EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17046751Endonuclease G promotes cell death of non-invasive human breast cancer cells.Exp Cell Res2006 Dec 10Basnakian AG-
23764847CHIP has a protective role against oxidative stress-induced cell death through specific regulation of endonuclease G.Cell Death Dis2013 Jun 13Lee JSdoi: 10.1038/cddis.2013.181.
21080888Mutational analysis of pro-apoptotic ENDOG gene in common solid cancers and acute leukaemias.Pathology2010 DecKim MSdoi: 10.3109/00313025.2010.523692.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
CESCchr9128822596Missense_MutationNAA294T0.31
COADchr9128822470Missense_MutationnovelA252T0.2Endonuclease_NS
COADchr9128820741Splice_RegionnovelV168V0.29
COADchr9128822573Missense_MutationNAA286V0.43
COADchr9128822589SilentNAA291A0.38
COADchr9128820826Missense_MutationnovelT197A0.17Endonuclease_NS
COADchr9128820788Missense_Mutationrs145739062R184H0.26Endonuclease_NS
COADchr9128822570Missense_MutationNAR285L0.37
KIRCchr9128820848Missense_MutationnovelR204K0.23Endonuclease_NS
LIHCchr9128822582Missense_MutationNAL289R0.19
LUSCchr9128822369Missense_MutationnovelI218T0.24Endonuclease_NS
LUSCchr9128820816SilentnovelV193V0.4
PAADchr9128822367SilentnovelV217V0.11
STADchr9128822459Missense_MutationNAV248A0.28Endonuclease_NS
UCECchr9128822569Missense_Mutationrs767328963R285W0.59
UCECchr9128820849Splice_Siters760067135X204_splice0.3
UCECchr9128820758Missense_MutationnovelN174S0.2Endonuclease_NS
UCECchr9128822518Missense_Mutationrs776376143E268K0.23Endonuclease_NS

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.00520.24147
LGGAMP0.06040.21332
LIHCDEL0.25140.12467
PRADAMP0.07930.059049
THCADEL0.04010.24038
THYMDEL0.01630.022012
UCSDEL0.57140.089783

Survival Analysis
CancerP-value Q-value
THYM0.045

Kaplan-Meier Survival Analysis

STAD0.018

Kaplan-Meier Survival Analysis

ACC0.0067

Kaplan-Meier Survival Analysis

UCS0.015

Kaplan-Meier Survival Analysis

SKCM0.00051

Kaplan-Meier Survival Analysis

PRAD0.041

Kaplan-Meier Survival Analysis

KIRP0.0057

Kaplan-Meier Survival Analysis

PAAD0.0044

Kaplan-Meier Survival Analysis

LAML0.0024

Kaplan-Meier Survival Analysis

UCEC0.0017

Kaplan-Meier Survival Analysis

DLBC0.0049

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.037

Kaplan-Meier Survival Analysis

UVM0.011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000167136 (Gene tree)
Gene ID
2021
Gene Symbol
ENDOG
Alias
N
Full Name
endonuclease G
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
4,268 bases
Position
chr9:128,818,411-128,822,678
Accession
3346
RBP type
canonical RBP
Summary
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000361725Endonuclease_NSPF01223.238.3e-6211

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15066427Structural and functional characterization of mitochondrial EndoG, a sugar non-specific nuclease which plays an important role during apoptosis.J Mol Biol2004 Apr 23Schafer P-
11859412A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid.Cell Death Differ2002 MarVan Loo G-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000372642ENDOG-2011172XM_011518347ENSP00000361725297 (aa)XP_011516649Q14249
Gene Model
Click here to download ENSG00000167136's gene model file
Pathways
Pathway IDPathway NameSource
hsa04210ApoptosisKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167136's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000167136ENDOG8138.115ENSG00000157036EXOG8242.581
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000167136ENDOG9864.333ENSAPOG00000001316endog9865.646Acanthochromis_polyacanthus
ENSG00000167136ENDOG7790.351ENSAMEG00000015801ENDOG10090.351Ailuropoda_melanoleuca
ENSG00000167136ENDOG9863.758ENSACIG00000007086endog9963.051Amphilophus_citrinellus
ENSG00000167136ENDOG8072.269ENSAOCG00000013970endog9964.746Amphiprion_ocellaris
ENSG00000167136ENDOG8366.802ENSAPEG00000024202endog9961.279Amphiprion_percula
ENSG00000167136ENDOG9967.224ENSATEG00000015467endog9966.107Anabas_testudineus
ENSG00000167136ENDOG7080.288ENSAPLG00000004952ENDOG10080.288Anas_platyrhynchos
ENSG00000167136ENDOG9765.449ENSACLG00000009792endog9864.430Astatotilapia_calliptera
ENSG00000167136ENDOG8770.260ENSAMXG00000032808endog9863.725Astyanax_mexicanus
ENSG00000167136ENDOG8089.167ENSBTAG00000012484ENDOG7989.167Bos_taurus
ENSG00000167136ENDOG7449.327WBGene00000787cps-67049.770Caenorhabditis_elegans
ENSG00000167136ENDOG10094.649ENSCJAG00000020220ENDOG10093.980Callithrix_jacchus
ENSG00000167136ENDOG9394.286ENSCAFG00000020036ENDOG10093.000Canis_familiaris
ENSG00000167136ENDOG9394.286ENSCAFG00020022974ENDOG10093.000Canis_lupus_dingo
ENSG00000167136ENDOG9392.832ENSCHIG00000020781ENDOG10091.304Capra_hircus
ENSG00000167136ENDOG10091.304ENSCPOG00000025286ENDOG10090.635Cavia_porcellus
ENSG00000167136ENDOG10087.625ENSCCAG00000028186ENDOG10086.622Cebus_capucinus
ENSG00000167136ENDOG10096.321ENSCATG00000037516ENDOG10096.321Cercocebus_atys
ENSG00000167136ENDOG8095.378ENSCLAG00000006402ENDOG9695.745Chinchilla_lanigera
ENSG00000167136ENDOG10096.990ENSCSAG00000014436ENDOG10096.990Chlorocebus_sabaeus
ENSG00000167136ENDOG8980.682ENSCPBG00000023353ENDOG9776.531Chrysemys_picta_bellii
ENSG00000167136ENDOG7752.586ENSCING00000014331-8453.333Ciona_intestinalis
ENSG00000167136ENDOG10087.919ENSCGRG00001024006Endog10086.532Cricetulus_griseus_chok1gshd
ENSG00000167136ENDOG6196.111ENSCGRG00000012823Endog8891.667Cricetulus_griseus_crigri
ENSG00000167136ENDOG8770.992ENSCSEG00000008066endog9865.424Cynoglossus_semilaevis
ENSG00000167136ENDOG9766.102ENSCVAG00000010105endog9865.424Cyprinodon_variegatus
ENSG00000167136ENDOG9767.000ENSDARG00000058865endog9865.667Danio_rerio
ENSG00000167136ENDOG9393.141ENSDNOG00000031222-9991.246Dasypus_novemcinctus
ENSG00000167136ENDOG6291.848ENSDNOG00000024568-8089.216Dasypus_novemcinctus
ENSG00000167136ENDOG8983.032ENSDORG00000028893Endog9196.429Dipodomys_ordii
ENSG00000167136ENDOG8530.147FBgn0037857Tengl45832.127Drosophila_melanogaster
ENSG00000167136ENDOG7346.154FBgn0052463Tengl26946.154Drosophila_melanogaster
ENSG00000167136ENDOG9549.495FBgn0033690EndoG9647.987Drosophila_melanogaster
ENSG00000167136ENDOG10092.308ENSEASG00005007720ENDOG10092.642Equus_asinus_asinus
ENSG00000167136ENDOG10093.311ENSECAG00000009809ENDOG10092.642Equus_caballus
ENSG00000167136ENDOG9865.132ENSELUG00000015964endog9663.455Esox_lucius
ENSG00000167136ENDOG8994.697ENSFCAG00000005859ENDOG10093.289Felis_catus
ENSG00000167136ENDOG8580.080ENSFALG00000001421ENDOG9482.128Ficedula_albicollis
ENSG00000167136ENDOG9168.478ENSFHEG00000007793endog9866.330Fundulus_heteroclitus
ENSG00000167136ENDOG5972.472ENSGMOG00000004330endog9473.214Gadus_morhua
ENSG00000167136ENDOG7774.672ENSGAFG00000002401endog9974.672Gambusia_affinis
ENSG00000167136ENDOG9965.789ENSGACG00000010633endog9971.304Gasterosteus_aculeatus
ENSG00000167136ENDOG7781.739ENSGAGG00000021110ENDOG9774.150Gopherus_agassizii
ENSG00000167136ENDOG10098.990ENSGGOG00000014224ENDOG10098.990Gorilla_gorilla
ENSG00000167136ENDOG9764.189ENSHBUG00000003699endog9863.423Haplochromis_burtoni
ENSG00000167136ENDOG9391.398ENSHGLG00000011977ENDOG10090.635Heterocephalus_glaber_female
ENSG00000167136ENDOG5884.000ENSHGLG00100018337ENDOG8884.000Heterocephalus_glaber_male
ENSG00000167136ENDOG9864.548ENSHCOG00000020736endog9963.514Hippocampus_comes
ENSG00000167136ENDOG9967.224ENSIPUG00000009770endog9766.221Ictalurus_punctatus
ENSG00000167136ENDOG9380.142ENSSTOG00000022690ENDOG10081.034Ictidomys_tridecemlineatus
ENSG00000167136ENDOG9067.518ENSKMAG00000005240endog9965.203Kryptolebias_marmoratus
ENSG00000167136ENDOG9967.785ENSLBEG00000015579endog9967.450Labrus_bergylta
ENSG00000167136ENDOG9967.869ENSLACG00000015490ENDOG9766.667Latimeria_chalumnae
ENSG00000167136ENDOG9865.333ENSLOCG00000004163endog9665.000Lepisosteus_oculatus
ENSG00000167136ENDOG5596.341ENSLAFG00000028267ENDOG7396.341Loxodonta_africana
ENSG00000167136ENDOG10095.987ENSMFAG00000044505ENDOG10095.987Macaca_fascicularis
ENSG00000167136ENDOG10096.321ENSMMUG00000003294ENDOG10096.321Macaca_mulatta
ENSG00000167136ENDOG10096.656ENSMNEG00000030787ENDOG10096.656Macaca_nemestrina
ENSG00000167136ENDOG9068.165ENSMAMG00000021431endog9865.333Mastacembelus_armatus
ENSG00000167136ENDOG9765.449ENSMZEG00005020825endog9864.430Maylandia_zebra
ENSG00000167136ENDOG7985.106ENSMGAG00000004558ENDOG9981.226Meleagris_gallopavo
ENSG00000167136ENDOG10087.919ENSMAUG00000015619Endog10086.195Mesocricetus_auratus
ENSG00000167136ENDOG8099.163ENSMICG00000017648ENDOG8299.149Microcebus_murinus
ENSG00000167136ENDOG10088.255ENSMOCG00000010842Endog10086.869Microtus_ochrogaster
ENSG00000167136ENDOG9864.407ENSMMOG00000021056endog9763.265Mola_mola
ENSG00000167136ENDOG7988.085ENSMODG00000006458ENDOG10080.068Monodelphis_domestica
ENSG00000167136ENDOG8765.769ENSMALG00000001723endog9962.457Monopterus_albus
ENSG00000167136ENDOG10089.262MGP_CAROLIEiJ_G0023383Endog10087.879Mus_caroli
ENSG00000167136ENDOG10089.262ENSMUSG00000015337Endog10087.879Mus_musculus
ENSG00000167136ENDOG10089.933MGP_PahariEiJ_G0024840Endog10088.552Mus_pahari
ENSG00000167136ENDOG10089.262MGP_SPRETEiJ_G0024300Endog10087.879Mus_spretus
ENSG00000167136ENDOG7996.186ENSMPUG00000013024ENDOG9996.186Mustela_putorius_furo
ENSG00000167136ENDOG9394.946ENSMLUG00000014319ENDOG10093.603Myotis_lucifugus
ENSG00000167136ENDOG10083.502ENSNGAG00000020601Endog10083.838Nannospalax_galili
ENSG00000167136ENDOG9565.763ENSNBRG00000023525endog9664.726Neolamprologus_brichardi
ENSG00000167136ENDOG6798.500ENSNLEG00000017615-7298.500Nomascus_leucogenys
ENSG00000167136ENDOG9185.240ENSMEUG00000006298ENDOG10081.481Notamacropus_eugenii
ENSG00000167136ENDOG10089.967ENSODEG00000017274ENDOG10088.963Octodon_degus
ENSG00000167136ENDOG8071.074ENSONIG00000000792endog9772.034Oreochromis_niloticus
ENSG00000167136ENDOG9867.667ENSORLG00000016300endog9966.890Oryzias_latipes
ENSG00000167136ENDOG9768.027ENSORLG00020019290endog9866.667Oryzias_latipes_hni
ENSG00000167136ENDOG9867.340ENSORLG00015008601endog9965.986Oryzias_latipes_hsok
ENSG00000167136ENDOG9866.327ENSOMEG00000003638endog9966.327Oryzias_melastigma
ENSG00000167136ENDOG10090.635ENSOGAG00000024803ENDOG10090.635Otolemur_garnettii
ENSG00000167136ENDOG10091.304ENSOARG00000009369ENDOG10091.304Ovis_aries
ENSG00000167136ENDOG6399.468ENSPPAG00000041190-10099.468Pan_paniscus
ENSG00000167136ENDOG8994.697ENSPPRG00000014165ENDOG10093.289Panthera_pardus
ENSG00000167136ENDOG10098.990ENSPTRG00000029057ENDOG10098.990Pan_troglodytes
ENSG00000167136ENDOG10096.321ENSPANG00000025933ENDOG10096.321Papio_anubis
ENSG00000167136ENDOG9865.333ENSPKIG00000020744endog9664.667Paramormyrops_kingsleyae
ENSG00000167136ENDOG5382.278ENSPSIG00000018149ENDOG9882.278Pelodiscus_sinensis
ENSG00000167136ENDOG9859.060ENSPMGG00000015292ENDOG9660.279Periophthalmus_magnuspinnatus
ENSG00000167136ENDOG10088.255ENSPEMG00000011395Endog10086.195Peromyscus_maniculatus_bairdii
ENSG00000167136ENDOG9081.648ENSPCIG00000030115ENDOG9980.068Phascolarctos_cinereus
ENSG00000167136ENDOG9865.552ENSPFOG00000011891endog9864.765Poecilia_formosa
ENSG00000167136ENDOG9865.217ENSPLAG00000007233endog9864.430Poecilia_latipinna
ENSG00000167136ENDOG9865.886ENSPMEG00000013321endog9865.101Poecilia_mexicana
ENSG00000167136ENDOG9865.886ENSPREG00000016271endog9864.983Poecilia_reticulata
ENSG00000167136ENDOG10097.306ENSPPYG00000019663ENDOG10097.306Pongo_abelii
ENSG00000167136ENDOG10089.298ENSPCAG00000012182ENDOG10088.963Procavia_capensis
ENSG00000167136ENDOG10095.333ENSPCOG00000022447ENDOG10095.333Propithecus_coquereli
ENSG00000167136ENDOG10087.086ENSPVAG00000003453ENDOG10087.086Pteropus_vampyrus
ENSG00000167136ENDOG8072.917ENSPNYG00000003381endog8273.932Pundamilia_nyererei
ENSG00000167136ENDOG9967.000ENSPNAG00000024256endog9767.000Pygocentrus_nattereri
ENSG00000167136ENDOG10088.591ENSRNOG00000016033Endog10086.869Rattus_norvegicus
ENSG00000167136ENDOG9390.975ENSRBIG00000026558ENDOG9492.075Rhinopithecus_bieti
ENSG00000167136ENDOG10083.838ENSRROG00000038553ENDOG10083.838Rhinopithecus_roxellana
ENSG00000167136ENDOG7342.920YJL208C-6743.439Saccharomyces_cerevisiae
ENSG00000167136ENDOG5597.546ENSSBOG00000019144ENDOG10097.546Saimiri_boliviensis_boliviensis
ENSG00000167136ENDOG9353.169ENSSHAG00000018851ENDOG10054.181Sarcophilus_harrisii
ENSG00000167136ENDOG9864.901ENSSFOG00015010139endog9664.570Scleropages_formosus
ENSG00000167136ENDOG8969.776ENSSMAG00000017279endog9466.894Scophthalmus_maximus
ENSG00000167136ENDOG7769.565ENSSLDG00000007492endog7364.400Seriola_lalandi_dorsalis
ENSG00000167136ENDOG9967.219ENSSPAG00000005798endog9965.101Stegastes_partitus
ENSG00000167136ENDOG10091.639ENSSSCG00000005661ENDOG10091.639Sus_scrofa
ENSG00000167136ENDOG7282.791ENSTGUG00000004197ENDOG10082.791Taeniopygia_guttata
ENSG00000167136ENDOG7565.625ENSTRUG00000018259endog6265.625Takifugu_rubripes
ENSG00000167136ENDOG9961.270ENSTNIG00000002481endog9762.046Tetraodon_nigroviridis
ENSG00000167136ENDOG7994.894ENSTBEG00000007286ENDOG9694.894Tupaia_belangeri
ENSG00000167136ENDOG9387.681ENSTTRG00000011615ENDOG9985.424Tursiops_truncatus
ENSG00000167136ENDOG8395.142ENSUAMG00000016280ENDOG10084.512Ursus_americanus
ENSG00000167136ENDOG7996.610ENSVVUG00000025998ENDOG8297.021Vulpes_vulpes
ENSG00000167136ENDOG9966.554ENSXETG00000025614endog9865.986Xenopus_tropicalis
ENSG00000167136ENDOG5974.286ENSXCOG00000012514endog5474.854Xiphophorus_couchianus
ENSG00000167136ENDOG6074.011ENSXMAG00000027949endog5775.439Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000014single-stranded DNA endodeoxyribonuclease activity21873635.IBAFunction
GO:0000737DNA catabolic process, endonucleolytic21873635.IBAProcess
GO:0001701in utero embryonic development-IEAProcess
GO:0003676nucleic acid binding-IEAFunction
GO:0004519endonuclease activity21873635.IBAFunction
GO:0004521endoribonuclease activity21873635.IBAFunction
GO:0004529exodeoxyribonuclease activity21873635.IBAFunction
GO:0005515protein binding25036637.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005739mitochondrion21873635.IBAComponent
GO:0005743mitochondrial inner membrane21873635.IBAComponent
GO:0005829cytosol-IEAComponent
GO:0006309apoptotic DNA fragmentation21873635.IBAProcess
GO:0006310DNA recombination18309324.TASProcess
GO:0007568aging-IEAProcess
GO:0009612response to mechanical stimulus-IEAProcess
GO:0032355response to estradiol-IEAProcess
GO:0034612response to tumor necrosis factor-IEAProcess
GO:0036475neuron death in response to oxidative stress-IEAProcess
GO:0043204perikaryon-IEAComponent
GO:0046677response to antibiotic-IEAProcess
GO:0046872metal ion binding-IEAFunction
GO:0071277cellular response to calcium ion-IEAProcess
GO:0071333cellular response to glucose stimulus-IEAProcess
GO:0071456cellular response to hypoxia-IEAProcess
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
GO:1901300positive regulation of hydrogen peroxide-mediated programmed cell death-IEAProcess
GO:1902512positive regulation of apoptotic DNA fragmentation-IEAProcess
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