonsense_Mutation	novel	S169*	0.21
LUAD	chr12	69588226	Missense_Mutation	novel	A137V	0.31
LUAD	chr12	69599942	Silent	NA	L505L	0.06
LUAD	chr12	69597638	Missense_Mutation	NA	G368V	0.17
LUSC	chr12	69598049	Missense_Mutation	novel	S438C	0.18
LUSC	chr12	69589525	Missense_Mutation	novel	A163T	0.55
LUSC	chr12	69592993	Silent	novel	V256V	0.48
LUSC	chr12	69588254	Silent	novel	V146V	0.47
MESO	chr12	69593039	Missense_Mutation	novel	K272E	0.17
OV	chr12	69586306	Missense_Mutation	rs756203347	A14T	0.07
OV	chr12	69586313	Frame_Shift_Del	novel	*A16Vfs11**	0.04
OV	chr12	69599983	Missense_Mutation	novel	N519S	0.17
OV	chr12	69601365	3'UTR	novel		0.19
OV	chr12	69586273	Missense_Mutation	novel	S3P	0.07
OV	chr12	69592156	Silent	novel	I249I	0.08
OV	chr12	69586816	Missense_Mutation	novel	M48V	0.13
OV	chr12	69597203	Missense_Mutation	novel	G344R	0.14
PAAD	chr12	69593537	Silent	novel	Q302Q	0.05
PAAD	chr12	69597169	Silent	novel	A332A	0.03
PAAD	chr12	69597260	Missense_Mutation	novel	S363A	0.18
PRAD	chr12	69593005	Silent	rs201962311	S260S	0.41
PRAD	chr12	69592145	Missense_Mutation	NA	T246S	0.35
PRAD	chr12	69587514	Missense_Mutation	novel	L52I	0.12
PRAD	chr12	69587603	Frame_Shift_Ins	novel	*V83Sfs4**	0.26
READ	chr12	69597979	Missense_Mutation	novel	M415L	0.39
READ	chr12	69588218	Silent	rs762745968	T134T	0.36
READ	chr12	69593519	Missense_Mutation	novel	I296M	0.21
READ	chr12	69597216	Missense_Mutation	novel	L348R	0.18
SARC	chr12	69601399	3'UTR	novel		0.04
SARC	chr12	69588259	Missense_Mutation	novel	H148L	0.03
SARC	chr12	69593072	Missense_Mutation	novel	L283V	0.89
SKCM	chr12	69586274	Missense_Mutation	NA	S3F	0.28
SKCM	chr12	69589503	Silent	NA	F155F	0.32
SKCM	chr12	69589503	Silent	NA	F155F	0.13
SKCM	chr12	69601299	Missense_Mutation	NA	R528G	0.41
STAD	chr12	69586787	Missense_Mutation	NA	L38S	0.09
STAD	chr12	69601335	3'UTR	rs372245852		0.45
STAD	chr12	69598334	Missense_Mutation	rs746543261	I450V	0.18
STAD	chr12	69588192	Missense_Mutation	novel	I126V	0.36
STAD	chr12	69597227	Missense_Mutation	novel	V352I	0.34
STAD	chr12	69597728	Missense_Mutation	rs201201152	A398V	0.51
STAD	chr12	69588196	Missense_Mutation	novel	I127T	0.22
STAD	chr12	69588199	Missense_Mutation	rs545752398	A128V	0.27
THCA	chr12	69592122	Missense_Mutation	NA	L238R	0.39
UCEC	chr12	69587982	Silent	rs773242699	T103T	0.3
UCEC	chr12	69588236	Silent	rs767503874	A140A	0.25
UCEC	chr12	69597213	Missense_Mutation	novel	K347T	0.1
UCEC	chr12	69589567	Missense_Mutation	NA	D177Y	0.34
UCEC	chr12	69589525	Missense_Mutation	novel	A163T	0.11
UCEC	chr12	69586773	Silent	rs780733349	I33I	0.28
UCEC	chr12	69593067	Missense_Mutation	NA	R281H	0.37
UCEC	chr12	69601554	3'UTR	novel		0.36
UCEC	chr12	69586310	Missense_Mutation	novel	G15V	0.22
UCEC	chr12	69597207	Missense_Mutation	novel	S345I	0.2
UCEC	chr12	69586773	Silent	rs780733349	I33I	0.19
UCEC	chr12	69586786	Silent	novel	L38L	0.07
UCEC	chr12	69597648	Silent	NA	C371C	0.05
UCEC	chr12	69599901	Missense_Mutation	novel	G492S	0.44
UCEC	chr12	69593531	Silent	novel	P300P	0.34
UCEC	chr12	69599928	Nonsense_Mutation	novel	R501*	0.29
UCEC	chr12	69586774	Missense_Mutation	rs747763186	A34T	0.27
UCEC	chr12	69598359	Missense_Mutation	rs146372909	S458N	0.48
UCEC	chr12	69598354	Silent	NA	Y456Y	0.43
UCEC	chr12	69592100	Nonsense_Mutation	NA	R231*	0.38
UCEC	chr12	69587587	Missense_Mutation	NA	V76A	0.23
UCEC	chr12	69601560	3'UTR	rs756660861		0.4
UCEC	chr12	69588178	Missense_Mutation	novel	I121S	0.44
UCEC	chr12	69601303	Missense_Mutation	novel	V529A	0.14
UCEC	chr12	69589490	Missense_Mutation	novel	D151G	0.23
UCEC	chr12	69601559	3'UTR	novel		0.46
UCEC	chr12	69597204	Missense_Mutation	NA	G344E	0.61
UCEC	chr12	69592101	Missense_Mutation	NA	R231Q	0.36
UCEC	chr12	69601490	3'UTR	rs187932920		0.31
UCEC	chr12	69589545	Frame_Shift_Del	novel	*K170Nfs13**	0.25
UCEC	chr12	69597701	Nonsense_Mutation	novel	S389*	0.1
UCEC	chr12	69593033	Missense_Mutation	novel	A270T	0.09
UCEC	chr12	69593558	Silent	novel	V309V	0.41
UCEC	chr12	69588218	Silent	rs762745968	T134T	0.48
UCEC	chr12	69592993	Silent	rs780844993	V256V	0.54
UCEC	chr12	69592101	Missense_Mutation	NA	R231Q	0.33
UCEC	chr12	69597688	Nonsense_Mutation	NA	E385*	0.29
UCEC	chr12	69598030	Nonsense_Mutation	novel	E432*	0.45
UCEC	chr12	69592101	Missense_Mutation	NA	R231Q	0.15
UCEC	chr12	69592100	Nonsense_Mutation	NA	R231*	0.28
UCEC	chr12	69599995	Missense_Mutation	rs752254462	A523V	0.26
UCEC	chr12	69592073	Frame_Shift_Del	NA	*I224Lfs3**	0.44
UCEC	chr12	69588212	Silent	novel	E132E	0.06
UCEC	chr12	69599892	Missense_Mutation	novel	A489T	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
BLCA	AMP	0.25	1.5107e-24
BRCA	AMP	0.2056	8.5616e-16
DLBC	AMP	0.2083	0.085003
ESCA	AMP	0.212	1.8454e-06
HNSC	AMP	0.1322	1.2936e-10
LUSC	AMP	0.2495	0.00092392
OV	AMP	0.3178	0.16007
PAAD	AMP	0.1141	0.0061805
READ	DEL	0.0909	0.064633
TGCT	AMP	0.5467	0.00041421
UCS	AMP	0.2679	0.052337

Survival Analysis

Cancer	P-value	Q-value
THYM	0.046	Kaplan-Meier Survival Analysis
SARC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.00013	Kaplan-Meier Survival Analysis
ACC	0.00093	Kaplan-Meier Survival Analysis
HNSC	0.0038	Kaplan-Meier Survival Analysis
PRAD	0.034	Kaplan-Meier Survival Analysis
BRCA	0.0082	Kaplan-Meier Survival Analysis
ESCA	0.024	Kaplan-Meier Survival Analysis
COAD	0.011	Kaplan-Meier Survival Analysis
PCPG	0.035	Kaplan-Meier Survival Analysis
KICH	0.0026	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00064	Kaplan-Meier Survival Analysis
OV	0.0073	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166226 (Gene tree)
Gene ID: 10576
Gene Symbol: CCT2
Alias: Cctb
Full Name: chaperonin containing TCP1 subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 16,244 bases
Position: chr12:69,585,334-69,601,577
Accession: 1615
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549933	CCT2-207	536	-	-	- (aa)	-	-
ENST00000551620	CCT2-212	776	-	-	- (aa)	-	-
ENST00000550455	CCT2-209	481	-	-	- (aa)	-	-
ENST00000553169	CCT2-214	758	-	-	- (aa)	-	-
ENST00000550638	CCT2-210	683	-	-	- (aa)	-	-
ENST00000548787	CCT2-206	852	-	-	- (aa)	-	-
ENST00000550653	CCT2-211	567	-	-	- (aa)	-	-
ENST00000546859	CCT2-205	595	-	-	- (aa)	-	-
ENST00000544368	CCT2-203	1728	-	ENSP00000441847	530 (aa)	-	F5GWF6
ENST00000550010	CCT2-208	1754	-	ENSP00000450153	416 (aa)	-	F8VQ14
ENST00000551899	CCT2-213	572	-	-	- (aa)	-	-
ENST00000299300	CCT2-201	2041	-	ENSP00000299300	535 (aa)	-	P78371
ENST00000546850	CCT2-204	364	-	-	- (aa)	-	-
ENST00000543146	CCT2-202	2189	-	ENSP00000445471	488 (aa)	-	P78371

Gene Model

Click here to download ENSG00000166226's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000166226	Creatinine	4.55226816924852E-6	17903292

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000166226	rs2601006	12	69585737	C	Urinary albumin excretion	30220432	[0.0083-0.0152] unit increase	0.01176	EFO_0004285
ENSG00000166226	rs2601006	12	69585737	C	Urinary albumin excretion (no hypertensive medication)	30220432	[0.0073-0.0145] unit increase	0.01086	EFO_0004285

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166226's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166226	CCT2	98	70.073	WBGene00000378	cct-2	100	66.353	Caenorhabditis_elegans
ENSG00000166226	CCT2	100	97.570	ENSMUSG00000034024	Cct2	100	98.438	Mus_musculus
ENSG00000166226	CCT2	97	69.231	YIL142W	CCT2	99	65.905	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002199	zona pellucida receptor complex	-	IEA	Component
GO:0005515	protein binding	14532270.16085932.16097032.20080638.22500027.25416956.25467444.27353360.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	11532003.	NAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005832	chaperonin-containing T-complex	21873635.	IBA	Component
GO:0005832	chaperonin-containing T-complex	23011926.25467444.	IDA	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006457	protein folding	11532003.	NAS	Process
GO:0006457	protein folding	-	TAS	Process
GO:0007339	binding of sperm to zona pellucida	-	IEA	Process
GO:0031625	ubiquitin protein ligase binding	21753002.	IPI	Function
GO:0032212	positive regulation of telomere maintenance via telomerase	25467444.	IMP	Process
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044183	protein binding involved in protein folding	25467444.	IDA	Function
GO:0044297	cell body	-	IEA	Component
GO:0050821	protein stabilization	25467444.	IMP	Process
GO:0051082	unfolded protein binding	11532003.	NAS	Function
GO:0051086	chaperone mediated protein folding independent of cofactor	25467444.	IMP	Process
GO:0051131	chaperone-mediated protein complex assembly	20080638.	IMP	Process
GO:0051973	positive regulation of telomerase activity	25467444.	IMP	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0090666	scaRNA localization to Cajal body	25467444.	IMP	Process
GO:1901998	toxin transport	-	IEA	Process
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.